Freeze dryer cycle cleaning equipment

Abstract

The invention discloses a freeze dryer circulation cleaning device, including a control system, a water storage tank, a circulation pipeline, a steam pipeline and a cooling water pipeline; a water injection pipe is provided on the top of the water storage tank, and a first solenoid valve is provided on the water injection pipe; the two ends of the circulation pipeline are respectively connected to the water storage tank, and a main solenoid valve, a circulation pump, a heat exchanger, a temperature sensor and a cleaning pipe are arranged at intervals on the circulation pipeline, and the cleaning pipes are all provided with a second solenoid valve and connected to the freeze dryer; the heat exchanger is respectively connected to the steam pipeline and the cooling water pipeline, the inlet of the steam pipeline is provided with a third solenoid valve, the inlet of the cooling water pipeline is provided with a fourth solenoid valve, and the control system is respectively connected to the main solenoid valve, the circulation pump, the temperature sensor, the first solenoid valve, the second solenoid valve, the third solenoid valve and the fourth solenoid valve. The present invention can not only use high temperature water to clean and disinfect the freeze dryer, but also disinfect the circulation pipeline for water delivery.

Description

Technical Field

[0001] The present invention relates to the technical field of freeze dryers, in particular to a freeze dryer circulation cleaning device. Background Art

[0002] As pharmaceutical equipment, freeze dryers have high cleanliness and biosafety requirements and must be thoroughly cleaned and disinfected before use. However, existing freeze dryer cleaning equipment only focuses on cleaning and disinfecting the freeze dryer itself, but not on disinfecting the water supply lines. This can lead to substandard cleaning and disinfection of the freeze dryer, and in severe cases, even affect subsequent pharmaceutical production.

[0003] Chinese patent (CN201728198U), a freeze dryer external circulation in-situ cleaning system, includes a cleaning water storage tank and a circulation pipeline, the cleaning water storage tank is provided with a water inlet, one end of the circulation pipeline is a freeze dryer water inlet interface, and the other end is a freeze dryer return water interface, the circulation pipeline has a water inlet connection and a drainage connection, the water inlet connection and the cleaning water storage tank are connected through a water inlet pipeline provided with a tank drain valve, the drainage connection is connected to a drainage pipeline provided with a tank main drain valve, and the circulation pipeline is provided with a circulation pump and a conductivity tester between the water inlet connection and the freeze dryer water inlet interface.

[0004] The above-mentioned existing technologies focus only on cleaning the freeze dryer, but not on disinfecting the water supply lines. This can lead to substandard cleaning and disinfection of the freeze dryer, and in serious cases, even affect subsequent drug production. Furthermore, the above-mentioned existing technologies can only clean a single freeze dryer, which is not conducive to large-scale production. Summary of the Invention

[0005] In response to the above problems, the present invention provides a freeze dryer circulation cleaning device, which can not only use high-temperature water to clean and disinfect the freeze dryer, but also disinfect the water supply circulation pipeline, thereby increasing the safe use of the freeze dryer.

[0006] The present invention adopts the following technical solutions to achieve the above purpose:

[0007] A freeze dryer circulation cleaning device is applied to the freeze dryer, comprising a control system, a water storage tank, a circulation pipeline, a steam pipeline and a cooling water pipeline; a water injection pipe is provided on the top of the water storage tank, and a first solenoid valve is provided on the water injection pipe; both ends of the circulation pipeline are respectively connected to the water storage tank, and a main solenoid valve, a circulation pump, a heat exchanger, a temperature sensor and a cleaning pipe are provided at intervals on the circulation pipeline, and the cleaning pipe is provided with a second solenoid valve and connected to the freeze dryer; the heat exchanger is respectively connected to the steam pipeline and the cooling water pipeline, a third solenoid valve is provided at the inlet of the steam pipeline, and a fourth solenoid valve is provided at the inlet of the cooling water pipeline, and the control system is respectively connected to the main solenoid valve, the circulation pump, the temperature sensor, the first solenoid valve, the second solenoid valve, the third solenoid valve and the fourth solenoid valve.

