CIP and SIP Devices and Processes for High-Pressure Microfluidization Homogenizers

Abstract

The present invention discloses a high-pressure microfluidic homogenizer CIP and SIP device and process in the field of high-pressure homogenizers, including a hydraulic cylinder and a plunger pump connected to the hydraulic cylinder. It also includes a first cleaning water inlet, a second steam inlet, a third material outlet, a fourth drain outlet, a fifth material inlet, and a sixth clean compressed air inlet. The other end of valve eleven converges with the other end of valve one and is connected in parallel through a pipeline to one end of valve twelve, check valve one, and valve nine. The other end of valve twelve is connected in parallel through a pipeline to one end of valve two and valve thirteen. The other end of valve two is connected to the plunger pump inlet through a pipeline. The other ends of check valve three and valve four converge and are respectively connected through a pipeline to safety valve one and the other two ends of a three-way valve. One end of a fixed geometry interaction chamber is connected to one end of a fixed geometry interaction chamber jacket through check valve four, effectively solving the problems faced by the current high-pressure microfluidic homogenizer industry, reducing equipment and operation costs, improving production efficiency, and ensuring the sterilization effect.

Description

Technical Field

[0001] The present invention relates to the technical field of high-pressure homogenizers, and specifically to a CIP and SIP device and process for a high-pressure microfluidic jet homogenizer. Background Art

[0002] With the rapid improvement of nanotechnology and the level of biomedical research and development, currently in the biomedical, cosmetics and other industries, nano-level pharmaceutical and cosmetic products are constantly emerging. Especially in the biomedical industry, complex injection products represented by nano-level liposomes, nanoparticles, nanoemulsions, nanosuspensions and other dosage forms are constantly emerging, and these products are increasingly showing superiority in the fields of anti-cancer drugs and targeted drug therapy. In the cosmetics field, there are also more and more cosmetics using nanoemulsions and nanoliposomes as carriers for encapsulating active ingredients. Through the application of transdermal technology and the technology of encapsulating active ingredients, these cosmetics effectively transport the active ingredients of cosmetics into the cells and the basal layer of the muscle, greatly improving the efficacy of cosmetics. The application of nanotechnology represented by complex injections and nano-level cosmetics fully reflects the benefits brought by technological development to mankind. At the same time, the development of these industries and the requirements of human pharmaceutical industry regulations (the typical representative is GMP) urgently require the upgrading of nano-pharmaceutical preparation equipment to meet the needs of pharmaceutical safety and human health protection. However, the core equipment of nano-level pharmaceutical homogenizers represented by high-pressure microfluidic jet homogenizers still has deficiencies in meeting GMP regulations, especially in terms of CIP and SIP applications, and it cannot adapt to the development needs of the industry in terms of being fully efficient, easy to operate and automated.

[0003] Based on this, the present invention designs a CIP and SIP device and process for a high-pressure microfluidic jet homogenizer, aiming to provide a mature and advanced technology for the CIP and SIP, and automated applications of the high-pressure microfluidic jet homogenizer, making it more efficient, easy to operate and automated, so as to meet the development needs of the industry and solve the problems mentioned above. Summary of the Invention

[0004] The purpose of the present invention is to provide a CIP and SIP device and process for a high-pressure microfluidic jet homogenizer to solve the problems raised in the above background art.

[0005] To achieve the above object, the present invention provides the following technical solution: A CIP and SIP device for a high-pressure microfluidization homogenizer, comprising a hydraulic cylinder and a plunger pump connected to the hydraulic cylinder. A plunger pump jacket is welded to the outside of the plunger pump. It also includes a first cleaning water inlet, a second steam inlet, a third material outlet, a fourth drain outlet, a fifth material inlet, and a sixth clean compressed air inlet. The first cleaning water inlet is connected to one end of a valve eleven through a pipeline. The second steam inlet is connected to one end of a valve one through a pipeline. The other end of the valve eleven and the other end of the valve one converge, and are connected in parallel through a pipeline to one end of a valve twelve, a check valve one, and a valve nine. The other end of the valve twelve is connected in parallel through a pipeline to one end of a valve two and a valve thirteen. The other end of the valve two is connected to the plunger pump inlet through a pipeline. The other end of the valve thirteen is respectively connected to the plunger pump inlet and one end of a valve ten. The other end of the valve ten is connected to the plunger pump jacket inlet. The outlet of the plunger pump jacket and the outlet of the plunger pump are respectively connected to one end of a check valve three and a valve three. The other end of the valve three is respectively connected to a valve four and a steam trap one. A temperature probe one is installed at the inlet of the steam trap one. The other ends of the check valve three and the valve four converge, and are connected through a pipeline to one end of a safety valve one, a valve fifteen, and a valve fourteen. The other end of the valve fourteen is connected to a liquid sight glass one. The other end of the check valve one is successively connected to the plunger pump, a check valve two, and one end of a three-way valve. The other two ends of the three-way valve are respectively connected to one end of a check valve four through which one end of a fixed geometry interaction chamber is connected to one end of a fixed geometry interaction chamber jacket, and a check valve five is provided at the other end of the fixed geometry interaction chamber jacket. The other end of the fixed geometry interaction chamber is respectively connected to one end of a valve six and a valve sixteen. The other end of the valve sixteen is connected to the check valve five. The other end of the valve nine is successively connected to a closable cup and one end of a valve eight. The third material outlet is respectively connected to the other ends of the valve six and the valve eight through a pipeline and a valve seven. On the pipeline connected to the fourth drain outlet, the ends of a safety valve two, a steam trap two, a liquid sight glass two, a safety valve one, a valve fifteen, a liquid sight glass one, and a steam trap one are respectively connected. The bottom outlet of the fixed geometry interaction chamber jacket is respectively connected to one end of a valve five and a valve seventeen. The other end of the valve five is connected to the other end of the steam trap two. The other end of the valve seventeen is connected to the other end of the liquid sight glass two. The other end of the safety valve two is connected between the valve sixteen and the valve six. A temperature probe two is installed between the valve five and the steam trap two. A pipeline is provided on the closable cup and is connected to the fifth material inlet. The pipeline where the valve eleven is located is connected in parallel between a valve eighteen and a pipeline connected to the sixth clean compressed air inlet.

