Physiological signal monitoring device and sensor bracket thereof

Abstract

The present invention provides a physiological signal monitoring device and a bracket, wherein the bracket carries a sensor to measure the physiological signal of an analyte in a biological fluid, wherein the sensor has a signal detection end and a signal output end. The bracket comprises an implantation hole, a waterproof seal, and a diaphragm elastic member, wherein the implantation hole is an implantation channel for implanting the sensor and accommodating a part of the sensor; the waterproof seal is arranged above the implantation hole; and the diaphragm elastic member is arranged in the implantation hole to separate the implantation hole and cover the cross-sectional area of ​​the implantation hole.

Description

Technical Field

[0001] The present invention relates to a physiological signal monitoring device, and in particular to a thin physiological signal monitoring device. Background Art

[0002] Patients with chronic diseases (such as diabetes and chronic cardiovascular diseases) need to monitor the changes in certain physiological parameters (such as blood sugar, blood fat, cholesterol concentration or other parameters) on a daily basis in order to effectively control the disease to prevent it from worsening and obtain timely treatment.

[0003] However, many physiological data need to be obtained through invasive methods. In addition, in order to monitor effectively, it is necessary to obtain multiple measurement data every day. Taking blood sugar measurement as an example, traditional blood sugar measurement usually uses test strips and blood glucose meters to obtain blood sugar concentration by measuring the amount of current generated by the reaction of glucose in the blood with glucose oxidase in the test strip. This measurement method requires daily blood sampling from the fingertips and dripping the blood into the test strip to obtain a single blood sugar data. When patients need to obtain multiple measurement data, they must go through the discomfort of repeated blood sampling. In addition, for patients with large blood sugar fluctuations, the instantaneous blood sugar value is not enough to provide doctors with accurate medication basis.

[0004] In order to avoid patient discomfort caused by multiple blood draws or body fluid extractions, some technicians in this field tend to use small sensing components implanted in subcutaneous tissue for a relatively long time to match signal processing components with signal processing capabilities and reusable. Since this sensing component does not need to be removed daily, and data such as blood sugar, blood lipids, cholesterol concentrations or other data that can provide physiological parameters can be collected and analyzed at any time, real-time physiological data monitoring can be provided. Therefore, a thin physiological signal monitoring device that can be implanted subcutaneously for a long time is needed. Summary of the invention

[0005] The present invention provides a physiological signal monitoring device, which is suitable for long-term subcutaneous implantation and can monitor the patient's physiological data in real time.

[0006] One aspect of the present invention is to provide a physiological signal monitoring device for subcutaneous implantation to measure the physiological signal of an analyte in a biological fluid, comprising a sensor, a transmitter and a bracket. The sensor has a signal detection end and a signal output end, wherein the signal detection end is used to be implanted subcutaneously to detect the physiological signal, and the signal output end is used to output the physiological signal. The transmitter has a port to connect the signal output end of the sensor and to receive the physiological signal. The bracket is used to carry the sensor, and comprises an implantation hole, a waterproof seal and a diaphragm elastic member, wherein the implantation hole is an implantation channel for implanting the sensor and accommodating a part of the sensor, the waterproof seal is arranged above the implantation hole to abut against the transmitter to form a waterproof sealing structure, and the diaphragm elastic member is arranged in the implantation hole to separate the implantation hole and cover the cross-sectional area of ​​the implantation hole.

[0007] Another aspect of the present invention is to provide a bracket that carries a sensor to measure the physiological signal of an analyte in a biological fluid, wherein the sensor has a signal detection end and a signal output end, and the bracket includes an implantation hole, a waterproof seal, and a diaphragm elastic member, wherein the implantation hole is an implantation channel for implanting the sensor and accommodating a portion of the sensor, the waterproof seal is arranged above the implantation hole, and the diaphragm elastic member is arranged in the implantation hole to separate the implantation hole and cover the cross-sectional area of ​​the implantation hole.

