New reagent refrigeration mechanism

Abstract

The present invention discloses a novel reagent refrigeration mechanism, including a reagent bin, a rotating assembly, a driving assembly and a refrigeration assembly; the rotating assembly includes a main rotating member and a secondary rotating member; the main rotating member is used to drive a reagent box placed in the reagent bin to revolve under the drive of the driving assembly; the secondary rotating member is arranged on the main rotating member, and the secondary rotating member also rotates while revolving with the main rotating member, so as to drive at least one reagent bottle on the reagent box placed in the reagent bin to rotate relative to the reagent box through a stirring paddle arranged on the secondary rotating member. The present invention provides a refrigeration function for the reagent bin through a refrigeration assembly, and has a good refrigeration effect. The reagent box in the reagent bin is rotated through the rotating assembly, and the reagent bottle on the reagent box can also rotate relative to the reagent box, ensuring that the reagents therein are fully mixed, thereby realizing the functions of refrigeration, mixing and dispatching of the reagents.

Description

Technical Field

[0001] The invention relates to the field of biochemical detection equipment, and in particular to a novel reagent refrigeration mechanism. Background Art

[0002] In many automated detection instruments, such as chemiluminescence detectors, special reagent refrigeration devices are required to provide refrigeration, mixing and scheduling functions for reagents. That is, the reagents placed in the reagent compartment need to be refrigerated, and the reagents can be transferred to the designated location. At the same time, for some reagents (such as magnetic bead liquid, which includes buffer and magnetic beads, whether the magnetic beads and buffer are mixed evenly plays an important role in the detection results; since the magnetic bead liquid will sink to the bottom after being stationary for a long time, the magnetic bead liquid needs to be mixed before using it). The current reagent refrigeration device usually uses special refrigeration equipment to realize the refrigeration function, and for the mixing and scheduling functions, it is usually realized by using related mechanical mechanisms to drive the reagent box to rotate. However, the current reagent refrigeration device has problems such as insufficient mixing, poor refrigeration effect, and inconvenient placement of the reagent box, so a more reliable solution is needed now. Summary of the invention

[0003] The technical problem to be solved by the present invention is to provide a novel reagent refrigeration mechanism in view of the deficiencies in the above-mentioned prior art.

[0004] In order to solve the above technical problems, the technical solution adopted by the present invention is: a new reagent refrigeration mechanism, including a reagent chamber, a rotating component, a driving component and a refrigeration component;

[0005] The driving assembly is used to increase the driving force for the rotating assembly;

[0006] The rotating assembly is arranged inside the reagent compartment, and comprises a main rotating member and a secondary rotating member; the main rotating member is used to drive the reagent kit placed in the reagent compartment to revolve under the drive of the driving assembly; the secondary rotating member is arranged on the main rotating member, and the secondary rotating member revolves with the main rotating member while also rotating on its own, so as to drive at least one reagent bottle on the reagent kit placed in the reagent compartment to rotate relative to the reagent kit through a stirring paddle arranged on the secondary rotating member;

[0007] The refrigeration component is used to provide a refrigeration function for the reagent compartment.

[0008] Preferably, the reagent chamber comprises a bottom plate, a heat-insulating cover arranged on the bottom plate, and a cover plate arranged on the heat-insulating cover;

[0009] A guide groove is provided on the upper side wall of the heat-insulating cover, and a guide protrusion for inserting into the guide groove is provided at the bottom of the cover plate.

[0010] Preferably, a window is provided on the side of the heat preservation cover, and an anti-fog glass assembly is arranged on the window, and the anti-fog glass assembly includes a pressure plate connected to the side wall of the heat preservation cover, and a first glass sheet, a ring-shaped heating sheet and a second glass sheet stacked in sequence between the pressure plate and the side wall of the heat preservation cover.

[0011] Preferably, it further comprises a mounting plate, the reagent chamber is arranged on the mounting plate, and the refrigeration assembly is arranged at the bottom of the mounting plate;

[0012] The main rotating member comprises a large gear rotatably arranged on the bottom plate and a reagent code disk fixedly connected to the large gear, and a fixed gear is fixedly connected to the bottom plate; the large gear, the reagent code disk and the fixed gear are coaxially arranged;

[0013] A mounting hole is provided in the middle of the reagent code disk, and the fixed gear is fixedly connected to the bottom plate via a fixed shaft passing through the mounting hole.

