Method for lipid plasma treatment of apheresis stations

Abstract

The application provides a method for processing lipid plasma in a plasma separation station, which comprises the following steps: collecting plasma by using a disposable plasma separator, heat-sealing a plasma bag after the collection is completed, connecting the plasma bag with a lipid plasma filter to filter lipid plasma, heat-sealing the plasma bag after the filtration is completed if the filtered lipid plasma still cannot meet the requirements of normal plasma, using a new lipid plasma filter to filter, and repeating the filtration until the filtered lipid plasma meets the requirements of normal plasma; a plurality of blood transfusion ports are arranged on the upper part of the plasma bag, and a lower hanging hole is arranged on the lower part of the plasma bag; the collection amount of the plasma collected by the disposable plasma separator is increased by a preset amount N compared with normal plasma. The application can effectively utilize lipid plasma, convert the lipid plasma into normal plasma, and improve the plasma collection amount of the plasma station.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of medical devices, in particular to a method for processing lipid plasma in a single plasma collection station. BACKGROUND

[0002] The statements in this section merely provide background information related to the present application and do not necessarily constitute the prior art.

[0003] A disposable centrifugal plasma separator is a device that separates human plasma by centrifugation and returns other blood cells. The separated plasma is used for the preparation of biological products. Biological product companies have requirements for raw plasma, which cannot contain a large amount of fat. Plasma containing a large amount of fat is commonly known as "lipid plasma". With the improvement of people's living standards, the intake of high-fat food has increased, and the amount of lipid plasma in a single plasma collection station has shown an upward trend.

[0004] When a plasma donor has lipid plasma, the single plasma collection station will generally stop collecting plasma, return the blood cells to the plasma donor, and discard the used consumable plasma separator product. This has several disadvantages:

[0005] 1. A set of plasma separator consumables is wasted;

[0006] 2. The plasma donor cannot donate plasma, cannot receive a plasma donation subsidy, and wastes time and transportation costs;

[0007] 3. The plasma station cannot obtain plasma, reducing the amount of plasma collected by the station. Some plasma donors can only donate plasma on weekends due to work, and if they cannot donate plasma on that day, they will delay for a week or more due to work, reducing the annual plasma collection amount of the single plasma collection station;

[0008] 4. It affects the enthusiasm of plasma donors. If a plasma donor consumes nuts or high-fat foods before donating plasma, the probability of lipid plasma increases significantly. In particular, first-time plasma donors are not aware of the precautions, and if the first-time donation is unsuccessful, it will affect the enthusiasm of subsequent donations, also affecting the number of plasma donors, and increasing the difficulty of developing plasma donors.

[0009] These unfavorable factors are not desirable for the plasma station, and currently, raw plasma is in short supply. Due to insufficient raw plasma, the production capacity of biological product companies cannot reach even half. SUMMARY

[0010] The present application proposes a method for processing lipid plasma in a single plasma collection station to solve the above problems. This method can effectively utilize lipid plasma, convert lipid plasma into ordinary plasma, and improve the plasma collection amount of the plasma station.

[0011] The application provides a lipid plasma processing method of a plasma separation station, blood plasma is collected through a disposable plasma separator, the blood plasma bag is heat sealed after collection, the blood plasma bag containing lipid plasma is connected with a lipid plasma filter to filter the lipid plasma, if the lipid plasma filtering is completed but the normal blood plasma requirement cannot be met, the lipid plasma filter after filtering is heat sealed, a new lipid plasma filter is used for filtering, and the filtering is repeated until the filtered lipid plasma meets the normal blood plasma requirement; a plurality of blood transfusion ports are arranged on the upper part of the blood plasma bag, and a lower hanging hole is arranged on the lower part of the blood plasma bag; the collection amount of the lipid plasma collected by the disposable plasma separator is increased by a preset amount N compared with the normal blood plasma.

[0012] Preferably, the lipid plasma filter comprises a first puncture device, a first flow-stopping clamp, a first three-way joint, a fat filter, a second three-way joint and a blood plasma bag which are sequentially connected through pipes, the branch output ports of the first three-way joint and the second three-way joint are connected through pipes to form an exhaust branch, the second flow-stopping clamp is arranged on the exhaust branch, a sampling branch is arranged between the second three-way joint and the blood plasma bag, and the third flow-stopping clamp is arranged on the sampling branch.

[0013] The specific filtering method of the lipid plasma filter is as follows:

[0014] S101: the upper end pipeline of the blood plasma bag containing lipid plasma is heat sealed, one side blood transfusion port is twisted open, the first puncture device of the lipid plasma filter is inserted into the blood transfusion port, and the blood plasma bag is hung up.

[0015] S102: the first flow-stopping clamp and the third flow-stopping clamp are closed, and the blood plasma bag containing lipid plasma is hung up together with the lipid plasma filter.

[0016] S103: the lipid plasma enters the lower end blood plasma bag through the fat filter, after filtering is completed, the second flow-stopping clamp is opened, the blood plasma in the blood plasma bag is squeezed to the sampling branch, and the third flow-stopping clamp is opened for sampling.

