Pickering emulsion, cleaning product and preparation method thereof

Abstract

The present invention discloses a Pickering emulsion, which comprises a thickener, an oil phase and an aqueous phase, and forms a stable Pickering emulsion by the selection of the thickener and the oil. Also disclosed are a cleaning product containing the same and a preparation method thereof. The present invention uses a three-dimensional structure formed by compounding a polymer component in a specific proportion with solid particles as the thickener. Tiny emulsified particles are distributed throughout the polymer thickener network, and at the same time, small solid particles are distributed at the interface to stabilize the emulsified particles and prevent aggregation, solving the problem of stratification or demulsification caused by adding oil to a cleaning product without an emulsifier.

Description

Technical Field

[0001] The present invention relates to the field of cosmetics, and particularly to a Pickering emulsion for cleaning products and a preparation method thereof. Background Art

[0002] Emulsifiers are additives widely used in various fields such as food, medicine, biology, and cosmetics. They are used to form stable emulsion liquids from two or more immiscible components. The principle is to reduce the interfacial tension of each component during the emulsification process and form a stable structure on the surface of the emulsion droplets to prevent the aggregation of emulsifying particles.

[0003] Common emulsifiers in the cosmetics industry all have their own disadvantages. For example, small molecule emulsifiers (also denoted as surfactants) have certain irritation, and there is a certain risk of environmental pollution in the production process. Macromolecular emulsifiers have weak emulsifying performance, high dosage, and instability.

[0004] Pickering emulsification technology is a new emulsification method that uses solid particles instead of traditional surfactants to maintain the stability of emulsions, with many advantages such as strong stability, low dosage, low cost, and high safety. Li Haiming, Yang Sheng, Wei Hewen, etc. Research progress of food-grade Pickering emulsions [J]. Food Science, 2015, (19). 265 - 270. doi:10.7506 / spkx1002 - 6630 - 201519048.

[0005] Most existing facial cleansing products on the market contain soap bases or a large amount of surfactants, and use their degreasing ability to clean the skin, but there are risks such as excessive degreasing, affecting the skin microecological balance, and damaging the skin barrier.

[0006] In the prior art, Pickering emulsions often use surfactants to achieve the effect of stabilizing emulsions. In addition, titanium dioxide is used as solid particles, and such products have certain irritation to the skin. Therefore, it is necessary to design a new Pickering emulsion to solve the problems of stability, safety, and cleaning performance. Summary of the Invention

[0007] Aiming at the problems existing in the prior art, the present invention provides a cleaning product in the form of a Pickering emulsion, which uses a three-dimensional structure of a polymer component compounded with solid particles as a thickener. This cleaning product does not contain surfactants, reducing the irritation to the skin. Through the reasonable compounding of the thickener and oil, the cleaning effect under a low oil addition is ensured, and the problem of oil residue affecting the skin feel caused by too high oil content is avoided. In addition, tiny emulsified particles are distributed throughout the grid formed by the polymer thickener (the oil is suspended in the system in the form of small droplets), and small solid particles are distributed at the interface to stabilize the emulsified particles and prevent aggregation, thereby achieving the effect of stabilizing the emulsion.

[0008] The technical solution of the present invention is as follows:

[0009] The present invention also provides a Pickering emulsion, mainly comprising: 0.1-5% thickener, 0.1-10% oil phase and 80-95% water phase. A stable Pickering emulsion is formed by compounding the thickener with the oil, and no emulsifier is contained.

[0010] By compounding a specific content of the thickener with the oil, the small droplets formed by the oil are dispersed in the three-dimensional network formed by the polymer thickener, thereby forming a stable Pickering emulsion. Without the use of an emulsifier, the product is milder and less irritating compared with the prior art. In addition, the system contains a certain amount of oil, and by means of the principle of similar solubility, the effect of gently cleaning the skin is achieved, and the damage to the normal skin flora is small and other characteristics.

[0011] In some embodiments, the addition amount of the thickener is 1%-3%. The compounding of a specific content of the thickener further improves the emulsion stability and ensures a high cleaning effect.

[0012] In some embodiments, the thickener is selected from one or a combination of carbomer and / or its salts, PEG-240 / HDI copolymer bis-decyltetradecyl polyether-20 ether, sodium polyacrylate grafted starch, corn (ZEAMAYS) starch, tapioca starch, hydrolyzed corn starch, kaolin. These thickeners can form a stable Pickering emulsion and help form emulsifying particles and suspend them in the system without adding an emulsifier.

