Techniques for obtaining terbium-161 and related systems and methods

WO2025235824A8 Publication Date: 2026-01-29FUSION ENERGY SOLUTIONS INC
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Patent Information

Application Number
PCT/US2025/028509
Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
Priority Date
2024-05-09
Filing Date
2025-05-08
Publication Date
2026-01-29

AI Technical Summary

Technical Problem

Existing methods for producing radiotherapeutic isotopes like Terbium-161 and Actinium-225 face challenges in purifying precursor materials and separating daughter isotopes due to complex purification processes and resource-intensive enrichment requirements, which affect conversion efficiency and purity.

Method used

A method involving a liquid target system that passes through a fission reactor and an isotope capture device, where the liquid target solution is irradiated with a neutron flux, and the desired daughter isotopes are captured and purified using chromatography columns or zirconium oxide filters, minimizing the need for complex purification schemes and reducing time spent transferring materials.

Benefits of technology

This approach enhances the efficiency and purity of producing Terbium-161 and Actinium-225 by reducing the complexity of purification processes, allowing for higher conversion ratios and purer isotope collection, suitable for radiotherapeutic applications with improved therapeutic efficacy and safety.

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Abstract

The inventors have developed technology to improve the generation of daughter isotopes for clinical treatments. The technology includes systems and methods for using a liquid target to deliver parent isotopes to a reactor for neutron bombardment and subsequently separating desired daughter isotopes from the liquid target. According to an aspect of the technology described herein, a method of obtaining desired daughter isotopes comprises pumping a liquid target solution comprising a parent isotope through a fluid path that includes a first portion that passes through a fission reactor, a second portion that passes through a pump, and a third portion that passes through an isotope capture device.
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