[0008] Another aspect of the present invention is to provide a bracket, which carries a sensor to measure the physiological signal of an analyte in a biological fluid, wherein the sensor has a signal detection end and a signal output end, and the bracket includes an implantation hole, a diaphragm elastic member, a waterproof seal and a barrier member, wherein the implantation hole is used to implant an implantation channel for implanting the sensor and accommodate a portion of the sensor, the diaphragm elastic member is arranged in the implantation hole to separate the implantation hole and cover the cross-sectional area of ​​the implantation hole, the waterproof seal is arranged above the implantation hole, and the barrier member is arranged in the implantation hole to hold the sensor.

[0009] The physiological sensing device of the present invention achieves the purpose of thinness and detachability through the complementary structural design of the transmitter and the bracket, and utilizes the waterproof sealing effect of the elastic body to prevent liquid from penetrating from the outside and blood from seeping out from the implantation site. At the same time, the physiological sensing device of the present invention uses the limiting and fixing means of the filling body, the limiting member and the blocking member to make the sensor more stably supported on the bracket. BRIEF DESCRIPTION OF THE DRAWINGS

[0010] The present invention will be described in detail with reference to the following drawings for a clearer understanding of the present invention, in which:

[0011] Figure 1 is a perspective view of a physiological signal monitoring device of the present invention;

[0012] Figure 2A is a perspective exploded view of the physiological signal monitoring device of the present invention;

[0013] Figure 2B is another perspective exploded view of the physiological signal monitoring device of the present invention;

[0014] Figure 3 for Figure 1 a cross-sectional view along line I;

[0015] Figure 4 for Figure 1 Sectional view along line II;

[0016] Figure 5A is a perspective view of a support of the physiological signal monitoring device of the present invention;

[0017] Figure 5B for Figure 5A Exploded perspective view of

[0018] Figure 6 for Figure 5A A cross-sectional view of

[0019] Fig. 7A A perspective view of the support of the physiological signal monitoring device of the present invention from another angle;

[0020] Figure 7B for Fig. 7A Exploded perspective view of

[0021] Figure 8 A bottom view of a bracket of the physiological signal monitoring device of the present invention;

[0022] Fig. 9 is a cross-sectional view of another physiological signal monitoring device of the present invention;

[0023] Fig.10 is a perspective combined view of a bracket and a clamp according to a first embodiment of the present invention;

[0024] Fig.11A and Fig. 11B A perspective view and a cross-sectional view of a bracket according to a second embodiment of the present invention respectively;

[0025] Fig. 12A and Fig. 12B 3 and 4 are a perspective view and a cross-sectional view respectively of a bracket according to a third embodiment of the present invention. DETAILED DESCRIPTION

[0026] The present invention will be fully understood by the following examples, so that those skilled in the art can implement the present invention according to the examples. However, the implementation of the present invention is not limited to the following examples. It should be noted that in the following description, similar components are represented by the same number.

[0027] The physiological signal monitoring device of the present invention is used to monitor the physiological signal of the analyte in the biological fluid. The term "biological fluid" used herein refers to biological fluids such as blood, interstitial fluid, cerebrospinal fluid, lymph fluid, etc.

[0028] The term "analyte" used herein refers to a substance in the above-mentioned biological fluid that can reflect the physiological condition of an organism, including but not limited to sugars, proteins, fats, cholesterol, vitamins, hormones or other substances present in biological fluids. The term "physiological signal" used herein refers to data such as the content or concentration of the above-mentioned analyte. In one embodiment, the physiological signal is the glucose concentration in the human body, preferably the glucose concentration in the interstitial fluid. In certain embodiments, the content or concentration of metabolites, antigens, antibodies, etc. that are naturally present in biological fluids or endogenous may also constitute a physiological signal. Alternatively, the physiological signal may also be the content or concentration of an exogenous substance introduced into the body, for example, a chemical reagent, a drug, a pharmaceutical composition, or the concentration of a metabolite of a pharmaceutical composition. In one embodiment, the exogenous substance may be insulin or glucagon.

