A topical nasal medication system

Abstract

This invention discloses a nasal topical medication application system, relating to the technical field of nasal topical medication application devices. To improve the medication application effect, the device includes a receiving bottle with a dispensing section at its top. Delivery pipes are fixed to the inner walls of both sides of the top of the receiving bottle via fixed supports. The delivery pipes are located at the center of the inner side of the dispensing section, and an airflow channel is provided between the delivery pipes and the dispensing section. The system includes the aforementioned medication application device, as well as a nasal topical medication formula and a preparation method for the formula. The formula includes the following components: seawater and purified water. This invention features a stirring mechanism. The user can press the connecting rod to apply an axial force to the rotating column. The sliding ball and the spiral groove form a sliding engagement, causing the rotating column to rotate, which in turn drives the stirring part to rotate, achieving stirring and avoiding uneven mixing of the drug components, thus improving the medication application effect.

Description

Technical Field

[0001] This invention relates to the field of nasal topical medication application devices, and more particularly to a nasal topical medication application system. Background Technology

[0002] The nose is frequently affected by adverse external factors, making it prone to various diseases. Microbial infections can cause nasal boils, nasal vestibule inflammation, and inflammation of the nasal cavity and sinuses. The nasal cavity is the gateway for allergens to enter the body and the site of allergic reactions, so hay fever and allergic rhinitis are common diseases. Currently, the treatment of nasal diseases often involves topical medication. Most current medication devices are squeeze-type, which can meet certain usage needs, but when the medication is left for a long time, sedimentation may occur, resulting in poor mixing of drug components and affecting the efficacy of the medication. Therefore, improvements are needed.

[0003] A search revealed Chinese patent application CN201921529645.9, which discloses a nasal medication application device. The device includes a medication application container with an application hole on its outer wall, a piston slidably embedded in its inner wall, and a dispensing hole on the extended end of the container away from the piston. A medication application plate is mounted parallel to the dispensing hole on the outer wall of the container. A groove is formed parallel to the length direction on the outer wall of the container, and a buffer block is slidably connected to the inner side of the groove. The buffer block and the inner side of the groove are elastically connected by a spring. The nasal medication application device in the aforementioned patent has the following shortcomings: although it can meet certain usage needs, sedimentation may occur when the medication is left for a long time, resulting in poor mixing of the medication components and affecting the medication's effectiveness. Therefore, further improvement is needed. Summary of the Invention

[0004] The purpose of this invention is to address the shortcomings of existing technologies by proposing a topical nasal medication system.

[0005] To achieve the above objectives, the present invention adopts the following technical solution:

[0006] A nasal topical medication application device includes a receiving bottle with a medication dispensing section at the top. Delivery pipes are fixed to the inner walls of both sides of the top of the receiving bottle via fixed brackets. The delivery pipes are located at the center of the inner side of the medication dispensing section. An airflow channel is provided between the delivery pipes and the medication dispensing section, and a diaphragm is installed within the airflow channel. The delivery pipes are slidably connected to the inner wall of the diaphragm, and the bottom end of the delivery pipes is located at the bottom of the receiving bottle. An agitation mechanism is provided inside the receiving bottle, comprising a fixed sleeve, a rotating column, and an agitating part. The fixed sleeve is laterally fixed to the center of the receiving bottle via a fixing bracket. At the core position, the outer circumferential wall of the rotating column is provided with a circumferentially distributed spiral groove, and the inner wall of one end of the fixed sleeve is provided with a sliding ball adapted to the spiral groove, the sliding ball being slidably connected in the spiral groove; the stirring part is provided at the end of the rotating column away from the fixed sleeve; a connecting part is connected to the inner wall of one end of the rotating column, the connecting part including a connecting rod and a first limiting head, the first limiting head being rotatably connected to the inner wall of one end of the rotating column, the connecting rod being provided on the outer wall of one side of the first limiting head, and extrusion parts are provided on the extrusion walls on both sides of the container bottle, one end of the connecting rod being fixed to the extrusion part.

