Preparing method for acanthopanax senticosus extract

Abstract

The invention relates to a preparing method for traditional Chinese medicine extract, in particular to a preparing method for acanthopanax senticosus extract. The preparing method comprises the steps that acanthopanax senticosus is subjected to countercurrent extraction through 40%-70% ethyl alcohol, line-sulfur treatment, alcohol precipitation, sterilization ultrafiltration belt type drying and other procedures, and the acanthopanax senticosus extract is prepared. By means of the method, impurities in the acanthopanax senticosus extract can be remarkably reduced, and the purity of effective ingredients in the acanthopanax senticosus extract and the safety and stability of the acanthopanax senticosus extract can be improved; meanwhile, the extraction cycle can be shortened, energy can be saved, high efficiency can be achieved, and the preparing method is especially suitable for industry production.

Description

technical field

[0001] The invention relates to a method for preparing a traditional Chinese medicine extract, in particular to a method for preparing an extract of Acanthopanax senticosus. Background technique

[0002] Acanthopanax senticosus (Acanthopanax senticosus) is a plant of Araliaceae. Its dried roots and stems have the medicinal effects of relaxing tendons and activating blood circulation, replenishing qi and invigorating the spleen, tonifying the kidney and calming the nerves. In the preparation of modern Chinese medicine, Acanthopanax is extracted and processed into injections, the main functions of which are to nourish the liver and kidney, benefit essence and strengthen bones, and is used to treat transient ischemic attacks caused by liver and kidney deficiency, cerebral arteriosclerosis, Cerebral thrombosis and cerebral embolism and other diseases; it is also used to treat coronary heart disease, angina pectoris combined with neurasthenia and menopausal syndro...

Examples

Embodiment 1

[0032] Embodiment 1: Preparation of Acanthopanax Acanthopanax Extract

[0033] 1) Extract 6kg of 40% ethanol with 3 volume times (18L) countercurrently to extract the medicinal materials of Acanthopanax senticosus. 1.20 (measured at 80°C);

[0034] 2) Dilute with 5 times the volume of purified water, stir evenly, filter, when the temperature of the filtrate is 30°C, adjust the pH value to 10.0 with 10% milk of lime, stir, then adjust the pH value to 5.0 with 10% sulfuric acid , continue to stir, stand still, filter the supernatant and recycle and concentrate to a relative density of 1.15 (measured at 80°C) to obtain a concentrated paste;

[0035] 3) Add ethanol with a concentration of 93% to make the ethanol concentration of the medicinal solution reach 75%, stir fully, let stand for 12 hours, filter the supernatant, recycle the ethanol from the filtrate until there is no alcohol smell, and concentrate to a relative density of 1.11 (measured at 80°C). );

[0036]4) Dilute w...

Embodiment 2

[0037] Embodiment 2: Preparation of Acanthopanax Acanthopanax Extract

[0038] 1) 8 times the volume (40L) of 70% ethanol countercurrently extracts 5kg of Acanthopanax senticosus medicinal materials, the countercurrent extraction flow rate is 35min / can, the extraction temperature is 80°C, and the extraction time is 0.5 hours, the combined extracts are concentrated to a relative density of 1.25 (measured at 80°C);

[0039] 2) Dilute with 10 times the volume of purified water, stir evenly, filter, and when the filtrate temperature is 50°C, adjust the pH value to 12.0 with 20% milk of lime, stir, and then adjust the pH value to 6.5 with 20% sulfuric acid , continue to stir, stand still, filter the supernatant and recycle and concentrate to a relative density of 1.25 (measured at 80°C) to obtain a concentrated paste;

[0040] 3) Add ethanol with a concentration of more than 98% to make the ethanol concentration of the medicinal solution reach 85%, fully stir, let stand for 24 hou...

