Chromatographic column perfusion and elution device

Abstract

The present application relates to the technical field of radioactive devices, and provides a chromatography column perfusion and elution device. The chromatography column perfusion and elution device comprises a mounting frame, a fixing seat is arranged on the mounting frame, a mounting seat is arranged below the fixing seat, and the mounting seat is slidably connected to the mounting frame; a chromatography column mounting component, the chromatography column mounting component can be switched between a limited state connected to the mounting seat and a movable state separated from the mounting seat; a perfusion and elution connecting component, which is mounted on the fixing seat; a locking component, which is mounted on the fixing seat, and the locking component is used to switch the perfusion and elution connecting component between a fixed state fixedly connected to the fixing seat and an active state movable relative to the fixing seat. According to the chromatography column perfusion and elution device of the embodiment of the present application, a detachable connection between the chromatography column mounting component and the mounting frame is realized, and the chromatography column can be quickly replaced, and a detachable connection between the perfusion and elution connecting component and the mounting frame is realized, and the perfusion and elution connecting component through which the radioactive solution flows can be quickly replaced.

Description

Technical Field

[0001] The present application relates to the technical field of radioactive devices, and in particular to a chromatography column perfusion and elution device. Background Art

[0002] Radioisotope generator chromatographic columns can provide people with carrier-free, high specific activity and high radioactive concentration short half-life nuclides repeatedly, safely and conveniently, so they are widely used in medicine, industry, scientific research and other fields. The short half-life nuclides obtained from radioisotope generator chromatographic columns can be used directly or made into a variety of labeled compounds (including drugs) for application. Among the existing radioisotope generator chromatographic columns, the most commonly used are 99 Mo- 99m Tc generator chromatographic column. 99 Mo- 99m The eluent of the Tc generator column is various 99m Tc drugs have been widely used in scanning imaging and functional examinations of the brain, thyroid, salivary glands, lungs, heart, blood, liver, gallbladder, spleen, kidneys, bones, and bone marrow.

[0003] During the production process, the chromatographic column needs to go through the steps of perfusion and elution, that is, the radioactive solution is perfused into the chromatographic column to contact the adsorbent, so that the adsorbent carries the radioactivity, and then eluted. In the related art, when the chromatographic column is perfused and eluted, it is difficult to quickly replace the parts through which the radioactive solution flows, and it takes a lot of time to install the chromatographic column, resulting in the inability to quickly perform the perfusion and elution of the chromatographic column. Summary of the invention

[0004] The present application aims to solve at least one of the technical problems existing in the related art. To this end, the present application proposes a chromatographic column perfusion and elution device, which realizes the detachable connection between the chromatographic column mounting component and the mounting frame, and by using the chromatographic column mounting component to load the chromatographic column, the chromatographic column can be installed on the chromatographic column mounting component in advance, and the chromatographic column can be quickly replaced, and the detachable connection between the perfusion and elution connecting component and the mounting frame can be realized, and the perfusion and elution connecting component through which the radioactive solution flows can be quickly replaced, which saves time and improves the efficiency of the perfusion and elution of the chromatographic column.

[0005] The chromatography column perfusion and elution device according to the embodiment of the present application includes:

[0006] A mounting frame, wherein a fixing seat is disposed on the mounting frame, a mounting seat is disposed below the fixing seat, and the mounting seat is slidably connected to the mounting frame;

[0007] A chromatographic column installation component, used for loading a chromatographic column, wherein the chromatographic column installation component can be switched between a limited state connected to the installation seat and a moving state separated from the installation seat;

[0008] A perfusion and elution connecting component is installed on the fixing seat;

[0009] A locking component is mounted on the fixing seat, and is used to switch the perfusion and elution connecting component between a fixed state in which the perfusion and elution connecting component is fixedly connected to the fixing seat and an active state in which the perfusion and elution connecting component can move relative to the fixing seat.

[0010] According to the chromatography column perfusion and elution device of the embodiment of the present application, a detachable connection between the chromatography column mounting component and the mounting frame is realized. By using the chromatography column mounting component to load the chromatography column, the chromatography column can be installed on the chromatography column mounting component in advance, and the chromatography column can be quickly replaced. The detachable connection between the perfusion and elution connecting component and the mounting frame is realized, and the perfusion and elution connecting component through which the radioactive solution flows can be quickly replaced, which saves time and improves the efficiency of the perfusion and elution of the chromatography column.

[0011] According to an embodiment of the present application, a driving component is provided on the mounting frame, the driving component is located below the mounting seat and connected to the mounting seat, and the driving component is used to drive the mounting seat to slide along the mounting frame.

[0012] According to one embodiment of the present application, an elastic member is provided between the fixing seat and the mounting seat.

[0013] According to an embodiment of the present application, the chromatography column perfusion and elution device includes a quick connection assembly, and the fixing seat is provided with a second mounting groove matching the quick connection assembly, and the quick connection assembly is used to connect the perfusion and elution connecting component and the pipeline.

[0014] According to an embodiment of the present application, a stopper is provided on the fixing seat, and the stopper is located above the second mounting groove.

[0015] According to one embodiment of the present application, a partition seat is provided on the fixing seat, and the partition seat is located below the quick connection assembly.

[0016] According to one embodiment of the present application, the chromatography column perfusion and elution device comprises a perfusion and elution rack, on which a solution delivery assembly located above the mounting frame is disposed, and the solution delivery assembly moves relative to the perfusion and elution rack.

[0017] According to one embodiment of the present application, the solution delivery assembly includes a vertical plate and two infusion connectors, one end of the vertical plate is connected to the perfusion and elution rack, and the other end of the vertical plate is provided with two side panels, and the side panels are provided with U-shaped openings matching the infusion connectors.

