A drug dissolution device using a circulation pool method

Abstract

A drug dissolution device using a circulation pool method, wherein the side fixing blocks are arranged at both ends of a liquid collecting tank; the cushion blocks are arranged at the bottom sides of both ends of the liquid collecting tank; the liquid tank top plate is arranged on the top surface of the liquid collecting tank; the water area base is fixed on the top surface of the liquid tank top plate; the water area upper cover is arranged on the top surface of the water area base; knob fixing cylinders are arranged on both sides of the top surface of the water area upper cover, and the knobs are plug-connected with the knob fixing cylinders; the support rods are arranged on both sides of the outer wall of the water area base; the glass tube sleeve is fixed on the water area base and the water area upper cover; the circulation pool is embedded in the upper cover fixing hole; the side fixing plates are arranged on both sides of the liquid tank top plate; the shield connection block is arranged on the top side of the side fixing plates; the two ends of the shield fixing rod are rotatably arranged with the shield connection blocks on both sides through the rotating shaft; and the circulation pool back plate is arranged on one side of the circulation pool. The present invention enables the inner and outer sides of the circulation pool to form good channels for the flow of solvent and circulating water, respectively, and realizes precise temperature control by heat exchange between the water area and the solvent.

Description

Technical Field

[0001] The invention relates to the technical field of medical experimental equipment application, in particular to a circulation pool method drug dissolution device. Background Art

[0002] As a new dissolution concentration inspection method, the circulation cell method mainly relies on the continuous flushing of the preparation with flowing solvent, which can well simulate the circulation of drugs in the human body. Selecting appropriate cell accessories is suitable for tablets, capsules, patches, microspheres, suppositories, suspensions, stents, implants and liposomes, etc.

[0003] In the process of drug dissolution test by circulation cell method, the drug and the solvent are dissolved by circulating and flushing the drug in the circulation cell. The solvent after drug dissolution is circulated through the circulation system and sampled through the sampling system. When the drug is dissolved in the circulation cell, in order to make the drug dissolution process closer to the actual dissolution environment of the drug in the human body, the circulation cell needs to be insulated to simulate the body temperature of the human body so that the dissolution temperature of the solvent is controlled at 37°C. Now, a device that can control the temperature of the circulation cell is needed, which can perform efficient insulation treatment on the circulation cell, and the circulation cell and the device can be quickly assembled. Summary of the invention

[0004] In order to solve the above-mentioned problems, the present invention discloses a drug dissolution device using a circulation cell method, and its specific technical scheme is as follows: A drug dissolution device using a circulation cell method comprises a side fixing block, a liquid collecting tank, a liquid drain pipe, a cushion block, a liquid tank top plate, a water area base, a water area upper cover, a knob, a support rod, a glass tube, a circulation cell, a side fixing plate, a mask connecting block, a mask fixing rod, a circulation cell mask and a circulation cell back plate;

[0005] The side fixing blocks are arranged at both ends of the liquid collecting tank, and the side fixing blocks are assembled with the liquid collecting tank through fasteners; the cushion blocks are arranged at the bottom sides of both ends of the liquid collecting tank, and the cushion blocks are assembled with the side fixing blocks through fasteners; the side wall of the liquid collecting tank is provided with a liquid collecting tank side hole, and the bottom end of the liquid collecting tank is provided with a liquid collecting tank bottom hole, and one end of the drainage pipe is assembled and connected with the liquid collecting tank bottom hole; the liquid tank top plate is arranged on the top surface of the liquid collecting tank, and the liquid tank top plate is assembled with the liquid collecting tank through fasteners; the water area base is fixed to the liquid collecting tank The top surface of the trough top plate is arranged in a horizontal array, a solvent inlet is arranged in the center of the water area base, one end of the solvent inlet is connected to a solvent inlet joint, a water area water inlet is arranged on one side of the water area base, and the water area water inlet is connected to a water area water inlet joint; the water area upper cover is arranged on the top surface of the water area base, a cover fixing hole is arranged in the center of the water area upper cover, a water area water outlet is arranged on one side of the water area upper cover, and the water area water outlet is connected to a water area water outlet joint; knob fixing cylinders are arranged on both sides of the top surface of the water area upper cover, and the knob is connected to the knob fixing cylinder. The fixed cylinder is plug-in connected; the support rod is arranged on both sides of the outer wall of the water area base, the bottom end of the support rod is vertically fixed to the top plate of the liquid tank, and the top end of the support rod is vertically fixed to the bottom surface of the water area cover; the glass tube sleeve is fixed on the water area base and the water area cover; the circulation pool is embedded in the upper cover fixing hole to realize the limited fixation of the circulation pool and the water area cover, and the bottom end of the circulation pool is plug-in connected with the solvent inlet joint; the side fixing plates are arranged on both sides of the liquid tank top plate, and are symmetrically arranged, and the side fixing plates on each side The bottom end is fixed to the top plate of the liquid tank by fasteners; the mask connecting block is arranged on the top side of the side fixing plate on each side, and is assembled with the side fixing plates by fasteners; the two ends of the mask fixing rod are rotatably arranged with the mask connecting blocks on both sides by a rotating shaft; the circulation pool mask is attached to the side wall of the mask connecting block, and the circulation pool mask is assembled with the mask fixing rod by fasteners; the circulation pool back plate is arranged on one side of the circulation pool, and the two sides of the circulation pool back plate are assembled with the side fixing plates on both sides by fasteners.

