Liquid sample collection device and detection device

Abstract

The present invention provides a liquid sample collection device, comprising a liquid sample collection bottle and a sampler, wherein the inner wall of the liquid sample collection bottle is provided with a guide rail that tilts and spirals downward from top to bottom, and the lower end of the sampler's stem is provided with a guide groove. After the lower end of the sampler's stem is inserted into the liquid sample collection bottle, the guide groove at the lower end of the stem cooperates with the guide rail on the inner wall of the bottle, guiding the lower end of the sampler's stem to spiral downward within the liquid sample collection bottle, thereby squeezing the sampler's liquid-drawing portion. Compared with the prior art, the present invention has a higher liquid sample extrusion rate, making it easier to meet the minimum amount of liquid sample required for testing, thereby improving the success rate of testing and the accuracy of test results.

Description

Technical Field

[0001] The present invention belongs to the technical field of medical devices, and further belongs to the field of medical testing, and in particular relates to a liquid sample collection device and a detection device. Background Art

[0002] There are a variety of clinical lateral flow immunoassay devices that can be used to detect the presence of analytes in samples, such as hormones, sugars, adulterants, drugs of abuse, etc. Typically, a liquid sample is collected and added to the lateral flow immunoassay device, and then a certain component or components in the liquid sample are detected.

[0003] The liquid sample can be any volume of liquid to be tested, examined or studied. The liquid sample can be derived from any liquid, such as body fluids, such as saliva, blood, urine, or other liquids to be tested, such as water samples from contaminated sources, liquid samples from beverages, etc.

[0004] Liquid samples are usually collected and absorbed using a sampling rod, which has a collecting element formed of an absorbent material such as a pad or sponge, and the collecting element is connected to one end of the plunger. The collecting element allows a sufficient volume of sample liquid to be absorbed from the liquid source, and the presence of the sample liquid in the collecting element causes the interior of the collecting element to swell. The collecting element usually holds the sample until the collecting element is operated to release the sample. During testing, the existing technology usually uses an extrusion method to squeeze the liquid sample out of the collecting element of the sampling rod, and then add it to the detection device (such as a lateral flow immunoassay device) for detection; or in some tests, the squeezed liquid sample needs to be mixed / lysed with a buffer solution and other pretreatments before being added to the detection device for detection.

[0005] In existing operations, a collection bottle is used to collect the liquid sample on the collection element. That is, the collection element end of the sampling stick is inserted into the collection bottle, and the collection element is pressed against the side wall or bottom of the collection bottle body to make the liquid sample flow out into the collection bottle for sample collection. A problem with existing collection bottles and sampling sticks is that the liquid sample on the collection element of the sampling stick cannot be fully squeezed out. That is, after squeezing, a large amount of liquid sample still remains on the collection element, so that only a small amount of liquid sample is used for subsequent testing. This can easily result in insufficient amount of liquid sample for testing, resulting in test failure or inaccurate test results (especially when the liquid sample is saliva. Generally, the amount of saliva that a human or animal can release in a short period of time is very limited, which can easily lead to insufficient amount of liquid sample). In addition, when there is a buffer solution in the collection bottle, the collection element will also absorb and carry away part of the buffer solution or the mixture of the liquid sample and the buffer solution, thereby affecting the accuracy of the test results. Summary of the Invention

[0006] One of the purposes of the present invention is to provide a liquid sample collection bottle for collecting liquid samples from humans or animals in response to the deficiencies in the prior art.

[0007] The above-mentioned object of the present invention is achieved through the following technical solutions:

[0008] A liquid sample collection bottle comprises a bottle body, wherein the bottle body comprises an inner wall and an outer wall, the inner wall comprises a cylindrical portion, wherein the cylindrical portion of the inner wall of the bottle body is provided with a guide rail which is inclined from top to bottom and spirally descends.

[0009] As a further improvement of the present invention, the cross section of the guide rail is rectangular, triangular, trapezoidal or arc-shaped, and the portion with a larger cross section of the guide rail is located on the inner wall of the bottle body.

[0010] As a further improvement of the present invention, after the inner wall of the bottle body is unfolded, the guide rail is a straight line inclined from top to bottom.

[0011] As a further improvement of the present invention, after the inner wall of the bottle body is unfolded, the guide rail is a smooth curve inclined from top to bottom.

[0012] As a further improvement of the present invention, the slope of the smooth curve decreases from top to bottom.

[0013] As a further improvement of the present invention, it further comprises a pad placed in the bottle body, wherein the pad is provided with a through hole for facilitating the passage of the liquid sample.

[0014] As a further improvement of the present invention, the upper surface of the pad is provided with a protrusion or a depression.

[0015] As a further improvement of the present invention, the guide rail spirally descends from one-sixth to one full circle of the inner wall of the bottle body.

