Scanning and Mixing Device and Liquid-based Sample Preparation and Staining Machine

Abstract

This application relates to a code scanning and mixing device and a liquid-based sample preparation and staining machine. The code scanning and mixing device includes: a first driving mechanism and a code scanning and mixing assembly. The code scanning and mixing assembly includes a second driving mechanism, a clamping mechanism and a code scanner. The second driving mechanism is respectively connected to the first driving mechanism and the clamping mechanism, so that the first driving mechanism drives the clamping mechanism to clamp the sample container. The second driving mechanism is used to drive the clamping mechanism to rotate at a first rotation speed and a second rotation speed respectively, so that the code scanner can complete the code scanning operation on the sample container and the mixing operation on the sample inside it respectively. On the one hand, it has the advantages of compact structure and small volume, which is convenient for maintenance and has high working efficiency; on the other hand, it automatically switches different rotation speeds at the same position to realize the code scanning of the sample container and the mixing of the sample therein; on the other hand, it reduces the time for transportation between different workstations; on the other hand, it is beneficial to quickly reach the rotation speed required for mixing after the code scanning is completed, improving the efficiency of the mixing operation.

Description

Technical Field

[0001] The present application relates to liquid-based analysis, and in particular to a code scanning and mixing device and a liquid-based sample preparation and staining machine. Background Art

[0002] There are many ways to mix reagents, including internal stirring, vibration mixing and rocking mixing; vibration mixing and rocking mixing are commonly used for reagent bottles.

[0003] The operation of mixing reagents may usually involve standing, constant temperature, temperature increase and decrease, etc., but no mixing and code scanning are found to be processed together, that is, the traditional technology is to process mixing and code scanning separately. Among them, the mixing of samples in the sample bottle and the scanning of the sample bottle are often carried out in two stations, and a mechanism is required to realize the transportation between different stations, which not only takes up a large space, but also increases the cost and has low efficiency. Summary of the Invention

[0004] Based on this, it is necessary to provide a code scanning and mixing device and a liquid-based sample preparation and staining machine.

[0005] A code scanning and mixing device, comprising:

[0006] a first driving mechanism;

[0007] The code scanning and mixing component includes a second driving mechanism, a clamping mechanism and a code scanner. The second driving mechanism is connected to the first driving mechanism and the clamping mechanism respectively, so that the first driving mechanism drives the clamping mechanism to clamp the sample container. The second driving mechanism is used to drive the clamping mechanism to rotate at a first speed and a second speed respectively, so that the code scanner completes the code scanning operation on the sample container and completes the mixing operation of the sample in the sample container.

[0008] The above-mentioned code scanning and mixing device, on the one hand, has the advantages of compact structure and small size, convenient maintenance and high work efficiency; on the other hand, it can automatically switch different rotation speeds at the same position to realize code scanning of sample containers and mixing of samples therein; on the other hand, the second drive mechanism automatically matches the characteristics to realize the rotation of sample bottles at different speeds, reducing the transportation time between different workstations; on the other hand, since it is also rotating during the code scanning operation, it is beneficial to quickly reach the required mixing speed after the code scanning is completed, thereby improving the efficiency of the mixing operation.

[0009] In one embodiment, the code scanning and mixing device also includes a bracket, and the clamping mechanism includes a first clamping member and a second clamping member arranged opposite to each other, the first clamping member is connected to the bracket, and the second clamping member is connected to the second driving mechanism, so that the first driving mechanism drives the second clamping member away from or close to the first clamping member.

[0010] In one embodiment, the clamping mechanism further includes an elastic member, and the elastic member is respectively connected to the first clamping member and the bracket, so that the first clamping member and the second clamping member elastically clamp the sample container.

[0011] In one embodiment, the first driving mechanism includes a lead screw motor and a connecting member. The lead screw motor is connected to the bracket, and the connecting member is respectively connected to the output shaft of the lead screw motor and the second driving mechanism.

[0012] In one embodiment, the first driving mechanism further includes a guiding member, and the guiding member is respectively connected to the bracket and the connecting member.

[0013] In one embodiment, the code scanning and mixing device further includes a controller, and the controller is electrically connected to the first driving mechanism, the second driving mechanism and the code scanner respectively.

[0014] In one embodiment, the code scanning and mixing device further includes a control switch, and the control switch is electrically connected to the first driving mechanism, the second driving mechanism and the code scanner respectively.

