A communication device and a cell capturing and staining instrument thereof

Abstract

The application relates to a communication device and a cell capture dyeing instrument thereof, which comprises a frame and a placing seat for placing a to-be-communicated member, the placing seat is slidably connected to the frame, the frame is provided with a first driving mechanism capable of driving the placing seat to slide out of or into the frame; the frame is movably provided with a moving plate, the moving plate is provided with a sample outlet butt joint, and the frame is provided with a second driving mechanism capable of driving the moving plate to drive the sample outlet butt joint to be butt-jointed and communicated with a sample inlet of the to-be-communicated member in the frame. The application has the effect of improving butt-joint communication efficiency of the to-be-communicated member.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of biological detection equipment, in particular to a communication device and a cell capture and dyeing instrument. BACKGROUND

[0002] Microfluidic chip, also known as micro total analysis system or chip laboratory, is a process that combines sample preparation, biological and chemical reactions, separation and detection in the fields of chemistry, biology, etc.

[0003] The microfluidic chip generally includes a substrate and a structure, the substrate is usually glass and silicon wafer material, and the structure part is a micron level fluid channel, i.e. micro channel, built by high polymer material (such as PDMS, PMMA, PC, etc.). Due to the high hydrophobicity of the surface of the microfluidic chip, effective surface modification is needed to make it have reactive functional groups and affinity ligands, which determines the function and application field of the microfluidic chip. After the modified chip is used for sample analysis in the fields of chemistry, biology, medicine, etc., the target object often needs to be dyed and identified after being retained in the chip to analyze the measured object. Uniform and efficient dyeing is very important for accurate judgment of the sample.

[0004] For example, the communication component such as microfluidic chip is usually injected into the micro channel of the microfluidic chip from the sample inlet of the microfluidic chip by the injection pump mechanism during the preparation process. The communication mode between the existing injection pump mechanism and the sample inlet of the microfluidic chip is usually manual docking communication, so there is a defect of low docking efficiency, and therefore needs to be improved. SUMMARY

[0005] In order to improve the docking efficiency of the communication component, in the first aspect, the application provides a communication device.

[0006] The communication device provided by the application adopts the following technical scheme: a communication device, comprising a frame and a placing seat for placing a communication component, the placing seat is slidingly connected to the frame, the frame is provided with a first driving mechanism capable of driving the placing seat to slide out of or into the frame;

[0007] The frame movably provides a moving plate, the moving plate is provided with a sample outlet docking head, and the frame is provided with a second driving mechanism capable of driving the moving plate to drive the sample outlet docking head to dock and communicate with the sample inlet of the communication component in the frame.

[0008] By adopting the above technical scheme, the communication component is placed on the placing seat, the placing seat is driven by the first driving mechanism to drive the communication component to slide into the frame, and the second driving mechanism drives the moving plate to drive the sample outlet docking head to dock with the sample inlet of the communication component. Compared with manual docking and communication of the communication component, the docking and communication efficiency of the communication component is greatly improved.

[0009] Preferably, the placing seat is provided with at least one accommodating groove for accommodating the to-be-connected component, and the sample inlet of the to-be-connected component is arranged opposite to the sample outlet adapter.

[0010] By using the above technical scheme, the to-be-connected component is placed in the accommodating groove, and the to-be-connected component is limited by the accommodating groove, the sample inlet of the to-be-connected component is arranged opposite to the sample outlet adapter, and the sample outlet adapter is driven by the second driving mechanism to drive the moving plate to abut against the sample inlet of the to-be-connected component in a straight line direction, so that the sample outlet adapter and the sample inlet of the to-be-connected component are accurately butted, and in addition, the gas generated in the to-be-connected component due to lateral extrusion can be reduced, so as to affect the quality of the to-be-connected component.

[0011] Preferably, the to-be-connected component is limited in the accommodating groove by an inner wall of the frame, the placing seat is provided with a clearance opening communicating with the accommodating groove, and the sample outlet adapter passes through the clearance opening to abut against the sample inlet of the to-be-connected component.

[0012] By using the above technical scheme, the to-be-connected component is limited by the accommodating groove and the inner wall of the frame, so as to improve the stability of the communication between the sample outlet adapter and the to-be-connected component.