[0016] A second object of the present invention is to address the deficiencies of the prior art and provide a liquid sample collection device for collecting liquid samples from humans or animals.

[0017] The above-mentioned object of the present invention is achieved through the following technical solutions:

[0018] A liquid sample collection device includes a liquid sample collection bottle and a sampler, wherein the liquid sample collection bottle includes a bottle body, the bottle body includes an inner wall and an outer wall, the inner wall includes a cylindrical portion, and the sampler includes a rod and a liquid drawing portion, wherein the liquid drawing portion is connected to the lower end of the rod, wherein: the cylindrical portion of the inner wall of the bottle body is provided with a guide rail that tilts from top to bottom and spirally descends, and the lower end of the rod body is provided with a guide groove. After the lower end of the rod of the sampler is inserted into the liquid sample collection bottle, the guide groove at the lower end of the rod body cooperates with the guide rail on the inner wall of the bottle body to guide the lower end of the rod of the sampler to spirally descend in the liquid sample collection bottle.

[0019] As a further improvement of the present invention, the cross section of the guide rail on the inner wall of the bottle body is rectangular, triangular, trapezoidal or arc-shaped, and the portion with a larger cross section of the guide rail is located on the inner wall of the bottle body.

[0020] As a further improvement of the present invention, after the inner wall of the bottle body of the liquid sample collecting bottle is unfolded, the guide rail is a straight line inclined from top to bottom.

[0021] As a further improvement of the present invention, after the inner wall of the bottle body of the liquid sample collecting bottle is unfolded, the guide rail is a smooth curve inclined from top to bottom.

[0022] As a further improvement of the present invention, the slope of the smooth curve decreases from top to bottom.

[0023] As a further improvement of the present invention, it also includes a pad placed in the liquid sample collection bottle, the pad is provided with a through hole for facilitating the passage of the liquid sample, and then the liquid-drawing part of the sampler is squeezed during the process of the lower end of the rod of the sampler spirally descending in the liquid sample collection bottle.

[0024] As a further improvement of the present invention, the pad and the liquid-drawing portion of the sampler are provided with mutually matching protrusions and depressions.

[0025] As a further improvement of the present invention, the bottom of the liquid-drawing part is hardened so that it has a higher hardness than other parts of the liquid-drawing part, thereby being more conducive to reducing the slippage between the bottom of the liquid-drawing part and the upper surface of the pad.

[0026] As a further improvement of the present invention, the guide rail spirally descends from one-sixth to one full circle of the inner wall of the bottle body of the liquid sample collection bottle.

[0027] As a further improvement of the present invention, the guide rails and guide grooves that cooperate with each other form a pair, or are evenly distributed in two, three, four, five or six pairs.

[0028] As a further improvement of the present invention, the distance between the bottom of the guide rail and the upper surface of the pad is greater than or equal to 2.5 mm and less than or equal to 35.0 mm, and the lower end of the rod of the sampler can be snapped onto the bottom of the guide rail.

[0029] As a further improvement of the present invention, the lower surface of the bottom of the guide rail and the upper surface of the lower end of the rod of the sampler each include a mutually parallel inclined surface. During the forward rotation of the sampler, the pair of inclined surfaces further guide the bottom of the guide rail to squeeze the lower end of the rod of the sampler downward.

[0030] The third purpose of the present invention is to provide a method for collecting liquid samples for collecting liquid samples from humans or animals in response to the deficiencies of the prior art.

[0031] The above-mentioned object of the present invention is achieved through the following technical solutions:

[0032] A method for collecting a liquid sample is provided, wherein a liquid sample collecting device is provided, the liquid sample collecting device comprising a sampler and a liquid sample collecting component, wherein an inclined and spirally descending guide mechanism is provided between the sampler and the liquid sample collecting component for guiding the sampler to spirally descend within the liquid sample collecting component. The method comprises the following steps:

[0033] A. Allow the sampler's liquid drawing portion to draw a predetermined amount of liquid sample;

[0034] B. Insert the liquid-drawing portion of the sampler into the liquid sample collecting component so that the inclined guide groove of the sampler corresponds to the inclined and spirally descending guide rail on the inner wall of the liquid sample collecting component;

[0035] C. Push the sampler downward. Under the guidance of the guide groove and the guide rail, the sampler spirally descends in the liquid sample collection component, thereby squeezing the liquid-absorbing part of the sampler until the liquid-absorbing part is fully squeezed;

[0036] D. Make the sampler spiral upward in the reverse direction, remove the sampler, and seal the liquid sample collection component.

[0037] As a further improvement of the present invention, the liquid sample collection device is as disclosed in the second embodiment of the present invention.

[0038] As a further improvement of the present invention, the distance between the bottom of the guide rail on the inner wall of the liquid sample collection component and the upper surface of the pad is greater than or equal to 2.5 mm and less than or equal to 35.0 mm; between the above steps C and D, when the upper surface of the lower end of the sampler rod is lower than the bottom of the guide rail, the step of further rotating the sampler in the forward direction until the lower end of the sampler rod is snapped onto the bottom of the guide rail is included.