[0006] Furthermore, the length of the pad is longer than the width of the liquid collecting tank, and the two ends of the pad extend out of the two sides of the bottom surface of the liquid collecting tank; the bottom surface of each side of the pad is provided with rubber feet, and the rubber feet are fixed to the two ends of the bottom surface of each pad by plugging.

[0007] Furthermore, the number of the bottom holes of the liquid collecting trough is two, and each of the drain pipes is arranged in opposition to each of the bottom holes of the liquid collecting trough; the end of the drain pipe is flange-shaped, and one end of the drain pipe extends into the bottom hole of the liquid collecting trough, and the flange of the drain pipe fits into the inner bottom surface of the liquid collecting trough. The drain pipe is matched with the liquid collecting trough through fasteners to achieve vertical connection between the drain pipe and the liquid collecting trough.

[0008] Furthermore, the top surface of the water area base is in a layered structure to form a base platform, and the side wall of the base platform is circumferentially embedded with a base sealing ring, the bottom end of the glass tube is fitted into the outer wall of the base platform to achieve plug-in fixation, and the glass tube and the water area base are sealed by the base sealing ring; the water inlet of the water area passes through the top surface of the base platform.

[0009] Furthermore, the solvent inlet joint is arranged at the center of the top surface of the water area base, and the solvent inlet joint is arranged vertically to the water area base.

[0010] Furthermore, the water area cover is of a square structure; the center of the bottom surface of the water area cover is of a layered platform structure to form an upper cover platform; the side wall of the upper cover platform is circumferentially embedded with an upper cover sealing ring; the top end of the glass tube is fitted on the outer wall of the upper cover platform to achieve plug-in fixation; the glass tube and the water area cover are sealed by the upper cover sealing ring; the water outlet of the water area is connected to the bottom surface of the upper cover platform.

[0011] Furthermore, the solvent inlet joint, the water inlet joint and the water outlet joint of the water area are all Luer joints.

[0012] Furthermore, the support rod and the upper cover of the water area are arranged obliquely, the knob fixing tube and the upper cover of the water area are arranged obliquely, and the support rod and the knob fixing tube are arranged in a cross shape.

[0013] Furthermore, the bottom end of the knob extends into the corresponding knob fixing tube, and the knob is fixed to the knob fixing tube by threads; the side wall of each knob is provided with a knob fixing sheet, and the knob fixing sheet is arranged vertically to the knob. The structural principle of the present invention is:

[0014] When the device is used, the drug is fixed in the circulation pool through the drug support structure, and the circulation pool is inserted into the fixing hole of the upper cover, the bottom end of the circulation pool is plugged and fixed with the solvent inlet joint, and then the knob is rotated to make the knob fixing piece buckle with the end of the circulation pool; the solvent flows into the circulation through the solvent inlet joint through the solvent inlet, and after the solvent and the drug are flushed and dissolved, the solvent is discharged through the top of the circulation pool; the circulating water flows into the glass tube through the water area water inlet joint through the water area water inlet, and the circulating water exchanges heat and insulates the side wall of the circulation pool. After the circulating water fills the glass tube, the circulating water flows through the water area water outlet through the water area water outlet joint and is discharged, and is connected to the side hole of the collecting tank through a pipeline, and the discharged circulating water is collected in the collecting tank and discharged from the bottom hole of the collecting tank.

