Charging device with a positioning device and method for closing a receiver via an exhaust opening

Abstract

The present invention generally relates to a loading device with a positioning device. The present invention particularly relates to a device, a kit, a method for closing a receptacle, the use of an exhaust device, and the use of a positioning device. The present invention relates to a loading device comprising a set of one or more loading cartridges, each loading cartridge having a charge, wherein for each loading cartridge: a. the loading cartridge has an outlet hole and a flexible positioning device at the outlet hole; b. the charge is located within the loading cartridge; c. the loading cartridge is arranged to enable the charge to leave the loading cartridge via the outlet hole.

Description

Field of the Invention

[0001] The present invention generally relates to a loading device having a positioning device. In particular, the present invention relates to a device, a kit, a method for closing a receptacle, the use of an exhaust device, and the use of a positioning device. Background Art

[0002] Drug materials can be provided in various forms and contained in various different containers. In the case of liquid drug materials, some common examples are ampoules, vials, cartridges, and syringes. The sterilization of drug materials is of utmost importance, which in turn depends to a large extent on an appropriate plugging process. Many attempts have been made to provide an automated process that both provides a sterile closed product and increases production. Some of these attempts are based on so-called nesting members that place containers or plugs in a regular array for easy handling.

[0003] An example of an attempt to use a nesting member is WO 2016 166769 A1, in which a nesting member containing closures is aligned on a nesting member containing cartridges in order to transfer the closures to the cartridges.

[0004] German Utility Model Patent DE 20 2017 103 606 U1 discloses the use of an exhaust port in a receptacle of a nesting member to improve the discharge of gas from the receptacle when operating the nesting member in a vacuum.

[0005] U.S. Patent Document US 5 519 984 discloses the use of a tube for temporarily inserting a syringe during plugging.

[0006] There is still a need to provide improved methods and devices for plugging containers filled with drug materials. Summary of the Invention

[0007] Generally, the object of the present invention is to at least partially overcome one or more drawbacks in the prior art, particularly with respect to the closure of receptacles.

[0008] The object of the present invention is to provide a device for closing a receptacle, preferably a drug receptacle, with increased processing throughput.

[0009] The object of the present invention is to provide a device for closing a receptacle, preferably a drug receptacle, by a more convenient method.

[0010] The object of the present invention is to provide a device for closing a receptacle, preferably a drug receptacle, by reduced process steps.

[0011] The object of the present invention is to provide a device for closing a receptacle, preferably a drug receptacle, in a process with a shortened batch cycle.

[0012] The object of the present invention is to provide a device for closing a receptacle, preferably a pharmaceutical receptacle, which reduces the need for equipment, in particular does not require a vacuum device.

[0013] The object of the present invention is to provide a device for closing a receptacle, preferably a pharmaceutical receptacle, at atmospheric pressure.

[0014] The object of the present invention is to provide a device for closing a receptacle, preferably a pharmaceutical receptacle, having an improved purity of the receptacle contents.

[0015] The object of the present invention is to provide a method for closing a receptacle, preferably a pharmaceutical receptacle, having an increased processing throughput.

[0016] The object of the present invention is to provide a more convenient method for closing a receptacle, preferably a pharmaceutical receptacle.

[0017] The object of the present invention is to provide a method for closing a receptacle, preferably a pharmaceutical receptacle, having a reduced number of steps.

[0018] The object of the present invention is to provide a method for closing a receptacle, preferably a pharmaceutical receptacle, having a shortened batch cycle.

[0019] The object of the present invention is to provide a method for closing a receptacle, preferably a pharmaceutical receptacle, which reduces the need for equipment, in particular does not require a vacuum device.

[0020] The object of the present invention is to provide a method for closing a receptacle, preferably a pharmaceutical receptacle, which can be carried out at atmospheric pressure.

[0021] The object of the present invention is to provide a method for closing a receptacle, preferably a pharmaceutical receptacle, having an improved purity of the receptacle contents.

[0022] At least one of the above objects is at least partially solved by the subject matter forming the categories of the claims. The dependent claims represent preferred configurations.

[0023] The following examples are preferred examples of the present disclosure.

[0024] |1| A loading device comprising a set of one or more loading cartridges, each loading cartridge having a charge, wherein for each loading cartridge:

[0025] a. The loading cartridge has an outlet hole and a flexible positioning device at the outlet hole;

[0026] b. The charge is located within the loading cartridge;

[0027] c. The loading cylinder is arranged to enable the load to leave the loading cylinder via the outlet hole.

[0028] |2| The loading device according to embodiment |1|, wherein one or more loading cylinders each have an exhaust device arranged to allow gas to escape from the loading cylinder when the load leaves the loading cylinder through the outlet hole.

[0029] |3| The loading device according to embodiment |2|, wherein for one or more exhaust devices, the exhaust device is a hole. A preferred hole is a groove.

[0030] |4| The loading device according to embodiment |2| or |3|, wherein for one or more loading cylinders, the exhaust device is in the positioning device or in the loading cylinder, preferably in the positioning device. In one aspect of this embodiment, the exhaust device is one or more holes in the positioning device, preferably one or more grooves in the positioning device.

[0031] |5| The loading device according to any one of the foregoing embodiments, wherein one or more loading cylinders comprise a polymer.

[0032] |6| The loading device according to any one of the foregoing embodiments, wherein one or more loading cylinders comprise a member selected from the group consisting of: polypropylene, polyethylene, polyamide, polyoxymethylene, polyvinyl chloride, thermoplastic polyurethane, thermoplastic elastomer, liquid silicone rubber, and polylactate.

[0033] |7| The loading device according to any one of the foregoing embodiments, wherein for one or more loading cylinders, the length of the loading cylinder is not greater than 3 times the length of the load, preferably not greater than 1.5 times, more preferably not greater than 1.2 times. In one aspect of this embodiment, the loading cylinder is elongated, having an elongated extension, and the length of the load is in the direction of the elongated extension of the loading cylinder. In another aspect of this embodiment, the device is configured to enable the load to move in the loading cylinder in the direction of movement, and the length of the load is in the direction of movement.

[0034] |8| The loading device according to any one of the foregoing embodiments, wherein for one or more loading cylinders, the distance from the load to the outlet hole is not greater than 4 times the length of the load, preferably not greater than 2 times, more preferably not greater than 1.5 times. In one aspect of this embodiment, the loading cylinder is elongated, having an elongated extension, and the length of the load is in the direction of the elongated extension of the loading cylinder. In another aspect of this embodiment, the device is configured to enable the load to move in the loading cylinder in the direction of movement, and the length of the load is in the direction of movement.

