Real-time sampling device

Abstract

Various disclosed embodiments include illustrative devices and systems for performing multilumen catheter functions, and methods of manufacturing such devices. The illustrative device includes a multilumen sheath; a cap having a proximal end attachable to the distal end of the multilumen sheath; and a liner. The cap includes a ramp section having a ramp and an outlet port, and an imaging section disposed distally from the ramp section. The ramp allows the medical device to travel from within the liner to the outlet port. The distal ramp section extends distally from a flexible proximal section and is received by the ramp of the ramp section. The distal ramp section has a curved portion. The cap includes an insertion port for receiving a tongue of the distal ramp section. The curved portion includes a bend gap feature.

Description

[0001] Priority requirements

[0002] This application claims the benefit of U.S. Provisional Patent Application No. 63 / 150,708, filed February 18, 2021, the contents of which are incorporated herein by reference. Background Technology

[0003] The statements in this section provide only background information in relation to this disclosure and may not constitute prior art.

[0004] Inserting and manipulating thin, elongated instruments within living bodies or other objects allows for increasingly sophisticated analysis, diagnosis, and treatment of these bodies or objects using minimally invasive techniques. For example, endoscopic imaging and catheter-based therapies enable the evaluation and treatment of many internal lesions without invasive surgery.

[0005] Correspondingly, slender instruments can also be used to collect samples from inside the body in a relatively non-invasive manner. For example, when a biopsy is needed from the lungs to determine whether a detected lesion is cancerous, an insertable device (such as a bronchoscope) can be used to guide one or more slender instruments to a location near the lesion to obtain a sample, rather than cutting into the patient's chest. However, simply delivering a slender instrument to a location near the lesion may only present a portion of what is needed to sample the lesion itself. Summary of the Invention

[0006] Various publicly available implementations include illustrative devices and systems for obtaining tissue samples.

[0007] In an illustrative embodiment, the device includes: a multi-chamber sheath; a cap having a proximal end attachable to the distal end of the multi-chamber sheath; and a liner. The cap includes a ramp section having a ramp and an outlet port, and an imaging section disposed distally from the ramp section. The ramp allows the medical device to travel from within the liner to the outlet port. The liner includes a flexible proximal section and a distal ramp section having a C-shaped cross-section. The distal ramp section extends distally from the flexible proximal section and is received by the ramp of the ramp section of the cap. The distal ramp section includes a longitudinal axis having a radius of curvature along at least a portion of the distal ramp section.

[0008] In another illustrative embodiment, the cap includes a spigot disposed at the distal end of the ramp. The liner also includes a tab disposed distally from the distal ramp section. During assembly, the tab is received within the spigot. The liner also includes a neck section disposed between the distal ramp section and the tab.

[0009] In another illustrative embodiment, the system includes a medical device and a multi-cavity device. The multi-cavity device includes: a multi-cavity sheath; a cap having a proximal end attachable to the distal end of the multi-cavity sheath; and a liner. The cap includes a ramp section having a ramp and an outlet port, and an imaging section disposed distally from the ramp section. The ramp allows the medical device to travel from within the liner to the outlet port. The liner includes a flexible proximal section and a distal ramp section having a C-shaped cross-section. The distal ramp section extends distally from the flexible proximal section and is received by the ramp of the ramp section of the cap. The distal ramp section includes a longitudinal axis having a radius of curvature along at least a portion of the distal ramp section.

[0010] In another illustrative embodiment, a method for manufacturing the above-described device is provided.

[0011] The foregoing summary is illustrative only and is not intended to be limiting in any way. Other aspects, embodiments, and features will become apparent from the accompanying drawings and the following detailed description, in addition to the illustrative aspects, embodiments, and features described above. Attached Figure Description

[0012] Illustrative embodiments are illustrated in the accompanying drawings. The embodiments and drawings disclosed herein should be considered illustrative, not restrictive.

[0013] Figure 1 This is a side view of the illustrative sampling system.

[0014] Figure 2 Is Figure 1 An X-ray view of the distal end of a portion of an illustrative multilumen catheter used in the system.

