Needle mixing structure, automated detection equipment

By designing a needle mixing structure including a reagent needle, a support assembly and a power mechanism, and using vibration to drive reagent needle tremor to achieve high-frequency rotation and mixing of liquid, the problems of low mixing efficiency, overflow and cross-contamination in the prior art are solved, and rapid, effective and pollution-free liquid mixing is achieved.

CN114624090BActive Publication Date: 2025-05-27SUZHOU INST OF BIOMEDICAL ENG & TECH CHINESE ACADEMY OF SCI
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Patent Information

Application Number
CN202210311351.9
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2022-03-28
Publication Date
2025-05-27
Estimated Expiration
2042-03-28

AI Technical Summary

Technical Problem

In the prior art, the technique of combining sampling needles with uniform mixing has problems such as low mixing efficiency, sample overflow and cross-contamination, making it difficult to achieve rapid, effective and pollution-free liquid mixing.

Method used

A needle mixing structure is designed, including a reagent needle, a support assembly and a power mechanism. The power mechanism drives the reagent needle to shake through vibration, causing its tail to move at high frequency within the circumference to achieve rotation and mixing of the liquid.

Benefits of technology

During the liquid mixing process, only the reagent needles come into contact with the reaction liquid, which avoids the liquid loss caused by the additional stirring rod, helps the subsequent mechanism to accurately measure the number of particles in the liquid, and improves the mixing efficiency and safety.

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Abstract

The present invention relates to a needle mixing structure and an automated detection device. Among them, the needle mixing structure includes a mixing body; the mixing body includes: a reagent needle for storing liquid; a support assembly for supporting the reagent needle; a power mechanism for providing power for the movement of the reagent needle; the axis of the power device in the power mechanism is aligned with the axis of the reagent needle; when the power device is started, the power device vibrates, driving the reagent needle to tremble, so that the tail of the reagent needle moves at a high frequency within a certain circumferential range, so as to promote the rotation and mixing of the liquid in the reagent needle. During the mixing process of this needle mixing structure, only the reagent needle contacts the reaction liquid, avoiding liquid loss caused by an additional stirring rod, which helps the subsequent mechanism to accurately quantify the number of particles in the liquid.
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Description

Technical Field

[0001] The present invention relates to the technical field of automated equipment, and particularly relates to a needle mixing structure and an automated detection device.

Background Art

[0002] Analyzing biological samples, such as blood samples, is an important field of analysis. When analyzing the concentration parameters of such liquid samples, it is necessary to effectively mix the samples. In order to make the analysis results accurate and reproducible, fast and effective mixing means are applied to the sampling needles of analytical instruments.

[0003] Currently, the technologies for combining mixing with sampling needles mainly include the following: one is suction and discharge mixing. This mixing method requires controlling the timing, and the mixing efficiency is low; the second is bubble mixing. The disadvantage of this technology is that when the gas is discharged from the needle tip, the liquid level often rises, resulting in the phenomenon of sample overflowing from the test tube, causing pollution; the third is stirring mixing. This technology generally uses a separate stirring rod to extend into the sample for mixing, and then transports the sample to the sampling position for sampling. This technology requires the stirring rod and the sampling needle to process a sample separately, thus increasing the cleaning requirements and also increasing the cross-contamination link between samples.

[0004] Therefore, there is an urgent need to invent an effective needle mixing structure to solve the problems in the prior art.

Summary of the Invention

[0005] Aiming at the deficiencies of the prior art, the purpose of the present invention is to provide a needle mixing structure, including a mixing body; the mixing body includes:

[0006] A reagent needle for storing liquid;

[0007] A support assembly for supporting the reagent needle;

[0008] A power mechanism for providing power for the movement of the reagent needle;

[0009] The axis of the power device in the power mechanism is aligned with the axis of the reagent needle; when the power device is started, the power device vibrates, driving the reagent needle to vibrate, and further causing the tail of the reagent needle to move at a high frequency within a certain circumferential range, so as to promote the rotation and mixing of the liquid in the reagent needle.

[0010] Preferably, a liquid pipeline is provided in the reagent needle, and the outlet of the liquid pipeline is communicated with a sampling pump to take out the liquid in the liquid pipeline.

[0011] Preferably, the support assembly further includes a movable mechanism, which drives the reagent needle to vibrate when the power device is started, and drives the reagent needle to return to its original position when the power device is turned off.