[0035] |9|The loading device according to any one of the foregoing embodiments, wherein the loading device has more than 3, preferably more than 10, more preferably more than 20, and even more preferably more than 50 loading cylinders.

[0036] |10|The loading device according to any one of the foregoing embodiments, wherein the loading cylinders are held in fixed positions relative to each other.

[0037] |11|The loading device according to any one of the foregoing embodiments, wherein the loading cylinders are parallel to each other. Herein, parallel preferably means that the axes are oriented at an angle of not more than 20°, preferably not more than 5°, and more preferably not more than 3° with respect to each other.

[0038] |12|The loading device according to any one of the foregoing embodiments, wherein the loading cylinders are arranged in a pattern.

[0039] |13|The loading device according to any one of the foregoing embodiments, wherein one or more loadings are selected from the group consisting of a plunger, a stopper, a seal, and a sealing cap, preferably a plunger.

[0040] |14|The loading device according to any one of the foregoing embodiments, wherein for one or more loading cylinders, the inner diameter of the loading cylinder at the outlet hole is smaller than the inner diameter of the loading cylinder at a point within the loading cylinder.

[0041] |15|The loading device according to any one of the foregoing embodiments, wherein the closest distance between the first loading cylinder and the second loading cylinder is greater than one-eighth of the radius of the first loading cylinder, preferably greater than one-fourth of the radius of the first loading cylinder, and more preferably greater than half of the radius of the first loading cylinder.

[0042] |16|The loading device according to any one of the foregoing embodiments, wherein the closest distance between the first loading cylinder and the second loading cylinder is in the range of 3 to 8 mm, preferably in the range of 4 to 7 mm, and more preferably in the range of 5 to 6 mm.

[0043] |17|The loading device according to any one of the foregoing embodiments, wherein the closest distance between the first loading cylinder and the second loading cylinder is not greater than 8 mm, preferably not greater than 7 mm, and more preferably not greater than 6 mm.

[0044] |18|The loading device according to any one of the foregoing embodiments, wherein the closest distance between the first loading cylinder and the second loading cylinder is not less than 3 mm, preferably not less than 4 mm, and more preferably not less than 5 mm.

[0045] |19|The loading device according to any one of the foregoing embodiments, wherein the loading device is located within a sterile container. Preferred containers are drums, boxes, sachets and bags, or combinations of two or more thereof.

[0046] |20|The loading device according to any one of the foregoing embodiments, wherein one or more of the loadings comprise a material having a Young's modulus less than that of the loading cylinder.

[0047] |21|The loading device according to any one of the foregoing embodiments, wherein one or more of the loadings comprise a thermoplastic elastomer. The thermoplastic elastomer preferably comprises butyl or halogen or both. In the present context, preferred halogens are fluorine, chlorine and bromine.

[0048] |22|A kit comprising a loading device according to any one of the foregoing embodiments and a receiving device, the receiving device comprising one or more receiving cylinders, each receiving cylinder having a receiver therein;

[0049] wherein each receiver has an inlet hole;

[0050] wherein each receiver is adapted to receive a loading from the loading cylinder through its inlet hole.

[0051] |23|The kit according to embodiment |22|, wherein the positioning device of the first loading cylinder is complementary to the inlet hole of the first receiver.

[0052] |24|The kit according to embodiment |22| or |23|, wherein one or more of a group of receivers are selected from the group consisting of: cartridges, syringes, syringe precursors and vials.

[0053] |25|The kit according to any one of |22| to |24|, wherein one or more of the receiving cylinders comprise a polymer.

[0054] |26|The kit according to any one of |22| to |25|, wherein one or more of the receiving cylinders comprise one or more selected from the group consisting of: polypropylene, polyethylene, polyamide, polyoxymethylene, polyvinyl chloride, thermoplastic polyurethane, thermoplastic elastomer, liquid silicone rubber and polylactate.

[0055] |27|The kit according to any one of |22| to |26|, wherein the first loading is a closure for the first receiver.

[0056] |28|The kit according to any one of |22| to |27|, wherein the loading cylinders and the receiving cylinders are in one-to-one correspondence.

[0057] |29|A kit according to any one of embodiments |22| to |28|, wherein the charging cylinder is arranged in a pattern form and the receiving cylinder is arranged in a complementary pattern.

[0058] |30|A kit according to any one of embodiments |22| to |29|, wherein the charging cylinders are held in fixed positions relative to each other.

[0059] |31|A kit according to any one of embodiments |22| to |30|, wherein the receiving cylinders are parallel to each other. Herein, parallel preferably means that the axes are oriented at an angle of not more than 20°, preferably not more than 5°, more preferably not more than 3° to each other.

[0060] |32|A kit according to any one of embodiments |22| to |31|, wherein the receiving cylinders are arranged in a pattern form.

[0061] |33|A kit according to any one of embodiments |22| to |32|, wherein the receiving device is located inside a sterile container. Preferred containers are buckets, boxes, sachets and bags, or combinations of two or more thereof.

[0062] |34|A method for preparing one or more closed receivers, comprising the following process steps:

[0063] a. Providing a kit according to any one of embodiments |22| to |33|,

[0064] b. Discharging one or more charges from the charging cylinder through the outlet holes of the charging cylinder into the corresponding receiver via the inlet holes of the corresponding receiver.

[0065] |35|The method according to embodiment |34|, wherein the pressure inside one or more receivers before step b., preferably the pressure in all receivers before step b., is at least 10 4 Pa, preferably at least 5×10 4 Pa, more preferably at least 9×10 4 Pa. In one aspect of this embodiment, the method is carried out at atmospheric pressure. In one aspect of this embodiment, the method is carried out above atmospheric pressure. In one aspect of this embodiment, the method is carried out at about 10 5 Pa. In one aspect of this embodiment, the method is carried out at more than 10 5 Pa.

[0066] |36|The method according to embodiment |34| or |35|, wherein the discharge in step b. is affected by a pressurized gas. The gas temperature during discharge is preferably below 200 °C.

[0067] |37|A method according to any one of embodiments |34| to |36|, wherein a material is introduced into one or more receivers between step a. and step b. The material is preferably a liquid. The material is preferably a drug. The material preferably contains an active pharmaceutical ingredient.

