Syringe filling adapter

Abstract

A filling adapter for delivering a medical liquid to a container has a body with a distal end, a proximal end, and a central hole extending along a longitudinal axis between the distal end and the proximal end. The central hole has an angled portion at the proximal end of the body so that the diameter of the central portion increases in a direction from the distal end to the proximal end at the angled portion. The flow adapter further has a flow controller, which is arranged in the central hole at the distal end of the angled portion so that a gap is formed between the outer surface of the flow controller and the inner surface of the central hole. The flow controller is shaped to guide the liquid flowing through the central hole through the gap and flow along the angled portion of the central hole under the Coanda effect.

Description

[0001] This application is a divisional application of Chinese patent application No. 201680066361.3, filed on November 23, 2016, which is a Chinese national phase application of PCT international patent application PCT / US2016 / 063461 and claims priority to U.S. provisional patent application No. 62 / 259,906.

[0002] CROSS-REFERENCE TO RELATED APPLICATIONS

[0003] This application claims priority to U.S. Provisional Patent Application No. 62 / 259,906, filed on November 25, 2015, and entitled “Syringe Fill Adapter,” the disclosure of which is incorporated herein by reference in its entirety. Technical Field

[0004] The present disclosure relates generally to syringes, filling adapters, and syringe and fluid transfer assemblies for use in fluid delivery systems, and more specifically to syringes, filling adapters, and syringe and fluid transfer assemblies for use in medical fluid delivery systems in which fluid is delivered to a patient in a time-limited manner. Background Art

[0005] In many medical procedures (e.g., drug delivery), it is desirable to inject a liquid into a patient. During diagnostic and therapeutic procedures, many types of liquids, such as contrast media (often referred to simply as "contrast agents") and / or saline, may be injected into a patient. In some medical procedures, such as angiography, computed tomography (CT), ultrasound, magnetic resonance imaging (MRI), nuclear medicine, and positron emission tomography (PET), it is necessary to deliver a liquid, such as a contrast agent, under pressure in a timed manner. Injectors suitable for such applications typically use relatively large volume syringes and are capable of producing relatively large flow rates.

[0006] Medical personnel work under increasingly difficult time and physical constraints. Therefore, it is desirable to fill syringes or other liquid containers as quickly as possible and to connect and disconnect fluid delivery systems as quickly as possible. However, filling large syringes with liquids such as contrast agents is typically a time-consuming process. Conventional syringes have a distal opening that is typically used to fill the interior of the syringe with liquid. The size of this distal opening has significant limitations on the filling rate. In addition, since conventional syringes are typically transported with the plunger in a fully retracted position, filling the syringe first requires moving the plunger to the distal end of the syringe so as to expel air from the syringe and start the liquid filling process. Since the cost of many medical procedures such as diagnostic imaging increases in relation to duration, any delay may significantly increase the cost.

[0007] In addition, in many such fluid delivery systems, it is necessary to form a fluid connection between multiple separate fluid path components. For example, it may be necessary to connect an injector-driven syringe to a flexible plastic tubing, which in turn is connected to a cannula inserted into a patient. Common connectors used in the medical field are Luer connectors or Luer locks. Luer connectors include male connectors or members and female connectors or members. The male member and female member are typically connected via a radially inwardly extending thread attached to the female member, which cooperates with one or more radially outwardly extending flanges on the male Luer member to create a leak-free connection.

[0008] Medical personnel must connect and / or disconnect fluid delivery elements in a relatively short time and under stressful and / or emergency conditions. It is therefore desirable to develop a syringe adapter that is configured for filling a syringe and has a durable syringe and connector interface that can be easily and quickly connected or disconnected. Summary of the invention

[0009] Generally, the present disclosure relates to syringes and filling adapters for use in fluid transfer assemblies for medical fluid delivery systems.

[0010] According to some examples of the present disclosure, a filling adapter for delivering a medical fluid to a container may have a body having a distal end, a proximal end, and a central hole extending along a longitudinal axis between the distal end and the proximal end. The central hole may have an angled portion at the proximal end of the body so that the diameter of the central portion increases in a direction from the distal end to the proximal end at the angled portion. The filling adapter may further have a flow controller arranged in the central hole at the distal end of the angled portion so that a gap is formed between the outer surface of the flow controller and the inner surface of the central hole. The flow controller may be shaped to guide the fluid flowing through the central hole through the gap and flow along the angled portion of the central hole under the Coanda effect.

[0011] According to other examples of the present disclosure, at least a portion of the flow controller may be connected to the inner surface of the central hole by one or more spokes. Each of the one or more spokes may have a first end connected to the inner surface of the central hole and a second end connected to the flow controller. Each of the one or more spokes may be flexible and elastic, so that the flow controller is movable in the direction of the longitudinal axis of the body with the flow of the liquid. The flow controller may have a curved distal surface. The curved distal surface of the flow controller may be convex. The curved distal surface may have a flow diverter extending distally from the central portion of the curved distal surface. The flow diverter may be shaped to guide the fluid flowing through the central hole in a radially outward direction toward the gap. The flow controller may have a curved proximal surface. The curved proximal surface of the flow controller may be convex. The body may have a flange at the distal end, which extends radially outward relative to the outer surface of the body. At least a portion of the body may be configured to be removably received in the open distal end of the container.

[0012] According to other examples of the present disclosure, a fluid transfer assembly may have a syringe for receiving a medical liquid therein and a filling adapter. The syringe may have a proximal end, a distal end having an open-ended syringe neck, and a sidewall extending along a longitudinal axis between the proximal end and the distal end. The syringe may define an internal volume for receiving the medical liquid therein. The filling adapter may be received within the open-ended syringe neck. The filling adapter may have a body having a distal end, a proximal end, and a central hole extending along a longitudinal axis between the distal end and the proximal end. The central hole may have an angled portion at the proximal end of the body so that the diameter of the central portion increases in a direction from the distal end to the proximal end at the angled portion. The filling adapter may further have a flow controller disposed within the central hole at the distal end of the angled portion so that a gap is formed between the outer surface of the flow controller and the inner surface of the central hole. The flow controller may be shaped to guide the liquid flowing through the central hole through the gap and flow along the angled portion of the central hole under the Coanda effect.

[0013] According to other examples of the present disclosure, the outer portion of the syringe neck may have a flange extending around at least a portion of the circumference of the syringe neck. At least a portion of the flange may be configured to engage a cap for closing the distal end of the syringe. The syringe may have a drive member engagement portion that extends proximally from the end wall that closes the proximal end and is configured to engage with the drive member of the fluid injector. The sidewall of the syringe may be flexible and roll up when the drive member of the fluid injector acts on it, so that the outer surface of the sidewall is folded in a radially inward direction as the drive member is advanced from the proximal end to the distal end, and wherein the outer surface of the sidewall is unfolded in a radially outward direction as the drive member is withdrawn from the distal end to the proximal end. At least a portion of the flow controller may be connected to the inner surface of the central hole by one or more spokes. Each of the one or more spokes may have a first end connected to the inner surface of the central hole and a second end connected to the flow controller. The flow controller may have a curved distal surface.

[0014] According to other examples of the present disclosure, a fluid transfer assembly may have a syringe for receiving a medical fluid therein, the syringe having a proximal end, a distal end having an open-ended syringe neck, and a sidewall extending along a longitudinal axis between the proximal end and the distal end. The syringe may define an internal volume for receiving the medical fluid therein. The fluid transfer assembly may further have a filling adapter received within the open-ended syringe neck. The fluid transfer assembly may further have a cap fixed to the syringe neck, the cap having a mouth in fluid communication with the internal volume of the rolling diaphragm syringe. The filling adapter may have a body with a distal end, a proximal end, and a central hole extending along a longitudinal axis between the distal end and the proximal end. The central hole may have an angled portion at the proximal end of the body, such that the diameter of the central portion increases at the angled portion in a direction from the distal end to the proximal end. The filling adapter may further have a flow controller disposed within the central hole at the distal end of the angled portion, such that a gap is formed between an outer surface of the flow controller and an inner surface of the central hole. The flow controller can be configured to direct the liquid flowing through the central hole through the gap and flow along the angled portion of the central hole under the Coanda effect. The outer portion of the syringe neck can have a flange extending around at least a portion of the circumference of the syringe neck, and the cover can have one or more tabs configured to releasably engage at least a portion of the flange. The one or more tabs can have a first end connected to the cover and a second end extending proximally from the first end. The second end can be deflected in a radially outward direction when the cover contacts the flange on the syringe neck.

[0015] Various other aspects of the present disclosure are set forth in one or more of the following clauses:

[0016] Item 1: A filling adapter for delivering a medical fluid to a container, the filling adapter comprising: a body having a distal end, a proximal end, and a central hole extending along a longitudinal axis between the distal end and the proximal end, the central hole having an angled portion at the proximal end of the body so that a diameter of the central portion increases at the angled portion in a direction from the distal end to the proximal end; and a flow controller arranged in the central hole at the distal end of the angled portion so that a gap is formed between an outer surface of the flow controller and an inner surface of the central hole, wherein the flow controller is shaped to guide a liquid flowing through the central hole to pass through the gap and flow along the angled portion of the central hole under a Coanda effect.

[0017] Item 2: A filling adapter as described in Item 1, wherein at least a portion of the flow controller is connected to the inner surface of the central hole by one or more spokes, the one or more spokes having a first end connected to the inner surface of the central hole and a second end connected to the flow controller.

[0018] Clause 3: The filling adapter of clause 2, wherein each of the one or more spokes is resiliently flexible such that the flow controller is movable in the direction of the longitudinal axis of the body with the flow of the liquid.

[0019] Clause 4: The filling adapter of any of clauses 1-3, wherein the flow controller has a curved distal surface.

[0020] Clause 5: The filling adapter of Clause 4, wherein the curved distal surface of the flow controller is convex.

[0021] Clause 6: The filling adapter of clause 4, wherein the curved distal surface has a flow diverter extending distally from a central portion of the curved distal surface, the flow diverter being shaped to direct liquid flowing through the central aperture in a radially outward direction toward the void.

[0022] Clause 7: The filling adapter of any of clauses 1-6, wherein the flow controller has a curved proximal surface.

[0023] Clause 8: The filling adapter of Clause 7, wherein the curved proximal surface of the flow controller is convex.

[0024] Clause 9: The filling adapter of any of clauses 1-8, wherein the body has a flange at the distal end that extends radially outward relative to an outer surface of the body.

[0025] Clause 10: The filling adapter of any of clauses 1-9, wherein at least a portion of the body is configured to be removably received within the open distal end of the container.

[0026] Item 11: A fluid transfer assembly comprising: a syringe for receiving a medical fluid therein, the rolling diaphragm syringe comprising: a proximal end, a distal end having an open-ended syringe neck, and a side wall extending along a longitudinal axis between the proximal end and the distal end, the syringe defining an internal volume for receiving the medical fluid therein; and a filling adapter received in the open-ended syringe neck, the filling adapter comprising: a body having a distal end, a proximal end, and a central hole extending along the longitudinal axis between the distal end and the proximal end, the central hole having an angled portion at the proximal end of the body such that a diameter of the central portion increases at the angled portion in a direction from the distal end to the proximal end; and a flow controller arranged in the central hole at the distal end of the angled portion such that a gap is formed between an outer surface of the flow controller and an inner surface of the central hole, wherein the flow controller is shaped to direct a liquid flowing through the central hole to pass through the gap and flow along the angled portion of the central hole under a Coanda effect.

[0027] Clause 12: The fluid transfer assembly of Clause 11, wherein the outer portion of the syringe neck has a flange extending around at least a portion of the circumference of the syringe neck.

[0028] Clause 13: The fluid transfer assembly of any of Clauses 11-12, wherein at least a portion of the flange is configured to engage a cap closing the distal end of the syringe.

[0029] Clause 14: The fluid transfer assembly of any of clauses 11-13, wherein the syringe has a drive member engagement portion that protrudes proximally from an end wall closing the proximal end and is configured for engagement with a drive member of a liquid injector.

[0030] Item 15: A fluid transfer assembly as described in any of Items 11-14, wherein the side wall of the syringe is flexible and rolls up upon itself when acted upon by a drive member of a liquid injector, such that an outer surface of the side wall folds in a radially inward direction as the drive member is advanced from the proximal end to the distal end, and wherein the outer surface of the side wall unfolds in a radially outward direction as the drive member is withdrawn from the distal end to the proximal end.

[0031] Item 16: A fluid transfer component as described in any of Items 11-15, wherein at least a portion of the flow controller is connected to the inner surface of the central hole by one or more spokes, and wherein each of the one or more spokes has a first end connected to the inner surface of the central hole and a second end connected to the flow controller.

[0032] Clause 17: The fluid transfer assembly of any of clauses 11-16, wherein the flow controller has a curved distal surface.

[0033] Item 18: A fluid transfer assembly comprising: a syringe for receiving a medical fluid therein, the rolling diaphragm syringe comprising: a proximal end, a distal end having an open-ended syringe neck, and a sidewall extending along a longitudinal axis between the proximal end and the distal end, the syringe defining an internal volume for receiving the medical fluid therein; a filling adapter received within the open-ended syringe neck, the filling adapter comprising: a body having a distal end, a proximal end, and a central bore extending along the longitudinal axis between the distal end and the proximal end, the central bore having an angled An angled portion such that the diameter of the central portion increases in a direction from the distal end to the proximal end at the angled portion; and a flow controller arranged in the central hole at the distal end of the angled portion such that a gap is formed between the outer surface of the flow controller and the inner surface of the central hole; and a cap fixed to the neck of the syringe, the cap having a mouth in fluid communication with the internal volume of the rolling diaphragm syringe, wherein the flow controller is shaped to guide the liquid flowing through the central hole to pass through the gap and flow along the angled portion of the central hole under the Coanda effect.