[0015] The beneficial effects of the present invention are:

[0016] The present invention performs a water area insulation design on the flow cell structure of the flow cell method, inserts the flow cell into a glass tube for fixing, and fills the glass tube with circulating water for circulation, so that good solvent flow and circulating water flow channels are formed inside and outside the flow cell respectively, and the circulating water forms a water area on the outside of the flow cell for wrapping and heat exchange, and the heat exchange process is efficient, so that the dissolution process of the drug and the solvent in the flow cell is at a constant set temperature, thereby realizing accurate temperature control of the drug dissolution test;

[0017] The overall structure of the device is compact, the circulation pool can be quickly connected to the glass tube structure by plugging, and can be quickly pressed and fixed by the knob structure to form a good sealing structure. At the same time, the circulating water has a smooth circulating water flow path, and the device structure is exquisitely designed. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 It is a schematic diagram of the overall appearance structure of the present invention.

[0019] Figure 2 It is a schematic diagram of the overall internal structure of the present invention.

[0020] Figure 3 It is a front view of the present invention as a whole.

[0021] Figure 4 It is a front cross-sectional view of the present invention as a whole.

[0022] Figure 5 It is a cross-sectional view of a single glass tube structure of the present invention.

[0023] List of reference numerals:

[0024] Side fixing block 1;

[0025] Liquid collecting tank 2;

[0026] The side hole 2-1 of the liquid collecting tank and the bottom hole 2-2 of the liquid collecting tank;

[0027] Drain pipe 3;

[0028] Pad 4;

[0029] Rubber feet 4-1;

[0030] Liquid tank top plate 5;

[0031] Water base 6;

[0032] Solvent inlet 6-1, solvent inlet joint 6-2, water inlet of water area 6-3, water inlet joint of water area 6-4, base platform 6-5, base sealing ring 6-6;

[0033] Water area cover 7;

[0034] Upper cover fixing hole 7-1, water outlet of water area 7-2, water outlet joint of water area 7-3, knob fixing tube 7-4, upper cover platform 7-5, upper cover sealing ring 7-6;

[0035] Knob 8;

[0036] Knob fixing plate 8-1;

[0037] Support rod 9;

[0038] Glass tube 10;

[0039] Circulation cell 11;

[0040] Side fixing plate 12;

[0041] Shield connection block 13;

[0042] Shield fixing rod 14;

[0043] Circulation cell shield 15;

[0044] Flow cell back plate 16. DETAILED DESCRIPTION

[0045] In order to make the technical solution of the present invention clearer, the present invention is further described below in conjunction with the accompanying drawings. Any equivalent replacement of the technical features of the technical solution of the present invention and any solution derived by conventional reasoning shall fall within the protection scope of the present invention. The fixed connection, fixed setting, and fixed structure mentioned in this embodiment are all well-known technologies known to those skilled in the art such as gluing, welding, screw connection, bolt and nut connection, and riveting.

[0046] As shown in the accompanying drawings, a drug dissolution device using a circulation cell method includes a side fixing block 1, a liquid collecting tank 2, a liquid drain pipe 3, a cushion block 4, a liquid tank top plate 5, a water area base 6, a water area upper cover 7, a knob 8, a support rod 9, a glass tube 10, a circulation cell 11, a side fixing plate 12, a mask connecting block 13, a mask fixing rod 14, a circulation cell mask 15 and a circulation cell back plate 16;