[0068] |38|In an alternative embodiment, a material is typically introduced into one or more receivers at some point during the process. The material is preferably a liquid. The material is preferably a drug. The material preferably contains an active pharmaceutical ingredient.

[0069] |39|Use of a cartridge with an exhaust device during the process of plugging with a stopper at a pressure of at least 10 4 Pa, preferably at least 5×10 4 Pa, preferably at least 9×10 4 Pa. In one aspect of this embodiment, the process is carried out at atmospheric pressure. In one aspect of this embodiment, the process is carried out above atmospheric pressure. In one aspect of this embodiment, the process is carried out at about 10 5 Pa. In one aspect of this embodiment, the process is carried out above 10 5 Pa.

[0070] |40|Use of a cartridge with a venting device in the production of a closed receiver.

[0071] |41|Use according to embodiment |40|, wherein the closed receiver is a cartridge, a syringe, a syringe precursor or a vial.

[0072] |42|Use according to embodiment |40| or |41|, wherein the closed receiver contains a pharmaceutical active ingredient.

[0073] Throughout this disclosure, the term "parallel" preferably refers to an angle of not more than 20°, preferably not more than 5°, more preferably not more than 3°.

[0074] In this document, atmospheric pressure is 101,325 Pa.

[0075] This disclosure relates in various places to one or more of a charge, a charge cartridge, a receiver, a receiver cartridge, an ejection device, a positioning device and other components of a device or kit. In each case, preferably at least 10, preferably at least 20, more preferably at least 50.

[0076] Loading device

[0077] A preferred charging device is configured to be suitable for applying a charge to a receiver to preferably close the receiver.

[0078] The loading device according to the present invention includes one or more loading cylinders, each loading cylinder having loading and positioning means. Preferably, each loading cylinder has exhaust means.

[0079] The loading cylinders are preferably in fixed positions relative to each other.

[0080] The loading device may include a loading support. The preferred loading support is configured to fix the loading cylinders relative to each other in a fixed position, preferably in a certain pattern. The loading cylinders are preferably arranged in a pattern. The outlet holes of the loading cylinders are preferably arranged in a pattern. The pattern can be a conventional pattern or an unconventional pattern. The preferred pattern is part of a regular lattice. The preferred regular lattices are hexagonal lattices and square lattices.

[0081] In one embodiment, the loading device includes a loading support, and the loading cylinders and the loading support are integral members. In one aspect of this embodiment, the loading device and the loading support are molded plastic parts.

[0082] In one embodiment, the loading device includes a loading support, and the loading cylinders and the loading support comprise the same material, preferably made of the same material.

[0083] The maximum spatial extent of the loading device is preferably in the range of 10 to 50 cm, preferably in the range of 20 to 40 cm.

[0084] Loading cylinder

[0085] The loading device according to the present invention includes a group of one or more loading cylinders, each loading cylinder having an outlet hole.

[0086] The preferred loading cylinder is elongated.

[0087] The preferred loading cylinder is hollow, preferably having an orifice at the end. In one embodiment, the loading cylinder has an orifice at each of the two ends. The preferred orifice is an outlet hole for discharging the loading from the loading cylinder. Another preferred orifice is configured to allow the injection device to act on the loading located in the loading cylinder.

[0088] The preferred loading cylinder is arranged to accommodate the loading. Preferably, the accommodated loading is held in the loading cylinder, preferably held in the loading cylinder by elastic contact with the inner surface of the loading cylinder. The preferred loading cylinder is configured to preferably eject the loading via the outlet hole. In this case, the ejection is preferably carried out by an ejection device.

[0089] The loading cylinders preferably preload the loading respectively.

[0090] In a preferred embodiment, more than two of the loading barrels are parallel to each other, and preferably all the loading barrels are parallel to each other. The preferred arrangement of the loading barrels is a group of parallel loading barrels.

[0091] In a preferred embodiment, more than two of the loading barrels in the assembly are configured to eject the loading in a parallel direction. Preferably, all the loading barrels are configured to eject the loading in a parallel direction. Herein, "parallel" preferably means that the axes are oriented at an angle not greater than 20°, preferably not greater than 5°, and more preferably not greater than 3° with respect to each other.

[0092] The preferred loading barrel may include one or more holding means for holding the loading. The preferred holding means is one or more selected from the group consisting of: protrusions, recesses, and constrictions. In one embodiment, the loading barrel has a holding means for ensuring that the loading does not fall from the top end of the loading barrel. In one embodiment, the loading barrel has a holding means for ensuring that the loading does not fall from the bottom end of the loading barrel. In one embodiment, the loading barrel has a holding means for ensuring that the loading does not fall from the top end of the loading barrel and a holding means for ensuring that the loading does not fall from the bottom end of the loading barrel.

[0093] In one embodiment, the loading barrel has one or more protrusions, which preferably protrude from the inner surface of the loading barrel. The preferred protrusions are adapted to hold the loading in the loading barrel. Preferably, the protrusions in the loading barrel are complementary to the recesses in the loading.

[0094] In one embodiment, the loading barrel has one or more recesses, preferably on the inner surface of the loading barrel. The preferred recesses are suitable for holding the loading in the loading barrel. Preferably, the recesses in the loading barrel are complementary to the protrusions in the loading.

[0095] In one embodiment, the positioning means is located at the end of the loading barrel, where the inner diameter of the loading barrel at this end is smaller than the inner diameter of the loading barrel outside this end.

[0096] The inner diameter of the loading barrel is preferably in the range of 5 mm to 20 mm, more preferably in the range of 8 mm to 15 mm, and even more preferably in the range of 9 mm to 12 mm.

[0097] Loading

[0098] The preferred loading is configured to close the receptor preferably by elastic contact with the inner surface of the receptor.

[0099] The preferred loading includes an elastic material. The elastic material is preferably adapted to seal the receptor by preferably elastic contact.

[0100] In this case, the preferred material is a thermoplastic elastomer.

[0101] The preferred thermoplastic elastomer contains butyl.

[0102] The preferred thermoplastic elastomer includes a halogen, preferably selected from one or more of fluorine, chlorine, and bromine.

[0103] The preferred charge is a stopper and a plunger.

[0104] In one embodiment, the charge is a plunger head, preferably for a syringe.

[0105] The charge may include one or more selected from the group consisting of protrusions and recesses. The preferred protrusion is complementary to the recess in the charge barrel, preferably for holding the charge in the charge barrel. The preferred recess is complementary to the protrusion in the charge barrel, preferably for holding the charge in the charge barrel. The preferred protrusion is a circumferential protrusion. The preferred recess is a circumferential recess.