Embodiment 3

[0042] Embodiment 3: Preparation of Acanthopanax Acanthopanax Extract

[0043] 1) 550% ethanol with 6 volume times (30L) countercurrently extracts 5kg of Acanthopanax acanthopanax medicinal material, the flow rate of countercurrent extraction is 30min / can, the extraction temperature is 50°C, and the extraction time is 1 hour, the extracts are combined and concentrated to a relative density of 1.25 (measured at 80°C);

[0044] 2) Dilute with 8 volume times of purified water, stir evenly, filter, and when the filtrate temperature is 40°C, adjust the pH value to 11 with 15% milk of lime, stir, and then adjust the pH value to 6 with 15% sulfuric acid , continue to stir, stand still, filter the supernatant and recycle and concentrate to a relative density of 1.25 (measured at 80°C) to obtain a concentrated paste;

[0045] 3) Add ethanol with a concentration of more than 95% to make the ethanol concentration of the medicinal solution reach 80%, fully stir, let stand for 16 hours, f...

technical field

[0001] The invention relates to a method for preparing a traditional Chinese medicine extract, in particular to a method for preparing an extract of Acanthopanax senticosus. Background technique

[0002] Acanthopanax senticosus (Acanthopanax senticosus) is a plant of Araliaceae. Its dried roots and stems have the medicinal effects of relaxing tendons and activating blood circulation, replenishing qi and invigorating the spleen, tonifying the kidney and calming the nerves. In the preparation of modern Chinese medicine, Acanthopanax is extracted and processed into injections, the main functions of which are to nourish the liver and kidney, benefit essence and strengthen bones, and is used to treat transient ischemic attacks caused by liver and kidney deficiency, cerebral arteriosclerosis, Cerebral thrombosis and cerebral embolism and other diseases; it is also used to treat coronary heart disease, angina pectoris combined with neurasthenia and menopausal syndro...

Examples

Embodiment 1

[0032] Embodiment 1: Preparation of Acanthopanax Acanthopanax Extract

[0033] 1) Extract 6kg of 40% ethanol with 3 volume times (18L) countercurrently to extract the medicinal materials of Acanthopanax senticosus. 1.20 (measured at 80°C);

[0034] 2) Dilute with 5 times the volume of purified water, stir evenly, filter, when the temperature of the filtrate is 30°C, adjust the pH value to 10.0 with 10% milk of lime, stir, then adjust the pH value to 5.0 with 10% sulfuric acid , continue to stir, stand still, filter the supernatant and recycle and concentrate to a relative density of 1.15 (measured at 80°C) to obtain a concentrated paste;

[0035] 3) Add ethanol with a concentration of 93% to make the ethanol concentration of the medicinal solution reach 75%, stir fully, let stand for 12 hours, filter the supernatant, recycle the ethanol from the filtrate until there is no alcohol smell, and concentrate to a relative density of 1.11 (measured at 80°C). );

[0036]4) Dilute w...

Embodiment 2

[0037] Embodiment 2: Preparation of Acanthopanax Acanthopanax Extract

[0038] 1) 8 times the volume (40L) of 70% ethanol countercurrently extracts 5kg of Acanthopanax senticosus medicinal materials, the countercurrent extraction flow rate is 35min / can, the extraction temperature is 80°C, and the extraction time is 0.5 hours, the combined extracts are concentrated to a relative density of 1.25 (measured at 80°C);

[0039] 2) Dilute with 10 times the volume of purified water, stir evenly, filter, and when the filtrate temperature is 50°C, adjust the pH value to 12.0 with 20% milk of lime, stir, and then adjust the pH value to 6.5 with 20% sulfuric acid , continue to stir, stand still, filter the supernatant and recycle and concentrate to a relative density of 1.25 (measured at 80°C) to obtain a concentrated paste;

[0040] 3) Add ethanol with a concentration of more than 98% to make the ethanol concentration of the medicinal solution reach 85%, fully stir, let stand for 24 hou...

Embodiment 3

[0042] Embodiment 3: Preparation of Acanthopanax Acanthopanax Extract

[0043] 1) 550% ethanol with 6 volume times (30L) countercurrently extracts 5kg of Acanthopanax acanthopanax medicinal material, the flow rate of countercurrent extraction is 30min / can, the extraction temperature is 50°C, and the extraction time is 1 hour, the extracts are combined and concentrated to a relative density of 1.25 (measured at 80°C);

[0044] 2) Dilute with 8 volume times of purified water, stir evenly, filter, and when the filtrate temperature is 40°C, adjust the pH value to 11 with 15% milk of lime, stir, and then adjust the pH value to 6 with 15% sulfuric acid , continue to stir, stand still, filter the supernatant and recycle and concentrate to a relative density of 1.25 (measured at 80°C) to obtain a concentrated paste;

[0045] 3) Add ethanol with a concentration of more than 95% to make the ethanol concentration of the medicinal solution reach 80%, fully stir, let stand for 16 hours, f...

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