Method for evaluating local or systemic bone density by bioimpedance technology

Abstract

The present invention discloses a method for evaluating local or whole-body bone mineral density by bioimpedance technology, which includes: step (a) measuring the resistance and reactance of a subject by a bioimpedance measuring instrument, and obtaining the height of the subject; step (b) the local or whole-body bone mineral density of the subject is calculated by the following calculation formula: BMD = a + b R / H + d Xc / H, where a, b, and d are weight coefficients; R is the resistance of the subject; Xc is the reactance of the subject; H is the height of the subject, and BMD is the bone mineral density, thereby achieving the advantages of reducing measurement costs and fast measurement.

Description

Technical Field

[0001] The present invention relates to the field of bone density assessment technology, and in particular to a method for assessing local or whole body bone density using bioimpedance technology. Background Art

[0002] Most bone mass examination methods currently use dual energy X-ray absorptiometry (DXA) to measure bone mass (g / cm 2 ) is widely accepted to express bone mineral density (BMD).

[0003] However, although the DXA method for measuring BMD is accepted by everyone, it is expensive and must be measured in a hospital or related professional institution, so it cannot be used in home health care. In addition, each DXA measurement takes dozens of minutes. Therefore, the current DXA method for measuring bone density is costly and time-consuming, and is not convenient to use. Summary of the invention

[0004] 1. Technical issues to be resolved

[0005] The main purpose of the present invention is to provide a method for evaluating local or whole-body bone density using bioimpedance technology. Compared with the prior art, the present invention is low-cost, fast, and easy to use.

[0006] (II) Technical solution

[0007] In order to achieve the above-mentioned purpose, the present invention provides a method for evaluating local or whole body bone density using bioimpedance technology, which comprises the following steps:

[0008] Step (a) is to measure the resistance (R) and reactance (Xc) of a subject by a bioimpedance meter, and obtain the height of the subject.

[0009] Step (b), the local or whole body bone density of the subject is calculated by the following calculation formula:

[0010] BMD=a+b R / H+d Xc / H, wherein a, b, d are weight coefficients; R is the resistance of the subject; Xc is the reactance of the subject; and H is the height of the subject.

[0011] (III) Beneficial effects

[0012] Therefore, the method for evaluating local or whole-body bone density by bioimpedance technology provided by the present invention can measure the bone density only by obtaining the resistance, reactance, and height of the subject through a bioimpedance measuring instrument and then calculating through the calculation formula BMD = a + bR / H + dXc / H. Compared with the prior art, the present invention has low cost, is fast, and has convenience in use. Description of the Drawings

[0013] Figure 1 It is a flowchart of a preferred embodiment of the present invention.

[0014] Figure 2 It is a block diagram of a preferred embodiment of the present invention.

[0015] Figure 3 It is a GLM regression analysis diagram of a preferred embodiment of the present invention.

[0016] Description of the Reference Numerals:

[0017] 10: Method for evaluating local or whole-body bone density by bioimpedance technology

[0018] 20: Bioimpedance measuring instrument

[0019] 21: Electrode group

[0020] 23: Sensing electrode

[0021] 25: Current electrode Detailed Description of the Preferred Embodiment

[0022] In order to illustrate in detail the technical features of the present invention, the following preferred embodiment is now described in conjunction with Figures 1 to 3 as follows: The method 10 for evaluating local or whole-body bone density by bioimpedance technology of the present invention includes (as Figure 1 shown):

[0023] Step (a), measuring the resistance and reactance of a subject by a bioimpedance measuring instrument 20 and obtaining the height of the subject.

[0024] In this preferred embodiment, the height of the subject is measured by a height ruler and manually input into the bioimpedance measuring instrument 20. The accuracy of the height ruler is up to 0.5 cm (but not limited thereto), so as to obtain the height most in line with the current situation of the subject and improve the accuracy of the evaluation result of the present invention. In other preferred embodiments, the subject can also directly provide his / her height and transmit it to the bioimpedance measuring instrument 20 in an automatic and wired / wireless manner. Therefore, the selection of the bioimpedance measuring instrument 20 and the method for the bioimpedance measuring instrument 20 to obtain the height of the subject are not limited to this preferred embodiment.