[0039] A fourth object of the present invention is to provide a detection device for collecting liquid samples from humans or animals in response to the deficiencies of the prior art.

[0040] The above-mentioned object of the present invention is achieved through the following technical solutions:

[0041] A detection device includes a liquid sample collection device and a detection plate. The liquid sample collection device includes a liquid sample collection component and a sampler, wherein the liquid sample collection component includes a cylindrical inner wall, and the sampler includes a rod and a liquid drawing part, wherein the liquid drawing part is connected to the lower end of the rod, wherein: the cylindrical inner wall is provided with a guide rail that tilts and spirally descends from top to bottom, and the lower end of the rod is provided with a guide groove. After the lower end of the rod of the sampler is inserted into the liquid sample collection component, the guide groove at the lower end of the rod cooperates with the guide rail of the cylindrical inner wall to guide the lower end of the rod of the sampler to spirally descend in the liquid sample collection component, thereby squeezing the liquid drawing part of the sampler. The detection plate includes a detection component, and the detection component is used to provide detection result information.

[0042] As a further improvement of the present invention, the liquid sample collecting component and the detection plate or a component of the detection plate are independent elements separated from each other.

[0043] As a further improvement of the present invention, the liquid sample collecting component is installed on the detection plate or a component of the detection plate.

[0044] Beneficial effects

[0045] The present invention provides a guide rail that is inclined and spirally descends from top to bottom on the inner wall of the liquid sample collection bottle, and a guide groove is provided at the lower end of the sampling rod. After the sampler's liquid-drawing portion has drawn sufficient liquid sample, it is inserted into the sampling bottle. Under the mutual cooperation of the guide rail and the guide groove, the lower end of the sampler's rod is guided to drive the liquid-drawing portion to perform a spiral downward motion in the sampling bottle, thereby producing a squeezing effect on the liquid-drawing portion, thereby fully squeezing out the liquid sample drawn by the liquid-drawing portion. Compared with the prior art, the present invention has a higher liquid sample extrusion rate. When the liquid-drawing portion draws the same liquid sample, more liquid sample can be squeezed out for testing, thereby more easily meeting the minimum amount of liquid sample required for testing, thereby improving the success rate of testing and the accuracy of the test results. BRIEF DESCRIPTION OF THE DRAWINGS

[0046] Figure 1 It is a schematic plan view of the liquid sample collection bottle of the present invention.

[0047] Figure 2 for Figure 1 Schematic diagram of the cross section along line AA.

[0048] Figure 3 This is a schematic plan view of the backing plate in the liquid sample collection bottle of the present invention.

[0049] Figure 4 for Figure 1 Top view of .

[0050] Figure 5Schematic diagram of a plan view of the liquid sample collection device of the present invention (the sampler is not inserted into the liquid sample collection bottle).

[0051] Figure 6 for Figure 5 Schematic diagram of the local section along line AA.

[0052] Figure 7 and Figure 5 Similar, but the sampler is inserted into the liquid sample collection bottle in its initial position (the water-absorbing part has not yet been squeezed).

[0053] Figure 8 for Figure 7 Schematic diagram of the cross section along line AA.

[0054] Figure 9 for Figure 8 A partial enlarged view of part "A" in the middle.

[0055] Figure 10-12 for Figure 9 Schematic diagram of the design change.

[0056] Figure 13 It is a partially expanded plan view of the cylindrical portion of the inner wall of the liquid sample collection bottle of the present invention.

[0057] Figure 14 yes Figure 13 Schematic diagram of the design change.

[0058] Figure 15 and Figure 7 Similar, but the probe is inserted into its final position in the liquid sample collection bottle (the wicking part has been fully squeezed).

[0059] Figure 16 for Figure 15 Schematic diagram of the cross section along line AA.

[0060] Figure 17 for Figure 16 Schematic diagram of the design change.

[0061] Figure 18 for Figure 17 An enlarged schematic diagram of the local “B” in FIG.

[0062] Figure 19 This is a sectional view from another local angle showing the cooperation between the guide rail on the liquid sample collection bottle and the lower part of the sampler.

[0063] Figure 20 and Figure 19 Similar, but the sampler is Figure 19 Continue to twist at a certain angle based on the

[0064] Figure 21 and Figure 8 Similarly, another design variation of the present invention is shown.

[0065] Figure 22 for Figure 21 An enlarged schematic diagram of the part “C” in the figure.

[0066] Figure 23 for Figure 22 Change design drawing.

[0067] Figure 24-29 These are six specific embodiments of the cooperation between the guide rail and the guide groove of the liquid sample collection device of the present invention.