[0017] S104: the lower end blood plasma bag is heat sealed from the sampling branch, and part of the blood plasma bag is reserved.

[0018] Preferably, in the steps S101 and S102, if the blood plasma bag containing lipid plasma contains more fat, another lipid plasma filter can be inserted into another blood transfusion port of the blood plasma bag for continuous filtering.

[0019] Preferably, the sampling branch comprises a third three-way joint and a fourth three-way joint which are sequentially arranged on the pipe between the second three-way joint and the blood plasma bag, the branch output ports of the third three-way joint and the fourth three-way joint are connected with a first sampling pipe, and the third flow-stopping clamp is arranged between the third three-way joint and the first sampling pipe.

[0020] In the step S103, the plasma in the plasma bag is squeezed to the third three-way joint, the third stop clamp is opened, and the plasma in the first three-way joint and the fourth three-way joint enters the first sampling tube. In the step S104, the plasma bag is heat sealed between the second three-way joint and the third three-way joint.

[0021] Preferably, the sampling branch includes a third three-way joint arranged on a conduit between the second three-way joint and the plasma bag, and a branch output of the third three-way joint is sequentially connected with a third stop clamp, an air filter and a sampler through conduits.

[0022] In the step S103, after the filtration is completed, the first stop clamp is closed, the third stop clamp is opened, the plasma bag is squeezed so that the air in the bag is discharged through the air filter, the plasma reaches the vicinity of the air filter, the plasma sampling device is inserted into the sampler to complete the sampling, and in the step S104, the plasma bag is heat sealed between the third three-way joint and the plasma bag.

[0023] Preferably, the sampling branch includes a third three-way joint arranged on a conduit between the second three-way joint and the plasma bag, and a branch output of the third three-way joint is sequentially connected with a third stop clamp, a sampling bag and a sampler through conduits.

[0024] In the step S103, after the filtration is completed, the first stop clamp is closed, the third stop clamp is opened, the plasma bag is squeezed so that the plasma in the bag enters the sampling bag, the plasma sampling device is inserted into the sampler to complete the sampling, and in the step S104, the plasma bag is heat sealed between the third three-way joint and the plasma bag.

[0025] Preferably, the fat plasma filter includes a fifth three-way joint, a first three-way joint, a fat filter, a second three-way joint and a plasma bag which are sequentially connected through conduits, a branch output of the first three-way joint and the second three-way joint is connected through a conduit to form an exhaust branch, a second stop clamp is arranged on the exhaust branch, a sampling branch is arranged between the second three-way joint, the plasma bag and the sampling bag, two input ports of the fifth three-way joint are connected with a first puncture device and a second puncture device, a first stop clamp is arranged on a conduit between the first puncture device and the fifth three-way joint, and a fourth stop clamp is arranged on a conduit between the second puncture device and the fifth three-way joint.

[0026] The specific filtration method of the fat plasma filter is as follows:

[0027] S201: heat seal an upper conduit of a plasma bag containing fat plasma, twist off any blood transfusion port, insert the second puncture device of the fat plasma filter into the blood transfusion port, and connect the first puncture device with a 0.9% sodium chloride injection bag;

[0028] S202: close the first stop clamp, the second stop clamp and the sampling branch, and hang the plasma bag containing fat plasma together with the fat plasma filter;

[0029] S203: the fat slurry enters the lower end plasma bag through the fat filter, after the filtration is completed, the second stop clamp is opened, the plasma in the plasma bag is squeezed to the sampling branch, the sampling branch is opened for plasma sampling, after the sampling is completed, the sampling branch is closed;

[0030] S204: the fourth stop clamp and the second stop clamp are closed, the first stop clamp is opened, the 0.9% sodium chloride injection flushes the residual plasma in the pipeline and the fat filter into the plasma bag, after the plasma in the plasma bag is supplemented to the specified volume, the first stop clamp is closed;

[0031] S205: the lower end plasma bag is heat sealed from the sampling branch, and the plasma bag is reserved;

[0032] In the steps S201 and S202, if the fat content in the plasma bag filled with fat slurry is relatively high, another fat slurry filter can be inserted at another blood transfusion port of the plasma bag for continuous filtration.

[0033] Preferably, the sampling branch comprises a third three-way, a fourth three-way, a sixth three-way and a seventh three-way which are sequentially arranged on the catheter between the second three-way and the plasma bag, the branch output ports of the third three-way and the fourth three-way are connected with a first sampling tube, the branch output ports of the sixth three-way and the seventh three-way are connected with a second sampling tube, a third stop clamp is arranged on the catheter between the third three-way and the first sampling tube, and a fifth stop clamp is arranged on the catheter between the sixth three-way and the second sampling tube.

[0034] In the step S203, after the filtration is completed, the second stop clamp is opened, the plasma in the plasma bag is squeezed to the third three-way, the third stop clamp is opened, the plasma at the third three-way and the fourth three-way enters the second sampling tube, the third stop clamp is closed, the plasma in the plasma bag is squeezed to the sixth three-way, the fifth stop clamp is opened, the plasma at the sixth three-way and the seventh three-way enters the second sampling tube, and the fifth stop clamp is closed.