[0008] Preferably, a respirator is installed on the top of the water tank, one end of the respirator is connected to the atmosphere through an air intake pipe, and the other end is connected to the water tank through a ventilation pipe. A fifth solenoid valve is provided on the air intake pipe, and a sixth solenoid valve is provided on the ventilation pipe. The fifth solenoid valve and the sixth solenoid valve are respectively connected to the control system.

[0009] Preferably, the respirator is also provided with a drain pipe connected to the ventilation pipeline, and the end of the drain pipe away from the respirator is respectively connected to the first drain pipeline and the first bypass pipeline, the first drain pipeline is provided with a first drain valve and a seventh solenoid valve, the first bypass pipeline is provided with an eighth solenoid valve, and the control system is respectively connected to the first drain valve, the seventh solenoid valve and the eighth solenoid valve.

[0010] Preferably, the heat exchanger is provided with an upper interface and a lower interface at both ends, the upper interface is respectively connected to the inlet of the steam pipeline and the outlet of the cooling water pipeline, and the lower interface is respectively connected to the outlet of the steam pipeline and the inlet of the cooling water pipeline.

[0011] Preferably, the outlet of the steam pipeline is respectively connected to a second drain pipeline and a second bypass pipeline, the second drain pipeline is provided with a second drain valve and a ninth solenoid valve, the second bypass pipeline is provided with a tenth solenoid valve, and the control system is respectively connected to the second drain valve, the ninth solenoid valve and the tenth solenoid valve.

[0012] Preferably, the steam pressure of the steam pipeline is not less than 0.3 MPa, and the evaporation volume is not less than 0.445m 3 / h; the condensed water temperature entering the cooling water pipeline is 7-17°C, and the circulation volume is not less than 21.6m 3 / h.

[0013] Preferably, differential pressure level gauges are provided at both ends of the water storage tank, and the differential pressure level gauges are connected to the control system.

[0014] Preferably, a pressure sensor and a safety valve are spaced apart at the top of the water storage tank, and the pressure sensor and the safety valve are respectively connected to the control system.

[0015] Preferably, a pressure transmitter is provided on the circulation pipeline, and the pressure transmitter is connected to the control system.

[0016] Preferably, the circulation pipeline is located between the water storage tank and the cleaning pipe and is provided with a conductivity tester and a waste water pipe in sequence. The waste water pipe is provided with a waste water solenoid valve. The conductivity tester and the waste water solenoid valve are respectively connected to the control system, and the main solenoid valve is arranged between the waste water pipe and the cleaning pipe.

[0017] The beneficial effects of the present invention are:

[0018] 1. The freeze dryer circulation cleaning equipment provided by the present invention, when it is necessary to disinfect the circulation pipeline, the control system controls the main solenoid valve, the circulation pump and the third solenoid valve to open, so that the water in the water storage tank circulates in the circulation pipeline, and the steam is continuously used to heat the water in the circulation pipeline through the heat exchanger until the water temperature reaches 121°C, and then the 121°C hot water is continuously controlled to flow in the circulation pipeline for at least 30 minutes to disinfect the circulation pipeline. Disinfection uses internal circulation water to achieve the purpose of water saving. When it is necessary to disinfect the freeze dryer, the control system controls the second solenoid valve to open, so that 121°C hot water is injected into the freeze dryer through the cleaning pipe for disinfection. After the circulation pipeline and the freeze dryer are disinfected, the control system controls the third solenoid valve to close and the fourth solenoid valve to open, so that the condensed water is continuously used to cool the water in the circulation pipeline through the heat exchanger until the water temperature reaches below 80°C. When the freeze dryer needs to be cleaned, the control system controls the second solenoid valve to open, allowing hot water from the water storage tank to be injected into the freeze dryer through the cleaning pipe for cleaning. Wastewater from the freeze dryer disinfection and cleaning is discharged to the outside through the freeze dryer's waste outlet. This invention not only uses high-temperature water to clean and disinfect the freeze dryer, but also disinfects the water circulation pipeline, thereby increasing the safety of the freeze dryer.

[0019] 2. The freeze dryer circulation cleaning equipment provided by the present invention has a respirator on the top of the water storage tank, which keeps the water storage tank at normal pressure and regularly uses the superheated steam in the water storage tank to disinfect the respirator, further improving the safety of the entire cleaning equipment.