[0006] Preferably, it further includes the process of this CIP and SIP for the high-pressure microfluidization homogenizer. The specific steps are as follows:

[0007] S1: Material handling: The product material enters from Material Inlet Five. Open the cover plate of the closable cup to allow the material to enter the closable cup. Then, it passes through Valve Nine and Check Valve One, is sucked by the plunger pump, passes through Check Valve Two, and undergoes high-pressure micro-jet action in the fixed geometric interaction cavity. After that, it passes through Valve Six and Valve Eight, closes Valve Seven, and seals the feed port of the closable cup with a clamp cover plate to perform repeated high-pressure micro-jet action on the material. After the high-pressure micro-jet action is completed, close Valve Eight, open Valve Seven, and the material is discharged from Material Outlet Three;

[0008] S2: Cleaning of UCIP Dirty Pipe One. The cleaning water enters from Cleaning Water Inlet One, passes through Valve Eleven and Check Valve One, is sucked by the plunger pump, passes through Check Valve Two, adjusts the three-way valve to allow the cleaning water to pass through Check Valve Four and enter the jacket of the fixed geometric interaction cavity, passes through Valve Seventeen and Liquid Sight Glass Two, and then is discharged from Drain Port Four;

[0009] S3: Cleaning of UCIP Dirty Pipe Two. The cleaning water enters from Cleaning Water Inlet One, successively passes through Valve Eleven, Valve Nine, the closable cup, Valve Eight, Valve Six, Valve Sixteen and Check Valve Five, allowing the cleaning water to enter the jacket of the fixed geometric interaction cavity, passes through Valve Seventeen and Liquid Sight Glass Two, and then is discharged from Drain Port Four;

[0010] S4: Cleaning of the Diamond Fixed Geometric Interaction Cavity of UCIP Dirty Pipe Three. The cleaning water enters from Cleaning Water Inlet One, passes through Valve Eleven. One path passes through Check Valve One, is sucked by the plunger pump, passes through Check Valve Two, and enters the fixed geometric interaction cavity. The other path passes through Valve Nine, the closable cup, Valve Eight, Valve Six and converges with the cleaning water in the fixed geometric interaction cavity, and through Valve Sixteen and Check Valve Five, allows the cleaning water to enter the jacket of the fixed geometric interaction cavity, passes through Valve Seventeen and Liquid Sight Glass Two, and then is discharged from Drain Port Four;

[0011] S5: Cleaning of UCIP Plunger Seal. The cleaning water enters from Cleaning Water Inlet One, passes through Valve Eleven, then passes through Valve Twelve and Valve Thirteen, enters from the inlet of the plunger pump, and successively passes through Valve Fourteen and Liquid Sight Glass One from the outlet of the plunger pump, and then is discharged from Drain Port Four;

[0012] S6: Cleaning of UCIP Hydraulic Cylinder. The cleaning water enters from Cleaning Water Inlet One, passes through Valve Eleven, then passes through Valve Twelve and Valve Two, enters from the inlet of the hydraulic cylinder, and successively passes through Valve Three and Steam Trap One from the outlet of the hydraulic cylinder, and then is discharged from Drain Port Four;

[0013] S7: SIP preheating: Sterile steam enters from steam inlet two. Valve one is opened, and the sterile steam enters the first pipeline, successively passing through valve nine, the closable cup, valve eight, valve six, valve sixteen, check valve five, and the fixed geometry interaction chamber jacket to preheat the first pipeline. At the same time, it enters the second pipeline, successively passing through check valve one, being sucked by the plunger pump, and then passing through check valve two to enter the fixed geometry interaction chamber jacket to preheat the second pipeline. After converging with the first path, it passes through valve seventeen and liquid sight glass two, and then discharges from drain port four. At the same time, sterile steam enters the third pipeline, successively passing through valve twelve, valve thirteen, and valve ten, then entering from the inlet of the plunger pump jacket and exiting from the outlet of the plunger pump jacket, and passing through check valve three to preheat the third pipeline. At the same time, sterile steam enters the fourth pipeline, successively passing through valve twelve, valve two, the inlet of the plunger pump, the outlet of the plunger pump, valve three, and valve four to preheat the fourth pipeline. After converging with the third pipeline, it passes through valve fifteen, and then discharges from drain port four;