[0106] The diameter of the charge is preferably in the range of 5 mm to 20 mm, more preferably in the range of 8 mm to 15 mm, and even more preferably in the range of 9 mm to 12 mm.

[0107] Positioning device

[0108] The charge barrel according to the present invention has a positioning device. The positioning device is preferably configured to position the charge barrel relative to the receiving barrel, preferably such that the charge exiting the charge barrel can enter the receiving barrel, thereby preferably closing the receiver.

[0109] The positioning device and the charge barrel can be integrated with each other, attached, welded, adhered, or a combination thereof.

[0110] In one embodiment, the charge barrel and the positioning device are made of the same material. In another embodiment, the charge barrel and the positioning device are made of different materials. In one aspect of this embodiment, the positioning device has a lower Young's modulus than the charge barrel. In one aspect of this embodiment, the positioning device has a lower Shore hardness than the charge barrel.

[0111] In one embodiment, the charge has a lower Young's modulus than the positioning device. In one embodiment, the charge has a lower Shore hardness than the positioning device.

[0112] In one embodiment, the Shore A hardness of the charge is in the range of 30 to 80, preferably in the range of 35 to 70, and more preferably in the range of 40 to 60.

[0113] In one embodiment, the Shore A hardness of the positioning device is at least 30, preferably at least 60, more preferably at least 80. In one embodiment, the Shore A hardness of the positioning device is not greater than 90, preferably not greater than 80, more preferably not greater than 70. In one embodiment, the Shore D hardness of the positioning device is in the range of 20 to 90, preferably in the range of 30 to 80, more preferably in the range of 40 to 70.

[0114] In one embodiment, the Shore hardness of the charge is less than that of the positioning device. Preferably, the Shore hardness of the charge is at least 1 less than, more preferably at least 10 less than, that of the positioning device. Preferably, the Shore A hardness of the charge is less than that of the positioning device. Preferably, the Shore A hardness of the charge is at least 1 less than, more preferably at least 10 less than, that of the positioning device. Preferably, the Shore D hardness of the charge is less than that of the positioning device. Preferably, the Shore D hardness of the charge is at least 1 less than, more preferably at least 10 less than, that of the positioning device.

[0115] A preferred positioning device is the narrowed portion of the charging cylinder. The inner diameter of the positioning device is preferably less than that of the charging cylinder. In one embodiment, the inner diameter of the positioning device is 1 mm to 4 mm less than that of the charging cylinder, preferably 1.25 mm to 3 mm less, more preferably 1.5 mm to 2.5 mm less.

[0116] The positioning device is preferably flexible.

[0117] The preferred positioning device is configured to be introduced into a recipient.

[0118] The preferred positioning device is configured to be introduced into a recipient cylinder.

[0119] The preferred positioning device forms an extension of the charging cylinder.

[0120] In one embodiment, the positioning device is based on a hollow cylinder or a hollow prism, preferably a hollow cylinder. The positioning device can be an incomplete hollow prism or cylinder, preferably having one or more holes in the side wall. The positioning device preferably has an inner diameter less than that of the charging cylinder. The positioning device preferably has an inner diameter less than that of the recipient. The positioning device preferably has an inner diameter less than that of the recipient cylinder. The positioning device preferably has an outer diameter less than that of the charging cylinder. The positioning device preferably has an outer diameter less than that of the recipient. The positioning device preferably has an outer diameter less than that of the recipient cylinder.

[0121] The preferred positioning device is a partial peripheral wall. The preferred peripheral wall constitutes 30% to 70%, preferably 40% to 60%, of the entire peripheral wall.

[0122] The preferred positioning device is a peripheral wall having one or more selected from the group consisting of holes, grooves, and gaps.

[0123] The preferred positioning device includes more than two local components, preferably 2, 3, 4, 5 or 6, and more preferably 3.

[0124] In one embodiment, one or more of the local components have an axial groove, the circumferential extent of which is less than one third, preferably less than one quarter, of the circumferential extent of the local component.

[0125] The positioning device can be tapered. Taper can assist in inserting the positioning device into a receptacle and / or discharging the charge from the positioning device.

[0126] In one embodiment, the positioning device has a tapered portion, the thickest end of which faces the charge cylinder.

[0127] In one embodiment, the positioning device preferably has a circumferential recess on its outer surface. The circumferential recess is preferably in the upper half of the positioning device.

[0128] In one embodiment, the positioning device has a chamfered lower end. The chamfer is preferably on the outer surface of the positioning device.

[0129] Exhaust device

[0130] The device according to the invention includes an exhaust device. The preferred exhaust device is configured to allow gas to escape from the charge cylinder. The preferred exhaust device is configured to allow gas pressurized by the charge leaving the charge cylinder to escape.

[0131] The preferred exhaust device is a hole or a groove. The preferred hole or groove provides a passage between the interior and the exterior of the charge cylinder. The preferred exhaust device is located in the charge cylinder. Another preferred exhaust device is located in the positioning device.

[0132] Receiving device

[0133] The preferred receiving device is configured to receive the charge in a receptacle to preferably enclose the receptacle.

[0134] The receiving device according to the invention includes one or more receptacle cylinders, each receptacle cylinder having a receptacle.

[0135] The receptacle cylinders are preferably in fixed positions relative to each other. The receptacles are preferably in fixed positions relative to each other.

[0136] The receiving device can include a receptacle support. The preferred receptacle support is configured to hold the receptacles in position relative to each other.

[0137] In one embodiment, the receiving device includes a receptor support, and the receptor barrel and the receptor support are integral members. In one aspect of this embodiment, the receiving device and the receptor support are molded plastic parts.

[0138] In one embodiment, the receiving device includes a receptor support, and the receptor barrel and the receptor support comprise the same material, preferably made of the same material.

[0139] In one embodiment, the receptor is slidably inserted into the receptor barrel. In one embodiment, the receptor can be slidably removed from the receptor barrel.

[0140] International Patent Document WO 2016 / 166769 A1 discloses a receiving device in Figure 1 Figures 1 to 9 and the accompanying description, which is incorporated herein by reference.

[0141] Receiver cylinder

[0142] The receiving device according to the present invention includes a set of one or more receptor barrels, each receptor barrel having a receptor therein.

[0143] The preferred receptor barrel is elongate.

[0144] The preferred receptor barrel is hollow, preferably having an orifice at one end, more preferably having orifices at each of the two ends. The preferred orifice is an inlet hole for allowing the charge to enter the receptor barrel.