[0047] The side fixing blocks 1 are arranged at both ends of the liquid collecting tank 2, and the side fixing blocks 1 are assembled with the liquid collecting tank 2 by fasteners; the cushion blocks 4 are arranged at the bottom sides of both ends of the liquid collecting tank 2, and the cushion blocks 4 are assembled with the side fixing blocks 1 by fasteners; the side wall of the liquid collecting tank 2 is provided with a liquid collecting tank side hole 2-1, and the bottom end of the liquid collecting tank 2 is provided with a liquid collecting tank bottom hole 2-2, and one end of the drainage pipe 3 is assembled and connected with the liquid collecting tank bottom hole 2-2; the liquid tank top plate 5 is arranged on the top surface of the liquid collecting tank 2, and the liquid tank top plate 5 is assembled with the liquid collecting tank 2 by fasteners; the water area base 6 is fixed to the liquid tank top plate 5 The top surface of the water area base 6 is arranged in a horizontal array, a solvent inlet is provided at the center of the water area base 6, one end of the solvent inlet is connected to a solvent inlet joint 6-2, a water area water inlet 6-3 is provided on one side of the water area base 6, and the water area water inlet 6-3 is connected to a water area water inlet joint 6-4; the water area upper cover 7 is arranged on the top surface of the water area base 6, a cover fixing hole 7-1 is provided at the center of the water area upper cover 7, a water area water outlet 7-2 is provided on one side of the water area upper cover 7, and the water area water outlet 7-2 is connected to a water area water outlet joint 7-3; knob fixing tubes 7-4 are provided on both sides of the top surface of the water area upper cover 7, and the knob 8 is connected to the knob 8. The button fixing tube 7-4 is plug-connected; the support rod 9 is arranged on both sides of the outer wall of the water area base 6, the bottom end of the support rod 9 is vertically fixed to the liquid tank top plate 5, and the top end of the support rod 9 is vertically fixed to the bottom surface of the water area cover 7; the glass tube 10 is fixedly fitted on the water area base 6 and the water area cover 7; the circulation pool 11 is embedded in the upper cover fixing hole 7-1 to realize the limited fixation of the circulation pool 11 and the water area cover 7, and the bottom end of the circulation pool 11 is plug-connected with the solvent inlet joint 6-2; the side fixing plates 12 are arranged on both sides of the liquid tank top plate 5, and are symmetrically arranged, with the side fixing plates on each side The bottom end of 12 is fixed to the liquid tank top plate 5 by fasteners; the mask connecting block 13 is arranged on the top side of the side fixing plate 12 on each side, and is assembled with the side fixing plate 12 by fasteners; the two ends of the mask fixing rod 14 are rotatably arranged with the mask connecting blocks 13 on both sides through a rotating shaft; the circulation pool mask 15 is attached to the side wall of the mask connecting block 13, and the circulation pool mask 15 is assembled with the mask fixing rod 14 by fasteners; the circulation pool back plate 16 is arranged on one side of the circulation pool 11, and the two sides of the circulation pool back plate 16 are assembled with the side fixing plates 12 on both sides by fasteners.

[0048] Furthermore, the length of the pad 4 is longer than the width of the liquid collecting tank 2, and the two ends of the pad 4 extend out of the two sides of the bottom surface of the liquid collecting tank 2; the bottom surface of each side of the pad 4 is provided with a rubber foot 4-1, and the rubber foot 4-1 is fixed to the two ends of the bottom surface of each pad 4 by plugging.

[0049] Furthermore, the number of the bottom holes 2-2 of the liquid collecting trough 2 is two, and each of the drain pipes 3 is arranged in opposition to each of the bottom holes 2-2 of the liquid collecting trough; the end of the drain pipe 3 is flange-shaped, and one end of the drain pipe 3 extends into the bottom hole 2-2 of the liquid collecting trough, and the flange of the drain pipe 3 fits into the inner bottom surface of the liquid collecting trough 2. The drain pipe 3 is matched with the liquid collecting trough 2 through fasteners, so that the drain pipe 3 and the liquid collecting trough 2 are vertically connected.

[0050] Furthermore, the top surface of the water area base 6 is in a layered structure, forming a base platform 6-5, and the side wall of the base platform 6-5 is circumferentially embedded with a base sealing ring 6-6, and the bottom end of the glass tube 10 is fitted on the outer wall of the base platform 6-5 to achieve plug-in fixation, and the glass tube 10 and the water area base 6 are sealed by the base sealing ring 6-6; the water inlet 6-3 of the water area passes through the top surface of the base platform 6-5.

[0051] Furthermore, the solvent inlet joint 6 - 2 is arranged at the center of the top surface of the water area base 6 , and the solvent inlet joint 6 - 2 is arranged vertically to the water area base 6 .

[0052] Furthermore, the water area cover 7 is of a square structure; the center of the bottom surface of the water area cover 7 is of a layered platform structure, forming an upper cover platform 7-5, and the side wall of the upper cover platform 7-5 is circumferentially embedded with an upper cover sealing ring 7-6, the top end of the glass tube 10 is fitted on the outer wall of the upper cover platform 7-5 to achieve plug-in fixation, and the glass tube 10 and the water area cover 7 are sealed by the upper cover sealing ring 7-6; the water outlet 7-2 of the water area is connected to the bottom surface of the upper cover platform 7-5.

[0053] Furthermore, the solvent inlet connector 6-2, the water inlet connector 6-4 and the water outlet connector 7-3 are all Luer connectors.

[0054] Furthermore, the support rod 9 is disposed obliquely to the water area cover 7, the knob fixing tube 7 - 4 is disposed obliquely to the water area cover 7, and the support rod 9 and the knob fixing tube 7 - 4 are disposed in a cross shape.