[0020] 3. The freeze dryer circulation cleaning equipment provided by the present invention can disinfect or clean multiple freeze dryers at the same time, thereby improving the utilization rate of the freeze dryer circulation cleaning equipment. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Figure 1A schematic structural diagram of a freeze dryer circulation cleaning device provided in an embodiment of the present invention;

[0022] Figure 2 A layout diagram of a heat exchanger in a freeze dryer circulation cleaning device provided in an embodiment of the present invention;

[0023] Figure 3 A schematic diagram of the connection between the water storage tank and the respirator in the freeze dryer circulation cleaning device provided by an embodiment of the present invention;

[0024] Figure 4 This is a connection diagram of the control system in the freeze dryer circulation cleaning equipment provided by an embodiment of the present invention.

[0025] In the figure, 1-freeze dryer, 2-control system, 3-water storage tank, 4-circulation pipeline, 5-steam pipeline, 6-cooling water pipeline, 7-water injection pipe, 8-first solenoid valve, 9-main solenoid valve, 10-circulation pump, 11-heat exchanger, 12-temperature sensor, 13-cleaning pipe, 14-second solenoid valve, 15-third solenoid valve, 16-fourth solenoid valve, 17-respirator, 18-intake pipe, 19-ventilation pipeline, 20-fifth solenoid valve, 21-sixth solenoid valve, 22-drain pipe, 23-first drain pipe, 24-first bypass pipe, 25-first drain valve, 26-seventh solenoid valve, 27-eighth solenoid valve, 28-upper interface, 29-lower interface, 30-second drain pipe, 31-second bypass pipe, 32-second drain valve, 33-ninth solenoid valve, 34-tenth solenoid valve, 35-differential pressure level gauge, 36-pressure sensor, 37-safety valve, 38-pressure transmitter, 39-conductivity tester, 40-waste water pipe, 41-waste water solenoid valve. DETAILED DESCRIPTION

[0026] The following is combined with Figures 1 to 4 The present invention is described in detail with specific embodiments.

[0027] Please also see Figure 1 and Figure 4An embodiment of the present invention provides a freeze dryer circulation cleaning device, which is applied to eight freeze dryers 1 and includes a control system 2, a water storage tank 3, a circulation pipeline 4, a steam pipeline 5 and a cooling water pipeline 6. Two water injection pipes 7 are provided at intervals on the top of the water storage tank 3, and each water injection pipe 7 is provided with a first solenoid valve 8 for controlling the water injection pipe 7 to inject water into the water storage tank 3. The two ends of the circulation pipeline 4 are respectively connected to the top and bottom of the water storage tank 3. A main solenoid valve 9, a circulation pump 10, a heat exchanger 11, five temperature sensors 12 and eight cleaning pipes 13 are provided at intervals on the circulation pipeline 4. Each cleaning pipe 13 is provided with a second solenoid valve 14 and is respectively connected to a freeze dryer 1. The heat exchanger 11 is respectively connected to the steam pipeline 5 and the cooling water pipeline 6. A third solenoid valve 15 is provided at the inlet of the steam pipeline 5, and a fourth solenoid valve 16 is provided at the inlet of the cooling water pipeline 6. The control system 2 is respectively connected to the main solenoid valve 9, the circulation pump 10, the temperature sensor 12, the first solenoid valve 8, the second solenoid valve 14, the third solenoid valve 15 and the fourth solenoid valve 16.