[0034] Clause 19: The fluid transfer assembly of clause 18, wherein the outer portion of the syringe neck has a flange extending around at least a portion of the circumference of the syringe neck, and wherein the cap has one or more tabs configured to releasably engage at least a portion of the flange.

[0035] Clause 20: A fluid transfer assembly as described in Clause 19, wherein the one or more tabs have a first end connected to the cap and a second end extending proximally from the first end, and wherein the second end can be deflected in a radially outward direction when the cap contacts the flange on the syringe neck.

[0036] These and other features and characteristics of the syringe, filling adapter, and syringe and fluid transfer assembly for use in a medical fluid delivery system, as well as the combination of parts and manufacturing economy will become more apparent after considering the following description and the appended claims (all of which form a part of this specification) with reference to the accompanying drawings in which like reference numerals refer to corresponding parts in the different figures. It should be expressly understood, however, that the drawings are for illustration and description purposes only and are not intended to limit the limits of the present disclosure. BRIEF DESCRIPTION OF THE DRAWINGS

[0037] Figure 1 is an exploded side view of a syringe and a fluid transfer assembly according to one example of the present disclosure;

[0038] Figure 2A is a cross-sectional side view of a syringe for use with a filling adapter according to one example of the present disclosure;

[0039] Figure 2B is a perspective view of a syringe for use with a filling adapter according to another example of the present disclosure;

[0040] Figure 3A yes Figure 1 Syringe with Figure 1 A side view of a fluid transfer assembly;

[0041] Figure 3B yes Figure 3A A longitudinal cross-sectional view of

[0042] Figure 4 yes Figure 3A A side view of a syringe and a fluid transfer assembly in a first engaged position;

[0043] Figure 5 yes Figure 3A A side view of the syringe and the fluid transfer assembly in a second engaged position;

[0044] Figure 6 yes Figure 5 A longitudinal cross-sectional view of

[0045] Figure 7 yes Figure 1 A side view of the syringe and fluid transfer assembly after the syringe has been filled with fluid and the piercing device has been disengaged from the filling adapter;

[0046] Figure 8 yes Figure 7 A longitudinal cross-sectional view of

[0047] Fig. 9 yes Figure 7 A side view of a syringe;

[0048] Fig.10 yes Fig. 9 A longitudinal cross-sectional view of

[0049] Fig.11 yes Figure 7 Detailed cross-sectional view of a fill adapter;

[0050] Fig.12 is a perspective view of a syringe and a fluid transfer assembly according to another example of the present disclosure;

[0051] Fig.13 yes Fig.12 A detailed cross-sectional side view of a connection interface of a filling adapter;

[0052] Fig.14 is a detailed cross-sectional side view of a fluid transfer assembly according to another example of the present disclosure.

[0053] Fig.15A is a perspective view of a fluid transfer assembly according to another example of the present disclosure;

[0054] Fig. 15B yes Fig.15A Another perspective view of the fluid transfer assembly;

[0055] Fig.16 is an exploded perspective view of a fluid transfer assembly according to another example of the present disclosure;

[0056] Fig.17A is a perspective view of a fluid transfer assembly according to another example of the present disclosure;

[0057] Fig. 17B yes Fig.17A A detailed cross-sectional side view of a fluid transfer assembly;

[0058] Fig.18A is a perspective view of a fluid transfer assembly according to another example of the present disclosure;

[0059] Fig.18B yes Fig.18A Another perspective view of the fluid transfer assembly;

[0060] Fig. 18C yes Fig.18A A detailed cross-sectional side view of a fluid transfer assembly;

[0061] Fig.18D yes Fig.18A A detailed cross-sectional side view of a spike adapter;

[0062] Fig.18E yes Fig.18A A detailed cross-sectional side view of a connection interface of a filling adapter;

[0063] Fig.19A is a perspective view of a fluid transfer assembly according to another example of the present disclosure;

[0064] Fig.19B yes Fig.19A Another perspective view of the fluid transfer assembly;

[0065] Fig. 20 is a perspective view of a fluid transfer assembly according to another example of the present disclosure;

[0066] Fig.21A is a detailed cross-sectional side view of a connection interface of a filling adapter according to another aspect;

[0067] Fig.21B yes Fig.21A A detailed cross-sectional perspective view of the connection interface;

[0068] Fig. 21C is with Fig.21A A perspective view of a syringe conforming to a filling adapter;

[0069] Fig.21D yes Fig.21A A perspective view of a ribbed connector of a fill adapter;

[0070] Fig.21E yes Fig.21A A perspective view of a flow controller filling an adapter;

[0071] Fig.21F is based on Fig.21A A perspective view of a ribbed connector of another example of a fill adapter;

[0072] Fig.22A is a perspective view of a fluid transfer assembly according to another aspect;

[0073] Fig. 22B yes Fig.22A A detailed cross-sectional side view of a fluid transfer assembly;

[0074] Fig. 22C yes Fig.22A A detailed cross-sectional side view of a connection interface of a filling adapter;

[0075] Fig.22D yes Fig.22A an exploded view of a valve housing of a fluid transfer assembly;

[0076] Fig.23A is a perspective view of a fluid transfer assembly according to another example of the present disclosure;

[0077] Fig. 23B yes Fig.23A A detailed cross-sectional side view of a connection interface of a filling adapter;

[0078] Fig.23C yes Fig.23A A perspective view of a spike adapter of a fluid transfer assembly;

[0079] Fig.23D is with Fig.23A A perspective view of an aspect of a fill adapter conforming to a flow controller;

[0080] Fig.24A is with Fig.23A A detailed cross-sectional side view of a connection interface consistent with another example of a fill adapter;

[0081] Fig. 24B yes Fig.24A a perspective view of a flow controller having a connection interface;

[0082] Fig.25A is with Fig.23A A detailed cross-sectional side view of a connection interface consistent with another example of a fill adapter;

[0083] Fig.25B yes Fig.25A a perspective view of a flow controller having a connection interface;

[0084] Fig.26A is with Fig.23A A detailed cross-sectional side view of another aspect of the fill adapter conforming to the connection interface;

[0085] Fig.26B yes Fig.26A a perspective view of a flow controller having a connection interface;

[0086] Fig.27A is a perspective view of a fluid transfer assembly according to another example of the present disclosure;

[0087] Fig.27B yes Fig.27A A detailed cross-sectional side view of a connection interface of a filling adapter;

[0088] Fig.27C yes Fig.27A Another perspective view of the fluid transfer assembly;

[0089] Fig.27D yes Fig.27C A detailed cross-sectional side view of a connection interface of a filling adapter;

[0090] Fig.27E yes Fig.27A A perspective view of a slide valve of a fluid transmission assembly;

[0091] Fig.27F yes Fig.27E An exploded perspective view of a slide valve;

[0092] Figure 27G yes Fig.27E A detailed cross-sectional side view of a slide valve;

[0093] Fig.28A is a perspective view of a fluid transfer assembly according to another example of the present disclosure;

[0094] Fig.28B yes Fig.28A A detailed cross-sectional side view of a connection interface of a filling adapter;

[0095] Fig.29 is an exploded perspective view of a syringe assembly according to another example of the present disclosure;

[0096] Fig. 30A is a perspective view of a syringe with a filling adapter according to another example of the present disclosure;

[0097] Fig. 30B yes Fig. 30A Detailed perspective top view of a syringe and filling adapter;

[0098] Fig. 30C yes Fig. 30A A cross-sectional side view of a syringe and a filling adapter;

[0099] Fig.30D yes Fig. 30A A perspective top view of the filling adapter after it has been removed from the syringe;

[0100] Fig.31A is a cross-sectional side view of a syringe and a filling adapter according to another example of the present disclosure;

[0101] Fig.31B yes Fig.31A A perspective top view of the filling adapter after it has been removed from the syringe;

[0102] Fig.32A is an exploded perspective view of a syringe, a filling adapter, and a cap according to another example of the present disclosure;

[0103] Fig.32B yes Fig.32A A perspective view of the syringe, filling adapter, and cap shown in assembled form;

[0104] Fig.32C yes Fig.32A A cross-sectional side view of a syringe, a filling adapter, and a cap;

[0105] Fig.32D yes Fig.32A A perspective view of a syringe;

[0106] Fig.33A is an exploded perspective view of a syringe, a filling adapter, and a cap according to another example of the present disclosure;

[0107] Fig.33B yes Fig.33A A perspective view of a syringe;

[0108] Fig.33C yes Fig.33A A perspective view of the lid;

[0109] Fig.34A is a cross-sectional side view of a syringe and a filling adapter according to another example of the present disclosure, showing a flow controller in a closed position; and

[0110] Fig.34B yes Fig.34A A cross-sectional side view of a syringe and filling adapter showing the flow controller in an open position. DETAILED DESCRIPTION

[0111] The display generally illustrates a number of non-limiting examples of the present disclosure. Although the present description presents a variety of different examples, it should not be construed as limiting the present disclosure in any way. In addition, modifications, concepts, and applications of the examples of the present disclosure should be interpreted by those skilled in the art as being encompassed, but not limited to, the illustrations and descriptions provided herein. Any and all such modifications, variations, equivalents, and alternatives are intended to fall within the spirit and scope of the present disclosure.

[0112] As used in the specification and claims, the singular forms of "a," "an," and "the" include plural referents unless the context clearly dictates otherwise.

[0113] For the purposes of the description below, the terms "upper", "lower", "right", "left", "vertical", "horizontal", "top", "bottom", "lateral", "longitudinal", and their derivatives shall refer to components as oriented in the accompanying drawings. When used with respect to a syringe, the term "proximal end" refers to the portion of the syringe that is closest to the injector when the syringe is oriented to be connected to the injector. The term "distal end" refers to the portion of the syringe that is farthest from the injector when the syringe is oriented to be connected to the injector. The term "radial" refers to a direction in a cross-sectional plane perpendicular to the longitudinal axis of the syringe extending between the proximal end and the distal end. The term "circumferential" refers to a direction around the inner or outer surface of the side wall of the syringe. The term "axial" refers to a direction extending along the longitudinal axis of the syringe between the proximal end and the distal end. The term "flexible" when used in conjunction with a syringe means that at least a portion of the syringe (e.g., the side wall of the syringe) can be bent or curved to change the direction in which it extends. The terms "winding", "rolling", and "self-rolling" refer to the ability of a first portion of a syringe (e.g., a proximal portion of a side wall of a syringe) to bend approximately 180° relative to a second portion of the syringe (e.g., a distal portion of a side wall of a syringe) when pushed by a drive member of a fluid injector.

[0114] Unless otherwise indicated, all ranges or ratios disclosed herein will be understood to include any sub-ranges or sub-ratios included therein. For example, the indicated range "1 to 10" or ratio "1 to 10" should be understood to include any sub-ranges between (and including) the minimum value of 1 and the maximum value of 10, i.e., all sub-ranges or sub-ratios starting with a minimum value of 1 or greater and ending with a maximum value of 10 or less, such as, but not limited to: 1 to (ratio) 6.1, 3.5 to (ratio) 7.8, and 5.5 to (ratio) 10.

[0115] It should be understood that the specific devices and methods shown in the accompanying drawings and described in the following specification are merely exemplary aspects of the present disclosure. Therefore, specific dimensions and other physical characteristics related to the aspects disclosed herein should not be considered limiting.

[0116] All references, such as but not limited to issued patents and patent applications cited herein, are deemed to be "incorporated by reference" in their entirety unless otherwise noted.

[0117] With reference to the accompanying drawings, in which like parts are referred to by like reference numerals throughout the several views thereof, syringes, filling adapters, and syringe and fluid delivery assemblies used in medical fluid delivery systems are described in detail herein. The present disclosure also provides other connectors suitable for use with the syringes disclosed herein and for use with other fluid path elements or fluid pumping systems. In general, the connectors of the present disclosure are suitable for use in low-pressure and high-pressure fluid injection systems.

[0118] See also Figure 1 and Figure 3A-11 , according to an example, a fluid transfer assembly 10 for delivering medical liquids is shown. The fluid transfer assembly 10 is configured to facilitate the transfer of liquid from a second liquid container 36 to a first liquid container 12. In some examples, the first liquid container 12 and / or the second liquid container 36 can be a syringe, a vial, a bottle, a bag, or other containing structure configured to receive a certain volume of liquid therein. In some examples, the first liquid container 12 can be a syringe, and the second liquid container 36 can be a large-capacity liquid storage container, such as a bottle or a bag.

[0119] Continue to see Figure 1, the fluid transfer assembly 10 further includes a filling adapter 32 configured to facilitate the transfer of liquid between the two liquid containers, for example, from the second liquid container 36 to the first liquid container 12. The filling adapter 32 may be removably connectable to the first liquid container 12 and / or the second liquid container 36. In some examples, the filling adapter 32 may be non-removably connectable to one of the first liquid container 12 and the second liquid container 36 and removably connectable to the other of the first liquid container 12 and the second liquid container 36. The filling adapter 32 may have an integral, one-piece structure, or it may be formed of two or more components that are removably or non-removably coupled together.

[0120] The filling adapter 32 can be configured to operate between a first state and a second state. In the first state, liquid flow can be blocked so that liquid cannot be transferred between the two liquid containers, such as from the second liquid container 36 to the first liquid container 12. In the second state, liquid can flow between the two liquid containers, such as from the second liquid container 36 through the filling adapter 32 to the first liquid container 12. As described herein, the filling adapter 32 can be movable between the first position and the second position so as to correspondingly affect operation between the first state and the second state.