[0018] According to an embodiment of the present application, one end of the side panel is connected to the vertical panel, and the other end of the side panel is inclined away from the vertical panel.

[0019] According to an embodiment of the present application, the chromatogram column installation component includes a tray, a plurality of first installation slots are provided on the tray, a snap-in limiting structure is provided on the first installation slot, and the snap-in limiting structure is used to limit the chromatogram column so that the chromatogram column is installed in the first installation slot.

[0020] According to an embodiment of the present application, the clamping limiting structure includes a first limiting plate and a plurality of first limiting blocks arranged on the first mounting groove, and a gap matching the color layer column is arranged between the first limiting plate and the first limiting blocks.

[0021] According to one embodiment of the present application, the perfusion and elution connecting component includes a mounting plate, a first sealing connector, a container, a second sealing connector, a connecting pipe and a quick connecting joint, the first sealing connector and the container are respectively installed on both sides of the mounting plate, the container is connected to the first sealing connector, the second sealing connector is installed on the mounting plate, the second sealing connector and the first sealing connector are located on the same side, and the connecting pipe connects the second sealing connector and the quick connecting joint.

[0022] Additional aspects and advantages of the present application will be given in part in the description below, and in part will become apparent from the description below, or will be learned through the practice of the present application. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] In order to more clearly illustrate the technical solutions in the embodiments of the present application or the related technologies, the drawings required for use in the embodiments or the related technical descriptions are briefly introduced below. Obviously, the drawings described below are only some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0024] Figure 1 This is one of the structural schematic diagrams of the chromatography column perfusion and elution device provided in the embodiments of the present application;

[0025] Figure 2 This is the second structural schematic diagram of the chromatography column perfusion and elution device provided in the embodiment of the present application;

[0026] Figure 3 This is one of the partial structural enlarged schematic diagrams of the chromatography column perfusion and elution device provided in the embodiment of the present application;

[0027] Figure 4 This is the third structural schematic diagram of the chromatography column perfusion and elution device provided in the embodiment of the present application;

[0028] Figure 5 This is the second enlarged schematic diagram of the local structure of the chromatography column perfusion and elution device provided in the embodiment of the present application;

[0029] Figure 6 It is a structural schematic diagram of a chromatographic column installation component of a chromatographic column perfusion and elution device provided in an embodiment of the present application;

[0030] Figure 7 This is the fourth structural schematic diagram of the chromatography column perfusion and elution device provided in the embodiment of the present application;

[0031] Figure 8 This is one of the structural schematic diagrams of the perfusion and elution connecting components of the chromatography column perfusion and elution device provided in the embodiment of the present application;

[0032] Fig. 9 This is the second structural schematic diagram of the perfusion and elution connecting component of the chromatography column perfusion and elution device provided in the embodiment of the present application;

[0033] Fig.10 This is the fifth structural schematic diagram of the chromatography column perfusion and elution device provided in the embodiment of the present application;

[0034] Fig.11 It is a schematic diagram of the structural decomposition of the chromatography column perfusion and elution device provided in an embodiment of the present application;

[0035] Reference numerals:

[0036] 4. Mounting frame; 41. Fixing seat; 42. Mounting seat; 43: Driving component; 44: Elasticity;

[0037] 45: quick connection assembly; 46: stopper; 48: perfusion and elution rack; 49: solution delivery assembly;

[0038] 411: separator seat; 412: fifth groove; 413: fourth through hole; 421: second groove;

[0039] 422, second baffle; 423, first connecting assembly; 424: first inclined surface; 451: quick mounting plate;

[0040] 452: quick connector; 491: vertical plate; 492: infusion connector; 493: side plate; 494: U-shaped port;

[0041] 5: color layer column installation component; 51: tray; 511: first installation slot; 512: clamping limit structure;

[0042] 513: first limiting plate; 514: first limiting block; 515: first arc surface; 516: second arc surface;

[0043] 517, first clamping portion; 518, first baffle; 519: second protrusion; 510: first groove;

[0044] 6: perfusion and elution connecting component; 61: mounting plate; 62: first sealing connector; 63: container;

[0045] 64: second sealing connector; 65: connecting pipe; 66: quick-connect connector; 67: first connecting piece;

[0046] 68: second connecting member; 611: third groove; 612: first through hole; 613: fixing plate;

[0047] 614: fourth groove; 615: second clamping portion;

[0048] 7: Locking part; 71, elbow clamp. DETAILED DESCRIPTION

[0049] The following is a further detailed description of the implementation of the present application in conjunction with the accompanying drawings and examples. The following examples are used to illustrate the present application but cannot be used to limit the scope of the present application.

[0050] In the description of the embodiments of the present application, it should be noted that the terms "center", "longitudinal", "lateral", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside" and the like indicate positions or positional relationships based on the positions or positional relationships shown in the accompanying drawings, which are only for the convenience of describing the embodiments of the present application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as limiting the embodiments of the present application. In addition, the terms "first", "second", and "third" are used for descriptive purposes only and cannot be understood as indicating or implying relative importance.

[0051] In the description of the embodiments of the present application, it should be noted that, unless otherwise clearly specified and limited, the terms "connected" and "connection" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be directly connected or indirectly connected through an intermediate medium. For ordinary technicians in this field, the specific meanings of the above terms in the embodiments of the present application can be understood according to specific circumstances.

[0052] In the embodiments of the present application, unless otherwise clearly specified and limited, a first feature being "above" or "below" a second feature may mean that the first and second features are in direct contact, or the first and second features are in indirect contact through an intermediate medium. Moreover, a first feature being "above", "above" or "above" a second feature may mean that the first feature is directly above or obliquely above the second feature, or simply means that the first feature is higher in level than the second feature. A first feature being "below", "below" or "below" a second feature may mean that the first feature is directly below or obliquely below the second feature, or simply means that the first feature is lower in level than the second feature.