[0015] In one embodiment, the code scanner is a bar code scanner or a two-dimensional code scanner.

[0016] In one embodiment, the code scanning and mixing device further includes a guide rail, the guide rail is fixed on the bracket, and the guide rail passes through the connecting member and is slidably arranged with the connecting member.

[0017] In one embodiment, the code scanning and mixing device further includes a sample tube rack, the sample tube rack is used for carrying the sample container, and the sample tube rack is provided with a scanning port.

[0018] A liquid-based sample preparation and staining machine includes a staining unit, a dehydration and fixation unit and any one of the code scanning and mixing devices. The code scanning and mixing device performs a code scanning operation on the sample container and a mixing operation on the sample in the sample container. The staining unit stains the sample that has completed the mixing operation, and the dehydration and fixation unit dehydrates and fixes the stained sample to make a sample substrate. Description of the Drawings

[0019] In order to more clearly illustrate the technical solutions in the embodiments of the present application or the prior art, the following will briefly introduce the drawings required for the description of the embodiments or the prior art. Obviously, the drawings in the following description are only some embodiments of the present application. For those of ordinary skill in the art, other drawings can be obtained based on these drawings without creative efforts.

[0020] Figure 1 Schematic diagram of an embodiment of the code scanning and mixing structure of the present application.

[0021] Figure 2 For Figure 1 Another direction schematic diagram of the illustrated embodiment.

[0022] Figure 3 Schematic diagram of another embodiment of the code scanning and mixing structure of the present application.

[0023] Figure 4 For Figure 3 Another direction schematic diagram of the illustrated embodiment.

[0024] Figure 5 Schematic diagram of another embodiment of the code scanning and mixing structure of the present application.

[0025] Figure 6 For Figure 5 Another direction schematic diagram of the illustrated embodiment.

[0026] Figure 7 Schematic diagram of another embodiment of the code scanning and mixing structure of the present application.

[0027] Figure 8 Schematic diagram of another embodiment of the code scanning and mixing structure of the present application.

[0028] Figure 9 For Figure 8 Another direction schematic diagram of the illustrated embodiment.

[0029] Figure 10 Schematic diagram of another embodiment of the code scanning and mixing structure of the present application.

[0030] Figure 11 For Figure 10 Application schematic diagram of the illustrated embodiment.

[0031] Figure 12 Schematic diagram of another embodiment of the code scanning and mixing structure of the present application.

[0032] Figure 13 For Figure 12 Magnified schematic diagram of part A of the illustrated embodiment.

[0033] Figure 14 For Figure 12 Another direction schematic diagram of the illustrated embodiment.

[0034] Figure 15 For Figure 12 Another direction schematic diagram of the illustrated embodiment.

[0035] Figure 16 For Figure 12 Another direction schematic diagram of the illustrated embodiment.

[0036] Figure 17 Another schematic diagram of the illustrated embodiment in another direction. Figure 12 Another schematic diagram of the illustrated embodiment in another direction.

[0037] Figure 18 Another enlarged schematic diagram of part B of the illustrated embodiment. Figure 12 Another enlarged schematic diagram of part B of the illustrated embodiment.

[0038] Figure 19 Another enlarged schematic diagram of part B of the illustrated embodiment. Figure 18 Another enlarged schematic diagram of part B of the illustrated embodiment.

[0039] Reference numerals:

[0040] Sample container 100, sample tube rack 200, first clamping member 300, elastic member 400, barcode scanner 500, second clamping member 600, second driving mechanism 700, guide rail 800, bracket 900, lead screw motor 910, cover body 110, tube body 120, scanning port 210, guide post 410, fixing block 420, connecting rod 430, elastic block 440, abutting portion 610, socket portion 620, processing area 666, rotating rod 710, guiding member 810, first guide rail 801, second guide rail 802, support frame 820, connecting member 830, first connecting member 831, second connecting member 832, third connecting member 833, output shaft 920, first fastener 930, second fastener 940, fixing frame 950, first driving mechanism 901, clamping mechanism 999. Detailed embodiments

[0041] To make the above objects, features, and advantages of the present application more apparent and understandable, the following detailed description of the specific embodiments of the present application will be given with reference to the accompanying drawings. Many specific details are set forth in the following description to facilitate a thorough understanding of the present application. However, the present application can be implemented in many other ways different from those described herein, and those skilled in the art can make similar improvements without departing from the spirit of the present application. Therefore, the present application is not limited by the specific embodiments disclosed below.

