Tissue clamping device

Abstract

The present application discloses a tissue clamping device, which comprises a clamp body, a first connecting member, a second connecting member and a clamping piece; the clamp body comprises a supporting part, a first inner clamp arm, a first outer clamp arm, a second inner clamp arm and a second outer clamp arm, one side of the supporting part is bendably connected to the first inner clamp arm and the first outer clamp arm in sequence, and the other side is bendably connected to the second inner clamp arm and the second outer clamp arm in sequence, and the clamp body is an integrally formed structure; the clamp body is connected between the first connecting member and the second connecting member, and the relative movement of the first connecting member and the second connecting member can drive the first inner clamp arm and the second inner clamp arm to open or close relative to each other; the clamping piece comprises a first clamping piece arranged on the first inner clamp arm and a second clamping piece arranged on the second inner clamp arm, and the first clamping piece and the second clamping piece can be opened and closed relative to the first inner clamp arm and the second inner clamp arm respectively, so that the tissue can be clamped between the first clamping piece and the first inner clamp arm and between the second clamping piece and the second inner clamp arm.

Description

Technical Field

[0001] The present application relates to the field of medical supplies, and in particular to a tissue clamping device. Background Art

[0002] In surgical repair of body tissues, it is usually necessary to clamp and fix the tissues by means of a tissue clamping device. Taking the treatment of mitral regurgitation, a relatively common heart disease, as an example, the mitral valve is located between the left atrium and the left ventricle. When the left ventricle contracts, the mitral valve acts as a check valve to tightly close the atrioventricular orifice to prevent blood from flowing back from the left ventricle to the left atrium. However, when the mitral valve is diseased, it may be difficult for the mitral valve to close completely when the left ventricle contracts, causing the left atrium to receive a large amount of refluxed blood, which may cause a sharp increase in left atrial and pulmonary venous pressure, increase the left ventricular diastolic volume load, and further lead to a series of pathological changes such as left ventricular enlargement and pulmonary hypertension, ultimately leading to clinical manifestations such as heart failure and arrhythmia, which can be life-threatening in severe cases. In the operation to treat mitral regurgitation, a tissue clamping device can be used to clamp the opposite side of the mitral valve, so that the hole between the mitral valves changes from a large hole to two small holes, reducing the regurgitation area, thereby effectively preventing the occurrence of mitral regurgitation. Similarly, the tissue clamping device can also be applied to the tricuspid valve of the heart to reduce the regurgitation area by clamping the valve leaflets on both sides. Summary of the invention

[0003] One of the embodiments of the present application provides a tissue clamping device, which includes a clamp body, a first connecting member, a second connecting member and a clamping piece; the clamp body includes a supporting portion, a first inner clamp arm, a first outer clamp arm, a second inner clamp arm and a second outer clamp arm, one side of the supporting portion is bendably connected to the first inner clamp arm and the first outer clamp arm in sequence, and the other side of the supporting portion is bendably connected to the second inner clamp arm and the second outer clamp arm in sequence, and the clamp body is an integrally formed structure; the clamp body is connected between the first connecting member and the second connecting member, and the relative movement of the first connecting member and the second connecting member can drive the first inner clamp arm and the second inner clamp arm to open or close relative to each other; the clamping piece includes a first clamping piece arranged on the first inner clamp arm and a second clamping piece arranged on the second inner clamp arm, the first clamping piece and the second clamping piece can be opened and closed relative to the first inner clamp arm and the second inner clamp arm respectively, and enable the tissue to be clamped between the first clamping piece and the first inner clamp arm and between the second clamping piece and the second inner clamp arm.

[0004] In some embodiments, one end of the support portion is connected to the first connecting member, and one end of the first outer clamping arm and one end of the second outer clamping arm are respectively connected to the second connecting member.

[0005] In some embodiments, one side of the support portion is connected to the first inner clamp arm through a first bending structure; the other side of the support portion is connected to the second inner clamp arm through a first bending structure; the first bending structure is an S-rod bending structure or a waist-slimming bending structure; the first inner clamp arm is connected to the first outer clamp arm through a second bending structure; the second inner clamp arm is connected to the second outer clamp arm through a second bending structure; the second bending structure is an S-rod bending structure or a waist-slimming bending structure.

[0006] In some embodiments, the S-rod bending structure includes at least three straight rods and two bent rods, the three straight rods are parallel to each other and the three straight rods are connected end to end through the two bent rods.

[0007] In some embodiments, the support portion is a grid structure; the grid structure includes a diamond grid, a circular grid, a rectangular grid, a square grid, a triangular grid or a regular polygonal grid.

[0008] In some embodiments, the clip body is an integrally formed structure made by cutting and heat treating a shape memory alloy tube.

[0009] In some embodiments, the clip is a barbed clip, which includes a fixing portion, a clamping portion and barbs; one end of the fixing portion is connected to one end of the clamping portion through a bending portion; and the other end of the clamping portion is provided with the barb.

[0010] In some embodiments, the fixing portion, the clamping portion and the barb are an integrally formed structure.

[0011] In some embodiments, the barbs include a plurality of barbed strips; wherein at least one barbed strip is connected to the other end of the clamping portion via an S-rod bending structure, and / or at least one barbed strip is provided with a through hole.

[0012] In some embodiments, the barb is detachably connected to the other end of the clamping portion; the other end of the clamping portion includes a slot, and the barb includes a snap ring, which can be snap-fitted with the slot.

[0013] In some embodiments, the fixing portion and the clamping portion are an integrally formed structure made of shape memory alloy through cutting and heat treatment; after heat treatment, the fixing portion and the clamping portion are at a certain angle, and the bending portion has a prefabricated resilience.

[0014] In some embodiments, the first inner clamp arm and the second inner clamp arm are provided with through holes matching with the barbs.

[0015] In some embodiments, the first inner clamp arm and the second inner clamp arm are provided with a clamping hole that cooperates with the fixing portion of the barbed clamp, and the fixing portion can be embedded in the clamping hole; the first inner clamp arm and the second inner clamp arm are also provided with a fixing groove, and the tissue clamping device also includes a fixing ring, which can be clamped with the fixing groove to limit the fixing portion from being separated from the clamping hole.

[0016] In some embodiments, the fixing portion and the clamping portion of the barbed clip are integrally formed with the clip body.

[0017] In some embodiments, the tissue clamping device also includes a locking mechanism, which includes a locking tube and a locking piece; one end of the locking tube is fixedly connected to the second connecting piece, and a locking wing is provided on the outer wall of the locking tube; the locking piece is fixedly connected to the supporting portion; the locking wing can limit the relative opening of the first inner clamp arm and the second inner clamp arm by limiting the movement of the locking piece.

[0018] In some embodiments, the locking mechanism also includes a sleeve, which can be sleeved on the outside of the locking tube and retract the locking wing; the tissue clamping device also includes a brake rod, which is fixedly connected to the sleeve and can be detachably connected to the locking tube; when the brake rod is connected to the locking tube, the sleeve can retract the locking wing; when the brake rod is disengaged from the locking tube, the sleeve releases the effect on the locking wing, and the locking wing opens.

[0019] In some embodiments, the locking fins include at least two fins, and the at least two locking fins are arranged on the outer wall of the locking tube at different distances from the second connecting member; the at least two locking fins can limit the opening of the clamp body when the first inner clamp arm and the second inner clamp arm are relatively opened to different angles.

[0020] In some embodiments, the tissue clamping device also includes an elastic support, which includes a first support rod, a second support rod, a first mounting portion and a second mounting portion; one end of the first support rod and the second support rod are connected to the first mounting portion; the other end of the first support rod and the second support rod are connected to the second mounting portion; the first support rod, the second support rod, the first mounting portion and the second mounting portion are an integrally formed structure; the first mounting portion and the second mounting portion of the elastic support are fixedly connected to the second connecting member; the first support rod of the elastic support is abutted at the connection between the first inner clamp arm and the first outer clamp arm; the second support rod of the elastic support is abutted at the connection between the second inner clamp arm and the second outer clamp arm.

[0021] In some embodiments, one end of the first support rod and the second support rod is connected to the first mounting portion via an S-rod bending structure; the other end of the first support rod and the second support rod is connected to the second mounting portion via an S-rod bending structure.

[0022] In some embodiments, one end of the first support rod and the second support rod is connected to the first mounting portion via a first connecting portion; the other end of the first support rod and the second support rod is connected to the second mounting portion via a second connecting portion; and through holes are provided on the first connecting portion and the second connecting portion.

[0023] One of the embodiments of the present application provides a clamp body of a tissue clamping device, wherein the clamp body includes a supporting portion, a first inner clamp arm, a first outer clamp arm, a second inner clamp arm, and a second outer clamp arm, wherein one side of the supporting portion is bendably connected to the first inner clamp arm and the first outer clamp arm in sequence, and the other side of the supporting portion is bendably connected to the second inner clamp arm and the second outer clamp arm in sequence, and the clamp body is an integrally formed structure.

[0024] In some embodiments, one side of the support portion is connected to the first inner clamp arm through a first bending structure; the other side of the support portion is connected to the second inner clamp arm through a first bending structure; the first inner clamp arm is connected to the first outer clamp arm through a second bending structure; and the second inner clamp arm is connected to the second outer clamp arm through a second bending structure.

[0025] In some embodiments, the first bending structure is an S-rod bending structure or a waist-slimming bending structure; the second bending structure is an S-rod bending structure or a waist-slimming bending structure.

[0026] In some embodiments, the S-rod bending structure includes at least three straight rods and two bent rods, the three straight rods are parallel to each other and the three straight rods are connected end to end through the two bent rods.

[0027] In some embodiments, the support portion is a grid structure; the grid structure includes a diamond grid, a circular grid, a rectangular grid, a square grid, a triangular grid or a regular polygonal grid.

[0028] In some embodiments, the cross-sectional shape of the support portion is circular or elliptical; the cross-sectional area of ​​the middle portion of the support portion is larger than the cross-sectional areas of both ends thereof.

[0029] In some embodiments, the first inner clamp arm and the second inner clamp arm include barbed clips that are cut and formed integrally.

[0030] In some embodiments, the first outer clamp arm and the second outer clamp arm include a plurality of through holes, and the plurality of through holes can assist the first outer clamp arm and the second outer clamp arm in deforming during a heat treatment process.

[0031] In some embodiments, the clip body is an integrally formed structure made by cutting and heat treating a shape memory alloy tube.

[0032] One of the embodiments of the present application provides a tissue clamping device, which includes the clamp body described in any embodiment of the present application.

[0033] One of the embodiments of the present application provides a barbed clip, which includes a fixing portion, a clamping portion and a barb; one end of the fixing portion is connected to one end of the clamping portion via a bending portion; and the other end of the clamping portion is provided with the barb.

[0034] In some embodiments, the bending portion is an S-rod bending structure.

[0035] In some embodiments, the S-rod bending structure includes at least three straight rods and two bent rods, the three straight rods are parallel to each other and the three straight rods are connected end to end through the two bent rods.

[0036] In some embodiments, the fixing portion, the clamping portion and the barb are an integrally formed structure.