[0013] Preferably, the first driving mechanism comprises a first motor and a first screw rod, the first motor is installed on one side of the frame, the first screw rod is coaxially and fixedly arranged with an output shaft of the first motor, the first screw rod is in threaded connection with the placing seat, the placing seat is in sliding connection with the frame through a first linear guide rail, and the first linear guide rail is arranged in parallel with the first screw rod.

[0014] By using the above technical scheme, the first motor drives the first screw rod to rotate, so as to drive the placing seat in threaded connection with the first screw rod to slide out of or into the frame through the first linear guide rail, thereby facilitating the taking and placing of the to-be-connected component.

[0015] Preferably, the second driving mechanism comprises a second motor and a second screw rod, the second motor is installed on the frame, the second screw rod is coaxially and fixedly arranged with an output shaft of the second motor, the second screw rod drives the moving plate to move close to or away from the placing seat, and the moving plate is in sliding connection with the frame through a second linear guide rail.

[0016] By using the above technical scheme, the second motor drives the moving plate to move along the second linear guide rail through the second screw rod, so as to improve the stability of the abutment between the sample outlet adapter on the moving plate and the sample inlet of the to-be-connected component.

[0017] Preferably, the second driving mechanism further comprises a cross arm vertically arranged in the frame, and the cross arm is driven to rotate by the second motor and the second screw rod to push the moving plate to move up and down.

[0018] By adopting the technical scheme, the second motor drives the cross arm installed in the frame to rotate through the second screw rod, so as to drive the moving plate to move up and down, thereby reducing the installation space in the moving direction of the moving plate.

[0019] Preferably, the side wall of the sample outlet adapter is provided with a limiting portion, the moving plate is fixed with a mounting plate, the moving plate and the mounting plate are provided with a mounting hole in the corresponding position, the sample outlet adapter extends out of the moving plate through the mounting hole, the peripheral side wall of the mounting hole at the connecting position of the moving plate and the mounting plate is provided with a limiting groove, and the limiting portion is located in the limiting groove.

[0020] By adopting the technical scheme, the limiting portion on the side wall of the sample outlet adapter is installed in the limiting groove at the connecting position of the moving plate and the mounting plate, thereby improving the stability of the sample outlet adapter installed on the moving plate.

[0021] Preferably, gaps exist between the sample outlet adapter and the mounting hole and between the limiting portion and the limiting groove.

[0022] By adopting the technical scheme, gaps are provided between the sample outlet adapter and the mounting hole and between the limiting portion and the limiting groove, so that when there is a slight misalignment between the sample inlet hole and the sample outlet adapter, the sample inlet hole and the sample outlet adapter can be accurately connected and communicated.

[0023] Preferably, a plurality of accommodation grooves are provided, the plurality of accommodation grooves are arranged at intervals on the upper surface of the placing seat, and the upper surface of the placing seat on both sides of the accommodation groove is provided with a downwardly recessed film taking groove.

[0024] By adopting the technical scheme, a plurality of accommodation grooves are provided, so that the butt joint and communication of the to-be-connected components can be batched.

[0025] Preferably, the upper surface of the frame is provided with an observation port corresponding to the accommodation groove.

[0026] By adopting the technical scheme, the observation port on the frame facilitates the observation of the to-be-connected components in the accommodation groove.

[0027] Preferably, the to-be-connected component is a microfluidic chip.

[0028] By adopting the technical scheme, the microfluidic chip is placed on the placing seat, the placing seat is driven by the first driving mechanism to drive the microfluidic chip to slide into the frame, and the second driving mechanism drives the moving plate to drive the sample outlet adapter to butt joint with the sample inlet hole of the microfluidic chip. Compared with manual butt joint and communication, the efficiency of the butt joint and communication of the microfluidic chip is greatly improved.

[0029] Preferably, the bottom of the moving plate is provided with a waste liquid collecting hopper, the moving plate is provided with a communication hole corresponding to the liquid outlet hole of the microfluidic chip, the communication hole is in communication with the waste liquid collecting hopper, the moving plate is provided with a liquid collecting hole, the liquid collecting hole is in communication with the waste liquid collecting hopper, and the upper surface of the moving plate is gradually inclined downward to the liquid collecting hole.