[0042] In addition, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the quantity of the indicated technical features. Thus, features defined with "first" and "second" may explicitly or implicitly include at least one of such features. In the description of the present application, "a plurality" means at least two, such as two, three, etc., unless otherwise specifically defined.

[0043] In this application, unless otherwise clearly defined and limited, the first feature being "on" or "under" the second feature may be that the first feature is in direct contact with the second feature, or the first feature is in indirect contact with the second feature through an intermediate medium. Moreover, the first feature being "above", "over" and "on top of" the second feature may be that the first feature is directly above or obliquely above the second feature, or merely indicates that the horizontal height of the first feature is higher than that of the second feature. The first feature being "under", "beneath" and "underneath" the second feature may be that the first feature is directly below or obliquely below the second feature, or merely indicates that the horizontal height of the first feature is less than that of the second feature.

[0044] It should be noted that when an element is referred to as "fixed to" or "disposed on" another element, it can be directly on the other element or there may also be an intermediate element. When an element is considered to be "connected to" another element, it can be directly connected to the other element or there may be an intermediate element at the same time. The terms "vertical", "horizontal", "upper", "lower", "left", "right" and similar expressions used herein are only for illustrative purposes and do not represent the only implementation.

[0045] In order to solve the problem of code scanning in cooperation with mixing at the same time, in an embodiment of this application, a code scanning and mixing device includes: a first driving mechanism and a code scanning and mixing assembly. The code scanning and mixing assembly includes a second driving mechanism, a clamping mechanism and a code scanner. The second driving mechanism is respectively connected to the first driving mechanism and the clamping mechanism, so that the first driving mechanism drives the clamping mechanism to clamp the sample container, and the second driving mechanism is used to drive the clamping mechanism to rotate at a first rotation speed and a second rotation speed respectively, so that the code scanner can complete the code scanning operation on the sample container and the sample in the sample container can complete the mixing operation. The above-mentioned code scanning and mixing device has the advantages of compact structure and small volume on the one hand, which is convenient for maintenance and has high working efficiency; on the other hand, it can automatically switch different rotation speeds at the same position to realize the code scanning of the sample container and the mixing of the sample therein; on the other hand, the second driving mechanism is used to automatically match the features to realize the rotation of the sample bottle at different speeds, reducing the time for transportation between different workstations; on the other hand, since it is also rotating during the code scanning operation, it is beneficial to quickly reach the rotation speed required for mixing after the code scanning is completed, improving the efficiency of the mixing operation.

[0046] In one embodiment, a code scanning and mixing device includes some or all of the structures of the following embodiments; that is, the code scanning and mixing device includes some or all of the following technical features. In one embodiment, the first driving mechanism is used to drive the clamping mechanism, drive the second driving mechanism to drive the clamping mechanism, or simultaneously drive the clamping mechanism and the second driving mechanism. Further, the first driving mechanism has a linear motor, and the linear motor drives the clamping mechanism to linearly move to clamp the current sample container. Such a design provides a simple and efficient way to drive the clamping mechanism so that the clamping mechanism clamps the sample container, and a mixing effect is achieved under the action of the second driving mechanism.

[0047] To complete code scanning and mixing of the sample container at the same position, in one embodiment, the code scanning and mixing assembly includes a second driving mechanism, a clamping mechanism, and a code scanner. The second driving mechanism is respectively connected to the first driving mechanism and the clamping mechanism, so that the first driving mechanism drives the clamping mechanism to clamp the sample container. The second driving mechanism is used to drive the clamping mechanism to rotate at a first speed and a second speed respectively, so that the code scanner completes the code scanning operation on the sample container and the sample in the sample container completes the mixing operation. When the second driving mechanism drives the clamping mechanism to rotate at the first speed, the code scanner completes the code scanning operation on the sample container, that is, the code scanner completes the code scanning operation on the sample container when the clamping mechanism rotates at the first speed. When the second driving mechanism drives the clamping mechanism to rotate at the second speed, the sample in the sample container completes the mixing operation, that is, the sample in the sample container completes the mixing operation when the clamping mechanism rotates at the second speed. Further, in one embodiment, the code scanning and mixing assembly is used to automatically switch different rotation speeds at the same position to achieve code scanning of the sample container and mixing of the sample therein. For example, the first speed is 10 rpm to 100 rpm, the second speed is 50 rpm to 500 rpm, etc. This application does not impose additional restrictions on the first speed and the second speed, as long as code scanning or mixing can be respectively achieved within the corresponding speed ranges. It can be understood that low-speed code scanning and high-speed mixing are already part of the prior art, but creatively combining the two is beneficial to reducing the overall volume, having the advantages of a compact structure and a small volume, being convenient for maintenance, and having high working efficiency.

