Preparation method of color weakness correction glasses with adjustable absorption band

Abstract

The present application belongs to the technical field of optical material preparation, and relates to a preparation method of color weakness correction glasses with adjustable absorption band, wherein the correction lens comprises a base lens and a metal nano-composite material doped in the base lens, the composite material is composed of gold nanoparticles capable of producing surface plasmon resonance effect and a material capable of keeping the stability of the properties, and the composite material can be combined with the base lens and play an effect. Through processing of a large amount of patient disease information, a machine learning platform for obtaining three-dimensional information of gold nanoparticle size, half-height width and concentration according to patient RGB information is deployed, on the basis of which, the preparation of a narrow-band gold nano-composite material is carried out, and corresponding particles are added according to the disease degree of the patient; meanwhile, the disease degrees of different patients are also different, and the particles can be mixed in different proportions, so that the effect of adjustable absorption band can be achieved, accurate color filtering can be achieved, and the effect of customization for different patients can be achieved.

Description

TECHNICAL FIELD

[0001] The application relates to a preparation method of color weakness correction glasses with adjustable absorption bands. BACKGROUND

[0002] Color vision deficiency (CVD), commonly known as color blindness, is a hereditary eye disease that limits the ability of patients to distinguish certain colors. At present, there is no corresponding treatment method for treatment, and only some auxiliary means can be used for correction. Although the traditional super surface glasses and dye glasses can enable the patients to see specific colors, the patients lose the color perception of other colors (such as blue), and the glasses obtained by the method cannot be customized according to the patient's own condition.

[0003] At present, there is no effective treatment method for color blindness, so in order to improve the phenomenon of color blindness, color blindness glasses are needed. The existing color weakness correction glasses are mainly prepared by coating and adding pigments, which can enable the patients to identify the numbers in the color weakness detection diagram that cannot be clearly seen by blocking specific waveband light. However, this method will cause some deviation of the patients to short-wave light (such as blue light), so that the patients will have a large deviation in seeing other colors except red and green, and the colors seen by the patients cannot be consistent with those seen by ordinary people. At the same time, the waveband blocked by the added pigment is fixed, and cannot be customized according to the patient's own condition, and due to the potential carcinogenicity of the pigment, it is difficult to apply in the field of contact type glasses such as contact lenses. SUMMARY

[0004] The application provides a preparation method of color weakness correction glasses with adjustable absorption bands. Through processing of a large amount of patient disease information, a machine learning platform is deployed, which can inversely deduce three-dimensional information of gold nanoparticle size, half-height width and concentration according to patient RGB information. On this basis, a narrow-band gold nano-composite material is prepared, and corresponding particles are added according to the patient's disease degree. At the same time, the disease degrees of different patients are different (reflected in the offset and half-height width), and the particles can be mixed in different proportions to achieve the effect of adjustable absorption bands, so that accurate color filtering can be achieved, and the glasses can be customized for different patients.

[0005] To achieve the above-mentioned purposes, the technical scheme of the application is as follows:

[0006] A preparation method of color weakness correction glasses with adjustable absorption bands comprises the following steps:

[0007] Step one: collection and processing of patient information, convert the collected RGB information of the patient into corresponding spectral information, classify and process the spectral information according to the difference of patient spectrum;

[0008] Step two: training and deployment of machine learning:

[0009] Compare the processed spectral information in step one with the required particles, establish the relationship between the three-channel input value of the patient's RGB three-channel color model and the three-dimensional output information containing the size, half-width and concentration of gold nanoparticles, and form a data set;

[0010] Pass the data set to the training platform built, and get the best model after a large number of training;

[0011] Use the best model for testing, and deploy it in the corresponding network after successful testing. The deployed machine learning network aims to establish the relationship between the patient's disease information and the required gold nano composite material.

[0012] Step three: preparation of gold nano composite material:

[0013] The RGB information of the patient in step one is processed by the machine learning program deployed in step two to obtain three-dimensional information containing the size, half-width and concentration of gold nanoparticles for the patient, so as to customize the colorblindness and weak color vision correction glasses.