[0012] Preferably, the movable mechanism includes a movable bottom plate and a plurality of damping members, and the plurality of damping members are arranged between the movable bottom plate and the bottom of the mixing body.

[0013] Preferably, the plurality of damping members are evenly distributed under the movable bottom plate.

[0014] Preferably, the power device is a vibration motor, and an eccentric block is installed on the main shaft of the vibration motor. After the vibration motor is powered on, the main shaft of the vibration motor drives the eccentric block to rotate, so as to drive the whole vibration motor to vibrate.

[0015] Preferably, it further includes a motor mounting seat, the motor mounting seat is fixedly connected to the support assembly, and the power device is fixedly connected to the motor mounting seat.

[0016] Preferably, the motor mounting seat is in the shape of a housing, and at least part of the power device is accommodated in the motor mounting seat.

[0017] Preferably, the motor mounting seat further includes a notch, and the position of the reagent needle can be adjusted through the notch.

[0018] The present invention also provides an automatic detection device, including a device body; the device body includes the needle mixing structure as described above.

[0019] Compared with the prior art, the beneficial effects of the present invention are as follows:

[0020] The present invention provides a needle mixing structure and an automatic detection device. Among them, the needle mixing structure includes a mixing body; the mixing body includes: a reagent needle for storing liquid; a support assembly for supporting the reagent needle; a power mechanism for providing power for the movement of the reagent needle; the axis of the power device in the power mechanism is aligned with the axis of the reagent needle; when the power device is started, the power device vibrates, driving the reagent needle to tremble, so that the tail of the reagent needle moves at a high frequency within a certain circumferential range, so as to promote the liquid in the reagent needle to rotate and mix. During the mixing process of this needle mixing structure, only the reagent needle contacts the reaction liquid, avoiding liquid loss caused by an additional stirring rod, which helps the subsequent mechanism to accurately quantify the number of particles in the liquid.

[0021] The above description is only an overview of the technical solution of the present invention. In order to better understand the technical means of the present invention and implement it according to the content of the specification, the following provides a detailed description of the preferred embodiments of the present invention in conjunction with the accompanying drawings. The specific implementation manners of the present invention are given in detail by the following embodiments and their accompanying drawings.

Description of the Drawings

[0022] The drawings described herein are used to provide a further understanding of the present invention and form a part of this application. The schematic embodiments of the present invention and their descriptions are used to explain the present invention and do not constitute an improper limitation to the present invention. In the drawings:

[0023] Figure 1 is a schematic structural diagram of the needle mixing structure of the present invention;

[0024] Figure 2 is a cross-sectional view of the needle mixing structure of the present invention.

[0025] Description of the reference numerals:

[0026] 10, mixing body;

[0027] 11, reagent needle; 12, eccentric block; 13, vibration motor; 14, movable bottom plate; 15, damping member; 16, mixing base; 17, motor mounting seat; 18, first accommodation hole; 19, second accommodation hole.

Specific Embodiment

[0028] The following further describes the present invention in detail with reference to the accompanying drawings. The foregoing and other objects, features, aspects and advantages of the present invention will become more apparent, so that those skilled in the art can implement it according to the description in the specification. In the drawings, for clarity, the shapes and dimensions may be enlarged, and the same reference numerals will be used throughout the drawings to indicate the same or similar components. In the following description, terms such as center, thickness, height, length, front, back, rear, left, right, top, bottom, upper, lower, etc. are based on the orientation or positional relationship shown in the drawings. In particular, "height" corresponds to the dimension from top to bottom, "width" corresponds to the dimension from left to right, and "depth" corresponds to the dimension from front to back. These relative terms are for convenience of description and generally do not intend to require a specific orientation. Terms related to attachment, connection, etc. (for example, "connect" and "attach") refer to the relationship in which these structures are directly or indirectly fixed or attached to each other through an intermediate structure, and the relationship of movable or rigid attachment or connection, unless otherwise explicitly stated.

[0029] Next, in combination with the accompanying drawings and specific embodiments, the present invention will be further described. It should be noted that, on the premise of no conflict, the following-described embodiments or technical features can be arbitrarily combined to form new embodiments. It should be understood that the terms such as "having", "comprising", and "including" used herein do not exclude the existence or addition of one or more other elements or their combinations.