[0121] See also Figure 1 and Figure 3A-3B , the fluid transfer assembly 10 can have a locking mechanism 108 that is removably connectable to at least two of the first liquid container 12, the filling adapter 32, and the second liquid container 36. The locking mechanism 108 can be configured to prevent the components of the fluid transfer assembly 10 from moving between the first position and the second position to prevent liquid from flowing between the two containers, such as from the second liquid container 36 to the first liquid container 12. The locking mechanism 108 can be a bracket that is removable from the fluid transfer assembly 10, or it can be movable from the first position to the second position. In the first position, the locking mechanism 108 can prevent the filling adapter 32 from being activated from the first state to the second state, thereby preventing liquid from flowing from the second liquid container 36 to the first liquid container 12. In the second position, the locking mechanism 108 can enable the filling adapter 32 to be activated to the second state, thereby allowing liquid to flow from the second liquid container 36 to the first liquid container 12.

[0122] See also Figure 2A , a non-limiting example of the first liquid container 12 is shown as a rolling diaphragm syringe 12a having a flexible side wall. Figures 3A-33CIn any of the examples of the present disclosure described, the rolling diaphragm injector 12a can be used as the first liquid container. The rolling diaphragm injector 12a is adapted for use in CT, MRI, PET and similar procedures and is operable at a typical operating pressure of, for example, approximately 10-300 psi, such as 200-300 psi, depending on the viscosity of the liquid and the desired injection rate. In some examples, the rolling diaphragm injector 12a can be configured for use in procedures such as angiography that require pressures on the order of 1,200 psi. In some aspects, the rolling diaphragm injector 12a can be an injector disclosed in International Patent Application No. PCT / US 2015 / 027582 and / or International Patent Application No. PCT / US 2016 / 028824, the disclosures of which are incorporated herein by reference.

[0123] Continue to see Figure 2A , the rolling diaphragm syringe 12a generally includes a hollow body including a front end or distal end 18, a rear end or proximal end 16, and a flexible sidewall 20 extending therebetween along a longitudinal axis L. In use, the proximal end 16 is configured to be inserted into a through hole of a pressure jacket attached to a liquid injector so that the sidewall 20 is surrounded by the inner surface of the pressure jacket. At least a portion of the distal end 18 of the rolling diaphragm syringe 12a may be exposed from the distal end 18 of the pressure jacket. In some instances, the rolling diaphragm syringe 12a may be formed using a blow molding technique. In other instances, the rolling diaphragm syringe 12a may be injection molded.

[0124] Continue to see Figure 2A , the proximal end 16 of the syringe 12a is connected to the closed end wall 30, and the distal end 18 of the rolling diaphragm syringe 12a defines a syringe neck 22 opposite the closed end wall 30. The distal end 18 can have a truncated cone shape that gradually narrows from the side wall 20 to the syringe neck 22. The syringe neck 22 is open to allow liquid to be introduced into the interior of the syringe and / or delivered therefrom. The closed end wall 30 can be shaped to interface directly or indirectly with a drive member of a liquid injector (not shown). For example, the closed end wall 30 can define a receiving end recess for direct interface connection with a similarly shaped drive member, which can be shaped to substantially match the shape of the closed end wall 30. The side wall 20 and / or the end wall 30 can have a uniform or non-uniform thickness. For example, the side wall 20 can have an increased thickness at the distal end 18 compared to the end wall 30.

[0125] The side wall 20 of the rolling diaphragm syringe 12a defines a soft, pliable or flexible, yet self-supporting body that is configured to roll up on itself under the action of the drive member. Specifically, the side wall 20 of the rolling diaphragm syringe 12a is configured to roll up on itself so that its outer surface is folded and turned inward in a radially inward direction when the drive member moves in a distal direction, and unrolled and unfolded in a radially outward direction in the opposite manner when the drive member is retracted in a proximal direction.

[0126] The rolling diaphragm syringe 12a may be made of any suitable medical grade plastic material or polymer material, desirably a transparent or substantially translucent plastic material, such as, but not limited to, polypropylene random copolymer, polypropylene impact copolymer, polypropylene homopolymer, polypropylene, polyethylene terephthalate, POM, ABS, HPDE, nylon, cyclic olefin copolymer, multilayer polypropylene, polycarbonate, ethylene vinyl acetate, polyethylene, etc. The material of the rolling diaphragm syringe 12a is desirably selected to meet the desired tensile stress and plane stress requirements, water vapor transmission rate, and chemical / biocompatibility.

[0127] The distal end 18 (e.g., syringe neck 22) of the rolling diaphragm syringe 12a can have a connection member 130a at the distal end 18 for connecting to a corresponding cap member, such as at least a portion of the filling adapter 32 described herein. In some aspects, the connection member 130a is a threaded interface having one or more threads to match corresponding threads on the filling adapter 32. In some aspects, the connection member 130a can be configured to connect to the filling adapter 32 via a Luer-type connection. In other aspects, the connection member 130a can have one or more lips or grooves that interact with corresponding grooves or lips on the filling adapter 32 to releasably or non-releasably retain the rolling diaphragm syringe 12a with the filling adapter 32. The connection between the filling adapter 32 and the syringe 12a can have at least one seal, such as an O-ring seal, for preventing leakage of liquid at the connection interface between the filling adapter 32 and the syringe 12a. The syringe neck 22 can also be configured to be fluidly connected to a fluid path kit (not shown) that can be connected to a patient. In some examples, the liquid path kit can be in the form of a tube configured to deliver liquid from the first liquid container 12 to the patient, or a container for receiving liquid. In some examples, the liquid path kit is removably connectable to the syringe neck 22 of the first liquid container 12.

[0128] The end wall 30 can have a central portion 132 including a substantially dome-shaped structure and a drive member engagement portion 134 extending proximally from the central portion 132, for example from the approximate midpoint of the central portion 132. In some aspects, the distal-most end of the central portion 132 can be substantially flat. The drive member engagement portion 134 is configured to engage with an engagement mechanism on a drive member of a liquid injector. The proximal end 16 of the rolling diaphragm syringe 12a can have one or more ribs 136 extending radially outward from the drive member engagement portion 134 along the proximal surface of the central portion 132. In some embodiments, the rolling diaphragm syringe 12a can be initially in a compressed, rolled-up configuration when engaged with the injector, and the drive member can engage the drive member engagement portion 134 to withdraw the end wall 30, thereby unrolling the side wall 20 to allow filling of the interior of the syringe.

[0129] See also Figure 2B , a non-limiting example of the first liquid container 12 is shown as a syringe 12b having a substantially rigid side wall. Figures 3A-33C In any example of the present disclosure described, the syringe 12b can be used as the first liquid container. The syringe 12b is adapted to be used in CT, MRI, PET and similar procedures and is operable at a typical operating pressure of, for example, approximately 10-300 psi, for example, 200-300 psi, depending on the viscosity of the liquid and the desired injection speed. In some examples, the syringe 12b can be configured to be used in procedures such as angiography that require pressures on the order of 1,200 psi. In some aspects, the syringe 12b can be a syringe described in U.S. Patent No. 9,173,995, the disclosure of which is incorporated herein by reference in its entirety.

[0130] Syringe 12b generally has a syringe barrel 14 formed of glass, metal, suitable medical grade plastic, or a combination thereof. The barrel 14 has a proximal end 16 and a distal end 18, with a sidewall 20 extending along the length of a longitudinal axis L between the proximal end and the distal end. A syringe neck 22 extends from the distal end 18 of the barrel 14. The barrel 14 has an outer surface 24 and an inner surface 26, which defines an internal volume configured to receive liquid therein. The proximal end 16 of the barrel 14 can be sealed with a plunger 31 that can slide through the barrel 14. When the plunger 31 is advanced or retracted through the barrel 14, the plunger forms a liquid-tight seal against the inner surface 26 of the sidewall 20. The plunger 31 can have an internal rigid element that is configured to engage with a drive member of a liquid injector (not shown). The plunger 31 can further include an elastomeric cover that is arranged on at least a portion of the internal rigid element. The elastomeric cover is configured to engage the inner surface 26 of the barrel 14 and provide a liquid-tight seal against the inner surface of the sidewall 20 of the barrel 14 .

[0131] Continue to see Figure 2B , the proximal end 16 of the syringe 12b is sized and adapted to be removably inserted into the syringe port of the injector. In some examples, the proximal end 16 of the syringe 12b defines an insertion portion that is configured to be removably inserted into the syringe port of the injector 10 while the remainder of the syringe 12b remains outside the syringe port.

[0132] In some instances, the proximal end 16 of the syringe 12b includes one or more syringe retaining members 33, which are adapted to form a locking engagement with a corresponding locking mechanism in the syringe port of the injector so as to releasably retain the syringe 12b in the syringe port. The combination of the syringe 12b with the one or more syringe retaining members 33 and the locking mechanism of the injector defines a connection interface for loading the syringe 12b onto the injector and unloading therefrom. In some instances, at least a portion of the one or more syringe retaining members 33 can cooperate with at least a portion of the locking mechanism so that the syringe 12b is self-oriented relative to the syringe port, so that the syringe 12b can be releasably inserted into the syringe port and locked therewith. The one or more syringe retaining members 33 can be formed as one or more lugs 34, which radially protrude outward from the outer surface 24 of the syringe barrel 14 relative to the longitudinal axis L. In some instances, a plurality of lugs 34 can be radially spaced apart around the circumference of the barrel 14. In such instances, the lugs 34 are spaced apart from each other by a plurality of portions of the outer surface 24 of the barrel 14. Each of the one or more lugs 34 may have a generally triangular, rectangular, polygonal, or arrowhead shape.

[0133] See also Figure 3A , the locking mechanism 108 can be a "U" shaped bracket having a mounting piece 110 at a first end 112 adapted to be connected to the first liquid container 12 and a mounting piece 114 at a second end 116 adapted to be connected to the second liquid container 36. The length of the middle portion 118 of the locking mechanism 108 (defined as the length between the first end 112 and the second end 116) is longer than the longitudinal length of the filling adapter 32, so that when the locking mechanism 108 is secured to both the first liquid container 12 and the second liquid container 36, the filling adapter 32 will be in the first engagement position (i.e., engaged only with the first liquid container 12 and not with the second liquid container 36).

[0134] The fluid transfer assembly 10 may further include a flexible sheath 120 made of any durable and flexible material (e.g., rubber) for enclosing and protecting the filling adapter 32. The flexible sheath 120 may be collapsible or compressible to accommodate movement of the filling adapter 32 from the first position to the second position.

[0135] See also Figure 3B , the second liquid container 36 can have a cylindrical barrel 38 formed of glass, metal, suitable medical grade plastic, or a combination thereof, or can be a plastic bag, such as a saline bag. The barrel 38 has a proximal end 40 and a distal end 42, and a sidewall 44 extends along a longitudinal axis 45 between the proximal end and the distal end. A liquid delivery section, such as a neck 46, extends from the distal end 42 of the barrel 38. The barrel 38 has an outer surface 48 and an inner surface 50, which defines an internal volume 52 configured to receive liquid F therein. The distal end 42 of the second liquid container 36 may include a connection interface for connecting to the filling adapter 32. In some examples, the distal end 42 may be closed by a pierceable septum 54. The filling adapter 32 may be configured to pierce the septum 54 so as to connect the internal volume 52 of the second liquid container 36 to the internal volume 28 of the first liquid container 12, thereby facilitating the transfer of liquid F from the second liquid container 36 to the first liquid container 12.

[0136] Continue to see Figure 3B, the filling adapter 32 has a generally cylindrical body 56 formed of glass, metal, a suitable medical grade plastic, or a combination thereof. The body 56 has a longitudinal axis 58, a distal end 60, and a proximal end 62. The distal end 60 is configured to engage the second liquid container 36 to establish a fluid connection between the second liquid container 36 and the filling adapter 32. The proximal end 62 is configured to engage the first liquid container 12 to establish a fluid connection between the first liquid container 12 and the filling adapter 32. In some examples, the proximal end 62 of the body 56 is configured to be releasably connected to the syringe neck 22.

[0137] The body 56 of the filling adapter 32 is desirably hollow to allow liquid to pass therethrough. In some examples, the body 56 has an inner sidewall 64 and an outer sidewall 66 extending along the longitudinal axis 58 between the distal end 60 and the proximal end 62. In some examples, the inner sidewall 64 can be configured to interface with the inner surface 26 of the syringe neck 22, while the outer sidewall 66 is configured to interface with the outer surface 24 of the syringe neck 22. The outer sidewall 64 is formed with a groove 35 configured to engage with the tab portion 34 located on the outer surface 24 of the syringe neck 22.

[0138] See Figure 6 , the distal end 18 of the first liquid container 12 may include a connection interface for connecting the first liquid container 12 to a filling adapter 32. In some examples, the connection interface may include a tab portion 34 positioned on the outer surface 24 of the barrel 14 on the syringe neck 22 to engage with a groove 35 of the filling adapter 32, thereby securing the filling adapter 32 to the first liquid container 12. When engaged, the filling adapter 32 facilitates the transfer of liquid F from the second liquid container 36 to the first liquid container 12. In other examples, the connection interface between the first liquid container 12 and the filling adapter 32 may be a threaded connection, a welded connection, a molded connection, an interference fit connection, a snap-fit ​​connection, or other mechanical connection.

