Application flow path for water treatment or detection

Abstract

The application relates to the field of liquid treatment, and discloses an application flow path for water treatment or detection, which comprises a plurality of containers for containing liquid to be extracted, the through-flow pipes of each of the containers are communicated to one common pipe, or the through-flow pipes of part of the containers are communicated to one common pipe and the through-flow pipes of the other part of the containers are communicated to another common pipe, and a peristaltic pump is arranged in series on the through-flow pipe of each container; at least one outer branch, each of the common pipes is communicated to the atmosphere through the outer branch provided with a peristaltic pump in series, for pumping in and / or pumping out air and / or discharging liquid.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of liquid treatment, analysis or detection, and in particular, to an application flow path for water treatment or detection. BACKGROUND

[0002] Currently, in many technical fields, the treatment and / or analysis of liquids is involved. For example, in the medical field, the food field, laboratory analysis, agriculture, forestry, animal husbandry, fishery and other fields, the analysis of samples requires quantitative treatment of the sample to be tested and reagents. For another example, in the field of environmental protection, water quality detection requires intercepting a small amount of sample and detecting and analyzing the small sample. The accuracy of the amount of liquid to be tested has a direct and important impact on the detection result. If the sample cannot be accurately intercepted or the volume of the liquid is not accurately known, it will result in a large error in the detection result.

[0003] Traditionally, many analysis instruments or liquid treatment devices can accurately add a small volume of liquid (such as 0.05 milliliters to 2 milliliters), but the object to be detected is usually a relatively clear and clean liquid after pretreatment such as flocculation, precipitation and filtration in a laboratory state, and the cost of liquid pretreatment device and manual operation is usually high.

[0004] This traditional solution is difficult to meet the actual working condition requirements of the current industry, because it is difficult to ensure the cleanliness of the liquid to be tested in some actual working conditions. On the other hand, once the liquid to be tested is pretreated, the clean liquid is obviously different from the actual liquid in the first field (such as COD, total phosphorus, total nitrogen, etc. in water quality detection), which may affect the accuracy of the measurement, and the suspended solids or impurities in the liquid may also block the pretreatment pipeline. For another example, in the field of online monitoring in harsh conditions, such as online detection of electroplating treatment liquid, wet smelting mineral solution, environmental pollution wastewater, etc., the traditional technical solution cannot realize accurate quantitative detection of the harsh liquid to be tested in such working conditions. In particular, there is a lack of a micro-liquid (such as 0.05-2 milliliters) quantitative technology with relatively low cost and relatively long time maintenance or even maintenance-free.

[0005] In addition, a typical quantitative metering flow path currently widely used in the field of analytical instruments and liquid handling is a "sequential injection" liquid metering technology. This flow path technology has good stability, but in the past decade, with the emergence of new requirements for low cost, high precision, and simultaneous consideration of micro-liquid volume (such as 0.05-2ml) and conventional liquid volume (such as 2-10ml) and rapidity of metering and detection, and a series of other harsh new requirements for instruments and equipment, several inherent defects of the traditional sequential injection liquid metering technology have become increasingly apparent: for example, first, due to the need to use a multi-channel switching valve (or valve group) and a liquid metering and detection device, the cost of the flow path device in such a traditional device is relatively high; second, in the flow path scheme of such a traditional device, liquid injection and liquid discharge need to be sequentially performed in a transfer manner, so the operation steps are relatively complex and require a long time, which results in relatively low overall work efficiency; third, a more serious defect is that if the detection process requires continuous water sample and several different reagents under certain working conditions, the flow path in the traditional scheme can only sequentially meter these water samples and reagents in sequence, and sometimes the pipeline needs to be thoroughly cleaned when the next reagent is injected, which results in a long overall analysis process and seriously affects work efficiency; finally, in the flow path of the traditional device, the transfer pipeline has a long travel distance, which is easy to cause wall hanging or liquid residue in the conduit and device, thereby resulting in low measurement accuracy when processing micro-liquid volume.

[0006] Therefore, how to at least partially overcome at least one of the above technical defects in the traditional scheme has become an urgent technical problem to be solved in the field. SUMMARY

[0007] The application provides an application flow path for water treatment or detection, which comprises:

[0008] a plurality of containers for containing liquid to be extracted, the through-flow pipelines of each of the containers being connected to a common pipeline, or the through-flow pipelines of a part of the containers being connected to a common pipeline and the through-flow pipelines of another part of the containers being connected to another common pipeline, and a peristaltic pump being arranged in series on the through-flow pipeline of each container;

[0009] at least one external branch, each of the common pipelines being connected to the atmosphere through the external branch in which a peristaltic pump is arranged in series, for pumping in and / or pumping out air and / or discharging liquid.

[0010] Preferably, the common line and / or the outer branch is a fine channel, the inner diameter of which is 0.05mm to 5mm, preferably 0.1mm to 3mm, more preferably 0.2mm to 2mm; preferably, the through line is also a fine channel; or the through line is a fine channel within a predetermined length range extending from the connection point on the common line towards the container, the predetermined length range being at least 0.01mm.

[0011] Preferably, the application flow path comprises a reactor / dish, and the common line is connected to the reactor / dish.

[0012] Preferably, the opening of the common line is located at the bottom, middle or upper part of the reactor / dish; and / or the common line drops liquid into the reactor / dish through the opening above the top of the reactor / dish; and / or the liquid in the container is distilled water, cleaning liquid, water sample to be tested, standard solution or reagent.

[0013] Preferably, the through line of at least a part of the plurality of containers is connected to the same common line, and the opening of the common line is located at the bottom of the reactor / dish.

[0014] Preferably, the outer branch comprises a first outer branch, which is connected to an air / waste liquid bottle or an air / rinse water bottle from the common line, wherein the first outer branch is connected to the part of the common line between the end part away from the reactor / dish and the node connecting the container of reagent, or wherein the first outer branch is connected to the part of the common line between the end part away from the reactor / dish and the node connecting the container of distilled water, preferably, the first outer branch is connected to the end part of the common line away from the reactor / dish.

[0015] Preferably, the application flow path comprises a liquid detector, which is arranged in the part of the common line between the reactor / dish and the node of the through line and the common line closest to the reactor / dish.

[0016] Preferably, the outer branch comprises a second outer branch, which is connected to a waste liquid bottle from the common line, preferably, the second outer branch is connected to the part of the common line between the reactor / dish and the node of the through line and the common line closest to the reactor / dish.

[0017] Preferably, the outer branch comprises a third outer branch, which is connected to an air / rinse water bottle from the common line, wherein the third outer branch is connected to the part of the common line between the reactor / dish and the node connecting the container of reagent.

[0018] Preferably, the throughflow lines of at least two of the plurality of containers are connected to one common line and the throughflow lines of the other containers are connected to another common line, the openings of the common lines are arranged adjacent to the bottom opening of the reactor / dish, and the other common line is connected to and / or extends into the interior of the reactor / dish or above the opening thereof.

[0019] Preferably, a plurality of liquid dosing devices are connected to the one common line, the liquid dosing device comprising:

[0020] a container for containing the liquid to be extracted;

[0021] a throughflow line extending from the interior of the container to a branching point, the throughflow line being provided with a peristaltic pump in series;

[0022] a first branch connected to the throughflow line and extending from the branching point to a first port open to the atmosphere; and

[0023] a second branch connected to the throughflow line and extending from the branching point to a second port, the second branch being provided with a peristaltic pump or a stop valve in series,

[0024] wherein at least some of the plurality of liquid dosing devices share the first branch and / or share the second branch.

[0025] Preferably, the first branch and / or the second branch is a fine channel, the fine channel having a pore size of 0.05 mm to 5 mm, preferably 0.1 mm to 3 mm, and more preferably 0.5 mm to 2 mm; and preferably, the throughflow line is also a fine channel; or the throughflow line is a fine channel within a predetermined length range extending from the branching point towards the container, the predetermined length range being at least 0.01 mm.

[0026] Preferably, the common line is connected to a container containing a reagent and a throughflow line of air, respectively, and the other common line is connected to the other throughflow lines.

[0027] Preferably, the reactor / dish is provided with a detector for detecting the liquid level or the liquid volume in the interior of the reactor / dish, the detector being an electric medium sensor, a pressure sensor or an optical sensor.

[0028] By the technical solution of the present application, the working characteristics of the peristaltic pump and / or the stop valve can be utilized, and at least some of the following beneficial technical effects can be achieved.

[0029] For example, by employing a combination of peristaltic pump and / or stop valve, with simple control of the peristaltic pump and stop valve, the liquid to be metered into can be easily filled in the selected constant volume pipeline to be accurately measured by overflow, and at the same time, the air bubbles that may be generated at the beginning of the liquid inlet can also be eliminated by the method of overflow, so as to realize high-precision liquid inlet under micro-liquid volume. In addition to being able to accurately measure the volume of the liquid to be measured, the technical solution of the present application can also realize high-precision measurement and rapid liquid inlet of the liquid, and delivery of the liquid with high-precision volume to the subsequent processing container or process.

[0030] For another example, the flow path topology in the technical solution of the present application is very simple, the types of flow path devices required are less, and the devices are simple and easy to mass produce, some flow paths even only require one device (peristaltic pump) in addition to the conduit, so the cost is greatly reduced, the assembly is very simple during production and manufacturing, and the daily maintenance and repair are also very convenient during use.

[0031] In addition, in the technical solution of the present application, most of the devices used are currently widely used and produced in the industrial field (small and micro peristaltic pumps and stop valves), and a cheap fine channel is preferably used as the constant volume pipe. Such devices are not only cheap, but also stable and reliable in performance. Therefore, compared with the traditional scheme, the cost can be greatly reduced and good reliability can be obtained.

[0032] In addition, in the technical solution of the present application, as described above, high-precision constant volume measurement can be realized by using the flow path scheme design, and higher-precision liquid inlet operation can be realized by using the peristaltic pump (since the peristaltic pump pipe is preferably directly connected to the fine channel, compared with the stop valve, the peristaltic pump can more easily eliminate the dead volume interference problem of residual liquid).

[0033] In addition, in the present application, not only can various flow path schemes be easily expanded and modularly combined, but also a "concurrent micro-equivalent rapid liquid inlet technology" similar to "magazine loading" can be realized in some combined flow path schemes: in the traditional sequential liquid inlet mode (such as "sequential injection" liquid inlet technology), since the constant volume measuring device and the peristaltic pump can usually only have one, the water sample or reagent must be driven by the peristaltic pump to enter the constant volume measuring device in turn, and finally pushed or sucked into the specified container or pipeline; and in the preferred embodiment of the present application, by using the "pre-loaded" "concurrent micro-equivalent rapid liquid inlet technology" (such as the application of flow path Figure 21-24 、 Figure 33-42 , etc.), the water sample and various reagents can be pre-constant in the respective branches, and then driven by the pumps on the branches at the same time or in turn, or driven by the pump in the main pipeline in turn, and injected into the reactor / pan, greatly saving the total time for completing all reagent metering and subsequent cleaning.

[0034] In addition, the "sequential injection" liquid feeding technique requires that the water sample or reagent be first pumped into the quantitative tube for temporary volume adjustment, and then the water sample or reagent in the quantitative tube is pumped into the pre-determined container (such as a cuvette) for detection. After the detection is completed, the waste liquid needs to be discharged in a reverse process. Such operation not only takes time, but also increases the risk of residual liquid in the flow path. In the preferred embodiment of the present application, the flow path does not need to be provided with a liquid storage unit, and the flow path scheme in each combined flow path can independently allow the to-be-detected liquid (such as a water sample) and the reagent to directly enter the cuvette leading to the reaction container, so that the liquid feeding and volume metering can be completed at the same time, and the liquid discharging is also simpler, which only needs to continuously and rapidly discharge the liquid to the waste liquid outlet. Moreover, due to the improvement of the metering accuracy, the volume of the liquid fed by the present application is greatly reduced, and the flow path stroke is greatly shortened. Therefore, compared with the traditional method, the liquid feeding time is greatly shortened, and the work efficiency is improved; and since the core components such as the plunger pump and the metering quantitative tube are reduced, the cost is greatly reduced, and the size of the device is also reduced, thereby realizing miniaturization and portability.

[0035] Other features and advantages of the present application will be described in detail in the following specific embodiment part. BRIEF DESCRIPTION OF DRAWINGS

[0036] The accompanying drawings are included to provide a further understanding of the present application, and constitute a part of the specification, and are used together with the following specific embodiments to explain the present application, but do not constitute a limitation on the present application. In the drawings:

[0037] Figures 1A to 1E and Figures 2 to 10 are respectively schematic diagrams of various basic flow path schemes of the device for quantitatively processing liquid according to the present application.

[0038] Figures 11A to 11C and Figure 12 are respectively schematic diagrams of various basic flow path schemes of the device for quantitatively processing liquid according to the present application.

[0039] Figures 17 to 43 are respectively schematic diagrams of various reaction flow paths of the device for quantitatively processing liquid according to the present application.

[0040] Figure 44 is a schematic diagram for expressing the technical advantages of the fine channel in use in the technical scheme of the present application. DETAILED DESCRIPTION

[0041] In the technical solution of the present application, the basic flow path of the device for quantitatively processing liquid, the combination of the basic flow path, and various application flow paths are described. It can be understood that in actual engineering applications, various modes of liquid flow control can be realized by combining the flow path solution of the technical solution of the present application under the control of various elements in a computer system (such as an industrial computer, a single-chip microcomputer, etc.). The selection of the control unit and the program design can be selected according to the actual working conditions.

[0042] As described above, the technical solution of the present application can be applied to various technical fields related to liquid processing and / or analysis, such as the medical field, the food field, laboratory analysis, but is particularly suitable for water quality detection and analysis in the environmental protection field. For example, the technical solution of the present application is particularly suitable for a water quality analyzer.

[0043] The specific embodiments of the present application are described in detail below with reference to the accompanying drawings. It should be understood that the specific embodiments described herein are only used to illustrate and explain the present application, and are not used to limit the present application.

[0044] I. Definition of Terms

[0045] 1. Fine channel

[0046] In the preferred technical solution of the present application, a part of the flow path is designed as a fine channel. The common pipe and / or the outer branch are fine channels, the inner diameter of the fine channel is 0.05mm to 5mm, preferably 0.1mm to 3mm, and more preferably 0.2mm to 2mm; preferably, the through pipe is also a fine channel; or the through pipe is a fine channel within a predetermined length range extending from the connection point rb, rc, r1, …, rn on the common pipe towards the container Pb, Pc, Pr1, …, Prn; Ph1, …, Phn, and the predetermined length range is at least 0.01mm.

