A magnet and device applicable to the industrialization of magnetic microbead coating for diagnostic reagents

Abstract

The present invention discloses a magnet applicable to the industrialization of magnetic microsphere coating for diagnostic reagents, which includes a first magnetic ring and a second magnetic ring respectively coated on the left and right sides of the same circle. The first magnetic ring and the second magnetic ring each include more than two magnets, and the extension lines of the magnetic force lines of any two of the magnets intersect. The present invention also discloses a device applicable to the industrialization of magnetic microsphere coating for diagnostic reagents, which includes a cylindrical barrel and the magnet applicable to the industrialization of magnetic microsphere coating for diagnostic reagents as described above. The outer circle of the cylindrical barrel coincides with the same circle respectively coated by the two first magnetic rings, and the two first magnetic rings respectively coat both sides of the cylindrical barrel. The magnet applicable to the industrialization of magnetic microsphere coating for diagnostic reagents aims to solve the technical problems in the prior art that the magnet distribution in the production equipment for the industrialization of magnetic microsphere coating for diagnostic reagents is uneven, the magnetic field strength decays too fast and too small, and the time for clarifying the magnetic bead solution is relatively long.

Description

Technical Field

[0001] The present invention belongs to the technical field of magnetic bead adsorption and separation equipment, and particularly relates to a magnet and equipment suitable for the industrialization of magnetic bead coating for diagnostic reagents. Background Art

[0002] The diagnostic reagent industry has developed rapidly in recent years. Through diagnostic reagents, the cause of the disease can be quickly and accurately detected and diagnosed, and multiple indicators can be detected from a single blood sample collection, which is conducive to medical staff formulating targeted treatment plans and administering medications precisely.

[0003] In the process of research and development and industrialization of diagnostic reagents, magnetic bead coating and separation is the core process. The demand for diagnostic reagents has shown an explosive growth, and the operations of traditional manual laboratories can no longer meet the production needs.

[0004] Such as Figure 1-2 As described, in the existing equipment for large-scale (30L) production, including a cylindrical barrel 01, a stirring device 04 arranged inside the cylindrical barrel 01, and a set of traditional magnetic rings 03 covering the outside of the cylindrical barrel 01, raw materials 02 are arranged inside the cylindrical barrel 01. Its magnet still uses the magnet structure and distribution arrangement structure of the original laboratory and small-scale production. For the above structure, in laboratory and small-scale (test tubes and reagent bottles) production, the magnet and magnetic field distribution are a bit fuzzy and chaotic, and the influence on the results is not obvious, and the adsorption and separation process can be completed in a short time.

[0005] However, in the process of large-scale production, the problem of magnetic field distribution becomes prominent. After testing, using the structure in the prior art, the magnetic field distribution inside the cylindrical barrel 01 is very uneven, and the magnetic field intensity decays too fast and too small in the center of the cylindrical barrel 01. It takes about 20 - 30 minutes to clarify the magnetic bead solution, which severely limits the efficiency of large-scale production. Summary of the Invention

[0006] (I) Technical Problems to be Solved

[0007] Based on this, the present invention provides a magnet suitable for the industrialization of magnetic bead coating for diagnostic reagents. The magnet suitable for the industrialization of magnetic bead coating for diagnostic reagents aims to solve the technical problems of uneven magnet distribution, too fast and too small decay of magnetic field intensity, and long time for clarifying the magnetic bead solution in the production equipment for the industrialization of magnetic bead coating for diagnostic reagents in the prior art.

[0008] (II) Technical Solutions

[0009] To solve the above technical problems, the present invention provides a magnet suitable for the industrialization of magnetic bead coating for diagnostic reagents, including a first magnetic ring and a second magnetic ring respectively covering the left and right sides of the same circle. The first magnetic ring and the second magnetic ring each include more than two magnets, and the extension lines of the magnetic force lines of any two of the magnets intersect.

[0010] Preferably, set the same circle covering the first magnetic ring and the second magnetic ring as the installation reference circle; set the horizontal line passing through the center of the installation reference circle as L1, and the magnets in the first magnetic ring and the magnets in the second magnetic ring are symmetrically arranged along L1.