[0030] Embodiment 1

[0031] A needle mixing structure includes a mixing body 10; the mixing body 10 includes:

[0032] A reagent needle 11 for storing liquid;

[0033] A support assembly for supporting the reagent needle 11;

[0034] A power mechanism for providing power for the movement of the reagent needle 11;

[0035] The axis of the power device in the power mechanism is aligned with the axis of the reagent needle 11; when the power device is started, the power device vibrates, driving the reagent needle 11 to vibrate. Through reasonable parameter selection, the tail of the reagent needle moves at a high frequency within a certain circumferential range, so as to cause the liquid in the reagent needle 11 to rotate and mix. During the liquid mixing process of the mixing structure of the present invention, only the reagent needle 11 contacts the reaction liquid, avoiding liquid loss caused by an additional stirring rod, which is helpful for subsequent mechanisms to accurately quantify the number of particles in the liquid.

[0036] It should be understood that the reasonable parameters include the length of the reagent needle, the output voltage of the winter device, etc.

[0037] It should be understood that the reagent needle 11 is a sampling needle, sample needle, pipetting needle, or reagent suction needle dedicated to biochemical equipment such as blood cells. In some embodiments, a liquid pipeline is provided in the reagent needle 11, and the outlet of the liquid pipeline is connected to a sampling pump to extract the liquid in the liquid pipeline. At this time, the device is suitable for automatically mixing and transferring various liquids. By integrating the common independent stirring and mixing structure into the sampling mechanism, the number of controlled components is greatly reduced, and the reliability of the mixing and sampling mechanism is increased.

[0038] In order to ensure that the reagent needle 11 still remains in a vertically downward state after vibration, in some embodiments, the support assembly further includes a movable mechanism, which drives the reagent needle 11 to vibrate when the power device is started, and the movable mechanism drives the reagent needle 11 to return to its original position when the power device is turned off.

[0039] In some embodiments, the movable mechanism includes a movable bottom plate 14 and a plurality of damping members 15, and the plurality of damping members 15 are disposed between the movable bottom plate 14 and the bottom of the mixing body 10. Specifically, the mixing body 10 includes a mixing base 16, and a plurality of damping members 15 are distributed between the mixing base 16 and the movable bottom plate 14; reagent needle receiving holes are provided on both the movable bottom plate 14 and the mixing base 16, and the reagent needle 11 extends from above the movable bottom plate 14 through the reagent needle receiving holes on the movable bottom plate 14 and the mixing base 16 in sequence to the lower side of the mixing base 16.

[0040] As Figure 2 shown, a second receiving hole 19 is provided on the movable bottom plate 14, and a first receiving hole 18 is provided on the mixing base 18. The first receiving hole 18 and the second receiving hole 19 provide sufficient movement space for the reagent needle 11. To ensure that the tail of the reagent needle 11 moves at a high frequency within a certain circumferential range.

[0041] It should be understood that the damping member can be a component formed of any material having a damping effect. For example, the damping member can be a rubber soft pad.

[0042] For the convenience of installation, the mixing base 16 can be set to an L shape. One side of the L shape is used for installing mixing structures such as reagent needles, and the other side of the L shape is used for fixedly installing the needle mixing structure on an automated detection device.

[0043] It should be understood that the mixing base 16 can be set to be stationary, or can be installed on other movable mechanisms with a self-locking structure.

[0044] To ensure the stability of the reagent needle when it returns to its original position, in some embodiments, the plurality of damping members 15 are evenly distributed under the movable bottom plate 14.

[0045] In some embodiments, the power device is a vibration motor 13, and an eccentric block 12 is installed on the main shaft of the vibration motor. After the vibration motor 13 is powered on, the main shaft of the vibration motor drives the eccentric block 12 to rotate, so as to drive the whole vibration motor 13 to vibrate.

[0046] To provide support for the power device, a motor mounting seat 17 is further included. The 17 motor mounting seat is fixedly connected to the support assembly, and the power device is fixedly connected to the motor mounting seat 17. Specifically, one end of the motor mounting seat 17 is fixedly installed with the movable bottom plate 14 (it should be understood that this fixed installation is a common fixed manner in the prior art), and the other end of the motor mounting seat 17 is fixedly connected to the power device (it should be understood that this fixed installation is a common fixed manner in the prior art).

[0047] In some embodiments, the motor mount 17 is in the shape of a housing, and at least part of the power device is accommodated within the motor mount 17. Specifically, one end of the motor mount 17 forms a power device mounting opening for mounting the power device; the mounting opening can be set to any shape, as long as it facilitates the installation of the power device. In some embodiments, when the power device is the vibration motor 13 and the eccentric block 12, the vibration motor 13 is supported by the edge of the power device mounting opening, and the eccentric block 12 is accommodated inside the motor mount 17 through the power device mounting opening.