[0007] Preferably, the stirring part includes stirring blades and stirring cover. The stirring blades are evenly distributed circumferentially on one side wall of the rotating column, and the stirring cover is fixed to one side wall of the stirring blades. The outer wall of one side of the stirring cover is provided with evenly distributed micropores.

[0008] Furthermore: the dispensing part includes a nozzle and an annular pleated part. The annular pleated part is bonded between the outer wall of the top of the container and the outer wall of the bottom of the nozzle. The annular pleated part is made of elastic silicone material. The bottom side wall of the nozzle is provided with an annular protrusion. A rotating ring is rotatably connected between two annular protrusions. A threaded ring is fixed to the bottom of the rotating ring through a connecting post. An annular threaded seat is provided on the outer wall of the top of the container. The threaded ring is installed on the outer wall of the annular threaded seat in an adjustable manner through threads.

[0009] A further preferred embodiment: a spring is fixed to one end of the rotating column, the spring is installed inside the fixed sleeve, a guide rod is fixed to the inner wall of the fixed sleeve, a second limiting head is provided at one end of the guide rod, and the second limiting head is slidably connected to the inner wall of the rotating column.

[0010] As a preferred embodiment of the present invention: a dosing port is provided on one side of the outer wall of the container, and a sealing cap is detachably installed on the outer wall of the dosing port by means of threads.

[0011] As a further preferred embodiment of the present invention: a top cap is fitted onto the top of the nozzle, and a silicone body is adhered to the inner wall of the top cap; the silicone body is elastically deformed and connected to the outer wall of one end of the nozzle.

[0012] As a further embodiment of the present invention: the top of the conveying pipe is integrally provided with evenly distributed branched pipes, the top outer wall of the diaphragm is provided with evenly distributed cross-shaped micro-holes, and the bottom end of the conveying pipe is bonded with a counterweight ball, the counterweight ball having a hollow structure and the outer wall of the counterweight ball being provided with evenly distributed through holes.

[0013] A nasal topical medication system includes the above-mentioned medication application device, and also includes a nasal topical medication formulation and a method for preparing the formulation, wherein the formulation includes the following components: seawater and purified water;

[0014] The formulation is divided into physiological solution formulation and high-concentration solution formulation based on the final sodium chloride concentration. The specific components of the physiological solution formulation are: 15-20% seawater, 80-85% purified water, with sodium chloride content controlled at 8.5-10.4 g / L, pH value at 6.5-8.0, and density (20℃) at 0.996-1.082 g / ml.

[0015] The specific components of the high-concentration medicine formula are: 45-50% seawater, 50-55% purified water, sodium chloride content controlled at 21.50-24.50 g / L, pH value of 6.5-8.5, and density (20℃) of 0.996-1.082 g / ml.

[0016] Based on the aforementioned scheme, the preferred preparation method includes the following steps:

[0017] S1: Purify and filter seawater raw materials and sterilize them;

[0018] S2: Purified water is obtained by using reverse osmosis (RO) to process pure water.

[0019] S3: Mix the purified water with the treated seawater in the specified proportion;

[0020] S4: Stir to mix the two thoroughly;

[0021] S5: Test and treat the mixed water to meet the standards before bottling;

[0022] S6: Obtain nasal drops.

[0023] Further optimization based on the aforementioned scheme: the Pb content in the final nasal solution should be less than three parts per ten million, the total bacterial count (cfu / mL) should be ≤100, and the total fungal count (cfu / mL) should be ≤10.