[0047] Preferably, the first branch 11 and / or the second branch 12 are fine channels, the aperture of the fine channel is 0.05mm to 5mm, preferably 0.1mm to 3mm, and more preferably 0.5mm to 2mm; preferably, the through pipe 10 is also a fine channel; or the through pipe 10 is a fine channel within a predetermined length range extending from the bifurcation point b1 towards the container P, and the predetermined length range is at least 0.01mm.

[0048] In addition, in the entire flow path, the fine channel generally has a uniform inner diameter; but within the range of precision allowed or the position of the setting element (such as a peristaltic pump or a stop valve, etc.), different inner diameters can also be designed.

[0049] The material of the fine channel includes, but is not limited to, various rubbers, plastics or metals, etc. The fine channel can be a fine tube, and commonly used tubes include silicone rubber tubes, fluororubber tubes, polytetrafluoroethylene tubes, etc.

[0050] It should be noted that, in this paper, for the convenience of description, the "channel" advantage is referred to as "pipe" or "catheter".

[0051] In the preferred technical solution of the present application, the fine channel design is based on the following reasons.

[0052] As described above, using the fine channel (combined with the simple control of the peristaltic pump and / or the stop valve) can not only achieve high-precision constant volume under micro-liquid volume, but also achieve high-precision micro-liquid feeding (such as 0.1-2 milliliters). For example, if a fine channel with an inner diameter of 0.5 mm and a length of 500 mm is selected for constant volume, the technical solution of the present application can easily achieve constant volume measurement of about 100 microliters (0.1 milliliter) of sewage, with a precision of ±2 microliters, and then the high-precision constant volume liquid can be delivered without residue. In addition, due to the use of the fine channel, the liquid sample with smaller volume can be processed and detected subsequently, greatly reducing the cost of reagents consumed.

[0053] More importantly, in the field of online monitoring under harsh conditions, the use of the above fine channel (the optimal selection of the inner diameter is 0.5-1.6 millimeters) has three major advantages. First, the fine channel is relatively easy to plug and repair, and the cost of regular replacement is very low, which is particularly important for online monitoring instruments under harsh conditions. Second, for the liquid that has been coarsely filtered, such a pipe diameter can basically avoid the pipe blockage caused by the suspended matter or impurities that may appear in the liquid, ensuring the stability of the flow path. Third, when the catheter is thin enough, its inner diameter will be smaller than the height of the liquid droplet formed inside the catheter due to surface tension and wetting. At this time, the liquid will naturally converge and close the fine channel, and under the drive of the pump, the above liquid can be slowly sent into the target container, thereby avoiding or reducing the amount of liquid that affects the precision in the pipe. If the hole diameter of the catheter is designed to be too large, the liquid that remains on the inner wall of the pipe after passing through the catheter is difficult to be removed by the external blowing gas, because in this case the maximum radial size of the liquid droplet formed by the residual liquid is difficult to reach the height of the inner diameter of the pipe, so even if the gas is introduced, it is also difficult to more thoroughly remove the residual liquid on the inner wall of the pipe due to the existence of the gap, as shown in FIG. 1. In the technical solution of the present application, by selecting the above inner diameter size range of the fine channel, the maximum radial size of the liquid droplet formed by the residual liquid on the inner wall of the pipe can reach or exceed the height of the inner diameter of the pipe (as shown in FIG. 2), so that the residual liquid can be more thoroughly removed by the external blowing gas. Figure 44 Figure 44 ​The fluid (such as liquid or gas) can be used to thoroughly remove the liquid on the inner wall of the pipeline, and the defect that the impurities of the liquid to be monitored in the online monitoring field are easy to block the pipeline in harsh conditions can be avoided.

[0054] It can be understood that, although the use of the fine channel is emphasized in the preferred embodiment of the present application, this does not mean that other non-fine channel devices that can be combined into various complex channel combinations in the present application are excluded, for example, the combination use of a pipeline with a larger inner diameter. Without affecting the purpose of the present application, the fine channel can not be used, but at least a pipeline with a larger inner diameter is used in part, such as a coarse constant volume tube (see Figure 29-32 ) when a constant volume of a conventional volume of more than 2 milliliters is required, and a coarse tube connected to the liquid discharge port of the waste liquid. In this way, the wiring is flexible, the cost is low, and the maintenance is convenient during later use. In addition, although the fine channel is introduced by taking the catheter as an example in the above, it can be understood that the fine channel in the present application is not limited to this form of catheter, but can also be other forms, such as organic multi-way board, micro-fluidic chip groove, etc., as long as the inner diameter size range is met.

[0055] 2. Peristaltic pump

[0056] In the technical solution of the present application, the peristaltic pump is a general definition of a device or device combination with the function of a peristaltic pump. Without special instructions, it refers to a device or device combination that can drive liquid in both forward and reverse directions (sometimes only in one direction) and can be closed to cut off the pipeline when stationary. The above general peristaltic pump includes but is not limited to the following specific devices or device combinations: a narrow-sense peristaltic pump; a series combination of a stop valve and a pump (sometimes only in one direction) or a pump group (for example, a combination of several diaphragm pumps, centrifugal pumps, etc.) that can drive fluid in both forward and reverse directions, etc.

[0057] 3. Stop valve

[0058] In the technical solution of the present application, the stop valve is a general definition of a device or device combination with the function of being able to cut off and close a certain pipeline, including but not limited to the following specific devices: a diaphragm type two-way stop valve; a pinch type two-way stop valve (referred to as a pinch valve); a narrow-sense peristaltic pump (equivalent to closed when stationary, and equivalent to opened when rotating); a rotary switching type two-way or multi-way valve, etc.

[0059] 4. N-to-1 multi-channel valve (where N is a natural number greater than or equal to 2)

[0060] In the technical solution of the present application, the N-to-1 multi-channel valve is a general definition of a device or a combination of devices, which has one common port and N distribution ports, and through a control signal, the common port can be uniquely connected to one of the N distribution ports or all of them are not connected. The above-mentioned general N-to-1 multi-channel valve includes but is not limited to the following specific devices or combinations of devices: a valve group composed of N stop valves connected to the same common port; a multi-channel rotary switching valve (see Figure 35 ); other valve groups composed of multiple stop valves and multiple multi-channel switching valves, etc.

[0061] II. Basic flow path scheme

[0062] As shown in Figures 1A to 1E and Figures 2 to 10 , the present application provides a device (basic flow path scheme) for quantitatively processing liquid, which comprises:

[0063] a container P for containing liquid to be extracted; and

[0064] a through-flow pipeline 10 extending from the inside of the container P to a branching point a;

[0065] a first branch 11 in communication with the through-flow pipeline 10 and extending from the branching point a to a first port K1; and

[0066] a second branch 12 in communication with the through-flow pipeline 10 and extending from the branching point a to a second port K2;

[0067] wherein a peristaltic pump B1 is arranged in series in at least one of the through-flow pipeline 10, the first branch 11 and the second branch 12, and a stop valve F1, F2 or another peristaltic pump B2 is arranged in series in at least one of the through-flow pipeline 10, the first branch 11 and the second branch 12, so as to be able to intercept a predetermined volume of liquid between the branching point a and the first port K1 or the second port K2.

[0068] Preferably, the first branch 11 and / or the second branch 12 is a fine channel (especially when the first branch 11 is used to quantitatively intercept a predetermined volume of liquid, preferably a fine channel; when the second branch is used to quantitatively intercept a predetermined volume of liquid, preferably a fine channel), the fine channel has a pore size of 0.05mm to 5mm, preferably 0.1mm to 3mm, and more preferably 0.5mm to 2mm; further preferably, the throughflow conduit 10 is also a fine channel; or the throughflow conduit 10 is a fine channel within a predetermined length range extending from the branching point a towards the container P, the predetermined length range being at least 0.01mm. By designing the throughflow conduit 10 as a fine channel within a predetermined length range extending from the branching point b1 towards the container P, better reliability and accuracy can be achieved when the first branch 11 and the second branch 12 are used to accurately intercept a predetermined volume of liquid, especially avoiding the situation that at least part of the liquid flows into the throughflow conduit 10 or even backflows into the container P when the liquid flows through the branching point a.

[0069] The container P is used to contain the liquid to be treated or analyzed. The container P can be made of various suitable materials, such as glass or plastic. The capacity of the container P can be selected according to the specific working conditions, and in general the maximum capacity of the container P is 100-2000ml. In addition, the container P can be open, i.e. communicating with the atmosphere, or closed, i.e. not directly communicating with the atmosphere. These two forms will be described in detail in the following embodiments.

[0070] One end of the throughflow conduit 10 is located in the container P and extends outwardly to the branching point a. From the branching point a, the throughflow conduit 10 branches into the first branch 11 and the second branch 12. The first branch 11 has a first port K1, and the second branch 12 has a second port K2.

[0071] It should be noted that the "first" and "second" and the like (such as the first branch and the second branch here) in the present application are only used to distinguish different similar or similar technical features, and do not constitute a substantial limitation on the technical solutions. For example, in different working conditions, a first feature can be exchanged with a second feature, or even first, second, third, etc. can be used to distinguish similar or similar but different technical features or elements, components, parts, etc.

[0072] In order to accurately obtain the liquid sample to be processed or detected, a peristaltic pump B1 is arranged in series in at least one of the through-flow pipeline 10, the first branch 11 and the second branch 12, and a stop valve F1, F2 or another peristaltic pump B2 is arranged in series in at least one of the through-flow pipeline 10, the first branch 11 and the second branch 12, so as to intercept a predetermined volume of liquid between the branch point a and the first port K1 or the second port K2. Specifically, in the three of the through-flow pipeline 10, the first branch 11 and the second branch 12, a peristaltic pump is arranged in series in at least one, and a stop valve or another peristaltic pump is arranged on at least one. The peristaltic pump serves as a power source for pumping or pushing liquid. When the peristaltic pump is rotating, the liquid in the container P can be pumped out, and the liquid after accurate determination can also be pumped out. At the same time, when the peristaltic pump stops rotating, it can also serve as a stop function. Therefore, the cooperation of the peristaltic pump and the stop valve can accurately intercept a predetermined volume of liquid sample between the branch point a and the first port K1 or the second port K2, so as to obtain an accurate liquid sample. In the following, the interception process will be described in detail.

[0073] The technical scheme based on the innovative concept of the present application has many preferred embodiments, mainly in the arrangement and combination of the through-flow pipeline 10, the first branch 11 and the second branch 12, and the peristaltic pump and the stop valve. Specifically, in the three of the through-flow pipeline 10, the first branch 11 and the second branch 12, one of the peristaltic pump, the stop valve and the no-element arrangement (through pipeline) can be selected, so there are 3*3*3=27 combinations in total, and the combination of the three of the through-flow pipeline 10, the first branch 11 and the second branch 12 being all stop valves or all no-element arrangements (because the three being all stop valves or all no-element arrangements is not applicable) needs to be excluded, so there are 25 combinations in total. These combinations are all within the scope of the present application.

[0074] In the following, the structure, connection relationship, operation process and technical advantages of each preferred embodiment will be described with reference to the exemplary illustrations in the drawings.

[0075] Figures 1A to 1E and Figures 2 to 10 Each embodiment of a single device is mainly described. For convenience of description, the present application defines the naming and definition of various basic flow paths. The name is divided into two parts, connected by a “-” sign. For example, “1A-basic type” represents the basic flow path shown in Figure 1A “2-basic type” represents the basic flow path shown in Figure 2 and so on. In addition, since the basic type of Figures 1A to 1E has five variations (all of which have the same principle or are similar), we use “1-basic type” to represent Figures 1A to 1EThe five basic flow paths shown are generally described using the "1A-basic type" as an example.

[0076] Next, the structure and connection of each basic flow path will be described. For the sake of brevity, the description of the basic type in this application only schematically shows part of the basic flow path.

[0077] As shown in Figures 1A to 1E and Figures 2 to 6 , the basic flow path can have various connection forms.

[0078] For example, as shown in Figure 1A and Figure 1B , the first branch 11 is provided with the first peristaltic pump B1 in series, the through-flow line 10 is provided with the first stop valve F1 in series, and the second branch 12 is provided with the second stop valve F2 or the second peristaltic pump B2 in series.

[0079] For example, as shown in Figure 1C and Figure 1D , the first branch 11 is provided with the first peristaltic pump B1 in series, the through-flow line 10 is provided with the third peristaltic pump B3 in series, and the second branch 12 is provided with the second peristaltic pump B2 or the second stop valve F2 in series.

[0080] For example, as shown in Figure 1E , the through-flow line 10 is provided with the third peristaltic pump B3 in series, the first branch 11 is provided with the first stop valve F1 in series, and the second branch 12 is provided with the second peristaltic pump B2 (not shown) or the second stop valve F2 in series.

[0081] For example, as shown in Figure 2 and Figure 3 , the first branch 11 is provided with the first peristaltic pump B1 in series, the through-flow line 10 is a through line, and the second branch 12 is provided with the second stop valve F2 or the second peristaltic pump B2 in series.

[0082] For example, as shown in Figures 4 to 6 , the first branch 11 is a through line, the second branch 12 is provided with the second peristaltic pump B2 or the second stop valve F2 in series, and the through-flow line 10 is provided with the first peristaltic pump B1 in series.

[0083] The basic flow paths shown in Figures 1A to 1E and Figures 2 to 10 will be described in more detail below.

[0084] Implementation Method 1

[0085] As shown in Figures 1A to 1EThe structural composition and connection relationship of the device for quantitatively processing liquid are as follows.

[0086] The container P is used for containing the liquid to be extracted, and is a container in communication with the atmosphere. The throughflow pipeline 10 extends out of the container P (preferably upward) from the inside of the container P and extends to a bifurcation point a. At the bifurcation point a, the throughflow pipeline 10 is bifurcated into a first branch 11 extending from the bifurcation point a to a first port K1 and a second branch 12 extending from the bifurcation point a to a second port K2.

[0087] In each of the throughflow pipeline 10, the first branch 11 and the second branch 12, a peristaltic pump or a stop valve is arranged in series, and at least one of the throughflow pipeline 10, the first branch 11 and the second branch 12 is provided with a peristaltic pump in series. The following is an explanation of several different "1-basic type" flow paths:

[0088] As shown in the "1A-basic type" basic flow path, a first stop valve F1 is arranged in series in the throughflow pipeline 10, a first peristaltic pump B1 is arranged in series in the first branch 11, and a second stop valve F2 is arranged in series in the second branch 12. Figure 1A

[0089] Figure 1A The working process of the embodiment shown is described as follows.