[0139] See Figure 8 The body 56 removably receives a piercing device 68 configured to pierce the pierceable septum 54 of the second liquid container 36. The piercing device 68 has a generally cylindrical body 70 and includes a longitudinal axis 71, a piercing point 72 located at a distal end 74, and a flared base 76 located at a proximal end 78, the base flaring radially outward away from the longitudinal axis 71. In some examples, the flared base 76 is formed to promote fluid flow due to the Coanda effect. See Figure 6, when received in the body 56 of the filling adapter 32, the body 56 of the filling adapter 32 surrounds the body 70 of the piercing device 68, and the piercing point 72 can extend beyond the distal end 60, while the flared base 76 extends toward the proximal end 62 and into the syringe neck 22. The longitudinal axis 71 of the piercing device 68 can be coaxial with the longitudinal axis 58 of the body 56. The piercing device 68 has a first conduit 80 surrounded by a second annular conduit 82. The first conduit 80 is configured to exhaust air from the interior of the first liquid container 12 during a filling procedure, and the second annular conduit 82 is configured to transfer liquid F from the second liquid container 36 to the first liquid container 12. For some examples, the cross-sectional area of ​​the first conduit 80 can be between 8% and 40% smaller than the cross-sectional area of ​​the second annular conduit 82. The first conduit 80 and the second annular conduit 82 both extend along the longitudinal axis 71 of the piercing device 68. The first conduit 80 and the second annular conduit 82 can have the same or different lengths. The first conduit 80 can be concentric with the second annular conduit 82. In some instances, the first conduit 80 and the second conduit 82 can be arranged side by side in parallel with each other. The first conduit 80 and / or the second annular conduit 82 can have a smooth or spiral inner side wall (not shown). For some instances, the ratio of the cross-sectional area of ​​the trumpet-shaped base 76 to the cross-sectional area of ​​the first conduit 80 can be between 5:1 and 20:1. For other instances, the radius of the trumpet-shaped base 76 is less than or equal to the radius of the transition zone between the distal end of the truncated cone and the syringe neck 22 of the syringe 12 as desired.

[0140] See also Figure 6, the fluid transfer assembly 10 is shown in a second engaged position in which the puncture point 72 penetrates the rubber septum 54 of the second liquid container 36, thereby permitting liquid F to enter the second annular conduit 82. Liquid F travels from the proximal end 78 of the second annular conduit 82 through the filling adapter 32 and into the interior volume 28 of the first liquid container 12 via the syringe neck 22. The liquid flow may be gravity driven, or may be vacuum assisted, such as when the rolling diaphragm syringe 12a is unwound in the proximal direction, or when the plunger 31 of the syringe 12b is withdrawn in the proximal direction. Liquid F entering the first liquid container 12 via the second annular conduit 82 contacts the flared base 76 and is deflected radially outward from the longitudinal axis 71 and toward the inner surface 26 of the barrel 14, then drips down the sidewall 20 of the barrel 14 and accumulates at the bottom of the first liquid container 12. Liquid F flows first through the second annular conduit 82 rather than the first conduit 80 because the first conduit is at a lower point of the filling adapter 32 and will have a higher head pressure than the inlet of the first conduit 80. The entry of liquid F from the second liquid container 36 into the interior of the first liquid container 12 causes air contained in the first liquid container 12 to be expelled into the second liquid container 36 through the first conduit 80. Any liquid that initially flows through the first conduit 80 is forced out of the first conduit 80 by the air flowing from the first liquid container 12 into the second liquid container 36 through the first conduit 80. The air / liquid exchange within the first fluid container 12 occurs substantially simultaneously through the first conduit 80 and the second annular conduit 82 without any flow hesitation or gurgling due to uneven flow characteristics.

[0141] See also Figure 8The piercing device 68 may further include a plurality of deflectable barbs 84 configured to prevent the piercing device 68 from being removed from the second liquid container 36 after the piercing device 68 penetrates the septum 54. The deflectable barbs 84 extend radially outward from the outer surface of the piercing device 68 and form an acute angle therewith. When the piercing point 72 penetrates the pierceable septum 54 of the second liquid container 36, the barbs 84 deflect radially inward toward the longitudinal axis 71, thereby permitting the piercing device 68 to pass through the septum 54 and enter the second liquid container 36. Similarly, when a proximally directed force is applied to the piercing device 68, the deflectable barbs 84 extend radially outward to prevent the piercing device 68 from being removed from the second liquid container 36. This proximally directed force causes the piercing device 68 to be disconnected from the body 56 of the filling adapter 32, while the body 56 is still connected to the syringe neck 22 of the first liquid container 12. In this way, the second liquid container 36 can be discarded together with the piercing device 68 stuck in the syringe neck 46 of the second liquid container 36.

[0142] See also Figure 8 , the filling adapter 32 may further include a plug 85 that is releasably connected to the distal end 78 of the piercing device 68. For removing the piercing device 68 from the body 56, the plug 85 is releasably connected to the distal end 78 of the piercing device 68. Figure 6 ) moves to the second position ( Figure 8 In the first position, the plug 85 is disconnected from the body 56, and in the second position the plug 85 is connected to the body 56, as described herein. Fig.11 The plug 85 has an internal member 86 defining a fluid passage 88 that is in fluid communication with the interior volume 28 of the first fluid container 12. The internal member 86 is aligned with the first conduit of the puncture device (at Fig.11 ). The inner member 86 is surrounded by an outer annular skirt 90 extending axially along at least a portion of the longitudinal length of the inner member 86. The inner member 86 is radially spaced apart from the outer annular skirt 90 by an annular space 92. The outer annular skirt 90 has a threaded portion 94, i.e., a concave Luer lock member formed on an inner surface 96 facing the inner member 86 and configured to connect the first liquid container 12 to a liquid path. The outer surface 98 of the outer annular skirt 90 has at least one leg 100 extending from a portion of the longitudinal length of the outer annular skirt 90 and adapted to fit within a correspondingly shaped recess 102 formed on the inner side wall 64 of the body 56. Once the leg 100 is engaged in the recess 102, the plug 85 is connected to the body 56 to prevent the plug 85 from being removed from the tip of the syringe neck 22. See specifically Figure 8 When the leg 100 is engaged within the recess 102 and the user applies a proximally directed force to the first liquid container 12 to separate the assembly 10, the bottom portion 103 of the barb 84 contacts the septum 54 of the second liquid container 36 and prevents the piercing device 68 from being withdrawn from the second liquid container 36. As a result, the body 70 of the piercing device 68, and the plug 85 attached to the distal end 78 of the piercing device 68, are urged toward the distal end 18 of the first liquid container 12 until the leg 100 is locked within the recess 102. In addition, the proximal force causes the body 70 of the piercing device 68 to be detached from the body 56 of the filling adapter 32, while the plug 85 remains connected to the body 56 and covers the syringe neck 22 of the first liquid container 12. The piercing device 68 can be discarded together with the second liquid container 36.

[0143] See also Fig.11 , a pipeline (not shown) can be optionally connected to the plug 85, thereby establishing a liquid path from the first liquid container 12 to the patient after the first liquid container 12 has been filled with liquid. In some examples, the outer annular skirt 90 of the plug 85 includes a threaded portion 94, i.e., a female Luer lock member, which is formed on the inner surface 96 and is configured to be connected to a pipeline with a male member (not shown) to create a liquid path. In other examples, this arrangement of the female thread 94 and the male member (not shown) can be reversed. In such an example, the male element is provided on the plug 85, and the female wedge thread 94 is provided on the pipeline.

[0144] Continue to see Fig.11 , the inner sidewall 64 of the body 56 can allow the at least one leg 100 to flex radially toward the longitudinal axis 58 so as to facilitate the movement of the plug 85 in the longitudinal direction within the syringe neck 22 when the leg 100 is not engaged in the recess. The outer surface 98 of the plug 85 can further include one or more seals 104 for preventing the liquid F from leaking between the body 56 and the plug 85 when the leg 100 is engaged in the recess 102. Alternatively, the one or more seals 104 can be optionally fixed to the inner sidewall 64 around the recess 102.

[0145] Next, see Fig.12 , discusses a fluid transfer assembly 200 according to another example of the present disclosure. The fluid transfer assembly 200 is configured to eliminate the need to use a vacuum to fill the syringe by activating the plunger. Instead, the fluid transfer assembly 200 relies on the head pressure of the liquid to increase the filling rate by maintaining the liquid container at a certain height above the syringe during the filling process. Fig.12As shown, the fluid transfer assembly 200 has a syringe 202 and a spike adapter 204, which is configured to be connected to a liquid container 201 above the syringe 202. The spike adapter 204 includes a vent 206 to allow air to enter the liquid container during the filling process. A filling pipe 208 connects the syringe 202 and the spike adapter 204, wherein the filling pipe 208 has a tube clamp 210 placed thereon to selectively stop or start the flow of liquid through the filling pipe 208. The tube clamp 210 can be any suitable alternative valve, such as a pinch valve. Although the syringe 202 can be directly connected to the spike adapter 204, the filling pipe 208 increases the head height of the liquid in the liquid container 201 by increasing the distance between the syringe 202 and the liquid container 201. In this way, the filling rate of the syringe 202 can be increased because the flow rate generally increases with the head height when the other flow variables remain constant. In various embodiments, the fill rate of the syringe 202 may be selected by selecting a corresponding head height.

[0146] See also Fig.13 , and continue to see Fig.12 , a valve housing 216 is coupled to the open end of the syringe 202, wherein the valve housing 216 has a connection cap 212 and an optional float 214 or other valve design to allow one-way fluid flow therein. The valve housing 216 further has a fitting 218 configured to connect to a low-pressure connector conduit 220, which can form a wet connection with a separate conduit (not shown) connected to the patient once the syringe is filled and the line is pre-vented. The connector conduit 220 has a pre-vented suction tube 222 connected to a fitting 221 at its distal end. In instances where the float 214 is omitted, a separate valve mechanism (not shown) can be provided to prevent liquid from flowing from the syringe 202 to the liquid container 201.

[0147] Continue to see Fig.13 , the valve housing 216 is shown coupled to the syringe 202, wherein the filling conduit 208 is fluidly coupled to the valve housing 216 via the connecting cap 212. The bell-shaped flow controller 224 is also within the valve housing 216. The open end 226 is configured for fluid communication with the connector conduit 220. During the filling process, the liquid container 201 ( Fig.1224) passes through the fill conduit 208 to the valve housing 216 under the action of gravity. The float 214 or other one-way valve is configured to allow liquid to flow through the valve housing 216 during the initial filling process, wherein the liquid flows down and around the outer surface of the flow controller 224. Optionally, the bell-shaped profile of the surface of the flow controller 224 pushes the liquid along the inner wall of the syringe 202 by the ribbed connector 225. The combination of the bell-shaped profile of the flow controller 224 and the tapered sidewall of the distal end of the syringe 202 (and / or the ribbed connector 225) causes the liquid to fill the syringe 202 according to the Coanda effect. As used herein, the Coanda effect is the tendency of a liquid to be attracted to a nearby curved or angled surface when flowing along the surface. Therefore, as the liquid flows down the flow controller 224 and / or the ribbed connector 225, it is naturally attracted to the inner surface of the tapered distal end 250 of the syringe 202, rather than dripping from the edge of the flow controller 224 and / or the ribbed connector 225. The liquid then flows down the tubular sidewall 252 of the syringe 202, eventually accumulating at the bottom of the syringe 202, thereby filling the syringe from the bottom up as air escapes from the syringe 202 through the flow controller 224 and the connector tubing 220. This flow along the inner surface of the syringe 202 helps reduce turbulence as the liquid fills the syringe 202, which helps reduce the formation of bubbles as the syringe 202 is filled.

[0148] As the syringe 202 is filled, the liquid will eventually reach a level within the syringe 202 where it will flow into the open end 226 of the flow controller 224 and into the connector conduit 220, thereby pre-venting the connector conduit 220. When the connector conduit 220 is fully pre-vented, any additional liquid flow into the syringe 202 will force the float 214 upward against the inner surface of the connector cap 212, thereby stopping the flow of liquid from the fill conduit 208 into the syringe 202. At this point, the pre-vent straw 222 can be removed and the fitting 221 of the connector conduit 220 can be coupled to the patient-side conduit (not shown), and the contents of the syringe 202 can be delivered to the patient via conventional liquid delivery procedures, such as using a powered liquid injector. During the injection procedure of delivering liquid from the syringe 202, the float 214 seats against the distal end of the valve housing 216 to prevent liquid from flowing into the liquid container 201. It should be understood that the rate of liquid flow in the fluid transfer assembly 200 can be optimized by, for example, changing the height between the container and the syringe 202 to increase the head pressure, removing liquid restriction points in the valve area, increasing the syringe neck size, etc.

[0149] Next, see Fig.14, shows a filling adapter 300 according to another alternative example of the present disclosure. The filling adapter 300 can be used in combination with a syringe 302 having a spike 304 coupled thereto via a snap-on connection, a threaded connection, a weld, or the like. The spike 304 has a plurality of liquid openings 305 on its side surface and an air exchange conduit 306 extending therethrough along an axial length. For some examples, the cross-sectional area of ​​the air exchange conduit 306 can be between 8% and 40% smaller than the cross-sectional area of ​​the conduit in fluid communication with the liquid openings 305. The liquid pressure at the opening 305 is higher than the pressure at the air exchange conduit 306 due to the head pressure. Therefore, the liquid in the container will naturally flow through the opening 305. Such an arrangement ensures that the air leaving the conduit 306 will not enter the opening 305 to introduce bubbles into the syringe during the filling process. A bell-shaped flow controller 308 is at the end of the air exchange conduit 306 close to the syringe 302. Although not shown, spike 304 is configured to connect to a container (e.g., Fig.12 304) to induce the flow of liquid from the container into the syringe 302. The liquid in the container is configured to flow into the liquid opening 305 on the spike 304, through the spike 304 and downward around the periphery of the air exchange conduit 306. The air present in the syringe 302 is simultaneously exchanged with the air in the container via the air exchange conduit 306. As the liquid flows along the peripheral surface of the flow controller 308, it reaches the bell-shaped horn portion 310 on the proximal end of the flow controller 308, thereby pushing the liquid toward the ribbed connector 309 at the distal end of the syringe 302. As described above, see Fig.13 As discussed, this combination of the bell-shaped profile of the flow controller 308 and the ribbed connector 309 causes the liquid to fill the syringe 302 according to the Coanda effect. Thus, as the liquid flows down the flow controller 308 and the ribbed connector 309, it is naturally attracted to the inner surface of the syringe 302, which helps reduce turbulence as the liquid fills the syringe 302 and helps reduce bubbles within the syringe 302. For some examples, the ratio of the cross-sectional area of ​​the bell 310 to the cross-sectional area of ​​the internal conduit of the flow controller 308 can be between 5:1 and 20:1. For other examples, the radius of the bell 310 is desirably less than or equal to the radius of the sidewall of the syringe 302 at the transition area between the distal end of the truncated cone and the syringe neck.