[0024] The beneficial effects of this invention are as follows:

[0025] 1. This invention, through the design of a receiving bottle and a delivery tube, allows the following: When the dispensing section faces upwards, the user squeezes the receiving bottle, reducing its volume. Since the gap between the delivery tube and the diaphragm is smaller than the inner diameter of the delivery tube, the liquid medicine in the receiving bottle is transported upwards through the delivery tube under air pressure. Simultaneously, the diaphragm deforms under air pressure, and some gas is discharged from the gap between the diaphragm and the delivery tube, assisting in the delivery of the liquid medicine emerging from the top of the delivery tube. The liquid medicine and gas are simultaneously output from the dispensing section, achieving a spray effect. When the dispensing section faces downwards, the liquid medicine gathers at the diaphragm due to gravity. When the receiving bottle is squeezed, the liquid medicine first enters the airflow channel and flows out directly from the dispensing section in a stream. This design provides two different drug delivery methods, enhancing the flexibility of use.

[0026] 2. Due to the agitation mechanism, the user can press the connecting rod to apply an axial force to the rotating column. The sliding ball and the spiral groove form a sliding fit, which causes the rotating column to rotate, thereby driving the agitator to rotate and achieve stirring. This avoids uneven mixing of drug components and improves the drug application effect.

[0027] 3. By setting up a stirring blade and a stirring cover, the liquid medicine in the container can be stirred based on the rotation of the rotating column, ensuring the quality of the liquid medicine output and improving reliability; by setting up structures such as annular pleats, threaded rings and annular threaded seats, the threaded ring can be raised and lowered by rotating the threaded ring. In this way, with the deformation and stretching of the annular pleats, the annular protrusion can be raised and lowered by using the rotating ring to change the distance between the nozzle and the delivery pipe, thereby changing the shape of the sprayed liquid medicine and meeting different usage requirements.

[0028] 4. By incorporating structures such as springs, the rotating column can be compressed and deformed when screwed into the fixed sleeve, allowing it to return to its original position after drug administration using the spring's rebound force, thus improving practicality; the second limiting head can limit the rotating column, preventing it from detaching from the fixed sleeve, thereby improving reliability.

[0029] 5. The addition of a dosing port and a sealing cap facilitates the replenishment of the medicine into the container, improving its practicality; the addition of a top cap and silicone body allows the nozzle to be sealed when not in use, preventing medicine leakage and further enhancing its practicality.

[0030] 6. By setting multiple branched tubes and cross-shaped micro-holes, the liquid medicine can be divided into multiple streams when it is delivered to the airflow channel. In addition, when the container bottle is pressed, the internal pressure increases, which causes the cross-shaped micro-holes to deform and expand, squeezing the airflow upward from the cross-shaped micro-holes to assist in the delivery of multiple streams of liquid medicine and improve the atomization effect. By setting up structures such as counterweight balls, the counterweight balls can be used to fall naturally under their own weight, thereby ensuring that one end of the delivery tube is always in the liquid medicine and can better squeeze out the liquid medicine. Attached Figure Description

[0031] Figure 1 This is a schematic diagram of the structure of a topical nasal medication application device proposed in this invention;

[0032] Figure 2 This is a cross-sectional structural schematic diagram of a topical nasal medication application device proposed in this invention;

[0033] Figure 3 for Figure 2 Enlarged view of point A in the middle;

[0034] Figure 4 This is a schematic diagram showing the disassembled structure of the stirring mechanism of a topical nasal medication application device proposed in this invention;

[0035] Figure 5 This is a cross-sectional schematic diagram of a fixing sleeve for a topical nasal medication application device proposed in this invention;

[0036] Figure 6 This is a schematic diagram of the rotating column and slider of a nasal topical medication application device proposed in this invention;

[0037] Figure 7 This is a cross-sectional schematic diagram of a nasal topical medication application device according to Embodiment 2 of the present invention;

[0038] Figure 8 for Figure 7 Enlarged view of point B in the middle;

[0039] Figure 9 This is a structural schematic diagram showing the comparison of the effects of different drug application methods in the experiments of this invention;

[0040] Figure 10 This is a graph showing the relationship between the proportion of seawater and the effect of flushing therapy in the experiments of this invention;

[0041] Figure 11 This is a graph showing the relationship between the proportion of seawater and the effect of osmotic therapy in the experiments of this invention;

[0042] Figure 12 This is a graph showing the relationship between the inner diameter of the bifurcation tube and the treatment effect in the experiment of this invention.