[0035] In the step S205, the plasma bag is heat sealed between the second three-way and the third three-way, and the plasma bag and the sampling branch are reserved.

[0036] Preferably, the sampling branch comprises a third three-way which is arranged on the catheter between the second three-way and the plasma bag, and the branch output port of the third three-way is sequentially connected with a third stop clamp, an air filter and a sampler through the catheter.

[0037] In the step S203, after the filtration is completed, the fourth stop clamp is closed, the third stop clamp is opened, the plasma bag is squeezed to make the air in the bag pass through the air filter and be discharged, the plasma reaches the vicinity of the air filter, the plasma sampling device is inserted into the sampler to complete the sampling, and in the step S204, the plasma bag is heat sealed from the third three-way and the plasma bag.

[0038] Preferably, the sampling branch includes a third three-way valve arranged on the conduit between the second three-way valve and the plasma bag, and a branch output of the third three-way valve is sequentially connected with a third pinch valve, a sampling bag and a sampler.

[0039] In the step S103, after the filtration is completed, the fourth pinch valve is closed, the third pinch valve is opened, the plasma bag is squeezed so that the plasma in the bag enters the sampling bag, the plasma sampling device is inserted into the sampler to complete the sampling, and in the step S204, the plasma bag is heat sealed from the third three-way valve and the plasma bag.

[0040] Compared with the prior art, the application has the following beneficial effects:

[0041] The method of the application adds 1-2 blood transfusion ports and a lower hanging hole to the plasma bag of the original disposable centrifugal plasma separator, and the cost is negligible, almost no additional cost, only the lipid plasma is filtered, effectively avoiding the waste of the lipid plasma filter, effectively protecting the enthusiasm of the plasma donors, facilitating the development of new plasma donors for the apheresis plasma station, increasing the collection amount of raw plasma, helping the plasma donors to reduce blood lipid indicators, being beneficial to the health of the plasma donors, and facilitating the publicity of the apheresis plasma station and the development of plasma donors. BRIEF DESCRIPTION OF DRAWINGS

[0042] The drawings accompanying the specification of the application serve to provide further understanding of the application, and the illustrative embodiments of the application and the description thereof serve to explain the application, and do not constitute an improper limitation on the application.

[0043] Figure 1 is a schematic diagram of the overall structure of the disposable plasma separator related to the application,

[0044] Figure 2 is a schematic diagram of the structure of the lipid plasma filter of the first embodiment of the application,

[0045] Figure 3 is a schematic diagram of the lipid plasma filtration implementation of the first embodiment of the application,

[0046] Figure 4 is a schematic diagram of the structure of the lipid plasma filter of the second embodiment of the application,

[0047] Figure 5 is a schematic diagram of the structure of the lipid plasma filter of the third embodiment of the application,

[0048] Figure 6 is a schematic diagram of the structure of the lipid plasma filter of the fourth embodiment of the application,

[0049] Figure 7 is a schematic diagram of the structure of the lipid plasma filter of the fifth embodiment of the application,

[0050] Figure 8This is a schematic diagram of the structure of the grease slurry filter of Example 6 of the present application.

[0051] In the picture:

[0052] 1. Venipuncture device, 2. Plasma separation cup, 3. Plasma bag, 4. Puncture device, 5. Sampling tube, 6. Pressure detection head, 7. Buffer blood bag, 8. Medical T-joint, 9. Stop clamp;

[0053] 4a, first puncture device, 4b, second puncture device, 5a, first sampling tube, 5b, second sampling, 8a, first tee, 8b, second tee, 8c, third tee, 8d, fourth tee, 8e, fifth tee, 8f, sixth tee, 8g, seventh tee, 9a, first stop-flow clamp, 9b, second stop-flow clamp, 9c, third stop-flow clamp, 9d, fourth stop-flow clamp, 9e, fifth stop-flow clamp, 10, fat filter, 11, air filter, 12, sampler, 13, sampling bag, 31, hanging hole, 32, blood transfusion port. DETAILED DESCRIPTION

[0054] The present application will be further described below with reference to the accompanying drawings and embodiments.

[0055] It should be noted that the terms used herein are only for describing specific embodiments and are not intended to limit the exemplary embodiments according to the present disclosure. As used herein, unless the context clearly indicates otherwise, the singular form is intended to include the plural form. In addition, it should be understood that when the terms "comprise" and / or "include" are used in this specification, they indicate the presence of features, steps, operations, devices, components and / or combinations thereof.

[0056] In the present disclosure, terms such as "upper", "lower", "left", "right", "front", "back", "vertical", "horizontal", "side", "bottom", etc. indicating directions or positional relationships are based on the directions or positional relationships shown in the accompanying drawings. They are merely relational words determined for the convenience of describing the structural relationships of the various parts or elements of the present disclosure, and do not specifically refer to any part or element in the present disclosure, and should not be understood as limitations on the present disclosure.

[0057] Example 1:

[0058] like Figures 1 to 5 As shown, the present application provides a method for processing lipid plasma in a single plasma collection station, wherein plasma is collected through a disposable plasma separator, and after collection is completed, the plasma bag 3 is heat-sealed and the plasma bag 3 is connected to a lipid plasma filter to filter the lipid plasma.