[0055] Furthermore, the bottom end of the knob 8 extends into the corresponding knob fixing tube 7-4, and the knob 8 is threadedly fixed to the knob fixing tube 7-4; the side wall of each knob 8 is provided with a knob fixing plate 8-1, and the knob fixing plate 8-1 is vertically arranged to the knob 8.

[0056] The structural principle of the present invention is:

[0057] When the device is used, the drug is fixed in the circulation pool through the drug support structure, and the circulation pool is inserted into the fixing hole of the upper cover, the bottom end of the circulation pool is plugged and fixed with the solvent inlet joint, and then the knob is rotated to make the knob fixing piece buckle with the end of the circulation pool; the solvent flows into the circulation through the solvent inlet joint through the solvent inlet, and after the solvent and the drug are flushed and dissolved, the solvent is discharged through the top of the circulation pool; the circulating water flows into the glass tube through the water area water inlet joint through the water area water inlet, and the circulating water exchanges heat and insulates the side wall of the circulation pool. After the circulating water fills the glass tube, the circulating water flows through the water area water outlet through the water area water outlet joint and is discharged, and is connected to the side hole of the collecting tank through a pipeline, and the discharged circulating water is collected in the collecting tank and discharged from the bottom hole of the collecting tank.

[0058] The beneficial effects of the present invention are:

[0059] The present invention performs a water area insulation design on the flow cell structure of the flow cell method, inserts the flow cell into a glass tube for fixing, and fills the glass tube with circulating water for circulation, so that good solvent flow and circulating water flow channels are formed inside and outside the flow cell respectively, and the circulating water forms a water area on the outside of the flow cell for wrapping and heat exchange, and the heat exchange process is efficient, so that the dissolution process of the drug and the solvent in the flow cell is at a constant set temperature, thereby realizing accurate temperature control of the drug dissolution test;

[0060] The overall structure of the device is compact, the circulation pool can be quickly connected to the glass tube structure by plugging, and can be quickly pressed and fixed by the knob structure to form a good sealing structure. At the same time, the circulating water has a smooth circulating water flow path, and the device structure is exquisitely designed.

Claims

1. A drug dissolution device using a flow cell method, characterized in that: It comprises a side fixing block (1), a liquid collecting tank (2), a liquid discharge pipe (3), a cushion block (4), a liquid tank top plate (5), a water area base (6), a water area upper cover (7), a knob (8), a support rod (9), a glass tube (10), a circulation pool (11), a side fixing plate (12), a shield connecting block (13), a shield fixing rod (14), a circulation pool shield (15) and a circulation pool back plate (16); The side fixing blocks (1) are arranged at both ends of the liquid collecting trough (2), and the side fixing blocks (1) are assembled with the liquid collecting trough (2) by means of fasteners; the cushion blocks (4) are arranged at the bottom sides of both ends of the liquid collecting trough (2), and the cushion blocks (4) are assembled with the side fixing blocks (1) by means of fasteners; the side wall of the liquid collecting trough (2) is provided with a liquid collecting trough side hole (2-1), the bottom end of the liquid collecting trough (2) is provided with a liquid collecting trough bottom hole (2-2), and one end of the liquid discharge pipe (3) is assembled and communicated with the liquid collecting trough bottom hole (2-2); the liquid trough top plate (5) is arranged on the top surface of the liquid collecting trough (2), and the liquid trough top plate (5) is assembled with the liquid collecting trough (2) by means of fasteners; the water area base (6) is fixed to the liquid trough The top surface of the top plate (5) is arranged in a horizontal array, a solvent inlet is provided at the center of the water area base (6), one end of the solvent inlet is connected to a solvent inlet joint (6-2), a water area water inlet (6-3) is provided on one side of the water area base (6), and the water area water inlet (6-3) is connected to a water area water inlet joint (6-4); the water area upper cover (7) is arranged on the top surface of the water area base (6), a cover fixing hole (7-1) is provided at the center of the water area upper cover (7), a water area water outlet (7-2) is provided on one side of the water area upper cover (7), and the water area water outlet (7-2) is connected to a water area water outlet joint (7-3); knob fixing cylinders (7-4) are provided on both sides of the top surface of the water area upper cover (7), and the knob (8) The support rod (9) is arranged on both sides of the outer wall of the water area base (6), the bottom end of the support rod (9) is vertically fixed to the liquid tank top plate (5), and the top end of the support rod (9) is vertically fixed to the bottom surface of the water area upper cover (7); the glass tube (10) is sleeved and fixed on the water area base (6) and the water area upper cover (7); the circulation pool (11) is embedded in the upper cover fixing hole (7-1) to realize the limited fixation of the circulation pool (11) and the water area upper cover (7), and the bottom end of the circulation pool (11) is plugged and connected to the solvent inlet joint (6-2); the side fixing plates (12) are arranged on both sides of the liquid tank top plate (5), and are symmetrically arranged, with each side having a The bottom end of the side fixing plate (12) is fixed to the liquid tank top plate (5) by fasteners; the shield connection block (13) is arranged on the top side of each side of the side fixing plate (12) and is assembled with the side fixing plate (12) by fasteners; the two ends of the shield fixing rod (14) are rotatably arranged with the shield connection blocks (13) on both sides by a rotating shaft; the circulation pool shield (15) is attached to the side wall of the shield connection block (13), and the circulation pool shield (15) is assembled with the shield fixing rod (14) by fasteners; the circulation pool back plate (16) is arranged on one side of the circulation pool (11), and the two sides of the circulation pool back plate (16) are assembled with the side fixing plates (12) on both sides by fasteners.