[0090] First, the first stop valve F1 is opened and the second stop valve F2 is kept closed. Then the first peristaltic pump B1 is rotated clockwise (based on the orientation shown in the figure, but not as a limitation of the present application). At this time, the liquid in the container P enters the throughflow pipeline 10 under the extraction of the first peristaltic pump B1, passes through the first stop valve F1 and the first peristaltic pump B1, and then overflows through the first port K1.

[0091] Then, the first stop valve F1 is closed, the second stop valve F2 is opened, and the first peristaltic pump B1 is rotated counterclockwise. At this time, air enters from the first port K1, so that the liquid in the volume of the pipe between the bifurcation point a and the first port K1 is taken out from the K2 port. Alternatively, the first peristaltic pump B1 is rotated clockwise, so that air enters from the second port K2, and the liquid in the volume of the pipe between the bifurcation point a and the first port K1 is taken out from the first port K1.

[0092] As shown in the "1B-basic type" basic flow path, a first stop valve F1 is arranged in series in the throughflow pipeline 10, a first peristaltic pump B1 is arranged in series in the first branch 11, and a second stop valve F2 is arranged in series in the second branch 12. Figure 1B Figure 1A ​​The main difference between the "1A-base" basic flow path shown in FIG. 1A and the "1A-base" basic flow path shown in FIG. 1B is that the second stop valve F2 is replaced by the second peristaltic pump B2. Thus, when the second peristaltic pump B2 is stationary, it can function as a stop valve. The liquid feeding operation process using the "1A-base" flow path can measure and fix the volume of liquid in the first branch pipe or the second branch pipe. When it is necessary to take out the liquid with the volume of the pipe between the bifurcation point a and the first port K1 or the second port K2 fixed, the first peristaltic pump B1 and the second peristaltic pump B2 can be made to rotate in the same direction but at different speeds, so as to take out the liquid from the first port K1 or the second port K2. In this scheme, the devices on the first branch 11 and the second branch 12 are preferably designed to be interchangeable, but can also be different peristaltic pumps.

[0093] As shown in FIG. 1C, the "1C-base" basic flow path is different from the "1A-base" basic flow path shown in FIG. 1A in that the first stop valve F1 is replaced by the third peristaltic pump B3. Thus, when the third peristaltic pump B3 is stationary, it can function as a stop valve. The liquid feeding operation process using the "1A-base" flow path can measure and fix the volume of liquid in the first branch pipe or the second branch pipe. When it is necessary to take out the liquid with the volume of the pipe between the bifurcation point a and the first port K1 or the second port K2 fixed, the first peristaltic pump B1 and the third peristaltic pump B3 can be made to rotate in the same direction but at different speeds, so as to take out the liquid from the first port K1 or the second port K2. Figure 1C Figure 1A As shown in FIG. 1D, the "1D-base" basic flow path is different from the "1A-base" basic flow path shown in FIG. 1A in that the first stop valve F1 and the second stop valve F2 are replaced by the third peristaltic pump B3 and the second peristaltic pump B2, respectively. Thus, when the second peristaltic pump B2 or the third peristaltic pump B3 is stationary, it can function as a stop valve. The liquid feeding operation process using the "1A-base" flow path can measure and fix the volume of liquid in the first branch pipe or the second branch pipe. When it is necessary to take out the liquid with the volume of the pipe between the bifurcation point a and the first port K1 or the second port K2 fixed, the first peristaltic pump B1 and the second peristaltic pump B2 can be made to rotate in the same direction but at different speeds, so as to take out the liquid from the first port K1 or the second port K2.

[0094] As shown in FIG. 1E, the "1E-base" basic flow path is different from the "1A-base" basic flow path shown in FIG. 1A in that the third peristaltic pump B3 is arranged in series in the through-flow pipe 10, the first stop valve F1 is arranged in series in the first branch 11, and the second stop valve F2 is arranged in series in the second branch 12. Figure 1D Figure 1A As shown in FIG. 1D, the "1D-base" basic flow path is different from the "1A-base" basic flow path shown in FIG. 1A in that the first stop valve F1 and the second stop valve F2 are replaced by the third peristaltic pump B3 and the second peristaltic pump B2, respectively. Thus, when the second peristaltic pump B2 or the third peristaltic pump B3 is stationary, it can function as a stop valve. The liquid feeding operation process using the "1A-base" flow path can measure and fix the volume of liquid in the first branch pipe or the second branch pipe. When it is necessary to take out the liquid with the volume of the pipe between the bifurcation point a and the first port K1 or the second port K2 fixed, the first peristaltic pump B1 and the second peristaltic pump B2 can be made to rotate in the same direction but at different speeds, so as to take out the liquid from the first port K1 or the second port K2.

[0095] As shown in FIG. 1E, the "1E-base" basic flow path is different from the "1A-base" basic flow path shown in FIG. 1A in that the third peristaltic pump B3 is arranged in series in the through-flow pipe 10, the first stop valve F1 is arranged in series in the first branch 11, and the second stop valve F2 is arranged in series in the second branch 12. Figure 1E

[0096] Figure 1E The working process of the embodiment shown in FIG. 1E is described as follows. ​​​

[0097] First, open the first stop valve F1 and keep the second stop valve F2 closed. Then rotate the third peristaltic pump B3 counterclockwise (in the orientation shown in the figure, but not as a limitation to the present application). At this time, the liquid in the container P enters the through-flow line 10 under the extraction of the third peristaltic pump B3, passes through the third peristaltic pump B3 and the first stop valve F1, and is then discharged through the first port K1.

[0098] Then, open the first stop valve F1, keep the first peristaltic pump B1 stationary, and open the second stop valve F2. At this time, air enters from the first port K1, and the volume of the liquid in the section of the tube between the bifurcation point a and the first port K1 is discharged from the second port K2 under the action of gravity. Similarly, due to the preferred design of the fine channel, when the third peristaltic pump B3 is kept stationary and the second stop valve F2 is closed, the volume of the liquid in the section of the tube between the bifurcation point a and the first port K1 will not flow downward by itself, but will flow out by itself under the action of gravity when the second stop valve F2 is opened.

[0099] As can be seen from the above description, since the peristaltic pump has two rotational working conditions, it can be used to both extract the liquid in the container P and discharge the liquid from the corresponding port. The basic flow path of each type in Figure 1 is characterized in that: in the through-flow line, the first branch and the second branch, at least one peristaltic pump or stop valve must be connected in series in each branch, and one peristaltic pump must be connected in series in one branch.

[0100] According to the embodiment shown in Figures 1A to 1E , the extraction of a predetermined volume of liquid sample can be achieved with high work efficiency, and the accuracy of the volume of the obtained liquid sample is relatively high. Moreover, since the inner diameter of the fine channel is small under the preferred condition, the volume of the intercepted liquid sample is also relatively small. By adjusting the lengths of the first branch 11 and the second branch 12, the size of the liquid volume to be intercepted can be determined, and this method is also applicable in other implementation cases below.

[0101] Implementation Method 2

[0102] As shown in Figure 2 , the basic flow path structure and connection relationship of the device for quantitatively processing liquid are as follows.

[0103] The container P is used to contain the liquid to be extracted, and the container P is an open container. The through-flow line 10 extends outward from the inside of the container P (preferably upward) and extends to the bifurcation point a. At the bifurcation point a, the through-flow line 10 is divided into the first branch 11 and the second branch 12, the first branch 11 extends from the bifurcation point a to the first port K1, and the second branch 12 extends from the bifurcation point a to the second port K2.

[0104] As shown in the figure, no component is arranged in series in the through-flow pipeline 10, a first peristaltic pump B1 is arranged in series in the first branch 11, and a second stop valve F2 is arranged in series in the second branch 12. Figure 2

[0105] Figure 2 The working process of the embodiment shown is described as follows.

[0106] First, the second stop valve F2 is kept closed, and then the first peristaltic pump B1 is rotated clockwise (in the orientation shown in the figure, but not as a limitation to the present application). At this time, the liquid in the container P enters the through-flow pipeline 10 under the extraction of the first peristaltic pump B1, passes through the first peristaltic pump B1, and then overflows through the first port K1.

[0107] Then, the first peristaltic pump B1 is kept stationary (equivalent to a stop state), and the second stop valve F2 is opened. At this time, air enters from the second port K2, so that the liquid between the bifurcation point a and the container P flows back to the container P under the action of gravity, and the volume-constant liquid in the section of the pipeline between the bifurcation point a and the first port K1 remains stationary due to the stop of the peristaltic pump B1 and the surface tension and inextensibility of the liquid.

[0108] Subsequently, the first peristaltic pump B1 is rotated clockwise, so that air enters from the second port K2 due to the fact that the resistance of air entering from the second port K2 is much smaller than the gravity to be overcome when the liquid in the container P rises, and then the volume-constant liquid in the section of the pipeline between the bifurcation point a and the first port K1 is taken out from the first port K1.

[0109] As can be seen from the above description, by using the inner diameter characteristics of the fine channel, in combination with the physical effects of gravity, inextensibility and surface tension of the liquid, the technical solution of the present application can be realized at a relatively low cost.

[0110] Implementation Method 3

[0111] As shown in the preferred embodiment three, the main difference from the embodiment two shown in the figure is that the second stop valve F2 is replaced by a second peristaltic pump B2. Therefore, when the second peristaltic pump B2 is stationary, it can play a stop role. When the volume-constant liquid in the section of the pipeline between the bifurcation point a and the first port K1 needs to be taken out, the first peristaltic pump B1 and the second peristaltic pump B2 are made to rotate in the same direction but at different speeds, so that the above-mentioned liquid is taken out from the first port K1 or the second port K2. Figure 3 Figure 2

[0112] Implementation Method 4

[0113] As​​​ Figure 4 The structure and connection of the device for quantitatively processing liquid are as follows.

[0114] The container P is used for containing liquid to be extracted, and the container P is an atmosphere-communicating container. The throughflow pipeline 10 extends from the inside of the container P to the outside of the container P (preferably upward) and extends to a bifurcation point a. At the bifurcation point a, the throughflow pipeline 10 is bifurcated into a first branch 11 extending from the bifurcation point a to a first port K1 and a second branch 12 extending from the bifurcation point a to a second port K2.

[0115] As shown in the figure, a first peristaltic pump B1 is arranged in series in the throughflow pipeline 10, no device is arranged in series in the first branch 11, and a second peristaltic pump B2 is arranged in series in the second branch 12. Figure 4

[0116] Figure 4 The working process of the embodiment is described as follows.

[0117] First, the second peristaltic pump B2 is kept static, and then the first peristaltic pump B1 is rotated counterclockwise (based on the orientation shown in the figure, but not as a limitation of the present application). At this time, the liquid in the container P enters the throughflow pipeline 10 under the extraction of the first peristaltic pump B1, passes through the first peristaltic pump B1 and the intersection point a, and then overflows through the first port K1.

[0118] Then, the first peristaltic pump B1 is kept static (equivalent to a cut-off state), and the second peristaltic pump B2 is rotated counterclockwise. At this time, air enters from the first port K1, so that the volume-determined liquid in the pipe between the bifurcation point a and the first port K1 is taken out from the second port K2. Alternatively, the second peristaltic pump B2 is rotated clockwise, so that air enters from the second port K2, so that the volume-determined liquid in the pipe between the bifurcation point a and the first port K1 is taken out from the first port K1.

[0119] As described above, the static cut-off working condition and the bidirectional rotation working condition of the two peristaltic pumps can be used to cut off the predetermined liquid sample from the first port K1 or the second port K2 as needed.

[0120] Implementation Method 5 and Implementation Method 6

[0121] As shown in the figure, the structure and connection of the device for quantitatively processing liquid are as follows. Figure 5 Figure 6 The structure and connection of the device for quantitatively processing liquid are as follows.

[0122] The container P is used for containing liquid to be extracted, and the container P is an atmosphere-communicating container.

[0123] ​​The flow passage 10 extends outward from the inside of container P (preferably upward) and extends to the bifurcation point a.

[0124] At the bifurcation point a, the flow path 10 splits into a first branch 11 and a second branch 12. The first branch 11 extends from the bifurcation point a to the first port K1, and the second branch 12 extends from the bifurcation point a to the second port K2. The first branch 11 is a pipe that extends obliquely from the bifurcation point a to the first port K1, either upwards or downwards. The angle of inclination of this oblique pipe relative to the horizontal plane can be selected according to the specific application conditions, such as between 30 degrees and 90 degrees, or preferably around 45 degrees.

[0125] like Figure 5 and Figure 6 As shown, a first peristaltic pump B1 is connected in series in the flow path 10, no components are connected in series in the first branch 11, and a second shut-off valve F2 is connected in series in the second branch 12.

[0126] Figure 5 and Figure 6 The working process of the illustrated embodiment is as follows.

[0127] First, keep the second shut-off valve F2 closed. Then, rotate the first peristaltic pump B1 counterclockwise (based on the orientation shown in the figure, but not as a limitation of this application). At this time, the liquid in container P enters the flow passage 10 under the pumping of the first peristaltic pump B1, passes through the first peristaltic pump B1 and the bifurcation point a, and then overflows through the first port K1.

[0128] Then, in Figure 5 In the illustrated operating condition, the first peristaltic pump B1 remains stationary, and the second shut-off valve F2 is open. At this time, air enters through the second port K2, while a section of pipe between the bifurcation point a and the first port K1, containing a constant volume of liquid, flows out from the first port K1 under gravity. In this scenario, due to the preferred narrow-channel design, when the first peristaltic pump B1 remains stationary and the second shut-off valve F2 is closed, the constant-volume liquid in the section of pipe between the bifurcation point a and the first port K1 will not flow downwards on its own. Instead, it will flow out under gravity only after the second shut-off valve F2 is opened.

[0129] And in Figure 6In the shown working condition, the first peristaltic pump B1 remains static, and the second stop valve F2 is opened. At this time, air enters from the first port K1, and the volume of the liquid in the section of the tube between the bifurcation point a and the first port K1 is constant, and the liquid flows out from the second port K2 under the action of gravity. Similarly, due to the design of the fine channel, when the first peristaltic pump B1 remains static and the second stop valve F2 is closed, the volume of the liquid in the section of the tube between the bifurcation point a and the first port K1 is constant, and the liquid does not flow downward by itself, but flows out by itself under the action of gravity when the second stop valve F2 is opened.