[0145] The preferred receptor barrels are arranged to be adapted to receive the receptors. The received receptors are preferably held in the receptor barrels, preferably held in the receptor barrels by abutment. In one embodiment, the receptor abuts against the upper surface of the receptor barrel. The abutment can be at the top of the receptor or at the bottom of the receptor. The preferred receptor barrels are configured to be adapted to receive the charge preferably via the inlet holes. In this context, the receiving preferably is accompanied by the closing of the receptor, preferably closing the inlet hole of the receptor.

[0146] The receptor barrels are preferably pre-loaded with receptors.

[0147] In a preferred embodiment, more than two of the set of receptor barrels are parallel to each other, preferably all the receptor barrels are parallel to each other. The preferred arrangement of the receptor barrels is a set of parallel receptor barrels.

[0148] In a preferred embodiment, two or more of the set of receptor barrels are configured to eject the charge in a parallel direction, preferably all of the receptor barrels are arranged to eject the charge in a parallel direction. In this context, parallel preferably means that the axes are oriented at an angle of no more than 20°, preferably no more than 5°, more preferably no more than 3° to each other.

[0149] In one embodiment, the receptor barrel has retaining means for holding the receptor in a fixed position. Preferred retaining means are lips, protrusions, recesses and flanges. The preferred retaining means are configured to be complementary to the receptor, preferably a lip, protrusion, recess or flange or receiving portion.

[0150] The inner diameter of the receptor barrel is preferably in the range of 5 mm to 20 mm, more preferably in the range of 8 mm to 15 mm, even more preferably in the range of 9 mm to 12 mm.

[0151] Receiver

[0152] The preferred receptor is configured to accommodate a material, preferably a liquid, preferably a pharmaceutical product. The preferred receptor is a pharmaceutical receptor.

[0153] The preferred receptor is elongated. The preferred shape of the receptor is a cylinder or a prism, preferably a cylinder.

[0154] The preferred receptor has an interior. A preferred receptor has one or more receptor walls. A preferred receptor has one or more receptor holes.

[0155] In one embodiment, the receptor is elongated and has an orifice only at one end. In another embodiment, the receptor is elongated and has an orifice at each of the two ends.

[0156] The closure of the receptor is preferably the closure of the receptor hole. In one case, the closure of the receptor is the closure of the only receptor hole. In another case, the closure of the receptor is the closure of one of the two open receptor holes. In another case, the closure of the receptor is the closure of the only open receptor hole, and the receptor also has a receptor hole that has been closed.

[0157] The preferred receptor corresponds to the charge. The preferred receptor is suitable for receiving the charge. The preferred receptor is adapted to be closed by the charge.

[0158] The preferred receptor is complementary to the receptor barrel. The preferred receptor is adapted to be introduced into the receptor barrel. The preferred receptor is adapted to be removed from the receptor barrel. The preferred receptor has a mating part for positioning it in the receptor barrel. The preferred mating part is a protrusion or a recess. A preferred protrusion is a flange. In this context, the preferred mating part is adapted to abut or snap elastically.

[0159] In one embodiment, the receptor is a syringe precursor. The preferred syringe precursor has two holes. The first hole is an inlet hole for receiving the charge. The charge is preferably a plunger or a plunger head. The second hole is an ejection hole configured to be adapted to attach to a needle. Preferably, during the process according to the invention, the second hole is closed.

[0160] The preferred receptor is adapted to be held by the receptor barrel. The preferred receptor may have a recess or a protrusion.

[0161] A receptor is disclosed in FIGS. 6a and 6b and the accompanying description of the international patent document WO2016 / 166769A1, which is incorporated herein by reference.

[0162] Kit / device

[0163] The charging device according to the invention and the receiving device according to the invention are preferably used in combination, preferably as components of a device or as components of a kit, most preferably as components of a kit.

[0164] As a kit, the charging device and the receiving device can be aligned or engaged with each other, or both.

[0165] Sterile housing

[0166] The charging device according to the invention or the kit according to the invention can be provided in a sterile housing. A sterile housing is disclosed in FIG. 9 and the accompanying description of the international patent document WO2016 / 166769A1, which is incorporated herein by reference.

[0167] Method

[0168] The present disclosure provides a method for closing one or more receptors. The preferred method is to close more than 2, preferably more than 10, more preferably more than 20, and even more preferably more than 50 receptors simultaneously.

[0169] In the case of a kit according to the present disclosure, the charge of the charging device is ejected from the charging barrel into the receptor of the receiving device. The charging device according to the invention can also be used to close receptors that are not from the kit, but are otherwise arranged in a position complementary to the position of the charging barrel of the charging device.

[0170] The receiver is preferably filled before being closed. The filling preferably closes the only hole or the only remaining open hole of the receiver, one or more other holes of the receiver having been closed before filling.

[0171] In the method according to the invention, the filling preferably leaves the positioning device at least partially. In one embodiment, the filling only partially leaves the positioning device. According to this embodiment, preferably, the degree to which the filling leaves is such that the coefficient of friction between the filling and the inner surface of the receiver is greater than the coefficient of friction between the filling and the positioning device. In one embodiment, the filling completely leaves the positioning device. In one aspect of this embodiment, the filling moves to a position where its top is less than 4 mm, preferably less than 3 mm, more preferably less than 2 mm below the bottom end of the positioning device. In another aspect of this embodiment, the filling moves to a position where its top is more than 4 mm, preferably more than 5 mm, more preferably more than 6 mm below the bottom end of the positioning device. Preferably, the filling completely leaves the positioning device.

[0172] Injection device

[0173] The preferred ejection device is configured to be suitable for ejecting the filling from the filling cylinder. The preferred ejection device may be located at the orifice of the filling cylinder, preferably at an orifice other than the outlet hole.

[0174] In one embodiment, the ejection device is configured to be suitable for ejecting the filling by means of compressed gas. The pressure of the compressed gas is greater than the ambient pressure. The preferred pressure of the compressed gas is at least 2·10 5 Pa, preferably at least 3·10 5 Pa, most preferably at least 4·10 5 Pa. In another embodiment, the ejection device is configured to be suitable for ejecting the filling by mechanical pushing (such as a movable pin).

[0175] Testing method

[0176] Shore hardness

[0177] Shore A and Shore D are determined according to ISO 7619-1. BRIEF DESCRIPTION OF THE DRAWINGS

[0178] The following drawings are used to further explain the present disclosure. These figures are exemplary and do not limit the scope of the present invention

[0179] of the present invention.