2. A flow cell drug dissolution device according to claim 1, characterized in that: The length of the cushion block (4) is longer than the width of the liquid collecting tank (2), and the two ends of the cushion block (4) extend out of the two sides of the bottom surface of the liquid collecting tank (2); the bottom surface of each side of the cushion block (4) is provided with a rubber foot (4-1), and the rubber foot (4-1) is fixed to the two ends of the bottom surface of each cushion block (4) by plugging.

3. A flow cell drug dissolution device according to claim 1, characterized in that: The number of the bottom holes (2-2) of the liquid collecting trough (2) is two, and each of the drainage pipes (3) is arranged in a counterposition with each of the bottom holes (2-2) of the liquid collecting trough; the end of the drainage pipe (3) is flange-shaped, and one end of the drainage pipe (3) extends into the bottom hole (2-2) of the liquid collecting trough, and the flange of the drainage pipe (3) fits the inner bottom surface of the liquid collecting trough (2); the drainage pipe (3) cooperates with the liquid collecting trough (2) through a fastener, so that the drainage pipe (3) and the liquid collecting trough (2) are vertically connected.

4. A flow cell drug dissolution device according to claim 1, characterized in that: The top surface of the water area base (6) is in a layered structure, forming a base layer platform (6-5); the side wall of the base layer platform (6-5) is circumferentially embedded with a base sealing ring (6-6); the bottom end of the glass tube (10) is sleeved on the outer wall of the base layer platform (6-5) to achieve plug-in fixation; the glass tube (10) and the water area base (6) are sealed by the base sealing ring (6-6); the water inlet (6-3) of the water area passes through the top surface of the base layer platform (6-5).

5. A flow cell drug dissolution device according to claim 1, characterized in that: The solvent inlet joint (6-2) is arranged at the center of the top surface of the water area base (6), and the solvent inlet joint (6-2) and the water area base (6) are arranged vertically.

6. A drug dissolution device using a flow cell method according to claim 1, characterized in that: The water area upper cover (7) is in a square structure; the center of the bottom surface of the water area upper cover (7) is in a layered platform structure to form an upper cover platform (7-5); the side wall of the upper cover platform (7-5) is circumferentially embedded with an upper cover sealing ring (7-6); the top end of the glass tube (10) is sleeved on the outer wall of the upper cover platform (7-5) to achieve plug-in fixation; the glass tube (10) and the water area upper cover (7) are sealed by the upper cover sealing ring (7-6); the water outlet (7-2) of the water area is connected to the bottom surface of the upper cover platform (7-5).

7. A flow cell drug dissolution device according to claim 1, characterized in that: The solvent inlet connector (6-2), the water inlet connector (6-4) and the water outlet connector (7-3) are all Luer connectors.

8. A flow cell drug dissolution device according to claim 1, characterized in that: The support rod (9) and the water area upper cover (7) are arranged obliquely, the knob fixing tube (7-4) and the water area upper cover (7) are arranged obliquely, and the support rod (9) and the knob fixing tube (7-4) are arranged in a cross shape.

9. A flow cell drug dissolution device according to claim 1, characterized in that: The bottom end of the knob (8) extends into the corresponding knob fixing tube (7-4), and the knob (8) and the knob fixing tube (7-4) are threadedly fixed; a knob fixing sheet (8-1) is provided on the side wall of each knob (8), and the knob fixing sheet (8-1) is arranged vertically with the knob (8).

Images