[0030] By adopting the above technical scheme, when the sample outlet connector is not connected with the microfluidic chip, the waste liquid discharged by the sample outlet connector flows into the waste liquid collecting hopper through the liquid collecting hole on the moving plate, and when the sample outlet connector is connected with the microfluidic chip, the liquid outlet hole is in communication with the communication hole, so that the waste liquid generated during the cleaning of the internal channel of the microfluidic chip can be conveniently collected in the waste liquid collecting hopper.

[0031] Preferably, the waste liquid collecting hopper is in communication with a waste liquid tank, the waste liquid tank is connected with a waste liquid pump through a pipeline, the waste liquid tank is provided with a liquid level sensor, and the liquid level sensor controls the operation of the waste liquid pump through a controller.

[0032] By adopting the above technical scheme, when the liquid level sensor detects that there is too much waste liquid in the waste liquid tank, the controller controls the operation of the waste liquid pump to pump out the waste liquid in the waste liquid tank.

[0033] In a second aspect, the present application provides a cell capture staining instrument.

[0034] The cell capture staining instrument provided by the present application adopts the following technical scheme:

[0035] The cell capture staining instrument provided by the present application adopts the following technical scheme:

[0036] By adopting the above technical scheme, the to-be-connected component is placed on the placement seat, the first driving mechanism drives the placement seat to drive the to-be-connected component to slide into the frame, and the second driving mechanism drives the moving plate to drive the sample outlet connector to be connected with the sample inlet hole of the to-be-connected component, so that the efficiency of connecting the to-be-connected component is greatly improved compared with manual connection. And the sample is injected into the to-be-connected component by the injection pump mechanism for preparation, thereby improving the preparation efficiency of the to-be-connected component.

[0037] Preferably, the shell is provided with an information identifier for identifying the label information on the to-be-connected component, and the information identifier controls the operation of the injection pump mechanism through a controller.

[0038] By adopting the above technical scheme, the information identifier identifies the label information on the to-be-connected component, so that the injection pump mechanism injects the corresponding sample into the corresponding to-be-connected component, thereby improving the accuracy of the preparation of the to-be-connected component.

[0039] Preferably, a driving assembly for driving the information identifier to sequentially identify information of the plurality of to-be-connected components is arranged in the shell.

[0040] The driving assembly comprises a mounting bracket, a third motor, a third screw rod and a mounting seat, the mounting bracket is fixed in the shell, the third motor is mounted on one side of the mounting bracket, the third screw rod is rotatably connected to the mounting bracket, the output shaft of the third motor is coaxially fixedly connected with the third screw rod, the mounting seat is threadedly connected with the third screw rod and slidably connected with the mounting bracket through a third linear guide rail, the information identifier is mounted on the mounting seat, the information identifier faces label information of the to-be-connected component, and the label information is located at the observation port.

[0041] By adopting the above technical scheme, the third motor drives the third screw rod to drive the mounting seat to move along the linear guide rail, so that the information of the to-be-connected component placed in the plurality of accommodating grooves is identified, and the identification efficiency is improved. BRIEF DESCRIPTION OF DRAWINGS

[0042] Figure 1 It is a schematic diagram of the overall structure of the connecting device in the embodiment of the application.

[0043] Figure 2 It is a schematic diagram of the overall structure of the connecting device in the embodiment of the application.

[0044] Figure 3 It is a schematic diagram of the structure inside the frame in the embodiment of the application.

[0045] Figure 4 It is a schematic diagram of the mounting structure of the moving plate and the second driving mechanism in the frame in the embodiment of the application.

[0046] Figure 5 It is a schematic diagram of the structure of the moving plate and the second driving mechanism in the frame in the embodiment of the application.

[0047] Figure 6 It is a top view of the moving plate in the embodiment of the application.

[0048] Figure 7 It is Figure 6 a sectional view of A-A in FIG.

[0049] Figure 8 It is an exploded structural schematic diagram of the bottom of the moving plate and the waste liquid collecting hopper in the embodiment of the application.

[0050] Figure 9 It is a schematic diagram of the overall structure of the cell capture and staining instrument in the embodiment of the application.

[0051] Figure 10 It is a schematic diagram of the mounting structure of the connecting device and the information identifier in the embodiment of the application.

[0052] Figure 11 This is a schematic diagram of the installation structure of the information recognizer and driver components of this application.