[0130] As can be seen from the above description, by simply using the static stop function of the peristaltic pump and the inclined design of the branch, and preferably using the design of the fine channel, the liquid sample of accurate volume can be conveniently intercepted and collected by using gravity.

[0131] The above various embodiments do not exhaust various combination relationships under the technical solutions of the present application. For example, in different embodiments, when no flow path device is provided, the branch and the through-flow pipe can be formed in the form of a through pipe. In some of the above embodiments, the through-flow pipe 10 can be designed as a through pipe; and in other embodiments, the first branch 11 and / or the second branch can be designed as a through pipe. The working process of the embodiments not shown in the drawings of the specification of the present application can be naturally referred to the detailed description of the structures and working processes of the above various embodiments.

[0132] In the above various embodiments, the container P is an open container communicating with the atmosphere. However, in some working conditions requiring harsh requirements for strong corrosive reagents, volatile reagents or water samples, the container P is designed as a closed container not directly communicating with the atmosphere, such as Figures 7 to 10 The closed container can be obtained by first injecting liquid into the container and then sealing it. The closed container is connected with a pressurizing device for increasing the gas pressure in the container, and the through-flow pipe 10 extends out of the container P from the inside of the container P. The details will be described below. Figures 7 to 10

[0133] Implementation Method Seven

[0134] As shown in Figure 7 The structure and connection relationship of the device for quantitatively processing liquid are as follows.

[0135] The container P is used to contain the liquid to be extracted, and the container P is a closed container not directly communicating with the atmosphere.

[0136] ​The flow path 10 extends outward from the container P (preferably upward) and extends to a branch point a. At the branch point a, the flow path 10 splits into a first branch 11 and a second branch 12. The first branch 11 extends from the branch point a to a first port K1, and the second branch 12 extends from the branch point a to a second port K2.

[0137] like Figure 7 As shown, a first shut-off valve F1 is connected in series in the flow path 10, a second shut-off valve F2 is connected in series in the first branch 11, and a third peristaltic pump B3 is connected in series in the second branch 12.

[0138] Figure 7 The working process of the illustrated embodiment is as follows.

[0139] First, the first shut-off valve F1 opens, and the second shut-off valve F2 closes. The third peristaltic pump B3 rotates clockwise, causing air to enter the container P from the second port K2 through the first shut-off valve F1, where it is pressurized. Therefore, the third peristaltic pump B3 acts as a pressurizing device at this time.

[0140] Then, first close the first shut-off valve F1 and keep the third peristaltic pump B3 stationary (shut down). Then open the first shut-off valve F1 and the second shut-off valve F2. At this time, the liquid in the container P will enter the flow passage 10 under the action of internal pressure, and then overflow through the first port K1 after passing through the first shut-off valve F1 and the second shut-off valve F2.

[0141] Then, the first shut-off valve F1 is closed, and the third peristaltic pump B3 is rotated clockwise. Air then enters from the second port K2, pushing out the liquid at the first port K1, which has a constant volume, from the section of pipe between the bifurcation point a and the first port k1. Alternatively, the third peristaltic pump B3 is rotated counterclockwise, and air then enters from the first port K1, pushing out the liquid at the second port K2, which has a constant volume, from the section of pipe between the bifurcation point a and the first port k1.

[0142] Implementation Method Eight

[0143] like Figure 8 As shown, the structure and connection relationship of the device for quantitative liquid processing are as follows.

[0144] Container P is used to contain the liquid to be extracted, and container P is a closed container that is not directly connected to the atmosphere. The pressurizing device is a heater 30 installed inside the container, which is used to heat the air inside the container.

[0145] The throughflow conduit 10 extends from the inside of the container P to the outside of the container P (preferably upwardly) and extends to a branching point a. At the branching point a, the throughflow conduit 10 branches into a first branch 11 extending from the branching point a to a first port K1 and a second branch 12 extending from the branching point a to a second port K2.

[0146] As shown in Figure 8 , a first shut-off valve F1 is arranged in series in the throughflow conduit 10, no component is arranged in series in the first branch 11, and a third peristaltic pump B3 is arranged in series in the second branch 12.

[0147] Figure 8 The working process of the embodiment shown is described as follows.

[0148] First, the first shut-off valve F1 is opened, and the third peristaltic pump B3 is at rest. The heater 30 heats the air in the container P to pressurize. At this time, the liquid in the container P will enter the throughflow conduit 10 under the action of the internal pressure, and then pass through the first shut-off valve F1 and the branching point a to overflow through the first port K1.

[0149] Subsequently, the first shut-off valve F1 is closed again, and the third peristaltic pump B3 is rotated clockwise, so that the air enters from the second port K2 to push the liquid in the volume of the section of the pipe between the branching point a and the first port K1 out of the first port K1. Alternatively, the third peristaltic pump B3 is rotated counterclockwise, so that the air enters from the first port K1 to push the liquid in the volume of the section of the pipe between the branching point a and the first port K1 out of the second port K2.

[0150] In this embodiment, a cooler is preferably arranged. After the liquid sample of the predetermined volume is cut off, the air in the container P can be cooled to make the liquid between the branching point a and the port 101 of the throughflow conduit 10 flow back into the container P, thereby facilitating the next liquid taking operation.

[0151] Implementation methods nine and ten

[0152] Referring to Figure 9 and Figure 10 , the main difference between the ninth embodiment and the eighth embodiment shown in Figure 8 lies in the pressurizing device.

[0153] In the tenth embodiment, as shown in Figure 10 , the pressurizing device comprises a fourth peristaltic pump B4, and the liquid container P is directly communicated with the outside atmosphere through the fourth peristaltic pump B4. In the ninth embodiment, as shown in Figure 9As shown, the fourth peristaltic pump B4 can be connected with another auxiliary container P2 (containing the same liquid) which is in communication with the atmosphere, to pressurize the liquid in the auxiliary container P2 into the container P.

[0154] The working process of other embodiments of intercepting a predetermined volume of liquid sample can refer to embodiment eight.

[0155] The above embodiments do not exhaust all the combination relationships under the technical solutions of the present application. For example, a peristaltic pump can also be connected in series in the through-flow pipeline 10, and a peristaltic pump or a stop valve can be connected in series in the second branch or the first branch, and the peristaltic pump works with the stop valve and the pressurizing device to make the liquid sample of a predetermined volume between the branch point a and the first port K1 flow out of the first port K1 or the second port K2.

[0156] The above describes the embodiments of the closed container, and each of the above embodiments can be selected according to the specific working conditions.

[0157] In addition, as shown, in a preferred case, the first branch 11 is provided with a liquid detector S at a position adjacent to the first port K1, and the liquid of a predetermined volume between the branch point a and the first port K1 is the liquid between the branch point a and the liquid detector S. The liquid detector S can be various sensors suitable for determining whether there is liquid, to determine whether there is liquid or the liquid reaches the position where the liquid detector S is located.

[0158] By providing the liquid detector S, it is not necessary to determine the volume capacity by making the liquid flow out of the first port K1. That is, in the embodiment provided with the liquid detector S, the liquid sample of a more flexible volume end near the branch point a to the liquid detector S can be intercepted. At the same time, since there is no overflow of liquid, waste can be prevented. Further preferably, the liquid between the branch point a and the liquid detector S is the liquid from the branch point a to a predetermined offset point based on the liquid detector S, and the distance of the predetermined offset point can be controlled by the liquid flow algorithm (for example, related to the flow speed of the liquid, or related to whether the liquid contains bubbles, or related to the length and volume of the bubbles), so as to realize error compensation for various uncertain factors (bubbles, liquid flow speed, pulsation error of peristaltic pump liquid when flowing in, etc.) when flowing in, to obtain a more accurate liquid sample of a predetermined volume. It can be understood that in the technical solutions of the present application, a liquid detector S can also be provided at a position adjacent to the second port K2 of the second branch 12. It can be understood that the technical features of the liquid detector S can be applied to various basic flow paths in the present application, and are not limited to the embodiments shown in the drawings of the present application.

[0159] In a preferred embodiment, the first port K1 is provided with a downwardly extending extension section (not shown), preferably extending vertically downward, to ensure that when the liquid overflows from the outlet, the interference of uncertain factors on the quantitative interception of volume is avoided, and the accuracy of volume determination is further improved.

[0160] Figures 1A to 1E as well as Figures 2 to 10 The various implementations of the basic flow path are described in detail. According to further preferred embodiments, individual basic flow paths can be appropriately arranged and combined to suit applications where multiple containers P contain the same or different liquids. The combined apparatus schemes formed by combining individual basic flow paths are described in detail below.

[0161] In addition, it is understandable that the main advantage of the above-mentioned basic flow path over traditional technology under preferred conditions is that the flow path scheme of combining a fine channel with a peristaltic pump and / or a shut-off valve under preferred conditions can achieve high-precision volume control and delivery, and has high working efficiency, very low cost and can be flexibly combined (series, serial or parallel).

[0162] III. Combined Flow Path Scheme

[0163] As described above, each basic flow path includes five elements: a first port K1, a second port K2, a first branch 11, a second branch 12, and a bifurcation point a. Depending on different operating conditions and liquid inlet requirements, these various types of basic flow paths can be combined in different ways to obtain different combined flow path schemes.

[0164] For ease of explanation, this application specifies the naming definitions for various access methods of basic flow paths to main and branch lines. The name consists of three parts connected by a "-" sign, such as "1-K1-B". The specific naming definitions are as follows:

[0165] The first part, the name, indicates the basic flow path used, such as... Figures 1A to 1E If one of the basic flow paths is used, then that part is named "1". Figure 2 If the basic flow path is defined as "2", then this part is named "2", and so on. It should be noted that since there are five variations of the basic flow path in Figure 1, but the principle is the same, we use the "1A-basic type" flow path as an example. In combined flow paths, we generally use "1" for unified naming unless otherwise specified.

[0166] The second part of the name identifies the connection point between the basic flow path and the main branch. For example, if the connection point is the first port K1, the name of this part is "K1"; if the connection point is the second port K2, the name of this part is "K2"; if the connection point is a branch point a, the name of this part is "a". And so on.

[0167] The third part identifies how each type of basic flow path is merged into the main branch. The different merging methods are defined as follows:

[0168] Type A indicates that each basic flow path is independent and connected to the main branch in parallel, and is identified as "A", such as... Figure 11A and Figure 11B As shown, Figure 11C The example only illustrates one basic flow path, but it is understood that multiple basic flow paths can be connected in parallel.

[0169] Type P indicates that each type of combined flow path is independent and connected in parallel to the main branch, but a peristaltic pump B needs to be installed on the main branch to better drive fluid metering and liquid inlet. This type of combined flow path is identified as "P". Figure 12 As shown;

[0170] Type B indicates that the first branch 11 of the basic flow path of the same or different types is combined and shared, and then connected to the main branch through the first port K1 or the second port K2. This type of combined flow path is identified as "B". Figures 13A to 13D As shown;

[0171] Type C indicates that the second branch 12 of the basic flow path of the same or different types is combined and shared, and then connected to the main branch through the first port K1 or the second port K2. This type of combined flow path is identified as "C", such as Figures 14A to 14C As shown;

[0172] Type BC indicates that the first branch 11 of the same or different basic flow paths is combined and shared, and the second branch 12 is also combined and shared. It then connects to the main branch through the first port K1 or the second port K2. This type of combined flow path is identified as "BC". Figures 15A to 15D As shown;

[0173] Type H indicates that the intersection point 'a' of various basic flow paths is combined and shared, and the main branch is directly connected through point 'a'. A peristaltic pump or shut-off valve is connected in series on the main branch; or, one or more of the first or second branches in the basic flow path are directly used as the main branch; this type of combined flow path is identified as "H", as shown in Figure 16.

[0174] It should be noted that the designations such as A, B, C, BC, P, and H are only used to distinguish different flow path schemes and do not constitute a limitation on the scope of protection of this application. The above-mentioned flow path scheme naming method also applies to the flow path schemes shown in other figures of this application.

[0175] It should be noted that in all types of combined flow paths, the intersection a can be a point or a section of the flow path in physical existence. In order to more conveniently and concisely display the topology of the combined flow paths connecting to the trunk branch, the trunk and branch of each figure are divided and displayed in three rows, and it should be noted that the trunk and branch can also be formed by a continuous trunk branch according to the needs.

[0176] Next, the structure and connection relationship of each type of combined flow path will be described. For the sake of simplicity, only one or two basic flow paths are schematically shown in some combined flow paths, and it should be noted that more basic flow paths can be designed in application. In addition, in the combined flow path scheme, the trunk branch can be one or more. These variations are within the scope of protection of the present application.

[0177] 3.1A type combined flow path:

[0178] The definition of A-type combined flow path is that each basic flow path is independent of each other and is connected to a higher level trunk branch through the first port K1 or the second port K2, thereby forming a combined flow path that can parallelly flow (or can be used for liquid discharge). One port of the trunk branch is closed, and the other port is used as the common outlet for transporting liquid of each basic flow path, as shown in Figures 11A to 11C .

[0179] Figures 11A-11C The partial combined forms of using the basic flow paths shown in FIGS. 1 to Figure 6 are connected in parallel to the same trunk branch are listed in Table 2.

[0180] For example, "1-K1-A type" means that the basic flow path in FIG. 1 is connected to the trunk branch through the first port K1, "1-K2-A type" means that the basic flow path in FIG. 1 is connected to the trunk branch through the second port K2, "2-K1-A type" means that the basic flow path in FIG. 2 is connected to the trunk branch through the first port K1, and so on. Figure 2

[0181] For example, as shown in Figures 11A to 11C , the first port K1 of the basic flow path shown in Figures 1A to 1E , the second port K2 of the basic flow path shown in Figures 1A to 1E , and the first port K1 of the basic flow path shown in Figure 2 can be independently connected to the same trunk flow path; or the first port K1 (or the second port K2) of the basic flow path shown in Figure 3 , the first port K1 of the basic flow path shown in Figure 4 , and the second port K2 of the basic flow path shown in Figure 4 can be connected to the same trunk flow path; or other options can also be selected.​ Figure 6 The second port K2 of the basic flow path shown and the first port or the second port (not shown) of other basic flow paths are connected into the same trunk flow path. The above-mentioned basic flow paths can be independently filled with liquid according to the aforementioned metering filling step.