[0053] In the description of this specification, the description with reference to the terms "one embodiment", "some embodiments", "example", "specific example", or "some examples" etc. means that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the embodiments of the present application. In this specification, the schematic representations of the above terms do not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described may be combined in any one or more embodiments or examples in a suitable manner. In addition, those skilled in the art may combine and combine the different embodiments or examples described in this specification and the features of the different embodiments or examples, without contradiction.

[0054] Combine the following Figures 1 to 11 The chromatography column perfusion and elution device of the present application is described.

[0055] According to the embodiment of the present application, Figure 1 As shown, the chromatography column infusion and elution device includes:

[0056] A mounting frame 4, wherein a fixing seat 41 is disposed on the mounting frame 4, a mounting seat 42 is disposed below the fixing seat 41, and the mounting seat 42 is slidably connected to the mounting frame 4;

[0057] A chromatographic column mounting component 5, used for loading a chromatographic column, wherein the chromatographic column mounting component 5 can be switched between a limited state connected to the mounting seat 42 and a moving state separated from the mounting seat 42;

[0058] The perfusion and elution connecting component 6 is installed on the fixing seat 41;

[0059] The locking component 7 is mounted on the fixing seat 41 , and is used to switch the perfusion and elution connecting component 6 between a fixed state in which it is fixedly connected to the fixing seat 41 and an active state in which it can move relative to the fixing seat 41 .

[0060] When in use, the chromatographic column is mounted on the chromatographic column mounting component 5, and then the chromatographic column mounting component 5 is mounted on the mounting seat 42 by a mechanical device such as a manipulator, so that the chromatographic column mounting component 5 is in a limited state connected with the mounting seat 42, and then the chromatographic column is mounted on the mounting frame 4. The perfusion and elution connecting component 6 is mounted on the fixing seat 41 by a mechanical device such as a manipulator, and then the perfusion and elution connecting component 6 is in a fixed state fixedly connected with the fixing seat 41 by a locking component 7. Then, an external force is applied to the mounting seat 42, so that the mounting seat 42 moves toward the fixing seat 41, and the chromatographic column on the mounting seat 42 moves accordingly, so that the chromatographic column is connected with the perfusion and elution connecting component 6 on the fixing seat 41, and then the radioactive solution and eluent are transported into the chromatographic column through the perfusion and elution connecting component 6, so as to realize the perfusion and elution operation of the chromatographic column.

[0061] When the perfusion and elution operation of the chromatographic column is completed, an external force is applied to the chromatographic column installation component 5 by a mechanical device such as a manipulator, so that the chromatographic column installation component 5 is in a moving state away from the mounting seat 42, and then the chromatographic column installation component 5 and the chromatographic column on the chromatographic column installation component 5 can be quickly replaced. Then, the locking component 7 is controlled by a mechanical device such as a manipulator, and the perfusion and elution connecting component 6 is in an active state that can move relative to the fixed seat 41 through the locking component 7, and then the perfusion and elution connecting component 6 can be quickly replaced. In this way, the detachable connection between the chromatographic column installation component 5 and the mounting frame 4 is realized. By using the chromatographic column installation component 5 to load the chromatographic column, the chromatographic column can be installed on the chromatographic column installation component 5 in advance, and the chromatographic column can be quickly replaced, and the detachable connection between the perfusion and elution connecting component 6 and the mounting frame 4 is realized. The perfusion and elution connecting component 6 through which the radioactive solution flows can be quickly replaced, saving time and improving the efficiency of the perfusion and elution of the chromatographic column.

[0062] In one embodiment of the present application, Figure 1As shown, the mounting frame 4 is provided with a driving component 43, the driving component 43 is located below the mounting seat 42 and connected to the mounting seat 42, and the driving component 43 is used to drive the mounting seat 42 to slide along the mounting frame 4. When in use, the chromatographic column mounting component 5 is first mounted on the mounting seat 42, and the perfusion and elution connecting component 6 is mounted on the fixed seat 41, and then the mounting seat 42 is driven to move toward the fixed seat 41 by the driving component 43, and the chromatographic column mounting component 5 on the mounting seat 42 moves accordingly, so that the chromatographic column on the chromatographic column mounting component 5 is connected to the perfusion and elution connecting component 6, and then the perfusion and elution operation of the chromatographic column can be performed. After the perfusion and elution operation of the chromatographic column is completed, the driving component 43 drives the chromatographic column mounting component 5 away from the fixed seat 41, so that the chromatographic column on the chromatographic column mounting component 5 is out of contact with the perfusion and elution connecting component 6, and then the chromatographic column mounting component 5 and the chromatographic column on the chromatographic column mounting component 5 can be quickly replaced by mechanical equipment such as a manipulator.

[0063] In the embodiment of the present application, the driving component 43 is, for example, a driving cylinder, which avoids the use of electrical components, increases the service life of the driving component 43, and avoids the problem of short service life of the driving component 43 caused by radioactive corrosion of electrical components. However, it should be understood that the driving component 43 can also be any other suitable power component that can drive the mounting seat 42 to move.

[0064] In one embodiment of the present application, Figure 2 As shown, an elastic member 44 is provided between the fixing seat 41 and the mounting seat 42. When in use, when the mounting seat 42 moves toward the fixing seat 41, the elastic member 44 is located between the mounting seat 42 and the fixing seat 41, and the elastic member 44 can prevent the mounting seat 42 from directly colliding with the fixing seat 41, and prevent the mounting seat 42 and the color layer column on the mounting seat 42 from directly colliding with the fixing seat 41, thereby effectively avoiding the occurrence of component damage.

[0065] In the embodiment of the present application, the elastic member 44 is, for example, a rubber block, but it should be understood that the elastic member 44 may also be any other suitable structural member.