[0053] Explanation of reference numerals in the attached drawings: 1. Frame; 11. Base plate; 111. Window; 12. Top plate; 121. Observation port; 13. First infrared sensor; 14. Wheel seat; 141. Roller; 15. Vertical plate; 16. Connecting plate; 161. Second lug; 2. Placement seat; 21. Microfluidic chip; 22. Receiving groove; 221. Clearance opening; 23. Sample picking groove; 24. Connecting block; 25. Clearance channel; 26. Mounting block; 27. First trigger element; 3. First drive mechanism; 31. First motor; 32. First lead screw; 33. First linear guide rail; 4. Moving plate; 41. Sample ejection connector; 411. Limiting part; 42. First lug; 43. 44. Vertical block; 45. Guide block; 46. Mounting plate; 47. Mounting hole; 48. Limiting groove; 49. Sealing ring; 40. Connecting hole; 51. Liquid collection hole; 52. Second drive mechanism; 53. Second motor; 54. Second lead screw; 55. Second linear guide rail; 56. Cross arm; 57. First arm; 58. Second arm; 59. Push block; 50. Moving block; 61. Waste liquid collection hopper; 62. Waste liquid tank; 73. Liquid level sensor; 74. Housing; 75. Sliding cover; 8. Information identifier; 96. Drive assembly; 97. Mounting bracket; 98. Third motor; 99. Third lead screw; 90. Mounting base; 91. Third linear guide rail. Detailed Implementation

[0054] The following is in conjunction with the appendix Figures 1-11 This application will be described in further detail.

[0055] This application discloses a communication device. (Refer to...) Figure 1 and Figure 2 The system includes a frame 1 and a placement seat 2 for placing the component to be connected. The placement seat 2 is slidably connected to the frame 1. The frame 1 is provided with a first driving mechanism 3 capable of driving the placement seat 2 to slide out or slide into the frame 1. The frame 1 includes a base plate 11 and a top plate 12. The lower surface of the top plate 12 protrudes downward on both sides and is fixedly connected to the base plate 11 by screws to form a space for accommodating the placement seat 2. In this embodiment, the component to be connected is a microfluidic chip 21. In other embodiments, the component to be connected can be a sample carrier for injecting samples into internal channels.

[0056] Preferred, refer to Figure 2The upper surface of the placement seat 2 is provided with at least one accommodation groove 22 for accommodating the to-be-connected component. In the embodiment, four accommodation grooves 22 are provided, and the four accommodation grooves 22 are arranged at intervals along the upper surface of the placement seat 2. The upper surface of the placement seat 2 located on both sides of the accommodation groove 22 is provided with a downwardly recessed piece-taking groove 23. The upper surface of the top plate 12 is provided with an observation port 121 corresponding to the accommodation groove 22, and the to-be-connected component in the accommodation groove 22 is observed through the observation port 121. The microfluidic chip 21 is limited in the accommodation groove 22 by an inner wall of the frame 1. Specifically, the microfluidic chip 21 is stably located in the accommodation groove 22 by limiting the lower surface of the top plate 12.

[0057] With reference to Figure 3 The first driving mechanism 3 includes a first motor 31 and a first lead screw 32. The first motor 31 is installed on one side of the frame 1, and the first lead screw 32 is coaxially fixed with the output shaft of the first motor 31. The first lead screw 32 is threadedly connected with the placement seat 2. Specifically, a connecting block 24 is fixedly arranged on one side of the placement seat 2 and threadedly connected with the first lead screw 32. The placement seat 2 is provided with a letting-channel 25 for the first lead screw 32 to movably pass through. The placement seat 2 is slidably connected with the frame 1 through a first linear guide rail 33, and the first linear guide rail 33 is parallel to the first lead screw 32. Two first linear guide rails 33 are arranged on the bottom plate 11 located on both sides of the placement seat 2. The placement seat 2 is integrally provided with a mounting block 26 outwardly on both sides. The first guide rail of the first linear guide rail 33 is fixedly installed on the bottom plate 11, and the first sliding block of the first linear guide rail 33 is fixedly installed on the lower surface of the mounting block 26. A first infrared sensor 13 is arranged on one side of the bottom plate 11, and a first trigger 27 is arranged on the placement seat 2. The first lead screw 32 is driven by the first motor 31 to make the placement seat 2 slide into the frame 1, and at the same time, the first trigger 27 triggers the first infrared sensor 13 to send an induction signal. The induction signal of the first infrared sensor 13 controls the first motor 31 to stop working through the controller, so that the placement seat 2 is located at a set position in the frame 1.