[0011] Preferably, the magnetization directions of the magnets in the first magnetic ring and the magnetization directions of the magnets in the second magnetic ring are symmetric along L1.

[0012] Preferably, set the vertical line passing through the center of the installation reference circle as L2, and the magnets in the first magnetic ring and the magnets in the second magnetic ring are symmetrically arranged along L2.

[0013] Preferably, the magnetization directions of the magnets in the first magnetic ring and the magnetization directions of the magnets in the second magnetic ring are symmetric along L2.

[0014] Preferably, the first magnetic ring and the second magnetic ring are symmetric structures with respect to each other. The first magnetic ring includes: a middle magnet disposed on L1, and two sets of side magnets symmetrically arranged along L1. Each set of side magnets includes an end magnet spaced from the middle magnet and a plurality of intermediate magnets spaced between the middle magnet and the end magnet;

[0015] The magnetization direction of the middle magnet is along its own radial direction and away from the installation reference circle, the magnetization direction of the end magnet is along its own radial direction and towards the installation reference circle, and the magnetization directions of the plurality of intermediate magnets are directions gradually transitioning from the magnetization direction of the middle magnet to the magnetization direction of the end magnet in sequence;

[0016] The magnetization directions of the two end magnets in the two sets of side magnets are symmetric along L1; the magnetization directions of the plurality of intermediate magnets in the two sets of side magnets are symmetric along L1.

[0017] Preferably, the number of the intermediate magnets is 3.

[0018] Preferably, the first magnetic ring is integrally in the shape of an arc plate, and the degree of the central angle corresponding to the first magnetic ring is 120 - 140°.

[0019] Preferably, the first magnetic ring further includes an arc-shaped installation portion, and a receiving cavity is provided in the arc-shaped installation portion. The middle magnet, the end magnet and the intermediate magnets are all received and fixed in the receiving cavity.

[0020] The present invention also discloses a device applicable to the industrialization of magnetic microbead coating for diagnostic reagents, including a cylindrical barrel. Among them, the device applicable to the industrialization of magnetic microbead coating for diagnostic reagents further includes the magnet applicable to the industrialization of magnetic microbead coating for diagnostic reagents as described above. The outer circle of the cylindrical barrel coincides with the same circle respectively covered by the two first magnetic rings, and the two first magnetic rings respectively cover both sides of the cylindrical barrel.

[0021] (III) Beneficial effects

[0022] Compared with the prior art, the beneficial effects of the magnet applicable to the industrialization of magnetic microbead coating for diagnostic reagents of the present invention mainly include:

[0023] The present invention discloses a magnet applicable to the industrialization of magnetic microbead coating for diagnostic reagents, and further optimizes the magnetic field arrangement mode. Through this structure, the uniformity of the magnetic field distribution is significantly improved, the magnetic field superposition effect is enhanced, and when it is applied to the device for the industrialization of magnetic microbead coating for diagnostic reagents, the adsorption clarification time of magnetic microbeads is shortened from 25 - 30 minutes to 8 - 12 minutes, which is beneficial to the large-scale industrial production of diagnostic reagents. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] The features and advantages of the present invention will be more clearly understood by referring to the accompanying drawings. The drawings are schematic and should not be construed as any limitation to the present invention. In the drawings:

[0025] Figure 1 is a schematic structural diagram of the production equipment for the industrialization of magnetic microbead coating for diagnostic reagents mentioned in the background art of the present invention;

[0026] Figure 2 is Figure 1 the top view of;

[0027] Figure 3 is a schematic structural diagram of the magnet applicable to the industrialization of magnetic microbead coating for diagnostic reagents in the embodiment of the present invention;

[0028] Figure 4 is a schematic diagram of the magnetization direction of the magnet applicable to the industrialization of magnetic microbead coating for diagnostic reagents in the embodiment of the present invention.