[0037] In some embodiments, the barb includes a plurality of barbed strips, and at least one barbed strip is connected to the other end of the clamping portion via an S-rod bending structure.

[0038] In some embodiments, the barbs include a plurality of barbs, and at least one barb is provided with a through hole.

[0039] In some embodiments, the barb is detachably connected to the other end of the clamping portion.

[0040] In some embodiments, the other end of the clamping portion includes a slot, and the barb includes a snap ring that can be snap-fitted with the slot.

[0041] In some embodiments, the fixing portion and the clamping portion are an integrally formed structure made of shape memory alloy through cutting and heat treatment.

[0042] In some embodiments, the fixing portion and the clamping portion are at a certain angle after heat treatment, and the bending portion has a prefabricated resilience.

[0043] One of the embodiments of the present application provides a tissue clamping device, which includes the barbed clip described in any embodiment of the present application.

[0044] In some embodiments, the tissue clamping device includes an inner clamp arm, and the barbed clamp is disposed on the inner clamp arm.

[0045] In some embodiments, the inner clamp arm is provided with a through hole that matches the barb.

[0046] In some embodiments, the inner clamp arm is provided with a clamping hole that cooperates with the fixing portion of the barbed clip, and the fixing portion can be embedded in the clamping hole; the inner clamp arm is also provided with a fixing groove, and the tissue clamping device also includes a fixing ring, which can be clamped with the fixing groove to limit the fixing portion from detaching from the clamping hole.

[0047] In some embodiments, the fixing portion and the clamping portion of the barbed clip are integrally formed with the inner clamp arm.

[0048] One of the embodiments of the present application provides a tissue clamping device with a locking mechanism, comprising a clamp body, a first connecting member, a second connecting member and a locking mechanism; the clamp body is connected between the first connecting member and the second connecting member, and the relative movement of the first connecting member and the second connecting member can drive the clamp body to open or close; the locking mechanism comprises a locking tube, one end of which is fixedly connected to the second connecting member, and the outer wall of the locking tube is provided with a locking wing, and the locking wing can limit the opening of the clamp body.

[0049] In some embodiments, the locking mechanism further includes a locking member, which is fixedly connected to the clip body; the locking wing restricts the opening of the clip body by restricting the movement of the locking member.

[0050] In some embodiments, the clip body includes a supporting portion, and the locking member is fixedly connected to the supporting portion.

[0051] In some embodiments, the locking mechanism further includes a sleeve, which can be sleeved outside the locking tube and retract the locking wing.

[0052] In some embodiments, the tissue clamping device also includes a brake rod, which is fixedly connected to the sleeve and can be detachably connected to the locking tube; when the brake rod is connected to the locking tube, the sleeve can retract the locking wing; when the brake rod is disengaged from the locking tube, the sleeve releases the effect on the locking wing, and the locking wing opens.

[0053] In some embodiments, the brake rod is connected to the locking tube by threads.

[0054] In some embodiments, the locking fins include at least two fins, and the at least two locking fins are symmetrically arranged on the outer wall of the locking tube at the same distance from the second connecting member.

[0055] In some embodiments, the locking fins include at least two pieces, and the at least two locking fins are arranged on the outer wall of the locking tube at different distances from the second connecting member; the at least two locking fins can limit the opening of the clamp body when the clamp body is at different opening and closing angles.

[0056] In some embodiments, the locking tube and the locking wing are an integrally formed structure.

[0057] In some embodiments, the locking tube and the locking wing are an integrally formed structure made of shape memory alloy through cutting and heat treatment.

[0058] One of the embodiments of the present application provides an elastic support for a tissue clamping device, which includes a first support rod, a second support rod, a first mounting portion and a second mounting portion; one end of the first support rod and the second support rod are connected to the first mounting portion; the other end of the first support rod and the second support rod are connected to the second mounting portion; the first support rod, the second support rod, the first mounting portion and the second mounting portion are an integrally formed structure.

[0059] In some embodiments, the middle parts of the first support rod and the second support rod respectively include a first arc segment, a second arc segment and a third arc segment connected in sequence; the protrusion direction of the second arc segment is opposite to the protrusion direction of the first arc segment and the third arc segment.

[0060] In some embodiments, the widths of the first support rod and the second support rod are positively correlated with the elastic force provided by the elastic support for the tissue clamping device.

[0061] In some embodiments, one end of the first support rod and the second support rod is connected to the first mounting portion via an S-rod bending structure; the other end of the first support rod and the second support rod is connected to the second mounting portion via an S-rod bending structure.

[0062] In some embodiments, the S-rod bending structure includes at least three straight rods and two bent rods, the three straight rods are parallel to each other and the three straight rods are connected end to end through the two bent rods.

[0063] In some embodiments, one end of the first support rod and the second support rod is connected to the first mounting portion via a first connecting portion; the other end of the first support rod and the second support rod is connected to the second mounting portion via a second connecting portion; and through holes are provided on the first connecting portion and the second connecting portion.

[0064] In some embodiments, the elastic support is an integrally formed structure made by cutting and heat treating a shape memory alloy tube.

[0065] In some embodiments, the first mounting portion and the second mounting portion are relatively closed after being heat-treated and shaped, and the first support rod and the second support rod have prefabricated resilience.

[0066] One of the embodiments of the present application provides a tissue clamping device, which includes an elastic support of the tissue clamping device described in any embodiment of the present application.

[0067] In some embodiments, the tissue clamping device also includes a clamp body, a first connecting member and a second connecting member; the clamp body includes a support portion, a first inner clamp arm, a first outer clamp arm, a second inner clamp arm and a second outer clamp arm, one side of the support portion is bendably connected to the first inner clamp arm and the first outer clamp arm in sequence, and the other side of the support portion is bendably connected to the second inner clamp arm and the second outer clamp arm in sequence; the clamp body is connected between the first connecting member and the second connecting member, and the relative movement of the first connecting member and the second connecting member can drive the first inner clamp arm and the second inner clamp arm to open or close relative to each other; the first mounting portion and the second mounting portion of the elastic bracket are fixedly connected to the second connecting member; the first support rod of the elastic bracket is abutted at the connection between the first inner clamp arm and the first outer clamp arm; the second support rod of the elastic bracket is abutted at the connection between the second inner clamp arm and the second outer clamp arm. BRIEF DESCRIPTION OF THE DRAWINGS

[0068] The present application will be further described in the form of exemplary embodiments, which will be described in detail by way of the accompanying drawings. These embodiments are not restrictive, and in these embodiments, the same number represents the same structure, wherein:

[0069] Figure 1 It is a schematic diagram of the structure of a tissue clamping device according to some embodiments of the present application;

[0070] Figure 2 It is a structural schematic diagram of a tissue clamping device in a folded state according to some embodiments of the present application;

[0071] Figure 3 is a top view of a tissue clamping device according to some embodiments of the present application;

[0072] Figure 4 is a structural schematic diagram of a clamp body of a tissue clamping device in a folded state according to some embodiments of the present application;

[0073] Figure 5 is a schematic structural diagram of a clamp body of a tissue clamping device in an open state according to some embodiments of the present application;

[0074] Figure 6is a schematic structural diagram of another open state of the clamp body of the tissue clamping device shown in some embodiments of the present application;

[0075] Figure 7 It is a schematic diagram of the connection between the tissue clamping clip body and the clip according to some embodiments of the present application;

[0076] Figure 8 is a schematic diagram of the front view of the S-rod bending structure of the clamp body of the tissue clamping device shown in some embodiments of the present application;

[0077] Fig. 9 is a schematic side view of an S-rod bending structure of a clamp body of a tissue clamping device according to some embodiments of the present application;

[0078] Fig.10 is a schematic diagram of a bending state of an S-bar bending structure of a clamp body of a tissue clamping device shown in some embodiments of the present application;

[0079] Fig.11 is a schematic diagram of a waist-slimming bending structure of a clamp body of a tissue clamping device according to some embodiments of the present application;

[0080] Fig.12 is a schematic structural diagram of a clamp body of a tissue clamping device according to some embodiments of the present application;

[0081] Fig.13 According to some embodiments of the present application Fig.12 A side view of a clamp body of a tissue clamping device;

[0082] Fig.14 is a schematic structural diagram of a clamp body of a tissue clamping device according to other embodiments of the present application;

[0083] Fig.15 is a schematic structural diagram of a clamp body of a tissue clamping device according to some other embodiments of the present application;

[0084] Fig.16 is a schematic diagram of the connection between the clamp body and the barbed clamp piece of the tissue clamping device shown in some embodiments of the present application;

[0085] Fig.17 is a schematic structural diagram of an integrally formed barbed clip of a tissue clamping device according to some embodiments of the present application;

[0086] Fig.18 is a schematic diagram of an integrally formed structure of a barbed clip of a tissue clamping device according to other embodiments of the present application;

[0087] Fig.19is a schematic diagram of a structure in which the barbs of the barbed clip of the tissue clamping device shown in some embodiments of the present application are detachably connected to the clamping part;

[0088] Fig. 20 is a schematic structural diagram of the barbs of the barbed clip of the tissue clamping device shown in some embodiments of the present application;

[0089] Fig.21 is a schematic structural diagram of the barbs of the barbed clip of the tissue clamping device shown in other embodiments of the present application;

[0090] Fig. 22 is a schematic diagram of the cutting shape of the barbed clip of the tissue clamping device shown in some embodiments of the present application;

[0091] Fig.23 is a schematic structural diagram of a barbed clip of a tissue clamping device according to some embodiments of the present application;

[0092] Fig.24 is a schematic structural diagram of a barbed clip of a tissue clamping device according to other embodiments of the present application;

[0093] Fig.25 is a schematic structural diagram of an inner clamping arm of a tissue clamping device according to some embodiments of the present application;

[0094] Fig.26 is a schematic diagram of the connection of the barbed clip, the inner clamp arm and the fixing ring of the tissue clamping device shown in some embodiments of the present application;

[0095] Fig. 27 It is a schematic structural diagram of a barbed clip and a clip body of a tissue clamping device according to some embodiments of the present application being integrally formed;

[0096] Fig.28 is a schematic structural diagram of a locking mechanism of a tissue clamping device according to some embodiments of the present application;

[0097] Fig.29 is a schematic structural diagram of a tissue clamping device with a locking mechanism according to some embodiments of the present application;

[0098] Fig.30 is a schematic structural diagram of a locking wing of a locking tube of a locking mechanism of a tissue clamping device according to some embodiments of the present application in a retracted state;

[0099] Fig.31 is a schematic structural diagram of a locking wing of a locking tube of a locking mechanism of a tissue clamping device according to some embodiments of the present application in an open state;

[0100] Fig.32is a schematic structural diagram of a tissue clamping device according to some embodiments of the present application when the locking mechanism is not locked;

[0101] Fig.33 is a schematic structural diagram of a tissue clamping device according to some embodiments of the present application when the locking mechanism is locked;

[0102] Fig.34 is a schematic structural diagram of an elastic support of a tissue clamping device according to some embodiments of the present application;

[0103] Fig.35 is a schematic structural diagram of an elastic support of a tissue clamping device according to other embodiments of the present application;

[0104] Fig.36 is a schematic structural diagram of an elastic support of a tissue clamping device according to some other embodiments of the present application;

[0105] Fig.37 is a schematic structural diagram of an elastic support of a tissue clamping device according to some further embodiments of the present application;

[0106] Fig.38 According to some embodiments of the present application Fig.37 A top view of the elastic support;

[0107] Fig.39 According to some embodiments of the present application Fig.37 Schematic diagram of the structure of the elastic bracket after heat treatment;

[0108] Fig.40 is a schematic structural diagram of a first connecting member of a tissue clamping device according to some embodiments of the present application;

[0109] Fig.41 is a schematic diagram of the connection between the first connecting member and the clamp body of the tissue clamping device shown in some embodiments of the present application;

[0110] Fig.42 is a schematic diagram of the connection between the clamp body and the conveying member of the tissue clamping device shown in some embodiments of the present application;

[0111] Fig.43 is a schematic structural diagram of a second connecting member of a tissue clamping device according to some embodiments of the present application;

[0112] Fig.44 is a schematic diagram of the connection between the clip body and the second connecting member according to some embodiments of the present application;

[0113] Fig.45 is a structural schematic diagram of a second connecting member of a tissue clamping device according to another embodiment of the present application;

[0114] Fig.46 It is a schematic diagram of the connection between the clip body and the second connecting member according to another embodiment of the present application.