[0014] Preferably, the secondary rotating member includes a plurality of pinions rotatably arranged in an annular array on the reagent code disk and meshing with the fixed gear, and the stirring paddle fixedly connected to the pinions, and the stirring paddle includes two stirring columns symmetrically arranged on the pinions.

[0015] Preferably, the driving assembly includes a motor arranged on the mounting plate, a driving gear connected to the output shaft of the motor, and a gear belt driving the driving gear and the large gear; when the driving gear drives the large gear and the reagent code disk to revolve through the gear belt, the small gear on the reagent code disk simultaneously rotates under the meshing action of the fixed gear.

[0016] Preferably, a support is provided on the fixed gear, a magnet is provided on the support, and an iron block for being attracted to the magnet is provided at the bottom of the cover plate.

[0017] Preferably, a plurality of positioning grooves are evenly spaced around the periphery of the reagent code disk, and a positioning baffle is also provided on the peripheral edge of the reagent code disk; and a first optical coupler and a second optical coupler are provided on the bottom plate for respectively cooperating with the positioning grooves and the positioning baffle.

[0018] Preferably, a plurality of mounting blocks are arranged in a circular array on the bottom plate, and a mounting groove for placing the reagent kit is formed between every two mounting blocks;

[0019] Two mounting blocks are symmetrically arranged on two inner walls at the bottom of the inner opening of the mounting groove, and limiting slots are arranged on the inner walls on both sides of the middle part of the mounting groove.

[0020] Preferably, a stirring plate is connected to the bottom of the reagent bottle rotatably arranged on the reagent kit, and after the reagent kit is arranged in the mounting groove, the two stirring columns are respectively arranged on both sides of the stirring plate, and when the two stirring columns rotate, the reagent bottle can be driven to rotate in the reagent kit through the stirring plate;

[0021] The upper outer walls of the reagent kit are symmetrically provided with protrusions, and the bottom outer walls of the reagent kit are symmetrically provided with two fixed slots. After the reagent kit is set in the installation slot, the installation card block is set in the fixed slot, and the protrusion is set in the fixed slot.

[0022] The beneficial effects of the present invention are as follows: the novel reagent refrigeration mechanism of the present invention provides a refrigeration function for the reagent compartment through a refrigeration component, and has a good refrigeration effect. The reagent box in the reagent compartment is rotated by the rotating component, and the reagent bottle on the reagent box can also rotate relative to the reagent box, ensuring that the reagents therein are fully mixed, thereby realizing the functions of refrigeration, mixing and dispatching of the reagents;

[0023] The present invention can prevent water mist from being generated on the window glass by providing an anti-fog glass component, thereby avoiding affecting the code scanning function;

[0024] The present invention can facilitate the closing of the cover plate and ensure that the cover plate is closed in place by arranging a guide mechanism and a magnetic mechanism on the cover plate and the heat preservation cover;

[0025] The reagent kit of the present invention can be stably mounted on the reagent code disk to realize the scheduling and mixing functions, and the reagent kit is convenient to take and put. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] Figure 1 It is a structural schematic diagram of the novel reagent refrigeration mechanism of the present invention;

[0027] Figure 2 This is a schematic diagram of the structure of the novel reagent refrigeration mechanism of the present invention after removing the heat insulation cotton;

[0028] Figure 3 It is a schematic cross-sectional structure diagram of the anti-fog glass assembly of the present invention in the thickness direction;

[0029] Figure 4 It is a schematic diagram of the internal structure of the novel reagent refrigeration mechanism of the present invention;

[0030] Figure 5 A schematic structural diagram of the interior of the novel reagent refrigeration mechanism of the present invention from another perspective;

[0031] Figure 6 It is a schematic diagram of the structure of the rotating assembly and the driving assembly of the present invention;

[0032] Figure 7It is a structural schematic diagram of the cover plate of the present invention;

[0033] Figure 8 It is a structural schematic diagram of the heat preservation cover of the present invention;

[0034] Fig. 9 It is a cross-sectional structural schematic diagram of the novel reagent refrigeration mechanism of the present invention;

[0035] Fig.10 It is a schematic diagram of the structure of the kit of the present invention;

[0036] Fig.11 It is a schematic structural diagram of the bottom of the kit of the present invention;

[0037] Fig.12 It is a schematic diagram of the cross-sectional structure of the kit of the present invention.