[0015] Figure 3 yes Figure 1 A plan view of the system components.

[0016] Figure 4 yes Figure 3 An isometric view of the components.

[0017] Figure 5 Is Figure 1 A partial isometric X-ray view of a portion of the distal tip used in the system.

[0018] Figure 6 Is Figure 1 A partial X-ray side view of a distal portion of an illustrative multilumen catheter used in the system.

[0019] Figure 7 It is an isometric partial X-ray view of a portion of the distal end of an illustrative multilumen catheter.

[0020] Figure 8 This is a partial isometric X-ray view of a portion of the distal end of an illustrative multilumen catheter.

[0021] Figure 9 This is a partial isometric X-ray view of a portion of the distal end of an illustrative multilumen catheter.

[0022] Figure 10 This is a partial isometric X-ray view of a portion of the distal end of an illustrative multilumen catheter.

[0023] Figure 11 It is a flowchart illustrating an illustrative method for creating an illustrative multi-lumen catheter.

[0024] The same reference symbols in different figures usually represent the same components. Detailed Implementation

[0025] The following description explains, by way of illustration and not limitation, various embodiments of devices and systems for sampling tissues using a multi-cavity device that can be inserted into the body.

[0026] It is understood that various embodiments of the system described herein can aid in the deployment and control of elongated instruments. In various embodiments, the system includes a multi-chamber device that may include a sheath containing an imaging probe and a sampling needle. The sheath can be inserted into the body to reach the target tissue to be sampled. The imaging probe can be used to locate the tissue or a portion of the tissue to be sampled. The sampling needle can be used to obtain a sample of the tissue.

[0027] In various embodiments, the system can be coupled to an insertion device (such as an endoscope or bronchoscope) that includes an insertion catheter that can be inserted into the body through an orifice or other opening. The insertion device enables the insertion catheter to be inserted into the body and guided to a desired location within the body. The insertion catheter can be configured to receive a multi-lumen device that can extend through the insertion catheter. The multi-lumen device is inserted into the body via the insertion device to obtain tissue samples at a desired location within the body. An illustrative multi-lumen device is described below.

[0028] In various implementation schemes, such as Figure 1 As shown, the illustrative system 12 includes an insertion device 18. Figure 1 Only a portion of the insertion device 18 is shown in the image, such as an endoscope or bronchoscope. As previously described, the insertion device 18 includes an insertion catheter that can pass through an orifice or other opening ( Figure 1(Not shown in the image) is inserted into the body. The insertion device 18 receives a multi-lumen catheter device 14, which receives a medical device 16 that can be extended through the lumen of the multi-lumen catheter device 14 to a desired location. As previously described, in various embodiments, the medical device 16 may include an imaging probe and / or a sampling needle coupled to a handle and contained within a sheath. Figure 1 (These are not shown separately). The medical device 16 can be inserted via the multi-lumen catheter device 14 and the insertion device 18 to obtain tissue samples at a desired location within the body.

[0029] It is understood that the insertion device 18 can be any of a variety of different types of endoscopes used in medical procedures. This range may include multi-purpose or single-purpose endoscopes such as bronchoscopes, laryngoscopes, laryngoscopes, etc. The multi-lumen catheter device 14 can be any device comprising two or more lumens located within an insertion tube attached to a handle device. The lumens of the multi-lumen catheter device 14 may be adapted to receive imaging devices and medical devices 16. The received imaging devices may include cameras or ultrasound devices, such as radial ultrasound probes or similar devices. In various embodiments, the multi-catheter device 14 may include a base segment rotatably coupled to the insertion device 18 and a port slidably received by the base segment. An illustrative multi-catheter system is shown and described in U.S. Provisional Patent Application No. 63 / 123,731, filed December 10, 2020, the contents of which are incorporated herein by reference.