[0115] Description of reference numerals: 100-clip body, 200-first connecting member, 300-second connecting member, 400-clip sheet, 500-locking mechanism, 600-brake lever, 700-elastic bracket, 800-detachment member, 110-support portion, 120-first inner clamp arm, 121-clamp hole, 122-fixing groove, 125-through hole, 130-second inner clamp arm, 140-first outer clamp arm, 150-second outer clamp arm, 160-first bending structure, 170-second bending structure, 202-mounting bayonet, 204-through hole, 206-bump, 302-connecting hole, 304-mounting hole, 306-bump, 410-first clamp sheet, 420-second clamp sheet, 430-fixing portion, 4 40-clamping part, 450-barb, 451-circlip, 452-through hole, 460-fixing ring, 510-locking tube, 520-locking piece, 530-sleeve, 511-locking wing, 710-first support rod, 712-first arc segment, 714-second arc segment, 716-third arc segment, 720-second support rod, 730-first mounting part, 740-second mounting part, 750-first connecting part, 760-second connecting part, 810-main body, 820-first connecting plate, 830-second connecting plate, 840-fixing support rod, 910-S rod bending structure, 920-slim waist bending structure, 911-straight rod, 912-bent rod, 913-connecting rod, 930-through hole. DETAILED DESCRIPTION

[0116] In order to make the purpose, technical solution and advantages of the present application more clearly understood, the present application is further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present application and are not used to limit the present application.

[0117] On the contrary, the present application covers any substitution, modification, equivalent method and scheme made on the essence and scope of the present application as defined by the claims. Further, in order to make the public have a better understanding of the present application, some specific details are described in detail in the detailed description of the present application below. Those skilled in the art can fully understand the present application without the description of these details.

[0118] The embodiment of the present application relates to a tissue clamping device, wherein the inner clamping arms of the clamp body of the tissue clamping device can be relatively opened or closed, and can clamp tissue after cooperating with the clamping piece. The tissue clamping device can be applied to a variety of occasions, for example, it can be used to clamp tissues such as heart valves (such as mitral valves, tricuspid valves) or vascular valves, and can reach a predetermined position through a variety of paths during the process of tissue clamping, and the present application does not limit this.

[0119] Figure 1 is a schematic structural diagram of a tissue clamping device according to some embodiments of the present application; Figure 2 is a schematic structural diagram of a tissue clamping device in a folded state according to some embodiments of the present application; Figure 3 is a top view of a tissue clamping device according to some embodiments of the present application; Figure 4 is a structural schematic diagram of a clamp body of a tissue clamping device in a folded state according to some embodiments of the present application; Figure 5 is a schematic structural diagram of a clamp body of a tissue clamping device in an open state according to some embodiments of the present application; Figure 6 is a schematic structural diagram of another open state of the clamp body of the tissue clamping device shown in some embodiments of the present application; Figure 7 Schematic diagram of the connection between the tissue clamp body and the clamping piece according to some embodiments of the present application. Figure 1-7 The clamp body for the tissue clamping device involved in the embodiment of the present application is described in detail. It should be noted that the following embodiments are only used to explain the present application and do not constitute a limitation on the present application.

[0120] In the embodiments of the present application, Figure 1-7As shown, the tissue clamping device may include a clamp body 100, a first connecting member 200, a second connecting member 300 and a clamping piece 400. The clamp body 100 may include a supporting portion 110, a first inner clamp arm 120, a first outer clamp arm 140, a second inner clamp arm 130 and a second outer clamp arm 150, one side of the supporting portion 110 is bendably connected to the first inner clamp arm 120 and the first outer clamp arm 140 in sequence, and the other side of the supporting portion 110 is bendably connected to the second inner clamp arm 130 and the second outer clamp arm 150 in sequence. The support portion 110 and the first inner clamp arm 120 are bendably connected, and the support portion 110 and the second inner clamp arm 130 are bendably connected, which can be understood as: the connection between the first inner clamp arm 120 and the support portion 110 and the connection between the second inner clamp arm 130 and the support portion 110 can be bent, the first inner clamp arm 120 and the second inner clamp arm 130 can be bent relative to the support portion 110 and relatively closed, and the first inner clamp arm 120 and the second inner clamp arm 130 can also be bent away from the support portion 110 and relatively open. The first inner clamp arm 120 and the first outer clamp arm 140 are connected in a bendable manner, and the second inner clamp arm 130 and the second outer clamp arm 150 are connected in a bendable manner, which can be understood as follows: the connection between the first inner clamp arm 120 and the first outer clamp arm 140 and the connection between the second inner clamp arm 130 and the second outer clamp arm 150 can be bent, the angle between the first inner clamp arm 120 and the first outer clamp arm 140 can be changed, and the angle between the second inner clamp arm 130 and the second outer clamp arm 150 can be changed. In some embodiments, the number of inner clamp arms and outer clamp arms can be increased as needed, such as further including a third inner clamp arm, a fourth inner clamp arm, a third outer clamp arm and a fourth outer clamp arm, and the support portion 110 can be connected to the third inner clamp arm and the third outer clamp arm in sequence in a bendable manner, and the support portion 110 can be connected to the fourth inner clamp arm and the fourth outer clamp arm in sequence in a bendable manner.

[0121] In some embodiments, the clip body 100 can be an integrally formed structure. Specifically, during the manufacturing process of the clip body 100, a metal tube can be cut (for example, laser cut) to form the clip body 100. In some alternative embodiments, the clip body 100 can also be made by weaving metal wires. The clip body 100 can be connected between the first connector 200 and the second connector 300, and the relative movement of the first connector 200 and the second connector 300 can drive the first inner clamp arm 120 and the second inner clamp arm 130 to open or close relative to each other. The state where the first inner clamp arm 120 and the second inner clamp arm 130 are relatively closed is shown in FIG. Figure 4 The first inner clamp arm 120 and the second inner clamp arm 130 can be opened at any angle, such as 40°, 90°, 120°, 180°, 270°, 350°, 360°, etc. For example, Figure 5 The figure shows a state where the first inner clamp arm 120 and the second inner clamp arm 130 are relatively opened 180°; Figure 6The first inner clamp arm 120 and the second inner clamp arm 130 are shown in a state of being relatively opened nearly 360°. Figure 1-2 As shown, one end of the support portion 110 (the upper end shown in the figure) is connected (such as fixedly connected) to the first connecting member 200, and one end of the first outer clamp arm 140 (the lower end shown in the figure) and one end of the second outer clamp arm 150 (the lower end shown in the figure) are respectively connected (such as fixedly connected) to the second connecting member 300. Through such an arrangement, when the second connecting member 300 moves relative to the first connecting member 200, the second connecting member 300 can move relative to the support portion 110. When the second connecting member 300 moves away from the support portion 110, driven by the second connecting member 300, the first outer clamp arm 140 and the second outer clamp arm 150 can respectively pull the first inner clamp arm 120 and the second inner clamp arm 130 to open relatively. In some embodiments, in order to make the first inner clamp arm 120 and the second inner clamp arm 130 open at a larger angle range, one end of the first outer clamp arm 140 and one end of the second outer clamp arm 150 can be bendably connected to the second connecting member 300.

[0122] In some embodiments, Figure 7 As shown, the clip 400 may include a first clip 410 disposed on the first inner clamp arm 120 and a second clip 420 disposed on the second inner clamp arm 130. The first clip 410 and the second clip 420 can be opened and closed relative to the first inner clamp arm 120 and the second inner clamp arm 130, respectively, and enable the tissue to be clamped between the first clip 410 and the first inner clamp arm 120 and between the second clip 420 and the second inner clamp arm 130. In some embodiments, the clip 400 may be a barbed clip. In some embodiments, the clip 400 may also be other types of clips. For example, a barb and / or a protrusion may be provided on one side of the clip 400 facing the inner clamp arm (such as the first inner clamp arm 120 or the second inner clamp arm 130).

[0123] In some embodiments, the tissue clamping device may further include a first control mechanism for controlling the second connecting member 300 to move relative to the first connecting member 200, so as to control the first inner clamp arm 120 and the second inner clamp arm 130 to close or open relative to each other. The first control mechanism may include a brake rod 600, which can pass through the support portion 110 and be detachably connected (such as threaded connection) to the second connecting member 300, and the brake rod 600 can push and pull the second connecting member 300 to move relative to the first connecting member 200. In some embodiments, the tissue clamping device may further include a second control mechanism for controlling the first clamp 410 and the second clamp 420 to open or close relative to the first inner clamp arm 120 and the second inner clamp arm 130, respectively. The second control mechanism may include a first traction rope connected to the first clamp 410 and a second traction rope connected to the second clamp 420. For example, the first traction rope may be connected to the through hole at the opening and closing end of the first clamp 410, and the second traction rope may be connected to the through hole at the opening and closing end of the second clamp 420. The first clip 410 and the second clip 420 can be prefabricated with a rebound force respectively directed toward the first inner clamp arm 120 and the second inner clamp arm 130. When the first traction rope and / or the second traction rope are pulled, the first clip and / or the second clip can be opened relative to the first inner clamp arm 120 and the second inner clamp arm 130 under the pulling force of the traction rope; when the first traction rope and / or the second traction rope are relaxed, the first clip 410 can be closed with the first inner clamp arm 120 under the rebound force, and / or the second clip 420 can be closed with the second inner clamp arm 130 under the rebound force.