[0180] Figure 1 A flowchart of the method according to the present invention is shown.

[0181] Figure 2a A perspective view seen from the side above of the filling device 2 is shown.

[0182] Figure 2b The positioning device is shown in perspective from below.

[0183] Figure 2c The loading of the loading device is shown in perspective from above.

[0184] Figure 2d The positioning device is shown in perspective from below.

[0185] Figure 3a The loading device in place is shown in perspective from above, with the positioning device assembled in the receptacle.

[0186] Figure 3b The loading device in position is shown in cross-section from the side, with the positioning device assembled in the receptacle.

[0187] Figure 4a A cross-sectional view is shown of the loading device in place as seen from the side during loading injection.

[0188] Figure 4b An enlarged cross-sectional view is shown of the loading device in place as seen from the side during loading injection. DETAILED DESCRIPTION

[0189] Figure 1 A flow chart of the method according to the invention is shown. In a first step P1, a loading device 2 and a receiving device 1 according to the invention are provided. For example, this can include providing a kit containing the loading device 2 and the receiving device 1. In a second step P2, the receptacle 5 of the receiving device 1 is filled, for example, with a liquid containing a pharmaceutically active ingredient. In a third step P3, the loading device 2 and the receiving device 1 are positioned relative to each other by introducing the positioning device 64 of the loading cylinder 63 into the respective receptacle 5. In a fourth step P4, the load 200 is injected from the loading cylinder 63 into the receptacle 5 to close it.

[0190] Figure 2aA perspective view is shown looking from above and to the side of the loading device 2. The device 2 has 100 loading cartridges 63, which are arranged in a hexagonal grid and held in place by a layered loading support 60. The loading support 60 has a rectangular shape with curved corners 62. In this case, the loading cartridges 63 and the loading support 60 are an integral part made of molded plastic. Each loading cartridge 63 has an interior 61, which is adapted and sized to receive a charge 200 (a charge not present in the figure). In this case, each loading cartridge 63 has a protrusion 63a in its interior 61, which serves as a holding device for the charge 200 and holds it by preventing its upward movement. Each loading cartridge 63 has a positioning device 64 at its lower end. In this case, the loading cartridges 63 do not extend above the plane of the loading support 60, but only below it. In an alternative, the loading cartridges 63 may extend above the plane of the loading support 60.

[0191] Figure 2b The positioning device 64 is shown in perspective looking from below and to the side. The positioning device 64 is located at the bottom edge 63b of the loading cartridge 63, which is held in place by the loading support 60. In this case, the loading cartridge 63 narrows towards its lower edge 63b such that the inner surface presents an inward taper 63c. The inward taper 63c forming the constriction of the loading cartridge 63 can serve as a holding device for the charge 200 by resisting the downward movement of the charge 200. The positioning device 64 and the loading cartridge 63 can together form a single integral part, or alternatively, the positioning device 64 can be connected or connectable to the loading cartridge 63. In this case, the positioning device 64 consists of 3 parts, which together form an extension of the side wall of the loading cartridge 63. The three extensions together approximately form 50% of the circumferential wall. The gaps between the 3 parts form 3 main gaps 66 in the positioning device 64, which serve as an exhaust device for allowing gas to move from the interior of the positioning device 64 to the exterior. When gas is exhausted from the loading cartridge 63, this exhaust allows the gas to vent in front of the charge 200 (not the position in the figure). The positioning device 64 is followed immediately after its top end 64f by a circumferential recess 65, where the positioning device 64 meets the loading cartridge 63. The circumferential recess 65 promotes air flow and the flexing of the positioning device 64. The positioning device 64 has its thickest point 64e below the circumferential recess 65, after which it tapers towards its lower end 64c. The outer surface of the positioning device 64 is chamfered 64d inwards at its lower end 64c. The lower end 64c of the positioning device 64 is open and in this case forms a circular outlet hole 300. Both the tapering and the chamfering contribute to positioning the positioning device 64 within a receiver 5 (not shown). In this case, the inner surface 64a of the positioning device 64 has a cylindrical shape and the variation in thickness is manifested on the outer surface 64b.

[0192] Figure 2cThe loading of the loading device 2 is shown in perspective from above. The loading device 2 has 100 loading cylinders 63, which are held by a loading support 60 in a regular array, in this case a rectangle with rounded corners 62. 100 loadings 200 are located above the array of 100 loading cylinders 63, ready to be introduced into their interior 61.

[0193] Figure 2d The positioning device 64 is shown in perspective from below. Like the Figure 2b positioning device, this positioning device 64 has three parts that form an extension of the cylindrical wall of the loading cylinder 63. Similarly, the loading cylinder 63 is held in place by the loading support 60, and the positioning device 64 is connected to the bottom edge 63b of the loading cylinder 63. The lower end 64c of the positioning device 64 is open and, in this case, forms a circular outlet hole 300. The positioning device 64 has a circumferential recess 65 from the top 64f to the bottom 64c, followed by a vertex 64e, an inwardly tapering outer surface 64b, and an inwardly beveled end 64d. The inner surface 64a of the positioning device again tapers inwardly so as to contract towards its lower end 64d and serves as a holding device for the loading 200. In this case, each part has a smaller axial groove 67 that extends into the circumferential recess 65, such that the exhaust device consists of the main gap 66 between the parts of the positioning device 64 and the smaller axial grooves 67 present in this part. The axial grooves 67 improve the flexure of the component as well as the exhaust. For evacuation, the gas can pass through the axial grooves 67 and then travel along the circumferential recess 65 to reach the environment.

[0194] Figure 3a The loading device 2 in place is shown in perspective from the upper side, where the positioning device 64 is assembled in the receptacle 5. The receptacle 5 is located in the receptacle cylinder 12, and the receptacle cylinder 12, together with the other receptacle cylinders of the receiving device 1, is held in place by a receptacle support 10. In this case, the receptacle 5 rests on a base (not shown) located at the bottom of the receptacle cylinder 12. The loading cylinders 63, together with the other loading cylinders of the loading device 2, are held in place by the loading support 60. The positioning device 64 has been inserted into the receptacle 5. The entire positioning device 64, except for a small part at its top end, is positioned within the receptacle 5. The top of the positioning device 64 is prevented from entering the receptacle cylinder 12 because the radius of its top is greater than the inner diameter of the receptacle 5. The accessible passage 69 formed by the top of the main gap in the positioning device 66 remains above the top of the receptacle, thus allowing the gas to be evacuated directly or through the circumferential recess in the positioning device 65 from inside the positioning device 64. Arrow P shows that, in this action, the pressurized gas serves as an ejection device to eject the loading 200 (not shown) from the loading cylinder 63 through the positioning device 64 into the receptacle 5.