[0068] Figure 30 Schematic diagram of the detection device of the present invention in use.

[0069] Figure 31 for Figure 30 Schematic diagram of the test results of the test board shown.

[0070] Figure 32 This is a schematic diagram of another embodiment of the detection device of the present invention in use.

[0071] Figure 33 for Figure 32 Schematic diagram of the test results of the test board shown. DETAILED DESCRIPTION

[0072] The present invention will be described in further detail with reference to the accompanying drawings and specific embodiments.

[0073] The above-mentioned specific implementation methods are used to illustrate the present invention and are only preferred embodiments of the present invention, rather than limiting the present invention. Any modifications, equivalent substitutions, improvements, etc. made to the present invention within the spirit of the present invention and the scope of protection of the claims shall fall within the scope of protection of the present invention.

[0074] Explanation of terms

[0075] If the patent specification of this invention (including claims and abstract) explains the terms used therein, the explanation in this patent specification shall prevail; if there is no explanation, the general meaning in this technical field shall prevail.

[0076] Cylinder: The cylinder of the present invention refers to a cylindrical object with a circular or approximately circular cross-section, and with equal or approximately equal areas across all cross-sections. The cylinder of the present invention also includes a cone with its tip truncated, i.e., a cone with a longitudinal section passing through its axis that is an isosceles trapezoid or a nearly isosceles trapezoid, but preferably, the angle between the hypotenuse and the height of the trapezoid does not exceed 15 degrees. In short, any cylindrical object deemed by those skilled in the art to be capable of achieving the objectives of the present invention, resolving the technical problems to be solved, and achieving the beneficial effects of the present invention is included within the scope of the cylinder of the present invention.

[0077] Cylindrical portion: The portion having the shape or structure of a cylinder of the present invention.

[0078] Liquid sample collection bottle: also known as liquid sample collection component, refers to a bottle-shaped object, cup-shaped object, cylindrical object, and any object or part of an object with a cylindrical inner wall used to collect liquid samples.

[0079] Spiral descent: Also known as spiral descent, this is a 3D, smooth curve that gradually descends from a high point to a low point on the inner wall of a cylinder. The spiral can range from a fraction of a turn to a full turn or several turns.

[0080] Rectangle, triangle, trapezoid: includes both the mathematical concept of rectangle, triangle, trapezoid and approximate rectangle, triangle and trapezoid.

[0081] Forward: refers to the direction opposite to reverse, but forward does not specifically refer to clockwise, but refers to either clockwise or counterclockwise. When forward refers to clockwise, reverse refers to counterclockwise; conversely, when forward refers to counterclockwise, reverse refers to clockwise.

[0082] Twisting: squeezing and twisting at the same time, that is, the two ends of an object move closer to each other while also rotating in opposite directions, producing an effect similar to wringing a wet towel.

[0083] The liquid-drawing part is fully squeezed: this means that the liquid-drawing part is squeezed under normal human power to achieve the effect of basically draining the liquid in the liquid-drawing part (the liquid drainage rate is significantly higher than that of the prior art).

[0084] See also Figure 1 、 Figure 2As shown, the present invention provides a liquid sample collection bottle 10 for collecting liquid samples such as saliva, blood, urine, and sweat from humans or animals. After processing, the content of a certain substance or substances in these liquid samples is detected using biological detection methods (including immunological and non-immunological detection methods), thereby obtaining physiological parameter indicators of the human or animal being tested. Currently, scientists have developed products and detection methods for testing human or animal saliva (including processed saliva) as samples. A key step in such detection methods is how to collect saliva from the human or animal being tested. The purpose of the present invention is to provide a novel liquid sample collection bottle for collecting human or animal saliva, a liquid sample collection device, and a method for collecting liquid samples using such a liquid sample collection device.

[0085] Invention 1: Liquid sample collection bottle

[0086] See also Figure 1 、 Figure 2 As shown, the liquid sample collection bottle 10 of the present invention includes a bottle body 12, which includes an inner wall 14 and an outer wall 16. The inner wall 14 includes a cylindrical portion 18 (i.e., at least a portion of the inner wall 14 is cylindrical). The cylindrical portion 18 is provided with a guide rail 20 that is inclined and spirally descends from top to bottom. The guide rail 20 protrudes from the inner wall 14 to the center of the cylinder by an appropriate distance and is attached to the inner wall 14 in a spiral coil. Figure 9-12 As shown, the cross section of the guide rail 20 is rectangular (including square), triangular, trapezoidal or arc-shaped (including partially circular or partially elliptical), and the portion of the guide rail 20 with a larger cross section (such as Figure 9-12 The guide rail 20 is located on the inner wall 14 of the bottle body 12 (as shown by the dotted line in FIG).