[0182] Meanwhile, the liquid detector S is installed on the branch pipe connected to the trunk branch in the "1-K1-A type", "2-K1-A type", "3-K1-A type", "3-K2-A type", "4-K1-A type", and "6-K2-A type", which is used for metering positioning or detecting whether the liquid reaches the detection position, so as to ensure that the liquid does not enter the trunk branch according to the working condition during metering.

[0183] It can be understood that the combination flow path scheme shown in Figures 11A to 11C is only a part of all possibilities of the arrangement combination of the basic flow paths shown in Figures 1A to 1E and Figures 2 to 6 The protection scope of the present application covers all forms of arrangement combination. For example, N basic flow paths can be connected into the same trunk flow path, N is a natural number greater than or equal to 1, and each basic flow path can select the first port K1 or the second port K2 to connect into the same trunk flow path. It can also be understood that the basic flow path is not limited to the basic flow path scheme shown in Figure 6 , but can also select the basic flow path scheme shown in Figures 7 to 10 .

[0184] It can be understood that, as mentioned above, although the present application emphasizes the use of fine channels, this does not mean that other non-fine channel devices that can be combined into various complex combination channels in the present application are excluded. Without affecting the purpose of achieving the present application, the fine channel can not be used, but at least in part, a pipe with a larger inner diameter is used, such as Figure 11C When a conventional volume of more than, for example, 2 milliliters needs to be volumed, the first branch 11 of the "6-K2-A type" can use a coarse voluming pipe to increase the liquid filling or discharge speed, thereby improving the overall processing or detection speed of the device.

[0185] The beneficial effect of the A-type combination flow path is that the water samples or reagents connected by each basic flow path can be filled and metered at the same time, which can greatly improve the overall processing efficiency or detection speed of the device.

[0186] 3.2P type combined flow path

[0187] Preferably, in order to more conveniently realize the flow of liquid, at least one peristaltic pump B can be arranged on the trunk flow path of the A-type combination flow path, as shown in Figure 12 This type of combination flow path is named "P-type combination flow path" by the present application

[0188] Figure 12 Two combined flow paths of "5-K2-P type" and "6-K2-P type" are listed. Due to the peristaltic pump B in the trunk flow path, the fluid in the basic flow path can not only flow by gravity or other pump driving, but also better realize the movement control of the liquid by using the peristaltic pump B in the trunk flow path. It can be understood that, Figure 12 Only for example, other basic flow paths with different numbers can also be selected, and each basic flow path can select its own first port K1 or second port K2 to access the same trunk flow path. At this time, the peristaltic pump B in the P-type trunk flow path needs to work with the respective peristaltic pumps and stop valves in the basic flow path, so as to better transport the liquid in the flow path according to the set requirements.

[0189] 3.3B type combined flow path:

[0190] The definition of B-type combined flow path is that the first branch 11 of the same type basic flow path is merged and shared, and then accessed to a higher level trunk flow branch through the first port K1 or the second port K2 (K2') respectively, thereby forming a combined flow path that can parallelly progress liquid (which can also be used for liquid discharge). One port of the trunk flow branch is closed, and the other port is used as the common outlet of each B-type combined flow path, as shown in Figures 13A to 13D .

[0191] Figures 13A to 13D The combined forms of each basic flow path shown in Figures 1A to 1E and Figures 2 to 6 are combined according to the above rules, and then connected in parallel to the same trunk flow branch through the first port K1 or the second port K2.

[0192] As "1-K1-B type" means the basic flow path in Figures 1A-1E , the first branch 11 of which is merged and shared, and then accessed to the trunk flow branch through the first port K1; "1-K2-B type" means the basic flow path in Figures 1A-1E , the first branch 11 of which is merged and shared, and then accessed to the trunk flow branch through the second port K2; "4-K1-B type" means the basic flow path in Figure 4 , the first branch 11 of which is merged and shared, and then accessed to the trunk flow branch through the first port K1; "4-K2-B type" means the basic flow path in Figure 4 , the first branch 11 of which is merged and shared, and then accessed to the trunk flow branch through the second port K2; "6-K2-B type" means the basic flow path in Figure 6 , the first branch 11 of which is merged and shared, and then accessed to the trunk flow branch through the second port K2; and so on.

[0193] Each of the above basic flow paths can be fed liquid according to its aforementioned metering and feeding principle and steps. However, when one of the flow paths is working, except for the devices on the first branch 11 that works together, the devices on the other basic flow paths should be in a stationary state (peristaltic pump stationary, shut-off valve closed). This will not be elaborated further here.

[0194] In a preferred embodiment, each type B combined flow path may be equipped with a liquid detector S on the branch pipe connected to the main flow branch for metering positioning or to detect whether the liquid has reached the detection position, so as to ensure that the liquid does not enter the main flow branch during metering according to the working conditions (in some cases, the main flow branch can also be regarded as the extension of the first branch or the second branch (applicable to all embodiments of this application)).

[0195] Understandably, in Figures 13A to 13D The combined flow path schemes shown are only some of the implementation methods formed by combining the basic flow paths shown in the illustrations according to the type B combined flow path scheme. It is to be understood that this application is not limited to this, and the scope of protection of this application covers all permutations and combinations of various basic flow paths. For example, the basic flow paths used to implement the combined flow path are not limited to... Figures 1A-1E and Figures 2 to 6 The basic flow path scheme shown can also be selected Figures 7 to 10 The basic flow path scheme shown can also be selected if it is not shown in the diagram.

[0196] Compared to the combined flow paths of type A and type P, the beneficial effect of the combined flow path of type B is that it reduces the number of peristaltic pumps or shut-off valves, thereby saving costs and improving stability.

[0197] 3.4C type combined flow path:

[0198] The definition of a type C combined flow path is as follows: Second branches 12 of the same type of basic flow path are merged and shared, and then connected to a higher-level main branch through either an independent first port K1 (K1') or a shared second port K2, thus forming a combined flow path that can be used for liquid inlet (and outlet). One port of this main branch is closed, and the other port serves as a common outlet for the liquid transported by each type C combined flow path, such as... Figures 14A to 14C As shown.

[0199] Figures 14A to 14C The list of uses Figures 1A-1E and Figures 2 to 6 The various basic flow paths shown are combined and combined according to the above rules, and then connected in parallel to the same main branch through the first port K1 or the second port K2.

[0200] For example, "1-K1-C type" means the basic flow path in Figure 1, where the second branch 12 is merged and shared, and then connected to the main branch through the first port K1; "1-K2-C type" refers to... Figure 1A the second branch 12 of the basic flow path merges into the common flow path, and then accesses the main flow branch through the second port K2; "4-K2-C type" means that the second branch 12 of the basic flow path merges into the common flow path, and then accesses the main flow branch through the first port K2; and so on. Figure 4 the second branch 12 of the basic flow path merges into the common flow path, and then accesses the main flow branch through the second port K2; "4-K2-C type" means that the second branch 12 of the basic flow path merges into the common flow path, and then accesses the main flow branch through the first port K2; and so on.

[0201] The above-mentioned basic flow paths can all access liquid according to the aforementioned metering liquid principle and steps. When one of the through flow paths is working, the devices on the other basic flow paths should be in a static state (peristaltic pump is static, and the stop valve is closed) except for the devices on the first branch 11 which work together. This will not be repeated here.

[0202] At the same time, the liquid detector S can be installed on the branch pipe connected with the main flow branch of each C-type combined flow path for metering positioning or detecting whether the liquid reaches the detection position to ensure that the liquid does not enter the main flow branch during metering according to the working condition.

[0203] It can be understood that the combined flow path scheme shown in Figures 14A to 14C is only a part of the most practical and feasible flow path formed by combining the basic flow paths shown in Figures 1A-1E and Figures 2 to 6 The protection scope of the present application covers all permutations and combinations. For example, the basic flow paths used to realize the combined flow path are not limited to the basic flow path schemes shown in Figures 1A-1E and Figures 2 to 6 The basic flow path scheme shown in Figures 7 to 10 can also be selected. The basic flow path scheme not shown in the figure can also be selected.

[0204] It should be noted that the 1-K1-C type combined flow path has two or more access points: K1 and K1', which can be different positions of the same main flow branch (as shown in Figures 14A to 14C ), or can be distributed to access different main flow branches (not shown).

[0205] Compared with the A-type and P-type combined flow paths, the C-type combined flow path has the beneficial effect of reducing the number of peristaltic pumps or stop valves, thereby saving costs and improving stability.

[0206] 3.5BC type combined flow path:

[0207] The definition of BC type combined flow path is that the first branch 11 and the second branch 12 of the same type basic flow path are respectively combined and shared, and then access to a higher level dry flow branch through the combined shared first port K1 or the combined shared second port K2, thereby forming a combined flow path which can respectively enter liquid (also can be used for liquid discharge). Figures 15A to 15D

[0208] Figures 15A to 15D The combination forms of each basic flow path shown in Figures 1A-1E and Figures 2 to 6 are combined according to the above rules, and then connected in parallel to the same dry flow branch through the first port K1 or the second port K2.

[0209] As "1-K1-BC type" means that one of the basic flow paths in Figures 1A-1E , the first branch 11 and the second branch 12 are respectively combined and shared, and then access to the dry flow branch through the first port K1; "1-K2-BC type" refers to the basic flow path in Figure 4 , the first branch 11 and the second branch 12 are respectively combined and shared, and then access to the dry flow branch through the second port K2; "4-K1-BC type" means that the basic flow path in Figure 4 , the first branch 11 and the second branch 12 are respectively combined and shared, and then access to the dry flow branch through the first port K1; "4-K2-BC type" refers to the basic flow path in Figure 6 , the first branch 11 and the second branch 12 are respectively combined and shared, and then access to the dry flow branch through the second port K2; "6-K2-BC type" refers to the basic flow path in , the first branch 11 and the second branch 12 are respectively combined and shared, and then access to the dry flow branch through the second port K2; and so on.

[0210] Figures 15A to 15C Among them, The combined flow path in

[0211] shows the combination of two different types of "1-basic type" variants, and the devices in series on the flow pipe are peristaltic pump and stop valve respectively, and their stop effects are the same.

[0212] Meanwhile, each BC type combined flow path can be provided with a liquid detector S on the branch pipe connected to the dry flow branch, for metering positioning, or detecting whether the liquid reaches the detection position, to ensure that the liquid does not enter the dry flow branch during metering according to the working condition.

[0213] It can be understood that the combined flow path scheme shown in Figures 15A to 15D is only an embodiment formed by combining the basic flow paths shown in Figures 1A-1E and Figures 2 to 6 in the BC type combined flow path, and the protection scope of the present application covers all permutation and combination forms. It can also be understood that, for example, the basic flow paths used to realize the combined flow path are not limited to the basic flow path schemes shown in Figures 1A-1E and Figures 2 to 6 , but the basic flow path scheme shown in Figures 7 to 10 may also be selected, and the basic flow path scheme not shown in the figure may also be selected.

[0214] Compared with the A type, P type, B type and C type combined flow paths, the BC type combined flow path has the beneficial effect of more effectively reducing the number of peristaltic pumps or stop valves, and accordingly saving costs and improving stability.

[0215] 3.5H type combined flow path:

[0216] The definition of the H type combined flow path is that the intersection points a of each type of basic flow path are merged and shared, and directly connected to the dry flow branch, and a peristaltic pump or a stop valve is connected in series on the dry flow branch; or, one or several first branches or second branches in the basic flow path are directly used as the dry flow branch. In the H type combined flow path, a peristaltic pump or a stop valve is connected in series on the through flow branch, the first branch 11 and the second branch 12 of all basic flow paths, and at least one peristaltic pump must be provided. Among all the first branches 11 and the second branches 12 described above, part of the first branches 11 or the second branches 12 are used as constant volume metering conduits, and the other first branches 11 or second branches 12 or the aforementioned dry flow branch can be used as the outlet for conveying liquid, as shown in FIG. 16. Through the above combination rules, multiple combined flow paths that can flexibly combine liquid (or can be used for liquid discharge) can be formed.

[0217] Figure 16A Two H type combined flow paths are shown, both of which use the basic flow path of FIG. 1 and share the intersection point a, and the difference lies in that a peristaltic pump is connected in series on the dry flow branch on the left, and a stop valve is connected in series on the dry flow branch on the right.

[0218] Figure 16B A more complex H type combined flow path is shown, and each branch above the three through flow branches below can be used as a constant volume metering conduit or a liquid output outlet.

[0219] Each of the above basic flow paths can be filled with liquid according to the aforementioned liquid filling principle and steps. However, when one of the through-flow pipes is working, the devices on the other basic flow paths should be in a static state (peristaltic pump is static, stop valve is closed) except for the devices on the first branch 11 or the second branch that work together. This will not be repeated here.

[0220] Compared with the A, P, B, C, and BC type combined flow paths, the biggest advantage of the H type combined flow path is flexibility in combination. With the least devices, liquid can be measured according to different specifications and then delivered to different ports (for example, multiple reactors / dishes) for subsequent processing.

[0221] The above describes in detail various combined schemes of the basic flow paths of the present application. In operation, the liquid in each container can be intercepted in a predetermined volume section, which can be performed simultaneously or selectively on one or several containers. Finally, the liquid is pushed out from the selected ports in sequence or simultaneously. Therefore, the above combined schemes of the basic flow paths can individually and simultaneously intercept a predetermined amount of liquid in multiple different containers according to a predetermined order, and deliver the high-precision intercepted liquid. Moreover, due to the combination of the basic flow paths, the use of components can be greatly reduced, thereby reducing the overall cost.

[0222] In addition, as described above, Figures 11A to 11C and Figures 12 to 16A and Figure 16B Various types of combined flow path schemes based on the basic flow paths are exemplarily shown, and the basic flow paths used to realize the combined flow paths are not limited to Figures 1A to 1E and Figures 2 to 6 the basic flow path schemes shown in Figures 7 to 10 the basic flow path schemes shown in the basic flow path schemes not shown in the figures. Various possible combinations of these basic flow paths are within the scope of the present application.

[0223] In addition, it should be noted that the liquid filling and / or liquid discharge in the above various combined flow paths can be realized according to various types of liquid filling and / or liquid discharge of the basic flow paths, and therefore these variations are within the scope of the present application.

[0224] IV. Application Flow Path Scheme

[0225] In the application flow path scheme, a reactor / dish 100 is included, which is used for reaction processing and / or detection analysis and has a top opening at the top and / or a bottom opening at the bottom; or each opening can not be provided, and each basic flow path and / or combined flow path can be allowed to enter the reactor / dish 100 through the top, middle, and / or bottom.