[0048] In some embodiments, the motor mount 17 further includes a notch 20 through which the reagent needle 11 can be adjusted in position. In some embodiments, for ease of processing, the notch 20 can communicate with the power device mounting opening.

[0049] It should be understood that the input voltage of the vibration motor 13, the eccentricity of the eccentric block 12, the damping of the damping member 15, and the length of the reagent needle 11 can be adjusted; or the outer diameter of the movement trajectory of the end of the reagent needle 11 during tremor can be adjusted to adapt to the requirements of different sampling test tubes.

[0050] Embodiment Two

[0051] An automated detection device includes a device body; the device body includes a needle mixing structure as in Embodiment One.

[0052] A needle mixing structure includes a mixing body 10; the mixing body 10 includes:

[0053] A reagent needle 11 for storing liquid;

[0054] A support assembly for supporting the reagent needle 11;

[0055] A power mechanism for providing power for the movement of the reagent needle 11;

[0056] The axis of the power device in the power mechanism is aligned with the axis of the reagent needle 11; when the power device is started, the power mechanism vibrates, driving the reagent needle 11 to tremor, and further causing the tail of the reagent needle to move at a high frequency within a certain circumferential range, so as to promote the rotation and mixing of the liquid in the reagent needle 11. During the liquid mixing process of the mixing structure of the present invention, only the reagent needle 11 contacts the reaction liquid, avoiding liquid loss caused by an additional stirring rod, and helping the subsequent mechanism to accurately quantify the number of particles in the liquid.

[0057] The various embodiments in this specification are described in a progressive manner. For the same or similar parts among the various embodiments, reference can be made to each other, and the key point of each embodiment is to illustrate the differences from other embodiments. In particular, for the system embodiment, since it is basically similar to the method embodiment, the description is relatively simple, and for the relevant parts, reference can be made to the partial description of the method embodiment.

Claims

1. A needle mixing structure, comprising a mixing body; Characterized in that, The mixing body includes: A reagent needle for storing liquid; A support assembly for supporting the reagent needle; A power mechanism for providing power for the movement of the reagent needle; The axis of the power device in the power mechanism is aligned with the axis of the reagent needle; when the power device is started, the power device vibrates, driving the reagent needle to vibrate, and further causing the tail of the reagent needle to move at a high frequency within a certain circumferential range, so as to promote the rotation and mixing of the liquid in the reagent needle.

2. The needle mixing structure according to claim 1, Characterized in that, A liquid pipeline is provided in the reagent needle, and the outlet of the liquid pipeline is communicated with a sampling pump to take out the liquid in the liquid pipeline.

3. The needle mixing structure according to claim 1, Characterized in that, The support assembly further includes a movable mechanism, and the movable mechanism drives the reagent needle to vibrate when the power device is started, and the movable mechanism drives the reagent needle to return to its original position when the power device is turned off.

4. The needle mixing structure according to claim 3, Characterized in that, The movable mechanism includes a movable bottom plate and a plurality of damping members, and the plurality of damping members are arranged between the movable bottom plate and the bottom of the mixing body.

5. The needle mixing structure according to claim 4, Characterized in that, The plurality of damping members are evenly distributed under the movable bottom plate.

6. The needle mixing structure according to claim 1, Characterized in that, The power device is a vibration motor, and an eccentric block is installed on the main shaft of the vibration motor. After the vibration motor is powered on, the main shaft of the vibration motor drives the eccentric block to rotate, so as to drive the whole vibration motor to vibrate.

7. The needle mixing structure according to claim 1, Characterized in that, It further includes a motor mounting seat, the motor mounting seat is fixedly connected with the support assembly, and the power device is fixedly connected with the motor mounting seat.

8. The needle mixing structure according to claim 7, Characterized in that, The motor mounting seat is in the shape of a housing, and at least a part of the power device is accommodated in the motor mounting seat.

9. The needle mixing structure according to claim 8, Characterized in that, The motor mounting seat further includes a notch, and the reagent needle can be adjusted in position through the notch.

10. An automatic detection device, comprising a device body; Characterized in that, The device body includes the needle mixing structure according to any one of claims 1-9.

Citation Information

Patent Citations

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    CA2274887A1

  • Micro oscillator for instantly mixing medicaments in injection administration

    CN101589990A