[0030] In various embodiments, the insertion cannula of the multilumen catheter device 14 is received within the working channel port of the insertion device 18. The multilumen catheter device 14 may be attached to the working channel port. The medical device 16 may include a flexible sheath attached to a first portion of the handle, and an operating tool received within the flexible sheath and attached to the actuator portion of the handle. The operating tool may include a tissue aspiration device, such as a flexible needle, a cytology brush, or a similar device. The operating tool may include a lumen communicating with a corresponding lumen within the first portion of the actuator portion of the handle.

[0031] For further reference, such as Figure 2 As shown, the multilumen catheter device 14 includes a flexible multilumen sheath with an inner liner 20, the inner liner 20 including a proximal portion 52 and a distal ramp section 50. The proximal portion 52 is attached proximally to a handle (not shown) of the multilumen catheter device 14, and the distal ramp section 50 extends distally from the distal end of the proximal portion 52. The distal ramp section 50 and a small portion of the proximal portion 52 adjacent to the distal ramp section 50 are received within a cap section 60.

[0032] The cap section 60 includes a proximal chamfer section 62 and a distal cap section 70. The proximal end of the proximal chamfer section 62 is attached to a multi-lumen sheath. The multi-lumen sheath 22 receives the inner lining 20 and extends from the handle of the multi-lumen catheter assembly 14. The proximal chamfer section 62 includes a first lumen 68, the proximal end of which mates with the inner lumen of the multi-lumen sheath when attached to the multi-lumen sheath 22. The first lumen 68 includes a chamfer 63 that attaches the proximal end of the first lumen 68 to the outlet port 64 of the proximal chamfer section 62 of the cap section 60. The first lumen 68 will be described in more detail below. The distal cap section 70 includes two directional pins 54 extending into the proximal chamfer section 62.

[0033] The proximal ramp section 62 also includes a second inner cavity for allowing the imaging device to pass from the handle through the multi-cavity sheath 22 to the distal cap section 70.

[0034] The proximal ramp section 62 includes an insert chamber 66 located distal to the ramp 63 of the first cavity 68. The distal end of the distal ramp section 50 of the cavity liner 20 includes a bendable tab 40. After the distal ramp section 50 is inserted into the proximal ramp section 62 of the cap section 60, the tab 40 is bent into the insert chamber 66. The tab 40 can be sized to exert frictional force against the wall of the insert chamber 66. After the tab 40 is bent in the insert chamber, a medical-grade adhesive can be inserted into the insert chamber 66.

[0035] In various implementation schemes, such as Figure 3 and Figure 4 As shown, the illustrative cavity lining includes a distal ramp section 80 attached to a proximal section 82. Both the distal ramp section 80 and the proximal section 82 can be formed of a medical-grade metal, such as stainless steel, nickel-titanium alloy, or similar materials. The proximal section 82 can be tubular in shape and may include a relief (not shown) for improved flexibility. The distal ramp section 80 is grooved. The distal ramp section 80 includes a flexible section 84 and a straight ramp section 86. The flexible section 84 includes curved clearance features, such as laser or machined notches, to allow the distal ramp section 80 to bend at the location of the flexible section 84. The number and type of curved clearance features used in the flexible section 84 can be selected from any number of variations to produce desired flexibility and radius of curvature.

[0036] The straight ramp section 86 extends distally from the flexible section 84. The distal end of the straight ramp section 86 includes a tongue 100 attached via a neck section 90. The neck section 90 may be partially defined by a slit longitudinally inserted into the distal end of the straight ramp section 86. The shape and length of the neck section 90 are chosen to allow the manufacturer to easily bend the tongue 100 into the insert chamber, for example... Figure 2The insert chamber 66 shown.

[0037] In various embodiments, the top edge of the distal end of the proximal segment 82 includes a gap cut 106. The gap cut 106 is designed to reduce friction with the medical device as it passes back and forth through the proximal segment 82 and to deflect at the leading edge of the flexible segment 84 through the exit port.