[0226] In order to inject the required predetermined liquid sample (with accurate volume) into the reactor / dish 100 for reaction treatment and / or detection analysis, the above basic flow path scheme and / or combined flow path scheme can be connected to the reactor / dish 100. Depending on the application conditions, the bottom opening can be connected to the reactor / dish 100, or the bottom opening and the top opening can be connected to the reactor / dish 100, or the bottom opening and the middle of the reactor / dish 100 can be connected to the reactor / dish 100. In other words, the bottom, top or middle of the reactor / dish 100 can be used as a connection access point. Preferably, a peristaltic pump or a stop valve is connected to the bottom opening of the reactor / dish 100 to keep the reaction liquid in the reactor / dish 100 or to discharge the liquid after the reaction is completed.

[0227] As shown in Figure 17 , the device (application flow path) for quantitative treatment of liquid has a reactor / dish 100 for reaction treatment and / or detection analysis, and has a top opening at the top. The top opening simultaneously connects various basic flow paths or various combined flow paths (or suitable combinations thereof). Each container of the various basic flow paths or various combined flow paths can be used to contain different liquids, such as distilled water, water sample to be detected, standard liquid, shielding agent, color developing agent, cleaning liquid, etc. The bottom of the reactor / dish 100 is connected to a peristaltic pump or a stop valve, preferably a forward and reverse driveable peristaltic pump (which can be used for downward liquid discharge and upward gas blowing to stir the liquid, respectively).

[0228] As shown in Figure 18 , the device (application flow path) for quantitative treatment of liquid has a reactor / dish 100 for reaction treatment and / or detection analysis, and has a top opening at the top and a bottom opening at the bottom. The top opening and the bottom opening simultaneously connect various basic flow paths or various combined flow paths (or suitable combinations thereof). Each container of the various basic flow paths or various combined flow paths can be used to contain different liquids, such as distilled water, water sample to be detected, standard liquid, shielding agent, color developing agent, cleaning liquid, etc.

[0229] As shown in Figure 19 and Figure 20As shown, the application flow path of the device for quantitative liquid treatment has a reactor / dish 100 for reaction treatment and / or detection analysis, and has a top opening at the top and a bottom opening at the bottom. The bottom opening is connected to various basic flow paths or various combined flow paths (or suitable combinations thereof). Alternatively, the reactor / dish 100 is not provided with an opening, and the at least one combined flow path is connected to the reactor / dish at the top and bottom of the reactor / dish. Each container of the various basic flow paths or various combined flow paths can be used to contain different liquids, such as distilled water, water samples to be detected, standard liquids, shielding agents, color developing agents, cleaning liquids, etc. When the bottom opening is connected to a basic flow path or a combined flow path, a waste liquid container (not shown) can be used to contain waste liquid, and a cleaning liquid can also be contained, and the cleaning liquid can be introduced into the reactor / dish 100 to facilitate cleaning of the reactor / dish 100.

[0230] As shown in FIG. 1, a basic flow path is formed around a reactor / dish 100. Multiple basic flow paths can be connected at the bottom and share one or more liquid outlets, allowing multiple reactors / dishes 100 to work simultaneously to greatly improve work efficiency. Figure 20 As shown in FIG. 1, a basic flow path is formed around a reactor / dish 100. Multiple basic flow paths can be connected at the bottom and share one or more liquid outlets, allowing multiple reactors / dishes 100 to work simultaneously to greatly improve work efficiency. Figure 23 As shown in FIG. 1, a basic flow path is formed around a reactor / dish 100. Multiple basic flow paths can be connected at the bottom and share one or more liquid outlets, allowing multiple reactors / dishes 100 to work simultaneously to greatly improve work efficiency.

[0231] Based on the above-mentioned connection mode of the basic flow path or the combined flow path to the reactor / dish 100, various application flow path combination schemes of the device for quantitative liquid treatment can be formed.

[0232] As shown in FIG. 1, a basic flow path is formed around a reactor / dish 100. Multiple basic flow paths can be connected at the bottom and share one or more liquid outlets, allowing multiple reactors / dishes 100 to work simultaneously to greatly improve work efficiency. Figures 21 to 23 As shown in FIG. 1, a basic flow path is formed around a reactor / dish 100. Multiple basic flow paths can be connected at the bottom and share one or more liquid outlets, allowing multiple reactors / dishes 100 to work simultaneously to greatly improve work efficiency.

[0233] Figure 21 The left side of the flow path uses a "1-K1-BC" type combined flow path to meter the distilled water and the water sample, which enters from the top of the reactor / dish 100. At the same time, the right side uses a "4-K1-B" type combined flow path to enter from the top of the reactor / dish 100, and the bottom of the reactor / dish 100 is connected to a peristaltic pump or a stop valve, preferably a forward and reverse driveable peristaltic pump (which can be used for downward liquid discharge and upward air blowing to stir the liquid, respectively). The advantage of this design is that the principle is simple, the structure is simple, the metering accuracy is high, the liquid metering of the water sample and the reagent can be performed simultaneously, time is saved, and the water sample and the reagent do not interfere with each other when entering, and there is no cross contamination.

[0234] Figure 22 The flow path is in Figure 21 The flow path is replaced with a "4-K1-BC" combined flow path on the basis of Figure 24 The bottom of the reactor / dish 100 is connected to a peristaltic pump or a stop valve. At the same time, two flow lines are connected at node b, respectively for discharging waste liquid and metering clean liquid. The design also has a liquid detector Sb in series with the pipeline at the bottom of the reactor / dish 100, which cooperates with the peristaltic pump below to realize the dilution operation of the liquid.

[0235] The specific operation process is as follows: first, the water sample is fed into the reactor / dish 100, then the liquid is discharged by the peristaltic pump Bb1 until the last liquid just passes through the liquid detector Sb, at which time the liquid discharge is stopped, and the peristaltic pump Bb1 or the peristaltic pump Bb2 is reversed to send the intercepted fixed volume of liquid back into the reactor / dish 100, then the peristaltic pump Bbn starts to feed distilled water, the volume of the liquid can be determined by the liquid detector Sb cooperating with the feeding time of the peristaltic pump Bbn, finally the peristaltic pump Bb1 or the peristaltic pump Bb2 is reversed to blow all the dilution liquid above the node b into the reactor / dish 100, completing the dilution of the original water sample. Compared with Figure 21 Compared with Figure 22 A flow path topology and dilution method for diluting water samples based on the flow path construction idea of the present application are described.

[0236] Figure 23 The left side of the flow path adopts a "1A-basic type" basic flow path to meter the liquid into the reactor / dish 100 from the top of the reactor / dish 100, and the right side uses two "4-basic type" basic flow paths to feed liquid from the top of the reactor / dish 100, and the bottom of the reactor / dish 100 is connected to a peristaltic pump or a stop valve, preferably a peristaltic pump that can be driven in both directions (which can be used to discharge liquid downward and blow gas upward to stir the liquid, respectively). Compared with Figure 21 Compared with the flow path, the advantage of this design is the complete separation of the two reagents on the right side, which eliminates any possibility of cross contamination.

[0237] As Figures 24 to 27As shown, both are the way of connecting the base flow path or combined flow path scheme to the bottom opening of the reactor / dish 100. In this embodiment, different types of liquid (such as water sample, shielding agent, color developing agent, etc.) can be relatively independently introduced into the reactor / dish 100 from below, and waste liquid can be received and cleaning can be performed. The beneficial effect of such design is that the same function devices such as peristaltic pumps, stop valves, liquid detectors on different combined branches can be used in combination, for example, pumps for draining or blowing, distilled water pumps for cleaning, liquid detectors for detecting liquid, etc., so as to simplify the flow path and save costs; in addition, the way of introducing and discharging liquid from the bottom of the reactor / dish 100 is also very beneficial to the cleaning of each pipeline, which is high in cleaning efficiency, saves cleaning water, and reduces the number of air ports and discharge ports.

[0238] As shown in the flow path, the "4-K1-BC" type combined flow path with liquid inlet at the top left of the reactor / dish 100 and the "4-K1-B" type combined flow path with liquid inlet at the top right of the reactor / dish 100 are moved to the bottom of the reactor / dish 100. Figure 24 Figure 22 As shown in the flow path, the "4-K1-BC" type combined flow path with liquid inlet at the top left of the reactor / dish 100 and the "4-K1-B" type combined flow path with liquid inlet at the top right of the reactor / dish 100 are moved to the bottom of the reactor / dish 100.

[0239] The application flow path for water treatment or detection will be described in detail below. Figures 25 to 28 As shown in the flow path, the "4-K1-BC" type combined flow path with liquid inlet at the top left of the reactor / dish 100 and the "4-K1-B" type combined flow path with liquid inlet at the top right of the reactor / dish 100 are moved to the bottom of the reactor / dish 100.

[0240] As shown in the flow path, the "4-K1-BC" type combined flow path with liquid inlet at the top left of the reactor / dish 100 and the "4-K1-B" type combined flow path with liquid inlet at the top right of the reactor / dish 100 are moved to the bottom of the reactor / dish 100. Figures 25 to 28 As shown in the flow path, the "4-K1-BC" type combined flow path with liquid inlet at the top left of the reactor / dish 100 and the "4-K1-B" type combined flow path with liquid inlet at the top right of the reactor / dish 100 are moved to the bottom of the reactor / dish 100.

[0241] In the application flow path, the liquid in the container can be distilled water, cleaning liquid, water sample to be measured, standard solution or reagent. Figures 25 to 27 ​In this configuration, the flow path of each container is connected to the same common conduit GL1. Figure 28 In this system, the flow channels of some containers are connected to a common channel GL1, while the flow channels of other containers are connected to another common channel GL2.

[0242] Each of the aforementioned common conduits is connected to an external branch (such as...). Figures 25 to 28 As shown in the diagram, WZ1 is connected to the atmosphere. Each external branch is equipped with peristaltic pumps Bd, Be, Bf, and Bg connected in series for pumping in and / or pumping out air, and / or discharging liquid. The implementation of this function can be found in the description of air pumping and liquid discharge in the basic flow path.

[0243] It should be emphasized that in the technical solution claimed in this application, the reactor / vessel 100 can have a detachable and combinable design with the application flow path. For example, the application flow path can be set in the flow path device, while the reactor / vessel 100 is a separate component, and the two can be combined and connected during use; or the application flow path can be integrated into a flow path module, and the reactor / vessel 100 can be used in combination with this flow path module. Of course, the reactor / vessel 100 can also be directly connected in the application flow path. Preferably, the application flow path includes the reactor / vessel 100, and all the common pipelines are connected to the reactor / vessel 100, such as... Figures 25 to 28 As shown.

[0244] The connection between the common conduit (such as GL1, GL2) and the reactor / vessel 100 can take several forms. For example, after the common conduit extends into the reactor / vessel 100, the opening of the common conduit can be located at the bottom, middle, or top of the reactor / vessel 100. As one alternative method, such as... Figure 28 As shown, the common conduit drips liquid into the reactor / vessel 100 through the top opening of the reactor / vessel 100. Alternatively, as described above, it can be connected to the top opening and / or bottom opening of the reactor / vessel 100; these connection methods are applicable to all embodiments of this application.

[0245] Figure 25 This paper presents a flow path that allows for a simpler liquid inlet function without reducing the amount of water sample and reagents. The flow path consists of a "4-K1-BC type" combined flow path connected to the reactor / vessel 100. The common pipe GL1 from point b to point d is equivalent to intersection point a in the "4-K1-BC type" combined flow path; the common pipe GL1 from point b to point a is equivalent to the first branch 11 in the "4-K1-BC type" combined flow path; and the first external branch WZ1, connected in series with a peristaltic pump Bd, is equivalent to the second branch 12 in the "4-K1-BC type" combined flow path, used for draining liquid or pumping air into the main flow path to push the metered liquid into the reactor / vessel 100.

[0246] The first external branch WZ1 is connected to the air / waste liquid bottle or air / flushing water bottle from the common pipeline GL1. The branches where the peristaltic pumps Bc, Brn, Br1 and Bb are located are the flow-through pipelines of the respective containers. The flow-through pipelines of the respective containers are connected to the same common pipeline GL1, which is connected to the atmosphere through the external branch WZ1 for pumping in and / or pumping out air, and can also discharge the reacted liquid.

[0247] The arrangement of the first external branch WZ1 is not limited to the mode shown in Figure 25 . For example, the first external branch WZ1 can be connected to the part of the common pipeline GL1 between the end away from the reactor / dish 100 and the node of the container connected to the reagent (i.e. the GZ1 part shown in Figure 25 ); or the first external branch WZ1 is connected to the part of the common pipeline GL1 between the end away from the reactor / dish 100 and the node of the container connected to the distilled water (for example, between the points c and rn shown in Figure 25 , after the flushing liquid / distilled water bottles Pc and Prn are interchanged). In a preferred case, the first external branch WZ1 is connected to the end of the common pipeline GL1, GL2 away from the reactor / dish 100, as shown in Figures 25 to 27 .

[0248] In all the application flow paths of the present application, the constant volume of the liquid when the liquid is pumped in can be realized by controlling the rotation speed and time of each liquid inlet peristaltic pump, or by positioning the liquid section head at a certain position near the liquid detector S, as shown in Figures 25 to 28 . The application flow path includes a liquid detector S arranged in the part of the common pipeline GL1 between the reactor / dish 100 and the node b of the flow-through pipeline closest to the reactor / dish 100 and the common pipeline GL1 (i.e. the GZ2 part shown in Figure 25 ). Therefore, when the liquid is pumped into the reactor / dish 100, the corresponding liquid section can be accurately intercepted by using the liquid detector S to realize accurate liquid constant volume, or to make a pre-warning judgment of whether the liquid passes through this point during the operation of the instrument.

[0249] Figure 25 The different metering principles and liquid inlet processes of the application flow paths shown in Figure 4 , and the BC type combined flow path shown in Figure 15B have been described in the introduction of the basic flow path shown in Figure 25 . In the following, we will introduce theThe high-precision liquid feeding of the reaction flow path is briefly described as follows: if water sample is needed, the peristaltic pump Bb is first rotated counterclockwise, the water sample is stopped when passing through the liquid detector S, and then the peristaltic pump Bb is stationary. Then, the peristaltic pump Bd of the first outer branch WZl is rotated counterclockwise, the water sample between the point b and the liquid detector S is injected into the reactor / dish 100 through air, thereby completing the high-precision liquid feeding of a micro-liquid volume (e.g. 0.005-2 ml). Then, the peristaltic pumps Bb and Bd are stationary, the peristaltic pump Br1 or Brn is rotated counterclockwise, the reagent is stopped when passing through the liquid detector S, and then the peristaltic pump Bd of the first outer branch WZl is rotated counterclockwise, the liquid between the point r1 (or rn) and the point S is sent into the reactor / dish 100 through air. The other liquids and reagents in the flow path can be metered and fed in this way. According to the operation, the determined volume of different liquids in different containers can be pushed into the reactor / dish 100 in a predetermined order, and then reactions and / or analysis can be performed in the reactor / dish 100.