[0029] Description of reference numerals:

[0030] 01. Cylindrical barrel, 02. Raw material, 03. Traditional magnetic ring, 04. Stirring device, 1. First magnetic ring, 2. Installation reference circle, 3. Second magnetic ring, 11. Median magnet, 12. End magnet, 13. Intermediate magnet, 14. Arc-shaped installation part, 141. Receiving cavity. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0031] To make the above objects, features, and advantages of the present invention more apparent and understandable, the following provides a detailed description of the specific embodiments of the present invention with reference to the accompanying drawings. Many specific details are set forth in the following description to facilitate a full understanding of the present invention. However, the present invention can be implemented in many other ways different from those described herein, and those skilled in the art can make similar improvements without departing from the connotation of the present invention. Therefore, the present invention is not limited by the specific embodiments disclosed below.

[0032] In the description of the present invention, it should be noted that unless otherwise clearly specified and defined, the terms "connected" and "coupled" should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection, it can be directly connected, or indirectly connected through an intermediate medium, it can be the communication inside two components, or a "transmission connection", that is, a power connection is made through various suitable ways such as belt drive, gear drive, or sprocket drive. For those of ordinary skill in the art, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0033] Refer to the attached Figure 3-4 , a magnet applicable to the industrialization of magnetic microbead coating for diagnostic reagents, comprising a first magnetic ring 1 and a second magnetic ring 3 respectively covering the left and right sides of the same circle. The first magnetic ring 1 and the second magnetic ring 3 each include more than two magnets, and the extension lines of the magnetic force lines of any two magnets intersect.

[0034] In this embodiment, two magnetic rings, namely the first magnetic ring 1 and the second magnetic ring 3, are used to enclose the barrel 01 in an openable and closable manner. Each magnetic ring includes more than two magnets. With this arrangement, it not only meets the requirement of the movement of the magnets but also ensures an effective contact area of sufficient magnets surrounding the barrel 01. The extension lines of the magnetic force lines of any two magnets intersect, and this structure is conducive to forming a uniform and continuous magnetic field distribution inside the barrel. The internal magnetic field distribution of the entire barrel is continuous and substantially uniform, shortening the time for clarifying the magnetic bead solution.

[0035] It should be noted that according to requirements, in addition to selecting the scheme of setting two magnetic rings, three, four, or other numbers of multiple magnetic rings can also be set to obtain the effect of a uniform and continuous magnetic field distribution.

[0036] According to a preferred embodiment of the present invention, the same circle covering the first magnetic ring 1 and the second magnetic ring 3 is set as the installation reference circle 2; the horizontal line passing through the center of the installation reference circle 2 is set as L1, and the magnets in the first magnetic ring 1 and the magnets in the second magnetic ring 3 are symmetrically arranged along L1. The magnetization directions of the magnets in the first magnetic ring 1 and the magnetization directions of the magnets in the second magnetic ring 3 are symmetric along L1. The vertical line passing through the center of the installation reference circle 2 is set as L2, and the magnets in the first magnetic ring 1 and the magnets in the second magnetic ring 3 are symmetrically arranged along L2. The magnetization directions of the magnets in the first magnetic ring 1 and the magnetization directions of the magnets in the second magnetic ring 3 are symmetric along L2. In this embodiment, through the above structure, it is beneficial to further improve the continuity and uniformity of the magnetic field distribution.

[0037] According to a preferred embodiment of the present invention, the first magnetic ring 1 and the second magnetic ring 3 are symmetrical structures with respect to each other. The first magnetic ring 1 includes: a middle magnet 11 disposed on L1, and two sets of side magnets groups symmetrically arranged along L1. Each side magnets group includes an end magnet 12 spaced from the middle magnet 11, and a plurality of intermediate magnets 13 spaced between the middle magnet 11 and the end magnet 12; the magnetization direction of the middle magnet 11 is along its own radial direction and away from the installation reference circle 2, the magnetization direction of the end magnet 12 is along its own radial direction and towards the installation reference circle 2, and the magnetization directions of the plurality of intermediate magnets 13 are directions gradually transitioning from the magnetization direction of the middle magnet 11 to the magnetization direction of the end magnet 12 in sequence. The magnetization direction of the middle magnet 11 is along its own radial direction and away from the installation reference circle 2, the magnetization direction of the end magnet 12 is along its own radial direction and towards the installation reference circle 2, and the magnetization directions of the plurality of intermediate magnets 13 are directions gradually transitioning from the magnetization direction of the middle magnet 11 to the magnetization direction of the end magnet 12 in sequence; the magnetization directions of the two end magnets 12 in the two sets of side magnets groups are symmetric along L1; the magnetization directions of the plurality of intermediate magnets 13 in the two sets of side magnets groups are symmetric along L1.

