Novel application of azidothymidine in treating leukaemia

A technology for zidovudine and leukemia, which is applied in the directions of medical preparations containing active ingredients, antiviral agents, organic active ingredients, etc., can solve the problems that have never been seen before.

CN101559068AInactive Publication Date: 2009-10-21王意忠 +1
0 Cites 0 Cited by

Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
Publication Date
2009-10-21
Estimated Expiration
Not applicable · inactive patent

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention discloses novel application of azidothymidine in treating leukaemia. Pharmacodynamic experiments show that the azidothymidine has functions of inhibiting the growth of human leukaemia cells Jukat and murine leukemia cells L615, can inhibit the infiltrations of mouse peripheral blood, marrow and liver and spleen organizations, remarkably prolong the life cycle of a leukaemia mouse, and effectively reduce the leucovirus load of a Friend mouse spleen, and has significant effect on treating acute erythroleukemia induced by Friend mouse leucovirus.
Need to check novelty before this filing date? Find Prior Art

Description

field of invention

[0001] The invention relates to a new use of zidovudine, and the feature of the invention relates to a new use of zidovudine for treating leukemia. Background technique

[0002] Leukemia is a malignant disease of hematopoietic tissue, also known as "blood cancer". It is characterized by the unlimited proliferation of a large number of leukemia cells in the bone marrow and other hematopoietic tissues, and enters the peripheral blood, while the production of normal blood cells is significantly inhibited. Leukemia is a malignant tumor of the hematopoietic system and one of the most common malignant tumors in my country. According to the retrospective survey, the incidence rate of leukemia in various regions occupies the sixth place among all kinds of tumors, and the disease ranks first among malignant diseases among young people.

[0003] Azidothymidine (AZT) is a nucleoside reverse transcriptase inhibitor, which has been widely used in the world to treat A...

Examples

Embodiment 1

[0091] Embodiment 1: tablet

[0092] Azidothymidine is taken, added with conventional auxiliary materials, and prepared into tablets according to a conventional process for treating leukemia.

Embodiment 2

[0093] Embodiment 2: capsules

[0094] Azidothymidine is taken, added with conventional auxiliary materials, and prepared into capsules according to a conventional process, and used for inhibiting the growth of leukemia cells.

Embodiment 3

[0095] Embodiment 3: injection

[0096] Azidothymidine was taken, added with conventional excipients, and prepared into an injection according to a conventional process, which was used to inhibit the growth of human leukemia cell Jukat and mouse leukemia cell L615.