[0195] Figure 3bThe charging device 2 in place is shown in a sectional view from the side, where the positioning device 64 is assembled in the receptacle 5. The charging cylinder 63 is held in place by the charging support 60. In this case, the charging cylinder 63 and the positioning device 64 are formed as an integral member. The receptacle 5 is located in the receptacle cylinder 12. The receptacle cylinder 12 of the receiving device 1 is held in place by the receptacle support 10. The positioning device 64 is located inside the receptacle 5, and its outer wall 64a contacts the inner wall of the receptacle wall 50. The positioning device 64 has entered the receptacle 5 through the upper access hole 53. The top end of the positioning device 64 is held outside the receptacle 5, and the gap Δz provides an accessible passage 69 for exhausting air from inside the positioning device 64. The charge 200 inside the charging cylinder 63 is held in place from above by the protrusion 63a on the inner wall of the charging cylinder 63 and from below by the inward taper 63c towards the bottom edge 63b of the charging cylinder 63. The protrusion 63a serves as a holding device for the charge 200 by resisting the upward movement of the charge 200, and the inward taper 63c forms a constriction and serves as a holding device for the charge 200 by resisting the downward movement of the charge 200. The charge has circumferential protrusions 201 and recesses 202 in its radius to assist in holding it in place, and thus can serve as a protrusion and recess type of fixing device incorporated into the charge. Pressurized gas P can be applied to the top of the charge 200 to push it downward, so that it is discharged from the charging cylinder 63 into the receptacle 5 through the positioning device 64.

[0196] Figure 4a A sectional view is shown looking at the side of the charging cylinder 63 in place during the ejection of the charge 200. The arrow P represents the pressurized gas from the ejection device 121 for pushing the charge 200 downward out of the charging cylinder 63 and through the positioning device 64 into the receptacle 5 located in the receptacle cylinder 12. The shoulder 401 towards the bottom of the receptacle 5 and the inward protrusion 402 of the receptacle cylinder 12 serve as mating parts for positioning the receptacle 5. By abutting the shoulder 401 against the protrusion 402, the receptacle 5 is rested on the receptacle cylinder 12. The charge is held inside the charging cylinder 63 by the protrusion 63a in the charging cylinder 63 from above, and the protrusion 63a serves as a holding device for the charge 200 by resisting the upward movement of the charge 200. The ejection device 121 applies sufficient force to push the charge 200 through the constriction at the lower end 63c of the charging cylinder 63 by radial compression of the charge 200, and the constriction forms a constriction and serves as a holding device for the charge 200. In this figure, most of the charge 200 has been pushed out of the charging cylinder, and its bottom end has reached the bottom end of the positioning device 64. The inner radius of the positioning device 64 is smaller than the inner radii of the charging cylinder 63 and the charge 200, and the charge 200 is radially compressed by the inner wall of the positioning device 64. Once the charge 200 leaves the positioning device 64, it expands to make a sealing contact with the inner wall of the receptacle 5.

[0197] Figure 4b Shows an enlarged cross-sectional view taken from the side of the loading device 2 in its proper position during injection of the charge 200 from the interior 61 of the loading cylinder 63 into the receptacle 5. The downward direction is defined by the loading support 60, shown as a horizontal thin plate. The charge 200 moves downward from a position held above by the projection 63a in the loading cylinder 63 and below by the narrowing 63c of the loading cylinder 63c. The projection 63a serves as a holding device for the charge 200 by resisting the upward movement of the charge 200, and the narrowing 63c constitutes a constriction and serves as a holding device for the charge by resisting the downward movement of the charge 200. The charge 200 has partially passed through the narrowing 63c of the loading cylinder 63 and passed through a stationary point at which the inward recess 202 of the charge 200 corresponds to the narrowing 63c at the lower end of the loading cylinder 63. It can be seen that the positioning device 64 flexes inwardly by pivoting about the contact point between its thickest point and the inner surface of the receptacle wall 50. This reduces the inner surface 64a of the positioning device 64 from top to bottom. An accessible channel 69 is shown at the top of the receptacle 5, where the clearance between the positioning device and the top of the receptacle 5 is the difference Δz. The air pushed by the charge 200 as it travels downward can escape through the accessible channel 69.

[0198] Example

[0199] The following examples are for further explanation of the present disclosure. They are exemplary and do not limit the scope of the invention.

[0200] Example 1

[0201] According to Figure 2a , a nest of 100 plugs (charges) is provided. The plugs are made of a silicone-based polymer with a Shore A hardness of 30. The loading cylinder and the loading support are made of polypropylene with a Shore D hardness of 70. The plugs are made of polyisobutylene. The loading cylinder has a positioning device according to Figure 2b . The positioning device is made of a silicone-based polymer with a Shore A hardness of 35. A nest for accommodating 100 pre-crimped syringe barrels is provided, and the pattern of the syringe barrels is complementary to the pattern of the loading cylinder. The syringe barrels are filled with water, and there is a 1.1 cm air gap left at the top of each barrel. By introducing the positioning device into the top hole of the syringe barrel, the nest of plugs is positioned corresponding to the nest of syringe barrels. By pressing from above with an electric rod, the plugs are ejected from the loading cylinder into the syringe barrels. The plugs are introduced into the receptacle while the positioning device is removed from the syringe barrels. Thus, the syringe barrels are closed. This example is repeated 100 times at atmospheric pressure.

[0202] Example 2

[0203] Repeat Example 1, replacing the material of the loading device (loading cylinder, loading support, and positioning device) with polypropylene having a Shore D hardness of 70, and replacing the material of the plug with bromobutyl rubber having a Shore A hardness of 70.

[0204] Examples 3 and 4

[0205] Repeat Examples 1 and 2, except that there is no main gap 66 in the positioning device 64.

[0206] Examples 5 to 8

[0207] Repeat Examples 1 to 4, except that it is carried out at a pressure of 100 Pa in the vacuum chamber.

[0208] Examples 9 to 16

[0209] Repeat Examples 1 to 8, except that there is no positioning device.

[0210] Examples 17 to 24

[0211] Repeat Examples 1 to 8, except that it has a positioning device according to Figure 2d .