[0250] The peristaltic pump Bd is rotated counterclockwise to blow air into the reactor / dish 100 to stir the liquid.

[0251] In the application flow path shown in Figure 26 Compared with the application flow path shown in Figure 25 The outer branch further comprises a second outer branch WZ2 which communicates with the waste liquid bottle Pf from the common pipeline GLl. Preferably, the second outer branch WZ2 is communicated with the part of the common pipeline GLl between the reactor / dish 100 and the node b between the nearest flow-through pipeline to the reactor / dish 100 and the common pipeline GLl (i.e. the GZ2 part shown in Figure 26 Therefore, in order to more accurately complete the liquid metering and volume setting, the liquid from the f point to the a point and above can also be emptied into the waste liquid bottle through the waste liquid branch by using the serial peristaltic pump Bf connected at the f point, at which time the right end position of the liquid accurate volume setting is positioned and realized by the position of the physical node f. Figure 26 The connection structure is shown. In addition, in the application flow path shown in Figure 26 Because the second outer branch WZ2 is separately provided, the waste liquid can be separately collected, thereby avoiding the cross contamination of the waste liquid to other water samples and reagents which can occur. The liquid feeding mode is similar to that of the embodiment shown in Figure 25 Therefore, the detailed description is not repeated here.

[0252] In order to more flexibly utilize the physical space volume between the nodes on the dry flow branch to perform the volume setting operation on the liquid to be intercepted, the designer can add some branches which communicate with air or liquid on the dry flow branch, so as to high-precisely intercept different micro-liquid volumes. Figure 27 An example is shown, as shown in Figure 27The application flow path shown has a new branch connecting to air or used for flushing water discharge added at point e between the reagent branch and the distilled water branch. This is to minimize the increase in waste liquid volume when flushing water is discharged from the second external branch WZ2, and to avoid cross-contamination of the reagent outlet caused by flushing water being discharged from the first external branch WZ1. This new branch is the third external branch WZ3, which connects to the air / flushing water bottle Pe from the common pipeline. Specifically, the third external branch WZ3 connects to the portion of the common pipeline GL1 located between the reactor / vessel 100 and the container connected to the reagent (i.e.,...). Figure 27 (GZ3 portion shown).

[0253] Below, we will use Figure 27 Taking this as an example, the basic principles and processes of metering, liquid inlet, stirring, liquid outlet, and dilution in this type of flow path are explained. It should be noted that... Figures 25 to 28 The corresponding principles and processes of other flow paths are similar, so the working process of similar application flow paths will not be described in detail.

[0254] Figure 27 The high-precision liquid injection metering process is as follows: If a water sample needs to be injected, the peristaltic pump Bb first rotates counterclockwise. The water sample passes through the liquid detector S, overflushes a certain volume, and then stops. Then, the peristaltic pump Bb comes to a standstill, and the peristaltic pump Bf rotates clockwise briefly to draw excess overflushing liquid (beyond point f) into the waste liquid outlet for discharge. This completes a high-precision injection of a small volume (e.g., 0.005-2 ml). Alternatively, we can use the colorimetric detector G in reactor / vessel 100 (which can be a dielectric sensor, pressure sensor, or optical sensor) to perform large-volume volumetric metering (e.g., when the liquid level reaches the horizontal line of the optical axis at point G, the device detects a signal, thus completing the positioning metering). Then, the peristaltic pumps Bb and Bf come to a standstill, and the peristaltic pump Bg or Be rotates counterclockwise to deliver the liquid between points b and f into reactor / vessel 100. Other liquids and reagents within the flow path can also be metered and injected using this method. By selecting different water head (referred to as "water head") cutoff points and air blowing points, designers can obtain micro-liquid injection volumes of varying sizes. Following this procedure, specific volumes of different liquids from different containers can be pushed into reactor / vessel 100 in a predetermined sequence, where reactions and / or analyses can then be carried out.

[0255] The peristaltic pumps Bg, Be, or Bf, when rotated counterclockwise, can all blow air into the reactor / vessel 100 to agitate the liquid. These three pumps can also serve as outlets for liquid discharge.

[0256] Figure 27The flow path realizes the dilution operation of the liquid in the reactor / dish 100 as follows: first, start the peristaltic pump Bg or Be to discharge the liquid, and pump the liquid to be diluted into the air / washing water discharge container. When the water tail does not pass point f, stop the peristaltic pump, then rotate the peristaltic pump Bf clockwise to discharge the excess liquid to be diluted outside point f, and then rotate the peristaltic pump Bg or Be counterclockwise to send the intercepted liquid into the reactor / dish 100. Finally, use the aforementioned metering liquid feeding mode to feed distilled water into the reactor / dish 100 in a micro-liquid or large-volume liquid feeding mode, and mix uniformly after blowing and stirring.

[0257] In order to completely avoid cross contamination between the reagent and the water sample (standard solution and distilled water), and at the same time, the water sample and the reagent can be fed simultaneously. Figure 28 An example of moving all reagent outlets to the top of the reactor / dish 100 is shown. Figure 28 In the embodiment shown, the flow paths of at least two of the plurality of containers are connected to a common pipe GL1, and the flow paths of the other containers are connected to another common pipe GL2. The opening of the common pipe GL1 is adjacent to the bottom opening of the reactor / dish 100, and the other common pipe GL2 is connected to and / or extends into the interior of the reactor / dish 100 or above the opening. By connecting the flow paths of the containers containing reagents and air to the common pipe GL1 respectively, and connecting the other flow paths to the other common pipe GL2, the simultaneous delivery of reagents and water samples is realized.

[0258] In the application flow path shown in Figures 22 to 28 At least one external branch is provided in the application flow path shown in the embodiment, which is the same as the external atmosphere. Preferably, the external branch is connected to the common pipe at the outermost end of the common pipe, which is farthest from the reactor / dish 100. Therefore, the peristaltic pump can realize accurate feeding of all reagent containers or reagent dishes on the common pipe into the reactor / dish 100.

[0259] Preferably, as shown in Figures 22 to 28 A liquid detector S is provided adjacent to the bottom opening of the common pipe, so that a volume of liquid between each branch point and the liquid detector S can be intercepted, thereby obtaining a liquid sample with higher precision in volume. The position of the liquid detector S can be anywhere between the branch point b and the bottom a of the reactor / dish 100. The advantages of the liquid detector S can be seen in the detailed description above.

[0260] In addition, in all application flow paths, the arrangement order of each container P relative to the reactor / dish 100 can be selectively designed according to the working procedure. For example, since it is necessary to push various reaction liquids with air, the peristaltic pump (e.g., Be) directly communicating with the atmosphere is preferably farthest from the reactor / dish 100 compared with the peristaltic pump in series with the passage pipeline of other containers.

[0261] As can be known from the foregoing description, it is obvious that in the embodiment shown in Figures 25 to 28 As shown in the embodiment, the combination of the basic flow path has achieved a high degree of dynamic integration. As shown in Figure 26 As shown, the reaction flow path further includes a waste liquid bottle Pf of the second outer branch, which is a container communicating with the atmosphere and has a waste liquid pipeline (i.e., the second outer branch) extending out of the waste liquid bottle Pf from the inside of the waste liquid bottle Pf, and a peristaltic pump Bf arranged in series in the second outer branch. As shown in Figure 26 As shown, the peristaltic pump Bd of the leftmost first outer branch directly communicates with the atmosphere, thereby being able to introduce air into the common pipeline GL1. At the same time, the waste liquid bottle Pf and the peristaltic pump Bf of the second outer branch are dedicated to the reception of waste liquid, thereby avoiding mutual interference when air is introduced; and since the waste liquid bottle Pf is relatively close to the reactor / dish 100, it is able to realize on-site liquid discharge, improve efficiency, and also avoid pollution of the waste liquid. The features of the waste liquid bottle Pf can also be applied to other suitable application flow paths.

[0262] In the embodiment shown in Figure 27 In the embodiment shown, an air / washing water discharge port container of a third outer branch is further added to play a dilution function. In the flow path of the present application, the method of realizing the dilution function is flexible, and in addition to the foregoing dilution scheme, different operations can also be used to realize the dilution function. Specifically, for the liquid in the reactor / dish 100 that needs to be diluted, first, under the condition that other peristaltic pumps are stationary, the peristaltic pump of the air / washing water discharge port container is rotated to suck the liquid to be diluted into the air / washing water discharge port container, at which time the liquid to be diluted is filled between the air / washing water discharge port and the bottom opening a. Then, the other peristaltic pumps are closed and only the peristaltic pump of the waste liquid bottle is rotated, so that the liquid to be diluted between the cross point f and the bottom opening a is discharged into the waste liquid. At this time, the liquid to be diluted is filled between the air / washing water discharge port and f. Then, the other peristaltic pumps are closed and only the leftmost peristaltic pump is operated, using air to push the liquid to be diluted between the cross points e and f into the reactor / dish 100. Distilled water is then sucked into the reactor / dish 100, thereby realizing the dilution process of the liquid to be diluted.

[0263] Figure 28 An example of moving the outlets of all reagents to the top liquid inlet of the reactor / dish 100 is shown, which is a "4-K1-BC type" combined flow path connected to the bottom and top of the reactor / dish. In Figure 28In the illustrated embodiment, at least two of the containers have their flow lines connected to a common conduit GL1, while the flow lines of the other containers are connected to another common conduit GL2. The opening of the common conduit GL1 is located adjacent to the bottom opening of the reactor / vessel 100, and the other common conduit GL2 connects to and / or extends into the interior of the reactor / vessel 100 or above its opening. By connecting the common conduit GL1 to a container containing reagents and an air flow line respectively, and the other common conduit GL2 connecting to other flow lines, the reagents and water samples can be delivered simultaneously and separately. Figure 28 A variation of the illustrated embodiment can be implemented in... Figure 28 Based on this, the "4-K1-BC" combined flow path is replaced with the "4-K2-BC" combined flow path. This will be described in detail below.

[0264] Figure 29 Shown in Figures 26 to 28 Based on the previous design, a "4-K2-BC type" combined flow path was adopted to replace the original separate inlet branches for water sample, standard solution, and distilled water. Since the first branch from c1 to Kc is shared, the inlet volumes of water sample, standard solution, and distilled water are consistent, and cross-contamination with reagents is less likely. If a larger volume of liquid needs to be measured, the c1-Kc conduit for volume determination can be replaced with a branch consisting of a thicker tube connected in series in the middle. The thicker tube must open upwards and its outlet must be higher than the bifurcation point c1 to ensure that liquid does not flow out of the outlet of the thicker tube.

[0265] Figure 30 It is Figure 29 The combined flow path for the water sample, standard solution, and distilled water inlet has been moved to the end of the main flow path (the far left end relative to reactor / plate 100). This configuration allows the Kc port to be used directly as an air port and a drain outlet for flushing water, while placing the water sample, standard solution, and distilled water at the far left end facilitates the metering of larger volumes of water sample, standard solution, and distilled water. The adjustment of the position of this similar basic or combined flow path on the main flow path can take many forms, not limited to the specific form shown in the figure; all these variations are within the scope of this application.

[0266] Figure 31 and Figure 32 They are respectively to Figure 29 and Figure 30 The "4-K2-BC type" combined flow path of the main branch has been replaced with another flow path, and the new flow path type of the main branch is "1-K1-P type". Its liquid inlet method and process can be found in the foregoing description of this application.

[0267] Figures 25 to 32The application flow path is characterized in that the first branch 11 matched with each liquid inlet and outlet port is combined and shared, and / or the second branch 12 is combined and shared, so that the devices (peristaltic pump, stop valve or liquid detector) used by the application flow path are reduced as much as possible, thereby simplifying the flow path and reducing the cost.

[0268] In Figures 25 to 32 In the application flow path of

[0269] Figure 33 In the application flow path of Figure 29 The through pipe of the reagent 1 to the reagent n is replaced by the "4-basic type" flow path (N above-mentioned reagent inlet flow paths constitute a "4-K2-BC" combined flow path). The greatest advantage of this type of flow path is that the concurrent metering and constant volume of water sample and each reagent can be realized, and then the liquid can be quickly introduced in sequence according to the process requirements. Also, simultaneous cleaning of each branch can be realized, thereby greatly saving the full cycle detection time of the instrument.

[0270] It should be noted that the outlet of the first branch 11 of the above-mentioned reagent "4-basic type" flow path still returns to the reagent bottle container P. The advantage of this is that the reagent pumped out by the peristaltic pump returns to the reagent bottle, thereby saving the reagent and eliminating the influence of the gas bubbles that may be originally contained in the pipe (such as a fine channel). By increasing the rotation time of the peristaltic pump, the stability and high precision of the entire liquid inlet system are ensured. This structural feature and its beneficial effects can be applied to all flow paths submitted in this application.

[0271] Figure 34 Another practical application flow path is shown, in which the water sample, the standard solution and the distilled water are respectively completed by the "4-basic type" flow path on the respective first branch in parallel, and then connected to the upper level "4-basic type" flow path, and finally connected to the bottom of the reactor / dish 100. Each reagent is connected to the top opening of the reactor / dish 100 in the same way. The advantage of this flow path is that each liquid is independently metered and introduced, which is fast. Especially when diluted, the distilled water for dilution is ready, so the dilution speed of this flow path will be very fast. In order to further reduce the devices, the "air / washing water outlet" peristaltic pump of the upper and lower dry flow branches of the application flow path can be omitted, and the air or washing water is directly discharged from the Kb / Kc / Kd ports.

[0272] Figure 35 An application flow path is shown, which uses a stop valve group (F3, F4, …, Fn in the dashed box) and a peristaltic pump Bc2, which functionally replaces Figure 33The multiple branch lines connected with the lower end of the C1 point are connected with the peristaltic pump. The stop valve group can also be replaced by an N-to-1 multi-channel switch valve.