[0014] 0.6mL of 0.01M sodium borohydride solution prepared with ice water is added to 10mL of 0.1M cetyltrimethylammonium bromide and 0.25mL of 10mM chloroauric acid, and stirred at 1200rpm for 1min to obtain a seed solution. Add an appropriate amount of freshly prepared seed solution to the growth solution, and obtain gold nanoparticles after 24h. After centrifugal washing, disperse in 1.5mM cetyltrimethylammonium bromide for standby;

[0015] Add tetraethyl orthosilicate and sodium hydroxide to coat the gold nanoparticles with a thin layer of silicon dioxide. After 48h of reaction, wash with water and ethanol, and then disperse in an equal amount of ethanol; The mass fraction of TEOS is 20%, and it is added dropwise every 1h, a total of three times, which can make the coated silicon dioxide shell more uniform,

[0016] Add octadecyltrimethoxysilane chloroform solution and ammonia water, and centrifuge with ethanol for two times after 48h, and disperse in an equal amount of toluene;

[0017] Step four: synthesis of PMMA lens:

[0018] The gold nanocomposite prepared in step three is mixed with the precursor solution of the base lens, the mixed solution is stirred and then ultrasonicated to make the particles uniformly dispersed, and then the mixed solution is poured into the mold for preparing the lens;

[0019] The mold is placed in a vacuum drying oven and dried in a vacuum environment for 1h, and then heated and cured to obtain the color weak color blindness correction glasses.

[0020] The mass fraction of tetraethyl orthosilicate in step three is 20%, and is added dropwise every 1h for a total of three times, and the PH value is adjusted to 10-11 using 25% ammonia water with a mass fraction, which can make the coated silica shell more uniform.

[0021] The stirring speed in step four is 2000rpm, the stirring time is 2min, and the heating and curing temperature is 70℃.

[0022] The gold nanoparticles in the gold nanocomposite in step four that can produce surface plasmon resonance effect are gold nanospheres and gold nanocubes.

[0023] The precursor solution of the base lens in step four is methyl methacrylate, MBS, dibutyl phthalate, acrylate, methacrylic acid, epoxy soybean oil, dibenzoyl peroxide, dioctyl phthalate, polystyrene, chlorinated polyethylene, stearic acid, methyl styrene oligomer, paraffin, organic tin stabilizer, and toluene diisocyanate dissolved in toluene.

[0024] The collected RGB information of the patient in step one is converted into corresponding spectral information by formula (1)

[0025] Y=0.2126R+0.7152G+0.0722B

[0026] Where Y is the color matching curve, R is the value collected by the red sensor, G is the value collected by the green sensor, and B is the value collected by the blue sensor.

[0027] The classified spectral information in step one includes the spectral shift and half-width information of the patient, and the spectral shift is the amount of red shift or blue shift.

[0028] Therefore, the application establishes the connection between the patient's disease and the three-dimensional information of the added nanoparticle size, half-width and concentration by processing a large number of collected patient disease information and through machine learning, so that the most suitable glasses for each different patient can be customized. In addition, the size and half-width of the required particles are different for each patient with different degrees of illness, so the gold nanocomposite with narrow-band absorption is synthesized, the doping ratio of particles of different sizes is calculated by using FDTD and Origin software according to the required particle conditions of the patient, so as to achieve the purpose of adjustable absorption band. After calculating the three-dimensional information of the particle size, half-width and concentration required by the patient, the corresponding particles are synthesized, and the silica shell coating and ligand exchange are carried out. Then, the synthesized gold nanocomposite is mixed with the precursor of the base lens, and after stirring, drying and solidification, the customized corrective glasses for the patient are obtained.

[0029] The application synthesizes and prepares a color blindness and weak color vision glasses with adjustable absorption band, and the absorption band can be adjusted between 530-590nm according to the degree of illness of the patient, so as to better fit the patient and maximize the patient's color perception to normal people.

[0030] Compared with the prior art, the application has the beneficial effects that:

[0031] The application synthesizes gold nanoparticles with good monodispersity, obtains the narrow-band absorption characteristic, and for patients who need wide-band absorption characteristics, the doping ratio of various particles required can be calculated by using FDTD and Origin software simulation, so as to further fit different patient groups.

[0032] After training and deploying machine learning, the customization method of the lens can be changed from professional medical workers to simple and easy to understand like the configuration of myopia glasses in an optical store. After the gold nanoparticles are coated with silica and the ligand exchange is carried out, not only the stability of the material is enhanced, but also the composite material can be better combined with the base lens material to solidify into a lens. The preparation method is simple, the cost is low, the stability is good, the selected material has high biocompatibility, and can be used not only for the synthesis of ordinary lenses, but also for the field of contact lenses. Compared with the traditional method of using dye, the color blindness and weak color vision corrective glasses can dope gold nanocomposites of different sizes, half-widths and concentrations according to the patient's illness to customize glasses for the patient. BRIEF DESCRIPTION OF DRAWINGS

[0033] In order to more clearly illustrate the technical solutions in the embodiments of the present application or the prior art, the accompanying drawings needed to be used in the embodiments or prior art description will be briefly introduced as follows. Obviously, the accompanying drawings in the following description only represent some embodiments of the present application, and for those skilled in the art, other drawings can also be obtained from these accompanying drawings without any creative effort.