[0014] S8: SIP insulation at 121°C: Sterile steam enters from steam inlet two. Valve one is opened, and the sterile steam enters the first pipeline, successively passing through valve nine, the closable cup, valve eight, valve six, valve sixteen, check valve five, and the fixed geometry interaction chamber jacket to insulate the first pipeline. At the same time, it enters the second pipeline, successively passing through check valve one, being sucked by the plunger pump, and then passing through check valve two to enter the fixed geometry interaction chamber jacket to insulate the second pipeline. After converging with the first path, it passes through valve five. During the process, the generated condensate flows from the steam trap two to drain port four and is discharged. During the sterilization process, if the pipeline system pressure is higher than the set pressure, safety valve two will be opened for pressure relief to meet the set sterilization time and the temperature requirement of temperature probe two; At the same time, sterile steam enters the third pipeline, successively passing through valve twelve, valve thirteen, and valve ten, then entering from the inlet of the plunger pump jacket and exiting from the outlet of the plunger pump jacket, and passing through check valve three and valve four to insulate the third pipeline. At the same time, sterile steam enters the fourth pipeline, successively passing through valve twelve, valve two, the inlet of the plunger pump, the outlet of the plunger pump, and valve three to insulate the fourth pipeline. After converging with the third pipeline, the generated condensate is discharged from steam trap one, and the total condensate finally discharges from drain port four. During the sterilization process, if the pipeline system pressure is higher than the set pressure, safety valve one will be opened for pressure relief to meet the set sterilization time and the temperature requirement of temperature probe one;

[0015] S9: Post-cooling after SIP: The clean compressed air enters from the clean compressed air inlet six. Open valve eighteen, and the clean compressed air enters the first pipeline, successively passing through valve nine, the closable cup, valve eight, valve six, valve sixteen, check valve five, and the fixed geometry interaction cavity jacket to cool the first pipeline. At the same time, it enters the second pipeline, successively passing through check valve one, being sucked by the plunger pump, passing through check valve two, entering the fixed geometry interaction cavity jacket to cool the second pipeline, and after converging with the first path, passing through valve seventeen and liquid sight glass two, and then discharging from drain port four. At the same time, the clean compressed air enters the third pipeline, successively passing through valve twelve, valve thirteen, valve ten, then entering from the inlet of the plunger pump jacket, exiting from the outlet of the plunger pump jacket, and passing through check valve three to cool the third pipeline, passing through valve fifteen, and then discharging from drain port four;

[0016] S10: Nitrogen filling and pressure maintaining after SIP: Nitrogen enters from the clean compressed air inlet six. Open valve eighteen, and the nitrogen enters the first pipeline, successively passing through valve nine, the closable cup, valve eight, valve six, valve sixteen. Valve sixteen is in a closed state to maintain pressure in the first pipeline. At the same time, the nitrogen enters the second pipeline, successively passing through check valve one, being sucked by the plunger pump, passing through check valve two, entering the fixed geometry interaction cavity jacket, and then entering the pipeline where valve sixteen is located to maintain pressure in the second pipeline.

[0017] Compared with the prior art, the beneficial effects of the present invention are as follows:

[0018] First: This device is designed in the form of functional modularization and can be assembled according to customer needs. Different assembly forms can meet different functions, thus better meeting the production needs of more customers;

[0019] Second: The pipeline design of this device is streamlined. The original multi-group thin-diameter sewage discharge pipelines are simplified into a single large-diameter pipe, which is convenient for its maintenance and reduces the use cost;

[0020] Third: This device can realize the functions of cyclic homogenization, cyclic extrusion, and cyclic cleaning, which can simplify the process, facilitate operation, and has stronger market competitiveness;

[0021] The innovative structure of the present invention enables the system to have a faster preheating efficiency, changes the pipeline and device design for sterilization, enables the homogenizer system to be completely sterilized, eliminating the need for customers to perform secondary sterilization operations, reducing the operation difficulty, and improving the production efficiency; The innovation that meets manual CIP and SIP also provides an automated solution, making the operation of production enterprises simple and improving the operation efficiency. Brief Description of the Drawings

[0022] To more clearly illustrate the technical solutions of the embodiments of the present invention, the following will briefly introduce the drawings required for the description of the embodiments. Obviously, the drawings in the following description are only some embodiments of the present invention. For those of ordinary skill in the art, without creative efforts, other drawings can be obtained based on these drawings.

[0023] Figure 1 Structural schematic diagram of the present invention;

[0024] Figure 2 Material handling schematic diagram of the present invention;

[0025] Figure 3 Schematic diagram of the first cleaning of the dirty pipe of UCIP of the present invention;

[0026] Figure 4 Schematic diagram of the second cleaning of the dirty pipe of UCIP of the present invention;

[0027] Figure 5 Schematic diagram of the cleaning of the diamond-fixed geometric interaction cavity of the third dirty pipe of UCIP of the present invention;

[0028] Figure 6 Schematic diagram of the cleaning of the plunger seal of UCIP of the present invention;

[0029] Figure 7 Schematic diagram of the cleaning of the hydraulic cylinder of UCIP of the present invention;

[0030] Figure 8 Schematic diagram of the preheating of SIP of the present invention;

[0031] Figure 9 Schematic diagram of the 121°C heat preservation of SIP of the present invention;

[0032] Figure 10 Schematic diagram of the post-cooling of SIP of the present invention;

[0033] Figure 11 Schematic diagram of the post-nitrogen filling and pressure maintaining of SIP of the present invention.