[0038] According to a preferred embodiment of the present invention, the number of the intermediate magnets 13 is 3. In this embodiment, by the combined action of the intermediate magnets 13, the middle magnet 11 and the end magnet 12, the extension and superposition of the magnetic field distribution are realized, which is beneficial to further strengthening the magnetic field. During specific implementation, the specific number can be reasonably adjusted according to the size and thickness of the magnet.

[0039] According to a preferred embodiment of the present invention, the first magnetic ring 1 is integrally in the shape of an arc plate, and the degree of the central angle corresponding to the first magnetic ring 1 is 120 - 140°.

[0040] More specifically, the central angle corresponding to the first magnetic ring 1 is 130°. In this embodiment, the first magnetic ring 1 is integrally in the shape of an arc plate, and the second magnetic ring 3 is integrally in the shape of an arc plate. This structure facilitates the first magnetic ring 1 and the second magnetic ring 3 to fit with the cylindrical barrel 01 respectively, ensuring effective contact between the magnetic ring and the cylindrical barrel 01. Specifically in implementation, the size of the central angle of the magnetic ring (the first magnetic ring 1 and the second magnetic ring 3) also needs to consider the requirement of the magnetic ring to be movable, and ensure the best effective contact area of the magnet surrounding the cylindrical barrel 01.

[0041] According to a preferred embodiment of the present invention, the first magnetic ring 1 further includes an arc-shaped mounting portion 14, and a receiving cavity 141 is provided in the arc-shaped mounting portion 14. The median magnet 11, the end magnet 12 and the intermediate magnet 13 are all received and fixed in the receiving cavity 141. With the above structure, it is beneficial to the receiving and fixing of the magnet.

[0042] The present invention also discloses a device applicable to the industrialization of diagnostic reagent magnetic microsphere coating, including a cylindrical barrel 01. Among them, the device applicable to the industrialization of diagnostic reagent magnetic microsphere coating further includes a magnet applicable to the industrialization of diagnostic reagent magnetic microsphere coating as described above. The outer circle of the cylindrical barrel 01 coincides with the same circle respectively covered by two first magnetic rings 1, and the two first magnetic rings 1 respectively cover both sides of the cylindrical barrel 01.

[0043] The structure of the magnet applicable to the industrialization of diagnostic reagent magnetic microsphere coating in the device applicable to the industrialization of diagnostic reagent magnetic microsphere coating is different from the structure in the appendix Figure 1 The other structures of the device applicable to the industrialization of diagnostic reagent magnetic microsphere coating refer to the structure in the appendix Figure 1 in the appendix.

[0044] More specifically, the magnets (the median magnet 11, the end magnet 12 and the intermediate magnet 13) in this embodiment are all made of N50H magnets with a temperature resistance of 120 °C, and the thickness of each magnet is 20 mm.

[0045] After using the above structure, the device is uniformly mixed and stirred under the action of low shear force, with a short adsorption time, a large magnetic field strength, a long radiation distance and no attenuation or very little attenuation, and the magnetic field distribution is uniformized. After adopting this structure, the adsorption clarification time is shortened to 8 - 12 minutes, significantly shortening the adsorption clarification time and greatly improving the production efficiency.

[0046] Compared with the prior art, the present invention discloses a magnet applicable to the industrialization of diagnostic reagent magnetic microsphere coating, and further optimizes the magnetic field arrangement mode. Through this structure, the uniformity of the magnetic field distribution can be significantly improved, the magnetic field superposition effect is enhanced, and when it is applied to the device for the industrialization of diagnostic reagent magnetic microsphere coating, the adsorption clarification time of the magnetic microspheres is shortened from 25 - 30 minutes to 8 - 12 minutes, which is beneficial to the large-scale industrial production of diagnostic reagents.