[0066] In the embodiments of the present application, Figure 3As shown, the chromatographic column perfusion and elution device includes a quick connection component 45, and the fixing seat 41 is provided with a second installation groove matching the quick connection component 45, and the quick connection component 45 is used to connect the perfusion and elution connecting component 6 and the pipeline. When in use, the perfusion and elution connecting component 6 is installed on the fixing seat 41, so that one end of the perfusion and elution connecting component 6 is connected to the chromatographic column, and the quick connection component 45 is installed in the second installation groove, and the other end of the perfusion and elution connecting component 6 is connected to one end of the pipeline through the quick connection component 45, and the other end of the pipeline is connected to a peristaltic pump or a corresponding extraction device, so that the solution in the perfusion and elution connecting component 6 can flow to the pipeline after passing through the chromatographic column through the pipeline, and then be collected.

[0067] In the embodiment of the present application, the pipeline is, for example, a hose, but it should be understood that the pipeline can also be any other suitable connecting pipeline.

[0068] In one embodiment of the present application, Figure 3 As shown, a stopper 46 is provided on the fixing seat 41, and the stopper 46 is located above the second mounting groove. When in use, the quick connection assembly 45 is installed in the second mounting groove, and the stopper 46 can limit the quick connection assembly 45 to prevent the quick connection assembly 45 from being separated from the second mounting groove during the perfusion and elution process of the chromatography column.

[0069] In one embodiment of the present application, Figure 3 As shown, the quick connection assembly 45 includes a quick installation plate 451 and a quick connector 452. The quick connector 452 is installed on the quick installation plate 451. One end of the quick connector 452 is connected to the connector of the perfusion and elution connecting component 6, and the other end of the quick connector 452 is connected to the pipeline. When in use, the quick installation plate 451 is installed in the second installation groove, and then the perfusion and elution connecting component 6 is connected to the pipeline through the quick connector 452, thereby improving the assembly speed.

[0070] In one embodiment of the present application, Figure 3 As shown, a separator 411 is provided on the fixing seat 41, and the separator 411 is located below the quick connection assembly 45. When in use, the quick connection assembly 45 connects the perfusion and elution connecting component 6 and the pipeline. By providing the separator 411 below the quick connection assembly 45, the pipeline will not appear between the fixing seat 41 and the mounting seat 42 when connected to the quick connection assembly 45, and the pipeline is isolated from the area between the fixing seat 41 and the mounting seat 42 by the separator 411, which avoids the pipeline being located between the fixing seat 41 and the mounting seat 42 and affecting the movement of the mounting seat 42 toward the fixing seat 41, thereby ensuring that the perfusion and elution of the chromatographic column can be carried out normally.

[0071] In one embodiment of the present application, Figure 4 and Figure 5 As shown, the chromatographic column perfusion and elution device includes a perfusion and elution rack 48, on which a solution delivery assembly 49 located above the mounting frame 4 is provided, and the solution delivery assembly 49 moves relative to the perfusion and elution rack 48. When in use, the perfusion and elution rack 48 is mounted above the fixing seat 41, and the solution delivery assembly 49 moves along the perfusion and elution rack 48. The solution delivery assembly 49 can deliver the radioactive solution and the eluent to the perfusion and elution connecting component 6, thereby realizing the perfusion and elution operation of the chromatographic column. When operating multiple chromatographic columns at the same time, the solution delivery assembly 49 moves along the perfusion and elution rack 48 to deliver the radioactive solution and the eluent to different chromatographic columns respectively.

[0072] In one embodiment of the present application, Figure 4 and Figure 5 As shown, the solution delivery assembly 49 includes a vertical plate 491 and two infusion connectors 492. One end of the vertical plate 491 is connected to the perfusion and elution rack 48. The other end of the vertical plate 491 is provided with two side plates 493. The side plates 493 are provided with U-shaped openings 494 that match the infusion connectors 492. When in use, the infusion connectors 492 are engaged with the U-shaped openings 494 so that the infusion connectors 492 are located above the perfusion and elution connecting components 6. The two infusion connectors 492 can be moved along the perfusion and elution racks 48 to deliver the radioactive solution and the eluent to the corresponding chromatographic column through the perfusion and elution connecting components 6. When the perfusion and elution of the chromatographic column is completed, the infusion connectors 492 can be directly removed from the U-shaped openings 494 by a manipulator, which is simple and convenient for replacement.

[0073] In one embodiment of the present application, Figure 4 and Figure 5 As shown, one end of the side plate 493 is connected to the vertical plate 491, and the other end of the side plate 493 is inclined toward the end away from the vertical plate 491. When in use, by inclining the side plate 493 toward the end away from the vertical plate 491, the side plate 493 is inclined toward the mounting frame 4, and after the infusion connector 492 is installed on the U-shaped opening 494 on the side plate 493, the distance between the infusion connectors 492 on the two side plates 493 is closer, and the two infusion connectors 492 can be located above the perfusion and elution connecting component 6 at the same time, and the solution can be transported to the perfusion and elution connecting component 6 at the same time. After one of the infusion connectors 492 transports the radioactive solution to the perfusion and elution connecting component 6, the other infusion connector 492 can transport the eluent to the perfusion and elution connecting component 6 without moving, thereby improving efficiency and avoiding the situation where the residual radioactive solution drips due to the movement of the infusion connector 492 that transports the radioactive solution.

[0074] In one embodiment of the present application, Figure 1 and Figure 2 As shown, the locking component 7 includes at least one toggle clamp 71, which is installed on the fixing seat 41. The toggle clamp 71 is used to switch the perfusion and elution connecting component 6 between the fixed state and the active state. When in use, an external force is applied to the toggle clamp 71 by a mechanical device such as a manipulator, so that the toggle clamp 71 switches between a loose state and a locked state. When the toggle clamp 71 is in the loose state, the perfusion and elution connecting component 6 is in the active state, and when the toggle clamp 71 is in the locked state, the perfusion and elution connecting component 6 is in the fixed state, thereby realizing the control of the state switching of the perfusion and elution connecting component 6.