[0043] In the diagram: 1. Container bottle, 2. Extrusion wall, 3. Extrusion section, 4. Sealing cap, 5. Rotating ring, 6. Top cap, 7. Threaded ring, 8. Dosing port, 9. Delivery pipe, 10. Stirring blade, 11. Stirring cover, 12. Connecting part, 13. Micropore, 14. Annular protrusion, 15. Annular pleated part, 16. Annular threaded seat, 17. Fixed bracket, 18. Connecting column, 19. Nozzle, 20. Silicone body, 21. Fixed sleeve, 22. Connecting rod, 23. Fixed frame, 24. Spring, 25. First limiting head, 26. Rotating column, 27. Guide rod, 28. Second limiting head, 29. Spiral groove, 30. Sliding ball, 31. Diaphragm, 32. Counterweight ball, 33. Through hole, 34. Bifurcation tube, 35. Cross micropore. Detailed Implementation

[0044] The technical solution of this patent will be further described in detail below with reference to specific embodiments.

[0045] The embodiments of this patent are described in detail below. Examples of these embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals denote the same or similar elements or elements having the same or similar functions throughout. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain this patent, and should not be construed as limiting this patent.

[0046] In the description of this patent, it should be understood that the terms “center,” “upper,” “lower,” “front,” “back,” “left,” “right,” “vertical,” “horizontal,” “top,” “bottom,” “inner,” and “outer,” etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are used only for the convenience of describing this patent and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this patent.

[0047] In the description of this patent, it should be noted that, unless otherwise explicitly specified and limited, the terms "installation," "connection," "linking," and "setting" should be interpreted broadly. For example, they can refer to a fixed connection or setting, a detachable connection or setting, or an integral connection or setting. Those skilled in the art can understand the specific meaning of the above terms in this patent according to the specific circumstances.

[0048] Example 1:

[0049] A device for applying medication to the nose, such as Figure 1-7As shown, the container includes a receiving bottle 1, with a dispensing section at the top. A delivery pipe 9 is fixed to the inner walls of both sides of the top of the receiving bottle 1 via a fixing bracket 17. The delivery pipe 9 is located at the center of the inner side of the dispensing section. An airflow channel is provided between the delivery pipe 9 and the dispensing section, and a diaphragm 31 is installed within the airflow channel. The delivery pipe 9 is slidably connected to the inner wall of the diaphragm 31, with its bottom end located at the bottom of the receiving bottle 1. An agitation mechanism is provided inside the receiving bottle 1. The agitation mechanism includes a fixing sleeve 21, a rotating column 26, and an agitating part. The fixing sleeve 21 is laterally fixed to the center of the receiving bottle 1 via a fixing bracket 23. The outer circumferential wall of the rotating column 26 has circumferentially divided... The spiral groove 29 of the cloth has a ball joint 30 integrally provided on the inner wall of one end of the fixed sleeve 21, which is adapted to the spiral groove 29. The ball joint 30 is slidably connected to the spiral groove 29. It is worth noting that the pitch parameter of the spiral groove 29 should meet the condition that the spiral groove 29 can slide on the outer wall of the ball joint 30 by rotation when pushed along the axial direction of the rotating column 26. The agitator is provided at the end of the rotating column 26 away from the fixed sleeve 21. A connecting part 12 is connected to the inner wall of one end of the rotating column 26. The connecting part 12 includes a connecting rod 22 and a first limiting head 25. The first limiting head 25 is rotatably connected to the inner wall of one end of the rotating column 26. The connecting rod 22 is integrally provided with the inner wall of the rotating column 26. The first limiting head 25 is placed on one side of the outer wall. Squeezing sections 3 are provided on the squeezing walls 2 on both sides of the container bottle 1, and one end of the connecting rod 22 is fixed to the squeezing section 3. By setting up the container bottle 1, conveying pipe 9, and other structures, when the medicine outlet is facing upwards, the user squeezes the container bottle 1, causing the volume inside the container bottle 1 to decrease. Because the gap between the conveying pipe 9 and the diaphragm 31 is smaller than the inner diameter of the conveying pipe 9, the medicine in the container bottle 1 is conveyed upwards from the conveying pipe 9 under air pressure. At the same time, the diaphragm 31 deforms under air pressure, and some gas is discharged from the gap between the diaphragm 31 and the conveying pipe 9, assisting in the conveying of the medicine emerging from the top of the conveying pipe 9. The medicine and gas... Simultaneously, the medication is output from the dispensing section, achieving a spray effect. When the dispensing section is facing downwards, the liquid medication gathers at the diaphragm 31 due to gravity. When the receiving bottle 1 is squeezed, the liquid medication first enters the airflow channel and flows out directly from the dispensing section in streams. This design provides two different medication administration methods, improving the flexibility of use. In addition, due to the agitation mechanism, the user can press the connecting rod 22 to apply an axial force to the rotating column 26. The slider 30 and the spiral groove 29 form a sliding engagement, causing the rotating column 26 to rotate, which in turn drives the agitator to rotate, thereby achieving stirring and avoiding uneven mixing of drug components, thus improving the medication application effect.