[0150] After the syringe 302 is filled with liquid, the spike 304 can be removed from the container and a connector tube (not shown) can be attached thereto via an appropriate connection, such as a snap-on connection. The connector tube can be connected to a patient-side line (not shown), and the contents of the syringe 302 can be delivered to the patient via a liquid delivery procedure, such as using a powered liquid injector.

[0151] See also Figures 15A-15B , shows a fluid transfer assembly 400 according to another example of the present disclosure. The fluid transfer assembly 400 has dual syringes 401, 402. As is known in the art, many injection procedures involve injecting two different liquids (e.g., contrast media and saline) into a patient. The fluid transfer assembly 400 accommodates such procedures by using dual syringes 401, 402. Each syringe 401, 402 is a syringe that is similar to that described herein, for example, according to Figure 12-14 The syringes 401, 402 and spike adapters 403, 404 are configured to be connected to a liquid container (not shown) above the syringes 401, 402. Filling pipes 405, 406 connect the syringes 401, 402 to the corresponding spike adapters 403, 404, wherein each filling pipe 405, 406 has a pipe clamp 407, 408 disposed thereon for selectively stopping or starting the flow of liquid through the filling pipe 405, 406, respectively.

[0152] Each syringe 401, 402 is coupled to a corresponding valve housing 411, 412 having a corresponding connector cap 409, 410. Figure 12-14 The syringes 401, 402 are filled with the corresponding liquids in substantially the same manner as described. Fig.15A As shown, the valve housing 411 is liquid-coupled to a T-connector 413. The T-connector 413 couples the valve housing 411 to a low-pressure connector conduit 414, wherein the connector conduit 414 has a pre-exhaust suction tube 415 connected at its distal end. The T-connector 413 also includes a fitting 419. On the other hand, the valve housing 412 on the syringe 402 is directly coupled to a connector conduit 416, which has a fitting 417 at its distal end.

[0153] In a manner similar to that mentioned above Figure 12-14 After the corresponding syringes 401, 402 are filled in the manner described, the fluid transfer assembly 400 provides that the contents of the syringes 401, 402 can be injected into the patient simultaneously or sequentially through the connector conduit 414. Fig. 15BAfter the syringes 401, 402 are filled, the connector tube 416 and the fitting 417 can be connected to the fitting 419 on the T-connector 413. Through this fluid connection, the corresponding liquids in the syringes 401, 402 can be combined together or flow in sequence during the injection process and provided to the patient via the wet connection with the connector tube 414.

[0154] Fig.16 Another alternative example of the present disclosure is shown. Dual syringes 501, 502 are shown as being fluidly coupled to corresponding spike adapters 505, 506 via corresponding filling conduits 503, 504. The filling procedure may be the same as described above with reference to Figure 12-13 and Figures 15A-15B The invention is basically similar to that described above. After the syringes 501, 502 are filled with appropriate liquids, they can be connected to the Y-shaped connector pipe 510 via corresponding check valve fittings 508, 509. The connector pipe 510 can then be connected to the patient-side pipe 511 at its distal end. Through this fluid connection, the corresponding liquids in the syringes 501, 502 can be combined together or delivered in sequence during the injection process and provided to the patient via a wet connection with the connector pipe 510. Such a configuration can be particularly effective for multi-patient injector applications because the connector pipe 510 can be a disposable connector and the check valve fittings 508, 509 can prevent the two-way flow of liquid and the contamination of the corresponding syringes 501, 502.

[0155] See now Figures 17A-17B , describes a fluid transfer assembly 600 according to another example of the present disclosure. Fig.17A A syringe 601 is shown having a valve housing 603 coupled thereto, wherein the valve housing 603 has a connector cap 604 coupled thereto. A spike adapter 605 is coupled to the connector cap 604, and a low pressure connector conduit 602 is fluidly connected between the valve housing 603 and the connector cap 604, wherein a fitting 606 is configured to provide a removable connection between the connector conduit 602 and the connector cap 604. Fig. 17B The liquid pathways associated with the fluid transfer assembly 600 are provided in greater detail. For example, the spike adapter 605 has a pair of conduits 607, 608. The liquid conduit 607 allows liquid to flow from a container (not shown) coupled to the spike adapter 605 down to a conduit 610 within the connector cap 604. The air conduit 608 allows air to escape from the container as the fluid is directed through the liquid conduit 607. For some examples, the cross-sectional area of ​​the air conduit 608 can be between 8% and 40% smaller than the cross-sectional area of ​​the liquid conduit 607. As shown in FIG. Fig. 17BAs shown, the distal end of the air conduit 608 is positioned away from the distal end of the liquid conduit 607. For some instances, the air conduit 608 can extend 0.15 in. to 0.25 in. farther distally than the liquid conduit 607. In this way, the liquid pressure at the opening of the liquid conduit 607 is higher than the liquid pressure at the air conduit 608 due to the difference in head pressure. Due to this pressure difference, air can be forced to exit the container through the air conduit 607 when the container is filled through the liquid conduit 608. In addition, the introduction of fluid into the first fluid container through the liquid conduit 608 also creates a vacuum in the second fluid container, which "pulls" air from the first fluid container through the air conduit 608 into the second inflow container. When filling the syringe 601, the liquid can flow around the optional float 609 within the valve housing 603 and flow through the passage 620. The liquid can then flow through the flow passage 621 around the periphery of the bell-shaped flow controller 612. As described above, see Fig.12 and 13 As discussed, the shape and size of the flow controller 612 is determined to direct the flow of liquid along the inner surface of the syringe 601 by the Coanda effect when the syringe 601 is filled. The flared portion 616 of the flow controller 612 and the ribbed connector 611 on the distal end of the syringe 601 can also direct such liquid flow. For some examples, the ratio of the cross-sectional area of ​​the flared portion 616 to the cross-sectional area of ​​the flow passage 621 can be between 5:1 and 20:1. For other examples, the radius of the flared portion 616 is desirably less than or equal to the radius of the side wall of the syringe 601 at the transition area between the distal end of the truncated cone and the syringe neck.

[0156] When liquid from the container fills syringe 601, air within syringe 601 is able to pass through passage 615 formed in flow controller 612, which then passes through connector conduit 602 and into conduit 608 of spike adapter 605, whereby air enters the container. When syringe 601 is filled with liquid, the liquid itself enters passage 615 and pre-exhausts connector conduit 602. The liquid is prevented from entering conduit 608 (and thus re-entering the container) via filter 613, at which point connector conduit 602 is pre-exhausted by the liquid. After connector conduit 602 is completely pre-exhausted by liquid, liquid still entering syringe 601 pushes float 609 upward, effectively sealing syringe 601 from receiving more liquid. During the injection procedure in which liquid is delivered from syringe 601, float 609 rests against the distal end of spike adapter 605 to prevent liquid from flowing into the liquid container (not shown).

[0157] After the syringe 601 is filled with contrast media or saline and the connector conduit 602 is fully pre-emptied, the connector conduit 602 can be detached from the connector cap 604 at the fitting 606, and the patient-side connector conduit can then be connected to the fitting 606 so that the contents of the syringe 601 can be delivered to the patient via conventional liquid delivery procedures, such as using a powered liquid injector.

[0158] See also Figures 18A-18E , describes a fluid transfer assembly 700 according to another example of the present disclosure. Many of the components in the system 700 are similar to those described above with reference to Figures 17A-17B Those components of the described system 600 are the same or similar, so repeated components will not be discussed in detail. The fluid transfer assembly 700 has a syringe 701 that is fluidly coupled to a container 702 via two different connector conduits 704, 705. One end of the corresponding connector conduits 704, 705 is coupled to a spike adapter 703 that engages the container 702. The syringe 701 has a valve housing 708 coupled thereto, wherein the valve housing 708 has a connector cover 707 connected thereto. The corresponding connector conduits 704, 705 are coupled to the connector cover 707, and a low-pressure connector conduit 709 is fluidly coupled between the valve housing 708 and the connector cover 707, wherein a fitting 710 is configured to provide a removable coupling between the connector conduit 709 and the connector cover 707. Additionally, a tube clamp 706 (or other appropriate valve) is coupled to the connector conduit 705 so that flow through the connector conduit 705 can be shut off.

[0159] See Figures 18C-18E , showing in more detail the liquid paths associated with the fluid transfer assembly 700. For example, the spike adapter 703 has a plurality of liquid openings 712 extending laterally through the spike adapter 703 and configured to allow liquid to enter the connector conduit 704 from the container 702. The spike adapter 703 also has a conduit 713 configured to provide air communication with the connector conduit 705 and the overhead space of the container 702. The plurality of openings 712 allow liquid to flow downward from the container 702 to the connector cap 707. The openings 712 may have a diameter from 0.01 to 0.10 in. 2 or about 0.06in 2For some examples, the cross-sectional area of ​​conduit 713 can be between 8% and 40% smaller than the cross-sectional area of ​​the conduit in fluid communication with opening 712. When filling syringe 701, liquid is able to flow around optional float 715 within valve housing 708 and into syringe 701 because float 715 is retained on surface 719 within valve housing 708, thereby enabling liquid to flow. Again, as described above with reference to Figure 12-13 As discussed, the flow controller 716 is shaped and sized to direct the flow of liquid along the inner surface of the syringe 701 via the Coanda effect as the syringe 701 is filled.

[0160] When liquid from the container 702 fills the syringe 701, air within the syringe 701 is able to pass through the flow controller 716, which then passes through the connector tube 709 and into the conduit 713 of the spike adapter 703, whereupon the air enters the container 702 ( Fig.18A 716 and the like). When the syringe 701 is filled with liquid, the liquid itself enters the flow controller 716 and pre-exhausts the connector conduit 709. The liquid is prevented from entering the conduit 713 (and therefore re-entering the container) via the filter 717. After the connector conduit 709 is completely pre-exhausted by the liquid, the liquid still entering the syringe 701 pushes the float 715 upward, thereby effectively sealing the syringe 701 to prevent receiving more liquid. During the injection procedure of delivering liquid under pressure from the syringe 701, the float 715 rests on the distal end of the valve housing 708 to prevent liquid from flowing into the liquid container 702. Flow through the conduits 703, 704 can also be prevented by the tube clamp 706.

[0161] See Fig.18D , the openings 712 can be axially spaced relative to each other. When the spike adapter 703 is inserted into the liquid container, the liquid pressure at the openings 712 from the liquid in the container increases from the distal end of the spike adapter 703 toward the proximal end of the spike adapter 703. In this way, the liquid pressure at the distal-most opening 712 will be slightly lower than the liquid pressure at the proximal-most opening 712. Therefore, the liquid in the container will first flow through the proximal-most opening 712 before flowing through the distal opening 712. Such an arrangement ensures that air leaving the conduit 713 during the filling process, for example due to the Venturi effect, will not enter the opening 712 to introduce bubbles into the syringe.

[0162] After the syringe 701 is filled and the connector conduit 709 is fully pre-vented, the connector conduit 709 can be detached from the connector cap 707 at the fitting 710, and the patient-side connector conduit can then be connected to the fitting 710 so that the contents of the syringe 701 can be delivered to the patient via conventional liquid delivery procedures, such as using a powered liquid injector.

[0163] Steering Figures 19A-19B , shows a fluid transfer assembly 800 according to another example of the present disclosure. The fluid transfer assembly 800 has a first container (e.g., a saline bag) 801 and a second container 802 (e.g., a contrast medium bottle) that are liquid-coupled to corresponding first and second syringes 803, 804. The details of how to fill the first and second syringes 803, 804 are substantially similar to those described above with reference to Figures 18A-18E Therefore, further description of the filling process is omitted here. Fig.19A As shown, during the filling process, the low pressure connector conduit 805 forms a passage between the first syringe 803 and the connector conduit leading to the first container 801, while a separate conduit 806 provides a passage between the second syringe 804 and the connector conduit leading to the second container 802. However, see Fig.19B After the first and second syringes 803, 804 are filled with corresponding liquids, the connector tube 806 can be connected to the connector tube 805. Through this fluid connection, the corresponding liquids in the first and second syringes 803, 804 can be combined together or delivered in sequence during the injection process and provided to the patient via the wet connection with the connector tube 805.

[0164] See also Fig. 20 , shows a fluid transfer assembly 900 according to another alternative example of the present disclosure. The fluid transfer assembly 900 has a first container (e.g., a saline bag) 901 and a second container 902 (e.g., a contrast medium bottle) that are fluidically coupled to corresponding first and second syringes 903, 904. Again, the details of how to fill the first and second syringes 903, 904 are substantially similar to those described above with reference to Figures 18A-18E901, and the first and second syringes 903 and 904 are connected to each other. The first and second syringes 903 and 904 are connected to each other by a plurality of means ...