[0028] During use, when the circulation line 4 needs to be disinfected, the control system 2 controls the main solenoid valve 9, the circulation pump 10, and the third solenoid valve 15 to open, respectively, so that the water in the water storage tank 3 flows out from the bottom of the tank, is pumped into the circulation line 4 by the circulation pump 10, and flows back to the top of the tank; at the same time, the steam transported by the steam line 5 through the heat exchanger 11 continuously heats the water in the circulation line 4 until the temperature sensor 12 monitors the water temperature and reaches 121°C. Then, the 121°C hot water is controlled to flow in the circulation line 4 for at least 30 minutes to disinfect the circulation line 4. When the freeze dryer 1 needs to be disinfected, the control system 2 controls the second solenoid valve 14 to open, so that the 121°C hot water is injected into the freeze dryer 1 through the cleaning pipe 13 for disinfection. After the disinfection of the circulation pipeline 4 and the freeze dryer 1 is completed, the control system 2 controls the third solenoid valve 15 to close and the fourth solenoid valve 16 to open, so that the condensed water transported by the cooling water pipeline 6 continuously cools the water in the circulation pipeline 4 through the heat exchanger 11 until the water temperature detected by the temperature sensor 12 reaches below 80°C, at which point the control system 2 closes the fourth solenoid valve 16. When the freeze dryer 1 needs to be cleaned, the control system 2 controls the second solenoid valve 14 to open, so that the hot water in the water storage tank 3 is injected into the freeze dryer 1 through the cleaning pipe 13 to clean the freeze dryer 1. The waste water after the disinfection and cleaning of the freeze dryer 1 is discharged to the outside through the waste outlet of the freeze dryer 1.

[0029] Further, please also see Figure 3 and Figure 4In this embodiment, a respirator 17 is installed on the top of the water tank 3 to maintain a constant pressure inside the water tank 3. One end of the respirator 17 is connected to the atmosphere via an air intake pipe 18, and the other end is connected to the water tank 3 via a ventilation line 19. A fifth solenoid valve 20 is provided on the air intake pipe 18, and a sixth solenoid valve 21 is provided on the ventilation line 19. The fifth and sixth solenoid valves 20 and 21 are respectively connected to the control system 2. The control system 2 controls the opening of the fifth and sixth solenoid valves 20 and 21, allowing air to enter the water tank 3 from the air intake pipe 18, the respirator 17, and the ventilation line 19 in sequence to maintain a constant pressure inside the water tank 3. The fifth and sixth solenoid valves 20 and 21 are normally open.

[0030] The respirator 17 is also equipped with a drain pipe 22 connected to the ventilation line 19. The end of the drain pipe 22, away from the respirator 17, is connected to a first drain pipe 23 and a first bypass pipe 24, respectively. The first drain pipe 23 is equipped with a first drain valve 25 and a seventh solenoid valve 26, while the first bypass pipe 24 is equipped with an eighth solenoid valve 27. The control system 2 is connected to the first drain valve 25, the seventh solenoid valve 26, and the eighth solenoid valve 27. When disinfecting the respirator 17, the control system 2 closes the fifth solenoid valve 20 and opens the sixth solenoid valve 21, the first drain valve 25, and the seventh solenoid valve 26. Superheated steam from the 121°C water in the water tank 3 enters the respirator 17 through the ventilation line 19 to disinfect it. The condensed water is then discharged from the drain pipe 22 and the first drain pipe 23, respectively. When the first drain line 23 is unobstructed, the control system 2 closes the first bypass line 24 via the eighth solenoid valve 27, allowing steam condensate to be discharged from the first drain line 23. If the first drain line 23 fails, the control system 2 opens the first bypass line 24 via the eighth solenoid valve 27, allowing steam condensate to be discharged from the first bypass line 24. Because the first drain valve 25 is prone to failure, the first bypass line 24 is used as a backup line to increase the safety and continuous use of the entire pipeline.