[0087] See also Figure 13 As shown, in one embodiment, after the cylindrical portion 18 of the inner wall 14 of the bottle body 12 is unfolded, the guide rail 20 on the inner wall 14 is inclined straight from top to bottom. The angle "A" between the inclined straight line and the horizontal plane is greater than or equal to 30 degrees and less than or equal to 75 degrees. The preferred angle "A" is 60 degrees and 45 degrees. Figure 14 As shown, in another embodiment, after the inner wall 14 of the bottle body 12 is unfolded, the guide rail 20 on the inner wall 14 forms an inclined smooth curve from top to bottom. The slope of the smooth curve gradually decreases (i.e., the angle between the tangent of the smooth curve and the horizontal plane gradually decreases). In this embodiment, preferably, the angle "C" between the tangent of the top of the guide rail 20 and the horizontal plane is 75 degrees, and the angle "B" between the tangent of the bottom of the guide rail 20 and the horizontal plane is 30 degrees.

[0088] like Figure 2As shown, the liquid sample collection bottle 10 further includes a pad 22 placed in the bottle body 12. The pad 22 is provided with a plurality of through holes 24 for the liquid sample to flow through. The pad 22 is disc-shaped and has a thickness of about 2.0-5.0 mm and is generally made of hard plastic. Figure 1 and Figure 2 In the illustrated embodiment, the bottle body 12 comprises an upper portion and a lower portion. The upper portion is significantly larger than the lower portion, and a shoulder 26 is formed at the junction of the two portions. A backing plate 22 is placed on and supported by the shoulder 26. In one embodiment, when the area of ​​the shoulder 26 is twice or greater than the cross-sectional area of ​​the inner diameter of the lower portion of the bottle body, the backing plate 22 may be omitted, i.e., the backing plate 22 is not required. Figure 3 is a plan view of the pad 22, Figure 4 2 is a top view of the backing plate 22 after being placed in the bottle body 12. In one embodiment, the upper surface of the backing plate 22 is provided with a depression (the depression can also be a through hole 24, such as Figure 22 as shown) or raised (as Figure 23 The guide rail 20 is inclined and spirally descends at least one-sixth of the inner wall 18 of the bottle body, but preferably does not exceed one circle (it does not necessarily have to exceed one circle, and in some cases, it can also be several circles). A guide rail 20 can be provided on the inner wall 18 of the cylindrical body (as shown). Figure 24 As shown), two, three, four, five and six guide rails 20 can also be evenly arranged (as shown Figure 25-29 As shown), however, the number of guide rails 20 should not limit the scope of protection of the present invention.

[0089] Invention 2: Liquid Sample Collection Device

[0090] See also Figure 5-8 As shown, the present invention also provides a liquid sample collection device 100, which includes the liquid sample collection bottle 10 as described in the first invention (to avoid repetition, the contents of the first invention are all incorporated into the second invention) and a sampler 50. The sampler 50 includes a rod 52 and a liquid drawing portion 56 connected to the lower end 54 of the rod. The liquid drawing portion 56 is made of a material with excellent water absorption and drainage properties, such as sponge, cotton wool, gauze, special fiber, etc. The rod 52 is made of a hard material, and the lower end 54 of the rod is in the shape of a round cake, and a guide groove 58 is provided on its outer periphery. The shape and size of the guide groove 58 correspond to the guide rail 20 on the inner wall 14 of the bottle body ( Figure 5 and Figure 6The guide groove 58 is shown to be inclined, and the direction of inclination is consistent with that of the guide rail 20. This allows the guide rail 20 to slide freely within the guide groove 58 while also cooperating to guide the lower end 54 of the rod in a spiral downward motion. When the lower end 54 of the rod of the sampler 50 is inserted into the liquid sample collection bottle 10, the guide groove 58 of the lower end 54 of the rod cooperates with the guide rail 20 on the inner wall 14 of the bottle, guiding the lower end 54 of the rod of the sampler 50 in a spiral downward motion within the liquid sample collection bottle. When the bottom of the liquid-drawing portion 56 presses against the upper surface of the pad 22, the surface friction between the two reduces the relative sliding of the bottom of the liquid-drawing portion 56 relative to the pad 22. However, the guide rail 20 guides the lower end 54 of the rod to drive the upper part of the liquid-drawing portion 56 to continue to twist and descend, so that the lower end 54 of the rod presses downward while twisting the liquid-drawing portion 56, producing a squeezing effect of the liquid-drawing portion 56 (similar to wringing a wet towel), thereby more thoroughly draining the liquid sample from the liquid-drawing portion 56 into the liquid sample collection bottle 10 and mixing with the lysate 60 (such as Figure 8 ) to form a mixture of lysate and liquid sample 62 (as shown Figure 16 shown).