[0029] See also Figure 1 , which is a perspective view of the physiological signal monitoring device 1 of the present invention. The physiological signal monitoring device 1 of the present invention comprises a base 10, a bracket 20 (not shown), a transmitter 30 and a sensor 40 (not shown). The base 10 can be fixed on the skin surface of a biological body (such as a human body); the sensor 40 is fixed to the bracket 20; the bracket 20 is combined with the base 10; and the transmitter 30 is detachably arranged on the bracket 20.

[0030] See also Figure 2A , which is a perspective exploded view of the physiological signal monitoring device 1 of the present invention. The corresponding positions between the base 10, the bracket 20 carrying the sensor 40, and the transmitter 30 can be seen from the figure. When the user installs the physiological signal monitoring device 1, the base 10 must first be fixed to the skin surface, and the bracket 20 must be engaged with the base 10 using an additional implantation device (not shown) to implant the sensor 40 in the bracket 20 subcutaneously. After removing the implantation device, the bracket 20 is combined with the base 10 and fixed to the user's skin surface. The transmitter 30 is covered on the base 10 and electrically connected to the sensor 40 to receive the physiological signal from the sensor 40 and transmit the physiological signal to an external device. In order to show the direction in which the transmitter 30 is combined with the base 10, Figure 2A The upper surface 30A of the emitter 30 is shown in FIG.

[0031] See also Figure 2B , which is another perspective exploded view of the physiological signal monitoring device 1 of the present invention. In order to more clearly understand the corresponding structures between the base 10, the bracket 20 and the transmitter 30, Figure 2B 3 shows the lower surface 30B of the transmitter 30. The lower surface 30B of the transmitter 30 is provided with a first groove 34 and a pair of second grooves 36. The first groove 34 is used to accommodate the bracket 20 and the setting groove 14 of the base 10, and the second groove 36 is used to accommodate the pair of first engaging members 16 of the base 10. A second engaging member 38 is provided inside each second groove 36, and the position of the second engaging member 38 corresponds to the position of the first engaging member 16. When the transmitter 30 is combined with the base 10, the second engaging member 38 of each second groove 36 is engaged with its corresponding first engaging member 16. The components in each main structure will be described in sequence below.

[0032] Please continue reading Figure 2A and Figure 2B First, the structure of the base 10 is described. The base 10 includes a patch 11, a through hole 12, a base body 13, a setting groove 14, a first pair of parts 15, a pair of first engaging parts 16, two positioning columns 17 and a first elastic body 18. The patch 11 is arranged on the bottom surface of the base 10, and is used to fit the surface of the skin of the organism. The patch 11 includes a waterproof material to prevent sewage from penetrating through the patch 11 and contacting the wound, thereby avoiding the risk of wound infection. The through hole 12 is arranged through the setting groove 14, and is used to implant the signal detection end 44 of the sensor 40 under the skin of the organism. The setting groove 14 is used to accommodate the bracket 20. The base body 13 has a base edge, which corresponds to the edge shape of the transmitter 30, and the first pair of parts 15 is arranged on the base edge. When the transmitter 30 is covered on the base 10, the first pair of parts 15 is matched with the second pair of parts 32 on the transmitter 30. The first engaging member 15 and the second engaging member 32 are foolproof components. When the user places the transmitter 30 on the base 10, the user can distinguish the installation direction by appearance to achieve a foolproof effect. The pair of first engaging members 16 are convexly arranged on the top surface of the base body 13 and correspond to the second grooves 36 on the transmitter 30 respectively, and are used to engage with the bottom of the transmitter 30. When the bracket 20 is combined with the base 10, the two positioning posts 17 are accommodated in the positioning holes 26 at the bottom of the bracket 20 (such as Fig. 7A and Figure 7B As shown), the first elastic body 18 is disposed at the edge of the setting groove 14 to form an interference fit with the bracket 20, thereby providing the bracket 20 with a limited position and fixed position on the base 10.