[0013] In some embodiments, the thickener is PEG-240 / HDI copolymer bis-decyltetradecyl polyether-20 ether, carbomer and / or its salts, and sodium polyacrylate grafted starch.

[0014] In some embodiments, the mass ratio of PEG-240 / HDI copolymer bis-decyltetradecyl polyether-20 ether, carbomer and / or its salts, and sodium polyacrylate grafted starch is 1-3:1-3:1-3, preferably 1-3:2:1. The compounding of this kind of thickener can achieve the effect of stabilizing the emulsion and preventing stratification.

[0015] In some embodiments, the carbomer salt is carbomer sodium.

[0016] In some embodiments, the solid particles are sodium polyacrylate grafted starch and / or PEG-240 / HDI copolymer bis-decyltetradecyl polyethylene glycol-20 ether. That is, the components of the thickener in the present invention act as both a thickener and solid particles. The solid particles used in Pickering emulsions in the prior art are usually metal oxides such as titanium dioxide, which can cause friction during contact with the skin and are more likely to clog pores. However, the sodium polyacrylate grafted starch and / or PEG-240 / HDI copolymer bis-decyltetradecyl polyethylene glycol-20 ether in the thickener of this application act as solid particles, distributing at the interface to stabilize the emulsified particles and prevent aggregation, thereby achieving the effect of stabilizing the emulsion.

[0017] In some embodiments, the oil addition amount is 3%-5%. The compounding of specific amounts of oil further improves the emulsion stability and ensures a high cleaning effect.

[0018] In some embodiments, the oil is selected from one or more of synthetic oils, alkanes, and vegetable oils.

[0019] In some embodiments, the oil is selected from one or more of synthetic oils and vegetable oils.

[0020] In some embodiments, the synthetic oil is selected from one or a combination of ethylhexyl palmitate, cetyl alcohol ethylhexanoate, triglyceride caprylate / caprate, synthetic squalane, and triglyceride (ethylhexanoic acid).

[0021] In some embodiments, the alkane is selected from one or a combination of isododecane, isocetane, hydrogenated polydecene, and hydrogenated polyisobutene, and the vegetable oil is selected from one or a combination of jojoba (SIMMONDSIA CHINENSIS) seed oil, avocado (PERSEA GRATISSIMA) oil, limnanthes alba (LIMNANTHES ALBA) seed oil, and sunflower (HELIANTHUS ANNUUS) seed oil.

[0022] In some embodiments, the oil is one or two of ethylhexyl palmitate and jojoba (SIMMONDSIA CHINENSIS) seed oil. The oil is compounded with the thickener to stabilize the emulsion and improve the cleaning power at the same time.

[0023] In some embodiments, the aqueous phase includes a humectant, wherein the humectant is selected from one or a combination of glycerol, glycerol polyether-26, diglycerol, dipropylene glycol, propylene glycol, methyl propylene glycol, butylene glycol, polyethylene glycol-6, polyethylene glycol-8, and sorbitol, preferably a combination of one or more of glycerol and butylene glycol.

[0024] In some embodiments, the aqueous phase further comprises a moisturizing factor selected from one or a combination of betaine, trehalose, urea, D-panthenol, sodium hyaluronate, chitooligosaccharide, preferably sodium hyaluronate.

[0025] In some embodiments, the addition amount of the humectant is 1-60%, and the addition amount of the moisturizing factor is 0.001-10%. The humectant and the moisturizing factor are the most added active substances in cosmetics, which mainly affect the skin feel and can be formulated according to the sensory evaluation of consumers.

[0026] In some embodiments, the Pickering emulsion further comprises 0.001-1% of an anti-allergic and anti-inflammatory agent selected from one or a combination of dipotassium glycyrrhizinate and allantoin.

[0027] In some embodiments, the Pickering emulsion further comprises 0.001-20% of an auxiliary component selected from at least one of a bacteriostatic agent, a chelating agent, a skin conditioner, a fragrance and a pigment, and a pH regulator.

[0028] In some embodiments, the bacteriostatic agent comprises one or a combination of p-hydroxyacetophenone, methylparaben, propylparaben, phenoxyethanol, sodium benzoate, potassium sorbate, and DMDM hydantoin.