[0212] Result

[0213] Considering the following meanings of the performance parameters, the results provided in the following table were obtained: - = unfavorable, --- = very unfavorable, + = favorable, ++ = very favorable, +++ = most favorable, NA = not applicable.

[0214]

[0215] As can be seen from the results, the positioning device allows the plugging action with the plug to be carried out at atmospheric pressure. In the absence of the positioning device, the pressure established in the syringe barrel causes overflow and damage to the syringe barrel. The positioning device also allows the loading nest to be made of a softer material. This increases the purity of the product because it avoids dust generated due to mechanical wear. By providing exhaust grooves in the positioning device, the accumulation of pressure is avoided and the success rate of plugging is improved. The additional grooves in the local components of the positioning device (according to Figure 2d ) improve the ease of insertion and reduce the required force.

[0216] List of reference signs

[0217] P1 provides the step

[0218] P2 filling step

[0219] P3 positioning step

[0220] P4 closing step

[0221] 1 Receiving device

[0222] 2 Loading device

[0223] 5 Receiver

[0224] 10 Receiver support

[0225] 12 Receiver cylinder

[0226] 50 Receiver wall

[0227] 53 Receiver entry hole

[0228] 60 Loading support

[0229] 61 Inside of loading cylinder

[0230] 62 Rounded corner of loading support

[0231] 63 Loading cylinder

[0232] 63a Protrusion of loading cylinder (holding device)

[0233] 63b Bottom edge of loading cylinder

[0234] 63c Inner taper of side wall (holding device)

[0235] 64 Positioning device

[0236] 64a Inner surface of positioning device

[0237] 64b Outer surface of positioning device

[0238] 64c Lower end of positioning device

[0239] 64d Chamfer at the end of positioning device

[0240] 64e Vertex below the circumferential recess

[0241] 64f Upper end of positioning device

[0242] 65 Circumferential recess of positioning device (exhaust device and flexure device)

[0243] 66 Main clearance of positioning device (exhaust device)

[0244] 67 Smaller axial groove in positioning device (exhaust device)

[0245] 69 Accessible channel (exhaust device)

[0246] 121 Injection device

[0247] 200 Loading

[0248] Circumferential protrusion of the charge

[0249] Circumferential recess of the charge

[0250] Outlet hole 300

[0251] Shoulder of the receiver

[0252] Inward protrusion of the receiver cylinder

[0253] Pressurizing gas P

[0254] Clearance of the top of the positioning device above the top of the receiver

Claims

1. A loading device (2) comprising a set of one or more loading cylinders (63), each loading cylinder (63) having a charge (200), wherein, For each loading cylinder: a. The loading cylinder has an outlet hole (300) and a flexible positioning device (64) at the outlet hole (300); wherein the flexible positioning device includes an outer surface having a top end, and the flexible positioning device (64) has a circumferential recess provided in the outer surface at which the top end meets the loading cylinder, and wherein the positioning device has its thickest point below the circumferential recess and then tapers towards its lower end; b. The charge (200) is located within the loading cylinder (63); c. The loading cylinder (63) is arranged such that the charge (200) can leave the loading cylinder (63) via the outlet hole (300); wherein one or more loading cylinders (63) each have an exhaust device arranged to: allow gas to escape from the loading cylinder (63) when the charge (200) leaves the loading cylinder (63) through the outlet hole (300).

2. The loading device (2) according to claim 1, wherein, For one or more exhaust devices, the exhaust device is a hole.

3. The loading device (2) according to claim 2, wherein, For one or more loading cylinders (63), the exhaust device is located in the positioning device (64) or the loading cylinder (63).

4. The loading device (2) according to any one of claims 1 to 3, wherein, One or more loading cylinders (63) comprise a polymer.

5. The loading device (2) according to any one of claims 1 to 3, wherein, For one or more loading cylinders (63), the length of the loading cylinder (63) is not greater than 3 times the length of the charge (200).

6. The loading device (2) according to any one of claims 1 to 3, wherein, For one or more loading cylinders (63), the distance between the charge (200) and the outlet hole (300) is not greater than 4 times the length of the charge (200).

7. The loading device (2) according to any one of claims 1 to 3, wherein, The loading device (2) has more than 3 loading cylinders (63).

8. The loading device (2) according to any one of claims 1 to 3, wherein, The loading device (2) is located within a sterile container.

9. The loading device (2) according to any one of claims 1 to 3, wherein, One or more charges (200) comprise a thermoplastic elastomer.

10. A kit comprising the loading device (2) according to any one of the preceding claims 1 to 9 and a receiving device (1), the receiving device (1) comprising one or more receiving cylinders (12), each receiving cylinder (12) having a receiver (5) inside it; wherein each receiver (5) has an inlet hole (53); wherein each receiver (5) is adapted to receive the charge (200) from the loading cylinder (63) through its inlet hole (53).

11. The kit according to claim 10, wherein, One or more of a group of recipients (5) are selected from the group consisting of: cartridges, syringes, syringe precursors, and vials.

12. A method of preparing one or more closed receivers, comprising the following process steps: a. Providing the kit according to claim 10 or 11; b. One or more charges are discharged from a charge cylinder (63) through an outlet hole (300) of the charge cylinder (63) into a respective receiver (5) via an inlet hole (53) of the respective receiver (5).

13. The method according to claim 12, wherein Before step b., the pressure inside one or more receivers (5) is at least 10 4 Pa.

14. The method according to claim 12 or 13, wherein Material is introduced into one or more recipients (5) between step a. and step b.

15. Use of a charge cylinder having an exhaust device during the process of plugging it at a pressure of at least 10 4 Pa, wherein each charge cylinder (63) has a charge (200), wherein For each loading cylinder: a. The loading cylinder has an outlet hole (300) and a flexible positioning device (64) at the outlet hole (300); wherein the flexible positioning device includes an outer surface having a top end, and the flexible positioning device (64) has a circumferential recess provided in the outer surface at which the top end meets the loading cylinder, and wherein the positioning device has its thickest point below the circumferential recess and then tapers towards its lower end; b. The charge (200) is located within the loading cylinder (63); c. The loading cylinder (63) is arranged such that the charge (200) can leave the loading cylinder (63) via the outlet hole (300); wherein one or more loading cylinders (63) each have an exhaust device arranged to: allow gas to escape from the loading cylinder (63) when the charge (200) leaves the loading cylinder (63) through the outlet hole (300).

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