[0033] like Figure 2BAs shown, each first engaging member 16 includes an engaging portion 16A. Each engaging portion 16A corresponds to the second engaging member 38 in the second groove 36 of the transmitter 30. When the engaging portion 16A is pushed by an external force, each engaging portion 16A rotates in a direction away from the respective second engaging member 38, so that the first engaging member 16 is separated from the second engaging member 38.

[0034] The first elastic body 18 is disposed on the setting groove 14 on the top surface of the base 10, and is formed by double injection molding of elastic material and the base body 13 to form an interference fit with the bracket 20 made of a harder material. In one embodiment, the first elastic body 18 is arranged on the setting groove 14 to form a groove to accommodate the bracket 20. Preferably, the first elastic body 18 is arranged on the inner surface, outer surface and top surface of the groove peripheral wall of the setting groove 14. In another embodiment, the first elastic body 18 is dispersedly arranged on the setting groove 14 to define a fixing area so that the bracket 20 is accommodated in the fixing area. Preferably, the first elastic body 18 is dispersedly arranged on the inner surface, outer surface and top surface of the groove peripheral wall of the setting groove 14.

[0035] like Figure 3 and Figure 4 As shown, the port 342 further includes a printed circuit board 33 in the transmitter 30, the printed circuit board 33 includes a through hole 332, and the top end of the sensor 40 is received in the through hole 332 to reduce the height required for connecting the transmitter 30 with the bracket 20. The through hole 332 at least partially penetrates the printed circuit board 33.

[0036] Next, the structure of the bracket 20 will be described. Figure 5A , Figure 5B and Figure 6 , which are respectively a perspective view, a perspective exploded view and a cross-sectional view of the bracket 20 of the physiological signal monitoring device 1 of the present invention. The bracket 20 has a receiving groove 22, and the receiving groove 22 is used to accommodate a sensor 40 therein, wherein the sensor 40 is a sheet-like sensor. The sensor 40 has a signal output terminal 42, a signal detection terminal 44 and a connecting section 46 connecting the signal output terminal 42 and the signal detection terminal 44, wherein the signal output terminal 42 is accommodated in the receiving groove 22 and partially protrudes from the receiving groove 22, and is used to be electrically connected to the port 342 of the transmitter 30 and output the physiological signal to the transmitter 30, and the signal detection terminal 44 is implanted under the skin of the biological body to detect the physiological signal. There are intervals S1 and S2 between the wall of the receiving groove 22 and the sensor 40 to accommodate the corresponding structure of the transmitter 30. As shown Figure 2B and Figure 4As shown, the lower surface 30B of the transmitter 30 has a first groove 34, and a port 342 having a slot 344 is disposed in the first groove 34. The port 342 protrudes relative to the receiving groove 22 of the bracket 20 and is received in the receiving groove 22, so that the sensor 40 is inserted into the slot 344 in the port 342, so that the signal output end 42 is electrically connected to the port 342, and the port 342 is complementarily received in the intervals S1 and S2 of the receiving groove 22. By matching the structure of the sensor 40 with the spatial arrangement of the bracket 20, the bracket 20 provided by the present invention can be suitable for a thin design.

[0037] The support 20 also has an implantation hole 24, wherein the implantation hole 24 corresponds to the through hole 12 on the base 10, and together with the through hole 12 forms an implantation channel for the sensor 40, the implantation channel is used for the implantation needle (not shown) of the implantation device to penetrate, and the signal detection end 44 of the sensor 40 is implanted into the subcutaneous tissue of the organism. The implantation hole 24 passes through the upper surface and the lower surface of the support 20 and is interconnected with the receiving groove 22 to accommodate a part of the sensor 40.