[0048] In one embodiment, to implement the barcode scanning of the sample container, the barcode scanner is a bar code scanner or a two-dimensional code scanner. With such a design, the sample container at the barcode scanning position, i.e., the processing area, can be scanned for barcodes or two-dimensional codes to read information, thereby marking the samples in the sample container to facilitate subsequent operations such as staining and avoid confusion. Moreover, since the barcode scanning is performed during rotation, on the one hand, it has the advantage of high working efficiency, and on the other hand, it is beneficial to quickly increase the speed for mixing after barcode scanning, for example, using the existing rotation speed as the initial speed. In one embodiment, the sample container is tubular, i.e., it is a sample tube. In one embodiment, the sample container has a detachable lid and a tube body, where the tube body is used to hold the sample and the lid is used to seal the tube body. To facilitate the second drive mechanism to drive the clamping mechanism to rotate at the first speed and the second speed respectively, in one embodiment, the barcode scanning and mixing device further includes a controller, which is electrically connected to the barcode scanner and used to control the barcode scanning operation of the barcode scanner. In one embodiment, the barcode scanning and mixing device further includes a controller, which is respectively electrically connected to the first drive mechanism, the second drive mechanism and the barcode scanner. In one embodiment, the barcode scanning and mixing device further includes a controller, which is respectively electrically connected to the first drive mechanism, the second drive mechanism and the barcode scanner to implement power-on and power-off control. The first drive mechanism is used to drive the clamping mechanism, such as its second clamping member, to rise or fall by a preset height when powered on. The second drive mechanism is used to drive the clamping mechanism, such as its second clamping member, to rotate at the first speed and the second speed respectively when powered on, for example, in different power-on states. The barcode scanner is used to complete the barcode scanning operation of the sample container when powered on. In one embodiment, the barcode scanning and mixing device further includes a control switch, which is respectively electrically connected to the first drive mechanism, the second drive mechanism and the barcode scanner. Such a design is beneficial in simplifying the control method on the one hand, reducing the product volume on the other hand, further enhancing the advantages of a compact product structure and small volume, and saving control costs on the third hand. One controller can effectively control the first drive mechanism, the second drive mechanism and the barcode scanner.

[0049] In one embodiment, as Figure 1As shown, a scanning and mixing device includes: a first driving mechanism 901 and a scanning and mixing assembly; wherein, the scanning and mixing assembly includes a second driving mechanism 700, a clamping mechanism 999 and a scanner 500. The second driving mechanism 700 is respectively connected to the first driving mechanism 901 and the clamping mechanism 999. In this embodiment, the scanning and mixing device further includes a bracket 900. The clamping mechanism 999 includes a first clamping member 300 and a second clamping member 600 arranged oppositely. The first clamping member 300 is connected to the bracket 900, and the second clamping member 600 is connected to the second driving mechanism 700, so that the first driving mechanism 901 drives the second clamping member 600 to move away from or close to the first clamping member 300. The first driving mechanism 901 includes a screw motor 910 and a connecting member 830. The screw motor 910 is connected to the bracket 900, and the connecting member 830 is respectively connected to the output shaft 920 of the screw motor 910 and the second driving mechanism 700. With such a design, different rotation speeds can be automatically switched at the same position to realize the scanning of the sample container and the mixing of the sample therein. In one embodiment, the clamping mechanism is a pressing clamping mechanism or an enclosing clamping mechanism. In one embodiment, both the first clamping member and the second clamping member are pressing clamping members. In one embodiment, the second driving mechanism is a mixer, such as a rotary mixing motor. The screw motor of the first driving mechanism is used to move the second clamping member up and down or move the rotary mixing motor up and down to drive the second clamping member to move up and down.