[0034] Figure 1 A flowchart of a preparation method of a color weakness correction glasses with adjustable absorption band according to Embodiment 1 of the present application;

[0035] Figure 2 A normalized FDTD simulation diagram of gold nanoparticles of different sizes according to the present application at 530-590nm;

[0036] Figure 3 A normalized extinction spectrum diagram of gold nanoparticles of different sizes synthesized according to the present application;

[0037] Figure 4 A transmission electron microscope (TEM) diagram of gold nanoparticles synthesized according to the present application;

[0038] Figure 5 An extinction spectrum diagram of gold nanoparticles after adjusting the absorption band according to the present application;

[0039] Figure 6 A transmission electron microscope (TEM) diagram of gold nanocomposites synthesized according to the present application. DETAILED DESCRIPTION

[0040] The specific embodiments of the present application will be further described in conjunction with the accompanying drawings. It is to be noted that the descriptions of these embodiments are used to help understand the present application, but do not constitute a limitation on the present application. In addition, the technical features involved in the various embodiments of the present application described below can be combined with each other as long as they do not conflict with each other.

[0041] Embodiment 1:

[0042] Gold nanospheres and gold nanocubes are synthesized by seed growth method. 0.6 mL of 0.01 M sodium borohydride solution prepared by freshly configuring ice water is added to 10 mL of 0.1 M hexadecyltrimethylammonium bromide and 0.25 mL of 10 mM chloroauric acid mixed solution, and the seed solution is obtained by stirring at a speed of 1200 rpm for 1 min. 400 μL of the freshly prepared seed solution is added to the growth solution, and the synthesized gold nanoparticles are washed twice under the condition of centrifugation at 7000 rpm for 20 min, and then stored in 1.5 M hexadecyltrimethylammonium bromide (CTAB) solution for standby.

[0043] Take out 5 mL of the prepared gold nanoparticle solution, add 50 μL of 0.1 M sodium hydroxide (NaOH) solution, then add 15 μL of tetraethyl orthosilicate (TEOS) (20% volume fraction) ethanol solution every 1 h, a total of three times, grow for two days, then clean with water and ethanol at 7000 rpm, and finally disperse in 2 mL of ethanol to obtain a gold nanocomposite solution.

[0044] Dropwise add 800 μL of octadecyltrimethoxysilane (OTMS) chloroform solution (2.4% mass fraction) to 2 mL of gold nanocomposite solution (containing 80 μL of NH4OH (32%)); after 24 h of reaction, centrifuge at 7000 rpm, wash twice with ethanol, and obtain a gold nanocomposite solution that can be dispersed in non-polar solvents after ligand exchange, and finally disperse in 2 mL of toluene.

[0045] Dissolve methyl methacrylate, MBS (methyl methacrylate, butadiene, and styrene terpolymer), dibutyl phthalate, acrylate (ACR), methacrylic acid, epoxy soybean oil, dibenzoyl peroxide, DOP (dioctyl phthalate), polystyrene, chlorinated polyethylene (CPE), stearic acid, oligomer of methylstyrene (AMS), paraffin, organotin stabilizer, toluene diisocyanate, and gold nanorod composite dissolved in toluene in a ratio of 10:2:2:1:0.5:5:0.1:10:1:10:1:5:1:5:2.5:10, take out 2 mL of the solution and put it into a mold, and after vacuum drying and heating and curing of the material, PMMA lenses can be obtained.

[0046] Reference Figure 1 The preparation method flowchart of the color weakness correction glasses with adjustable absorption bands according to the embodiment 1 of the present application is shown in the figure. The information of the patient is collected and converted into corresponding spectral information, and the spectral information is used as a data set for machine learning and analysis of the required particle reference of the patient. Finally, the particles are made into corresponding lenses to assist in the correction of the patient. After a large amount of data set training, the machine learning can be deployed, thereby achieving the effect of auxiliary diagnosis.