[0034] In the drawings, the list of components represented by each reference numeral is as follows:

[0035] 1. Hydraulic cylinder; 2. Plunger pump; 3. Plunger pump jacket; 4. Fixed geometric interaction cavity; 5. Fixed geometric interaction cavity jacket; 6. Enclosable material cup; 7. Valve 1; 8. Valve 2; 9. Valve 3; 10. Valve 4; 11. Valve 5; 12. Valve 6; 13. Valve 7; 14. Valve 8; 15. Valve 9; 16. Valve 10; 17. Valve 11; 18. Valve 12; 19. Valve 13; 20. Valve 14; 21. Valve 15; 22. Valve 16; 23. Valve 17; 24. Check valve 1; 25. Check valve 2; 26. Check valve 3; 27. Check valve 4; 28. Check valve 5; 29. Three-way valve; 30. Safety valve 1; 31. Safety valve 2; 32. Steam trap 1; 33. Steam trap 2; 34. Liquid sight glass 1; 35. Liquid sight glass 2; 36. Temperature probe 1; 37. Temperature probe 2; 38. Valve 18. Detailed implementation manners

[0036] The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative efforts shall fall within the protection scope of the present invention.

[0037] Please refer to Figure 1, the present invention provides a technical solution: a CIP and SIP device for a high-pressure microfluidization homogenizer, including a hydraulic cylinder 1 and a plunger pump 2 connected to the hydraulic cylinder 1. A plunger pump jacket 3 is welded to the outside of the plunger pump 2. It also includes a first cleaning water inlet, a second steam inlet, a third material outlet, a fourth drain outlet, a fifth material inlet, and a sixth clean compressed air inlet. The first cleaning water inlet is connected to one end of a valve eleven 17 through a pipeline. The second steam inlet is connected to one end of a valve one 7 through a pipeline. The other end of the valve eleven 17 and the other end of the valve one 7 converge, and are connected in parallel through a pipeline to one end of a valve twelve 18, a check valve one 24, and a valve nine 15. The other end of the valve twelve 18 is connected in parallel through a pipeline to one end of a valve two 8 and a valve thirteen 19. The other end of the valve two 8 is connected to the inlet of the plunger pump 2 through a pipeline. The other end of the valve thirteen 19 is respectively connected to the inlet of the plunger pump 2 and one end of a valve ten 16. The other end of the valve ten 16 is connected to the inlet of the plunger pump jacket 3. The outlet of the plunger pump jacket 3 and the outlet of the plunger pump 2 are respectively connected to one end of a check valve three 26 and a valve three 9. The other end of the valve three 9 is respectively connected to a valve four 10 and a steam trap one 32. A temperature probe one 36 is installed at the inlet of the steam trap one 32. The other ends of the check valve three 26 and the valve four 10 converge, and are connected through a pipeline to one end of a safety valve one 30, a valve fifteen 21, and a valve fourteen 20. The other end of the valve fourteen 20 is connected to a liquid sight glass one 34. The other end of the check valve one 24 is successively connected to the plunger pump 2, a check valve two 25, and one end of a three-way valve 29. The other two ends of the three-way valve 29 are respectively connected to a check valve four 27 that connects one end of a fixed geometry interaction chamber 4 and one end of a fixed geometry interaction chamber jacket 5. The other end of the fixed geometry interaction chamber jacket 5 is provided with a connected check valve five 28. The other end of the fixed geometry interaction chamber 4 is respectively connected to one end of a valve six 12 and a valve sixteen 22. The other end of the valve sixteen 22 is connected to the check valve five 28. The other end of the valve nine 15 is successively connected to a closable cup 6 and one end of a valve eight 14. The third material outlet is respectively connected to the other ends of the valve six 12 and the valve eight 14 through a pipeline and a valve seven 13. One end of a safety valve two 31, a steam trap two 33, a liquid sight glass two 35, a safety valve one 30, a valve fifteen 21, a liquid sight glass one 34, and a steam trap one 32 are respectively connected to the pipeline connected to the fourth drain outlet. The bottom outlet of the fixed geometry interaction chamber jacket 5 is respectively connected to one end of a valve five 11 and a valve seventeen 23. The other end of the valve five 11 is connected to the other end of the steam trap two 33. The other end of the valve seventeen 23 is connected to the other end of the liquid sight glass two 35. The other end of the safety valve two 31 is connected between the valve sixteen 22 and the valve six 12. A temperature probe two 37 is installed between the valve five 11 and the steam trap two 33. A pipeline is provided on the closable cup 6 and connected to the fifth material inlet.The pipeline where the valve eleven 17 is located is in parallel with the valve eighteen 38 and the pipeline connected to the clean compressed air inlet six. Example 1