[0050] To ensure the stirring effect; such as Figure 4As shown, the stirring part includes a stirring blade 10 and a stirring cover 11. The stirring blade 10 is evenly distributed circumferentially on one side wall of the rotating column 26. The stirring cover 11 is fixed to one side wall of the stirring blade 10. The outer wall of one side of the stirring cover 11 is provided with evenly distributed microholes 13. By setting the stirring blade 10 and the stirring cover 11, the liquid medicine in the container bottle 1 can be stirred based on the rotation of the rotating column 26, which ensures the quality of the liquid medicine output and improves reliability.

[0051] To facilitate adjustment of the spraying effect; such as Figure 2 , Figure 3 As shown, the dispensing section includes a nozzle 19 and an annular pleated section 15. The annular pleated section 15 is bonded between the top outer wall of the receiving bottle 1 and the bottom outer wall of the nozzle 19. The annular pleated section 15 is made of elastic silicone. An annular protrusion 14 is integrally provided on the bottom side wall of the nozzle 19. A rotating ring 5 is rotatably connected between two annular protrusions 14. A threaded ring 7 is fixed to the bottom of the rotating ring 5 through a connecting post 18. An annular threaded seat 16 is provided on the top outer wall of the receiving bottle 1. The threaded ring 7 is installed on the outer wall of the annular threaded seat 16 in an adjustable manner through threads. By setting up the annular pleated section 15, the threaded ring 7 and the annular threaded seat 16, the threaded ring 7 can be raised and lowered by rotating it. With the deformation and stretching of the annular pleated section 15, the rotating ring 5 supports the raising and lowering of the annular protrusion 14, thereby changing the distance between the nozzle 19 and the delivery pipe 9, thus changing the shape of the sprayed mist and meeting different usage requirements.

[0052] For ease of resetting; such as Figure 4 , Figure 5 As shown, a spring 24 is fixed to one end of the rotating column 26. The spring 24 is installed inside the fixed sleeve 21. A guide rod 27 is fixed to the inner wall of the fixed sleeve 21. A second limiting head 28 is provided at one end of the guide rod 27. The second limiting head 28 is slidably connected to the inner wall of the rotating column 26. By setting the spring 24 and other structures, the rotating column 26 can be squeezed and deformed when it is screwed into the fixed sleeve 21. After the drug administration is completed, the spring 24 can be used to reset the column, which improves its practicality. The second limiting head 28 can limit the rotating column 26 to prevent it from falling out of the fixed sleeve 21, which improves its reliability.