[0124] In some embodiments, one side of the support portion 110 is connected to the first inner clamp arm 120 through a first bending structure 160, and the other side of the support portion 110 is connected to the second inner clamp arm 130 through a first bending structure 160. The first bending structure 160 can be an S-bar bending structure 910 or a thin waist bending structure 920. The first inner clamp arm 120 is connected to the first outer clamp arm 140 through a second bending structure 170, and the second inner clamp arm 130 is connected to the second outer clamp arm 150 through a second bending structure 170. The second bending structure 170 can be an S-bar bending structure 910 or a thin waist bending structure 920. The first bending structure 160 and the second bending structure 170 can be bent by themselves due to their own structural characteristics and / or material characteristics. The specific structures of the first bending structure 160 and the second bending structure 170 can be the same or different. For example, when the first bending structure 160 is an S-bar bending structure 910, the second bending structure 170 can be an S-bar bending structure 910 or a thin waist bending structure 920. Both the S-bar bending structure 910 and the thin waist bending structure 920 can be heat treated. The S-bar bending structure 910 and the thin waist bending structure 920 are easy to deform by heat treatment, and can make the stress distribution at the bending part uniform, and are not easy to break after multiple bendings, thereby extending the service life of the clip body 100.

[0125] Figure 8 It is a schematic diagram of the front view of the S-rod bending structure of the clamp body of the tissue clamping device shown in some embodiments of the present application. Fig. 9 It is a side view structural schematic diagram of the S-rod bending structure of the clamp body of the tissue clamping device shown in some embodiments of the present application. Fig.10 Schematic diagram of the bending state of the S-bar bending structure of the clamp body of the tissue clamping device shown in some embodiments of the present application. Figure 8-10 As shown, the S-bar bending structure 910 can be understood as a bendable bar structure similar to an "S" shape. In some embodiments, the S-bar bending structure 910 can include at least three straight bars 911 and two curved bars 912. The three straight bars 911 are parallel to each other and are connected end to end through the two curved bars 912. Figure 8-9 In the S-bar bending structure 910 shown, a single row (such as Figure 8 The S-bar bending structure 910 may include 7 straight bars 911 and 6 curved bars 912, wherein the 7 straight bars 911 are parallel to each other and connected end to end through the 6 curved bars 912. In some embodiments, the number of straight bars 911 and curved bars 912 of the S-bar bending structure 910 may be other numbers. Fig.10 The S-bar bending structure 910 is shown. Figure 8-9 The S-bar bending structure 910 is shown when it is not bent. Fig.10 As shown in FIG. 1 , when the S-bar bending structure 910 is bent, each straight bar 911 remains relatively parallel, and the S-bar bending structure 910 is bent at each curved bar 912. With such an arrangement, the S-bar bending structure 910 can be more easily bent. In some embodiments, the S-bar bending structure 910 can be arranged in multiple rows (e.g., 2 rows, 3 rows, etc.), such as Figure 8 As shown, it includes two upper and lower rows of S-bar bending structures 910. Arranging the S-bar bending structures 910 in multiple rows can make the S-bar bending structures 910 more stable when bending, such as avoiding lateral bending and / or avoiding twisting between multiple straight rods 911 when bending. In some embodiments, when the S-bar bending structures 910 are arranged in multiple rows, the bending rods 912 of two adjacent rows of S-bar bending structures 910 can be connected by connecting rods 913 (such as Figure 8 As shown). By setting a connecting rod 913 to connect two adjacent rows of S-rod bending structures 910, the stability of the S-rod bending structure 910 when bending can be effectively improved. In some embodiments, the S-rod bending structure 910 can be cut from a plate or tube of a shape memory alloy. The S-rod bending structure 910 after heat treatment and shaping can have prefabricated resilience. The S-rod bending structure 910 is easy to bend and has good resilience and excellent fatigue resistance.

[0126] Fig.11 Schematic diagram of the waist-slimming bending structure of the clamp body of the tissue clamping device shown in some embodiments of the present application. Fig.11 As shown, the first inner clamp arm 120 and the first outer clamp arm 140 can be connected by a slim waist bending structure 920. The slim waist bending structure 920 can be understood as a bendable rod-shaped structure whose middle width is smaller than the width at both ends. By setting the middle width of the slim waist bending structure 920 to be smaller than the width at both ends, the middle part of the slim waist bending structure 920 can be made easier to bend. The slim waist bending structure 920 can be cut from a plate or tube of a shape memory alloy. The slim waist bending structure 920 after heat treatment and shaping can have prefabricated resilience. In some alternative embodiments, the slim waist bending structure 920 can also be understood as a bendable structure whose cross-sectional area in the middle is smaller than the cross-sectional area at both ends (such as Fig.15 The second bending structure 170 is shown in FIG.

[0127] Fig.12 is a schematic structural diagram of a clamp body of a tissue clamping device according to some embodiments of the present application; Fig.13 According to some embodiments of the present application Fig.12 A side view of a clamp body of a tissue clamping device; Fig.14 is a schematic structural diagram of a clamp body of a tissue clamping device according to other embodiments of the present application; Fig.15 is a schematic diagram of the structure of the clamp body of the tissue clamping device according to some other embodiments of the present application. Figure 12-15 As shown, the support portion 110 can be a grid structure. The grid structure can include a combination of one or more of a diamond grid, a circular grid, a rectangular grid, a square grid, a triangular grid or a regular polygonal grid. In some embodiments, the grid structure can determine the hardness of the support portion 110, and those skilled in the art can design the size and shape of the grid according to the hardness requirements of the support portion 110. For example, when the support portion 110 is required to be harder, a triangular grid can be selected or the grid can be set to be smaller, and when the support portion 110 is required to be softer, a regular polygonal grid can be selected or the grid can be set to be larger. By setting the support portion 110 to a grid structure, the heat-treated support portion can also be made elastic, so as to pass through the delivery tube when the tissue clamping device is transported. In addition, the support portion 110 with a grid structure can also effectively fill the space between the first inner clamp arm 120 and the second inner clamp arm 130, and can prevent the formation of thrombus after the tissue clamping device clamps the tissue.

[0128] In some embodiments, the cross-sectional shape of the support portion 110 may be circular or elliptical, and the cross-sectional area of ​​the middle portion of the support portion 110 may be larger than the cross-sectional area of ​​the two ends thereof. The cross section is a plane perpendicular to the brake rod 600. For example, the shape of the support portion 110 may be approximately spherical or ellipsoidal. Through such a design, the beneficial effects that may be brought about include but are not limited to: making the support portion 110 less likely to damage the tissue; facilitating the delivery of the tissue clamping device to the tissue to be clamped through the pipe of the delivery system; and being able to form effective support for the clamped tissue. In some embodiments, the support portion 110 may also be pear-shaped, cylindrical, and the like. Those skilled in the art may determine that the support portion 110 of the clamp body 100 has different shapes according to the specific conditions of the tissue to be clamped (such as the shape of the apposition edge of the mitral valve leaflet), so that the shape of the support portion 110 is more in line with the shape of the tissue (such as the apposition edge of the mitral valve leaflet), so that the clamping effect is better.

[0129] In some embodiments, Fig.12 and Fig.14 As shown, the first outer clamp arm 140 and the second outer clamp arm 150 may include a plurality of through holes 930, and the plurality of through holes 930 can assist the first outer clamp arm 140 and the second outer clamp arm 150 in deformation during the heat treatment process. In some embodiments, each through hole can extend along the width direction of the first outer clamp arm 140 and the second outer clamp arm 150, and the plurality of through holes can be arranged at intervals along the length direction of the first outer clamp arm 140 and the second outer clamp arm 150. In some alternative embodiments, the plurality of through holes 930 can also be other shapes and / or other arrangements. For example, the plurality of through holes 930 can be square holes, round holes, polygonal holes, etc. For another example, the plurality of through holes 930 can be arranged in multiple rows along the width direction of the first outer clamp arm 140 and the second outer clamp arm 150. In some embodiments, when the first inner clamp arm 120 and the second inner clamp arm 130 are closed, in order to enable the first outer clamp arm 140 and the second outer clamp arm 150 to better cover the support portion 110, the first inner clamp arm 120 and the second inner clamp arm 130, the first outer clamp arm 140 and the second outer clamp arm 150 can be bent and deformed into an arc shape along the length direction after heat treatment (such as Figure 4-5 shown).

[0130] In some embodiments, the clip body 100 may be an integrally formed structure made by cutting and heat treating a shape memory alloy tube. The shape memory alloy may include nickel-titanium alloy or cobalt-chromium alloy. Fig.13 Shown Fig.12 A side view of the clamp body of the tissue clamping device. Fig.13 It can be seen that Fig.12 The main body of the clip is a tube-integrated cutting and molding structure. The tube cutting method may include laser cutting, water jet cutting, etc. Figure 14-15The schematic diagrams of the structure of the clip body are all integrally formed. Figure 12-15 On the basis of the one-piece formed clip body 100 shown, various parts (such as the support part, the first bending structure 160, the second bending structure 170, the first outer clamp arm 140 or the second outer clamp arm 150, etc.) can be deformed during the heat treatment of the clip body 100. For example, during the heat treatment process, the two ends of the support part 110 are retracted inward, so that the cross-sectional area of ​​the middle part of the support part is larger than the cross-sectional area of ​​the two ends. For another example, during the heat treatment process, the first outer clamp arm 140 and the second outer clamp arm 150 are bent into an arc shape, and the first bending structure 160 and the second bending structure 170 are bent. When the clip body 100 is heat treated, various parts of the clip body 100 can be deformed by a mold. Shape memory alloys can remember the shape after heat treatment (such as Figure 4 When the tissue is clamped, the clamp body 100 will have a restoring force to return to the original shape and can clamp the tissue. It is worth noting that Figure 1-7 The clip body 100 shown is only used to illustrate the general shape of the clip body 100, and does not mean that the final shape of the clip body is the same as that of the clip body 100. Figure 1-7 For example, in Figure 1-7 On the basis of the clip body 100 shown, the support portion 110 of the clip body 100 may be a grid structure, and the first bending structure 160 and the second bending structure 170 may be an S-bar bending structure 910 or a waist-slimming bending structure 920 .

[0131] In some embodiments, the clip 400 may include a first clip 410 disposed on the first inner clip arm 120 and a second clip 420 disposed on the second inner clip arm 130, and the first clip 410 may be the same as the second clip 420. Specifically, the clip 400 may include a fixing portion 430 and a clamping portion 440, and the fixing portion 430 and the clamping portion 440 may be connected via a bending portion. In some embodiments, the clip 400 may be a barbed clip, and the barbed clip may include a fixing portion 430, a clamping portion 440, and a barb 450. One end of the clamping portion 440 may be connected to one end of the fixing portion 430 via a bending portion, and the other end of the clamping portion 440 may be provided with a barb 450. Fig.16 Schematic diagram of the connection between the clamp body and the barbed clip of the tissue clamping device shown in some embodiments of the present application. Fig.16As shown, the barb 450 can be located on the side of the clamping portion 440 of the clip 400 (such as the first clip 410 or the second clip 420) facing the inner clamp arm (such as the first inner clamp arm 120 or the second inner clamp arm 130). The fixing portion 430 can be used to fix the clip 400 (such as the first clip 410 or the second clip 420) on the inner clamp arm (such as the first inner clamp arm 120 or the second inner clamp arm 130). The clamping portion 440 can be used to cooperate with the inner clamp arm (such as the first inner clamp arm 120 or the second inner clamp arm 130) to clamp the tissue. One end of the fixing portion 430 can be connected to one end of the clamping portion 440 through a bending portion, so that the clip 400 (such as the first clip 410 or the second clip 420) can be opened and closed relative to the inner clamp arm (such as the first inner clamp arm 120 or the second inner clamp arm 130). The provision of the barbs 450 can effectively prevent the tissue from slipping out from between the clamping piece 400 and the inner clamping arm, and can make the clamping of the tissue by the tissue clamping device more stable.