[0059] like Figure 1As shown, the disposable plasma separator includes a pipeline system composed of a venipuncture device 1, a buffer blood bag 7, a puncture device 4, a pressure detection head 6, a plasma separation cup 2, a plasma bag 3, a plurality of flow stop clamps 9 and a medical tee joint 8. The venipuncture device 1 draws blood from the human body, centrifugal separation is performed through the plasma separation cup 2, the plasma is stored in the plasma bag 3, and the separated blood cells are returned to the human body. The puncture device 4 is used to connect a blood anticoagulant bag, and the pressure detection head 6 is used to detect the pressure in the pipeline. The disposable plasma separator is a prior art product, and thus no further description is given herein.

[0060] If the filtered plasma still cannot meet the requirements of normal plasma, the plasma bag 3 after filtration is heat sealed, a new fat plasma filter is used for filtration, and the filtration is repeated until the filtered fat plasma meets the requirements of normal plasma.

[0061] In order to facilitate the transfer and suspension of the plasma bag containing fat plasma, a plurality of blood transfusion ports 32 are arranged on the upper part of the plasma bag 3, and a lower hanging hole 31 is formed in the lower part of the plasma bag 3. If fat plasma occurs, the amount of fat plasma collected is increased by a preset amount N compared to normal collection, so as to prevent more loss during the transfer and filtration of fat plasma. Preferably, the value of N is 10-50 ml.

[0062] The fat plasma filter disclosed in the embodiment is used for the treatment of fat plasma, and specifically, the fat plasma filter includes a first puncture device 4a, a first flow stop clamp 9a, a first tee joint 8a, a fat filter 10, a second tee joint 8b and a plasma bag 3 connected in sequence. The branch output ports of the first tee joint 8a and the second tee joint 8b are connected by a pipeline to form an exhaust branch, the second flow stop clamp 9b is arranged on the exhaust branch, a sampling branch is arranged between the second tee joint 8b and the plasma bag 3, and the third flow stop clamp 9c is arranged on the sampling branch.

[0063] The specific filtration method of the fat plasma filter is as follows:

[0064] S101: The upper end pipeline of the plasma bag 3 containing fat plasma is heat sealed, one side of the blood transfusion port 32 is twisted open, the first puncture device 4a of the fat plasma filter is inserted into the blood transfusion port 32, and the plasma bag 3 is hung up;

[0065] S102: The first flow stop clamp 9a and the third flow stop clamp 9c are closed, and the plasma bag 3 containing fat plasma is hung up together with the fat plasma filter;

[0066] S103: The fat plasma enters the lower end plasma bag 3 through the fat filter 10, after the filtration is completed, the second flow stop clamp 9b is opened, the plasma in the plasma bag 3 is squeezed to the sampling branch, and the third flow stop clamp 9c is opened for sampling; S104: The lower end plasma bag 3 is heat sealed at the sampling branch, and part of the plasma bag 3 is reserved.

[0067] The fat plasma filter of the embodiment discloses three parallel sampling branch structures:

[0068] The first kind, the sampling branch includes the third three-way 8c and the fourth three-way 8d arranged on the conduit between the second three-way 8b and the plasma bag 3 in turn, the branch output port of the third three-way 8c and the fourth three-way 8d is connected with the first sampling tube 5a, and the third stop clamp 9c is arranged between the third three-way 8c and the first sampling tube 5a;

[0069] In the step S103, the plasma in the plasma bag 3 is squeezed to the third three-way 8c, the third stop clamp 9c is opened, and the plasma at the third three-way 8c and the fourth three-way 8d enters the first sampling tube 5a, and in the step S104, the plasma bag 3 is heat sealed between the second three-way 8b and the third three-way 8c, and the plasma bag 3 and the first sampling tube 5a are reserved, and the others are treated as medical waste.

[0070] The second kind, the sampling branch includes the third three-way 8c arranged on the conduit between the second three-way 8b and the plasma bag 3, and the branch output port of the third three-way 8c is connected with the third stop clamp 9c, the air filter 11 and the sampler 12 in turn through the conduit;

[0071] In the step S103, after the filtration is completed, the first stop clamp 9a is closed, the third stop clamp 9c is opened, the plasma bag 3 is squeezed to make the air in the bag discharged through the air filter 11, the plasma reaches the vicinity of the air filter 11, the plasma sampling device is inserted into the sampler 12 to complete the sampling, and in the step S104, the plasma bag 3 is heat sealed between the third three-way 8c and the plasma bag 3, and the plasma bag 3 is frozen.

[0072] The third kind, the sampling branch includes the third three-way 8c arranged on the conduit between the second three-way 8b and the plasma bag 3, and the branch output port of the third three-way 8c is connected with the third stop clamp 9c, the sampling bag 13 and the sampler 12 in turn through the conduit;

[0073] In the step S103, after the filtration is completed, the first stop clamp 9a is closed, the third stop clamp 9c is opened, the plasma bag 3 is squeezed to make the plasma in the bag enter the sampling bag 13, the plasma sampling device is inserted into the sampler 12 to complete the sampling, and in the step S104, the plasma bag 3 is heat sealed between the third three-way 8c and the plasma bag 3.