[0038] In various implementation schemes, such as Figure 5 and Figure 6 As shown, the ramp section 182 of the distal cap segment of the multi-lumen catheter device is molded or formed to include a ramp 184 extending from near the proximal opening 188 of the lumen of the cap segment. The ramp 184 includes an adhesive gap 186 positioned along the top surface of the ramp 184, closer to the distal end of the ramp 184 than the proximal end. An insert chamber 166 is positioned distally relative to the distal end of the ramp 184. The ramp 184 and the insert chamber 166 are exposed to the environment surrounding the ramp section 182 via an outlet port.

[0039] In various embodiments, before the distal end of the cavity liner 180 is inserted into the ramp section 182, the distal end of the cavity liner 180 can be pre-bent to a desired angle to conform to the ramp 184. Additionally, before the distal end of the cavity liner 180 is inserted into the ramp section 182, adhesive 196 can be applied to the ramp 184 on either side of the adhesive gap 186. The adhesive gap 186 allows space between the ramp and the cavity liner 180 for a layer of adhesive 196. If the cavity liner 180 is straight when inserted into the ramp section 182, then the curved gap features, as described above... Figure 3 and Figure 4 Those shown and described allow the inner cavity liner 180 to bend according to the angle of the ramp 184. If adhesive gap 186 and adhesive 196 are present, then an adhesive will be formed between the ramp 184 and the distal end of the inner cavity liner 180.

[0040] Once the inner liner 180 is properly positioned within the ramp section 182, the distal tab 194 attached to the distal end of the inner liner 180 is mechanically bent into the insert chamber 166. The insert chamber 166 is then filled with adhesive to form an adhesive insert 190, thereby firmly retaining the tab 194 within the insert chamber 166.

[0041] In various implementation schemes, such as Figure 7As shown, the ramp section 206 of the cap section 208 for the multilumen catheter device includes a ramp 202 that engages with the distal end of the lumen liner 200. The ramp 202 includes a deeper groove section 204 positioned along a portion of the ramp 202. The deeper groove section 204 is used to receive adhesive prior to insertion into the distal end of the lumen liner 200.

[0042] In various implementation schemes, such as Figure 8 As shown, the ramp section 226 of the cap section 218 for a multi-lumen catheter device includes a ramp 219, an insert chamber 222 positioned distally relative to the ramp 219, a pin lumen 224, and a locking pin 220. The pin lumen 224 connects between the distal side of the ramp section 226 and the distal wall within the insert chamber 222. After the lumen liner 212 with a distal tab 214 is inserted into the ramp section 226, the tab 214 is mechanically bent into the insert chamber 222, similar to the other tabs described above. After bending the tab 214, the locking pin 220 is inserted into the pin lumen 224 such that the proximal end of the locking pin 220 protrudes into the insert chamber 222. The locking pin 220 provides a locking mechanism for the tab 214. At this point, adhesive can be inserted into the insert chamber 222, surrounding the tab 214 and the locking pin 220.

[0043] In various implementation schemes, such as Figure 9 As shown, the cap section 260 of the multi-lumen catheter device includes a ramp section 264 comprising an insert chamber 262 for receiving the distal end of the inner lining 252 and an associated distal tab 254. After the tab 254 is bent into the insert chamber 262, a pin 266 is inserted into the insert chamber 262. The pin 266 includes a pointed distal end. Therefore, when the pin 266 is forcefully inserted into the insert chamber 262, the pointed distal end can be partially or completely embedded in the distal wall of the insert chamber 262. The pin 266 provides a locking mechanism for the tab 254. After the pin 266 is inserted, adhesive can be inserted into the insert chamber 262, surrounding the tab 254 and the pin 266.

[0044] In various implementation schemes, such as Figure 10As shown, the ramp section 268 of the cap section 267 of the multi-lumen catheter device includes a ramp and an insert chamber 262 for receiving the distal end of the lumen liner 270 and an associated elongated distal tongue 272 extending therefrom. The ramp section 268 also includes a tongue receiving area 274 positioned distally relative to the insert chamber 262. The tongue receiving area 274 may comprise a material softer than the material used to form the cap section 267. The tongue receiving area 274 may also include an additional lumen or permeable wall. The elongated distal tongue 272 has a length greater than the length of the insert chamber 262. Once the lumen liner 270 is inserted into the desired position within the ramp section 268, the elongated distal tongue 272 is bent into the insert chamber 262 and the tongue receiving area 274. The elongated distal tongue 272 provides a locking mechanism for the lumen liner 270. After the elongated distal tongue 272 is inserted, adhesive can be inserted into the insert chamber 262 around the tongue 272.