[0029] In some embodiments, the chelating agent comprises one or a combination of disodium EDTA and tetrasodium EDTA.

[0030] In some embodiments, the skin conditioner comprises one or a combination of sodium hyaluronate, betaine, allantoin, asiaticoside, dipotassium glycyrrhizinate, ectoin, tea extract, and sapindus mukorossi extract.

[0031] In some embodiments, the fragrance comprises (daily use) fragrance or other essential oils.

[0032] In some embodiments, the pigment comprises one or a combination of acid red, acid blue, purple pigment, black pigment, and brown pigment.

[0033] In some embodiments, the pH regulator comprises one or a combination of citric acid, sodium citrate, potassium hydroxide, sodium hydroxide, triethanolamine, and arginine.

[0034] On the other hand, the present invention also provides a method for preparing the Pickering emulsion according to any one of the above, which is characterized by comprising the following steps:

[0035] (1) Add the aqueous phase and the thickener into a reaction vessel and stir evenly;

[0036] (2) Add the oil phase and homogenize and emulsify evenly;

[0037] (3) Add a moisturizing factor, an anti-allergic and anti-inflammatory agent, and auxiliary components, and stir evenly.

[0038] On the other hand, the present invention also provides a cleaning product made of the Pickering emulsion described in any one of the above.

[0039] In some embodiments, its dosage form is an emulsion or a cream.

[0040] On the other hand, the present invention also provides a facial cleanser made of the Pickering emulsion described in any one of the above.

[0041] Compared with the prior art, the beneficial effects of the present invention are as follows:

[0042] First, the cleaning product of the present invention does not contain surfactants and is non-irritating to the skin.

[0043] Second, the present invention uses a three-dimensional structure of a polymer component compounded with solid particles as a thickener. Tiny emulsion particles are distributed throughout the grid formed by the polymer thickener, and small solid particles are distributed at the interface to stabilize the emulsion particles and prevent aggregation, solving the problem of stratification or demulsification caused by adding oil to a cleaning product without an emulsifier.

[0044] Third, the present invention is compounded with a thickener in a specific proportion, which not only ensures the addition of a specific content of oil in the system. By virtue of the principle of similar solubility, it can achieve the effect of gently cleaning the skin and cause less damage to the normal skin flora; at the same time, due to the fat-stabilizing effect of the thickener, it ensures the cleaning effect with a low oil addition and avoids the influence of excessive oil content on the skin feel caused by oil residue.

[0045] Of course, any product implementing the present invention does not necessarily need to achieve all the above-mentioned advantages simultaneously. BRIEF DESCRIPTION OF THE DRAWINGS

[0046] Figure 1 is a schematic diagram of the result of Verification Example 2 of the present invention;

[0047] Figure 2 is a schematic diagram of the water content test result of Verification Example 3 of the present invention;

[0048] Figure 3 is a schematic diagram of the oil content test result of Verification Example 3 of the present invention;

[0049] Figure 4 is a schematic diagram of the skin pH test result of Verification Example 3 of the present invention;

[0050] Figure 5 is a schematic diagram of the water loss test result of Verification Example 4 of the present invention;

[0051] Figure 6.1Schematic diagram of the results of repeated (acute) skin irritation test of the balanced facial cleanser of the present invention;

[0052] Figure 6.2 Schematic diagram of the results of the acute eye irritation test of the balanced facial cleanser of the present invention. Detailed implementation manners

[0053] In this article, a range represented by "from one value to another value" is a summary representation method to avoid listing all the values in this range one by one in the specification. Therefore, the description of a specific numerical range covers any value within this numerical range and the smaller numerical range defined by any value within this numerical range, as if the arbitrary value and the smaller numerical range are clearly written in the specification.

[0054] In this article, all percentages are mass percentages.

[0055] The present invention will be further described below in conjunction with specific embodiments. It should be understood that these embodiments are only used to illustrate the present invention and are not used to limit the protection scope of the present invention. Improvements and adjustments made by those skilled in the art according to the present invention in actual applications still fall within the protection scope of the present invention.