[0050] Please refer to Figure 11 simultaneously. The first driving mechanism 901 drives the second clamping member 600 in the clamping mechanism 999 to rise, that is, the second clamping member 600 approaches the first clamping member 300. When it rises to a certain extent, the first clamping member 300 and the second clamping member 600 cooperate to jointly clamp the sample container 100. The second driving mechanism 700 is used to drive the clamping mechanism 999 to rotate at a first speed and a second speed respectively, so that the scanner 500 can complete the scanning operation on the sample container 100 and the sample in the sample container 100 can complete the mixing operation; further, the screw motor 910 is connected to the bracket 900 through a fixing frame 950. Further, please refer to Figure 2, the first clamping member 300 and the second clamping member 600 are arranged oppositely to form a processing area 666. The processing area 666 faces the scanner 500 and is used to accommodate the sample container 100. In use, the lead screw motor 910 drives the output shaft 920 to drive the connecting member 830 to approach the first clamping member 300, so that the second clamping member 600 approaches the first clamping member 300. The first clamping member 300 and the second clamping member 600 jointly clamp the sample container 100 in the processing area 666. The second driving mechanism 700 drives the second clamping member 600 to rotate at a first speed, and the scanner 500 scans the sample container 100 in the processing area 666 to complete the scanning operation. Then, the second driving mechanism 700 drives the second clamping member 600 to rotate at a second speed to complete the mixing operation of the sample in the sample container 100. The second driving mechanism 700 is fixed under the connecting member 830 and the second clamping member 600 is located on the connecting member 830; the second driving mechanism 700 is fixed on the connecting member 830; or, the second driving mechanism 700 is fixed on one side of the connecting member 830. Such a design is conducive to automatically matching the second driving mechanism with the scanning feature or the mixing feature, that is, the operation requirement, realizing the rotation of the sample bottle at different speeds, and reducing the time for transportation between different workstations; and since it is also rotating during the scanning operation, it is conducive to quickly reaching the required rotation speed for mixing after the scanning is completed, improving the efficiency of the mixing operation.

[0051] In order to enable the first clamping member to rotate along with it, further, in one embodiment, as Figure 3 , Figure 4 and Figure 7 shown, the scanning and mixing device further includes a guide post 410 and a fixing block 420. The fixing block 420 is fixed on the bracket 900. The guide post 410 is rotatably arranged on the fixing block 420. The first clamping member 300 is fixed on the guide post 410. In one embodiment, the scanning and mixing device further includes a connecting rod 430. The connecting rod 430 is arranged on the bracket 900. The first clamping member 300 is fixed on the connecting rod 430. In one embodiment, the connecting rod 430 is an elastic deformation structure. Please refer to Figure 10 , the clamping mechanism further includes an elastic member 400. The elastic member 400 is respectively connected to the first clamping member 300 and the bracket 900 so that the first clamping member 300 and the second clamping member 600 elastically clamp the sample container 100. In this embodiment, the elastic member 400 is a spring. Please refer to Figure 11 and Figure 12, the sample container 100 is located between the first clamping member 300 and the second clamping member 600. When the second clamping member 600 approaches the first clamping member 300 to a certain distance, the first clamping member 300 and the second clamping member 600 will jointly clamp and fix the sample container 100. The second clamping member 600 rotates at a first rotation speed and a second rotation speed respectively under the drive of the second drive mechanism 700, driving the first clamping member 300 and the sample container 100 to rotate together at the first rotation speed and the second rotation speed respectively, so as to realize the barcode scanning operation of the sample container at the same position and the mixing operation of the sample in its content. In one embodiment, as Figure 3 and Figure 4 shown, the barcode scanning and mixing device further includes an elastic block 440. The elastic block 440 is fixed under the first clamping member 300 and is located between the first clamping member 300 and the second clamping member 600. The elastic member 400 and the elastic block 440 have similar functions and are used to deform when contacting the sample container 100 to avoid exerting excessive pressure on the sample container 100; further, the elastic member 400 or the elastic block 440 is rotatably arranged on the first clamping member 300. Such a design can also cooperate with the first clamping member 300 to rotate together.

[0052] In order to more firmly fix the connecting piece and avoid out-of-control accidents during rotational mixing, further, in one embodiment, as Figure 5 and Figure 6 shown, the barcode scanning and mixing device further includes a first fastener 930 and a second fastener 940. The first fastener 930 and the second fastener 940 are respectively fixed on the output shaft 920, and the first fastener 930 and the second fastener 940 jointly clamp the connecting piece 830.