[0165] See now Figures 21A-21F , shows a fluid transfer assembly 1000 according to another example of the present disclosure. Specifically, the fluid transfer assembly 1000 shows more details about the flow controller 1006 retained in the valve housing 1002. Similar to the previous example discussed above, the fluid transfer assembly 1000 has a valve housing 1002, which has a connector cover 1012 coupled thereto, wherein an optional float 1004 is retained therein. Liquid can enter the valve housing 1002 via a connector conduit 1013, which is connected to a container (not shown) positioned above it. The float 1004 allows liquid to pass therethrough by resting on a surface 1005 having a liquid passage therein. The flow controller 1006 is further coupled to a connector conduit 1009, which allows air and / or liquid to pass therethrough. During an injection procedure in which liquid is delivered under pressure from a syringe 1008, the float 1004 rests on the distal end of the valve housing 1002 to prevent liquid from flowing into the liquid container.

[0166] As discussed above, the size and shape of the flow controller 1006 is determined to guide the liquid flowing thereon to adhere to the inner surface of the syringe 1008 according to the Coanda effect. In order to achieve flow according to the Coanda effect, it may be advantageous to provide a plurality of ribs or contours on one or both of the outer surfaces of the flow controller 1006 and the ribbed connector 1010. For example, Figures 21C-21D The ribbed connector 1010 is shown, wherein a plurality of rounded ribs 1011 are formed on the inner surface thereof. When the liquid passes through the ribbed connector 1010, the ribs 1011 can guide the liquid flow so as to cause the liquid to adhere to the inner surface of the syringe 1008. Similarly, the size and shape of the flow controller 1006 can be determined to further induce such liquid flow. Fig.21EAs shown, the flow controller 1006 may have a plurality of ribs 1015 that similarly promote uniform liquid flow. The ribs 1015 may have equal or unequal angular spacing around the longitudinal axis of the flow controller 1006. The ribs 1015 coupled to the flared end 1007 may further promote liquid adhesion to the inner surface of the syringe 1008. Also, although the ribbed connector 1010 is shown as having a plurality of rounded ribs 1011, it may also be advantageous to have ribs of different shapes to control flow. For example, as Fig.21F As shown, the ribbed connector 1020 can have a plurality of square ribs 1021 having flared tips for promoting liquid flow along the inner surface of the syringe 1008. For some examples, the ratio of the cross-sectional area of ​​the flared tip 1007 to the cross-sectional area of ​​the internal conduit of the flow controller 1006 can be between 5:1 and 20:1. For other examples, the radius of the flared tip 1007 is desirably less than or equal to the radius of the side wall of the syringe 1008 at the transition area between the distal end of the truncated cone and the syringe neck.

[0167] Next, see Figures 22A-22D , shows a fluid transfer assembly 1200 according to another example of the present disclosure. The fluid transfer assembly 1200 has a syringe 1201 and a spike adapter 1202, which is configured to be connected to a liquid container (not shown) above the syringe 1201. The spike adapter 1202 has a vent 1203 to allow air to enter the liquid container during the filling process. A filling conduit 1204 connects the syringe 1201 to the spike adapter 1202. A valve housing 1205 is coupled to the open end of the syringe 1201, wherein the valve housing 1205 has a connection cap 1206 thereon and an optional float 1210 retained therein. The valve housing 1205 is further configured to be liquid-coupled to a pre-exhaust suction tube 1207 via a fitting 1208. When the pre-exhaust suction tube 1207 is removed, a separate conduit (not shown) can be coupled to the valve housing 1205 to achieve a final fluid connection with the patient after pre-exhaust.

[0168] The valve housing 1205 is shown coupled to the syringe 1201, with the fill conduit 1204 being liquid coupled to the valve housing 1205 via a connecting cap 1206. A bell-shaped flow controller 1212 is also within the valve housing 1205. Also, the bell-shaped profile of the surface of the flow controller 1212 directs the liquid to flow along the inner wall of the syringe 1201 according to the Coanda effect. The central opening in the flow controller 1212 provides a wide passage for air to flow from the syringe 1201 to the pre-exhaust conduit 1207, thereby reducing the speed at which the air moves across the air / liquid interface. In this way, the slow-moving air is less likely to pull the liquid in the distal direction, for example, under the Bernoulli effect.

[0169] See now Figures 23A-23D , shows a fluid transfer assembly 1300 according to another example of the present disclosure. The fluid transfer assembly 1300 has a syringe 1301, a container 1302, and a spike adapter 1303, which is configured to directly connect the syringe 1301 and the container 1302 to each other. Fig. 23B , spike adapter 1303 has a spike 1310 that is capable of puncturing a septum or other sealing component of container 1302. The spike 1310 has two passages formed therethrough, one passage being in fluid connection with syringe 1301 and the other passage enabling air to be discharged into container 1302 through a vent conduit 1306 formed on spike adapter 1303, wherein vent conduit 1306 is coupled to vent cap 1307. When liquid passes through spike 1310 from container 1302, for example during a vacuum filling procedure, it contacts flow controller 1308. As described in detail in the examples above, flow controller 1308 is formed to direct the flow of liquid along the inner surface of syringe 1301 during the filling process. Specifically, as Fig. 23B and Fig.23D As shown, the flow controller 1308 can have an internal opening 1315 formed therein, wherein any liquid entering the flow controller 1308 is pushed to flow downward along the peripheral surface of the flow controller 1308, thereby better guiding the liquid to flow along the inner surface of the syringe 1301.

[0170] Although the flow controller 1308 is shown as having an internal opening 1315 formed therein, the shape and profile of the flow controller according to the present disclosure are not limited thereto. Figures 24A-24B , Figures 25A-25B and Figures 26A-26B A plurality of alternative flow controllers according to a plurality of alternative examples of the present disclosure are shown. Specifically, Figures 24A-24BA flow controller 1312 is shown having a solid bell-shaped member 1316 extending thereunder, wherein the bell-shaped member 1316 is configured to direct the flow of liquid along the inner surface of the syringe 1301 . Figures 25A-25B A flow controller 1320 is shown having an opening 1321 therein, wherein a bottom portion of the flow controller 1320 has a plurality of openings 1322 formed therein to allow liquid to pass therethrough at or near the inner surface of the syringe 1301. In addition, Figures 26A-26B A flow controller 1328 is shown having an arcuate insert 1330 retained therein for urging liquid therethrough to flow along the inner surface of the syringe 1301. The insert 1330 may be made of an elastomeric material so that the opening formed by deflection of at least a portion of the insert 1330 due to liquid flow may be adjusted.

[0171] See now Figures 27A-27G , shows a fluid transfer assembly 1400 according to another example of the present disclosure. Many aspects of the fluid transfer assembly 1400 are similar to those discussed previously with reference to earlier fluid transfer assemblies, but the fluid transfer assembly 1400 utilizes a spool valve 1415 to enable or disable flow to / from a syringe 1401, as will be discussed herein.

[0172] See Figures 27A-27G, the fluid transfer assembly 1400 has a container 1402 and a syringe 1401, wherein the container 1402 and the syringe 1401 are fluidly connected via corresponding dual connector conduits 1403, 1404. A valve housing 1406 is connected to the syringe 1401, wherein the valve housing 1406 has a flow controller 1410 therein, and has a vent cap 1412 configured to allow air to go to / leave the syringe 1401, and a fitting for fluid communication with a low pressure connector conduit 1405. The valve housing 1406 is further fluidly connected to a spool valve 1415, such that the spool valve 1415 enables or inhibits the flow of liquid passing through the valve housing 1406 and into the syringe 1401. More specifically, the spool valve 1415 is fluidly connected to the two connector conduits 1403, 1404. During the syringe filling operation, one end of the connector tube 1405 is connected to the valve housing 1406, and the second end of the connector tube 1405 having the fitting 1408 is connected to the spool valve 1415 at the fitting 1409. The valve member 1416 is located within the spool valve 1415, and the valve member is configured to be longitudinally biased to the "closed" position by a spring 1417 or other biasing member. However, when the fitting 1408 of the connector tube 1405 is connected to the fitting 1409, a portion of the fitting 1408 pulls the valve member 1416 from the "closed" position ( Fig.27D Push to the "open" position ( Fig.27B 1404 to the container 1402. In this way, the fluid transfer assembly 1400 is a closed system in which no air is introduced from outside the fluid transfer assembly 1400. Instead, the air exchange between the container 1402 and the syringe 1401 during the filling operation of the syringe 1401 is accomplished by the connector tubes 1403, 1404, and 1405, and only the sterile air within the fluid transfer assembly 1400 is exchanged. The closed system of the fluid transfer assembly 1400 may be suitable for transferring liquids in situations where it is desired to prevent the liquids from being contaminated by external air, such as by chemicals.

[0173] See also Figures 27C-27D When the fitting 1408 is removed from the spool valve 1415, the valve member 1416 is no longer pushed against the spring 1417. Thus, the spring 1417 biases the valve member 1416 to the "closed" position ( Fig.27D ), thereby preventing liquid from flowing from connector tube 1403 into syringe 1401 and also blocking air or liquid from passing out of connector tube 1404.

[0174] See also Figures 28A-28B , shows a fluid transfer assembly 1500 according to another aspect of the present disclosure. Many aspects of the fluid transfer assembly 1500 are similar to those discussed above with respect to the fluid transfer assembly 1400, but the fluid transfer assembly 1500 does not require the use of auxiliary tubing (e.g., a syringe 1501 or a container 1502) extending between the syringe 1501 and the container 1502. Figures 27A-27G Pipe 1404 in), as described herein.

[0175] See Figures 28A-28B , the fluid transfer assembly 1500 has a container 1502 and a syringe 1501, wherein the container 1502 and the syringe 1501 are fluidly connected via a single connector conduit 1503. The connector conduit 1503 is fluidly connected to the container 1502 via a venting connector 1522, and the venting connector has an air filter therein to allow air in the container 1502 to be exhausted during the transfer of liquid between the container 1502 and the syringe 1501. A valve housing 1506 is coupled to the syringe 1501, wherein the valve housing 1506 has a flow controller 1510 therein and has a fitting for fluid connection with a low-pressure connector conduit 1505. The valve housing 1506 is further fluidly connected to a spool valve 1515, such that the spool valve 1515 enables or inhibits the flow of liquid passing through the valve housing 1506 and into the syringe 1501. More specifically, the spool valve 1515 is fluidly connected to the connector conduit 1503. During the syringe filling operation, one end of the connector conduit 1505 is connected to the valve housing 1506, and the second end of the connector conduit 1505 having the fitting 1508 is connected to the slide valve 1515 at the fitting 1509. A valve member 1516 is located within the slide valve 1515, and the valve member is configured to be longitudinally biased to a "closed" position by a spring 1517. However, when the fitting 1508 of the connector conduit 1505 is connected to the fitting 1509, a portion of the fitting 1508 pushes the valve member 1516 to an "open" position, thereby allowing liquid to flow from the connector conduit 1503 into the syringe 1501. The valve member 1516 can be solid or hollow. In the hollow configuration, the valve member 1516 can allow air to pass through the inner portion of the valve 1515 while allowing the liquid flowing through the connector conduit 1503 and entering the syringe 1501 to pass on its outer surface.

[0176] In addition to the valve member 1516 allowing liquid to pass between the container 1502 and the syringe 1501 when in the "open" configuration, the valve member 1516 also enables air to flow from the syringe 1501 through the connector conduit 1505 and out of the vent filter 1521 located on the pre-exhaust line 1520 connected to the slide valve 1515. Specifically, during the process of liquid being transferred from the container 1502 to the syringe 1501, air escapes from the syringe 1501 through the connector conduit 1505. The air filter 1521 (which can be, for example, a 0.2 micron air filter) allows the escaped air to be discharged into the atmosphere. When the fitting 1508 is removed from the slide valve 1515, the valve member 1516 is no longer pushed against the spring 1517. Thus, the spring 1517 biases the valve member 1516 to the "closed" position, thereby preventing liquid from flowing from the connector conduit 1503 into the syringe 1501. In this “closed” position, the valve member 1516 may also block air or liquid from leaving the air filter 1521 , but it may alternatively allow the air passage to remain open when disconnected from the connector conduit 1505 .

[0177] See also Fig.29 , shows an injector 1600 according to another aspect of the present disclosure. The injector 1600 is configured to inject a flexible rolling diaphragm (e.g. Figure 2A The rolling diaphragm syringe 12a) shown in is received in the internal space of the syringe 1600. The syringe 1600 has a base adapter 1601 and a connector 1603 at its distal end, the base adapter having a plunger 1604 arranged therein. The syringe tip 1602 is configured to be removably connected to the connector 1603 via, for example, a threaded connection. The syringe tip 1602 is desirably a disposable single-use item. However, the base adapter 1601 is a multiple-use item that can be used between many procedures and / or patients. Thus, instead of an entire syringe assembly for a single use (as is currently common), the syringe 1600 makes it possible to replace only the syringe tip 1602 between multiple uses. In addition, different types of syringe tips can be used for one type of base adapter.

[0178] See also Figures 30A-30C , shows a fluid transfer assembly 10 according to another example of the present disclosure. The fluid transfer assembly 10 is configured to facilitate the transfer of liquid from a second liquid container such as a bottle or bag (not shown) to a first liquid container (see, for example, Figure 2A In other examples, the first liquid container may be a syringe 12a as described herein. Figure 2B The syringe 12b is described.