[0074] The fat filter 10 on the fat plasma filter of the embodiment has multiple specifications, is suitable for different fat plasma conditions, the first puncture device 4a of the fat plasma filter can be inserted into the blood transfusion port 32 without falling off, the fat plasma filter has a bypass with the second stop clamp 9b, which is used for air exhaust after the subsequent plasma filtration is completed, and in the steps S101 and S102, if the fat content in the fat plasma bag 3 is relatively high, another fat plasma filter can be inserted at the other blood transfusion port 32 of the fat plasma bag 3 to continue the filtration.

[0075] Embodiment two:

[0076] As shown in Figure 1 , Figures 6 to 8 , the application provides a lipid plasma treatment method for apheresis station. Plasma is collected by a disposable plasma separator. After the collection is completed, the plasma bag 3 is heat sealed. The plasma bag 3 is connected with the lipid plasma filter to filter the lipid plasma.

[0077] As shown in Figure 1 , the disposable plasma separator includes a pipeline system composed of a venous puncture device 1, a buffer blood bag 7, a puncture device 4, a pressure detection head 6, a plasma separation cup 2, a plasma bag 3, a plurality of flow stop clamps 9, and a medical tee joint 8. The venous puncture device 1 takes blood from the human body, centrifugal separation is performed through the plasma separation cup 2, the plasma is stored in the plasma bag 3, and the separated blood cells are returned to the human body. The puncture device 4 is used to connect a blood anticoagulant bag. The pressure detection head 6 is used to detect the pressure in the pipeline. The disposable plasma separator is a product, and the application will not be described in detail.

[0078] If the filtered lipid plasma still cannot meet the requirements of normal plasma, the plasma bag 3 after filtration is heat sealed, a new lipid plasma filter is used for filtration, and the filtration is repeated until the filtered lipid plasma meets the requirements of normal plasma.

[0079] In order to facilitate the transfer and suspension of the plasma bag containing lipid plasma, a plurality of blood transfusion ports 32 are arranged on the upper part of the plasma bag 3, and a lower hanging hole 31 is arranged on the lower part of the plasma bag 3. If lipid plasma occurs, the lipid plasma collection amount is increased by a preset amount N than normal collection, so as to prevent more loss during the transfer and filtration of lipid plasma. Preferably, the value of N is 10-50 ml.

[0080] The embodiment discloses a lipid plasma filter for processing lipid plasma. Specifically, the lipid plasma filter includes a fifth tee joint 8e, a first tee joint 8a, a fat filter 10, a second tee joint 8b, and a plasma bag 3 connected in sequence. The branch output ports of the first tee joint 8a and the second tee joint 8b are connected by a conduit to form an exhaust branch. A second flow stop clamp 9b is arranged on the exhaust branch. A sampling branch is arranged between the second tee joint 8b, the plasma bag 3, and a sampling bag. Two input ports of the fifth tee joint 8e are connected with a first puncture device 4a and a second puncture device 4b. A first flow stop clamp 9a is arranged on the conduit between the first puncture device 4a and the fifth tee joint 8e. A fourth flow stop clamp 9d is arranged on the conduit between the second puncture device 4b and the fifth tee joint 8e.

[0081] The specific filtration method of the lipid plasma filter is as follows:

[0082] S201: heat seal the upper end pipeline of the plasma bag 3 containing lipid slurry, unscrew any blood transfusion port 32, insert the second puncture device 4b of the lipid slurry filter into the blood transfusion port 32, and connect the first puncture device 4a with the 0.9% sodium chloride injection bag;

[0083] S202: close the first flow stop clamp 9a, the second flow stop clamp 9b, and the sampling branch, and hang the plasma bag 3 containing lipid slurry together with the lipid slurry filter;

[0084] S203: the lipid slurry passes through the fat filter 10 into the lower end plasma bag 3, after the filtration is completed, open the second flow stop clamp 9b, squeeze the plasma in the plasma bag 3 to the sampling branch, open the sampling branch for plasma sampling, after the sampling is completed, close the sampling branch;

[0085] S204: close the fourth flow stop clamp 9d and the second flow stop clamp 9b, open the first flow stop clamp 9a, the 0.9% sodium chloride injection flushes the residual plasma in the pipeline and the fat filter 10 into the plasma bag 3, after the plasma in the plasma bag 3 is supplemented to the specified volume, close the first flow stop clamp 9a;

[0086] S205: heat seal the lower end plasma bag 3 from the sampling branch, and retain the plasma bag 3.