[0031] Further, please also see Figure 2 and Figure 4In this embodiment, an upper port 28 and a lower port 29 are provided at both ends of the heat exchanger 11. The upper port 28 is connected to the inlet of the steam pipeline 5 and the outlet of the cooling water pipeline 6, respectively, and the lower port 29 is connected to the outlet of the steam pipeline 5 and the inlet of the cooling water pipeline 6. The hot steam in the steam pipeline 5 enters the heat exchanger 11 through the upper port 28 and then flows out of the lower port 29 of the heat exchanger 11 to heat the water in the circulation pipeline 4 located within the heat exchanger 11. The condensed water in the cooling water pipeline 6 enters the heat exchanger 11 through the lower port 29 and then flows out of the upper port 28 of the heat exchanger 11 to cool the water in the circulation pipeline 4 located within the heat exchanger 11. The outlet of the steam pipeline 5 is used to discharge the steam condensate. The outlet of the steam pipeline 5 is connected to the second drain pipeline 30 and the second bypass pipeline 31 respectively. The second drain pipeline 30 is provided with a second drain valve 32 and a ninth solenoid valve 33, and the second bypass pipeline 31 is provided with a tenth solenoid valve 34. The control system 2 is connected to the second drain valve 32, the ninth solenoid valve 33 and the tenth solenoid valve 34 respectively. When the second drain pipeline 30 is in a clear state, the control system 2 closes the second bypass pipeline 31 through the tenth solenoid valve 34 to discharge steam condensate from the second drain pipeline 30. When the second drain pipeline 30 fails, the control system 2 opens the second bypass pipeline 31 through the tenth solenoid valve 34 to discharge steam condensate from the second bypass pipeline 31. Because the second drain valve 32 is prone to failure, the second bypass pipeline 31 is set as a backup pipeline to increase the safety and continuous use of the entire pipeline. The steam pressure entering the steam pipeline 5 is not less than 0.3MPa, and the evaporation capacity is not less than 0.445m 3 / h; the temperature of the condensed water entering the cooling water pipe 6 is 7-17℃, and the circulation volume is not less than 21.6m 3 / h.

[0032] Further, please also see Figure 1 and Figure 4 In this embodiment, a differential pressure level gauge 35 is provided at both ends of the water tank 3, and the differential pressure level gauge 35 is connected to the control system 2. The differential pressure level gauge 35 is used to detect the liquid level in the water tank 3. When the differential pressure level gauge 35 detects that the liquid level in the water tank 3 is lower than the set value, the differential pressure level gauge 35 sends a signal to the control system 2. When the control system 2 receives the signal from the differential pressure level gauge 35, it controls the first solenoid valve 8 to open, so that the water injection pipe 7 can inject water into the water tank 3. When the differential pressure level gauge 35 detects that the liquid level in the water tank 3 reaches the set value, the differential pressure level gauge 35 sends a signal to the control system 2. When the control system 2 receives the signal from the differential pressure level gauge 35, it controls the first solenoid valve 8 to close. Such a design can ensure that the liquid level in the water tank 3 is at a stable value to prevent water shortage or overflow.

[0033] Furthermore, in this embodiment, a pressure sensor 36 and a safety valve 37 are spaced apart at the top of the water tank 3. The pressure sensor 36 and the safety valve 37 are respectively connected to the control system 2. When the pressure sensor 36 detects that the pressure in the water tank 3 exceeds a set value, the pressure sensor 36 sends a signal to the control system 2. Upon receiving the signal from the pressure sensor 36, the control system 2 controls the safety valve 37 to open, thereby releasing the air pressure in the water tank 3 to the outside. This prevents the water tank 3 from bursting due to excessive internal pressure, further effectively ensuring the safe use of the water tank 3.

[0034] Furthermore, in this embodiment, a pressure transmitter 38 is provided on the circulation pipeline 4, and the pressure transmitter 38 is connected to the control system 2. The control system 2 monitors the pressure changes of the water in the circulation pipeline 4 based on the pressure transmitter 38, thereby converting the changes in the water flow rate. Because the flow meter is prone to deviations in measurement results due to changes in water temperature, the present invention uses a pressure transmitter 38 instead of a flow meter to obtain more accurate measurement data. The circulation pipeline 4 is located between the water storage tank 3 and the cleaning pipe 13 and is provided with a conductivity tester 39 and a waste water pipe 40 in sequence. The waste water pipe 40 is provided with a waste water solenoid valve 41. The conductivity tester 39 and the waste water solenoid valve 41 are respectively connected to the control system 2. The main solenoid valve 9 is arranged between the waste water pipe 40 and the cleaning pipe 13. When there is a requirement for injection water for the freeze dryer 1, the conductivity tester 39 is used to monitor the conductivity of the water in the circulation pipeline 4 and transmit the data to the control system 2. When the control system 2 finds that the data is not within the set value range, the control system 2 controls the main solenoid valve 9 to close, and then controls the waste water solenoid valve 41 to open, so that the unqualified water in the water storage tank 3 is discharged from the waste water pipe 40.

[0035] It is understandable that the number of freeze dryers 1 is not limited to eight, and in other embodiments, the number of freeze dryers 1 may be more or less than eight.