[0075] In one embodiment of the present application, Figure 6 and Figure 7 As shown, the chromatographic column installation component 5 includes a tray 51, on which a plurality of first installation grooves 511 are arranged, and on which the first installation grooves 511 are arranged a clamping limiting structure 512, which is used to limit the chromatographic column so that the chromatographic column is installed in the first installation grooves 511.

[0076] When in use, the chromatographic column is installed on the first installation groove 511 by manual or mechanical equipment before the chromatographic column enters the production chamber, so that the chromatographic column is clamped with the first installation groove 511, and the chromatographic column is limited at the first installation groove 511 by the clamping limiting structure 512, so that the chromatographic column is stably installed on the first installation groove 511. It is realized that the chromatographic column can be installed on the tray 51 in advance, and then the tray 51 is installed in the corresponding production chamber. The chromatographic column is clamped and limited by the clamping limiting structure 512, so that the installation of the chromatographic column is convenient, time is saved, efficiency is improved, and the installation stability of the chromatographic column is effectively improved. After the chromatographic column is installed on the tray 51, the tray 51 and the chromatographic column on the tray 51 can be moved to the corresponding position by mechanical equipment such as a manipulator to clamp the tray 51, so that the chromatographic column can be quickly replaced, and the production efficiency of the chromatographic column is improved. In the embodiment of the present application, a chromatographic column can be installed in each first installation groove 511 , and then a required number of chromatographic columns can be installed on the tray 51 according to actual production requirements.

[0077] In one embodiment of the present application, Figure 6 and Figure 7As shown, the clamping and limiting structure 512 includes a first limiting plate 513 and a plurality of first limiting blocks 514 arranged on the first installation groove 511, and a gap matching the chromatographic column is arranged between the first limiting plate 513 and the first limiting blocks 514. When in use, the chromatographic column is clamped to the gap by manual or mechanical equipment before the chromatographic column enters the production chamber, and the chromatographic column is completely clamped to the gap, and then the chromatographic column is installed in the first installation groove 511, and the chromatographic column is limited by the first limiting plate 513 and the first limiting blocks 514, so that the chromatographic column can be stably installed on the tray 51 to prevent the chromatographic column from shaking. By applying an external force to the chromatographic column, the chromatographic column is gradually separated from the gap, and the chromatographic column can be removed from the tray 51, so that the installation and removal of the chromatographic column is convenient.

[0078] In one embodiment of the present application, Figure 6 and Figure 7 As shown, one or more of the first limiting blocks 514 extend toward the first limiting plate 513 at one end thereof, and the side wall surface of the portion of the first limiting block 514 extending toward the first limiting plate 513 is a first arc surface 515. When in use, the color layer column is clamped with the gap by mechanical equipment such as a manipulator and an external force is applied to the color layer column, so that the color layer column moves along the gap. When the color layer column moves to abut against the extension part of the first limiting block 514, the external force is continuously applied to the color layer column, so that the color layer column moves along the first arc surface 515, so that the color layer column is clamped with the extension part of the first limiting block 514, thereby further improving the stability of the connection between the color layer column and the tray 51.

[0079] In one embodiment of the present application, Figure 6 and Figure 7 As shown, the second arc surface 516 is disposed on both sides of the notch of the first installation slot 511. When in use, when the chromatographic column is moved to the notch of the first installation slot 511 manually or mechanically, since the second arc surface 516 is disposed on both sides of the notch of the first installation slot 511, the chromatographic column can slide toward the first installation slot 511 along the second arc surface 516, so that the chromatographic column can be more easily engaged with the first installation slot 511, thereby improving the efficiency of installing the chromatographic column on the tray 51.

[0080] In one embodiment of the present application, Figure 6 and Figure 7 As shown, the tray 51 is provided with a first clamping portion 517. When in use, by providing the first clamping portion 517 on the tray 51, a clamping device such as a robot can move the tray 51 to a corresponding position by clamping the first clamping portion 517.

[0081] In one embodiment of the present application, Figure 6 and Figure 7 As shown, the first clamping portion 517 includes a first protrusion protruding from the tray 51, and first baffles 518 are provided on both sides of the first protrusion. When in use, by providing the first protrusion at a position protruding from the tray 51, and providing the first baffles 518 on both sides of the first protrusion, a clamping device such as a manipulator clamps the first protrusion, and the manipulator is located between the two first baffles 518. The first baffle 518 can limit the manipulator, prevent the manipulator from falling off when clamping the first protrusion, and ensure that the manipulator can stably clamp the tray 51.

[0082] In one embodiment of the present application, Figure 6 and Figure 7 As shown, the upper parts of both ends of the tray 51 are provided with second protrusions 519, and the lower parts of both ends of the tray 51 are provided with first grooves 510 matching the second protrusions 519. When in use, by providing matching second protrusions 519 and first grooves 510 on the trays 51, the second protrusion 519 of one tray 51 is engaged with the first groove 510 of the other tray 51, so that the two trays 51 are stacked together, saving the placement space of the trays 51, and the engagement of the second protrusions 519 and the first grooves 510 can make the stacking of the two trays 51 more stable and prevent the trays 51 from sliding.