[0058] With reference to Figure 3 and Figure 4 Two wheel seats 14 are fixedly arranged on the front side of the bottom plate 11 along the length direction, and a roller 141 is rotatably connected to the wheel seat 14. The lower surface of the placement seat 2 is in contact with the wheel surface of the roller 141. The frame 1 movably provides a moving plate 4, and the moving plate 4 is provided with a sample-out butt joint 41. The bottom plate 11 is provided with a window 111 for the moving plate 4 to move through. The frame 1 is provided with a second driving mechanism 5 capable of driving the moving plate 4 to drive the sample-out butt joint 41 to be in butt joint and communication with the sample inlet of the microfluidic chip 21 in the frame 1. The second driving mechanism 5 drives the moving plate 4 to drive the sample-out butt joint 41 to be in butt joint with the sample inlet of the microfluidic chip 21, which greatly improves the efficiency of butt joint and communication of the microfluidic chip 21 compared with manual butt joint and communication of the microfluidic chip 21.

[0059] With reference to Figure 3 and Figure 4 , the accommodation groove 22 is provided with a clearance 221 communicated with the outside, and the sample outlet adapter 41 passes through the clearance 221 and is connected with the sample inlet hole of the microfluidic chip 21 through the second driving mechanism 5. The sample inlet hole of the microfluidic chip 21 is arranged opposite to the sample outlet adapter 41 in the embodiment. The microfluidic chip 21 is placed in the accommodation groove 22, and the microfluidic chip 21 is limited by the accommodation groove 22. The sample inlet hole of the microfluidic chip 21 is opposite to the sample outlet adapter 41. The second driving mechanism 5 drives the moving plate 4 to drive the sample outlet adapter 41 to be connected with the sample inlet hole of the microfluidic chip 21 in a straight line direction, so as to improve the accurate connection between the sample outlet adapter 41 and the sample inlet hole of the microfluidic chip 21. In addition, the sample outlet adapter 41 and the sample inlet hole of the microfluidic chip 21 are prevented from being laterally extruded, so as to prevent gas from entering the microfluidic chip 21, thereby affecting the quality of the microfluidic chip 21.

[0060] With reference to Figure 4 and Figure 5 , the second driving mechanism 5 comprises a second motor 51 and a second screw rod 52. The second motor 51 is installed on the frame 1. Specifically, the frame 1 further comprises two vertical plates 15 vertically and spacedly fixedly installed on the lower surface of the bottom plate 11, and the second motor 51 is fixedly installed on the side wall of one of the vertical plates 15. The second screw rod 52 is coaxially and fixedly arranged with the output shaft of the second motor 51. The second screw rod 52 drives the moving plate 4 to move close to or away from the placing seat 2. The moving plate 4 is slidably connected with the frame 1 through a second linear guide rail 53. Two second linear guide rails 53 are arranged. The second guide rails of the two second linear guide rails 53 are vertically installed on the opposite side walls of the two vertical plates 15, respectively. The second sliding blocks of the two second linear guide rails 53 are fixedly arranged on the side walls of the moving plate 4, respectively. The second guide rails are perpendicular to the second screw rod 52. The second motor 51 drives the moving plate 4 to move along the second guide rails through the second screw rod 52, so as to improve the stability of the connection between the sample outlet adapter 41 on the moving plate 4 and the sample inlet hole of the to-be-connected component.

[0061] With reference to Figure 5 and Figure 8The second driving mechanism 5 further comprises a cross arm 54 vertically arranged in the frame 1, which is driven to rotate by the second motor 51 and the second screw rod 52 to push the moving plate 4 to move up and down. The second motor 51 drives the cross arm 54 arranged in the frame 1 to rotate through the second screw rod 52, thereby pushing the moving plate 4 to move up and down, so as to reduce the installation space in the moving direction of the moving plate 4. Specifically, the connecting plate 16 is fixed between the two vertical plates 15, and the cross arm 54 is arranged between the connecting plate 16 and the moving plate 4. The cross arm 54 comprises a first arm rod 541 and a second arm rod 542, which are cross-rotatably connected. The surface of the moving plate 4 is fixedly provided with a first lug 42, one end of the first arm rod 541 is hingedly connected with the first lug 42, the second screw rod 52 is threadedly connected with a pushing block 543, and the other end of the first arm rod 541 is hingedly connected with the pushing block 543. The connecting plate 16 is fixedly provided with a second lug 161, the first lug 42 and the second lug 161 are oppositely arranged, one end of the second arm rod 542 is hingedly connected with the second lug 161, the moving plate 4 is slidingly connected with a moving block 544 opposite to the pushing block 543, and the other end of the second arm rod 542 is hingedly connected with the moving block 544. Specifically, two vertical blocks 43 are fixedly arranged on the lower surface of the moving plate 4 along the moving direction of the moving block 544, and a guide block 44 is fixedly connected between the two vertical blocks 43. The guide block 44 is arranged in parallel with the moving plate 4, and the moving block 544 is slidingly connected between the guide block 44 and the moving plate 4.