[0025] As Figure 2 shown, in this preferred embodiment, the bioimpedance measuring instrument 20 measures the resistance and reactance of the subject. The subject lies in a supine position for the measurement by the bioimpedance measuring instrument 20, thereby reducing the error of evaluation. And for the multiple electrode groups 21 of the bioimpedance measuring instrument 20, taking two as an example for the number of the multiple electrode groups 21, the multiple electrode groups 21 contact the right hand and the right foot of the subject to form a measurement loop. Each of the electrode groups 21 has a sensing electrode 23 and a current electrode 25, and the sensing electrode 23 and the current electrode 25 are 5 cm apart. Based on the characteristics of bioimpedance measurement, the accuracy of the evaluation of the present invention can be improved thereby; in other preferred embodiments, the subject can also stand for the measurement by the bioimpedance measuring instrument 20, and the multiple electrode groups 21 can also measure by contacting the hands and feet of the subject, right hand to left foot, left hand to right foot, left hand to left foot, etc. respectively. And in the case of different measurement modes, the number of the multiple electrode groups 21 can also exceed two, and the distance between the sensing electrode 23 and the current electrode 25 can also be between 1 cm - 5 cm or 5 cm - 10 cm. Therefore, the number of the multiple electrode groups 21, and the ways of measuring the resistance and reactance of the subject by the bioimpedance measuring instrument 20 are not limited to this preferred embodiment only.

[0026] In this preferred embodiment, the bioimpedance measuring instrument 20 measures the bone mineral density of the whole body (BMD total ), lumbar spine (BMD Ls ), and right upper limb (BMD right arm ) of the subject, a total of three parts. In other preferred embodiments, other parts of the subject can also be selected for measurement according to requirements, and the number of measurement parts of the subject can be increased or decreased according to requirements.

[0027] Step (b), the bone mineral density of the local or whole body of the subject is calculated by the following calculation formula:

[0028] BMD = a + b R / H + d Xc / H, where a, b, and d are weight coefficients; R is the resistance of the subject; Xc is the reactance of the subject; H is the height of the subject.

[0029] In this preferred embodiment, the weight coefficients of a, b, and d are obtained by using DXA and taking the average bone density values of three parts, namely the whole body, lumbar spine, and right upper limb, of hundreds of testers. In other preferred embodiments, the weight coefficients of a, b, and d can also be obtained by measuring with instruments such as a quantitative ultrasound scanner, quantitative computed tomography, or traditional X-ray examination; moreover, other parts of the tester can be selected for measurement as needed, and the measurement parts of the tester can be increased or decreased as needed. Therefore, the instruments and body parts for measuring the tester are not limited to this preferred embodiment only.

[0030] As Figure 3 shown, the results of this preferred embodiment, in terms of the weight coefficients and correlations corresponding to the generalized linear model regression analysis (GLM regression analysis), show that the values of R / H and Xc / H of the tested person have a positive correlation with the values of the whole body, lumbar spine, and right upper limb measured by DXA.

[0031] Thus, it can be proved that a method for evaluating local or whole-body bone density by using bioimpedance technology provided by the present invention can measure the bone density only by obtaining the resistance, reactance, and height of the tested person through a bioimpedance measuring instrument and then calculating through the calculation formula BMD = a + bR / H + dXc / H. Compared with the prior art, the present invention has low cost, is fast, and has convenience in use.

Claims

1. A method for evaluating local or whole-body bone density by bioimpedance technology, comprising the following steps: Step (a), measuring the resistance and reactance of a subject by a bioimpedance measuring instrument, and obtaining the height of the subject; Step (b), calculating the local or whole-body bone density of the subject by the following calculation formula: BMD = a + b R / H + d Xc / H, where, a, b, and d are weight coefficients; R is the resistance of the subject; Xc is the reactance of the subject; H is the height of the subject, and BMD is bone density; Wherein: The weight coefficients of a, b, and d are obtained after measurement by a quantitative ultrasound examination instrument, quantitative computed tomography examination, or traditional X-ray examination.

2. The method for evaluating local or systemic bone mineral density by bioimpedance technology according to claim 1, wherein: In step (a), the bioimpedance measuring instrument measures the resistance and reactance of the subject by forming a measurement circuit with multiple electrode groups of the bioimpedance measuring instrument contacting the hands and feet, both hands, or both feet of the subject. Each of the electrode groups has a sensing electrode and a current electrode, and the sensing electrode and the current electrode are 1 cm to 10 cm apart.

3. The method for evaluating local or systemic bone density by bioimpedance technology according to claim 1, wherein: In step (a), the subject performs the measurement by the bioimpedance measuring instrument in a supine, standing, or sitting position.

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