[0083] In one embodiment of the present application, Figure 6 and Figure 7 As shown, the perfusion and elution rack 48 includes a mounting rack 4 and the above-mentioned chromatographic column mounting component 5. The mounting rack 4 is provided with a mounting seat 42, and the mounting seat 42 is provided with a second groove 421 matching the chromatographic column mounting component 5. When in use, the chromatographic column can be installed on the tray 51 in advance, and then the tray 51 can be installed in the corresponding production chamber. The chromatographic column is clamped and limited by the clamping and limiting structure 512, so that the installation of the chromatographic column is convenient, time is saved, efficiency is improved, and the installation stability of the chromatographic column is effectively improved. The chromatographic column mounting component 5 is installed in the second groove 421, and the chromatographic column mounting component 5 is limited by the second groove 421, so that the chromatographic column mounting component 5 can be stably installed on the mounting rack 4.

[0084] In one embodiment of the present application, Figure 6 and Figure 7As shown, the mounting seat 42 is provided with a second baffle 422, the second baffle 422 is located above the second groove 421, and the chromatographic column mounting component 5 is located between the second groove 421 and the second baffle 422. When in use, the chromatographic column mounting component 5 is mounted in the second groove 421, and the chromatographic column mounting component 5 is located between the second groove 421 and the second baffle 422. The second baffle 422 can further limit the chromatographic column mounting component 5, preventing the chromatographic column mounting component 5 from shaking up and down, so that the chromatographic column mounting component 5 is stably mounted in the second groove 421, ensuring that the chromatographic column on the chromatographic column mounting component 5 is also stable, which is convenient for the chromatographic column perfusion and washing.

[0085] In one embodiment of the present application, Figure 6 and Figure 7 As shown, a first connection component 423 is provided at the connection between the chromatogram column installation component 5 and the second groove 421. When in use, the chromatogram column installation component 5 is installed at the second groove 421, and the chromatogram column installation component 5 and the second groove 421 are connected together through the first connection component 423, which further improves the stability of the connection between the chromatogram column installation component 5 and the second groove 421.

[0086] In the embodiment of the present application, the first connection component 423 includes at least one ball lock, one end of which is fixedly connected to the chromatographic column mounting component 5, and the other end of which is fixedly connected to the second groove 421. When in use, the chromatographic column mounting component 5 is mounted to the second groove 421, and one end of the ball lock is brought into contact with the other end of the ball lock to be connected together, thereby connecting the chromatographic column mounting component 5 and the second groove 421 together to prevent the chromatographic column mounting component 5 from shaking and shifting.

[0087] In the embodiments of the present application, Figure 1 and Figure 2 As shown, the first connection component 423 includes a first clamping block and a first clamping groove that cooperate with each other, one of which is arranged on the chromatographic column installation component 5, and the other is arranged on the second groove 421. When in use, the chromatographic column installation component 5 is installed in the second groove 421, and the first clamping block is clamped with the first clamping groove, so that the chromatographic column installation component 5 and the second groove 421 are connected together, thereby improving the stability of the connection between the chromatographic column installation component 5 and the second groove 421.

[0088] In the embodiment of the present application, the first clamping block is, for example, disposed on the color layer column mounting component 5, and the first clamping groove is, for example, disposed on the second groove 421. However, it should be understood that the first clamping block and the first clamping groove may also be disposed at any other suitable position.

[0089] In one embodiment of the present application, Figure 6 and Figure 7 As shown, first inclined surfaces 424 are respectively provided at both ends of the notch of the second groove 421. When in use, the color layer column installation component 5 is clamped and moved to the notch of the second groove 421 by a clamping device such as a manipulator, and then the color layer column installation component 5 is pushed, so that the color layer column installation component 5 moves along the first inclined surface 424 into the second groove 421, so that the color layer column installation component 5 is clamped with the second groove 421. By providing the first inclined surface 424, the color layer column installation component 5 can be more easily clamped with the second groove 421.

[0090] In one embodiment of the present application, Figure 8 , Fig. 9 , Fig.10 and Fig.11 As shown, the perfusion and elution connecting component 6 includes a mounting plate 61, a first sealing connector 62, a container 63, a second sealing connector 64, a connecting pipe 65 and a quick-connect joint 66. The first sealing connector 62 and the container 63 are respectively installed on both sides of the mounting plate 61, the container 63 is connected with the first sealing connector 62, the second sealing connector 64 is installed on the mounting plate 61, the second sealing connector 64 and the first sealing connector 62 are located on the same side, and the connecting pipe 65 connects the second sealing connector 64 and the quick-connect joint 66.

[0091] When in use, the mounting plate 61 is clamped by a manipulator or other suitable equipment, and the perfusion and elution connecting component 6 is installed above the chromatographic column, so that the first sealed connector 62 is connected to the first connection port of the chromatographic column, and the second sealed connector 64 is connected to the second connection port of the chromatographic column, so that the container 63, the first sealed connector 62, the chromatographic column, the second sealed connector 64 and the connecting pipe 65 form a connecting pipeline. Then, the perfusion liquid is injected into the container 63, and the quick connection joint 66 is connected to a vacuum pump or other extraction equipment. The perfusion liquid enters the chromatographic column through the first sealed connector 62 and contacts the adsorbent in the chromatographic column. Then, the perfusion liquid is extracted from the chromatographic column through the second sealed connector 64 and the connecting pipe 65, and the perfusion operation of the chromatographic column is realized. Then, the eluent is injected into the container 63 and the operation is repeated to realize the elution operation of the chromatographic column. Therefore, the chromatographic column can be quickly connected to the perfusion and elution pipelines such as the container 63 and the connecting pipeline 65, so that the perfusion and elution operation of the chromatographic column can be quickly realized, thereby improving the production efficiency of the chromatographic column.

[0092] In one embodiment of the present application, Figure 8 , Fig. 9 , Fig.10 and Fig.11As shown, a first connecting piece 67 is provided between the first sealing connector 62 and the container 63, and the first connecting piece 67 is used to connect the first sealing connector 62 and the container 63. When in use, one end of the first connecting piece 67 is quickly connected to the first sealing connector 62, and the other end of the first connecting piece 67 is quickly connected to the container 63, thereby quickly connecting the first sealing connector 62 and the container 63, thereby improving the assembly efficiency of the first sealing connector 62 and the container 63.