[0038] See also Figure 3 , Figure 6 , Fig. 7A , Figure 7B and Figure 8 ,like Figure 6 , Fig. 7A and Figure 7B As shown, the bracket 20 has a fixing groove 27 for fixing the sensor 40, wherein the fixing groove 27 is connected to the receiving groove 22, and the implantation hole 24 and the receiving groove 22 are connected to each other through the fixing groove 27. Since the sensor 40 has a turning shape, the signal output end 42 is received in the receiving groove 22, and the signal detection end 44 extends downward along the axial direction of the implantation hole 24, and is thus penetrated by the bracket 20. The implantation hole 24 and the receiving groove 22 are located at two different vertical axes (such as Figure 6 As shown by the virtual axis, the signal detection end 44 and the signal output end 42 of the sensor 40 are located in the vertical axis of the implantation hole 24 and the receiving groove 22 respectively.

[0039] The support 20 also has a second elastic body 25, which includes a waterproof seal 25A, a transverse elastic member 25B and a barrier 25C. The waterproof seal 25A is disposed above the implant hole 24, preferably protruding from the outer edge of the implant hole 24, so as to abut against the transmitter 30 to form a waterproof seal structure. The waterproof seal 25A corresponds to the mating portion 346 (such as the port 342 of the transmitter 30) of the port 342 of the transmitter 30. Figure 2B As shown), the mating portion 346 complementarily interferes with the waterproof seal 25A (as shown Figure 3As shown in the figure, a complementary waterproof sealing structure is formed to prevent liquid from the outside from penetrating between the transmitter 30 and the base 10 and affecting the electrical performance of the transmitter 30 and the detection sensitivity of the sensor 40. With the above waterproof design, the user does not need to worry about the external liquid or sweat affecting the physiological signal monitoring device 1 of the present invention. When wearing the physiological signal monitoring device 1 of the present invention, the user can still carry out normal daily activities such as bathing and exercising.

[0040] The diaphragm elastic member 25B is disposed in the implantation hole 24 and is located above the implantation channel defined by the implantation hole 24 and the through hole 12 to separate the implantation hole 24 and cover the cross-sectional area of ​​the implantation hole 24. With the design of the diaphragm elastic member 25B, when the implantation needle of the implantation device passes through the diaphragm elastic member 25B and drives the signal detection end 44 to be implanted subcutaneously and then withdrawn, the diaphragm elastic member 25B, due to its own elastic force, closes the hole punctured by the implantation needle, thereby preventing the blood flowing back through the implantation channel from seeping toward the transmitter 30 and causing possible discomfort to the user.

[0041] In order to prevent blood from flowing back through the implantation channel and damaging the electronic components in the transmitter 30, the present invention sets a seal 12A on the through hole 12 of the base 10, and sets a diaphragm elastic member 25B in the implantation hole 24 of the bracket 20 to seal the through hole 12 and the implantation hole 24 respectively. The setting of the seal 12A and the diaphragm elastic member 25B prevents the blood seeping from the implantation site on the skin surface of the biological body from penetrating into the transmitter 30 through the above-mentioned implantation channel, so as to prevent the electronic components inside the transmitter 30 from being contaminated. The material of the seal 12A and the diaphragm elastic member 25B can be an elastomer (such as rubber), so that after the implantation needle is withdrawn, they can be tightly pressed against the signal detection end 44 of the sensor 40 to maintain the sealing inside the device. Furthermore, if the bottom of the bracket 20 is sealed by glue injection or any other sealing form, the seal 12A can also be omitted. In other embodiments, one of the seal 12A and the diaphragm elastic member 25B can be set.