[0053] In order to facilitate the separate production of each structural member and jointly assemble the lead screw motor and the bracket, further, in one embodiment, as Figure 8 and Figure 9 shown, the barcode scanning and mixing device further includes a fixing frame 950. The fixing frame 950 is fixedly arranged on the bracket 900, and the lead screw motor 910 is connected to the bracket 900 through the fixing frame 950. Such a design is beneficial to quickly and firmly install the lead screw motor and is easy to overhaul and maintain.

[0054] In order to facilitate continuous operation and realize automatic barcode scanning, further, in one embodiment, as Figure 12 and Figure 14As shown, the code scanning and mixing device further includes a sample tube rack 200 for carrying the sample container 100 and placing the sample container 100 in the processing area 666 for code scanning and mixing processing. The sample tube rack 200 is provided with a scanning port 210, and the scanning port 210 faces the scanner 500. In this embodiment, the sample container 100 has a connected lid 110 and a tube body 120. Please refer to Figure 12 , Figure 15 and Figure 16 . During the code scanning and mixing processing, the sample container 100 is lifted from the sample tube rack 200, and the bottom of the tube body 120 of other sample containers is as shown in the figure. Taking the sample container 100 as a reference, it can be seen that the overall volume of the code scanning and mixing device described in the present application is very small and compact relative to the sample container 100; and due to the ingenious structural design, it is easy to disassemble and assemble, thus having the advantage of convenient maintenance.

[0055] Further, in one embodiment, the code scanning and mixing device further includes a conveying mechanism connected to the sample tube rack. The conveying mechanism is used to drive the sample tube rack to move so that a sample container in the sample tube rack is located in the processing area for the code scanner to perform a code scanning operation on the sample container, that is, to complete the code scanning operation, and for the second driving mechanism to perform a mixing operation on the sample in the sample container, that is, to complete the mixing operation. Further, in one embodiment, the controller is also linked with the conveying mechanism, or the controller is used to control the conveying mechanism to drive the sample tube rack to move. Such a design is conducive to realizing automatic sample injection on the one hand, to coordinating with realizing automatic sample injection, code scanning and mixing on the other hand, and to overall realizing a code scanning and mixing device with a small structure and high processing efficiency.

[0056] Please refer to Figure 13 . In one embodiment, the code scanning and mixing device further includes a guide rail 800 fixed to the bracket 900. The guide rail 800 passes through the connecting member 830 and is slidably arranged with the connecting member 830. In one embodiment, the number of the guide rails 800 is at least two and the guide rails 800 are arranged in parallel. As Figure 13In the illustrated embodiment, the number of guide rails is two, that is, the guide rail 800 includes a first guide rail 801 and a second guide rail 802. Among them, the first guide rail 801 and the second guide rail 802 are arranged in parallel to provide a balanced guiding force, ensuring that the connecting member 830 can provide stable support relative to the second clamping member 600 and the second driving mechanism 700. In one embodiment, the first driving mechanism further includes a guiding member 810, and the guiding member 810 is respectively connected to the bracket 900 and the connecting member 830. Such a design is conducive to cooperating to firmly fix the connecting member and the second driving mechanism and the second clamping member connected thereto.

[0057] Please refer to Figure 13 , in one embodiment, the second driving mechanism 700 is provided with a rotating rod 710, and the second clamping member 600 is sleeved on the rotating rod 710. Please refer to Figure 17 , in one embodiment, the second driving mechanism 700 is provided with a rotating rod 710, the second clamping member 600 is provided with a connected abutting portion 610 and a socket portion 620, the socket portion 620 is sleeved on the rotating rod 710, and the abutting portion 610 is used for abutting against the sample container 100. In one embodiment, the code scanning and mixing device further includes a guiding member 810 and a support frame 820. The guiding member 810 and the support frame 820 are respectively fixed on the bracket 900. One end of the guide rail 800 is fixed to the guiding member 810, and the other end is fixed to the support frame 820, so that the guide rail 800 is fixed on the bracket 900. Such a design, on the one hand, is conducive to firmly connecting the guide rail to provide effective guidance for the connecting member, and on the other hand, is conducive to cooperating to achieve a compact structure and reduce the volume of the product.