[0038] Description of reference numerals:

[0039] 1—reagent compartment; 10—bottom plate; 11—insulation cover; 12—cover plate; 13—insulation cotton; 14—guide groove; 15—guide convex block; 16—sealing ring; 17—window; 18—anti-fog glass assembly; 19—barcode gun; 100—first optical coupler; 101—second optical coupler; 120—iron block; 121—annular flange; 180—pressing plate; 181—first glass sheet; 182—annular heating sheet; 183—second glass sheet;

[0040] 2—main rotating member; 20—large gear; 21—reagent code disk; 22—fixed gear; 23—pillar; 24—magnet; 210—positioning groove; 211—positioning baffle; 212—mounting block; 213—mounting slot; 214—mounting card block; 215—limiting card slot;

[0041] 3—secondary rotating part; 30—pinion gear; 31—stirring paddle; 32—stirring column;

[0042] 4—driving assembly; 40—motor; 41—driving gear; 42—gear belt;

[0043] 5—Refrigeration components;

[0044] 6—Mounting plate;

[0045] 7—reagent box; 70—reagent bottle; 71—stirring sheet; 72—protrusion; 73—fixing slot. DETAILED DESCRIPTION

[0046] The present invention is further described in detail below in conjunction with embodiments so that those skilled in the art can implement the invention with reference to the description.

[0047] It should be understood that the terms such as “having”, “including” and “comprising” used herein do not exclude the existence or addition of one or more other elements or combinations thereof.

[0048] like Figure 1-12 As shown, a novel reagent refrigeration mechanism of this embodiment includes a reagent compartment 1, a rotating assembly, a driving assembly 4 and a refrigeration assembly 5;

[0049] The driving assembly 4 is used to increase the driving force for the rotating assembly;

[0050] The rotating assembly is arranged inside the reagent chamber 1, and includes a main rotating member 2 and a secondary rotating member 3; the main rotating member 2 is used to drive the reagent chamber 7 placed in the reagent chamber 1 to revolve under the drive of the driving assembly 4; the secondary rotating member 3 is arranged on the main rotating member 2, and the secondary rotating member 3 revolves with the main rotating member 2 while also rotating on its own, so as to drive at least one reagent bottle 70 on the reagent chamber 7 placed in the reagent chamber 1 to rotate relative to the reagent chamber 7 through the stirring paddle 31 arranged on the secondary rotating member 3;

[0051] The refrigeration component 5 is used to provide a refrigeration function for the reagent chamber 1. Conventional products can be used for the refrigeration component 5. In one embodiment, the refrigeration component 5 includes a Peltier and a fan. A heat conduction component is arranged between the Peltier and the reagent chamber 1. The reagent chamber 1 is cooled by the cold end of the Peltier, and the hot end of the Peltier is quickly cooled by the fan.

[0052] The novel reagent refrigeration mechanism of the present invention can be mainly used in automated detection equipment that needs to provide refrigeration, mixing and scheduling functions for reagents, such as chemiluminescence detectors. After a number of reagent kits 7 storing reagents (the reagent kits 7 are provided with at least one reagent bottle 70 that can rotate freely relative to the reagent kits 7) are placed in the reagent refrigeration mechanism, refrigeration is achieved through the refrigeration component 5; the main rotating part 2 drives the number of reagent kits 7 to rotate, and the reagent kits 7 are rotated to the specified position to achieve scheduling; the secondary rotating part 3 drives the reagent bottle 70 to rotate to achieve the mixing function.

[0053] Specifically, in one embodiment, the reagent chamber 1 includes a bottom plate 10, a heat preservation cover 11 arranged on the bottom plate 10, and a cover plate 12 arranged on the heat preservation cover 11; a guide groove 14 is provided on the upper side wall of the heat preservation cover 11, and a guide protrusion 15 for inserting into the guide groove 14 is provided at the bottom of the cover plate 12. An annular flange 121 is also provided at the bottom of the cover plate 12. When the cover plate 12 is covered on the heat preservation cover 11, the guide protrusion 15 is inserted into the guide groove 14 to achieve guidance, so that the cover plate 12 can be smoothly covered on the heat preservation cover 11; the annular flange 121 is located on the inner side of the opening of the upper part of the heat preservation cover 11, which can improve the sealing effect. Further, an annular groove is provided between the bottom of the cover plate 12 and the heat preservation cover 11, and a sealing ring 16 is provided in the annular groove. Further, a heat preservation cotton 13 is provided on the outside of the heat preservation cover 11 to improve the heat insulation effect and ensure a good refrigeration effect.