[0042] The barrier 25C is disposed between the implantation hole 24 and the fixing groove 27 to hold the connecting section 46 of the sensor 40 to fix the sensor 40. In the present invention, the waterproof seal 25A and the diaphragm elastic member 25B are made of rubber, but may also be other elastic materials to prevent liquid leakage, without limitation thereto. The barrier 25C may be an elastic member or a non-elastic member. In one embodiment, the waterproof seal 25A, the diaphragm elastic member 25B and the barrier 25C are an integrally formed member and are embedded in the implantation hole 24. In other embodiments, the waterproof seal 25A, the diaphragm elastic member 25B and the barrier 25C may also be independent components.

[0043] like Fig. 7A , Figure 7B and Figure 8As shown, a plurality of limit members 29 are provided at the bottom of the bracket 20, and these limit members 29 are provided between the receiving groove 22 and the fixing groove 27 to stop the sensor 40. The plurality of limit members 29 may include at least one hook portion 29A and a stop portion 29B. When the sensor 40 is inserted into the bracket 20 from the fixing groove 27, the signal output end 42 of the sensor 40 is provided and protrudes from the receiving groove 22, the connecting section 46 is connected to the signal detection end 44 and is provided in the fixing groove 27, and the signal detection end 44 extends from the implantation hole 24. In addition, the hook portion 29A of the limit member 29 is used to provide a limiting function for the connecting section 46, and the stop portion 29B of the limit member 29 is used to hold the connecting section 46. Without affecting the functions of the hook portion 29A and the stop portion 29B, the plurality of limit members 29 of the present invention may be staggered or symmetrically arranged.

[0044] Fig. 9 FIG. 2 is a cross-sectional view of another physiological signal monitoring device 1 of the present invention, which only shows the external contour of the physiological signal monitoring device 1 of the present invention and the structure of the sensor 40 and the second elastic body 25. In this physiological signal monitoring device 1, the bracket 20 and the sensor 30 are integrally formed, and the bracket 20 and the transmitter 30 directly cover the sensor 40 during injection molding to encapsulate the sensor 40 in the physiological signal monitoring device 1. The implantation hole 24 is provided in the integrally formed bracket 20 and the transmitter 30, wherein the opening of one end of the implantation hole 24 is located below the bracket 20, and the opening of the other end of the implantation hole 24 is located above the transmitter 30. The implantation hole 24 is an implantation channel for implanting the sensor 40 and accommodates a part of the sensor 40. The waterproof seal 25A is provided above the implantation hole 24, and the diaphragm elastic member 25B is provided in the implantation hole 24 to separate the implantation hole 24 and cover the cross-sectional area of ​​the implantation hole 24. Preferably, a barrier 25C can be provided in the implantation hole 24 to hold the sensor 40. The second elastic body 25 can be formed by double injection molding of elastic material and the physiological signal monitoring device 1. By disposing the waterproof seal 25A and the diaphragm elastic member 25B in the implant hole 24, the physiological signal monitoring device 1 of the present invention can achieve the waterproof sealing effect and the function of fixing the sensor 40.

[0045] After the sensor 40 is fixed to the bracket 20, the bottom of the bracket 20 is further sealed. The present invention provides a filler ( Fig. 7A , Figure 7B , Figure 8 and Fig.10 The area indicated by dots in the figure is used to fix the sensor 40 and prevent external liquid from flowing from the through hole 12 of the base 10 to between the emitter 30 and the bracket 21. According to the first embodiment of the present invention, the bottom of the bracket 20 is filled with colloid 28. Fig.10As shown, a clamp 50 having an appearance matching the receiving groove 22 is inserted into the receiving groove 22 from the top surface of the bracket 20, and the signal output end 42 of the sensor 40 is clamped to ensure that the colloid 28 does not overflow. The colloid 28 is injected into the fixing groove 27 from the bottom surface of the bracket 20. Specifically, the colloid 28 can fill the fixing groove 27 and be blocked by the blocking member 25C without overflowing into the implantation hole 24. However, the degree of injection can be changed depending on the required sealing and other component structures, and the present invention is not limited to the embodiment. After the colloid 28 solidifies, the clamp 50 is removed.