[0093] In the embodiment of the present application, the first connecting member 67 is, for example, a Luer connector, the upper and lower ends of which are both provided with external threads, and the first sealing connector 62 and the container 63 are respectively provided with internal threads matching the external threads on the Luer connector. However, it should be understood that the first connecting member 67 can also be any other suitable structural member that can connect the first sealing connector 62 and the container 63.

[0094] In one embodiment of the present application, Figure 8 , Fig. 9 , Fig.10 and Fig.11 As shown, the mounting plate 61 is provided with a third groove 611, the third groove 611 is provided with a first through hole 612, the first connecting piece 67 is engaged with the third groove 611, one end of the first connecting piece 67 passes through the first through hole 612 and is connected with the first sealing connector 62, and the other end of the first connecting piece 67 is connected with the container 63. When in use, the first sealing connector 62 and the container 63 are quickly connected through the first connecting piece 67, and the first connecting piece 67 is engaged with the mounting plate 61 through the third groove 611, so that the container 63 and the first sealing connector 62 can be quickly fixed on the mounting plate 61, thereby improving the assembly efficiency, and the first sealing connector 62 and the container 63 can stably maintain a state of being connected with the chromatographic column.

[0095] In one embodiment of the present application, Figure 8 , Fig. 9 , Fig.10 and Fig.11 As shown, a fixing plate 613 is provided on the mounting plate 61, and the fixing plate 613 is installed above the third groove 611. A second through hole is provided on the fixing plate 613, and the other end of the first connecting member 67 passes through the second through hole to connect with the container 63. When in use, the first connecting member 67 is first clamped at the third groove 611, and then the fixing plate 613 is installed above the third groove 611 so that the other end of the first connecting member 67 can pass through the second through hole to connect with the container 63. In this way, the first connecting member 67 is further fixed to the mounting plate 61 through the fixing plate 613, so that the first connecting member 67 is more stably installed on the mounting plate 61.

[0096] In one embodiment of the present application, Figure 8 , Fig. 9 , Fig.10 and Fig.11 As shown, a second connecting piece 68 is provided between the second sealing connector 64 and the connecting pipe 65, and the second connecting piece 68 is used to connect the second sealing connector 64 and the connecting pipe 65. When in use, one end of the second connecting piece 68 is quickly connected to the second sealing connector 64, and the other end of the second connecting piece 68 is quickly connected to the connecting pipe 65, thereby quickly connecting the second sealing connector 64 and the connecting pipe 65, thereby improving the assembly efficiency of the second sealing connector 64 and the connecting pipe 65.

[0097] In the embodiment of the present application, the second connecting member 68 is, for example, a Luer connector, one end of the Luer connector connected to the second sealing connector 64 is provided with an external thread, and one end of the Luer connector connected to the connecting pipe 65 is a quick-connect connector. However, it should be understood that the second connecting member 68 can also be any other suitable structural member that can quickly connect the second sealing connector 64 and the connecting pipe 65.

[0098] In the embodiment of the present application, the connecting pipe 65 is, for example, a soft rubber tube, which can be quickly connected to the second connecting member 68 and the quick connecting connector 66. However, it should be understood that the connecting pipe 65 can also be any other suitable connecting structure.

[0099] In one embodiment of the present application, Figure 8 , Fig. 9 , Fig.10 and Fig.11 As shown, the mounting plate 61 is provided with a fourth groove 614 matching the second connecting piece 68, the fourth groove 614 is provided with a third through hole, the second connecting piece 68 is engaged with the fourth groove 614, one end of the second connecting piece 68 passes through the third through hole to connect with the second sealing connector 64, and the other end of the second connecting piece 68 is connected with the connecting pipe 65. When in use, the second connecting piece 68 is engaged with the fourth groove 614, and the two ends of the second connecting piece 68 pass through the third through hole to connect the second sealing connector 64 and the connecting pipe 65. Thus, the second sealing connector 64, the second connecting piece 68 and the connecting pipe 65 are all mounted on the mounting plate 61 quickly and stably, and the second sealing connector 64 and the connecting pipe 65 can be effectively prevented from shaking during the process of perfusion and elution of the chromatographic column.

[0100] In one embodiment of the present application, Figure 8 , Fig. 9 , Fig.10 and Fig.11As shown, the mounting plate 61 is provided with a second clamping portion 615. When in use, by providing the second clamping portion 615 on the mounting plate 61, mechanical equipment such as a manipulator can stably clamp the mounting plate 61 and stably move the mounting plate 61 and the components on the mounting plate 61.

[0101] In one embodiment of the present application, Figure 8 , Fig. 9 , Fig.10 and Fig.11 As shown, the second clamping portion 615 includes a clamping column, which is mounted on the mounting plate 61, and one end of the clamping column away from the mounting plate 61 extends to both sides. When in use, the manipulator or corresponding mechanical equipment clamps the clamping column, and since one end of the clamping column away from the mounting plate 61 extends to both sides, that is, one end of the clamping column away from the mounting plate 61 has protruding blocks protruding to both sides, when the manipulator clamps, the extension of the clamping column to both sides can effectively limit the manipulator, preventing the manipulator from detaching from the clamping column when clamping, and ensuring that the manipulator can stably clamp the mounting plate 61 and move the mounting plate 61 to the corresponding position.