[0053] To facilitate replenishment of the medication; such as Figure 1 As shown, a dosing port 8 is provided on one side of the outer wall of the container bottle 1, and a sealing cap 4 is detachably installed on the outer wall of the dosing port 8 by means of threads; by providing the dosing port 8 and the sealing cap 4, it is convenient to add medicine to the container bottle 1, thus improving its practicality.

[0054] To facilitate sealing the dispensing section when not in use; such as Figure 2 , Figure 3As shown, a top cap 6 is fitted onto the top of the nozzle 19, and a silicone body 20 is adhered to the inner wall of the top cap 6; the silicone body 20 is elastically deformed and connected to the outer wall of one end of the nozzle 19; by setting the top cap 6 and the silicone body 20, the nozzle 19 can be sealed when not in use to prevent the medicine from leaking out, thus improving its practicality.

[0055] In this embodiment, when the dispensing section is facing upwards, the user places their finger on the squeezing part 3 of the squeezing wall 2 and squeezes the two connecting rods 22 inwards. This deformation of the container bottle 1 reduces its internal volume. Because the gap between the delivery pipe 9 and the diaphragm 31 is smaller than the inner diameter of the delivery pipe 9, the liquid medicine in the container bottle 1 is transported upwards from the delivery pipe 9 under air pressure. Simultaneously, the diaphragm 31 deforms under air pressure, and some gas is discharged from the gap between the diaphragm 31 and the delivery pipe 9, assisting in the transport of the liquid medicine emerging from the top of the delivery pipe 9. The liquid medicine and gas are simultaneously output from the dispensing section, achieving a spraying effect. When the dispensing section is facing downwards, the liquid medicine gathers at the diaphragm 31 due to gravity. When the container bottle 1... When squeezed, the liquid medicine first enters the airflow channel and then flows out directly from the dispensing part in streams. This design provides two different drug delivery methods, enhancing the flexibility of use. In addition, when the user presses the connecting rod 22, it can apply an axial force to the rotating column 26. Due to the sliding fit between the ball 30 and the spiral groove 29, the rotating column 26 rotates, driving the stirring part to rotate and stir. The user can also rotate the threaded ring 7 to raise and lower it. With the deformation and stretching of the annular pleated part 15, the rotating ring 5 supports the raising and lowering of the annular protrusion 14, thereby changing the distance between the nozzle 19 and the delivery pipe 9, thus changing the shape of the sprayed medicine mist to meet different usage needs.

[0056] Example 2:

[0057] A device for applying medication to the nose, such as Figure 7 , Figure 8As shown, for easy placement when not in use, this embodiment makes the following improvements based on embodiment 1: the top of the delivery tube 9 is integrally provided with evenly distributed branched tubes 34, the top outer wall of the diaphragm 31 is provided with evenly distributed cross-shaped micro-holes 35, and the bottom end of the delivery tube 9 is bonded with a counterweight ball 32. The counterweight ball 32 has a hollow structure, and the outer wall of the counterweight ball 32 is provided with evenly distributed through holes 33. By setting multiple branched tubes 34 and cross-shaped micro-holes 35, the liquid medicine can be divided into multiple streams when it is delivered to the airflow channel. In addition, when the container bottle 1 is pressed, the internal pressure increases, which causes the cross-shaped micro-holes 35 to deform and expand, squeezing the airflow upward from the cross-shaped micro-holes 35 to assist in the delivery of multiple streams of liquid medicine and improve the atomization effect. By setting the counterweight ball 32 and other structures, the counterweight ball 32 can be used to fall naturally by gravity, thereby ensuring that one end of the delivery tube 9 is always in the liquid medicine, and the liquid medicine can be squeezed out better.