[0132] In some embodiments, the bending portion may be an S-bar bending structure 910 (eg Fig.19 as well as Figure 22-24 As shown). The S-rod bending structure 910 is easy to deform by heat treatment, and can make the stress distribution at the bending part uniform, and is not easy to break after multiple bending. In addition, by setting the bending part as the S-rod bending structure 910, the clip 400 can be bent smoothly and is not easy to break during the bending process. In some embodiments, the S-rod bending structure 910 can include at least three straight rods 911 and two bent rods 912. The three straight rods 911 are parallel to each other and the three straight rods 911 are connected end to end through the two bent rods 912. For more details about the S-rod bending structure 910, please refer to Figure 8-10 and its related description.

[0133] In some embodiments, the fixing portion 430, the clamping portion 440 and the barb 450 can be an integrally formed structure. Specifically, the fixing portion 430, the clamping portion 440 and the barb 450 can be integrally formed by cutting (such as laser cutting) a plate or a tube. Through the integral formation of the fixing portion 430, the clamping portion 440 and the barb 450, the barb clip structure can be stable, the components can be reliably connected and it is easy to manufacture. In some embodiments, the barb 450 can include multiple barbs, such as 3, 4, 5, 7, 10, etc. The multiple barbs can be arranged in a row or in multiple rows. The outer wall of the barb can be a plane or a circular arc surface. Fig.17 9 is a schematic diagram of the structure of the integrally formed barbed clip of the tissue clamping device according to some embodiments of the present application. In some embodiments, at least one barbed strip can be connected to the other end of the clamping portion 440 through the S-bar bending structure 910. Preferably, as Fig.17As shown, all the barbs can be connected to the other end of the clamping portion 440 via the S-bar bending structure 910. The design of connecting with the S-bar bending structure 910 can facilitate bending the barbs during the heat treatment process, such as bending the barbs to form 90° with the clamping portion 440. Fig.18 is a schematic diagram of the structure of an integrally formed barbed clip of a tissue clamping device according to other embodiments of the present application. Fig.18 As shown, at least one barb (such as all barbs) may be provided with a through hole 452. In some embodiments, the through hole 452 may penetrate the barb along the thickness direction of the barb. The number of through holes on each barb may be one or more. The shape of the through hole may include barb-shaped, square, circular, triangular, etc. Preferably, each barb may include a through hole 452, and the shape of the through hole is similar to the shape of the barb. During the production process of the barbed clip, the design of the through hole can facilitate the bending and forming of the barb during the heat treatment process. In some alternative embodiments, the through hole on the barb may also penetrate along other directions (such as the width direction of the barb).

[0134] In some embodiments, the barb 450 may be detachably connected to the other end of the clamping portion 440. Those skilled in the art may choose whether to install the barb 450 on the clamping portion 440, or which barb 450 to install on the clamping portion 440 according to actual needs. Fig.19 is a schematic diagram of a structure in which the barbs of the barbed clip of the tissue clamping device shown in some embodiments of the present application are detachably connected to the clamping part; Fig. 20 is a schematic structural diagram of the barbs of the barbed clip of the tissue clamping device shown in some embodiments of the present application; Fig.21 Schematic diagram of the structure of the barbs of the barbed clip of the tissue clamping device according to other embodiments of the present application. Figure 19-21 As shown, the other end of the clamping portion 440 may include a slot, and the barb 450 may include a snap ring 451, and the snap ring 451 can be snapped into the slot. With such an arrangement, the barb 450 can be conveniently and securely mounted on the clamping portion 440. In addition, the barb 450 and the clamping portion 440 are detachably connected to avoid the problem that the barb may be difficult to bend during heat treatment. In some embodiments, the snap ring 451 can be made of an elastic material or a superelastic metal (such as nickel-titanium alloy), so that the snap ring 451 can be easily mounted on the slot. In some embodiments, as Figure 20-21 As shown, the opposite sides of the clamp ring 451 can be straight lines or arcs to be suitable for different types of clamping parts 440 (such as clamping parts cut from plates or clamping parts cut from tubes). In some embodiments, the number, shape and arrangement of the barbs on the barbs 450 can be adjusted according to actual conditions (such as the characteristics of the clamped tissue).

[0135] In some embodiments, the fixing portion 430 and the clamping portion 440 may be an integrally formed structure made of a shape memory alloy after cutting and heat treatment. The shape memory alloy may include nickel-titanium alloy or cobalt-chromium alloy. Fig. 22 is a schematic diagram of the cutting shape of the barbed clip of the tissue clamping device shown in some embodiments of the present application; Fig.23 is a schematic structural diagram of a barbed clip of a tissue clamping device according to some embodiments of the present application; Fig.24 Schematic diagram of the structure of the barbed clip of the tissue clamping device according to other embodiments of the present application. Fig. 22 As shown, the barbed clip can be cut and formed in one piece from a shape memory alloy sheet. Fig.23 and Fig.24 As shown, the fixing portion 430 and the clamping portion 440 of the integrally cut and formed barbed clip can be at a certain angle after heat treatment and finalization, and the bent portion will have a prefabricated resilience. With such a design, the clamping force of the barbed clip and the inner clamp arm (such as the first inner clamp arm 120 or the second inner clamp arm 130) on the tissue can be increased. It should be noted that the fixing portion 430 and the clamping portion 440 being at a certain angle can be understood as the fixing portion 430 and the clamping portion 440 being not parallel. Preferably, after heat treatment and finalization, the fixing portion 430 can be bent into the inner hole of the clamping portion 440 (such as Figure 23-24 ), that is, the flip angle of the fixing portion 430 relative to the clamping portion 440 during the heat treatment process is greater than 180°. In some embodiments, those skilled in the art can determine the angle between the fixing portion 430 and the clamping portion 440 according to factors such as the required clamping force and the size of the tissue clamping device. For example, when the fixing portion 430 is bent into the inner hole of the clamping portion 440, the angle between the fixing portion 430 and the clamping portion 440 can be designed to be 15°, 20°, 30°, etc.

[0136] In some embodiments, Fig.16 As shown, the inner clamp arm (such as the first inner clamp arm 120 or the second inner clamp arm 130) may be provided with a through hole 125 that matches the barb 450. In some embodiments, the number of through holes 125 may be equal to the number of barbed strips (such as 4 for each). In some embodiments, the number of through holes 125 may also be unequal to the number of barbed strips. For example, the through hole may be a hole extending along the width direction of the inner clamp arm, and the hole can accommodate all barbed strips. By providing the through hole 125 on the inner clamp arm, when the barbed clip is closed, the barb 450 can be inserted into the through hole 125 of the inner clamp arm, which makes it easier for the barbed clip to clamp tissue, and the clamping of the tissue after clamping is also more secure.

[0137] Fig.25 is a schematic structural diagram of an inner clamping arm of a tissue clamping device according to some embodiments of the present application; Fig.26 Schematic diagram of the connection between the barbed clip, the inner clamp arm and the fixing ring of the tissue clamping device shown in some embodiments of the present application. Fig.25 and Fig.26 As shown, the inner clamp arm (such as the first inner clamp arm 120 or the second inner clamp arm 130, the first inner clamp arm 120 is taken as an example in the figure) may be provided with a clamping hole 121 that matches the fixing portion 430 of the barbed clamp, and the fixing portion 430 can be embedded in the clamping hole 121. Specifically, the shape of the clamping hole 121 can be consistent with the shape of the fixing portion 430. In some embodiments, the first inner clamp arm 120 and the second inner clamp arm 130 may also be provided with a fixing groove 122, and the tissue clamping device may further include a fixing ring 460, which can be engaged with the fixing groove 122 to limit the fixing portion 430 from being separated from the clamping hole 121. Specifically, the fixing groove 122 can be symmetrically arranged on both sides in the width direction of the inner clamp arm (such as Fig.25 As shown). In the actual installation process, when the clip body 100 is an integrally formed structure, the fixing ring 460 can be respectively sleeved on the first inner clamp arm 120 and the second inner clamp arm 130 through the first outer clamp arm 150 and the second outer clamp arm 160. The fixing ring 460 can be made of an elastic material or a superelastic alloy (such as nickel-titanium alloy). Through the cooperation between the clamp hole 121 and the fixing portion 430 and the cooperation between the fixing groove 122 and the fixing ring 460, the installation of the barbed clip can be convenient and firm. In some alternative embodiments, after the fixing portion 430 is embedded in the clamp hole 121, the fixing portion 430 can be directly fixed in the clamp hole 121 by bonding or welding (such as laser welding) (for example, gluing or welding along the gap between the fixing portion 430 and the clamp hole 121). In other embodiments, the barbed clip can also be connected to the inner clamp arm by bonding, welding, riveting, threading or clamping.

[0138] In some embodiments, the fixing portion 430 and the clamping portion 440 of the barbed clip may be integrally formed with the clip body 100 . Fig. 27 1 is a schematic diagram of a structure in which the barbed clip and the clip body of a tissue clamping device are integrally formed according to some embodiments of the present application. Fig. 27In the illustrated embodiment, the fixing portion 430, the clamping portion 440 and the barbs 450 of the barbed clip can be integrally formed with the clip body 100. Specifically, when cutting the clip body 100, the shapes of the clamping portion 440 and the barbs 450 of the barbed clip can be cut on the inner clamp arm (such as the first inner clamp arm 120 or the second inner clamp arm 130) of the clip body 100, and one end of the cut clamping portion 440 is still connected to the inner clamp arm (at this time, one end of the fixing portion 430 of the barbed clip is also still connected to the inner clamp arm). In some embodiments, after the clamping portion 440 and the barbs 450 are integrally cut, the barbs 450 can be bent by heat treatment. In some alternative embodiments, the clamping portion 440 can be cut only on the inner clamp arm, and the barbs can be installed at the other end of the cut clamping portion 440. By integrally forming all or part of the barbed clip with the inner clamp arm, the connection between the barbed clip and the inner clamp arm can be made more reliable, which is beneficial to improving the clamping stability of the tissue clamping device; at the same time, it can simplify the assembly process of the tissue clamping device and improve production efficiency.