[0054] Among them, a window 17 is provided on the side of the heat preservation cover 11, and an anti-fog glass assembly 18 is arranged on the window 17. A barcode gun 19 is arranged on the side of the window 17, and the barcode on the side of the reagent box 7 is scanned by the barcode gun 19 to realize the scanning function, so as to detect and record the reagent box 7 in the reagent compartment 1. In a preferred embodiment, the anti-fog glass assembly 18 includes a pressing plate 180 connected to the side wall of the heat preservation cover 11, and a first glass sheet 181, an annular heating sheet 182 and a second glass sheet 183 stacked in sequence between the pressing plate 180 and the side wall of the heat preservation cover 11. Insulation cotton 13 is arranged between the first glass sheet 181 and the pressing plate 180, and between the second glass sheet 183 and the side wall of the heat preservation cover 11. Since the internal temperature of the heat preservation cover 11 is lower than that of the outside world, conventional single-layer glass is used, and the external air is easy to form condensed water on the glass, causing fog on the glass, which will affect the scanning of the reagent box 7. In this embodiment, a flexible heating sheet is selected as the annular heating sheet 182, and the first glass sheet 181 and the second glass sheet 183 are heated by the flexible heating sheet, so that there is basically no temperature difference between the first glass sheet 181 in contact with the external air and the second glass sheet 183 in contact with the first glass sheet 181, so that the external air will not generate condensation water on the first glass sheet 181, thereby achieving an anti-fog function.

[0055] The novel reagent refrigeration mechanism of the present invention further comprises a mounting plate 6 , the reagent chamber 1 is arranged on the mounting plate 6 , and the refrigeration assembly 5 is arranged at the bottom of the mounting plate 6 .

[0056] In one embodiment, the main rotating member 2 includes a large gear 20 rotatably arranged on the bottom plate 10, a reagent code disk 21 fixedly connected to the large gear 20, and a fixed gear 22 fixedly connected to the bottom plate 10; the large gear 20, the reagent code disk 21 and the fixed gear 22 are coaxially arranged; a mounting hole (not shown in the figure) is opened in the middle of the reagent code disk 21, and the fixed gear 22 is fixedly connected to the bottom plate 10 through a fixed shaft passing through the mounting hole. The secondary rotating member 3 includes a plurality of small gears 30 rotatably arranged on the reagent code disk 21 in an annular array and meshing with the fixed gear 22, and a stirring paddle 31 fixedly connected to the small gear 30, and the stirring paddle 31 includes two stirring columns 32 symmetrically arranged on the small gear 30.

[0057] Furthermore, the driving assembly 4 includes a motor 40 arranged on the mounting plate 6, a driving gear 41 connected to the output shaft of the motor 40, and a gear belt 42 driving the driving gear 41 and the large gear 20; when the driving gear 41 drives the large gear 20 and the reagent code disk 21 to revolve through the gear belt 42, the small gear 30 on the reagent code disk 21 simultaneously rotates under the meshing action of the fixed gear 22.

[0058] Further, a support 23 is provided on the fixed gear 22, a magnet 24 is provided on the support 23, and an iron block 120 for engaging with the magnet 24 is provided at the bottom of the cover 12. After the cover 12 is covered on the heat preservation cover 11, the magnet 24 is attracted to the iron block 120 to ensure that the cover 12 is covered in place and to improve the covering stability. In a further embodiment, a conventional position switch can also be provided on the heat preservation cover 11 to detect whether the cover 12 is covered.