[0091] As described in the first invention, after the cylindrical portion 18 of the inner wall 14 of the bottle body 12 is unfolded, the guide rail 20 on the inner wall 14 forms an inclined straight line or a smooth curve from top to bottom. The smooth curve of the guide rail facilitates the guide rail 20 and the guide groove 58 to guide the lower end 54 of the rod to accelerate the descent at the beginning of the descent, thereby exerting a stronger downward pressure on the liquid-drawing portion. Near the end of the descent, the guide rail 20 and the guide groove 58 guide the lower end 54 of the rod to exert a stronger twist, thereby producing a better squeezing effect on the liquid-drawing portion 56, thereby squeezing out more liquid sample from the liquid-drawing portion 56.

[0092] like Figure 21-23 As shown, in order to reduce the relative slip between the bottom of the liquid-drawing portion 56 and the upper surface of the backing plate 22, mutually cooperating protrusions 28 and recesses 30 are provided on the upper surface of the backing plate 22 and the bottom of the liquid-drawing portion 56 of the sampler. The cooperation between the protrusions and recesses reduces the relative slip between the bottom of the liquid-drawing portion 56 and the upper surface of the backing plate 22, thereby enhancing the squeezing effect on the liquid-drawing portion 56. The recesses 30 (which may also be through-holes 24) may be provided on the upper surface of the backing plate 22 and the protrusions 28 (such as through-holes 24) may be provided on the bottom of the liquid-drawing portion 56 of the sampler. Figure 22 As shown), a protrusion 28 may be provided on the upper surface of the pad 22 and a recess 30 may be provided at the bottom of the liquid drawing portion 56 of the sampler (as shown). Figure 23Preferably, the bottom of the liquid-drawing portion 56 is hardened to have a higher hardness than other portions of the liquid-drawing portion. This further helps reduce slippage between the bottom of the liquid-drawing portion 56 and the upper surface of the backing plate 22, thereby improving the squeezing effect of the liquid-drawing portion 56 and thereby increasing the liquid sample discharge rate of the liquid-drawing portion 56.

[0093] like Figure 24 As shown, the guide rail 20 and the guide groove 58 that cooperate with each other are a pair. Figure 25-29 As shown, in order to improve the smoothness of the guidance, the mutually cooperating guide rails 20 and guide grooves 58 can also be evenly distributed in two, three, four, five or six pairs, which can improve the squeezing effect of the liquid drawing portion 56 and further improve the efficiency of squeezing the liquid sample from the liquid drawing portion 56.

[0094] like Figure 2 、 6 As shown, the distance "L" between the bottom of the guide rail 20 and the upper surface of the pad 22 is greater than or equal to 2.5 mm and less than or equal to 35.0 mm. This distance "L" enables the lower end 54 of the rod of the sampler 50 to be snapped onto the bottom of the guide rail 20 (e.g. Figure 17 、 18 At this time, the liquid drawing portion 56 is in a twisted and compressed state.

[0095] like Figure 19 、 20 As shown, the lower surface of the bottom of the guide rail 20 and the upper surface of the lower end 56 of the rod of the sampler 50 are a pair of inclined surfaces 32, 34. Figure 19 、 20 During the process of rotating the sampler (indicated by the direction of the arrow), the pair of inclined surfaces has a guiding function and causes the bottom of the guide rail 20 to further press the lower end 54 of the rod of the sampler 50 downward. After the operator lets go, the lower end of the rod of the sampler is still pressed by the bottom of the guide rail 20.

[0096] Invention 3: A method for collecting liquid samples

[0097] The present invention also provides a method for collecting a liquid sample, comprising a liquid sample collecting component 10 and a sampler 50, wherein an inclined and spirally descending guide mechanism is provided between the liquid sample collecting component 10 and the sampler 50 for guiding the sampler 50 to spirally descend within the liquid sample collecting component 10. The method comprises the following steps:

[0098] A. Allow the liquid drawing portion 56 of the sampler 50 to draw a predetermined amount of liquid sample;

[0099] B. Insert the lower end 54 of the sampler rod into the liquid sample collecting component 10 to form the guiding mechanism therebetween;

[0100] C. Push the sampler 50 downward. Under the guidance of the guide mechanism, the liquid-drawing portion 56 of the sampler spirally descends in the liquid sample collection bottle 10, thereby squeezing the liquid-drawing portion 56 of the sampler until the liquid-drawing portion 56 is fully squeezed.

[0101] D. Make the sampler 50 spiral upward in the reverse direction, take out the sampler 50 , and seal the liquid sample collection bottle 10 .

[0102] As a further improvement, the guiding mechanism includes a guide rail 20 and a guide groove 58 (or a guide groove 20 and a guide rail 58 ) respectively provided at the lower ends of the rods of the liquid sample collecting component 10 and the sampler 50 .