[0062] With reference to Figure 6 and Figure 7 Two sample outlet adapters 41 are arranged corresponding to one microfluidic chip 21, and the two sample outlet adapters 41 are arranged corresponding to two sample inlet holes of the microfluidic chip 21. The side wall of the sample outlet adapter 41 is provided with a limiting portion 411, the moving plate 4 is fixedly provided with a mounting plate 45, and the moving plate 4 and the mounting plate 45 are provided with a mounting hole 46 in communication at the corresponding positions. The sample outlet adapter 41 extends out of the moving plate 4 through the mounting hole 46, the circumferential side wall of the mounting hole 46 at the connecting position of the moving plate 4 and the mounting plate 45 is provided with a limiting groove 461, the limiting portion 411 is located in the limiting groove 461, and the mounting plate 45 is divided into two parts along the axis direction of the mounting hole 46. There is a gap between the sample outlet adapter 41 and the mounting hole 46, and between the limiting portion 411 and the limiting groove 461. Therefore, when there is a slight misalignment between the sample inlet hole and the sample outlet adapter 41, the sample inlet hole and the sample outlet adapter 41 can be accurately connected and communicated. A sealing ring 47 is sleeved on the sample outlet adapter 41, and the sealing ring 47 is located on the surface of the moving plate 4.

[0063] With reference to Figure 6 and Figure 8The bottom of the moving plate 4 is provided with a waste liquid collecting hopper 6. The moving plate 4 is provided with a communication hole 48 corresponding to the liquid outlet hole of the microfluidic chip 21. The communication hole 48 is in communication with the waste liquid collecting hopper 6. The moving plate 4 is provided with a liquid collecting hole 49. The liquid collecting hole 49 is in communication with the waste liquid collecting hopper 6. The upper surface of the moving plate 4 is gradually inclined downward to the liquid collecting hole 49. When the sample outlet connector 41 is separated from the sample inlet hole of the microfluidic chip 21, the waste liquid discharged by the sample outlet connector 41 flows into the waste liquid collecting hopper 6 through the liquid collecting hole 49 on the moving plate 4. When the sample outlet connector 41 is connected to the microfluidic chip 21, the liquid outlet hole is in communication with the communication hole 48. Therefore, the waste liquid for cleaning the internal channel of the microfluidic chip 21 can be conveniently collected in the waste liquid collecting hopper 6.

[0064] With reference to Figure 3 and Figure 8 The waste liquid collecting hopper 6 is in communication with a waste liquid tank 61. The waste liquid tank 61 is connected with a waste liquid pump (not shown in the figure) through a pipeline. The waste liquid tank 61 is provided with a liquid level sensor 62. The liquid level sensor 62 controls the operation of the waste liquid pump through a controller. When the liquid level sensor 62 detects that the waste liquid in the waste liquid tank 61 is too much, the waste liquid in the waste liquid tank 61 is pumped out through the controller.

[0065] The implementation principle of the communication device in the embodiment of the application is that the microfluidic chip 21 is placed in the accommodating groove 22 of the placing seat 2. The placing seat 2 is driven into the frame 1 by the first driving mechanism 3. Then the moving plate 4 is driven by the second driving mechanism 5 to drive the sample outlet connector 41 to be connected to the sample inlet hole of the microfluidic chip 21. Compared with manual connection, the efficiency of connecting the microfluidic chip 21 is greatly improved.

[0066] The embodiment also discloses a cell capture and dyeing instrument. With reference to Figure 9 , the communication device is mounted on the shell 7. The sample inlet end of the sample outlet connector 41 is in communication with the injection pump mechanism in the shell 7 through a pipeline.

