Poria-cocos-extract preparing method and application of poria cocos extract in aspect of preparing medicines/health care products for treating/controlling high-uric-acid related diseases

Abstract

The invention relates to an extract preparing method and application of an extract in the aspect of preparing medicines / health care products for treating / controlling high-uric-acid related diseases, in particular to a poria-cocos-extract preparing method and application of a poria cocos extract in the aspect of preparing medicines / health care products for treating / controlling high-uric-acid related diseases. The poria-cocos-extract preparing method and application have the advantages that the preparing technology of the poria cocos extract is simple, and the cost is low; ethyl alcohol or wateror a mixed solvent of ethyl alcohol and water serves as a solvent for extracting poria cocos, the pollution or residual problem of an organic solvent is solved, and safe and environment-friendly effects are achieved; the poria cocos extract has a remarkable uric-acid reducing effect, is small in side effect, can be used for preparing a medicine for reliving a gout disease, and provides a new direction for improving a phenomenon of a large side effect of a present gout disease medicine.

Description

technical field

[0001] The present invention relates to a preparation method of an extract and its application in the preparation of medicines / health products for the treatment / prevention of high uric acid-related diseases, in particular to a preparation method of Poria cocos extract and its use in the preparation of medicines for the treatment / prevention of high uric acid-related diseases. Applications in medicine / health care products. Background technique

[0002] Uric acid is the final product of the breakdown of purine metabolism. Excessive production of uric acid due to some reasons or decreased excretion of uric acid by the kidneys can lead to increased blood uric acid content. Hyperuricemia-related diseases are a type of diseases in which the production of uric acid in the body increases and the excretion of uric acid in the kidneys decreases, making the concentration of uric acid in the body higher than the dissolving capacity of the blood (>360 μmol / L). With th...

Examples

preparation example Construction

[0056] A preparation method of a preferred Poria cocos extract, comprising:

[0057] (1) the dried Poria cocos entity is pulverized;

[0058] (2) Extract with 2L / (100g Poria cocos) ethanol in a water bath at 65°C for 3 hours, then filter under reduced pressure to separate the filter residue and filtrate, repeat three times;

[0059] (3) The filtrates obtained in step (2) were combined and concentrated to 25-35mL / (100g Poria cocos) after vacuum distillation, and freeze-dried to obtain the alcoholic extract of Poria cocos;

[0060] (4) Extracting the alcohol-extracted Poria cocos residue with water as a solvent in a water bath at 85°C for 3 hours, and then filtering under reduced pressure to separate the filter residue and filtrate, repeating three times;

[0061] (5) The filtrates obtained in step (4) were combined and then concentrated by distillation under reduced pressure to 25-35 mL / (100 g Poria cocos), and freeze-dried to obtain the water extract of Poria cocos.

[0062] F...

Embodiment 1

[0086] The preparation of embodiment 1 Poria cocos ethanol extract

[0087] Take 100 g of Poria cocos fruiting body, pulverize it with a pulverizer, put it into an Erlenmeyer flask, and add 2L of ethanol, extract the mixture in a water bath at 65°C for 3 hours, and then filter it with a 400-mesh filter. The extraction experiment was repeated three times, and the resulting filtrates were combined, concentrated by distillation under reduced pressure, and freeze-dried to obtain 1.22 g of Poria ethanol extract (PCE), with a yield of 1.22%.

Embodiment 2

[0088] The preparation of embodiment 2 Poria cocos water extract

[0089] In a water bath at 85°C, use 2L of water as a solvent to extract the Poria cocos residue after alcohol extraction for 3 hours, and then filter under reduced pressure to separate the filter residue and filtrate. The extraction experiment was repeated three times. Compound (PCW) 1.29 g, yield 1.29%.

technical field

[0001] The present invention relates to a preparation method of an extract and its application in the preparation of medicines / health products for the treatment / prevention of high uric acid-related diseases, in particular to a preparation method of Poria cocos extract and its use in the preparation of medicines for the treatment / prevention of high uric acid-related diseases. Applications in medicine / health care products. Background technique

[0002] Uric acid is the final product of the breakdown of purine metabolism. Excessive production of uric acid due to some reasons or decreased excretion of uric acid by the kidneys can lead to increased blood uric acid content. Hyperuricemia-related diseases are a type of diseases in which the production of uric acid in the body increases and the excretion of uric acid in the kidneys decreases, making the concentration of uric acid in the body higher than the dissolving capacity of the blood (>360 μmol / L). With th...

Examples

preparation example Construction

[0056] A preparation method of a preferred Poria cocos extract, comprising:

[0057] (1) the dried Poria cocos entity is pulverized;

[0058] (2) Extract with 2L / (100g Poria cocos) ethanol in a water bath at 65°C for 3 hours, then filter under reduced pressure to separate the filter residue and filtrate, repeat three times;

[0059] (3) The filtrates obtained in step (2) were combined and concentrated to 25-35mL / (100g Poria cocos) after vacuum distillation, and freeze-dried to obtain the alcoholic extract of Poria cocos;

[0060] (4) Extracting the alcohol-extracted Poria cocos residue with water as a solvent in a water bath at 85°C for 3 hours, and then filtering under reduced pressure to separate the filter residue and filtrate, repeating three times;

[0061] (5) The filtrates obtained in step (4) were combined and then concentrated by distillation under reduced pressure to 25-35 mL / (100 g Poria cocos), and freeze-dried to obtain the water extract of Poria cocos.

[0062] F...

Embodiment 1

[0086] The preparation of embodiment 1 Poria cocos ethanol extract

[0087] Take 100 g of Poria cocos fruiting body, pulverize it with a pulverizer, put it into an Erlenmeyer flask, and add 2L of ethanol, extract the mixture in a water bath at 65°C for 3 hours, and then filter it with a 400-mesh filter. The extraction experiment was repeated three times, and the resulting filtrates were combined, concentrated by distillation under reduced pressure, and freeze-dried to obtain 1.22 g of Poria ethanol extract (PCE), with a yield of 1.22%.

Embodiment 2

[0088] The preparation of embodiment 2 Poria cocos water extract

[0089] In a water bath at 85°C, use 2L of water as a solvent to extract the Poria cocos residue after alcohol extraction for 3 hours, and then filter under reduced pressure to separate the filter residue and filtrate. The extraction experiment was repeated three times. Compound (PCW) 1.29 g, yield 1.29%.

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