[0103] As a further improvement, the distance between the bottom of the guide rail 20 on the inner wall of the liquid sample collection bottle 10 and the upper surface of the backing plate 22 is greater than or equal to 2.5 mm and less than or equal to 35.0 mm. Between steps C and D, after the upper surface of the lower end 54 of the sampler's stem is lower than the bottom of the guide rail 20, the method further includes the step of rotating the sampler 50 in the forward direction until the lower end 54 of the sampler's stem is locked to the bottom of the guide rail 20. This allows the lower end 54 of the sampler's stem to remain at the bottom of the guide rail 20, thereby more fully squeezing the liquid-drawing portion 56 and improving the liquid sample removal rate.

[0104] Invention 4: A detection device

[0105] Figure 30 、 31The figure shows the use and test results of a detection device according to the present invention. The detection device 200 includes a liquid sample collection device 100 (the structure is similar to that described in "Invention 2," except for the addition of a cap 11) and a detection plate 210. The liquid sample collection device 100 comprises a liquid sample collection component 10 and a sampler 50. The liquid sample collection component 10 includes a cylindrical inner wall 14. The sampler 50 comprises a stem 52 and a liquid-drawing portion 56, which is connected to the stem's lower end 54. The cylindrical inner wall 14 is provided with a guide rail 20 that tilts downward and spirals downward. The stem's lower end 54 is provided with a guide groove 58 that tilts in the same direction as the guide rail 20. After the stem's lower end 54 is inserted into the liquid sample collection component 10, the guide groove 58 cooperates with the cylindrical inner wall's guide rail 20, guiding the stem's lower end 54 as it spirals downward within the liquid sample collection component 10, thereby squeezing the sampler's liquid-drawing portion 56. The detection board 210 includes a detection component 220, which is used to give the detection result information. The detection board 210 is provided with a sample addition area 212 and a detection result display area 214 to facilitate observation of the detection results. The detection component 220 has a T line and a C line in the detection result display area 214. Before the detection, the T line and the C line are invisible. Within a period of time after the detection, the following situations will generally occur: A. If the C line is not displayed (regardless of whether the T line is displayed), it means that the test has failed; B. If the C line is displayed but the T line is not displayed, it means that the test result is negative; C. If both the C line and the T line are displayed, it means that the test result is positive, and if the T line is thick, it is a strong positive, and if the T line is light, it is a weak positive. In such cases Figure 30 、 31 In the illustrated embodiment, the liquid sample collecting component 10 and the detection plate 210 or components of the detection plate 210 are independent components separated from each other, and the structures of the liquid sample collecting component 10 and the sampler 50 are basically the same as those of the "Invention 2".

[0106] Figure 32 、 33 It shows the use status and detection results of another detection device 200 of the present invention. Figure 30 、 31The difference in the illustrated embodiment is that the liquid sample collection component 10 is mounted on the test plate 210 or a component of the test plate 210. The liquid sample collection component 10 and the test plate 210 or a component of the test plate 210 can be manufactured separately and then assembled together, or they can be integrally molded with the test plate 210 or a component of the test plate 210 and then assembled together to form a single unit. The cylindrical inner wall 14 of the liquid sample collection component 10 is provided with a guide rail 20 that slopes downward and spirals downward. The lower end 54 of the rod is provided with a guide groove 58 that slopes in the same direction as the guide rail 20. After the lower end 54 of the sampler rod is inserted into the liquid sample collection component 10, the guide groove 58 cooperates with the guide rail 20 on the cylindrical inner wall to guide the lower end 54 of the sampler rod as it spirals downward within the liquid sample collection component 10, thereby squeezing the sampler's liquid-drawing portion 56. The basic principle and specific structure are as disclosed in "Invention 2."

[0107] experiment

[0108] The present invention uses a sponge swab as an example of the sampler 50 to collect human saliva, and uses a comparative experimental method to verify the beneficial effects of the present invention.

[0109] Experimental methods:

[0110] Step 1: Use 10 sponge swabs of the present invention, numbered 1-10, and weigh each sponge swab before drawing the liquid using an electronic scale accurate to one thousandth of a gram. Record the weight in column "A" in the table below (weights are in grams, the same below).

[0111] Step 2: Use the 10 sponge swabs to collect saliva from 10 volunteers. Once the sponge tips are saturated, weigh each sponge swab and record the weight in column "B" in the table below.

[0112] Step 3: Insert each of the 10 sponge swabs into the existing liquid sample collection bottle. Squeeze the sponge tip vertically downward to fully squeeze out the saliva. Weigh each sponge tip and record the weight in column "C" in the table below.

[0113] Step 4: Insert the ten sponge swabs obtained after step 3 into the liquid sample collection bottle of the present invention. After fully squeezing out the saliva from the sponge tips using the method of the present invention, weigh the sponge tips and record the weight in the "D" column of the table below.