[0038] As Figure 2 shown, for material handling: The product material enters from the material inlet five. Open the cover plate of the closable cup 6 so that the material enters the closable cup 6. Then, it passes through the valve nine 15 and the one-way valve one 24. After being sucked by the plunger pump 2, it passes through the one-way valve two 25. After the high-pressure micro-jet action is completed in the fixed geometric interaction cavity 4, it passes through the valve six 12 and the valve eight 14. Close the valve seven 13, and use a clamp cover plate to seal the feed port of the closable cup 6 to perform repeated high-pressure micro-jet action on the material. After the high-pressure micro-jet action is completed, close the valve eight 14, open the valve seven 13, and the material is discharged from the material outlet three; Example 2

[0039] As Figure 3 shown, for the cleaning of the UCIP dirty pipe one, the cleaning water enters from the cleaning water inlet one, passes through the valve eleven 17, passes through the one-way valve one 24. After being sucked by the plunger pump 2, it passes through the one-way valve two 25. Adjust the three-way valve 29 so that the cleaning water passes through the one-way valve four 27 and enters the fixed geometric interaction cavity jacket 5. Then, it passes through the valve seventeen 23 and the liquid sight glass two 35, and then is discharged from the drain port four; Example 3

[0040] As Figure 4 shown, for the cleaning of the UCIP dirty pipe two, the cleaning water enters from the cleaning water inlet one, and successively passes through the valve eleven 17, the valve nine 15, the closable cup 6, the valve eight 14, the valve six 12, the valve sixteen 22 and the one-way valve five 28, so that the cleaning water enters the fixed geometric interaction cavity jacket 5. Then, it passes through the valve seventeen 23 and the liquid sight glass two 35, and then is discharged from the drain port four; Example 4

[0041] As Figure 5 shown, for the cleaning of the UCIP dirty pipe three diamond fixed geometric interaction cavity, the cleaning water enters from the cleaning water inlet one, passes through the valve eleven 17. One way passes through the one-way valve one 24. After being sucked by the plunger pump 2, it passes through the one-way valve two 25 and enters the fixed geometric interaction cavity 4. The other way passes through the valve nine 15, the closable cup 6, the valve eight 14, the valve six 12 and converges with the cleaning water in the fixed geometric interaction cavity 4, and passes through the valve sixteen 22 and the one-way valve five 28, so that the cleaning water enters the fixed geometric interaction cavity jacket 5. Then, it passes through the valve seventeen 23 and the liquid sight glass two 35, and then is discharged from the drain port four; Example 5

[0042] As Figure 6As shown, for the cleaning of the UCIP plunger seal, the cleaning water enters from the first cleaning water inlet, passes through Valve Eleven 17, then through Valve Twelve 18 and Valve Thirteen 19, enters from the inlet of the plunger pump 2, and successively passes through Valve Fourteen 20 and the first liquid sight glass 34 from the outlet of the plunger pump 2, and then discharges from the fourth drain port; Example 6

[0043] As Figure 7 shown, for the cleaning of the UCIP hydraulic cylinder 1, the cleaning water enters from the first cleaning water inlet, passes through Valve Eleven 17, then through Valve Twelve 18 and Valve Two 8, enters from the inlet of the hydraulic cylinder 1, and successively passes through Valve Three 9 and the first steam trap 32 from the outlet of the hydraulic cylinder 1, and then discharges from the fourth drain port; Example 7

[0044] As Figure 8 shown, for the SIP preheating: The sterile steam enters from the second steam inlet, opens Valve One 7, the sterile steam enters the first pipeline, successively passes through Valve Nine 15, the closable measuring cup 6, Valve Eight 14, Valve Six 12, Valve Sixteen 22, Check Valve Five 28 and the fixed geometry interaction chamber jacket 5 to preheat the first pipeline. At the same time, it enters the second pipeline, successively passes through Check Valve One 24, after being sucked by the plunger pump 2, passes through Check Valve Two 25, enters the fixed geometry interaction chamber jacket 5 for preheating the second pipeline, and after converging with the first path, passes through Valve Seventeen 23 and the second liquid sight glass 35, and then discharges from the fourth drain port. At the same time, the sterile steam enters the third pipeline, successively passes through Valve Twelve 18, Valve Thirteen 19, Valve Ten 16, then enters from the inlet of the plunger pump jacket 3, exits from the outlet of the plunger pump jacket 3, and passes through Check Valve Three 26 for preheating the third pipeline. At the same time, the sterile steam enters the fourth pipeline, successively passes through Valve Twelve 18, Valve Two 8, the inlet of the plunger pump 2, the outlet of the plunger pump 2, Valve Three 9 and Valve Four 10 for preheating the fourth pipeline, and after converging with the third pipeline, passes through Valve Fifteen 21, and then discharges from the fourth drain port; Example 8