[0056] Example 1 Preparation of balanced facial cleanser

[0057] Take 20 parts of glycerol, 30 parts of butanediol, 0.4 part of sodium carbomer, 0.05 part of sodium hyaluronate, 0.6 part of PEG-240 / HDI copolymer bis-decyldodeceth-20 ether, 0.2 part of sodium polyacrylate grafted starch, 0.4 part of hydroxyacetophenone, and 0.4 part of hexylene glycol and put them into a beaker. After mixing, add 43.45 parts of water and start heating and stirring;

[0058] Take 3.5 parts of ethylhexyl palmitate and 1 part of jojoba (SIMMONDSIA CHINENSIS) seed oil and add them to the beaker together, homogenize and emulsify evenly, and set aside.

[0059] Example 2 Preparation of balanced facial cleanser

[0060] Take 20 parts of glycerol, 30 parts of butanediol, 0.05 part of sodium hyaluronate, 0.6 part of PEG-240 / HDI copolymer bis-decyldodeceth-20 ether, 0.2 part of sodium polyacrylate grafted starch, 0.4 part of hydroxyacetophenone, and 0.4 part of hexylene glycol and put them into a beaker. After mixing, add 43.85 parts of water and start heating and stirring;

[0061] Take 3.5 parts of ethylhexyl palmitate and 1 part of jojoba (SIMMONDSIA CHINENSIS) seed oil and add them to the beaker together, homogenize and emulsify evenly, and set aside.

[0062] Preparation of Balanced Cleansing Cream in Example 3

[0063] Take 20 parts of glycerol, 30 parts of butanediol, 0.4 part of sodium carbomer, 0.05 part of sodium hyaluronate, 0.2 part of sodium polyacrylate grafted starch, 0.4 part of p-hydroxyacetophenone, and 0.4 part of hexylene glycol and put them into a beaker. After mixing, add 44.05 parts of water and start heating and stirring;

[0064] Take 3.5 parts of ethylhexyl palmitate and 1 part of jojoba (SIMMONDSIA CHINENSIS) seed oil and add them to the beaker together. Homogenize and emulsify evenly for standby.

[0065] Preparation of Balanced Cleansing Cream in Example 4

[0066] Take 20 parts of glycerol, 30 parts of butanediol, 0.4 part of sodium carbomer, 0.05 part of sodium hyaluronate, 0.6 part of PEG-240 / HDI copolymer bis-decyltetradecyl polyethylene glycol-20 ether, 0.4 part of p-hydroxyacetophenone, and 0.4 part of hexylene glycol and put them into a beaker. After mixing, add 43.65 parts of water and start heating and stirring;

[0067] Take 3.5 parts of ethylhexyl palmitate and 1 part of jojoba (SIMMONDSIA CHINENSIS) seed oil and add them to the beaker together. Homogenize and emulsify evenly for standby.

[0068] Preparation of Balanced Cleansing Cream in Example 5

[0069] Take 20 parts of glycerol, 30 parts of butanediol, 0.8 part of sodium carbomer, 0.05 part of sodium hyaluronate, 1 part of PEG-240 / HDI copolymer bis-decyltetradecyl polyethylene glycol-20 ether, 0.5 part of sodium polyacrylate grafted starch, 0.4 part of p-hydroxyacetophenone, and 0.4 part of hexylene glycol and put them into a beaker. After mixing, add 42.35 parts of water and start heating and stirring;

[0070] Take 3.5 parts of ethylhexyl palmitate and 1 part of jojoba (SIMMONDSIA CHINENSIS) seed oil and add them to the beaker together. Homogenize and emulsify evenly for standby.

[0071] Examples 6, 8, 9

[0072] Prepare the cleansing cream according to any one of the methods in Examples 1, 2, 3, 4, and 5. The total mass fraction of the raw materials is 100. Among them, the addition amounts of glycerol, butanediol, sodium hyaluronate, ethylhexyl palmitate, and jojoba seed oil are the same as those in the above examples. The addition amounts of sodium carbomer, PEG-240 / HDI copolymer bis-decyltetradecyl polyethylene glycol-20 ether, and sodium polyacrylate grafted starch are shown in Table 1, and the rest is water. The cleansing creams of Examples 6, 8, and 9 are obtained respectively.