[0139] In some embodiments, the tissue clamping device may include a locking mechanism 500 . Fig.28 is a schematic structural diagram of a locking mechanism of a tissue clamping device according to some embodiments of the present application; Fig.29 is a schematic diagram of the structure of a tissue clamping device with a locking mechanism according to some embodiments of the present application. Fig.28 and Fig.29 As shown, the locking mechanism 500 may include a locking tube 510 and a locking member 520, and one end (the lower end as shown) of the locking tube 510 may be fixedly connected to the second connecting member 300. The outer wall of the locking tube 510 may be provided with a locking wing 511, which can be used to limit the opening of the clip body. Fig.30 is a schematic structural diagram of a locking wing of a tissue clamping device in some embodiments of the present application in a retracted state; Fig.31 1 is a schematic diagram of the structure of the locking wing of the tissue clamping device shown in some embodiments of the present application in an open state. Figure 30-31 As shown, the locking wing 511 can switch between a retracted state and an open state. When the locking wing 511 is opened, the opening faces the second connecting member 300. When there is no external force, the locking wing 511 is opened by default. In some embodiments, the locking member 520 can be fixed to the support portion 110 of the clip body. For example, the locking member 520 can be fixed in the inner cavity of the support portion 110 by gluing, welding (such as laser welding), etc. The locking wing 511 can limit the movement of the locking member 520 to limit the opening of the clip body (that is, the first inner clamp arm 120 and the second inner clamp arm 130 are relatively opened). As shown Fig.28As shown, when the locking member 520 moves in a direction away from the second connecting member 300, the opened locking fin 511 can abut against the locking member 520 to limit the movement of the locking member 520. In some alternative embodiments, the locking fin 511 can also directly limit the opening of the clip body by limiting the movement of other parts of the clip body (such as the support portion 110). For example, the opened locking fin 511 can directly abut against the support portion 110.

[0140] In some embodiments, the locking mechanism 500 can cooperate with a first control mechanism for controlling the relative closing or opening of the first inner clamp arm 120 and the second inner clamp arm 130 to limit the relative opening of the first inner clamp arm 120 and the second inner clamp arm 130. Fig.28 The upper end of the second connecting member 300 shown in the figure can be detachably connected to the brake rod 600. The brake rod 600 can control the movement of the second connecting member 300 relative to the first connecting member 200 through the locking tube 510. The locking fin 511 can limit the relative movement of the locking member 520 (or the supporting portion 110) and the locking tube 510 (or the second connecting member 300), thereby limiting the relative opening of the first inner clamp arm 120 and the second inner clamp arm 130. By setting the locking mechanism 500, the tissue clamping device can stably maintain the clamping state after completing the clamping of the tissue, and can effectively prevent the tissue clamping device from opening due to the impact of blood flow. It can be understood that the locking fin 511 can be used to limit the relative opening of the first inner clamp arm 120 and the second inner clamp arm 130, but will not limit the closing of the first inner clamp arm 120 and the second inner clamp arm 130.

[0141] In some embodiments, the locking mechanism 500 may further include a sleeve 530, which can be sleeved on the outside of the locking tube 510 and retract the locking wing 511. Specifically, when the locking wing 511 is located in the sleeve 530, the locking wing 511 is forced to retract, and when the locking wing 511 is exposed outside the sleeve 530, the locking wing 511 automatically opens. In some embodiments, the brake rod 600 of the tissue clamping device can be fixedly connected to the sleeve 530 (such as welding, gluing, threaded connection, etc.), and the brake rod 600 can be detachably connected to the locking tube 510 (such as threaded connection). When the brake rod 600 is connected to the locking tube 510, the sleeve 530 can retract the locking wing 511; when the brake rod 600 is disengaged from the locking tube 510, the sleeve 530 releases the effect on the locking wing 511, and the locking wing 511 opens. Fig.32 and Fig.33 As shown, Fig.32 This is a schematic diagram of the structure when the locking wing 511 is retracted and the locking mechanism 500 is not locked. Fig.33 This is a schematic diagram of the structure when the locking wing 511 is open and the locking mechanism 500 is locked. Figure 32-33In the embodiment shown, the inner diameter of the locking member 520 is larger than the outer diameter of the sleeve 530, and the locking fin 511 after opening cannot pass through the inner hole of the locking member 520. When the brake rod 600 is connected to the locking tube 510, the sleeve 530 covers the locking fin 511 on the locking tube 510, and the locking member 520 can slide freely on the locking tube 510 and the sleeve 530, and the tissue clamping device can complete the clamping operation of the tissue in this state. When the tissue clamping device completes the clamping of the tissue, the brake rod 600 and the sleeve 530 can be withdrawn, and at this time, the sleeve 530 releases the effect on the locking fin 511, and the locking fin 511 originally located in the sleeve 530 is exposed outside the sleeve 530 and opens, and the locking fin 511 can limit the movement of the locking member 520, thereby limiting the opening of the clamp body.

[0142] In some embodiments, the brake rod 600 and the locking tube 510 can be connected by threads. For example, one end of the brake rod 600 connected to the locking tube 510 can be provided with external threads, and the locking tube 510 can be provided with internal threads correspondingly. The sleeve 530 is sleeved outside the brake rod 600 and can cover the external threads of the brake rod 600. Through such a configuration, the brake rod 600 and the locking tube 510 can be easily separated. In other embodiments, the brake rod 600 and the locking tube 510 can also be detachably connected by a snap-on method.

[0143] In some embodiments, the locking fins 511 may include at least two pieces, and the at least two locking fins 511 are symmetrically arranged on the outer wall of the locking tube 510 at the same distance as the second connecting member 300. It should be noted that the number of the locking fins 511 can be 2, 3 or 4. 2 or 4 locking fins 511 can be arranged in an axisymmetric (or centrosymmetric) manner on the outer wall of the locking tube 510, and 3 locking fins 511 can be arranged in a centrosymmetric manner (such as 120 degrees apart) on the outer wall of the locking tube 510. By limiting the movement of the locking member 520 by at least two symmetrically arranged locking fins 511, each locking fin 511 can be uniformly stressed, thereby improving the stability of the locking mechanism 500 and extending the service life of the locking mechanism 500.

[0144] In some embodiments, the locking fins 511 may include at least two pieces, and the at least two locking fins 511 may be arranged on the outer wall of the locking tube 510 at different distances from the second connecting member 300; the at least two locking fins 511 can limit the opening of the clip body 100 when the clip body is at different opening and closing angles (such as the first inner clamp arm 120 and the second inner clamp arm 130 are relatively opened to different angles). It can be understood that when the first inner clamp arm 120 and the second inner clamp arm 130 are opened to different angles, the distance between the locking member 520 and the second connecting member 300 is different, so the locking fins 511 at different distances from the second connecting member 300 need to abut against the locking member 520 to limit the movement of the locking member 520 (support portion 110) relative to the second connecting member 300. In actual operation, due to the differences in pathological conditions and physiological structures of different patients or the differences in the clamped tissues, the opening and closing angles of the clamp body 100 of the tissue clamping device may be different after clamping the tissue and retracting it. Through such a setting, the tissue clamping device with a locking mechanism 500 can be suitable for different patients or different tissues.

[0145] In some embodiments, the locking tube 510 and the locking fin 511 may be an integrally formed structure. For example, the locking tube 510 with the locking fin 511 may be formed by cutting (such as laser cutting) a pipe fitting to form an incision. In some embodiments, the locking tube 510 and the locking fin 511 may be an integrally formed structure made by cutting and heat treating a shape memory alloy. The shape memory alloy may be a nickel-titanium alloy or a cobalt-chromium alloy, etc. After the shape memory alloy pipe is cut to form the locking fin 511 on the locking tube 510, the connection between the locking fin 511 and the locking tube 510 is heat treated and shaped so that the locking fin 511 opens outward. After heat treatment and shaping, the connection between the locking fin 511 and the locking tube 510 will have a prefabricated resilience, which can ensure that the locking fin 511 automatically opens when it is exposed outside the sleeve 530. In some alternative embodiments, the locking tube 510 and the locking fin 511 may also be two parts connected to each other. For example, the locking fin 511 may be an elastic sheet, which may be fixedly connected to the locking tube by bonding, welding (such as laser welding), etc.

[0146] In some embodiments, the tissue clamping device may include an elastic support 700. Figure 34-37 Schematic diagram of the structure of the elastic support of the tissue clamping device shown in various embodiments of the present application. Figure 34-37As shown, the elastic bracket 700 may include a first support rod 710, a second support rod 720, a first mounting portion 730 and a second mounting portion 740. One end of the first support rod 710 and the second support rod 720 may be connected to the first mounting portion 730, and the other end of the first support rod 710 and the second support rod 720 may be connected to the second mounting portion 740. In the embodiment of the present application, the elastic bracket 700 is an integrally molded structure. That is, the first support rod 710, the second support rod 720, the first mounting portion 730 and the second mounting portion 740 are an integrally molded structure. The integral molding can make the elastic bracket 700 structurally stable, the components reliably connected, and the production and manufacturing simple and convenient. In some embodiments, such as Figure 1 As shown, the first mounting portion 730 and the second mounting portion 740 of the elastic bracket 700 can be fixedly connected to the second connecting member 300. That is, both ends of the first support rod 710 and the second support rod 720 are fixed to the second connecting member 300. The first support rod 710 of the elastic bracket 700 can abut against the connection between the first inner clamp arm 120 and the first outer clamp arm 140; the second support rod 720 of the elastic bracket 700 can abut against the connection between the second inner clamp arm 130 and the second outer clamp arm 150. For example, Figure 1 As shown, the first support rod 710 can be abutted between the first inner clamp arm 120 and the first outer clamp arm 140 from the inside, and the second support rod 720 can be abutted between the second inner clamp arm 130 and the second outer clamp arm 150 from the inside. In some embodiments, when the first support rod 710 or the second support rod 720 is abutted between the inner clamp arm and the outer clamp arm, the first support rod 710 or the second support rod 720 can be further fixedly connected to the connection between the inner clamp arm and the outer clamp arm by means of adhesive bonding, laser welding or winding wire connection. In some alternative embodiments, the first support rod 710 can be abutted against the outer side of the first outer clamp arm 140, and the second support rod 720 can be abutted against the outer side of the second outer clamp arm 150. For example, the middle part of the first support rod 710 can be fixedly connected to the outer side of the first outer clamp arm (such as adhesive bonding, laser welding or winding wire connection, etc.), and the second support rod 720 can be fixedly connected to the outer side of the second outer clamp arm 150. By providing the elastic support 700, the area of ​​the tissue clamping device for capturing tissue can be increased, and the elastic support 700 has a good supporting effect on the tissue, thereby improving the stability of the tissue clamping device. At the same time, the elastic support 100 has a good tightening effect, so the elastic force of the elastic support 700 can make the clamping force on the tissue greater after the first inner clamp arm 120 and the second inner clamp arm 130 are closed. In addition, the size of the elastic force provided by the elastic support 700 for the tissue clamping device can be adjusted according to the clamping requirements of different tissues or different patients' tissues (such as adjusting the width of the first support rod 710 and / or the second support rod 720), so that the tissue clamping device using the elastic support 700 can be suitable for different tissues or different patients.

[0147] In some embodiments, Fig.34As shown, the middle parts of the first support rod 710 and the second support rod 720 may respectively include a first arc segment 712, a second arc segment 714 and a third arc segment 716 connected in sequence; the protrusion direction of the second arc segment 714 is opposite to the protrusion direction of the first arc segment 712 and the third arc segment 716. The second arc segment 714 may protrude toward the second connecting member 300, and the first arc segment 712 and the third arc segment 716 may protrude in a direction away from the second connecting member 300. When the elastic bracket 700 is assembled with the clip body 100, the second arc segment 714 of the first support rod 710 and the second support rod 720 is located between the first inner clamp arm 120 and the first outer clamp arm 140, and between the second inner clamp arm 130 and the second outer clamp arm 150. With such a design, the first support rod 710 and the second support rod 720 can be better surrounded outside the support portion 110 to better cover the tissue.