[0102] In one embodiment of the present application, Fig.10 and Fig.11 As shown, the chromatographic column perfusion and elution device includes a mounting frame 4 and the perfusion and elution connecting component 6. The upper part of the mounting frame 4 is provided with a fixing seat 41, and the perfusion and elution connecting component 6 is installed on the fixing seat 41. When in use, the chromatographic column can be quickly connected with the perfusion and elution pipelines such as the container 63 and the connecting pipe 65, and the perfusion and elution operation of the chromatographic column can be quickly realized, thereby improving the production efficiency of the chromatographic column. The perfusion and elution connecting component 6 is installed on the mounting frame 4, and the mounting frame 4 can support the perfusion and elution connecting component 6, so that the perfusion and elution operation of the chromatographic column is more stable and reliable. When the perfusion and elution operation of the chromatographic column is completed, the entire perfusion and elution connecting component 6 can be removed from the mounting frame 4 by clamping the mounting plate 61 by the manipulator. When the chromatographic column needs to be perfused and eluted again, the manipulator clamps a new perfusion and elution connecting component 6 and installs it on the mounting frame 4, thereby realizing the rapid replacement of the perfusion and elution connecting component 6.

[0103] In one embodiment of the present application, Fig.10 and Fig.11As shown, the fixing seat 41 is provided with a fifth groove 412 matching the perfusion and elution communication component 6, and the bottom of the fifth groove 412 is provided with a fourth through hole 413. The perfusion and elution communication component 6 is installed at the fifth groove 412 so that the first sealing connector 62 and the second sealing connector 64 pass through the fourth through hole 413 and are located below the fixing seat 41. When in use, the perfusion and elution communication component 6 is installed at the fifth groove 412 so that the perfusion and elution communication component 6 is engaged with the mounting frame 4, so that the mounting frame 4 can not only support the perfusion and elution communication component 6 but also limit the perfusion and elution communication component 6. The fourth through hole 413 is provided at the fifth groove 412 so that when the perfusion and elution communication component 6 is installed at the fifth groove 412, the first sealing connector 62 and the second sealing connector 64 can pass through the fourth through hole 413 so that the first sealing connector 62 and the second sealing connector 64 can be connected to the chromatographic column respectively.

[0104] Finally, it should be noted that the above implementation modes are only used to illustrate the present application, rather than to limit the present application. Although the present application is described in detail with reference to the embodiments, a person skilled in the art should understand that various combinations, modifications or equivalent substitutions of the technical solutions of the present application do not depart from the spirit and scope of the technical solutions of the present application, and should be included in the scope of the claims of the present application.

Claims

1. A chromatography column perfusion and elution device, characterized in that: include: A mounting frame, wherein a fixing seat is disposed on the mounting frame, a mounting seat is disposed below the fixing seat, and the mounting seat is slidably connected to the mounting frame; A chromatographic column installation component, used for loading a chromatographic column, wherein the chromatographic column installation component can be switched between a limited state connected to the installation seat and a moving state separated from the installation seat; A perfusion and elution connecting component is installed on the fixing seat; a locking component mounted on the fixing seat, the locking component comprising at least one toggle clamp, the toggle clamp being mounted on the fixing seat, the locking component being used to switch the perfusion and elution communication component between a fixed state in which the perfusion and elution communication component is fixedly connected to the fixing seat and a detachably movable state relative to the fixing seat; The chromatography column perfusion and elution device comprises a perfusion and elution rack, on which a solution delivery assembly located above the mounting rack is arranged, and the solution delivery assembly moves relative to the perfusion and elution rack; The solution delivery assembly includes a vertical plate and two infusion connectors, one end of the vertical plate is connected to the perfusion and elution rack, and the other end of the vertical plate is provided with two side plates, and the side plates are provided with U-shaped openings matching the infusion connectors; One end of the side plate is connected to the vertical plate, and the other end of the side plate is inclined away from the vertical plate.

2. The chromatography column perfusion and elution device according to claim 1, characterized in that: The mounting frame is provided with a driving component, the driving component is located below the mounting seat and connected to the mounting seat, and the driving component is used to drive the mounting seat to slide along the mounting frame.

3. The chromatography column perfusion and elution device according to claim 1, characterized in that: An elastic member is arranged between the fixing seat and the mounting seat.

4. The chromatography column perfusion and elution device according to any one of claims 1 to 3, characterized in that: The chromatography column perfusion and elution device comprises a quick connection assembly, and the fixing seat is provided with a second mounting groove matching the quick connection assembly, and the quick connection assembly is used to connect the perfusion and elution connecting component and the pipeline.

5. The chromatography column perfusion and elution device according to claim 4, characterized in that: The fixing seat is provided with a stopper, and the stopper is located above the second mounting groove.

6. The chromatography column perfusion and elution device according to claim 4, characterized in that: A partition seat is arranged on the fixing seat, and the partition seat is located below the quick connection assembly.

7. The chromatography column perfusion and elution device according to any one of claims 1 to 3, characterized in that: The color layer column installation component includes a tray, a plurality of first installation slots are arranged on the tray, and a clamping and limiting structure is arranged on the first installation slot, and the clamping and limiting structure is used to limit the color layer column so that the color layer column is installed in the first installation slot.

8. The chromatography column perfusion and elution device according to claim 7, characterized in that: The clamping and limiting structure comprises a first limiting plate and a plurality of first limiting blocks arranged on the first mounting groove, and a gap matching the color layer column is arranged between the first limiting plate and the first limiting blocks.

9. The chromatography column perfusion and elution device according to any one of claims 1 to 3, characterized in that: The perfusion and elution connecting component includes a mounting plate, a first sealing connector, a container, a second sealing connector, a connecting pipe and a quick connecting joint. The first sealing connector and the container are respectively installed on both sides of the mounting plate, the container is connected to the first sealing connector, the second sealing connector is installed on the mounting plate, the second sealing connector and the first sealing connector are located on the same side, and the connecting pipe connects the second sealing connector and the quick connecting joint.

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