Alternative substrate for automated clinical analyzer and methods of use
By incorporating multiple substrate materials and advanced pipetting systems, clinical analyzers achieve improved analyte detection flexibility and assay performance through optimized signal generation.
WO2026015434A1 Publication Date: 2026-01-15BECKMAN COULTER INC
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Patent Information
- Application Number
- PCT/US2025/036614
- Authority / Receiving Office
- WO · WO
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2025-01-16
- Filing Date
- 2025-07-07
- Publication Date
- 2026-01-15
AI Technical Summary
Technical Problem
Existing automated clinical analyzers lack flexibility in substrate materials for analyte detection, leading to limitations in sensitivity, detection time, and specificity in assays.
Method used
The implementation of multiple substrate materials in clinical analyzers, allowing selection between different substrates for enhanced analyte detection, including the use of sample racks and pipettes to load alternative substrates, and integration with climate-controlled storage and wash wheels for mixing and signal generation.
Benefits of technology
Enhances flexibility and performance in analyte detection by providing substrates with varied sensitivities and detection times, improving assay results through optimized signal generation and substrate selection.
✦ Generated by Eureka AI based on patent content.
Abstract
A method of performing an immunoassay with an automated clinical analyzer, includes, creating an assay mixture utilizing an analyte from a patient sample, a first reagent having a plurality of particles configured to specifically bind to the analyte and a second reagent having an enzyme. The method further includes incubating the assay mixture and then performing a wash cycle on the assay mixture to retain the plurality of particles while removing the remaining portion of the assay mixture not bound the plurality of particles. The method further includes selecting a first substrate material or a second substrate material. The method further includes obtaining the selected substrate material and adding the selected substrate material with the plurality of particles remaining from the wash cycle to create a signal generating mixture. The method further includes incubating the signal generating mixture and analyzing the signal generating mixture with a luminometer.
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