[0047] Embodiment 2

[0048] The difference between this embodiment and embodiment 1 is that the amount of seeds added for synthesizing gold nanoparticles is different, so that the size of the finally grown gold nanoparticles is different.

[0049] The gold nanospheres and gold nanocubes were synthesized by seed growth method. 0.6 mL of 0.01 M sodium borohydride solution prepared by ice water was added to 10 mL of 0.1 M hexadecyl trimethyl ammonium bromide and 0.25 mL of 10 mM chloroauric acid mixed solution, and the seed solution was obtained by stirring at 1200 rpm for 1 min. When the seed was added, 400 μL, 200 μL, 100 μL, 50 μL, 20 μL and 10 μL of seed solution were added respectively to obtain gold nanoparticles of different sizes. The synthesized gold nanoparticles were washed twice under the condition of centrifugation at 7000 rpm for 20 min and stored in 1.5 mM CTAB solution for standby.

[0050] 5 mL of the previously prepared gold nanoparticle solution was taken out, 50 μL of 0.1 M NaOH solution was added, and then 15 μL of TEOS (20% by volume) ethanol solution was added every 1 h for a total of three times. After growing for two days, the gold nanocomposite solution was obtained by washing with water and ethanol once respectively at 7000 rpm and finally dispersing in 2 mL of ethanol.

[0051] 800 μL of OTMS chloroform solution (2.4%) (mass fraction) was added dropwise to 2 mL of gold nanocomposite solution (containing 80 μL of NH4OH (32%)); after reaction for 24 h, the gold nanocomposite solution which could be dispersed in non-polar solvents after ligand exchange was obtained by centrifugal separation at 7000 rpm and washing with ethanol twice, and finally dispersing in 2 mL of toluene.

[0052] Methyl methacrylate, MBS, dibutyl phthalate, acrylate (ACR), methacrylic acid, epoxy soybean oil, dibenzoyl peroxide, DOP (dioctyl phthalate), polystyrene, chlorinated polyethylene (CPE), stearic acid, oligomer of methyl styrene (AMS), paraffin, organotin stabilizer, toluene-2, 5-diformyl, and gold nanorod composite dissolved in toluene were mixed in a ratio of 10:2:2:1:0.5:5:0.1:10:1:10:1:5:1:5:2.5:10, and then dissolved in toluene. 2 mL of the solution was taken out and put into a mold. After vacuum drying and heating curing of the material, PMMA lenses were obtained.

[0053] Referring to Figure 2 The normalized FDTD simulation diagram of gold nanoparticles of different sizes prepared in Example 2 of the present application shows that the gold nanoparticles can be made to absorb at 530-590 nm by changing the size of the gold nanoparticles. Referring to Figure 3Normalized extinction spectra of gold nanoparticles of different sizes prepared in Example 2 of the present application, the absorption range of the spectra of the particles is 525-580 nm, so as long as the gold nanoparticles of appropriate size are synthesized, the absorption range required by the patient can be completely covered. See Figure 4 TEM micrograph of gold nanoparticles of different sizes prepared in Example 2 of the present application, the gold nanoparticles in the micrograph are gold nanocubes, and the average size is 40 nm.

[0054] Example 3

[0055] The difference between this example and Example 1 is that mixing of gold nanoparticles is performed to achieve tunable absorption bands.

[0056] Gold nanospheres and gold nanocubes are synthesized by seed growth method, 0.6 mL of 0.01 M sodium borohydride solution prepared with ice water is added to 10 mL of 0.1 M hexadecyl trimethyl ammonium bromide and 0.25 mL of 10 mM chloroauric acid mixed solution, and the seed solution is obtained by stirring at 1200 rpm for 1 min. When the seed is added, 400 μL, 200 μL, 100 μL, 50 μL, 20 μL and 10 μL of seed solution are added respectively, so as to obtain gold nanoparticles of different sizes. The six sizes of gold nanoparticles are numbered a-f in order of size from small to large, and after mixing according to the ratio of 1:1:5:1:1, they are placed in an ultrasonic instrument for ultrasonic treatment for 2 min. After washing twice under the condition of centrifugation at 7000 rpm for 20 min, they are stored in 1.5 mM CTAB solution for standby.

[0057] 5 mL of the previously prepared gold nanoparticle solution is taken out, 50 μL of 0.1 M NaOH solution is added, and then 15 μL of TEOS (20% by volume) ethanol solution is added every 1 h, a total of three times. After growing for two days, they are washed with water and ethanol once respectively at 7000 rpm, and finally dispersed in 2 mL of ethanol to obtain a gold nanoparticle composite solution.