[0179] Continue to see Figures 30A-30C, the fluid transfer assembly 10 includes a filling adapter 32 that is configured to facilitate the transfer of liquid between the two liquid containers, such as from the second liquid container to the syringe 12a. The filling adapter 32 can be removably connectable to the syringe 12a, such as on the syringe neck 22 of the syringe 12a. In some examples, the filling adapter 32 can be non-removably connected to the syringe 12a, such as being integrally formed therewith or being non-removably attached thereto (e.g., by adhesive, welding, interference fit, or other mechanical connection means). The filling adapter 32 can have an integral, one-piece structure, or it can be formed of two or more parts that are removably or non-removably coupled together. In a number of different aspects, the filling adapter 32 can be between 2 mL / s and 20 mL / s of liquid flow when filling the syringe 12a.

[0180] See also Fig. 30C , the filling adapter 32 has a substantially cylindrical body 56 that is configured to be received within the open distal end 23 of the syringe neck 22. A flange 57 extends radially outward from the body 56 at the distal end 60. In some examples, the outer diameter of the flange 57 can substantially correspond to the outer diameter of the syringe neck 22, so that the filling adapter 32 is flush with the syringe neck 22. In other examples, the outer diameter of the flange 57 can be greater than or less than the outer diameter of the syringe neck 22. The longitudinal length of the body 56 along the longitudinal axis 58 can correspond to the longitudinal length of the syringe neck 22, so that the proximal end 62 of the filling adapter 32 terminates at the proximal end of the syringe neck 22 and before the syringe sidewall 20 transitions from the syringe neck 22 to the tapered portion 33. In some examples, the longitudinal length of the body 56 can be longer or shorter than the transition point where the syringe sidewall 20 transitions from the syringe neck 22 to the tapered portion 33. In a number of different examples, the longitudinal length of the body 56 can be between 6 mm and 100 mm.

[0181] The filling adapter 32 can be sized so that it fits snugly within the open distal end 23 of the syringe neck 22. For example, the outer sidewall 66 of the filling adapter 32 can engage with the inner sidewall of the syringe neck 22 due to an interference fit between the outer sidewall 66 of the filling adapter 32 and the inner sidewall 26 of the syringe neck 22. The filling adapter 32 can be removably or non-removably engaged with the syringe neck 22. In some examples, the filling adapter 32 and the syringe neck 22 can be removably or non-removably connected to each other by clips, fasteners, adhesives, welding, or other mechanical connection means. In some examples, the outer surface of the body 56 can have one or more recesses 59 for facilitating the insertion of the filling adapter 32 into the open distal end 23 of the syringe neck 22. In a number of different examples, the outer diameter of the body 56 of the filling adapter can be between 2.6 mm and 26 mm.

[0182] Continue to see Fig. 30C , the filling adapter 32 has a central hole 61 extending through the body 56 along the longitudinal axis 58. The central hole 61 is configured to allow fluid communication between the second liquid container and the interior of the syringe 12a. In some examples, the central hole 61 can have a uniform diameter throughout its length. In other examples, at least a portion of the central hole 61 can narrow or widen in a direction from the distal end 60 to the proximal end 62 of the body 56. The angled portion 63 of the central hole 61 can widen in a direction from the distal end 60 to the proximal end 62 of the body 56, such as Fig. 30C In some examples, the angle of the angled portion 63 can correspond to the angle of the tapered portion 33 of the syringe 12a. In other examples, the angle of the angled portion 63 can have a greater or lesser angle than the angle of the tapered portion 33 of the syringe 12a. In a number of examples, the angle of the angled portion 63 relative to the longitudinal axis of the body 56 can be between 10 and 80 degrees.

[0183] One or more slots 65 may extend through the sidewall of the body 56. In some examples, the plurality of slots 65 may extend through the sidewall of the body 56 with equal or unequal angular intervals therebetween. The slots 65 may be provided at the same axial position relative to each other, or one or more of the slots 65 may be axially offset relative to the remaining slots 65. In some examples, a shoulder 67 may protrude radially inward from the inner surface of the central hole 61. The shoulder 67 may be located proximal or distal to the one or more slots 65. The shoulder 67 may be continuous or discontinuous in the circumferential direction of the central hole 61. The slot 65 and / or the shoulder 67 interrupt the flow of fluid along the inner sidewall of the central hole 61. In this way, the slot 65 and / or the shoulder 67 assist in directing the fluid to flow through the filling adapter 32 toward the central portion of the hole 61 and away from the inner sidewall of the hole 67, so that the fluid can flow through the flow controller 69, as described herein.

[0184] Continue to see Fig. 30C , the filling adapter 32 can have a flow controller 69 disposed within the central hole 61. The flow controller 69 can be positioned at the proximal end 62 of the body 56. In some examples, the flow controller 69 is composed of one or more spokes 73 ( Fig.30D ) is connected to the inner surface of the central hole 61. Fig.30D As shown, each of the spokes 73 has a first end 75 connected to the body 56 of the filling adapter 32 and a second end 77 connected to the flow controller 69. The gap 79 between the body 56 of the filling adapter 32 and the flow controller 69 is configured to allow liquid to flow therethrough and into the interior of the syringe 12a.

[0185] The flow controller 69 can be positioned so that the outer edge of the flow controller 69 is aligned with the distal end of the angled portion 63. In this manner, liquid deflected by the flow controller 69 will be deflected toward the angled portion 63. As described herein, due to the characteristics of the Coanda effect, the liquid will be attracted to the angled surface of the angled portion 63 of the filling adapter 32 and will continue to flow down the inside wall of the syringe 12a.

[0186] See also Fig.30D And continue to see Fig. 30C, the flow controller 69 can have a curved distal surface 81 configured to divert liquid flowing onto the flow controller 69 in a radially outward direction toward the gap 79. The distal surface 81 can have a convex shape having a uniform or non-uniform curvature. In some examples, the flow controller 69 can have a curved proximal surface 83. The curved proximal surface 83 can have a convex shape having a protrusion 89 in a central portion thereof. The protrusion 89 can protrude from the proximal surface 83 in a proximal direction. In some examples, such as Figures 31A-31B As shown, the central portion of the distal surface 81 can have a flow diverter 87. The flow diverter 87 can extend distally relative to the distal surface 81. The flow diverter 87 can be configured to divert the liquid flowing through the central hole 61 of the filling adapter 32 toward the outer edge of the flow controller 69, so that the liquid flows through the gap 79.

[0187] In some examples, the syringe neck 22 can have a sealing member, such as an O-ring 91. The O-ring 91 is configured to sealingly engage a cap (not shown) that is removably connectable to the syringe neck 22 of the syringe 12a. The outer portion of the syringe neck 22 can have a flange 150 that is configured to interact with the cap for removably retaining the cap with the syringe neck 22. In some examples, the filling adapter 32 can be removably or non-removably connected to the cap so that the filling adapter 32 can be removed from the syringe 12a by removing the cap. In other examples, the filling adapter 32 is provided separately from the cap so that the filling adapter 32 remains connected to the syringe 12a when the cap is removed from the syringe 12a.

[0188] During the filling process, liquid from a second liquid container (not shown) above the syringe 12a is fed by gravity or by vacuum to the filling adapter 32. As the liquid flows through the central hole 61 of the filling adapter 32, the liquid contacts the flow controller 69. Due to the convex shape of the distal surface 81 of the flow controller 69, the liquid will be directed radially outward to flow through the gap 79. Due to the angled portion 63 of the bell shape, the liquid is naturally attracted to flow along the tapered portion 33 of the syringe 12a and then down the sidewall 20. This flow along the inner surface of the syringe 12a helps to reduce turbulence as the liquid fills the syringe 12a, which helps to reduce the formation of bubbles when filling the syringe 12a. At the same time, air is expelled from the interior of the syringe and escapes through the gap 79 into the second fluid container. The air / liquid exchange within the syringe 12a occurs substantially simultaneously through the central hole 61 without any flow wandering or gurgling due to uneven flow characteristics.

[0189] See also Figures 32A-32D , a cap 122 may be provided on the syringe neck 22 of the syringe 12a. The cap 122 is configured to close the distal end 18 of the syringe 12a. The cap 122 is removably connected to the syringe neck 22 of the syringe 12a, for example, via a threaded connection, a snap-fit ​​connection, a friction fit connection, or any other suitable removable connection mechanism. In some examples, the filling adapter 32 may be removably or non-removably connected to the cap 122, such that the filling adapter 32 can be removed from the syringe 12a by removing the cap 122. In other examples, the filling adapter 32 is provided separately from the cap 122, such that the filling adapter 32 remains connected to the syringe 12a when the cap 122 is removed from the syringe 12a.

[0190] The cap 122 includes a port 124 configured to be connected to a line in fluid communication with a second liquid container (not shown) to fill the syringe 12a with liquid from the second liquid source. In other examples, the port 124 can be configured to be connected to a line connected to a cannula, a needle, or other liquid delivery connection (not shown) inserted into the patient's body at a site of access to a blood vessel so as to deliver liquid from the syringe 12a to the patient.

[0191] In some examples, the port 124 can be provided on a radial side of the cap 122. A high cracking pressure valve (not shown) can be provided on the cap 122 for allowing liquid to flow through the cap 122 into the syringe 12a when a predetermined cracking pressure is reached or exceeded, while preventing flow through the cap 122 when the head pressure is less than the cracking pressure. In one example, the high cracking pressure valve can be a slit valve or other conventional cracking pressure valve. The cap 122 can have at least one gasket around the inner surface of the cap 122 for engaging the outer surface 24 of the syringe neck 22. In some examples, the gasket (e.g., an O-ring 91) can be provided on the outer surface 24 of the syringe neck 22. The O-ring 91 is configured to create a liquid-tight seal between the outer surface 24 of the syringe neck 22 and the inner surface of the cap 122. See Figures 32A-32B , the distal surface 126 of the cover 122 can be configured as a substantially flat surface.

[0192] Continue to see Figures 32A-32B , the cap 122 is removably connectable to the syringe 12a by a connection mechanism 140. The connection mechanism 140 is configured to securely retain the cap 122 (e.g., Fig.32B 12a) and allows the cap 122 to be disconnected from the syringe neck 22 of the syringe 12a by rotating the cap 122 about its longitudinal axis relative to the syringe 12a. The connection mechanism 140 has one or more tabs 142 on the cap 122, which interact with one or more cams 144 on the syringe 12a. When the cap 122 is connected to the syringe 12a, the rotation of the cap 122 relative to the syringe 12a causes the one or more tabs 142 to interact with the one or more cams 144, thereby deflecting the tabs 142 radially outward so that the cap 122 can be removed from the syringe 12a.

[0193] See also Fig.32C, the tabs 142 protrude in the proximal direction from a skirt 146 that extends around the outer circumference of the cap 122. The tabs 142 may be spaced apart from each other at equal or unequal angular intervals around the skirt 146. Each tab 142 has a first end 142a connected to the skirt 146 and a second end 142b protruding proximally from the skirt 146. The second end 142b of each tab 142 may deflect relative to the first end 142a when the tab 142 engages the cam 144. The second end 142b of each tab 142 has a recess 148 that is configured to engage a flange 150 that extends radially outward from the outer surface 24 of the syringe neck 22. The flange 150 may extend around a portion or the entire circumference of the syringe neck 22. When engaged with the flange 150, the recess 148 prevents the cap 122 from being removed from the syringe 12a. Each tab 142 may have a chamfered edge 152 configured to engage a distal surface of the flange 150 to deflect the tab 142 in a radially outward direction when the cap 122 is being coupled to the syringe neck 22. After the chamfered edge 152 clears the flange 150, each tab 142 may deflect back to engage the recess 148 with the flange 150, thereby coupling the cap 122 to the syringe neck 22 of the syringe 12a.

[0194] See also Fig.32D , the cam 144 is positioned proximal to the flange 150. In some examples, a plurality of cams 144 are spaced apart from one another around the outer circumference of the syringe neck 22 below the flange 150. The cams 144 may be spaced apart from one another at equal or unequal angular intervals. For example, Fig.32D Shown is a syringe 12a with four cams 144, which are spaced 90 degrees apart from each other. In this way, a rotation of the cover 122 less than 90 degrees causes the tab 142 to engage the cam 144 to disconnect the cover 122 from the syringe 12a. Each cam 144 has a pair of ramp surfaces 144a, 144b, which meet together at an edge 154. In some instances, the edge 154 can terminate at the outer end of the flange 150. The ramp surfaces 144a, 144b define an engagement surface for contacting the second end 142b of the tab 142 when the cover 122 is to be disconnected from the syringe 12a.

[0195] In order to remove the cap 122 from the syringe 12a, the cap 122 can be rotated about its longitudinal axis in a first direction (e.g., clockwise) or a second direction (e.g., counterclockwise) relative to the syringe longitudinal axis. During such rotational movement of the cap 122, the second end 142b of each tab 142 engages one of the ramp surfaces 144a, 144b of each cam 144. Due to the angled configuration of the ramp surfaces 144a, 144b, continued rotation of the cap 122 causes the second end 142b of the tab 142 to deflect relative to the first end 142a (and the flange 150), thereby allowing the tab 142 to move over the flange 150. In this way, the cap 122 can be disconnected from the syringe neck 22 by simply rotating the cap 122 relative to the syringe 12a.

[0196] See also Figures 33A-33C , shows a fluid transfer assembly 10 according to another example of the present disclosure. Figures 33A-33C The components of the fluid transfer assembly 10 shown in FIG. 1 are substantially similar to those described herein with reference to FIG. Figures 32A-32D The components of the fluid transfer assembly 10 described above. Figures 32A-32D The discussion of the fluid transfer assembly 10 shown in FIG. 1 may be applied to Figures 33A-33C , so only the relative differences between the two liquid transport assemblies 10 are discussed below.