[0273] Figure 36 A multiple detection index extension application flow path based on the Figure 33 The reagents of four different detection indexes (COD, ammonia nitrogen, total phosphorus, and total nitrogen) are respectively connected with the main line flow path below the reactor / pan by different nodes h, g, t, and r. The reactor / pan 100 is shared by the four indexes, and the water sample, standard solution, and distilled water inlet channels are connected with the main line flow path below the reactor / pan from the C point, and the liquid discharge and pump-in air are also shared and driven by the peristaltic pump Bf and the peristaltic pump Bq. The application flow path can be easily extended to realize the function of detecting the four indexes in sequence in time by only adding a few peristaltic pumps and their control devices at a low cost.

[0274] Figure 37 The flow path of the Figure 36 The distilled water branch line in the flow path is separated from the “4-basic type” flow path structure, and can be used to complete the metering and constant volume of the dilution liquid distilled water in advance during the dilution operation, thereby reducing the standby liquid time of the dilution operation.

[0275] Figure 38 The flow path of the Figure 39 is another practical application flow path type. In the Figure 38 , the main body connected at the bottom of the reactor / pan is a “5-K2-P type” (or “6-K2-P type”) combined flow path, and the connection on each intersection b, c, d, e, r, and rn is a “5-basic type” (or “6-basic type”) flow path. There is an “air / washing water / waste liquid discharge port” on the left side and the right side of the flow path, respectively, to realize the functions of rapid liquid inlet and discharge and complete dilution. It should be noted that the peristaltic pump B at the bottom of the reactor / pan 100 can also be located on the pipeline connected at the top.

[0276] Figure 39 The flow path of the Figure 37 is a combined idea, in which all “4-basic type” flow paths and “4-K2-A type” combined flow paths in the Figure 37 are replaced by “5-basic type” (or “6-basic type”) flow paths and “5-K2-P type” (or “6-K2-P type”) combined flow paths, respectively.

[0277] In order to realize the function of measuring more indexes (more reagents are needed) or more functions with as few devices as possible, for example, in the analyzer for total phosphorus and total nitrogen, one reagent is the same, and the customer hopes to have an instrument with a two-in-one function that can measure total phosphorus and total nitrogen at the same time. Figures 40 to 42 provides several flow paths to solve the above problems.

[0278] Figure 40 is Figure 36 , a reactor / dish is added in parallel beside the original reactor / dish 100 through the cross point c. A stop valve Fc / Fw is connected in series on the bottom pipeline of each of the two reactors / dishes. By controlling the opening and closing of the stop valves Fc and Fw, the index reagents connected below the main flow path can be respectively introduced into the two different reactors / dishes, so as to realize the simultaneous detection of two indexes.

[0279] Figure 41 is Figure 39 , a reactor / dish is added in parallel beside the original reactor / dish 100 through the cross point c. A peristaltic pump Bc / Bw is connected in series on the bottom pipeline of each of the two reactors / dishes. By controlling the rotation and stop of the peristaltic pumps Bc / Bw, the index reagents connected below the main flow path can be respectively introduced into the two different reactors / dishes, so as to realize the simultaneous detection of two indexes. The peristaltic pumps can also be connected in series on the top sealing pipeline of the reactors / dishes

[0280] Figure 42 shows a practical application flow path based on the H-shaped combined flow path. With few peristaltic pumps, stop valves, liquid detectors and two reactors / dishes, the flow path can realize the simultaneous detection of total phosphorus and total nitrogen, and one reagent port for the two indexes can be shared with the water sample, standard solution and distilled water ports.

[0281] Taking the measurement of a water sample as an example, the specific liquid inlet and outlet processes are as follows: before operation, all the stop valves and peristaltic pumps on the branches are in the closed or static state. First, the stop valve Fe is opened, and the peristaltic pump Be1 is counterclockwise rotated, so that the water sample is introduced into the e-Ke section and overflowed and constant volume is achieved; then the peristaltic pump Be1 is closed, and the peristaltic pump Bk is counterclockwise rotated, so that the water sample is pumped from the e-Ke section into the left reactor / dish, and then the water sample is sent into the right reactor / dish by the same method. Then, the reagents are sequentially constant volumeed in the pipeline (such as a fine channel) r-Kr1 or the pipeline (such as a fine channel) rn-Krn, and pumped into the left and right different reactors / dishes to start the reaction detection; after the detection is completed, the peristaltic pumps Bx, Bf, Bk and B1 are clockwise rotated (usually the flow rates of Bx and Bf are greater than those of Bk and B1), so that the liquid is discharged.

[0282] As Figures 21 to 42Figures 1 to 8 are schematic views of reaction flow paths of preferred embodiments of the present application, the working processes of which can be selected and applied in combination with the basic flow path and the combined flow path. As shown in the accompanying drawings, the arrows in the figures can be used to make corresponding explanations, or to indicate the replacement of adjacent illustrations. The zigzag lines can represent relatively long pipelines. In addition, some ports can be backflowed into the container P to achieve liquid conservation when overflowing, while avoiding pollution of the external environment.

[0283] In addition, it should be explained that, in the description of the working processes of the above basic flow path, combined flow path and application flow path, the liquid inlet and outlet processes of various basic flow paths are described in detail, and the liquid inlet and outlet processes of some embodiments of various combined flow paths and application flow paths are described in detail by way of example, but it can be understood by those skilled in the art that, on the basis of the liquid inlet and outlet processes of the basic flow path, in the combined flow path and application flow path and various modified combined embodiments thereof, the various possible embodiments of simultaneous and / or sequential performance of the liquid inlet and outlet processes of various basic flow paths are fully utilized, and are within the scope of the present application, and are not limited to the embodiments explicitly disclosed in the present application and the accompanying drawings.

[0284] The preferred embodiments of the present application are described in detail above in combination with the accompanying drawings, but the present application is not limited to the specific details of the above embodiments, and various simple modifications can be made to the technical solutions of the present application within the scope of the technical concept of the present application, and these simple modifications all belong to the protection scope of the present application.

[0285] For example Figure 43 The application flow path shown in FIG. 8, Figure 43 shows an example of moving the outlets of all reagents to the top liquid inlet of the reactor / dish 100, which is connected with the “4-K1-BC type” combined flow path at the top of the reactor / dish, and the “4-K2-BC type” combined flow path at point b at the bottom of the reactor / dish. Figure 43 is based on Figure 28 the “4-K2-BC type” combined flow path is used to replace the original separate branch structure of the water sample, standard solution, distilled water, air and flushing water. Specifically, as shown in Figure 43 a plurality of liquid quantity treatment devices are connected to the one common pipeline GL2, and the liquid quantity treatment device includes:

[0286] containers P3, P4 and P5 for containing the liquid to be extracted;

[0287] a through-flow pipeline 10 extending from the inside of the container to the bifurcation point b1, and the through-flow pipeline 10 is provided with a peristaltic pump B3, B4 and B5 in series;

[0288] a first branch 11 which communicates with the through-flow line 10 and extends from the branching point bl to a first port Kb which opens to the atmosphere; and

[0289] a second branch 12 which communicates with the through-flow line 10 and extends from the branching point bl to a second port b, a peristaltic pump Bb or a stop valve being arranged in series in the second branch 12, wherein at least some of the plurality of devices for dosing liquid share the first branch 11 and / or the second branch 12.

[0290] Preferably, the first branch 11 and / or the second branch 12 is a fine channel having a pore size of 0.05 mm to 5 mm, preferably 0.1 mm to 3 mm, and more preferably 0.5 mm to 2 mm. Preferably, the through-flow line 10 is also a fine channel, or the through-flow line 10 is a fine channel in a predetermined length range extending from the branching point bl towards the container P, the predetermined length range being at least 0.01 mm.

[0291] It should be further noted that any technically feasible combination of the various technical features described in the above embodiments is possible, provided that there is no contradiction. In order to avoid unnecessary repetition, the present application does not describe each and every possible combination of the various features described. However, this does not mean that the present application does not pertain to any combination of the features described, but rather that any such combination is possible and should be considered disclosed by the present application. Furthermore, any combination of the various embodiments described in the present application is possible, provided that there is no contradiction.

Claims

1. An application flow path for water treatment or detection, characterized by, The application flow path comprises: a plurality of containers (Pb, Pc, Pr1,..., Prn; Ph1,..., Phn) for containing liquid to be extracted, the throughflow conduits of each of the containers being connected to a common conduit, or the throughflow conduits of some of the containers being connected to one common conduit and the throughflow conduits of the other containers being connected to another common conduit, and a peristaltic pump being arranged in series on the throughflow conduit of each container; at least one outer branch, each of the common conduits being connected to the atmosphere through an outer branch in which a peristaltic pump (Bd, Be, Bf, Bg) is arranged in series, for pumping in and / or pumping out air and / or for discharging liquid; a reactor / dish (100) to which the common conduits are connected; wherein the outer branch comprises a first outer branch (WZ1) which connects an air / waste liquid bottle or an air / rinse water bottle from the common conduit; wherein, for any one of the containers, when the peristaltic pump on the first outer branch (WZ1) is stationary, the peristaltic pump on the throughflow conduit of the container is rotated to cause the liquid in the container to reach a constant volume position; then the peristaltic pump on the throughflow conduit of the container is stationary, and the peristaltic pump on the first outer branch (WZ1) is rotated to send the liquid in the throughflow conduit of the container from the connection position of the throughflow conduit and the common conduit to the constant volume position into the reactor / dish (100) through air; the constant volume position is a position near a liquid detector (S) arranged in the common conduit between the reactor / dish and the node of the throughflow conduit closest to the reactor / dish (100) and the common conduit; or the outer branch comprises a second outer branch (WZ2) which connects a waste liquid bottle from the common conduit, and the second outer branch is connected to the part of the common conduit between the reactor / dish (100) and the node of the throughflow conduit closest to the reactor / dish (100) and the common conduit, and the constant volume position is the connection point of the second outer branch and the common conduit; the common conduit and the outer branch are fine channels, and the inner diameter of the fine channels is 0.05mm to 5mm; the throughflow conduit is also a fine channel; or the throughflow conduit is a fine channel in a predetermined length range extending from the connection point (rb, rc, r1,..., rn) on the common conduit to the container (Pb, Pc, Pr1,..., Prn; Ph1,..., Phn), and the predetermined length range is at least 0.01mm.

2. The flow path for water treatment or detection according to claim 1, wherein The inner diameter of the fine channel of the common conduit and / or the outer branch is 0.1mm to 3mm.

3. The flow path for water treatment or detection according to claim 2, wherein The inner diameter of the fine channel of the common conduit and / or the outer branch is 0.2mm to 2mm.

4. The flow path for water treatment or detection according to claim 1, wherein The opening of the common conduit is located at the bottom, middle or upper part of the reactor / dish (100); and / or the common conduit drips liquid into the reactor / dish through the top opening of the reactor / dish (100); and / or, The liquid in the container is distilled water, cleaning liquid, water sample to be tested, standard solution or reagent.

5. The flow path for water treatment or detection according to claim 1, wherein The throughflow lines of at least some of the plurality of containers are connected to one common line (GL1), and the opening of the one common line (GL1) is located at the bottom of the reactor / dish (100).

6. The flow path for water treatment or detection according to claim 5, wherein The first outer branch (WZ1) is connected to the one common line (GL1) at a portion (GZ1) away from the end of the reactor / dish (100) and the node of the container connected to the reagent, or The first outer branch (WZ1) is connected to the one common line (GL1) at a portion (GZ1) away from the end of the reactor / dish (100) and the node of the container connected to the reagent, or The first outer branch (WZ1) is connected to the one common line (GL1) at a portion (GZ1) away from the end of the reactor / dish (100) and the node of the container connected to the reagent, or The first outer branch (WZ1) is connected to the one common line (GL1) at a portion (GZ1) away from the end of the reactor / dish (100) and the node of the container connected to the reagent, or 7. The flow path for water treatment or detection according to claim 6, wherein The application flow path includes a liquid detector (S) arranged in the one common line (GL1) at a portion (GZ2) between the reactor / dish (100) and the node of the throughflow line closest to the reactor / dish (100) and the one common line (GL1).

8. The flow path for water treatment or detection according to claim 5, wherein The outer branch includes a third outer branch (WZ3) connected to the common line and connected to an air / washing water bottle, The third outer branch (WZ3) is connected to the one common line (GL1) at a portion (GZ3) between the reactor / dish (100) and the node of the container connected to the reagent.

9. The flow path for water treatment or detection according to claim 1, wherein The throughflow lines of at least two containers of the plurality of containers are connected to one common line (GL1), and the throughflow lines of other containers are connected to another common line (GL2), and the opening of the another common line (GL2) is arranged adjacent to the opening at the bottom of the reactor / dish (100), and the one common line (GL1) is connected to and / or extends into the interior or above the opening of the reactor / dish (100).

10. The flow path for water treatment or detection according to claim 9, wherein The one common line (GL1) is connected to the throughflow line of the container containing the reagent and the throughflow line of the air, respectively, and the another common line (GL2) is connected to other throughflow lines.

11. The flow path for water treatment or detection according to claim 9, wherein The another common line (GL2) is connected to a plurality of liquid dosing devices, and the liquid dosing device includes a first branch (11) and a second branch (12): The portion of the throughflow line (10) connected to the another common line (GL2) extends outward from the interior of the container to a branching point (b1); The first branch (11) is connected to the throughflow line (10) and extends from the branching point (b1) to a first port (Kb) open to the atmosphere; and The second branch (12) is connected to the throughflow line (10) and extends from the branching point (b1) to a second port (b), and a peristaltic pump (Bb) is arranged in series in the second branch (12), and the second port (b) is connected to the another common line (GL2).

12. The flow path for water treatment or detection according to claim 11, wherein The first branch (11) and / or the second branch (12) is a fine channel, the aperture of which is 0.05mm to 5mm; or the throughflow conduit (10) is also a fine channel; or the throughflow conduit (10) is a fine channel in a predetermined length range extending from the bifurcation point (b1) towards the container (P), the predetermined length range being at least 0.01mm.

13. The flow path for water treatment or detection according to claim 12, wherein The aperture of the fine channel of the first branch (11) and / or the second branch (12) is 0.1mm to 3mm.

14. The flow path for water treatment or detection according to claim 13, wherein The aperture of the fine channel of the first branch (11) and / or the second branch (12) is 0.5mm to 2mm.

15. The flow path for water treatment or detection according to any one of claims 1 to 14, wherein The reactor / dish (100) is provided with a detector (G) for detecting the liquid level or liquid volume inside the reactor / dish (100), the detector (G) being a dielectric sensor, a pressure sensor or an optical sensor.

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