[0073] Example 7

[0074] Prepare a facial cleanser paste according to any one of the methods of Examples 1, 2, 3, 4, and 5. The total mass fraction of the raw materials is 100. Among them, the addition amounts of glycerin, butanediol, sodium hyaluronate, ethylhexyl palmitate, and jojoba seed oil are the same as those in the above examples. The difference is that in this example, sodium carbomer is replaced with xanthan gum. The addition amounts of xanthan gum, PEG-240 / HDI copolymer bis-decyltetradecyl polyether-20 ether, and sodium polyacrylate grafted starch are shown in Table 1, and the rest is water.

[0075] The differences between Examples 1-9 lie in the selection and content of the thickener, as shown in Table 1 specifically. The unit of the values in Table 1 is mass fraction.

[0076] Table 1

[0077]

[0078] Preparation of the balanced facial cleanser paste of Example 10

[0079] Take 20 parts of glycerin, 30 parts of butanediol, 0.4 part of sodium carbomer, 0.05 part of sodium hyaluronate, 0.6 part of PEG-240 / HDI copolymer bis-decyltetradecyl polyether-20 ether, 0.2 part of sodium polyacrylate grafted starch, 0.4 part of p-hydroxyacetophenone, and 0.4 part of hexylene glycol and put them into a beaker. After mixing, add 47.45 parts of water and start heating and stirring evenly; reserve for later use.

[0080] Take 0.5 part of ethylhexyl palmitate and add it to the beaker, homogenize and emulsify evenly, and reserve for later use.

[0081] Preparation of the balanced facial cleanser paste of Example 11

[0082] Take 20 parts of glycerin, 30 parts of butanediol, 0.4 part of sodium carbomer, 0.05 part of sodium hyaluronate, 0.6 part of PEG-240 / HDI copolymer bis-decyltetradecyl polyether-20 ether, 0.2 part of sodium polyacrylate grafted starch, 0.4 part of p-hydroxyacetophenone, and 0.4 part of hexylene glycol and put them into a beaker. After mixing, add 40.45 parts of water and start heating and stirring;

[0083] Take 6 parts of ethylhexyl palmitate and 1.5 parts of jojoba (SIMMONDSIA CHINENSIS) seed oil and add them to the beaker together, homogenize and emulsify evenly, and reserve for later use.

[0084] Preparation of the balanced facial cleanser paste of Example 12

[0085] Take 20 parts of glycerin, 30 parts of butylene glycol, 0.4 part of sodium carbomer, 0.05 part of sodium hyaluronate, 0.6 part of PEG-240 / HDI copolymer bis-decyltetradeceth-20, 0.2 part of sodium polyacrylate grafted starch, 0.4 part of hydroxyacetophenone, and 0.4 part of hexylene glycol and put them into a beaker. After mixing, add 34.95 parts of water and start heating and stirring.

[0086] Take 10.5 parts of ethylhexyl palmitate and 3 parts of jojoba (SIMMONDSIA CHINENSIS) seed oil, add them together to the beaker, homogenize and emulsify evenly, and set aside.

[0087] Preparation of balanced facial cleanser in Example 13

[0088] Take 20 parts of glycerin, 30 parts of butylene glycol, 0.4 part of sodium carbomer, 0.05 part of sodium hyaluronate, 0.6 part of PEG-240 / HDI copolymer bis-decyltetradeceth-20, 0.2 part of sodium polyacrylate grafted starch, 0.4 part of hydroxyacetophenone, and 0.4 part of hexylene glycol and put them into a beaker. After mixing, add 34.95 parts of water and start heating and stirring.

[0089] Take 8 parts of ethylhexyl palmitate and 2 parts of jojoba (SIMMONDSIA CHINENSIS) seed oil, add them together to the beaker, homogenize and emulsify evenly, and set aside.

[0090] Preparation of balanced facial cleanser in Example 14

[0091] Take 20 parts of glycerin, 30 parts of butylene glycol, 0.4 part of sodium carbomer, 0.05 part of sodium hyaluronate, 0.6 part of PEG-240 / HDI copolymer bis-decyltetradeceth-20, 0.2 part of sodium polyacrylate grafted starch, 0.4 part of hydroxyacetophenone, and 0.4 part of hexylene glycol and put them into a beaker. After mixing, add 34.95 parts of water and start heating and stirring.

[0092] Take 2.4 parts of ethylhexyl palmitate and 0.6 part of jojoba (SIMMONDSIA CHINENSIS) seed oil, add them together to the beaker, homogenize and emulsify evenly, and set aside.