[0045] like Figure 11 As shown, in various embodiments, method 290 illustrates the operational steps for creating one or more dual-lumen catheter devices shown and described above. First, at block 292, the distal end of the lumen liner is inserted into the ramp section of the distal cap component for the dual-lumen catheter. In various embodiments, the lumen liner may need to be pre-bent before insertion into the ramp section. Next, at block 294, the ramp section of the distal end of the lumen liner is secured to the cap section. At block 296, the proximal end of the lumen liner is inserted into the lumen of the multi-lumen sheath. Then, at block 298, the proximal end of the distal cap component is attached to the distal end of the multi-lumen sheath. Attachment of the distal cap component to the multi-lumen sheath can be accomplished using various adhesives or by applying heat-shrinkable material around the component.

[0046] Based on the foregoing discussion and associated illustrations, it is understood that various embodiments have been disclosed and illustrated. Therefore, without any implied limitation (which should not be inferred), the following paragraphs summarize the various embodiments disclosed herein by way of example only and not limitation:

[0047] A. An apparatus comprising: a multi-cavity sheath; a cap having a proximal end attachable to a distal end of the multi-cavity sheath; and a liner comprising: a flexible proximal section; and a distal ramp section having a C-shaped cross-section, the distal ramp section being configured to extend distally from the flexible proximal section and be received by the cap.

[0048] B. The device according to A, wherein: the cap further comprises: a ramp section having a ramp and an outlet port, the ramp being configured to allow a medical device to travel from the liner to the outlet port; an imaging section disposed distally from the ramp section and configured to receive an imaging device; and a distal ramp section including a longitudinal axis having a radius of curvature along at least a portion of the distal ramp section.

[0049] C. The device according to B, wherein: the cap further includes a socket disposed at the distal end of the slope; and the liner further includes a tab disposed distally from the distal slope section, the tab being configured to be received in the socket.

[0050] D. The device according to C, wherein the lining further includes a neck section disposed between the distal ramp section and the tongue.

[0051] E. The device according to D, wherein the tongue includes a first dimension, the neck segment includes a second dimension, the first dimension and the second dimension are perpendicular to the longitudinal axis of the distal ramp segment, and the first dimension is larger than the second dimension.

[0052] F. According to the device described in A, the distal ramp section further includes a bent section and a straight section.

[0053] G. The device according to F, wherein the bent section includes a bending gap feature.

[0054] H. The device according to G, wherein the bending gap feature includes a plurality of laser cuts.

[0055] I. The device according to C, wherein the cap further includes an adhesive capable of receiving the socket.

[0056] J. A system comprising: a medical device; and a multi-cavity device including: a handle including: at least two cavities; a first port communicating with a first cavity of the at least two cavities; and a second port communicating with a second cavity of the at least two cavities, the second port and the second cavity of the at least two cavities being configured to slidably receive a portion of the medical device; a multi-cavity sheath attachable to the handle; a cap having a proximal end attachable to a distal end of the multi-cavity sheath; and a liner including: a flexible proximal section; and a distal ramp section having a C-shaped cross-section, the distal ramp section being configured to extend distally from the flexible proximal section and be received by the cap.

[0057] K. The system according to J, wherein: the cap further includes: a ramp section having a ramp and an outlet port, the ramp being configured to allow a medical device to travel from the liner to the outlet port; and an imaging section disposed distally from the ramp section and configured to receive an imaging device; the distal ramp section including a longitudinal axis having a radius of curvature along at least a portion of the distal ramp section.

[0058] L. The system according to K, wherein: the cap further includes a socket disposed at the distal end of the slope; and the lining further includes a tab disposed distally from the distal slope section, the tab being configured to be received in the socket.