[0058] In one embodiment, as Figure 18 and Figure 19As shown, the connecting member 830 includes a first connecting member 831, a second connecting member 832 and a third connecting member 833 connected to each other. The first connecting member 831 passes through the output shaft 920 of the screw motor 910. The first fastener 930 and the second fastener 940 are respectively located on both sides of the first connecting member 831 to cooperate in fastening the first connecting member 831 to the output shaft 920; the guide rail 800 passes through the third connecting member 833 and is slidably arranged with the third connecting member 833, and the second driving mechanism 700 is fixed to the third connecting member 833. In one embodiment, the code scanning and mixing device also includes a guide rail 800, which is fixed on the bracket 900; the connecting member 830 is integrally provided with a first connecting member 831, a second connecting member 832 and a third connecting member 833; wherein, the first connecting member 831 is fixed on the output shaft 920 of the screw motor 910, the second connecting member 832 passes through the guide rail 800 and is slidably arranged with the guide rail 800, and the second driving mechanism 700 is fixed to the third connecting member 833.

[0059] In one embodiment, the sample container 100 is placed in the sample tube rack 200 and is sent to the mixing scanning position, i.e., the processing area 666, as the sample container 100. The linear motor of the first drive mechanism 901, such as the screw motor 910, drives the second drive mechanism 700, such as the rotary mixing motor, to move upward along the guide rail 800, such as the linear guide rail, and lifts the sample container 100 through the second clamping member 600 until the sample container 100 is supported by the first clamping member 300. The sample container 100 is fixed in place under the pressure of the elastic member 400, such as the spring. Between the first clamping member 300 and the second clamping member 600, it is understood that the clamping method of the clamping mechanism 999, such as the pressing method, includes but is not limited to pressing the sample container 100 by means of rubber deformation or a plunger, or pressing the sample container 100 by means of a spring, a spring, or the like. Then, driven by the second driving mechanism 700, such as a rotary mixing motor, the sample container 100 can be rotated at a low speed to obtain the barcode information on the sample container 100 through the scanning port 210 on the sample tube rack 200 using a barcode scanner 500, such as a barcode scanner, or can be rotated at a high speed to perform a mixing operation. After all operations are completed, the screw motor 910 drives the second driving mechanism 700 downward, and the mixed sample container 100 returns to the sample tube rack 200. The next sample container 100 is then transported by the conveying mechanism, and the sample container 100 that has previously completed scanning and mixing leaves the processing area 666. This design enables two power sources to mix sample tubes and scan barcodes at the same workstation. The entire structure is compact, simple, and easy to maintain, with high work efficiency. At the same time, the mechanism automatically matches features to achieve rotation of sample containers at different speeds. This not only has a simple structure and low cost, but also reduces the time for transportation between different workstations.

[0060] In one embodiment, a liquid-based sample preparation and staining machine includes a staining unit, a dehydration and fixation unit, and the barcode scanning and mixing device described in any of the embodiments. The barcode scanning and mixing device performs barcode scanning on the sample container and mixing on the sample in the sample container. The staining unit stains the sample that has completed the mixing operation, and the dehydration and fixation unit dehydrates and fixes the stained sample to make a sample substrate. Such a design has the advantages of compact structure and small size on the one hand, which is convenient for maintenance and has high working efficiency; on the other hand, it can automatically switch different rotation speeds at the same position to achieve barcode scanning of the sample container and mixing of the sample therein; on the other hand, the second driving mechanism is used to automatically match features to achieve rotation of the sample bottle at different speeds, reducing the time for transportation between different workstations; on the other hand, since it is also rotating during barcode scanning, it is beneficial to quickly reach the rotation speed required for mixing after barcode scanning is completed, improving the efficiency of the mixing operation; on the other hand, it is beneficial to cooperate with related operations such as staining and dehydration and fixation to achieve automated processing.

[0061] It should be noted that other embodiments of the present application further include a barcode scanning and mixing device and a liquid-based sample preparation and staining machine that can be implemented formed by combining the technical features in the above embodiments.

[0062] The technical features of the above-described embodiments can be combined arbitrarily. For the sake of brevity of description, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, it should be considered to be within the scope described in this specification. And the above-described embodiments only represent several implementation manners of the present application, and their descriptions are relatively specific and detailed, but they should not be construed as a limitation on the scope of the patent application. It should be pointed out that for those of ordinary skill in the art, without departing from the concept of the present application, several modifications and improvements can be made, and these all belong to the protection scope of the present application. Therefore, the protection scope of the patent of the present application should be subject to the appended claims.