[0087] The lipid slurry filter of the embodiment discloses three parallel sampling branches:

[0088] The first sampling branch comprises a third three-way joint 8c, a fourth three-way joint 8d, a sixth three-way joint 8f, and a seventh three-way joint 8g arranged on the pipeline between the second three-way joint 8b and the plasma bag 3 in sequence, the branch output ports of the third three-way joint 8c and the fourth three-way joint 8d are connected with a first sampling tube 5a, the branch output ports of the sixth three-way joint 8f and the seventh three-way joint 8g are connected with a second sampling tube 5b, a third flow stop clamp 9c is arranged on the pipeline between the third three-way joint 8c and the first sampling tube 5a, and a fifth flow stop clamp 9e is arranged on the pipeline between the sixth three-way joint 8f and the second sampling tube 5b;

[0089] In the step S203, after the filtration is completed, open the second flow stop clamp 9b, squeeze the plasma in the plasma bag 3 to the third three-way joint 8c, open the third flow stop clamp 9c, the plasma at the third three-way joint 8c and the fourth three-way joint 8d enters the second sampling tube 5a, close the third flow stop clamp 9c, squeeze the plasma in the plasma bag 3 to the sixth three-way joint 8f, open the fifth flow stop clamp 9e, the plasma at the sixth three-way joint 8f and the seventh three-way joint 8g enters the second sampling tube 5b, and close the fifth flow stop clamp 9e;

[0090] In the step S205, heat seal the plasma bag 3 from the second three-way joint 8b and the third three-way joint 8c, and retain the plasma bag 3 and the sampling branch, so as to facilitate subsequent detection.

[0091] The second kind of sampling branch includes a third three-way valve 8c arranged on the conduit between the second three-way valve 8b and the plasma bag 3, and the branch output of the third three-way valve 8c is sequentially connected with a third stop clamp 9c, an air filter 11 and a sampler 12 through conduits.

[0092] In the step S203, after the filtration, the fourth stop clamp 9d is closed, the third stop clamp 9c is opened, the plasma bag 3 is squeezed to make the air in the bag discharged through the air filter 11, the plasma reaches the vicinity of the air filter 11, the plasma sampling device is inserted into the sampler 12 to complete the sampling, and in the step S204, the plasma bag 3 is heat sealed from the third three-way valve 8c and the plasma bag 3.

[0093] The third kind of sampling branch includes a third three-way valve 8c arranged on the conduit between the second three-way valve 8b and the plasma bag 3, and the branch output of the third three-way valve 8c is sequentially connected with a third stop clamp 9c, a sampling bag 13 and a sampler 12 through conduits.

[0094] In the step S103, after the filtration, the fourth stop clamp 9d is closed, the third stop clamp 9c is opened, the plasma bag 3 is squeezed to make the plasma in the bag enter the sampling bag 13, the plasma sampling device is inserted into the sampler 12 to complete the sampling, and in the step S204, the plasma bag 3 is heat sealed from the third three-way valve 8c and the plasma bag 3.

[0095] In the steps S201 and S202, if the fat content in the plasma bag 3 containing fat plasma is relatively high, another fat plasma filter can be inserted at the other transfusion port 32 of the plasma bag 3 to continue the filtration.

[0096] The fat filter of the fat plasma filter has multiple specifications, which are suitable for different fat plasma conditions. The fat plasma filter has two puncture devices 4. The second puncture device 4b is connected with the plasma bag containing fat plasma, and the first puncture device 4a can be connected with 0.9% sodium chloride injection, which is used for flushing the plasma in the pipeline or / and supplementing the plasma to a specified volume. The puncture device 4 of the fat plasma filter can be inserted into the transfusion port 32 without falling off. The fat plasma filter has a bypass with a stop clamp, which is used for air discharge after the subsequent plasma filtration is completed.

[0097] The application increases several transfusion ports 32 and hanging holes 31 on the original plasma bag 3 of the disposable centrifugal plasma separator, which has negligible cost and almost no additional cost. Only the fat plasma is filtered, which effectively avoids the waste of the fat plasma filter, effectively protects the enthusiasm of the plasma donors, facilitates the development of new plasma donors in the single plasma collection station, increases the collection amount of raw plasma, helps the plasma donors to reduce blood lipid indicators, is beneficial to the health of the plasma donors, and facilitates the publicity of the single plasma collection station and the development of plasma donors.

[0098] The above are merely preferred embodiments of the present application and are not intended to limit the present application. Those skilled in the art will readily appreciate that various modifications and variations are possible. Any modifications, equivalent substitutions, or improvements made within the spirit and principles of the present application shall be included within the scope of protection of the present application.

[0099] Although the above describes the specific implementation methods of the present application in conjunction with the accompanying drawings, it does not limit the scope of protection of the present application. Technical personnel in the relevant field should understand that on the basis of the technical solution of the present application, various modifications or variations that can be made by technical personnel in this field without creative work are still within the scope of protection of the present application.