[0036] It can be understood that the number of water injection pipes 7 is not limited to two, and in other embodiments, there may be more or less than two.

[0037] It is understood that the number of cleaning pipes 13 is not limited to eight, and in other embodiments, it can be more or less than eight. It is understood that the number of temperature sensors 12 is not limited to five, and in other embodiments, it can be more or less than five.

Claims

1. A freeze dryer circulation cleaning device, applied to a freeze dryer, characterized in that: The invention comprises a control system, a water storage tank, a circulation pipeline, a steam pipeline and a cooling water pipeline; a water injection pipe is arranged on the top of the water storage tank, and a first solenoid valve is arranged on the water injection pipe; both ends of the circulation pipeline are respectively connected to the water storage tank, and a main solenoid valve, a circulation pump, a heat exchanger, a temperature sensor and a cleaning pipe are arranged on the circulation pipeline at intervals, and the cleaning pipe is provided with a second solenoid valve and connected to the freeze dryer; the heat exchanger is respectively connected to the steam pipeline and the cooling water pipeline, a third solenoid valve is arranged at the inlet of the steam pipeline, and a fourth solenoid valve is arranged at the inlet of the cooling water pipeline, and the control system is respectively connected to the main solenoid valve, the circulation pump, the temperature sensor, the first solenoid valve, the second solenoid valve, the third solenoid valve and the fourth solenoid valve; a respirator is installed on the top of the water storage tank, and one end of the respirator is connected to a large The air inlet pipe is provided with a fifth solenoid valve, the ventilation pipe is provided with a sixth solenoid valve, and the fifth solenoid valve and the sixth solenoid valve are respectively connected to the control system; the respirator is also provided with a drain pipe connected to the ventilation pipe, and the end of the drain pipe away from the respirator is respectively connected to the first drain pipe and the first bypass pipe, the first drain pipe is provided with a first drain valve and a seventh solenoid valve, the first bypass pipe is provided with an eighth solenoid valve, and the control system is respectively connected to the first drain valve, the seventh solenoid valve and the eighth solenoid valve; the two ends of the heat exchanger are respectively provided with an upper interface and a lower interface, the upper interface is respectively connected to the inlet of the steam pipeline and the outlet of the cooling water pipeline, and the lower interface is respectively connected to the outlet of the steam pipeline and the inlet of the cooling water pipeline.

2. The freeze dryer circulation cleaning equipment according to claim 1, characterized in that: The outlet of the steam pipeline is respectively connected to a second drain pipeline and a second bypass pipeline, the second drain pipeline is provided with a second drain valve and a ninth solenoid valve, the second bypass pipeline is provided with a tenth solenoid valve, and the control system is respectively connected to the second drain valve, the ninth solenoid valve and the tenth solenoid valve.

3. The freeze dryer circulation cleaning equipment according to claim 1, characterized in that: The steam pressure introduced into the steam pipeline is not less than 0.3MPa, and the evaporation capacity is not less than 0.445m3 / h; the condensed water temperature introduced into the cooling water pipeline is 7-17°C, and the circulation capacity is not less than 21.6m3 / h.

4. The freeze dryer circulation cleaning device according to claim 1, characterized in that: Both ends of the water storage tank are provided with differential pressure level gauges, and the differential pressure level gauges are connected to the control system.

5. The freeze dryer circulation cleaning equipment according to claim 1, characterized in that: A pressure sensor and a safety valve are provided at intervals on the top of the water storage tank, and the pressure sensor and the safety valve are respectively connected to the control system.

6. The freeze dryer circulation cleaning device according to claim 1, characterized in that: The circulation pipeline is provided with a pressure transmitter, and the pressure transmitter is connected to the control system.

7. The freeze dryer circulation cleaning device according to claim 1, characterized in that: The circulation pipeline is located between the water storage tank and the cleaning pipe and is provided with a conductivity tester and a waste water pipe in sequence. The waste water pipe is provided with a waste water solenoid valve. The conductivity tester and the waste water solenoid valve are respectively connected to the control system. The main solenoid valve is arranged between the waste water pipe and the cleaning pipe.

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