[0059] According to the system described in M.L., the lining further includes a neck section disposed between the distal ramp section and the tongue.

[0060] N. The system according to M, wherein the tongue includes a first dimension, the neck segment includes a second dimension, the first dimension and the second dimension are perpendicular to the longitudinal axis of the distal slope segment, and the first dimension is larger than the second dimension.

[0061] O. According to the system described in J, the distal slope section further includes a bending section and a straight section.

[0062] P. According to the system described in O, the bent section includes a bending gap feature.

[0063] Q. According to the system described in P, the bending gap feature includes multiple laser cuts.

[0064] R. According to the device described in L, the cap further includes an adhesive capable of receiving adhesive in the socket.

[0065] S. A method comprising: providing: a multi-cavity sheath; a cap having a proximal end attachable to a distal end of the multi-cavity sheath, the cap including: a ramp section having a ramp and an outlet port; and an imaging section disposed distally from the ramp section; and a liner including: a flexible proximal section; and a distal ramp section having a C-shaped cross-section; inserting the distal ramp section into the cap; securing the distal ramp section into the cap; inserting the proximal end of the liner into an inner cavity of the multi-cavity sheath; and securing the proximal end of the cap to the distal end of the multi-cavity sheath.

[0066] T. The method according to S further includes performing an action selected from bending the distal slope segment and reducing the bending force of the distal slope segment before inserting the distal slope segment into the cap.

[0067] In some cases, one or more components may be referred to herein as “configured as,” “configurable as,” “operable / operational as,” “adaptable / able to adapt,” “capable of,” “compliant / formable as,” etc. Those skilled in the art will recognize that these terms (e.g., “configured as”) generally cover components in an active state and / or an inactive state and / or a standby state, unless the context requires otherwise.

[0068] While specific aspects of the subject matter described herein have been shown and described, it will be apparent to those skilled in the art that, based on the teachings herein, changes and modifications can be made without departing from the subject matter described herein and its broader aspects. Therefore, the appended claims will be included within their scope as they are within the true principles and scope of the subject matter described herein. Those skilled in the art will understand that, in general, the terminology used herein, particularly in the appended claims (e.g., in the body of the appended claims), is often used as “open” terms (e.g., the term “comprising” should be interpreted as “including but not limited to,” the term “having” should be interpreted as “at least having,” the term “comprising” should be interpreted as “including but not limited to,” etc.). Those skilled in the art will further understand that if a specific number in the statement of an introduced claim is intended, such intention will be expressly stated in the claim, and where there is no such statement, there is no such intention. For example, to aid understanding, the appended claims may contain the use of introductory phrases “at least one” and “one or more” to introduce the statement of the claim. However, the use of these phrases should not be construed as implying that any particular claim containing such an introductory claim is limited to those that are stated in this way, even when the same claim includes the introductory phrases "one or more" or "at least one" and indefinite articles such as "one" or "an" (e.g., "one" and / or "an" should generally be interpreted as "at least one" or "one or more"); the same applies to statements that use definite articles to introduce claims. Furthermore, even when a specific number of introductory claims is explicitly stated, those skilled in the art will recognize that such a statement should generally be interpreted as referring to at least the number stated (e.g., a direct statement of "two statements" without other modifiers generally refers to at least two statements, or two or more statements). Furthermore, in cases where conventions such as "at least one of A, B, and C" are used, such a structure is generally understood by those skilled in the art to be in the sense of the convention (e.g., "a system having at least one of A, B, and C" will include, but is not limited to, systems having A alone, having B alone, having C alone, having A and B, having A and C, having B and C, and / or having A, B, and C, etc.). Those skilled in the art will further understand that, whether in the specification, claims, or drawings, non-connecting words and / or phrases that typically present two or more alternative terms should be understood to account for the possibility of including one, one, or both terms, unless the context otherwise specifies. For example, the phrase "A or B" is generally understood to include the possibility of including "A" or "B" or "A and B".