[0046] According to the second embodiment of the present invention, the bracket 20 is an integral injection-molded component. For example, the bracket 20 directly covers the sensor 40 during injection molding, so that the sensor 40 is partially encapsulated in the bracket 20 . Fig. 11B Display edge Fig.11A In this embodiment, the stopper 29 and the blocking member 25C can be omitted.

[0047] Fig. 12A is a perspective view of a bracket 20 according to a third embodiment of the present invention, and Fig. 12B Display edge Fig.11A According to the third embodiment of the present invention, the bottom of the bracket 20 is sealed by filling the fixing groove 27 with an insert 20A instead of glue, so as to seal the bottom of the bracket 20 and fix the sensor 40. Preferably, the insert 20A is a bottom cover.

[0048] Through the above detailed description, it can be understood that the physiological signal monitoring device 1 of the present invention has the following advantages compared with the prior art:

[0049] 1. Thin design

[0050] like Figure 6 As shown, in order to match the turning shape of the sensor 40, the implantation hole 24 and the receiving groove 22 of the bracket 20 are located in two different vertical axes and are connected to each other, so that the sensor 40 can be inserted into the bracket 20. By matching the structure of the sensor 40 and the spatial arrangement of the bracket 20, the bracket 20 provided by the present invention can be suitable for a thin design.

[0051] In the assembly part of the transmitter 30 and the bracket 20, the port 342 of the transmitter 30 is accommodated in the interval S1 of the receiving groove 22 of the bracket 20. In addition, since the signal output end 42 of the sensor 40 partially protrudes from the receiving groove 22 of the bracket 20, the top of the bracket 20 is lower than the top of the signal output end 42, so that the signal output end 42 protrudes from the bracket 20 and is accommodated in the slot 344 of the port 342 and the through hole 332 of the printed circuit board 33 (as shown in FIG. Figure 3 and Figure 4 The purpose of thinness and detachability is achieved by the complementary structural design.

[0052] 2. Waterproof sealing effect

[0053] The second elastic body 25 disposed in the implantation hole 24 of the bracket 20 in the present invention includes a waterproof seal 25A and a diaphragm elastic member 25B, wherein the waterproof seal 25A abuts against the transmitter 30 to form a waterproof sealing structure to prevent liquid from the outside from penetrating between the transmitter 30 and the base 10 and affecting the electrical performance of the transmitter 30 and the detection sensitivity of the sensor 40, and the diaphragm elastic member 25B is disposed in the implantation hole 24 and corresponds to the implantation channel defined by the implantation hole 24 and the through hole 12, so as to prevent the blood flowing back through the implantation channel from seeping toward the transmitter 30.

[0054] 3. Sensor fixing effect

[0055] The bracket 20 of the present invention is used to carry the sensor 40. In addition to filling the fixing groove 27 with a filling body to fix the sensor 40, a plurality of stoppers 29 provided at the bottom of the bracket 20 are also used to fix the sensor 40. In addition, the barrier 25C of the second elastic body 25 holds the connecting section 46 of the sensor 40 to fix the sensor 40. Therefore, the present invention uses the stopper and fixation means of the filling body, the stopper 29 and the stopper 25C to make the sensor 40 more stably carried on the bracket 20.

[0056] Although the present invention is disclosed as above with reference to preferred embodiments, it is not intended to limit the scope of the present invention. Changes and modifications made by those skilled in the art without departing from the spirit and scope of the present invention should all fall within the scope of the present invention.

[0057] This application claims priority to U.S. Provisional Patent Application No. 62 / 882,140, ​​filed on August 2, 2019, the entire contents of which are incorporated herein by reference.