Claims

1. A method for processing lipid plasma at a plasmapheresis station, characterized by: The plasma is collected by a disposable plasma separator, and after the collection is completed, the plasma bag (3) containing the lipid plasma is heat-sealed and separated, and the plasma bag (3) is connected to a lipid plasma filter to filter the lipid plasma; If the lipid plasma still cannot reach the normal plasma requirement after filtration, heat-seal the plasma bag (3) of the lipid plasma filter after filtration, and then use a new lipid plasma filter connected to the plasma bag (3) for filtration, and repeat the filtration until the filtered lipid plasma reaches the normal plasma requirement; The upper portion of the plasma bag (3) is provided with a plurality of blood transfusion sockets (32), and the lower portion of the plasma bag (3) is provided with a lower hanging hole (31); The amount of lipid plasma collected by the disposable plasma separator is increased by a preset amount N compared to normal plasma; The fat plasma filter comprises a first puncture device (4a), a first stop clamp (9a), a first tee (8a), a fat filter (10), a second tee (8b), and a plasma bag (3) which are sequentially connected by conduits. The branch output ports of the first tee (8a) and the second tee (8b) are connected by conduits to form an exhaust branch. A second stop clamp (9b) is provided on the exhaust branch. A sampling branch is provided between the second tee (8b) and the plasma bag (3). A third stop clamp (9c) is provided on the sampling branch. The specific filtering method of the grease slurry filter is: S101: The plasma bag containing lipid slurry (3) is heat-sealed on the upper end of the line, unscrew one side of the blood transfusion socket (32), the first puncture device (4a) of the lipid slurry filter is inserted into the blood transfusion socket (32), and the plasma bag is hung (3); S102: Close the first stopper clip (9a) of the lipid slurry filter, the third stopper clip (9c), the plasma bag (3) containing lipid slurry is hung together with the lipid slurry filter; S103: The fat slurry passes through the fat filter (10) and enters the lower plasma bag (3). After the filtration is completed, the second stop clamp (9b) is opened to squeeze the plasma in the lower plasma bag (3) to the sampling branch, and the third stop clamp (9c) is opened to take samples; S104: Heat-seal the lower end plasma bag (3) from the sampling branch, and retain the plasma bag (3); In the steps S101 and S102, if the fat content in the plasma bag (3) containing lipid plasma is relatively high, another lipid plasma filter can be plugged into another blood transfusion port (32) of the plasma bag (3) and filtered.

2. The method for processing lipid plasma at a single plasma collection station according to claim 1, characterized in that: The sampling branch comprises a third tee (8c) and a fourth tee (8d) sequentially arranged on the catheter between the second tee (8b) and the plasma bag (3); the branch output ports of the third tee (8c) and the fourth tee (8d) are connected to the first sampling tube (5a); and a third flow-stop clamp (9c) is arranged between the third tee (8c) and the first sampling tube (5a); In step S103, the plasma in the plasma bag (3) is squeezed to the third tee (8c), the third stop clamp (9c) is opened, and the plasma at the third tee (8c) and the fourth tee (8d) enters the first sampling tube (5a). In step S104, the plasma bag (3) is heat-sealed between the second tee (8b) and the third tee (8c).

3. The method for processing lipid plasma at a plasmapheresis station according to claim 1, characterized in that: The sampling branch comprises a third tee (8c) provided on a conduit between the second tee (8b) and the plasma bag (3), wherein the branch outlet of the third tee (8c) is connected to a third flow-stopping clamp (9c), an air filter (11), and a sampler (12) in sequence through the conduit; In the step S103, after the filtration is completed, the first stop clamp (9a) is closed, the third stop clamp (9c) is opened, and the plasma bag (3) is squeezed to discharge the air in the bag through the air filter (11). The plasma reaches the vicinity of the air filter (11), and the plasma sampling device is inserted into the sampler (12) to complete the sampling. In the step S104, the plasma bag (3) is heat-sealed between the third three-way valve (8c) and the plasma bag (3).

4. The method for processing lipid plasma at a plasmapheresis station according to claim 1, characterized in that: The sampling branch comprises a third tee (8c) provided on a conduit between the second tee (8b) and the plasma bag (3); the branch outlet of the third tee (8c) is connected to a third flow-stop clamp (9c), a sampling bag (13), and a sampler (12) in sequence through the conduit; In step S103, after the filtration is completed, the first stop clamp (9a) is closed, the third stop clamp (9c) is opened, the plasma bag (3) is squeezed to allow the plasma in the bag to enter the sampling bag (13), and the plasma sampling device is inserted into the sampler (12) to complete the sampling. In step S104, the plasma bag (3) is heat-sealed between the third three-way pipe (8c) and the plasma bag (3).