[0093] Preparation of balanced facial cleanser in Example 15

[0094] Take 20 parts of glycerin, 30 parts of butylene glycol, 0.4 part of sodium carbomer, 0.05 part of sodium hyaluronate, 0.6 part of PEG-240 / HDI copolymer bis-decyltetradeceth-20, 0.2 part of sodium polyacrylate grafted starch, 0.4 part of hydroxyacetophenone, and 0.4 part of hexylene glycol and put them into a beaker. After mixing, add 34.95 parts of water and start heating and stirring.

[0095] Take 3.5 parts of synthetic squalane and 1 part of Limnanthes Alba seed oil and add them to a beaker. Homogenize and emulsify evenly for later use.

[0096] The differences between Example 1 and Examples 10 - 15 lie in the selection and content of oils and fats, as shown in Table 2 specifically.

[0097] Table 2 (unit: mass fraction)

[0098]

[0099]

[0100] Verification Example 1 Stability Test

[0101] Examine the product stability under the corresponding temperature oven and normal temperature natural light conditions. After three months at normal temperature, one month at high and low temperatures and under light for the cleaning products prepared in Examples 1 - 15, observe whether there is stratification or other stability problems.

[0102] After centrifuging the cleaning products prepared in Examples 1 - 15 at 2000 rpm for 30 minutes, observe whether there is stratification or other stability problems.

[0103] The results are shown in Table 3 below.

[0104] Table 3 Stability of Examples 1 - 15

[0105]

[0106]

[0107] In Examples 2, 3, 4, 7, and 12, after three months at normal temperature, one month at high and low temperatures and under light, and 30 - minute centrifugation at 2000 rpm, demulsification occurred and there were stability problems.

[0108] Verification Example 2 Cleaning Effect Test

[0109] Conduct cleaning effect tests on Examples 1, 5, 6, 8, 9, 10, 11, 13, 14, and 15 without stability problems.

[0110] Two volunteers applied makeup (lipstick) on their left and right forearms for cleaning tests. Blind tests were conducted using Example 1 and Example 10 respectively to compare the cleaning effects.

[0111] After taking a small amount of the sample and applying and cleaning it once, the results are as Figure 1 shown. It can be found that the cleaning effect of Example 1 (left side) is better than that of Example 10 (right side).

[0112] The makeup removal effects of Synchronous Test Examples 1, 5, 6, 8, 9, 10, 11, 13, 14, and 15 after a limited number of washes were scored on a 10-point scale (10 points indicating no cleaning effect and 0 points indicating completely clean) by 2 testers and 2 test personnel based on the residual color. The results are shown in Table 4.

[0113] Table 4 Cleaning Effect

[0114]

[0115]

[0116] As can be seen from Table 4 above, as the oil content increases, the cleaning situation improves but does not always increase. Excessive oil may cause a decrease in the subjective use feeling; while with the increase of the thickener, it is more difficult for the formulated oil to demulsify, the dissolution performance of makeup in the early stage decreases, and the cleaning efficiency becomes low.

[0117] Verification Example 3 Efficacy Test

[0118] Four volunteers conducted efficacy tests of cleaning products on the left and right half faces. They were blindly tested using a commercially available competitor product (Shiseido Specialist Facial Wash) and Example 1 (also denoted as Balanced Cleansing Cream). Two hours after washing, the skin moisture content, oil content, and pH value were measured and compared with the baseline values before using the products.

[0119] 3.1 Moisture Content

[0120] The test results of the moisture content are as Figure 2 shown. It can be seen from Figure 2 that using the Balanced Cleansing Cream results in a smaller decrease in skin moisture content than the competitor product.

[0121] 3.2 Oil Content

[0122] The test results are as Figure 3 shown. It can be seen from Figure 3 that using the Balanced Cleansing Cream can better control sebum secretion and does not make the skin oilier after washing.

[0123] 3.3 Skin pH

[0124] The test results are as Figure 4 shown. It can be seen from Figure 4 that the Balanced Cleansing Cream has a smaller impact on skin pH than the competitor product.

[0125] Verification Example 4 Transdermal Water Loss Test

[0126] Two volunteers conducted multiple cleaning tests on the left and right forearms. They were blindly tested using a commercially available competitor product (Shiseido Specialist Facial Wash) and Example 1. After 15 washes, the skin TEWL (transdermal water loss) was measured.