[0045] As Figure 9As shown, SIP121℃ insulation: sterile steam enters from steam inlet 2, valve 1 7 is opened, sterile steam enters the first pipeline, passes through valve 9 15, closable material cup 6, valve 8 14, valve 6 12, valve 16 22, check valve 5 28 and fixed geometry interactive cavity jacket 5 in sequence to insulate the first pipeline, and enters the second pipeline at the same time, passes through check valve 1 24 in sequence, and after being sucked by plunger pump 2, passes through check valve 2 25, enters the fixed geometry interactive cavity jacket 5, and insulates the second pipeline. After intersecting with the first pipeline, it passes through valve 5 11. During the process, the condensed water generated flows from steam trap 2 33 to drain port 4 and is discharged. During the sterilization process, the pipeline system pressure is higher than the set pressure. pressure, the safety valve 2 31 will be opened to release the pressure to meet the set sterilization time and the temperature requirements of the temperature probe 2 37; at the same time, the sterile steam enters the third pipeline, passes through the valve 12 18, the valve 13 19, the valve 10 16 in sequence, and then enters from the inlet of the plunger pump jacket 3, and exits from the outlet of the plunger pump jacket 3, and passes through the one-way valve 3 26 and the valve 4 10 to insulate the third pipeline. At the same time, the sterile steam enters the fourth pipeline, passes through the valve 12 18, the valve 2 8, the inlet of the plunger pump 2, the outlet of the plunger pump 2 and the valve 3 9 in sequence to insulate the fourth pipeline, and after intersecting with the third pipeline, the condensed water generated in the process is discharged from the steam trap 1 32, and the total condensed water is finally discharged from the drain port 4. During the sterilization process, the pressure of the pipeline system is higher than the set pressure, and the safety valve 1 30 will be opened to release the pressure to meet the set sterilization time and the temperature requirements of the temperature probe 1 36; Example 9

[0046] like Figure 10 As shown, SIP post-cooling: clean compressed air enters from the clean compressed air inlet six, opens valve eighteen 38, and the clean compressed air enters the first pipeline, passes through valve nine 15, the closable material cup 6, valve eight 14, valve six 12, valve sixteen 22, check valve five 28 and fixed geometry interactive cavity jacket 5 in sequence to cool the first pipeline, and enters the second pipeline at the same time, passes through check valve one 24 in sequence, and after being sucked by the plunger pump 2, passes through check valve two 25, enters the fixed geometry interactive cavity jacket 5, and cools the second pipeline, and after intersecting with the first pipeline, passes through valve seventeen 23 and liquid sight glass two 35, and then is discharged from the drain port four, and at the same time, the clean compressed air enters the third pipeline, passes through valve twelve 18, valve thirteen 19, valve ten 16 in sequence, and then enters from the inlet of the plunger pump jacket 3, and exits from the outlet of the plunger pump jacket 3, passes through check valve three 26, cools the third pipeline, passes through valve fifteen 21, and then is discharged from the drain port four; Example 10

[0047] like Figure 11As shown in the figure, after SIP, nitrogen is filled to maintain pressure: Nitrogen enters from the clean compressed air inlet six, valve eighteen 38 is opened, and nitrogen enters the first pipeline, successively passing through valve nine 15, the closable material cup 6, valve eight 14, valve six 12, valve sixteen 22. Valve sixteen 22 is in a closed state to maintain the pressure of the first pipeline. At the same time, nitrogen enters the second pipeline, successively passing through check valve one 24. After being sucked by the plunger pump 2, it passes through check valve two 25 and enters the fixed geometric interaction cavity jacket 5, and then enters the pipeline where valve sixteen 22 is located to maintain the pressure of the second pipeline.

[0048] In the description of this specification, the description with reference to terms such as "one embodiment", "example", "specific example", etc. means that the specific features, structures, materials or characteristics described in connection with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the schematic representation of the above terms does not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in a suitable manner in any one or more embodiments or examples.

[0049] The preferred embodiments of the present invention disclosed above are only used to help explain the present invention. The preferred embodiments do not describe all the details in detail, nor do they limit the invention to the specific embodiments described. Obviously, many modifications and changes can be made according to the content of this specification. These embodiments are selected and specifically described in this specification to better explain the principle and practical application of the present invention, so that those skilled in the art can understand and utilize the present invention well. The present invention is only limited by the claims and their full scope and equivalents.