[0059] Furthermore, a plurality of positioning grooves 210 are evenly spaced on the outer periphery of the reagent code disk 21, and a positioning baffle 211 is also provided on the outer periphery of the reagent code disk 21; a first optical coupler 100 and a second optical coupler 101 are provided on the bottom plate 10 for respectively cooperating with the positioning grooves 210 and the positioning baffle 211. The number of the positioning grooves 210 corresponds to the number of the pinion gears 30. Among them, one optical coupler is used as an origin detection optical coupler, and the other is used as a position detection optical coupler. For example, in this embodiment, both optical couplers are reflective optical couplers, and the first optical coupler 100 is used as an origin detection optical coupler. When the reagent code disk 21 rotates until the positioning baffle 211 reaches above the first optical coupler 100, a signal is triggered, indicating that the reagent code disk 21 has reached the origin; the second optical coupler 101 is used as a position detection optical coupler. When the reagent code disk 21 rotates until one of the positioning grooves 210 reaches above the second optical coupler 101, it indicates that the pinion 30 corresponding to the position (that is, the reagent reagent 7 thereon) has reached the working position. When the next reagent reagent 7 reaches the position, a signal is triggered again, thereby determining how much the reagent disk has rotated to achieve the positioning function. A group of mutually corresponding positioning grooves 210 and pinion 30 are on the same radius line.

[0060] In a further preferred embodiment, a plurality of mounting blocks 212 are arranged in a circular array on the bottom plate 10, and a mounting groove 213 for placing the reagent box 7 is formed between every two mounting blocks 212; two mounting blocks 214 are symmetrically arranged on the two inner walls at the bottom of the inner opening of the mounting groove 213, and a limited position groove 215 is provided on the inner walls on both sides of the middle of the mounting groove 213. At least one rotatable reagent bottle 70 is arranged on the reagent box 7. In this embodiment, two reagent bottles 70 are arranged on the reagent box 7, one of which is fixed and the other is rotatable, and a stirring piece 71 is connected to the bottom of the rotatable reagent bottle 70 on the reagent box 7; the rotatable reagent bottle 70 stores reagents that need to be mixed, such as magnetic bead liquid (the magnetic bead liquid includes buffer solution and magnetic beads, and whether the magnetic beads and buffer solution are mixed evenly plays an important role in the test results. Since the magnetic bead liquid will sink to the bottom after being stationary for a long time, the magnetic bead liquid needs to be mixed before using it). After the reagent box 7 is set in the installation groove 213, the two stirring columns 32 are respectively set on both sides of the stirring plate 71. When the two stirring columns 32 rotate, the stirring plate 71 can drive the reagent bottle 70 to rotate in the reagent box 7 to ensure that the reagent can be fully mixed;

[0061] The upper two side outer walls of the reagent box 7 are symmetrically provided with protrusions 72, and the bottom two side outer walls of the reagent box 7 are symmetrically provided with two fixed card slots 73. After the reagent box 7 is set in the installation slot 213, the installation card block 214 is clamped in the fixed card slot 73, and the protrusion 72 is clamped in the fixed card slot 73. The reagent box 7 can be stably installed on the reagent code disk 21, and it is convenient to take and put.

[0062] The working principle of the new reagent refrigeration mechanism is:

[0063] The reagent kit 7 is loaded into the mounting groove 213 on the reagent code disk 21 from top to bottom. The protrusion 72 on the reagent kit 7 passes over the inner wall of the upper part of the fixed groove 73 and is inserted into the fixed groove 73, thereby limiting the up and down movement of the reagent kit 7; the mounting block 214 on the inner side of the mounting groove 213 is inserted into the limit groove 215 to limit the horizontal movement of the reagent kit 7, so that the reagent kit 7 is stably arranged in the mounting groove 213, and the stirring piece 71 at the bottom of the rotatable reagent bottle 70 is just between the two stirring columns 32 on the pinion 30;

[0064] The driving gear 41 drives the large gear 20 and the reagent code disk 21 to revolve through the gear belt 42 to transfer the reagent kit 7 on the reagent code disk 21 to the specified position. When the reagent kit 7 moves to the window 17, the scanning gun scans the reagent kit 7; the small gear 30 on the reagent code disk 21 revolves together with the reagent code disk 21. Since the small gear 30 is meshed with the fixed gear 22, and the fixed gear 22 is fixed, the small gear 30 can rotate, so that the small gear 30 rotates while revolving; the two stirring columns 32 on the small gear 30 rotate, and by cooperating with the stirring plate 71 at the bottom of the reagent bottle 70, the reagent bottle 70 is driven to rotate in the reagent kit 7 to mix the reagent in the reagent bottle 70.