[0047] While embodiments of the present invention have been described in conjunction with the accompanying drawings, those skilled in the art can make various modifications and variations without departing from the spirit and scope of the present invention, and such modifications and variations fall within the scope defined by the appended claims.

Claims

1. A magnet applicable to the industrialization of magnetic microbead coating for diagnostic reagents, characterized in that, It comprises a first magnetic ring (1) and a second magnetic ring (3) which respectively cover the left and right sides of the same circle, wherein the first magnetic ring (1) and the second magnetic ring (3) each comprise more than two magnets, and the extension lines of the magnetic force lines of any two of the magnets intersect; The same circle covered by the first magnetic ring (1) and the second magnetic ring (3) is set as a mounting reference circle (2); and a horizontal line passing through the center of the mounting reference circle (2) is set as L1; The first magnetic ring (1) and the second magnetic ring (3) are symmetrical structures. The first magnetic ring (1) comprises: a middle magnet (11) arranged on the L1, two groups of side magnet groups symmetrically arranged along the L1, the side magnet groups comprising end magnets (12) arranged at intervals from the middle magnet (11), and a plurality of intermediate magnets (13) arranged at intervals between the middle magnet (11) and the end magnets (12); The magnetizing direction of the middle magnet (11) is along its own radial direction and away from the installation reference circle (2), the magnetizing direction of the end magnet (12) is along its own radial direction and pointing to the installation reference circle (2), and the magnetizing direction of the plurality of intermediate magnets (13) is a direction that gradually transitions from the magnetizing direction of the middle magnet (11) to the magnetizing direction of the end magnets (12); A vertical line passing through the center of the installation reference circle (2) is set as L2, and the magnets in the first magnetic ring (1) and the magnets in the second magnetic ring (3) are symmetrically arranged along L2; the magnetizing directions of the magnets in the first magnetic ring (1) and the magnetizing directions of the magnets in the second magnetic ring (3) are symmetrical along L2; the magnetizing directions of the two end magnets (12) in the two groups of edge magnet groups are symmetrical along L1; and the magnetizing directions of the plurality of intermediate magnets (13) in the two groups of edge magnet groups are symmetrical along L1.

2. The magnet applicable to the industrialization of the magnetic microbead coating for diagnostic reagents according to claim 1, wherein The magnets in the first magnetic ring (1) and the magnets in the second magnetic ring (3) are symmetrically arranged along L1.

3. The magnet applicable to the industrialization of magnetic microbead coating for diagnostic reagents according to claim 2, characterized in that, The magnetizing direction of the magnets in the first magnetic ring (1) and the magnetizing direction of the magnets in the second magnetic ring (3) are symmetrical along L1.

4. The magnet applicable to the industrialization of the coating of magnetic microspheres for diagnostic reagents according to claim 3, characterized in that, The number of the intermediate magnets (13) is 3.

5. The magnet applicable to the industrialization of magnetic microbead coating for diagnostic reagents according to claim 4, characterized in that, The first magnetic ring (1) is in the shape of an arc plate as a whole, and the degree of the central angle corresponding to the first magnetic ring (1) is 120-140°.

6. The magnet applicable to the industrialization of magnetic microbead coating for diagnostic reagents according to claim 5, characterized in that, The first magnetic ring (1) further comprises an arc-shaped mounting portion (14), wherein a receiving cavity (141) is provided in the arc-shaped mounting portion (14), and the middle magnet (11), the end magnet (12) and the intermediate magnet (13) are all received and fixed in the receiving cavity (141).

7. An apparatus applicable to the industrialization of magnetic microbead coating for diagnostic reagents, comprising a round barrel (01), characterized in that, The equipment suitable for the industrialization of magnetic microbead coating of diagnostic reagents also includes a magnet suitable for the industrialization of magnetic microbead coating of diagnostic reagents as described in any one of claims 1 to 6, the outer circle of the barrel (01) coincides with the same circle respectively covered by the two first magnetic rings (1), and the two first magnetic rings (1) respectively cover two sides of the barrel (01).

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