[0197] The cap 122 is removably connectable to the syringe 12a by a connection mechanism 140. In some examples, the filling adapter 32 may be removably or non-removably connected to the cap 122 such that the filling adapter 32 may be removed from the syringe 12a by removing the cap 122. In other examples, the filling adapter 32 is provided separately from the cap 122 such that the filling adapter 32 remains connected to the syringe 12a when the cap 122 is removed from the syringe 12a. The connection mechanism 140 is configured to securely retain the cap 122 connected to the syringe neck 22 of the syringe 12a and allow the cap 122 to be disconnected from the syringe neck 22 of the syringe 12a by rotating the cap 122 about its longitudinal axis relative to the syringe 12a to a removal position, where the cap 122 can be separated from the syringe 12a by axial movement of the cap 122 relative to the syringe 12a. The connection mechanism 140 has one or more tabs 142 on the cap 122 that interact with a flange 150 on the syringe 12a.

[0198] See also Fig.33C, the one or more tabs 142 on the cap 122 protrude in the proximal direction from a skirt 146 that extends around the outer circumference of the cap 122. The tabs 142 may be spaced apart from each other at equal or unequal angular intervals around the skirt 146. Each tab 142 has a first end 142a connected to the skirt 146 and a second end 142b protruding proximally from the skirt 146. Desirably, the second end 142b of each tab 142 is deflectable relative to the first end 142a. The second end 142b of each tab 142 has a recess 148 that is configured to engage a flange 150 ( Fig.33B shown).

[0199] See also Fig.33B , the flange 150 can extend around a portion of the outer circumference of the syringe neck 22. In some examples, the flange 150 can be formed as a continuous member having a first end and a second end separated by a gap 160. In other examples, the flange 150 can be formed by a plurality of segments separated from each other by two or more gaps 160. For example, the flange 150 can have two flange segments 150a, 150b separated by two gaps 160. The flange segments 150a, 150b can have equal or unequal lengths and can be separated by gaps 160 having equal or unequal widths. Each gap 160 defines a removal position at which the tabs 142 can be aligned to remove the cap 122 from the syringe neck 22, as discussed herein. Desirably, the number of tabs 142 corresponds to the number of gaps 160. When engaged with the flange 150, the recess 148 prevents the cap 122 from being removed from the syringe 12a. Each tab 142 may have a chamfered edge 152 configured to engage a distal surface of the flange 150 to deflect the tab 142 in a radially outward direction when the cap 122 is being connected to the syringe neck 22. After the chamfered edge 152 clears the flange 150, each tab 142 may deflect back to engage the recess 148 with the flange 150, thereby connecting the cap 122 to the syringe neck 22 of the syringe 12a.

[0200] To remove the cap 122 from the syringe 12a, the cap 122 can be rotated about its longitudinal axis in a first direction (e.g., clockwise) or a second direction (e.g., counterclockwise) relative to the syringe longitudinal axis. During such rotational movement of the cap 122, the tab 142 can be rotated to the removal position by aligning the tab 142 with the gap 160 between the flange sections 150a, 150b. When the cap 122 is rotated to the removal position, the gap 160 creates a clearance space for the tab 142 to pass over the flange sections 150a, 150b. The cap 122 can be disconnected from the syringe neck 22 by axially rotating the cap 122 relative to the syringe 12a.

[0201] See also Figures 34A-34B , shows a filling adapter 32 according to another example of the present disclosure. The filling adapter 32 is configured to facilitate the transfer of liquid from a second liquid container, such as a bottle or bag (not shown), to a first liquid container, such as a syringe 12a. The components of the filling adapter 32 shown in FIG. 34 are substantially similar to those described herein. Figures 30A-31B The components of the filler adapter 32 are described except as noted above. Figures 30A-31B The discussion of the filling adapter 32 shown in FIG. 34 is applicable to the example shown in FIG. 34 , so only the relative differences between the two filling adapters 32 are discussed here.

[0202] The size of the filling adapter 32 is determined so that it fits tightly within the open distal end of the syringe neck 22, for example, due to the engagement of the outer sidewall of the filling adapter 32 with the inner sidewall of the syringe neck 22. The body 56 of the filling adapter 32 has a central hole 61 extending along the longitudinal axis. The central hole 61 is configured to allow liquid communication between the second liquid container and the interior of the syringe 12a. The hole 61 has an angled portion 63 that widens in the direction from the distal end 60 to the proximal end 62 of the body 56. A sealing lip 99 can protrude radially inward from the inner surface of the central hole 61. The sealing lip 99 can be positioned distal to the angled portion 63. It is desirable that the sealing lip 99 is continuous in the circumferential direction of the central hole 61. In some examples, the sealing lip 99 can be made of the same or different material as the body 56. For example, the sealing lip 99 can be made of a flexible elastomeric material, while the body 56 is made of a rigid plastic material.

[0203] The filling adapter 32 has a flow controller 69 arranged in the central hole 61. The flow controller 69 can be positioned at the proximal end 62 and connected to the inner surface of the central hole 61 by one or more elastic elements 101. Each of the elastic elements 101 has a first end 103 connected to the body 56 of the filling adapter 32 and a second end 105 connected to the flow controller 69. The flow controller 69 is axially movable in the direction of the longitudinal axis due to the flow of liquid in the direction from the distal end 60 to the proximal end 62. The elastic element 101 biases the flow controller 69 against the sealing lip 99 when there is no liquid flow. In this way, the flow controller 69 and the sealing lip 99 define a seal to prevent liquid from dripping between the flow controller 69 and the sealing lip 99. Therefore, the filling adapter 32 can be removed from the syringe 12a without spilling any liquid that may remain in the filling adapter 32. In some examples, the filling adapter 32 may be removably or non-removably connected to the cap 122 such that removing the cap 122 from the syringe 12a also removes the filling adapter 32 .

[0204] During the vacuum filling procedure, for example, when the end wall 30 of the syringe 12a is withdrawn in the proximal direction by the drive member of the liquid injector (not shown), the vacuum generated in the internal volume 28 of the syringe 12a pulls the flow controller 69 in the proximal direction against the restoring force of the elastic element 101. In other examples, once the filling adapter 32 is connected to the second container, the liquid pressure generated by the liquid head height in the second container pulls the flow controller 69 in the proximal direction against the restoring force of the elastic element 101. Fig.34B The movement of the flow controller 69 in the proximal direction causes it to move away from the sealing lip 99, thereby opening a gap 79 between the inner circumference of the sealing lip 99 and the outer circumference of the flow controller 69. Fig.34B 79. The flow controller 69 may have a curved distal surface configured to divert liquid flowing onto the flow controller 69 in a radially outward direction toward the gap 79. In this way, the liquid may flow through the gap 79 into the interior volume 28 of the syringe 12a. As described herein, due to the characteristics of the Coanda effect, the liquid will be attracted to the angled surface of the angled portion 63 of the filling adapter 32 and will continue to flow down the inside wall of the syringe 12a. This flow along the inside surface of the syringe 12a helps reduce turbulence as the liquid fills the syringe 12a, which helps reduce the formation of bubbles as the syringe 12a is filled.

[0205] The flow controller 69 is Fig.34BThe proximal movement in the direction of arrow A can move the end wall 30 (or Figure 2B The size of the gap 79 can be controlled in this way to make the gap 79 wider or narrower, thereby optimizing the liquid flow generated by the characteristics of the Coanda effect.

[0206] Although several examples of syringes, adapters, and connection systems and methods for use in medical fluid delivery systems are shown in the drawings and described in detail above, other examples will be clear to those skilled in the art and readily implemented without departing from the scope and spirit of the present disclosure. For example, it should be understood that the present disclosure contemplates that, to the extent possible, one or more features of any example may be combined with one or more features of any other example. Therefore, the foregoing description is intended to be illustrative and not restrictive.

Claims

1. A syringe for a powered medical fluid injector, the syringe comprising: a proximal end, a frustoconical distal end, and a cylindrical sidewall extending between the proximal end and the distal end; a nozzle at a distal portion of the frustoconical distal end of the syringe, the nozzle having a through hole providing fluid communication between an interior volume of the syringe and a medical connector configured to connect to the nozzle; as well as a plurality of longitudinal ribs formed on an inner surface of the mouth; wherein the plurality of longitudinal ribs direct the medical fluid to flow along the inner surface of the frustoconical distal end and along the inner surface of the cylindrical sidewall of the syringe under the Coanda effect; and The proximal end refers to the portion of the syringe that is closest to the injector when the syringe is oriented to be connected to the injector, and the distal end refers to the portion of the syringe that is farthest from the injector when the syringe is oriented to be connected to the injector.

2. The syringe of claim 1, wherein the plurality of longitudinal ribs are configured to enhance surface adhesion of the medical fluid to the inner surface of the frustoconical distal end and along the inner surface of the cylindrical sidewall of the syringe.

3. The syringe of claim 1 or 2, wherein the plurality of longitudinal ribs comprises a plurality of rounded ribs.

4. The syringe of claim 1 or 2, wherein the plurality of longitudinal ribs comprises a plurality of square ribs.

5. The syringe of claim 1 or 2, wherein the plurality of longitudinal ribs extend proximally from the inner surface of the distal end of the mouth to at least a portion of the inner surface of the frustoconical distal end.

6. The syringe of claim 1 or 2 further comprising a flow controller extending through the inner bore of the mouth.

7. The syringe of claim 6, wherein the flow controller is sized and shaped to direct the flow of the medical fluid along the inner surface of the frustoconical distal end and along the interior surface of the cylindrical sidewall of the syringe.

8. The syringe of claim 7, wherein the flow controller directs the medical fluid to flow between the plurality of longitudinal channels between the plurality of longitudinal ribs.

9. The syringe of claim 6, wherein the flow controller comprises a plurality of flow control ribs having equal or unequal angular spacings around a longitudinal axis of the flow controller, wherein the plurality of flow control ribs are on a radially outer surface of the flow controller.

10. The syringe and connector assembly includes: A syringe, the syringe comprising: a proximal end, a frustoconical distal end, and a cylindrical sidewall extending between the proximal end and the distal end; a nozzle at a distal portion of the frustoconical distal end of the syringe, the nozzle having a through hole providing fluid communication between an interior volume of the syringe and a medical connector configured to connect to the nozzle; and a plurality of longitudinal ribs formed on an inner surface of the mouth; and a connector comprising a flow controller disposed within a central bore of the connector, wherein the connector is connected to the distal end of the nozzle and the central hole provides fluid communication between the interior volume of the syringe and the tubing element, and wherein the plurality of longitudinal ribs direct the medical fluid from the fluid path of the connector to flow along the inner surface of the frustoconical distal end and along the inner surface of the cylindrical sidewall of the syringe under a Coanda effect; and The proximal end refers to the portion of the syringe that is closest to the injector when the syringe is oriented to be connected to the injector, and the distal end refers to the portion of the syringe that is farthest from the injector when the syringe is oriented to be connected to the injector.

11. The syringe and connector assembly of claim 10, wherein the tubing element is selected from a spike assembly directly connected to the connector, a fill conduit connected to the spike assembly, a connector conduit.

12. The syringe and connector assembly of claims 10 or 11, wherein the flow controller directs the medical fluid to flow between the plurality of longitudinal channels between the plurality of longitudinal ribs.

13. The syringe and connector assembly of claim 12, wherein the plurality of longitudinal ribs are configured to enhance surface adhesion of the medical fluid to the inner surface of the frustoconical distal end and along the inner surface of the cylindrical sidewall of the syringe.

14. The syringe and connector assembly of claims 10 or 11, wherein the flow controller is connected to the inner surface of the central bore by one or more spokes.

15. A syringe and connector assembly as described in claims 10 or 11, wherein the flow controller includes a plurality of flow control ribs having equal or unequal angular spacings around the longitudinal axis of the flow controller, wherein the plurality of flow control ribs are on a radially outer surface of the flow controller.

16. A method for reducing the amount of bubbles formed in a medical fluid during a syringe filling process, the method comprising: causing the medical fluid to flow through a flow controller disposed within a central aperture of a mouth of the syringe; diverting, by the flow controller, the medical fluid in a radially outward direction toward an angled portion of an inner surface of the frustoconical distal end of the syringe; causing the medical fluid to flow downwardly along the inner surface of the frustoconical distal end of the syringe; causing the medical fluid to flow downwardly along an interior surface of a cylindrical sidewall of the syringe, wherein the sidewall extends between the frustoconical distal and proximal ends; as well as filling the interior volume of the syringe with the medical fluid; and The proximal end refers to the portion of the syringe that is closest to the injector when the syringe is oriented to be connected to the injector, and the distal end refers to the portion of the syringe that is farthest from the injector when the syringe is oriented to be connected to the injector.

17. The method of claim 16, further comprising: A Coanda effect is induced in the medical fluid by the diverting and flowing steps, so that the number of bubbles formed during the syringe filling process is reduced compared to a filling process that does not include the diverting and flowing steps.

18. A method as claimed in claim 16 or 17, wherein the inner surface of the central hole of the nozzle also includes a plurality of longitudinal ribs formed on the inner surface of the nozzle, and wherein diverting the liquid fluid in a radially outward direction through the flow controller includes diverting the liquid fluid in a radially outward direction toward the plurality of longitudinal ribs through the flow controller.

19. The method of claim 18, wherein flowing the liquid fluid down the inner surface of the frustoconical distal end of the syringe further comprises flowing the medical fluid down the plurality of channels between the plurality of longitudinal ribs.

20. The method of claim 18, wherein the plurality of longitudinal ribs are configured to enhance surface adhesion of the medical fluid to the inner surface of the frustoconical distal end and the inner surface of the cylindrical sidewall of the syringe.

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