5. A method for processing lipid plasma at a plasmapheresis station, characterized by: The plasma is collected by a disposable plasma separator, and after the collection is completed, the plasma bag (3) containing the lipid plasma is heat-sealed and separated, and the plasma bag (3) is connected to a lipid plasma filter to filter the lipid plasma; If the lipid plasma still cannot reach the normal plasma requirement after filtration, heat-seal the plasma bag (3) of the lipid plasma filter after filtration, and then use a new lipid plasma filter connected to the plasma bag (3) for filtration, and repeat the filtration until the filtered lipid plasma reaches the normal plasma requirement; The upper portion of the plasma bag (3) is provided with a plurality of blood transfusion sockets (32), and the lower portion of the plasma bag (3) is provided with a lower hanging hole (31); The amount of lipid plasma collected by the disposable plasma separator is increased by a preset amount N compared to normal plasma; The lipid-slurry filter comprises a fifth tee (8e), a first tee (8a), a fat filter (10), a second tee (8b), and a plasma bag (3) which are connected in sequence by conduits. The branch output ports of the first tee (8a) and the second tee (8b) are connected by conduits to form an exhaust branch. A second flow-stopping clamp (9b) is provided on the exhaust branch. A sampling branch is provided between the second tee (8b), the plasma bag (3), and the sampling bag. The two input ports of the fifth tee (8e) are connected to a first puncture device (4a) and a second puncture device (4b). A first flow-stopping clamp (9a) is provided on the conduit between the first puncture device (4a) and the fifth tee (8e), and a fourth flow-stopping clamp (9d) is provided on the conduit between the second puncture device (4b) and the fifth tee (8e). The specific filtering method of the grease slurry filter is: S201: Heat-seal the upper end of the plasma bag (3) containing lipid plasma, unscrew any blood transfusion socket (32), insert the second puncture device (4b) of the lipid plasma filter into the blood transfusion socket (32), and connect the first puncture device (4a) to the 0.9% sodium chloride injection bag; S202; close the first stop clamp (9a), the second stop clamp (9b), the sampling branch, and hang the plasma bag (3) containing the lipid slurry together with the lipid slurry filter; S203: The fat slurry passes through the fat filter (10) and enters the lower plasma bag (3). After the filtration is completed, the second stop clamp (9b) is opened to squeeze the plasma in the lower plasma bag (3) to the sampling branch. The sampling branch is opened to sample the plasma. After the sampling is completed, the sampling branch is closed. S204: Close the fourth stop clamp (9d) and the second stop clamp (9b), open the first stop clamp (9a), and flush the plasma remaining in the pipeline and the fat filter (10) into the plasma bag (3) with 0.9% sodium chloride injection. After the plasma in the plasma bag (3) is replenished to the specified volume, close the first stop clamp (9a); S205: Heat-seal the lower end plasma bag (3) from the sampling branch, and retain the plasma bag (3); In the steps S201 and S202, if the fat content in the plasma bag (3) containing lipid plasma is relatively high, another lipid plasma filter can be plugged into another blood transfusion port (32) of the plasma bag (3) to continue filtering.

6. The method for processing lipid plasma at a plasmapheresis station according to claim 5, characterized in that: The sampling branch comprises a third tee (8c), a fourth tee (8d), a sixth tee (8f), and a seventh tee (8g) which are sequentially arranged on the conduit between the second tee (8b) and the plasma bag (3); the branch output ports of the third tee (8c) and the fourth tee (8d) are connected to the first sampling tube (5a); the branch output ports of the sixth tee (8f) and the seventh tee (8g) are connected to the second sampling tube (5b); a third stop-flow clamp (9c) is arranged on the conduit between the third tee (8c) and the first sampling tube (5a); and a fifth stop-flow clamp (9e) is arranged on the conduit between the sixth tee (8f) and the second sampling tube (5b); In step S203, after the filtration is completed, the second stop clamp (9b) is opened, the plasma in the plasma bag (3) is squeezed to the third tee (8c), the third stop clamp (9c) is opened, the plasma at the third tee (8c) and the fourth tee (8d) enters the first sampling tube (5a), the third stop clamp (9c) is closed, the plasma in the plasma bag (3) is squeezed to the sixth tee (8f), the fifth stop clamp (9e) is opened, the plasma at the sixth tee (8f) and the seventh tee (8g) enters the second sampling tube (5b), and the fifth stop clamp (9e) is closed; In step S205, the plasma bag (3) is heat-sealed between the second tee (8b) and the third tee (8c), retaining the plasma bag (3) and the sampling branch.

7. The method for processing lipid plasma at a plasmapheresis station according to claim 5, characterized in that: The sampling branch comprises a third tee (8c) provided on a conduit between the second tee (8b) and the plasma bag (3), wherein the branch outlet of the third tee (8c) is connected to a third flow-stopping clamp (9c), an air filter (11), and a sampler (12) in sequence through the conduit; In step S203, after the filtration is completed, the fourth stop clamp (9d) is closed, the third stop clamp (9c) is opened, and the plasma bag (3) is squeezed to discharge the air in the bag through the air filter (11). The plasma reaches the vicinity of the air filter (11), and the plasma sampling device is inserted into the sampler (12) to complete the sampling. In step S204, the plasma bag (3) is heat-sealed between the third three-way valve (8c) and the plasma bag (3).

8. The method for processing lipid plasma at a plasmapheresis station according to claim 5, characterized in that: The sampling branch comprises a third tee (8c) provided on a conduit between the second tee (8b) and the plasma bag (3); the branch outlet of the third tee (8c) is connected to a third flow-stop clamp (9c), a sampling bag (13), and a sampler (12) in sequence through the conduit; In step S203, after the filtration is completed, the fourth stop clamp (9d) is closed, the third stop clamp (9c) is opened, the plasma bag (3) is squeezed to allow the plasma in the bag to enter the sampling bag (13), and the plasma sampling device is inserted into the sampler (12) to complete the sampling. In step S204, the plasma bag (3) is heat-sealed between the third three-way valve (8c) and the plasma bag (3).

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