[0127] The test results are as Figure 5 shown. From Figure 5 it can be seen that after using the balanced facial cleanser, the upward trend of the skin TEWL value is slower than that of the competing products. And after 15 washes, the TEWL value of the area where the balanced facial cleanser is used is lower than that of the area where the competing product is used, indicating that the balanced facial cleanser causes less damage to the skin barrier than the competing products.

[0128] Verification Example 5 Microecological Influence

[0129] Prepare Example 1 without hydroxyacetophenone and hexylene glycol, and prepare a soap-based facial cleanser without hydroxyacetophenone, hexylene glycol and other bacteriostatic agents (using fatty acids plus potassium hydroxide). The specific preparation method of the soap-based facial cleanser is as follows:

[0130] Take 20 g of glycerol, 30 g of butanediol, and 0.05 g of sodium hyaluronate and put them into a beaker. After mixing, add 13.95 g of water and 6 g of potassium hydroxide, and start heating and stirring;

[0131] Take 5 g of lauric acid, 10 g of myristic acid, and 15 g of stearic acid, heat them up and dissolve them, then add them to the beaker, and stir until saponification is uniform for standby.

[0132] Add the same number of Staphylococcus epidermidis and Staphylococcus aureus to the materials of Example 1 and the soap-based facial cleanser respectively. After incubating for two hours, observe the colony survival rate. The results are shown in Table 5.

[0133] Table 5 Colony Survival Rate

[0134]

[0135] As can be seen from Table 5 above, the soap-based facial cleanser product has an impact on both beneficial bacteria (Staphylococcus epidermidis) and harmful bacteria (Staphylococcus aureus) on the skin surface, and the colony survival rate almost drops to 0; when using the balanced facial cleanser, it basically does not affect the skin microecology and still maintains at one order of magnitude (10 6 ).

[0136] Verification Example 6 Safety Test

[0137] Perform a third-party animal safety test on Example 1 of the present invention and pass it. The specific report is shown in Figure 6.1 and Figure 6.2 .

[0138] 6.1 Multiple (acute) skin irritation test:

[0139] The test method refers to the (Cosmetics Technical Specifications) 2015 edition, CFDA. The experimental animals are guinea pigs (female / male) weighing 250 - 300 g, divided into 3 groups, with 4 in each group. This balanced facial cleanser (i.e., the attached Figure 6.1Gentle Cleansing Paste in - 1) Apply it on both sides of the spine on the back of guinea pigs. The test time for the three groups of guinea pigs was 1 day, 2 days, and 3 days respectively. After applying for 2 hours, rinse it off and observe the irritation reaction at the application site.

[0140] The results are shown in Figure 6.1 , and no irritation reaction was observed in the three groups of guinea pigs.

[0141] 6.2 Acute Eye Irritation Test

[0142] The test method refers to the "Cosmetics Technical Specifications" 2015 edition. The test animals are rabbits (female / male), the experimental temperature is 20 - 24 °C, and the humidity is 60 - 70%.

[0143] The specific test method is as follows:

[0144] Gently pull down the lower eyelid of one eye of the rabbit, and drop (or apply) 0.1 mL (100 mg) of the test substance into the conjunctival sac, and make the upper and lower eyelids close passively for 1 s to prevent the loss of the test substance. The other eye is not treated as a self - control.

[0145] At the 30th second, rinse with a sufficient amount of water flow that is fast but will not cause eye damage to the animal for 30 s, and observe and score the cornea, iris, and conjunctiva.

[0146] The results are shown in Figure 6.2 , and no irritation reaction was observed in the three groups of guinea pigs.

[0147] Conclusion:

[0148] The finished product of this cleaning product has passed the three - month normal - temperature stability test, one high - and - low - temperature and light test, and passed the high - speed centrifugation test. The stabilities of Examples 1, 5, 6, 8, 9, 10, 11, 13, 14, and 15 are all okay.

[0149] Through the animal safety test, there is no irritation risk;

[0150] Compared with commercially available cleaning products, a comparative test was carried out. The cleaning ability is comparable to that of competing products; the water content, oil content, barrier protection, and skin pH change after washing are all better than those of competing products; the impact on skin microecology is also better than that of competing products.