Claims

1. High-pressure microfluidization homogenizer CIP and SIP device, including a hydraulic cylinder (1) and a plunger pump (2) connected to the hydraulic cylinder (1). A plunger pump jacket (3) is welded to the outside of the plunger pump (2). It is characterized in that: It also includes a cleaning water inlet 1, a steam inlet 2, a material outlet 3, a drain outlet 4, a material inlet 5, and a clean compressed air inlet 6. The cleaning water inlet 1 is connected to one end of a valve eleven (17) through a pipeline. The steam inlet 2 is connected to one end of a valve one (7) through a pipeline. The other end of the valve eleven (17) and the other end of the valve one (7) converge, and are connected in parallel to one end of a valve twelve (18), a check valve one (24), and a valve nine (15) through a pipeline. The other end of the valve twelve (18) is connected in parallel to one end of a valve two (8) and a valve thirteen (19) through a pipeline. The other end of the valve two (8) is connected to the inlet of a plunger pump (2) through a pipeline. The other end of the valve thirteen (19) is respectively connected to the inlet of the plunger pump (2) and one end of a valve ten (16). The other end of the valve ten (16) is connected to the inlet of a plunger pump jacket (3). The outlet of the plunger pump jacket (3) and the outlet of the plunger pump (2) are respectively connected to one end of a check valve three (26) and a valve three (9). The other end of the valve three (9) is respectively connected to a valve four (10) and a steam trap one (32). A temperature probe one (36) is installed at the inlet of the steam trap one (32). The other ends of the check valve three (26) and the valve four (10) converge, and are connected to one end of a safety valve one (30), a valve fifteen (21), and a valve fourteen (20) through a pipeline. The other end of the valve fourteen (20) is connected to a liquid sight glass one (34). The other end of the check valve one (24) is successively connected to the plunger pump (2), a check valve two (25), and one end of a three-way valve (29). The other two ends of the three-way valve (29) are respectively connected to a check valve four (27) that connects one end of a fixed geometry interaction cavity (4) and one end of a fixed geometry interaction cavity jacket (5). The other end of the fixed geometry interaction cavity jacket (5) is provided with a connected check valve five (28). The other end of the fixed geometry interaction cavity (4) is respectively connected to one end of a valve six (12) and a valve sixteen (22). The other end of the valve sixteen (22) is connected to the check valve five (28). The other end of the valve nine (15) is successively connected to a closable material cup (6) and one end of a valve eight (14). The material outlet 3 is respectively connected to the other ends of the valve six (12) and the valve eight (14) through a pipeline and a valve seven (13). One ends of a safety valve two (31), a steam trap two (33), a liquid sight glass two (35), a safety valve one (30), a valve fifteen (21), a liquid sight glass one (34), and a steam trap one (32) are respectively connected to the pipeline connected to the drain outlet 4. The bottom outlet of the fixed geometry interaction cavity jacket (5) is respectively connected to one end of a valve five (11) and a valve seventeen (23). The other end of the valve five (11) is connected to the other end of the steam trap two (33). The other end of the valve seventeen (23) is connected to the other end of the liquid sight glass two (35). The other end of the safety valve two (31) is connected between the valve sixteen (22) and the valve six (12).A temperature probe two (37) is installed between the valve five (11) and the steam trap two (33). A pipeline is provided on the closable material cup (6) and is connected to the material inlet five. The pipeline where the valve eleven (17) is located is in parallel between the valve eighteen (38) connected to the clean compressed air inlet six and the pipeline.