[0148] In some embodiments, Fig.35 As shown, the first support rod 710 and the second support rod 720 may have a certain width. For example, the width of the first support rod 710 and the second support rod 720 may be greater than a set threshold. The set threshold may be 2 times, 3 times, or 4 times the thickness of the support rod (such as the first support rod 710 and the second support rod 720). In some embodiments, the width of the first support rod 710 and the second support rod 720 may be positively correlated with the elastic force provided by the elastic support 700 for the tissue clamping device. It can be understood that within a certain range, the wider the width of the first support rod 710 and the second support rod 720, the greater the elastic force provided by the elastic support 700 for the tissue clamping device, and the greater the clamping force of the tissue clamping device on the tissue. In some embodiments, the elastic support 700 of different widths may be selected according to the clamping requirements of different tissues or tissues of different patients. In some embodiments, the widths of each section of the first support rod 710 and the second support rod 720 may be different, so as to further adjust the elastic force provided by the elastic support 700 for the tissue clamping device.

[0149] In some embodiments, Fig.36 As shown, one end of the first support rod 710 and the second support rod 720 can be connected to the first mounting portion 730 through an S-rod bending structure 910; the other ends of the first support rod 710 and the second support rod 720 can be connected to the second mounting portion 740 through the S-rod bending structure 910. The S-rod bending structure 910 can include at least three straight rods 911 and two curved rods 912. The three straight rods 911 are parallel to each other and connected end to end through the two curved rods 912. For more details about the S-rod bending structure 910, see Figure 8-10 By providing an S-rod bending structure at the end of the support rod and connecting it to the mounting portion, the elastic bracket 700 (such as the end of the support rod) can be easily changed in shape during heat treatment.

[0150] In some embodiments, Fig.37 As shown, one end of the first support rod 710 and the second support rod 720 can be connected to the first mounting portion 730 through the first connecting portion 750; the other end of the first support rod 710 and the second support rod 720 can be connected to the second mounting portion 740 through the second connecting portion 760; through holes can be provided on the first connecting portion 750 and the second connecting portion 760. The number of the through holes can include one or more. The shape of the through hole can include but is not limited to a long strip, square, round, rectangular, etc. By providing through holes on the first connecting portion 750 and the second connecting portion 760, the elastic bracket 700 (such as the end of the support rod) can be easily changed in shape during heat treatment.

[0151] In some embodiments, the elastic support 700 may be an integrally formed structure made by cutting and heat treating a shape memory alloy tube. The shape memory alloy may be a nickel-titanium alloy or a cobalt-chromium alloy. Preferably, the elastic support 700 may be made of a superelastic metal (such as a nickel-titanium alloy). Fig.38 According to some embodiments of the present application Fig.33 A top view of the elastic support. Fig.38 It can be seen that Fig.37 The elastic support 700 in the embodiment is cut from a shape memory alloy tube. Figure 34-36 The elastic support 700 shown can also be cut and formed in one piece from a shape memory alloy tube. After the elastic support 700 is cut from the shape memory alloy tube, the elastic support 700 can be further subjected to heat treatment. Fig.39 According to some embodiments of the present application Fig.37 Schematic diagram of the structure of the elastic bracket after heat treatment. Fig.39 As shown, the first mounting portion 730 and the second mounting portion 740 after heat treatment and finalization can be relatively closed, so as to facilitate the installation of the elastic support 700 on the second connecting member 300. At the same time, the first support rod 710 and the second support rod 720 after heat treatment have prefabricated resilience. After the elastic support 700 is installed on the second connecting member 300 and assembled with the clamp body 100, when the first inner clamp arm 120 and the second inner clamp arm 130 clamp the tissue and close, the prefabricated resilience of the first support rod 710 and the second support rod 720 can make the first inner clamp arm 120 and the second inner clamp arm 130 further clamp the tissue, thereby making the tissue clamping device more stable.

[0152] Fig.40 is a schematic structural diagram of a first connecting member of a tissue clamping device according to some embodiments of the present application; Fig.41 Schematic diagram of the connection between the first connecting member and the clamp body of the tissue clamping device according to some embodiments of the present application. Figure 40-41As shown, the first connecting member 200 may be provided with a mounting bayonet 202, and one end of the supporting portion 110 of the clip body 100 (such as Fig.41 The upper end of the support portion 110 shown in the figure can be inserted into and fixed in the mounting bayonet 202. In addition, a through hole 204 can be provided on the first connector 200 for the brake rod 600 to pass through. A protrusion 206 can be provided on the side wall of the first connector 200 for the delivery connector 800 to engage. In some embodiments, after one end of the support portion 110 is inserted into the mounting bayonet 202, the support portion 110 can be fixedly connected to the first connector 200 by a pin. In some embodiments, after one end of the support portion 110 is inserted into the mounting bayonet 202, the support portion 110 can also be fixedly connected to the first connector 200 by gluing, welding, etc.

[0153] Fig.42 Schematic diagram of the connection structure between the tissue clamping device and the conveying assembly according to some embodiments of the present application. Figure 2 and Fig.42 As shown, the first connecting member 200 can be connected to the conveying connecting member 800 of the conveying assembly so that the tissue clamping device can be delivered to a predetermined position by the conveying assembly. After the tissue clamping device has clamped the tissue, the conveying connecting member 800 of the conveying assembly can be disengaged from the tissue clamping device so that the conveying assembly can be withdrawn, and the tissue clamping device will remain in the body.

[0154] like Fig.42 As shown, the conveying connection piece 800 may include a main body 810, a first connection piece 820 and a second connection piece 830. The connection between the first connection piece 820 and the second connection piece 830 and the main body 810 may have a prefabricated resilience, which can make the first connection piece 820 and the second connection piece 830 automatically open in a natural state. A fixed support rod 840 may also be provided in the middle of the first connection piece 820 and the second connection piece 830. The fixed support rod 840 is perpendicular to the first connection pieces 820 and 830, and a through hole is provided at one end of the fixed support rod 840 for the brake rod 600 to pass through. Figure 2 as well as Fig.42As shown, when the transport connector 800 is connected to the first connector 200 of the tissue clamping device, the first connector 820 and the second connector 830 are relatively closed and respectively engaged with the protrusion 206 on the first connector 200. At this time, the brake rod 600 can pass through the through hole on the fixed support rod 840 connected to the first connector 820 and the second connector 830, and the brake rod 600 will limit the first connector 820 and the second connector 830 from opening. When it is necessary to detach the transport assembly from the tissue clamping device, the connection between the brake rod 600 and the tissue clamping device can be released first and the brake rod 600 can be withdrawn, so that the brake rod 600 is detached from the through hole on the fixed support rod 840 connected to the first connector 820 and the second connector 830, so that the first connector 820 and the second connector 830 are automatically opened and detached from the engagement with the protrusion 206 on the first connector 200. In some embodiments, the transport connector 800 can be an integrally formed structure made of a shape memory alloy tube after cutting and heat treatment. Specifically, during the heat treatment process, the first connecting piece 820 and the second connecting piece 830 of the transport connector 800 can be bent relative to the main body 810 so that the connection between the first connecting piece 820 and the second connecting piece 830 and the main body 810 has a prefabricated resilience. In addition, the fixing support rod 840 can also be bent during the heat treatment process to be perpendicular to the first connecting piece 820 or the second connecting piece 830.

[0155] Fig.43 is a schematic structural diagram of a second connecting member of a tissue clamping device according to some embodiments of the present application; Fig.44 is a schematic diagram of the connection between the clip body and the second connecting member according to some embodiments of the present application; Fig.45 is a structural schematic diagram of a second connecting member of a tissue clamping device according to another embodiment of the present application; Fig.46 FIG. 1 is a schematic diagram of the connection between the clip body and the second connecting member according to another embodiment of the present application. Figure 43-46 As shown, a connection hole 302 (eg, a threaded hole) for detachably connecting with the brake rod 600 may be provided at the center of the second connection member 300. Figure 43-44 As shown, mounting holes 304 for mounting the first outer clamping arm 140, the second outer clamping arm 150, and the first mounting portion 730 and the second mounting portion 740 of the elastic bracket 700 may be provided around the connecting hole. Fig.44As shown, one end of the first outer clamp arm 140 (the lower end shown in the figure) can be inserted into one of the mounting holes 304 of the second connecting member 300 and fixedly connected to the second connecting member 300. In addition, one end of the second outer clamp arm 150 can also be inserted into another mounting hole 304 of the second connecting member 300 and fixedly connected to the second connecting member 300. The way in which one end of the first outer clamp arm 140 and one end of the second outer clamp arm 150 are fixedly connected to the second connecting member 300 may include gluing, welding, clamping, etc. from the inside or bottom end (the lower end shown in the figure) of the mounting hole 304. In some embodiments, as Figures 45-46 As shown, a protrusion 306 for mounting the first outer clamping arm 140, the second outer clamping arm 150 and the first mounting portion 730 and the second mounting portion 740 of the elastic bracket 700 may be provided on the side wall of the second connecting member 300. Fig.46 As shown, one end of the first outer clamp arm 140 (the lower end shown in the figure) can be clamped with one of the protrusions 306 of the second connecting member 300 and fixedly connected to the second connecting member. The way in which one end of the first outer clamp arm 140 is fixedly connected to the second connecting member 300 may include gluing, welding, etc. In some embodiments, after the four protrusions 306 on the side wall of the second connecting member 300 are clamped with the first outer clamp arm 140, the second outer clamp arm 150 and the first mounting portion 730 and the second mounting portion 740 of the elastic bracket 700, respectively, a fixing sleeve can be put on the outside of the second connecting member 300, so as to effectively prevent the components from being separated from the protrusions 306. Among them, the fixing sleeve can be fixedly connected to the second connecting member 300 by welding, gluing, etc. In some alternative embodiments, when the tissue clamping device includes a locking mechanism 500, a connecting hole fixedly connected to the locking tube can be set at the center of the second connecting member 300.

[0156] In some embodiments, the tissue clamping device can be controlled by a control handle, and the control handle can be connected to the tissue clamping device through a conveying assembly. Specifically, the control handle can include a brake rod control mechanism and a clip control mechanism. The brake rod control mechanism can be used to control the extension and rotation of the brake rod 600. The clip control mechanism can be used to control the opening and closing of the first clip 410 and the second clip 420 relative to the first inner clamp arm 120 and the second inner clamp arm 130, respectively.