[0058] 800 μL of OTMS chloroform solution (2.4%) (mass fraction) is added dropwise to 2 mL of gold nanoparticle composite solution (containing 80 μL of NH4OH (32%)); after reaction for 24 h, centrifugal separation is performed at 7000 rpm, and washing is performed twice with ethanol to obtain a gold nanoparticle composite solution which can be dispersed in a non-polar solvent after ligand exchange, and finally dispersed in 2 mL of toluene.

[0059] Methyl methacrylate, MBS, dibutyl phthalate, acrylate (ACR), methacrylic acid, epoxy soybean oil, dibenzoyl peroxide, DOP, (dioctyl phthalate), polystyrene, chlorinated polyethylene (CPE), stearic acid, oligomer of methyl styrene (AMS), paraffin, organic tin stabilizer, toluene, toluene, and gold nanorod composite dissolved in toluene were mixed in a ratio of 10:2:2:1:0.5:5:0.1:10:1:10:1:5:1:5:2.5:10, and then dissolved in toluene. 2 mL of the solution was taken out and put into a mold. After vacuum drying and heating and curing of the material, a PMMA lens was obtained.

[0060] Referring to Figure 5 The extinction spectrum of the gold nanoparticles with adjusted absorption bands obtained by mixing the gold nanoparticles of different sizes prepared in Example 3 in a ratio is shown in the figure. It can be seen that after mixing in the calculated ratio, the absorption band of the gold nanoparticles is red-shifted from 533 nm to 543 nm, and the half-height width is increased from 57 nm to 83 nm. Therefore, according to the different adjustment ratios, the peak position and half-height width of the absorption band of the synthesized gold nanoparticles are different.

[0061] Example 4

[0062] The difference between this example and Example 1 is that the amount of TEOS added is different, so the thickness of the silica shell coated is different.

[0063] Gold nanospheres and gold nanocubes were synthesized by seed growth method. 0.6 mL of 0.01 M sodium borohydride solution prepared with ice water was added to 10 mL of 0.1 M cetyltrimethylammonium bromide and 0.25 mL of 10 mM chloroauric acid mixed solution, and stirred at 1200 rpm for 1 min to obtain a seed solution. 400 μL of the freshly prepared seed solution was added to the growth solution, and the synthesized gold nanoparticles were washed twice under the condition of centrifugation at 7000 rpm for 20 min and stored in 1.5 mM CTAB solution for standby.

[0064] Five 20 mL sample bottles were taken out, 5 mL of the previously prepared gold nanoparticle solution was added to each, 50 μL of 0.1 M NaOH solution was added, and then 5 μL, 10 μL, 15 μL, 20 μL, and 25 μL of TEOS (20% volume fraction) ethanol solution was added to each bottle every 1 h, a total of three times. After growing for two days, they were washed with water and ethanol once at 7000 rpm, and finally dispersed in 2 mL of ethanol to obtain a gold nanocomposite solution.

[0065] Dropwise add 800 μL OTMS chloroform solution (2.4%) (mass fraction) to 2 mL gold nanocomposite solution (containing 80 μL NH4OH (32%)); after reaction for 24 h, centrifugal separation at 7000 rpm, and washing twice with ethanol, obtain the gold nanocomposite solution after ligand exchange which can be dispersed in non-polar solvents, and finally dispersed in 2 mL toluene.

[0066] Dissolve methyl methacrylate, MBS, dibutyl phthalate, acrylic ester (ACR), methacrylic acid, epoxy soybean oil, dibenzoyl peroxide, DOP (dioctyl phthalate), polystyrene, chlorinated polyethylene (CPE), stearic acid, oligomer of methyl styrene (AMS), paraffin, organic tin stabilizer, toluene isocyanate, and gold nanorod composite dissolved in toluene in a ratio of 10:2:2:1:0.5:5:0.1:10:1:10:1:5:1:5:2.5:10, take out 2 mL solution and put into a mold, and after vacuum drying, heating and curing of the material, PMMA lens can be obtained.

[0067] Referring to Figure 6 The TEM image of gold nanometer particles coated with a silica shell layer prepared in Example 4 of the present application is shown in the figure, wherein the gold nanoparticles are gold nanospheres, the diameter of the gold nanospheres is 96.3 nm, and the thickness of the silica shell layer is 20.5 nm. The gold nanoparticles can be kept stable in nature by coating the silica shell layer, and preparation work for dissolving into non-polar solvents to synthesize lenses is done.