[0114] Step 5: Use the formulas in the table below to calculate the amount of liquid drawn up by the 10 sponge swabs (E), the amount of sample squeezed out using the existing method (F), the amount of sample squeezed out using the method of the present invention (G), the percentage of sample squeezed out using the existing method (H), the percentage of sample squeezed out using the method of the present invention (I), and the percentage improvement of the present invention over the existing method (J).

[0115] Step 6: Calculate the average value of the percentage improvement of the present invention relative to the existing method.

[0116]

[0117] Table 1. Comparative experimental data of existing sampling method and sampling method of the present invention

[0118] According to the experimental data in Table 1, the sampling method of the present invention increases the sampling volume by an average of 31.30% compared with the existing sampling method. This experiment shows that the beneficial effects of the sampling device and sampling method of the present invention are very outstanding.

[0119] In biological sample testing procedures, the sample collection bottle of the present invention, when used in conjunction with a sampling stick, can fully collect the sample from the stick and simultaneously complete pre-processing steps such as sample lysis. This improves the utilization rate of sampled specimens in testing projects requiring sample collection with a sampling stick, such as those for allergens, tumor markers, gonadal markers, thyroid function markers, infectious disease markers, diabetes markers, and liver fibrosis markers.

Claims

1. A liquid sample collection device comprising a liquid sample collection bottle and a sampler, wherein the liquid sample collection bottle comprises a bottle body, the bottle body comprises an inner wall and an outer wall, the inner wall comprises a cylindrical portion, and the sampler comprises a stem and a liquid-sucking portion, the liquid-sucking portion being connected to the lower end of the stem, characterized in that: The cylindrical portion of the inner wall of the bottle body is provided with a guide rail that tilts from top to bottom and spirally descends, and the lower end of the rod is provided with a guide groove, wherein, after the inner wall of the bottle body is unfolded into a plane, the guide rail that tilts from top to bottom and spirally descends is a smooth curve, and the angle between the tangent of the smooth curve and the horizontal plane is greater than or equal to thirty degrees and less than or equal to seventy-five degrees, and the slope of the smooth curve decreases from top to bottom. After the lower end of the rod of the sampler is inserted into the liquid sample collection bottle, the guide groove at the lower end of the rod cooperates with the guide rail of the inner wall of the bottle body to guide the lower end of the rod of the sampler to spirally descend in the liquid sample collection bottle, thereby squeezing the liquid drawing part of the sampler.

2. The liquid sample collection device according to claim 1, wherein: It also includes a pad placed in the liquid sample collection bottle, which is provided with a through hole for facilitating the passage of the liquid sample, so that the liquid-drawing part of the sampler can be squeezed when the lower end of the sampler rod spirally descends in the liquid sample collection bottle.

3. The liquid sample collection device according to claim 2, wherein: The pad and the liquid drawing part of the sampler are respectively provided with protrusions and depressions that match each other.

4. The liquid sample collection device according to claim 3, wherein: The bottom of the liquid-absorbing part is hardened so as to have a higher hardness than other parts of the liquid-absorbing part.

5. The liquid sample collection device according to claim 4, wherein: The distance between the bottom of the guide rail and the upper surface of the pad is greater than or equal to 2.5 mm and less than or equal to 35.0 mm, and the lower end of the rod of the sampler can be snapped onto the bottom of the guide rail.

6. The liquid sample collection device according to claim 5, wherein: The lower surface of the guide rail bottom and the upper surface of the lower end of the sampler rod each include a mutually parallel inclined surface. During the forward rotation of the sampler, the pair of inclined surfaces further guide the guide rail bottom to press the lower end of the sampler rod downward.

7. A detection device comprising a liquid sample collection device and a detection plate, wherein the liquid sample collection device comprises a liquid sample collection component and a sampler, wherein the liquid sample collection component comprises a cylindrical inner wall, and the sampler comprises a rod and a liquid absorbing portion, wherein the liquid absorbing portion is connected to the lower end of the rod, characterized in that: The inner wall of the cylinder is provided with a guide rail that tilts from top to bottom and spirally descends, and the lower end of the rod is provided with a guide groove, wherein, after the inner wall of the cylinder is unfolded into a plane, the guide rail that tilts from top to bottom and spirally descends is a smooth curve, and the angle between the tangent of the smooth curve and the horizontal plane is greater than or equal to thirty degrees and less than or equal to seventy-five degrees, and the slope of the smooth curve decreases from top to bottom. After the lower end of the rod of the sampler is inserted into the liquid sample collection component, the guide groove at the lower end of the rod cooperates with the guide rail on the cylindrical inner wall to guide the lower end of the rod of the sampler to spirally descend in the liquid sample collection component, thereby squeezing the liquid-drawing part of the sampler. The detection plate includes a detection component, and the detection component is used to provide detection result information.

8. The detection device according to claim 7, wherein: The liquid sample collecting component and the detection plate are independent components separated from each other.

9. The detection device according to claim 7, wherein: The liquid sample collecting component is installed on the detection plate.

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