[0058] Example 3:

[0059] A topical nasal medication system includes the aforementioned medication application device, a topical nasal medication formulation, and a method for preparing the formulation, wherein the formulation includes the following components: seawater and purified water;

[0060] The formulation is divided into physiological solution formulation and high-concentration solution formulation based on the final sodium chloride concentration. The specific components of the physiological solution formulation are: 15-20% seawater, 80-85% purified water, with sodium chloride content controlled at 8.5-10.4 g / L, or even 9.5 g / L, pH value of 6.5-8.0, and density (20℃) of 0.996-1.082 g / ml.

[0061] The specific components of the high-concentration medicine formula are: 45-50% seawater, 50-55% purified water, sodium chloride content controlled at 21.50-24.50 g / L, or even 24.0 g / L, pH value of 6.5-8.5, and density (20℃) of 0.996-1.082 g / ml.

[0062] The preparation method includes the following steps:

[0063] S1: Purify and filter seawater raw materials and sterilize them;

[0064] S2: Purified water is obtained by using reverse osmosis (RO) to process pure water.

[0065] S3: Mix the purified water with the treated seawater in the specified proportion;

[0066] S4: Stir to mix the two thoroughly;

[0067] S5: Test and treat the mixed water to meet the standards before bottling;

[0068] S6: Obtain nasal drops.

[0069] The final nasal solution should have a Pb content of less than 0.03%, a total bacterial count (cfu / mL) of ≤100, and a total fungal count (cfu / mL) of ≤10.

[0070] The specific microbiological indicators are as follows:

[0071]

[0072]

[0073] By meeting the requirements for microbial indicators, a safe and reliable nasal spray was finally obtained.

[0074] experiment:

[0075] I. To verify the drug delivery effect of this device, the following comparative experiment was conducted:

[0076] Experimental example: The drug application device proposed in this invention was used for drug application;

[0077] Comparative example: Using a commonly used pressure spraying device for spraying and applying pesticides;

[0078] The results were evaluated, and the following data was obtained:

[0079] Adopted scheme Experimental Example Comparison Example Effect of applying medicine 93 72 Treatment effect 91 77

[0080] As can be seen from the above, the application device proposed in this invention can assist in stirring and mixing the medicine during application, resulting in a more uniform mist-like medicine. Its application and therapeutic effects are significantly better than those of general pressure spraying devices.

[0081] II. To verify the therapeutic effect of nasal drops prepared with a physiological solution formula and to achieve the optimal ratio, the following comparative experiment was conducted:

[0082] By keeping other conditions constant and varying the proportion of seawater, a clinical trial was conducted on the prepared nasal spray, yielding the following data:

[0083] seawater percentage 15％ 16％ 17％ 18％ 19％ 20％ Flushing treatment effect 72.7 80.2 86.9 91.3 87.4 81.6

[0084] As can be seen from the above, the proportion of seawater in the physiological medicated solution formula is related to the effect of the rinsing treatment. The effect is best when the proportion of seawater is 18%. Therefore, the ingredients in the physiological medicated solution formula should be: 18% seawater and 82% purified water.

[0085] III. To verify the therapeutic effect of nasal drops prepared with a high-concentration formulation and to achieve the optimal ratio, the following comparative experiment was conducted:

[0086] By keeping other conditions constant and varying the proportion of seawater, a clinical trial was conducted on the prepared nasal spray, yielding the following data:

[0087] seawater percentage 45％ 46％ 47％ 48％ 49％ 50％ Osmotic therapy effect 88.4 90.8 89.2 84.6 78.1 70.2

[0088] As can be seen from the above, the proportion of seawater in the high-concentration medicine formula is related to the effect of osmotic therapy. The effect is best when the proportion of seawater is 46%. Therefore, the ingredients in the physiological medicine formula should be: 46% seawater and 54% purified water.