Claims

1. A liquid-based sample preparation and staining machine, characterized in that, It includes a staining unit, a dehydration and fixation unit, and a barcode scanning and mixing device. The barcode scanning and mixing device performs barcode scanning on the sample container and mixing on the sample in the sample container. The staining unit stains the sample that has completed the mixing operation. The dehydration and fixation unit dehydrates and fixes the stained sample to make a sample substrate. The barcode scanning and mixing device includes: A first driving mechanism; A barcode scanning and mixing assembly, including a second driving mechanism, a clamping mechanism, and a barcode scanner. The second driving mechanism is respectively connected to the first driving mechanism and the clamping mechanism, so that the first driving mechanism drives the clamping mechanism to clamp the sample container, and the second driving mechanism is used to drive the clamping mechanism to rotate at a first rotation speed and a second rotation speed respectively, so that the barcode scanner completes barcode scanning on the sample container and mixing on the sample in the sample container respectively; Wherein, the barcode scanning and mixing assembly is used to automatically switch different rotation speeds at the same position to realize barcode scanning of the sample container and mixing of the sample in the sample container. The second driving mechanism abuts against the bottom of the sample container through an abutting part to drive barcode scanning of the sample container and mixing of the sample in the sample container; The barcode scanning and mixing device further includes a bracket, a guide post, and a fixing block. The clamping mechanism includes a first clamping member and a second clamping member arranged oppositely. The first clamping member is connected to the bracket, and the second clamping member is connected to the second driving mechanism, so that the first driving mechanism drives the second clamping member to move away from or close to the first clamping member; The fixing block is fixed on the bracket, the guide post is rotatably arranged on the fixing block, and the first clamping member is fixed on the guide post; the barcode scanning and mixing device further includes a connecting rod, the connecting rod is arranged on the bracket, the first clamping member is fixed on the connecting rod, and the connecting rod is an elastic deformation structure.

2. The liquid-based sample preparation and staining machine according to claim 1, wherein, The clamping mechanism further includes an elastic member, and the elastic member is respectively connected to the first clamping member and the bracket, so that the first clamping member and the second clamping member elastically clamp the sample container.

3. The liquid-based sample preparation and staining machine according to claim 1, wherein The first driving mechanism includes a lead screw motor and a connecting member. The lead screw motor is connected to the bracket, and the connecting member is respectively connected to the output shaft of the lead screw motor and the second driving mechanism. Wherein, the first clamping member and the second clamping member are oppositely arranged to form a processing area, the processing area faces the barcode scanner and is used for accommodating the sample container. In use, the lead screw motor drives the output shaft to drive the connecting member close to the first clamping member, so that the second clamping member approaches the first clamping member. The first clamping member and the second clamping member jointly clamp the sample container in the processing area. The second driving mechanism drives the second clamping member to rotate at a first speed, and the barcode scanner scans the sample container in the processing area to complete the scanning operation. Then, the second driving mechanism drives the second clamping member to rotate at a second speed to complete the mixing operation of the sample in the sample container. The second driving mechanism is fixed under the connecting member and the second clamping member is located on the connecting member; alternatively, the second driving mechanism is fixed on the connecting member; alternatively, the second driving mechanism is fixed on one side of the connecting member.

4. The liquid-based sample preparation and staining machine according to claim 3, characterized in that, The first driving mechanism further includes a guiding member, and the guiding member is respectively connected to the bracket and the connecting member.

5. The liquid-based sample preparation and staining machine according to claim 3, wherein It further includes a guide rail, the guide rail is fixed on the bracket, and the guide rail passes through the connecting member and is slidably arranged with the connecting member.

6. The liquid-based sample preparation and staining machine according to claim 3, characterized in that, It further includes a controller, and the controller is electrically connected to the first driving mechanism, the second driving mechanism and the barcode scanner respectively.

7. The liquid-based sample preparation and staining machine according to claim 1, wherein The barcode scanner is a bar code scanner or a two-dimensional code scanner.

8. The liquid-based sample preparation and staining machine according to claim 6, wherein, It further includes a sample tube rack, the sample tube rack is used for carrying the sample container, and the sample tube rack is provided with a scanning opening. The barcode scanning and mixing device further includes a conveying mechanism, the conveying mechanism is connected to the sample tube rack, and the conveying mechanism is used for driving the sample tube rack to move so that a sample container in the sample tube rack is located in the processing area for the barcode scanner to scan the sample container and for the second driving mechanism to mix the sample in the sample container.

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