[0067] With reference to Figure 9 and Figure 10 The shell 7 is slidably provided with a sliding cover 71 covering the communication device. The sliding cover 71 is provided with an information identifier 8 for identifying the label information on the microfluidic chip 21. The information identifier 8 controls the operation of the injection pump mechanism through a controller. The label information in the embodiment is a bar code information label. The information identifier 8 is a bar code scanner. The information identifier 8 identifies the label information on the microfluidic chip 21, so that the injection pump mechanism injects the corresponding sample into the corresponding microfluidic chip 21, thereby improving the accuracy of the preparation of the microfluidic chip 21.

[0068] With reference to Figure 9 and Figure 11The driving assembly 9 is arranged in the sliding cover 71 and is used for driving the information identifier 8 to sequentially identify information of the plurality of micro-fluidic chips 21. The driving assembly 9 comprises a mounting bracket 91, a third motor 92, a third screw rod 93 and a mounting seat 94. The mounting bracket 91 is fixed in the shell 7. The third motor 92 is mounted on one side of the mounting bracket 91. The third screw rod 93 is rotationally connected to the mounting bracket 91. The output shaft of the third motor 92 is coaxially and fixedly connected with the third screw rod 93. The mounting seat 94 is threadedly connected with the third screw rod 93 and is slidably connected with the mounting bracket 91 through a third linear guide rail 95. The third guide rail of the third linear guide rail 95 is fixedly mounted on the mounting bracket 91 and is arranged in parallel with the third screw rod 93. The third sliding block of the third linear guide rail 95 is fixedly mounted on the mounting seat 94. The information identifier 8 is mounted on the mounting seat 94 and faces the label information of the micro-fluidic chip 21. The label information is located at the observation port 121. The third motor 92 drives the third screw rod 93 to drive the mounting seat 94 to move along the third linear guide rail 95, so as to identify information of the to-be-connected components placed in the plurality of accommodating grooves 22, thereby improving the identification efficiency.

[0069] The implementation principle of the cell capture staining instrument is as follows: the micro-fluidic chip 21 is placed in the accommodating groove 22 of the placing seat 2. The placing seat 2 is driven into the frame 1 by the first driving mechanism 3. The pipeline is cleaned by the injection pump mechanism. Then the liquid collected through the liquid collecting hole 49 arranged on the moving plate 4 flows into the waste liquid collecting bucket 6. Then the second driving mechanism 5 is automatically controlled by the controller to drive the sample outlet joint 41 on the moving plate 4 to be connected with the sample inlet hole of the micro-fluidic chip 21. The internal channel of the micro-fluidic chip 21 is cleaned by the injection pump mechanism. Then the waste liquid is discharged into the waste liquid collecting bucket 6 through the communication hole 48 connected with the liquid outlet hole. After the micro-fluidic chip 21 is cleaned, the sample collected by the injection pump mechanism is injected into the internal channel of the micro-fluidic chip 21 to prepare the sample, thereby improving the sample preparation efficiency of the micro-fluidic chip 21.

[0070] The above are preferred embodiments of the present application, and do not limit the protection scope of the present application. Therefore, equivalent changes made on the basis of the structure, shape and principle of the present application should be covered within the protection scope of the present application.