[0089] IV. To verify the optimal drug delivery effect of this device, the following comparative experiment was conducted:

[0090] By keeping other conditions constant, the atomization effect of the drug solution was altered by changing the inner diameter of the bifurcation tube 34. Clinical trials were conducted, and the following data were obtained:

[0091]

[0092]

[0093] As can be seen from the above, changing the inner diameter of the bifurcation tube alters the atomization effect, resulting in variations in the size of the sprayed drug mist. The therapeutic effect of the sprayed drug mist is optimal when the inner diameter of the bifurcation tube is 0.4 mm. Therefore, the inner diameter of the bifurcation tube should be controlled at 0.4 mm.

[0094] The above description represents a preferred embodiment of the present invention, but it is not the only specific embodiment of the present invention. The scope of protection of the present invention is not limited thereto. Any equivalent or equivalent substitutions or changes made by those skilled in the art within the scope of the technology disclosed in the present invention, in combination with existing technology or common knowledge, based on the technical solution and inventive concept of the present invention, should be covered within the scope of protection of the present invention.

Claims

1. A nasal topical medication application device, comprising a receiving bottle, Its features are, The container has a dispensing section at the top. A delivery pipe is fixed to the inner walls of both sides of the top of the container via a fixed bracket. The delivery pipe is located at the center of the inner side of the dispensing section. An airflow channel is provided between the delivery pipe and the dispensing section. A diaphragm is installed within the airflow channel. The delivery pipe is slidably connected to the inner wall of the diaphragm. The bottom end of the delivery pipe is located at the bottom of the container. An agitation mechanism is installed inside the container. The agitation mechanism includes a fixed sleeve, a rotating column, and an agitating part. The fixed sleeve is horizontally fixed to the center of the container via a fixed bracket. The outer circumference of the rotating column has circumferentially distributed spiral grooves. A sliding ball adapted to the spiral grooves is installed on the inner wall of one end of the fixed sleeve, and the sliding ball is slidably connected within the spiral grooves. The agitating part is located at the end of the rotating column away from the fixed sleeve. A connecting part is connected to the inner wall of one end of the rotating column. The connecting part includes a connecting rod and a first limiting head. The first limiting head is rotatably connected to the inner wall of one end of the rotating column. The connecting rod is located on the outer wall of one side of the first limiting head. Extrusion parts are provided on the extrusion walls on both sides of the container. One end of the connecting rod is fixed to the extrusion part. The dispensing section includes a nozzle and an annular pleated section. The annular pleated section is bonded between the outer wall of the top of the container bottle and the outer wall of the bottom of the nozzle. The annular pleated section is made of elastic silicone material. An annular protrusion is provided on the side wall of the bottom of the nozzle. A rotating ring is rotatably connected between two annular protrusions. A threaded ring is fixed to the bottom of the rotating ring through a connecting post. An annular threaded seat is provided on the outer wall of the top of the container bottle. The threaded ring is installed on the outer wall of the annular threaded seat in an adjustable manner through threads. A spring is fixed to one end of the rotating column. The spring is installed inside the fixed sleeve. A guide rod is fixed to the inner wall of the fixed sleeve. A second limit head is provided at one end of the guide rod. The second limit head is slidably connected to the inner wall of the rotating column. The top of the delivery tube is integrally equipped with evenly distributed branched tubes, and the top outer wall of the diaphragm has evenly distributed cross-shaped micropores. A counterweight ball is attached to the bottom of the delivery tube. The counterweight ball has a hollow structure, and its outer wall has evenly distributed through holes. By setting multiple branched tubes and cross-shaped micropores, the liquid medicine can be divided into multiple streams when it is delivered to the airflow channel. When the container bottle is pressed, the internal pressure increases, which causes the cross-shaped micropores to deform and expand, squeezing the airflow upward from the cross-shaped micropores to assist in the delivery of multiple streams of liquid medicine and improve the atomization effect.

Images