[0157] In some embodiments, the method for using the tissue clamping device of the present application may include the following steps:

[0158] (1) delivering the tissue clamping device to a predetermined position through a delivery assembly;

[0159] (2) Controlling the second connecting member 300 to move relative to the first connecting member 200 by the brake rod 600, so that the first inner and outer arms 120 and the second inner clamping arm 130 are relatively opened to a suitable angle;

[0160] (3) controlling the first clamp 410 and the second clamp 420 to open and close relative to the first inner clamp arm 120 and the second inner clamp arm 130 respectively (e.g., by the first traction rope and the second traction rope), so that the tissue is clamped between the first clamp 410 and the first inner clamp arm 120 and between the second clamp 420 and the second inner clamp arm 130;

[0161] (4) controlling the second connecting member 300 to move relative to the first connecting member 200 so that the first inner clamping arm 120 and the second inner clamping arm 130 are relatively closed;

[0162] (5) Control the brake lever 600 and the conveying assembly to disengage from the tissue clamping device. If the tissue clamping device includes a locking mechanism 500, the locking fins 511 on the locking tube 510 will open outward to limit the relative opening of the first inner clamping arm 120 and the second inner clamping arm 130.

[0163] For example, when using a tissue clamping device to clamp the mitral valve to treat mitral regurgitation, the tissue clamping device can be delivered to the mitral valve through the left atrium, and then the second connecting member 300 is controlled to move relative to the first connecting member 200 through the brake rod 600, so that the first inner clamp arm 120 and the second inner clamp arm 130 of the clamp body 100 are opened to a suitable angle (such as 120°, 150°, 180°, etc.); and the first clamp 410 and the second clamp 420 are controlled to open relative to the first inner clamp arm 120 and the second inner clamp arm 130, respectively. The position of the tissue clamping device is further adjusted so that the first inner clamp arm 120 and the second inner clamp arm 130 are located on the left ventricle side of the mitral valve and the first inner clamp arm 120 and the second inner clamp arm 130 capture the mitral valve; then the first clamp 410 and the second clamp 420 are controlled to close relative to the first inner clamp arm 120 and the second inner clamp arm 130 respectively, so that the mitral valve can be clamped between the first inner clamp arm 120 and the first clamp 410 and between the second inner clamp arm 130 and the second clamp 420; then the first inner clamp arm 120 and the second inner clamp arm 130 of the clamp body 100 are controlled to close by the brake rod 600, and the operation of the tissue clamping device clamping the mitral valve is completed, and the mitral valve is changed from a large hole to two small holes. Then the brake rod 600 and the conveying assembly are controlled to disengage from the tissue clamping device, and the brake rod 600 and the conveying assembly can be withdrawn from the human body. In addition, when the tissue clamping device has a locking mechanism 500, when the brake rod 600 is disengaged from the locking tube 510, the locking wing 511 of the locking mechanism 500 automatically opens to limit the opening of the first inner clamp arm 120 and the second inner clamp arm 130 of the clamp body 100, thereby preventing the tissue clamping device from being disengaged from the mitral valve due to the impact of blood flow and other reasons.

[0164] The beneficial effects that the tissue clamping device disclosed in the present application may bring include but are not limited to: (1) one or more components of the tissue clamping device can be an integrally formed structure, which can make the structure of the tissue clamping device stable, the connection reliable, and the production and manufacturing simple and convenient; (2) through the bendable connection between the inner clamping arm and the support part, and the bendable connection between the inner clamping arm and the outer clamping arm, the inner clamping arm of the clamp body of the tissue clamping device can be flexibly closed or opened to better complete the capture and clamping of the tissue; (3) through the ingenious design of the bending structure, the relevant parts can be The parts are easy to deform by heat treatment, and a stable bending effect can be achieved between the parts; (4) by setting a barbed clamp, the tissue can be prevented from escaping from between the clamp and the inner clamp arm, thereby improving the stability of the tissue clamping device; (5) the locking mechanism can limit the opening of the inner clamp arm of the tissue clamping device after the tissue clamping device clamps the tissue, so that the tissue clamping device clamps the tissue more stably; (6) by setting an elastic bracket, not only can the tissue be more easily captured by the first inner clamp arm and the second inner clamp arm, but the tissue can also be protected and the stability of the tissue clamping device is improved. It should be noted that different embodiments may produce different beneficial effects. In different embodiments, the beneficial effects that may be produced may be any one or a combination of the above, or any other beneficial effects that may be obtained.

[0165] The above are only preferred embodiments of the present application and are not intended to limit the present application. Any modifications, equivalent substitutions and improvements made within the spirit and principles of the present application should be included in the protection scope of the present application.

Claims

1. A tissue clamping device, It is characterized in that It includes a clip body, a first connecting piece, a second connecting piece, a clip and a locking mechanism; The clip body comprises a support portion, a first inner clamp arm, a first outer clamp arm, a second inner clamp arm and a second outer clamp arm, one side of the support portion is bendably connected to the first inner clamp arm and the first outer clamp arm in sequence, and the other side of the support portion is bendably connected to the second inner clamp arm and the second outer clamp arm in sequence, and the clip body is an integrally formed structure; The clamp body is connected between the first connecting member and the second connecting member, and the relative movement of the first connecting member and the second connecting member can drive the first inner clamp arm and the second inner clamp arm to open or close relative to each other; The clip includes a first clip disposed on the first inner clip arm and a second clip disposed on the second inner clip arm, the first clip and the second clip can be opened and closed relative to the first inner clip arm and the second inner clip arm respectively, and enable the tissue to be clamped between the first clip and the first inner clip arm and between the second clip and the second inner clip arm; The locking mechanism comprises a locking tube and a locking piece; one end of the locking tube is fixedly connected to the second connecting piece, and a locking wing is provided on the outer wall of the locking tube; the locking piece is fixedly connected to the supporting part; the locking wing can limit the relative opening of the first inner clamp arm and the second inner clamp arm by limiting the movement of the locking piece; the locking tube and the locking wing are an integrally formed structure; The locking mechanism further comprises a sleeve, which can be sleeved outside the locking tube and retract the locking wing.

2. The tissue clamping device according to claim 1, It is characterized in that One end of the support portion is connected to the first connecting member, and one end of the first outer clamping arm and one end of the second outer clamping arm are respectively connected to the second connecting member.

3. The tissue clamping device according to claim 1, It is characterized in that One side of the support portion is connected to the first inner clamp arm via a first bending structure; the other side of the support portion is connected to the second inner clamp arm via a first bending structure; the first bending structure is an S-bar bending structure or a waist-slimming bending structure; The first inner clamp arm is connected to the first outer clamp arm via a second bending structure; the second inner clamp arm is connected to the second outer clamp arm via a second bending structure; the second bending structure is an S-rod bending structure or a waist-slimming bending structure.

4. The tissue clamping device according to claim 3, It is characterized in that The S-rod bending structure comprises at least three straight rod sections and two curved rod sections, wherein the three straight rod sections are parallel to each other and are connected end to end through the two curved rod sections.

5. The tissue clamping device according to claim 1, It is characterized in that The support portion is a grid structure; the grid structure includes diamond-shaped grids.

6. The tissue clamping device according to claim 1, It is characterized in that The clip body is an integrally formed structure made by cutting and heat treating a shape memory alloy tube.

7. The tissue clamping device according to claim 1, It is characterized in that The clip is a barbed clip, and the barbed clip includes a fixing portion, a clamping portion and barbs; One end of the fixing portion is connected to one end of the clamping portion via a bending portion; The other end of the clamping portion is provided with the barb.

8. The tissue clamping device according to claim 7, It is characterized in that The fixing portion, the clamping portion and the barb are an integrally formed structure.

9. The tissue clamping device according to claim 8, It is characterized in that The barbs include a plurality of barbs; wherein, At least one barb is connected to the other end of the clamping portion via an S-rod bending structure, and / or at least one barb is provided with a through hole.

10. The tissue clamping device according to claim 7, It is characterized in that The barb is detachably connected to the other end of the clamping portion; The other end of the clamping portion includes a clamping groove, and the barb includes a clamping ring, and the clamping ring can be clamped with the clamping groove.

11. The tissue clamping device according to claim 7, It is characterized in that The fixing part and the clamping part are an integrally formed structure made of shape memory alloy after cutting and heat treatment; After heat treatment and shaping, the fixing portion and the clamping portion form a certain angle, and the bending portion has a prefabricated resilience.

12. The tissue clamping device according to claim 7, It is characterized in that The first inner clamp arm and the second inner clamp arm are provided with through holes matched with the barbs.

13. The tissue clamping device according to claim 7, It is characterized in that The first inner clamp arm and the second inner clamp arm are provided with a clamping hole that cooperates with the fixing part of the barbed clamp, and the fixing part can be embedded in the clamping hole; the first inner clamp arm and the second inner clamp arm are also provided with a fixing groove, and the tissue clamping device also includes a fixing ring, which can be clamped with the fixing groove to limit the fixing part from being separated from the clamping hole.

14. The tissue clamping device according to claim 7, It is characterized in that The fixing portion and the clamping portion of the barbed clip are integrally formed with the clip body.

15. The tissue clamping device according to claim 1, It is characterized in that The tissue clamping device further comprises a brake rod, the brake rod is fixedly connected to the sleeve, and the brake rod can be detachably connected to the locking tube; When the brake rod is connected to the locking tube, the sleeve can retract the locking wing; when the brake rod is disengaged from the locking tube, the sleeve releases the effect on the locking wing, and the locking wing opens.

16. The tissue clamping device according to claim 1, It is characterized in that The locking fins include at least two pieces, and the at least two locking fins are arranged on the outer wall of the locking tube at different distances from the second connecting member; At least two locking wings can limit the opening of the clip body when the first inner clip arm and the second inner clip arm are relatively opened to different angles.

17. The tissue clamping device according to claim 1, It is characterized in that The tissue clamping device further comprises an elastic support, wherein the elastic support comprises a first support rod, a second support rod, a first mounting portion and a second mounting portion; One end of the first support rod and the second support rod is connected to the first mounting portion; the other end of the first support rod and the second support rod is connected to the second mounting portion; the first support rod, the second support rod, the first mounting portion and the second mounting portion are an integrally formed structure; The first mounting portion and the second mounting portion of the elastic bracket are fixedly connected to the second connecting member; the first support rod of the elastic bracket is supported at the connection between the first inner clamp arm and the first outer clamp arm; the second support rod of the elastic bracket is supported at the connection between the second inner clamp arm and the second outer clamp arm.

18. The tissue clamping device according to claim 17, It is characterized in that One end of the first support rod and the second support rod is connected to the first mounting portion via an S-rod bending structure; the other end of the first support rod and the second support rod is connected to the second mounting portion via an S-rod bending structure.

19. The tissue clamping device according to claim 17, It is characterized in that One end of the first support rod and the second support rod is connected to the first mounting portion via a first connecting portion; the other end of the first support rod and the second support rod is connected to the second mounting portion via a second connecting portion; and through holes are provided on the first connecting portion and the second connecting portion.

20. The tissue clamping device according to claim 1, It is characterized in that The support portion is a grid structure; the grid structure includes a circular grid.

21. The tissue clamping device according to claim 1, It is characterized in that The support portion is a grid structure; the grid structure includes a rectangular grid.

22. The tissue clamping device according to claim 1, It is characterized in that The support portion is a grid structure; the grid structure includes square grids.

23. The tissue clamping device according to claim 1, It is characterized in that The support portion is a grid structure; the grid structure includes a triangular grid.

24. The tissue clamping device according to claim 1, It is characterized in that The support portion is a grid structure; the grid structure includes a regular polygonal grid.

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