Claims

1. A communication device, characterized by: The frame (1) is provided with a first driving mechanism (3) capable of driving the placement seat (2) to slide out or slide into the frame (1); the frame (1) is movably provided with a moving plate (4), the moving plate (4) is provided with a sample outlet butt joint (41), a second driving mechanism (5) comprises a second motor (51) and a second screw rod (52), the second motor (51) is mounted on the frame (1), the second screw rod (52) is coaxially fixed with the output shaft of the second motor (51), the second screw rod (52) drives the moving plate (4) to be close to or away from the placement seat (2), and the moving plate (4) is slidably connected with the frame (1) through a second linear guide rail (53); the second driving mechanism (5) further comprises a cross arm (54) vertically arranged in the frame (1), the cross arm (54) is driven to rotate by the second motor (51) and the second screw rod (52) to push the moving plate (4) to move up and down; the frame (1) is provided with a second driving mechanism (5) capable of driving the moving plate (4) to drive the sample outlet butt joint (41) to be in butt joint communication with the sample inlet of the microfluidic chip (21) in the frame (1); the placement seat (2) is provided with at least one accommodation groove (22) for accommodating the microfluidic chip (21), and the sample inlet of the microfluidic chip (21) is arranged opposite to the sample outlet butt joint (41); the microfluidic chip (21) is limited in the accommodation groove (22) through an inner wall of the frame (1), the placement seat (2) is provided with a gap (221) in communication with the accommodation groove (22), and the sample outlet butt joint (41) is opposite to the sample inlet of the microfluidic chip (21) through the gap (221) by the second driving mechanism (5); a limiting portion (411) is arranged on the side wall of the sample outlet butt joint (41), the moving plate (4) is fixed with a mounting plate (45), the moving plate (4) and the mounting plate (45) are provided with a mounting hole (46) in communication at the corresponding positions, the sample outlet butt joint (41) extends out of the moving plate (4) through the mounting hole (46), a limiting groove (461) is arranged on the circumferential wall of the mounting hole (46) at the connecting position of the moving plate (4) and the mounting plate (45), and the limiting portion (411) is located in the limiting groove (461); gaps exist between the sample outlet butt joint (41) and the mounting hole (46) and between the limiting portion (411) and the limiting groove (461). ​ The mobile plate (4) is provided with a waste liquid collecting hopper (6) at the bottom, the mobile plate (4) is provided with a communication hole (48) corresponding to the liquid outlet hole of the microfluidic chip (21), the communication hole (48) is communicated with the waste liquid collecting hopper (6), the mobile plate (4) is provided with a liquid collecting hole (49), the liquid collecting hole (49) is communicated with the waste liquid collecting hopper (6), and the upper surface edge of the mobile plate (4) is gradually inclined downward to the liquid collecting hole (49) direction; the waste liquid collecting hopper (6) is communicated with a waste liquid tank (61), the waste liquid tank (61) is connected with a waste liquid pump through a pipeline, the waste liquid tank (61) is provided with a liquid level sensor (62), and the liquid level sensor (62) controls the waste liquid pump to work through the controller.

2. A communication device according to claim 1, wherein: The first driving mechanism (3) comprises a first motor (31) and a first screw rod (32), the first motor (31) is installed on one side of the frame (1), the first screw rod (32) is coaxially fixed with the output shaft of the first motor (31), the first screw rod (32) is threadedly connected with the placing seat (2), the placing seat (2) is slidably connected with the frame (1) through the first linear guide rail (33), and the first linear guide rail (33) is arranged in parallel with the first screw rod (32).

3. A communication device according to claim 1, wherein: The accommodation grooves (22) are arranged in plurality, the accommodation grooves (22) are arranged at intervals on the upper surface of the placing seat (2), and the upper surface of the placing seat (2) on both sides of the accommodation groove (22) is provided with a downward recessed sample taking groove (23).

4. A communication device according to claim 3, wherein: The upper surface of the frame (1) is provided with an observation port (121) corresponding to the accommodation groove (22).

5. A cellular dye capture instrument, characterized by: The communication device and the shell (7) are connected, the communication device is installed on the shell (7), and the sample injection end of the sample butt joint (41) is communicated with the injection pump mechanism in the shell (7) through a pipeline.

6. A cell capture staining instrument according to claim 5, wherein: The shell (7) is provided with an information identifier (8) for identifying the label information on the to-be-connected component, and the information identifier (8) controls the injection pump mechanism to work through the controller.

7. A cell capture staining instrument according to claim 6, wherein: The shell (7) is provided with a driving assembly (9) for driving the information identifier (8) to identify the information of the plurality of to-be-connected components in sequence. The driving assembly (9) comprises a mounting bracket (91), a third motor (92), a third screw rod (93) and a mounting seat (94), the mounting bracket (91) is fixed in the shell (7), the third motor (92) is installed on one side of the mounting bracket (91), the third screw rod (93) is rotatably connected to the mounting bracket (91), the output shaft of the third motor (92) is coaxially fixedly connected with the third screw rod (93), the mounting seat (94) is threadedly connected with the third screw rod (93) and slidably connected with the mounting bracket (91) through the third linear guide rail (95), the information identifier (8) is installed on the mounting seat (94), the information identifier (8) faces the label information of the to-be-connected component, and the label information is located at the observation port (121).

Images