2. A high-pressure microfluidization homogenizer CIP and SIP process It is characterized in that: Based on the high-pressure microfluidization homogenizer CIP and SIP device described in claim 1, the specific steps are as follows: S1: Material processing: The product material enters from the material inlet five. Open the cover plate of the closable material cup (6) so that the material enters the closable material cup (6). Then, after passing through valve nine (15) and check valve one (24), it is sucked by the plunger pump (2), passes through check valve two (25), and undergoes high-pressure microfluidization in the fixed geometric interaction chamber (4). After that, it passes through valve six (12) and valve eight (14). Close valve seven (13), and use a clamp cover to seal the feed port of the closable material cup (6). Conduct repeated high-pressure microfluidization of the material. After the high-pressure microfluidization is completed, close valve eight (14), open valve seven (13), and the material is discharged from the material outlet three; S2: UCIP dirty pipe one cleaning. The cleaning water enters from the cleaning water inlet one, passes through valve eleven (17), passes through check valve one (24), is sucked by the plunger pump (2), passes through check valve two (25), adjusts the three-way valve (29) so that the cleaning water passes through check valve four (27) and enters the fixed geometric interaction chamber jacket (5). After passing through valve seventeen (23) and liquid sight glass two (35), it is then discharged from the drain port four; S3: UCIP dirty pipe two cleaning. The cleaning water enters from the cleaning water inlet one, and successively passes through valve eleven (17), valve nine (15), the closable material cup (6), valve eight (14), valve six (12), valve sixteen (22) and check valve five (28), so that the cleaning water enters the fixed geometric interaction chamber jacket (5). After passing through valve seventeen (23) and liquid sight glass two (35), it is then discharged from the drain port four; S4: UCIP dirty pipe three diamond fixed geometric interaction chamber cleaning. The cleaning water enters from the cleaning water inlet one, passes through valve eleven (17). One path passes through check valve one (24), is sucked by the plunger pump (2), passes through check valve two (25), and enters the fixed geometric interaction chamber (4). The other path passes through valve nine (15), the closable material cup (6), valve eight (14), valve six (12) and converges with the cleaning water in the fixed geometric interaction chamber (4). And through valve sixteen (22) and check valve five (28), the cleaning water enters the fixed geometric interaction chamber jacket (5). After passing through valve seventeen (23) and liquid sight glass two (35), it is then discharged from the drain port four; S5: Cleaning of the UCIP plunger seal. The cleaning water enters from the first cleaning water inlet, passes through Valve Eleven (17), then through Valve Twelve (18) and Valve Thirteen (19), enters from the inlet of the plunger pump (2), and exits from the outlet of the plunger pump (2) successively through Valve Fourteen (20) and the first liquid sight glass (34), and then is discharged from the fourth drain port; S6: Cleaning of the UCIP hydraulic cylinder (1). The cleaning water enters from the first cleaning water inlet, passes through Valve Eleven (17), then through Valve Twelve (18) and Valve Two (8), enters from the inlet of the hydraulic cylinder (1), and exits from the outlet of the hydraulic cylinder (1) successively through Valve Three (9) and the first steam trap (32), and then is discharged from the fourth drain port; S7: SIP preheating: The sterile steam enters from the second steam inlet. Open Valve One (7), and the sterile steam enters the first pipeline, successively passing through Valve Nine (15), the closable cup (6), Valve Eight (14), Valve Six (12), Valve Sixteen (22), Check Valve Five (28) and the fixed geometry interaction chamber jacket (5) for preheating the first pipeline. At the same time, it enters the second pipeline, successively passing through Check Valve One (24). After being sucked by the plunger pump (2), it passes through Check Valve Two (25) and enters the fixed geometry interaction chamber jacket (5) for preheating the second pipeline. After converging with the first path, it passes through Valve Seventeen (23) and the second liquid sight glass (35), and then is discharged from the fourth drain port. At the same time, the sterile steam enters the third pipeline, successively passing through Valve Twelve (18), Valve Thirteen (19), Valve Ten (16), then enters from the inlet of the plunger pump jacket (3), exits from the outlet of the plunger pump jacket (3), and passes through Check Valve Three (26) for preheating the third pipeline. At the same time, the sterile steam enters the fourth pipeline, successively passing through Valve Twelve (18), Valve Two (8), the inlet of the plunger pump (2), the outlet of the plunger pump (2), Valve Three (9) and Valve Four (10) for preheating the fourth pipeline. After converging with the third pipeline, it passes through Valve Fifteen (21), and then is discharged from the fourth drain port; S8: SIP at 121 °C insulation: Sterile steam enters from the second steam inlet. Valve 1 (7) is opened, and sterile steam enters the first pipeline, successively passing through Valve 9 (15), the closable material cup (6), Valve 8 (14), Valve 6 (12), Valve 16 (22), Check Valve 5 (28), and the fixed geometry interaction chamber jacket (5) to conduct insulation for the first pipeline. Meanwhile, it enters the second pipeline, successively passing through Check Valve 1 (24), and after being sucked by the plunger pump (2), passing through Check Valve 2 (25), and entering the fixed geometry interaction chamber jacket (5) to conduct insulation for the second pipeline. After converging with the first path, it passes through Valve 5 (11). During this process, the generated condensed water flows from the second steam trap (33) to Drain Port 4 and is discharged. During the sterilization process, when the pipeline system pressure is higher than the set pressure, Safety Valve 2 (31) will be opened for pressure relief to meet the temperature requirements of the set sterilization time and Temperature Probe 2 (37). Meanwhile, sterile steam enters the third pipeline, successively passing through Valve 12 (18), Valve 13 (19), Valve 10 (16), then entering from the inlet of the plunger pump jacket (3), exiting from the outlet of the plunger pump jacket (3), and passing through Check Valve 3 (26) and Valve 4 (10) to conduct insulation for the third pipeline. Meanwhile, sterile steam enters the fourth pipeline, successively passing through Valve 12 (18), Valve 2 (8), the inlet of the plunger pump (2), the outlet of the plunger pump (2), and Valve 3 (9) to conduct insulation for the fourth pipeline. After converging with the third pipeline, the generated condensed water is discharged from the first steam trap (32). The total condensed water finally discharges from Drain Port 4. During the sterilization process, when the pipeline system pressure is higher than the set pressure, Safety Valve 1 (30) will be opened for pressure relief to meet the temperature requirements of the set sterilization time and Temperature Probe 1 (36). S9: Post - SIP cooling: Clean compressed air enters from the sixth clean compressed air inlet. Valve 18 (38) is opened, and clean compressed air enters the first pipeline, successively passing through Valve 9 (15), the closable material cup (6), Valve 8 (14), Valve 6 (12), Valve 16 (22), Check Valve 5 (28), and the fixed geometry interaction chamber jacket (5) to conduct cooling for the first pipeline. Meanwhile, it enters the second pipeline, successively passing through Check Valve 1 (24), and after being sucked by the plunger pump (2), passing through Check Valve 2 (25), and entering the fixed geometry interaction chamber jacket (5) to conduct cooling for the second pipeline. After converging with the first path, it passes through Valve 17 (23) and the second liquid sight glass (35), and then discharges from Drain Port 4. Meanwhile, clean compressed air enters the third pipeline, successively passing through Valve 12 (18), Valve 13 (19), Valve 10 (16), then entering from the inlet of the plunger pump jacket (3), exiting from the outlet of the plunger pump jacket (3), and passing through Check Valve 3 (26) to conduct cooling for the third pipeline. It passes through Valve 15 (21), and then discharges from Drain Port 4. S10: Post - charge nitrogen pressure - maintaining after SIP: Nitrogen enters from the clean compressed air inlet six. Open valve eighteen (38), and nitrogen enters the first pipeline, successively passing through valve nine (15), the closable material cup (6), valve eight (14), valve six (12), valve sixteen (22). Valve sixteen (22) is in the closed state to maintain the pressure of the first pipeline. At the same time, nitrogen enters the second pipeline, successively passing through check valve one (24). After being sucked by the plunger pump (2), it passes through check valve two (25) and enters the fixed - geometry interaction chamber jacket (5), and then enters the pipeline where valve sixteen (22) is located to maintain the pressure of the second pipeline.

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