[0151] Under the teaching of the present invention and the above - mentioned embodiments, those skilled in the art can easily foresee that each raw material or its equivalent substitute, each processing method or its equivalent substitute listed or exemplified in the present invention can achieve the present invention, and the upper and lower limit values and interval values of the parameters of each raw material and processing method can also achieve the present invention. Examples are not listed one by one here.

Claims

1. A Pickering emulsion, characterized in that, it comprises: 1 - 5% thickener, 3 - 10% oil phase, 80 - 95% water phase; the thickener is PEG - 240 / HDI copolymer bis - decyltetradeceth - 20 ether, carbomer and / or its salts, and sodium polyacrylate grafted starch.

2. The Pickering emulsion according to claim 1, characterized in that, the addition amount of the thickener is 1% - 3%.

3. The Pickering emulsion according to claim 1, characterized in that, the addition amount of the oil phase is 3% - 5%.

4. The Pickering emulsion according to claim 1, characterized in that, the mass ratio of PEG - 240 / HDI copolymer bis - decyltetradeceth - 20 ether, carbomer and / or its salts, and sodium polyacrylate grafted starch is 1 - 3:1 - 3:1 - 3.

5. The Pickering emulsion according to claim 4, characterized in that, the mass ratio of PEG - 240 / HDI copolymer bis - decyltetradeceth - 20 ether, carbomer and / or its salts, and sodium polyacrylate grafted starch is 1 - 3:2:

1.

6. The Pickering emulsion according to claim 1, characterized in that, the oil phase is a grease, and the grease is selected from one or more of synthetic greases, alkanes, and vegetable greases.

7. The Pickering emulsion according to claim 6, characterized in that, the grease is selected from one or more of synthetic greases and vegetable greases.

8. The Pickering emulsion according to claim 6, characterized in that, the synthetic grease is selected from one or its combination of ethylhexyl palmitate, cetyl ethylhexanoate, triglyceride of caprylic acid / capric acid, synthetic squalane, and tri(ethylhexanoic acid) glyceride; the alkane is selected from one or its combination of isododecane, isocetane, hydrogenated polydecene, and hydrogenated polyisobutene; the vegetable grease is selected from one or its combination of jojoba seed oil, avocado oil, Limnanthes alba seed oil, and sunflower seed oil.

9. The Pickering emulsion according to claim 1, characterized in that, the water phase comprises 1 - 60% humectant, wherein the humectant is selected from one or its combination of glycerol, glycerol polyether - 26, diglycerol, dipropylene glycol, propylene glycol, methyl propylene glycol, butylene glycol, polyethylene glycol - 6, polyethylene glycol - 8, and sorbitol.

10. The Pickering emulsion according to claim 9, characterized in that, the humectant is a combination of one or more of glycerol and butylene glycol.

11. The Pickering emulsion according to claim 9, characterized in that, the water phase further comprises 0.001 - 10% moisturizing factor, and the moisturizing factor is selected from one or its combination of betaine, trehalose, urea, D - panthenol, sodium hyaluronate, and N - acetylglucosamine.

12. The Pickering emulsion according to claim 11, characterized in that, the moisturizing factor is sodium hyaluronate.

13. The Pickering emulsion according to claim 1, characterized in that, the Pickering emulsion further contains 0.001 - 1% anti - allergic and anti - inflammatory agent, and the anti - allergic and anti - inflammatory agent is selected from one or its combination of dipotassium glycyrrhizinate and allantoin.

14. The Pickering emulsion according to claim 1, characterized in that, The Pickering emulsion further comprises 0.001-20% of an auxiliary component, and the auxiliary component is selected from at least one of bacteriostatic agents, chelating agents, skin conditioners, flavors and pigments, and pH regulators.

15. A method for preparing the Pickering emulsion according to any one of claims 1-14, characterized in that it comprises the following steps: (1) adding an aqueous phase and a thickening agent into a reaction vessel and stirring evenly; (2) adding an oil phase and homogenizing and emulsifying evenly; (3) adding a moisturizing agent, a moisturizing factor, an anti-allergic and anti-inflammatory agent, and an auxiliary component and stirring all evenly.

16. A cleaning product, characterized in that it is made of the Pickering emulsion according to any one of claims 1-14 or the Pickering emulsion prepared by the preparation method according to claim 15.

17. The cleaning product according to claim 16, characterized in that its dosage form is emulsion or cream.

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