[0065] Although the embodiments of the present invention have been disclosed as above, they are not limited to the applications listed in the specification and the implementation modes. They can be fully applied to various fields suitable for the present invention. For those familiar with the art, additional modifications can be easily implemented. Therefore, without departing from the general concept defined by the claims and the scope of equivalents, the present invention is not limited to specific details.

Claims

1. A new type of reagent refrigeration mechanism, It is characterized in that It includes a reagent chamber, a rotating assembly, a driving assembly and a refrigeration assembly; The driving assembly is used to increase the driving force for the rotating assembly; The rotating assembly is arranged inside the reagent compartment, and comprises a main rotating member and a secondary rotating member; the main rotating member is used to drive the reagent kit placed in the reagent compartment to revolve under the drive of the driving assembly; the secondary rotating member is arranged on the main rotating member, and the secondary rotating member revolves with the main rotating member while also rotating on its own, so as to drive at least one reagent bottle on the reagent kit placed in the reagent compartment to rotate relative to the reagent kit through a stirring paddle arranged on the secondary rotating member; The refrigeration component is used to provide a refrigeration function for the reagent compartment; The reagent compartment comprises a bottom plate, a heat preservation cover arranged on the bottom plate, and a cover plate arranged on the heat preservation cover; A guide groove is provided on the upper side wall of the heat preservation cover, and a guide protrusion for inserting into the guide groove is provided at the bottom of the cover plate; A window is provided on the side of the heat preservation cover, and an anti-fog glass assembly is provided on the window, wherein the anti-fog glass assembly comprises a pressing plate connected to the side wall of the heat preservation cover, and a first glass sheet, an annular heating sheet, and a second glass sheet which are sequentially stacked between the pressing plate and the side wall of the heat preservation cover; The novel reagent refrigeration mechanism further comprises a mounting plate, the reagent chamber is arranged on the mounting plate, and the refrigeration assembly is arranged at the bottom of the mounting plate; The main rotating member comprises a large gear rotatably arranged on the bottom plate and a reagent code disk fixedly connected to the large gear, and a fixed gear is fixedly connected to the bottom plate; the large gear, the reagent code disk and the fixed gear are coaxially arranged; A mounting hole is provided in the middle of the reagent code disk, and the fixed gear is fixedly connected to the bottom plate via a fixed shaft passing through the mounting hole; The secondary rotating member includes a plurality of pinions rotatably arranged in an annular array on the reagent code disk and meshing with the fixed gear, and the stirring paddle fixedly connected to the pinions, and the stirring paddle includes two stirring columns symmetrically arranged on the pinions; The driving assembly includes a motor disposed on the mounting plate, a driving gear connected to an output shaft of the motor, and a gear belt drivingly connecting the driving gear and a large gear; When the driving gear drives the large gear and the reagent code disk to revolve through the gear belt, the small gear on the reagent code disk simultaneously rotates under the meshing action of the fixed gear; The fixed gear is provided with a support column, the support column is provided with a magnet, and the bottom of the cover plate is provided with an iron block for attracting the magnet; The outer periphery of the reagent code disk is evenly spaced with a plurality of positioning grooves, and the outer peripheral edge of the reagent code disk is also provided with a positioning baffle; the bottom plate is provided with a first optical coupler and a second optical coupler for respectively cooperating with the positioning groove and the positioning baffle; A plurality of mounting blocks are arranged in a circular array on the bottom plate, and a mounting groove for placing the reagent kit is formed between every two mounting blocks; On the bottom two inner walls at the inner opening of the installation groove, two installation blocks are symmetrically arranged, and limiting card slots are opened on the two inner walls on both sides in the middle of the installation groove; At the bottom of the reagent bottle rotatably arranged on the reagent kit, a stirring piece is connected. After the reagent kit is arranged in the installation groove, the two stirring columns are respectively arranged on both sides of the stirring piece. When the two stirring columns rotate, the reagent bottle can be driven to rotate in the reagent kit through the stirring piece; On the outer walls on both sides of the upper part of the reagent kit, protrusions are symmetrically arranged. On the outer walls on both sides of the bottom of the reagent kit, two fixed card slots are symmetrically arranged. After the reagent kit is arranged in the installation groove, the installation blocks are clamped in the fixed card slots, and the protrusions are clamped in the fixed card slots.

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