[0058] Description of Reference Numerals

[0059] 1 Physiological signal monitoring device

[0060] 10 Base

[0061] 11 Patches

[0062] 12 Through holes

[0063] 12A Seal

[0064] 13 Base body

[0065] 14 Setting slot

[0066] 15 The first pair of parts

[0067] 16 first engaging member

[0068] 16A Clamping part

[0069] 17 Positioning column

[0070] 18 First Elastic Body

[0071] 20 Bracket

[0072] 22 Receiving slot

[0073] 24 Implantation hole

[0074] 25 Second elastic body

[0075] 25A Waterproof Seal

[0076] 25B Diaphragm elastic member

[0077] 25C Barrier

[0078] 26 Positioning holes

[0079] 27 Fixing slot

[0080] 28 Colloid

[0081] 29 Limiting parts

[0082] 29A Hook

[0083] 29B Stop

[0084] 30 Transmitters

[0085] 30A Top surface

[0086] 30B Lower surface

[0087] 32 Second pair of parts

[0088] 33 Printed Circuit Board

[0089] 332 through hole

[0090] 34 First groove

[0091] Port 342

[0092] 344 slots

[0093] 346 Coordination

[0094] 36 Second groove

[0095] 38 second engaging member

[0096] 40 Sensors

[0097] 42 Signal output terminal

[0098] 44 Signal detection terminal

[0099] 46 Connection segment

[0100] 50 Clamp

[0101] S1, S2 interval

Claims

1. A physiological signal monitoring device for subcutaneous implantation to measure a physiological signal of an analyte in a biological fluid, comprising: A sensor having a signal detection end and a signal output end, wherein the signal detection end is used to be implanted subcutaneously to detect the physiological signal, and the signal output end is used to output the physiological signal; a transmitter having a port for connecting to the signal output end of the sensor and for receiving the physiological signal; as well as A bracket, which is used to carry the sensor, and the bracket includes: An implantation hole, which is an implantation channel for implanting the sensor and accommodates a portion of the sensor; A fixing groove, used for fixing the sensor; A waterproof sealing member, which is disposed above the implantation hole to abut against the transmitter to form a waterproof sealing structure; a diaphragm elastic member disposed in the implant hole to separate the implant hole and cover the entire cross-sectional area of ​​the implant hole; and A barrier is disposed between the implantation hole and the fixing groove to hold the sensor. 2 . The physiological signal monitoring device according to claim 1 , further comprising a base, wherein the bracket comprises two positioning holes, and the base comprises two positioning columns, and the two positioning columns are accommodated in the two positioning holes. The physiological signal monitoring device as claimed in claim 1 , wherein the blocking member is an elastic member. 4 . The physiological signal monitoring device according to claim 1 , wherein the port further comprises a printed circuit board, the printed circuit board comprises a through hole, and the top end of the sensor is accommodated in the through hole.

5. The physiological signal monitoring device as claimed in claim 1, wherein the port further comprises a slot, and a top end of the bracket is lower than the signal output end of the sensor, whereby the signal output end protrudes from the bracket and is accommodated in the slot of the port.

6. The physiological signal monitoring device as claimed in claim 1, wherein the diaphragm elastic member is disposed above the sensor in the implant hole.

7. A support, which carries a sensor to measure a physiological signal of an analyte in a biological fluid, wherein the sensor has a signal detection end and a signal output end, the signal output end is connected to a transmitter and is used to receive the physiological signal, and the support comprises: An implantation hole, which is an implantation channel for implanting the sensor and accommodates a portion of the sensor; A fixing groove, used for fixing the sensor; A waterproof sealing member, which is disposed above the implantation hole to abut against the transmitter to form a waterproof sealing structure; A diaphragm elastic member is disposed in the implant hole to separate the implant hole and cover the cross-sectional area of ​​the implant hole; as well as A barrier is disposed between the implantation hole and the fixing groove to hold the sensor. The bracket according to claim 7 , wherein the barrier member is an elastic member.

9. A bracket as described in claim 7, wherein the diaphragm elastic member is arranged above the sensor in the implantation hole.

Images