[0069] Regarding the appended claims, those skilled in the art will understand that the operations described herein can generally be performed in any order. Furthermore, although the various operational flows are presented sequentially, it should be understood that the various operations can be performed in other orders than those illustrated, or can be performed simultaneously. Examples of such alternative orders may include overlapping, interleaving, interruption, reordering, incrementing, preparation, supplementation, simultaneous, reverse, or other different orders, unless the context otherwise specifies. Moreover, terms such as “in response to,” “related to,” or other past tense adjectives are generally not intended to exclude such variations, unless the context otherwise specifies.

[0070] Although the disclosed subject matter has been described with illustrative embodiments, those skilled in the art will understand that various modifications can be made thereto without departing from the scope of the claims as set forth in the claims.

Claims

1. An apparatus for harvesting a tissue sample, comprising: a multi-lumen sheath; a cap having a proximal end attachable to a distal end of the multi-lumen sheath; and a liner comprising: a flexible tubular proximal section; and a distal ramp section having a C-shaped cross-section configured to extend distally from the flexible tubular proximal section and receivable by the cap, wherein the liner further comprises a tab disposed distally from the distal ramp section of the liner and configured to be receivable in a socket of the cap disposed distally from a ramp of the proximal ramp section of the cap.

2. The apparatus of claim 1, wherein: the proximal ramp section of the cap further has an exit port, the ramp of the proximal ramp section of the cap configured to allow a medical device to travel from within the liner to the exit port; the cap further comprises an imaging section disposed distally from the proximal ramp section of the cap and configured to receive an imaging device; and the distal ramp section of the liner comprises a longitudinal axis having a radius of curvature along at least a portion of the distal ramp section of the liner.

3. The apparatus of claim 1, wherein the liner further comprises a neck section disposed between the distal ramp section of the liner and the tab. the tab comprises a first dimension, the neck section comprises a second dimension, the first dimension and the second dimension being perpendicular to a longitudinal axis of the distal ramp section of the liner, the first dimension being greater than the second dimension.

5. The apparatus of claim 1, wherein the distal ramp section of the liner further comprises a bend section and a straight section, wherein the bend section comprises a bend gap feature having a plurality of laser cuts.

4. The apparatus of claim 3, wherein, 6. A system for harvesting a tissue sample, comprising: a medical device; and a multi-lumen device comprising: a handle comprising: at least two lumens; a first port in communication with a first lumen of the at least two lumens; and a second port in communication with a second lumen of the at least two lumens, the second port and the second lumen of the at least two lumens configured to slidably receive a portion of the medical device; a multi-lumen sheath attachable to the handle; a cap having a proximal end attachable to a distal end of the multi-lumen sheath; and a liner comprising: a flexible tubular proximal section; and a distal ramp section having a C-shaped cross-section configured to extend distally from the flexible tubular proximal section and receivable by the cap; wherein the liner further comprises a tab disposed distally from the distal ramp section of the liner and configured to be receivable in a socket of the cap disposed distally from a ramp of the proximal ramp section of the cap.

7. The system of claim 6, wherein: ​ ​ The proximal ramp section of the cap also has an exit port, the ramp of the proximal ramp section of the cap configured to allow a medical device to travel from within the liner to the exit port; The cap also includes an imaging section, the imaging section disposed distally from the proximal ramp section of the cap and configured to receive an imaging device; and The distal ramp section of the liner includes a longitudinal axis, the longitudinal axis having a radius of curvature along at least a portion of the distal ramp section of the liner.

8. The system of claim 6, wherein: The liner also includes a neck section, the neck section disposed between the distal ramp section of the liner and the tab, wherein the tab includes a first dimension, the neck section includes a second dimension, the first and second dimensions being perpendicular to the longitudinal axis of the distal ramp section of the liner, the first dimension being greater than the second dimension.

9. The system of claim 6, wherein the distal ramp section of the liner further includes a bent section and a straight section, wherein the bent section includes a bend gap feature, wherein the bend gap feature includes a plurality of laser cuts.

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