[0068] The embodiments of the present application are described in detail above with reference to the accompanying drawings, but the present application is not limited to the described embodiments. For those skilled in the art, various changes, modifications, replacements and variations of the embodiments can be made without departing from the principles and spirits of the present application, and still fall within the protection scope of the present application.

Claims

1. A method for preparing colorblindness correction glasses with adjustable absorption band, characterized in that: Includes the following steps: Step 1: Collection and processing of patient information. The collected RGB information of the patient is converted into corresponding spectral information, and the spectral information is classified and processed according to the different patient spectra. Step Two: Training and Deployment of Machine Learning: The spectral information processed in step one is compared with the required particles to establish the relationship between the three-channel input values ​​of the patient's RGB three-channel color model and the three-dimensional output information containing the size, half-width, and concentration of gold nanoparticles, thus forming a dataset. The dataset is transferred to the training platform that has been built, and the best model is obtained after extensive training. Use the best model for testing, and deploy it to the appropriate network after successful testing; Step 3: Preparation of gold nanocomposite materials: The prepared seed solution was added to the growth solution, and gold nanoparticles were obtained after 24 hours. After centrifugation and washing, they were dispersed in 1.5 mM hexadecyltrimethylammonium bromide for later use. By adding tetraethyl orthosilicate and sodium hydroxide, gold nanoparticles are coated with a thin layer of silica. After reacting for 48 hours, they are washed with water and ethanol, and then dispersed in an equal amount of ethanol. Add octadecyltrimethoxysilane chloroform solution and ammonia water. After 48 hours, wash twice with ethanol by centrifugation and disperse in an equal volume of toluene. Step 4: Assembly of PMMA lenses: The gold nanocomposite material prepared in step three is mixed with the precursor solution of the substrate lens. The mixed solution is stirred and then sonicated to disperse the particles evenly. The mixed solution is then poured into the mold for preparing the lens. The mold was placed in a vacuum drying oven and dried in a vacuum environment for 1 hour, and then heated and cured to obtain color-blindness correction glasses.

2. The method for preparing colorblindness correction glasses with adjustable absorption band according to claim 1, characterized in that: In step three, the mass fraction of tetraethyl orthosilicate is 20%, and it is added dropwise once every 1 hour for a total of three times. The pH value is adjusted to 10-11 using 25% ammonia water.

3. The method for preparing colorblindness correction glasses with adjustable absorption band according to claim 1, characterized in that: In step four, the stirring speed is 2000 rpm, the stirring time is 2 min, and the heating and curing temperature is 70℃.

4. The method for preparing colorblindness correction glasses with adjustable absorption band according to claim 1, characterized in that: In step four, the gold nanoparticles in the gold nanocomposite material that can generate surface plasmon resonance effects are gold nanospheres and gold nanocubes.

5. The method for preparing a colorblindness correction eyeglass with adjustable absorption band according to claim 1, characterized in that: In step four, the precursor solution for the base lens is composed of methyl methacrylate, MBS, dibutyl phthalate, acrylates, methacrylic acid, epoxidized soybean oil, benzoyl peroxide, dioctyl phthalate, polystyrene, chlorinated polyethylene, stearic acid, oligomers of methylstyrene, paraffin wax, organotin stabilizer, and toluene diisocyanate dissolved in toluene.

6. The method for preparing a colorblindness correction eyeglass with adjustable absorption band according to claim 1, characterized in that: The RGB information of the patient in step one is processed by the machine learning program deployed in step two to obtain three-dimensional information for the patient, including the size, half-width, and concentration of gold nanoparticles. Then, in step three, the color blindness and color weakness correction glasses are customized.

7. The method for preparing colorblindness correction glasses with adjustable absorption band according to claim 1, characterized in that: In step one, the collected RGB information of the patient is converted into corresponding spectral information using formula (1). Y = 0.2126R + 0.7152G + 0.0722B Where Y is the color matching curve, R is the value collected by the red sensor, G is the value collected by the green sensor, and B is the value collected by the blue sensor.

8. The method for preparing a colorblindness correction eyeglass with adjustable absorption band according to claim 1, characterized in that: The spectral information classified and processed in step one includes the patient's spectral shift and full width at half maximum (FWHM) information. The spectral shift is the amount of red shift or blue shift.

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