Magnetic resonance imaging method, vascular imaging method, device, equipment and medium

Abstract

The present application relates to a magnetic resonance imaging method, a vascular imaging method, an apparatus, a computer device and a storage medium. The magnetic resonance imaging method comprises: applying a first imaging sequence to obtain a first group of magnetic resonance signals of at least two layers, the first imaging sequence comprises a simultaneous imaging sequence and a marking pulse whose application position is between at least two layers; applying a second imaging sequence to obtain a second group of magnetic resonance signals of at least two layers, the second imaging sequence comprises a simultaneous imaging sequence, and no marking pulse is applied between the at least two layers; acquiring an arterial vascular image and a venous vascular image based on the first group of magnetic resonance signals and the second group of magnetic resonance signals. The present method can simultaneously image arteries and veins in a single shot.

Description

Technical Field

[0001] The present application relates to the field of magnetic resonance imaging technology, and in particular to a magnetic resonance imaging method, a vascular imaging method, an apparatus, a computer device and a storage medium. Background Art

[0002] With the development of intelligent medical technology, magnetic resonance angiography (MRA) technology has emerged. It has the characteristics of simple operation, non-invasiveness, and no need for contrast agents, and has become one of the conventional methods for vascular examination. In magnetic resonance angiography, there is a type of arterial spin labeling angiography technology, which uses a fast imaging sequence combined with a magnetization preparation pulse to suppress arteries or veins, and then silhouettes to achieve arterial or venous imaging.

[0003] However, the current arterial spin labeling vascular imaging technology can only realize arterial imaging or venous imaging at a time. When arteriovenous images are needed, at least two imagings are required, which makes the operation complicated. Summary of the invention

[0004] Based on this, it is necessary to provide a magnetic resonance imaging method, a vascular imaging method, a device, an equipment and a medium that can simultaneously image arteries and veins in a single shot in order to solve the above-mentioned technical problems.

[0005] A magnetic resonance imaging method, comprising:

[0006] Applying a first imaging sequence to acquire a first set of magnetic resonance signals of at least two slices, the first imaging sequence comprising a simultaneous imaging sequence and a marking pulse applied at a position between the at least two slices;

[0007] Applying a second imaging sequence to acquire a second set of magnetic resonance signals of at least two slices, wherein the second imaging sequence comprises a simultaneous imaging sequence and no labeling pulse is applied between the at least two slices;

[0008] An arterial blood vessel image and a venous blood vessel image are acquired according to the first group of magnetic resonance signals and the second group of magnetic resonance signals.

[0009] In one embodiment, application of the marking pulse makes the arterial magnetic resonance signal at one level have lower intensity than that at another level; or makes the venous magnetic resonance signal at one level have higher intensity than that at another level.

[0010] In one embodiment, the parameters of the marking pulse are determined by blood flow rate and inversion time.

[0011] In one embodiment, the number of slices on both sides of the marking pulse is the same or different.

[0012] A vascular imaging method, comprising:

[0013] Acquire first magnetic resonance images of at least two layers by using a simultaneous imaging sequence, wherein the first magnetic resonance image of one layer has arterial blood pixels and venous blood pixels with different signal intensities relative to the first magnetic resonance image of another layer;

[0014] Acquire second magnetic resonance images of the at least two layers by using a simultaneous imaging sequence, wherein the second magnetic resonance image of one layer has arterial blood pixels and venous blood pixels with the same signal intensity relative to the second magnetic resonance image of another layer;

[0015] Performing differential processing on the first magnetic resonance image and the second magnetic resonance image to acquire a blood vessel image.

[0016] In one embodiment, the first magnetic resonance image or the second magnetic resonance image is generated by:

[0017] Simultaneously exciting magnetic resonance signals of at least two levels;

[0018] Acquiring magnetic resonance signals containing inter-layer aliasing;

[0019] Acquire a reference image of a single slice excitation;

[0020] The magnetic resonance signal is anti-aliased by using the reference image as a reference to obtain the first magnetic resonance image or the second magnetic resonance image.

[0021] In one embodiment, performing differential processing on the first magnetic resonance image and the second magnetic resonance image to obtain a blood vessel image includes:

[0022] The first magnetic resonance image and the second magnetic resonance image obtained by imaging at the same layer are differentially processed to obtain an arterial blood vessel image and a venous blood vessel image respectively.

[0023] A magnetic resonance imaging device, comprising:

[0024] A first group of magnetic resonance signal acquisition modules, for applying a first imaging sequence to acquire a first group of magnetic resonance signals of at least two layers, wherein the first imaging sequence comprises a simultaneous imaging sequence and a marking pulse whose application position is between the at least two layers;

[0025] a second group of magnetic resonance signal acquisition modules, configured to apply a second imaging sequence to acquire a second group of magnetic resonance signals of at least two slices, wherein the second imaging sequence comprises a simultaneous imaging sequence, and no marking pulse is applied between the at least two slices;

[0026] The image generation module is used to acquire an arterial blood vessel image and a venous blood vessel image according to the first group of magnetic resonance signals and the second group of magnetic resonance signals.

[0027] A vascular imaging device, comprising:

[0028] A first magnetic resonance image acquisition module, configured to acquire first magnetic resonance images of at least two layers by using a simultaneous imaging sequence, wherein the first magnetic resonance image of one layer has arterial blood pixels and venous blood pixels with different signal intensities relative to the first magnetic resonance image of another layer;

[0029] A second magnetic resonance image acquisition module is used to acquire second magnetic resonance images of the at least two layers by using a simultaneous imaging sequence, wherein the second magnetic resonance image of one layer has arterial blood pixels and venous blood pixels with the same signal intensity as the second magnetic resonance image of another layer;

[0030] The blood vessel image acquisition module is used to perform differential processing on the first magnetic resonance image and the second magnetic resonance image to acquire a blood vessel image.

[0031] A computer device comprises a memory and a processor, wherein the memory stores a computer program, and the processor implements the steps of the method described in any one of the above embodiments when executing the computer program.

[0032] A computer-readable storage medium stores a computer program, which, when executed by a processor, implements the steps of the method described in any one of the above embodiments.

[0033] The magnetic resonance imaging method, vascular imaging method, device, equipment and medium described above respectively apply a first imaging sequence and a second imaging sequence according to the opposite directions of blood flow between arteries and veins, thereby acquiring a first group of magnetic resonance signals and a second group of magnetic resonance signals of at least two layers. The first imaging sequence includes a simultaneous imaging sequence and a marker pulse whose application position is between at least two layers, while the second imaging sequence does not apply a marker pulse between at least two layers, so that arterial vascular imaging and venous vascular imaging can be obtained according to the first group of magnetic resonance signals and the second group of magnetic resonance signals, and simultaneous imaging of arteries and veins is achieved without increasing the scanning time. BRIEF DESCRIPTION OF THE DRAWINGS

[0034] Figure 1 A diagram showing an application environment of a magnetic resonance imaging method and a vascular imaging method in an embodiment;

[0035] Figure 2 is a schematic flow chart of a magnetic resonance imaging method in one embodiment;

[0036] Figure 3 is a schematic diagram of a gradient echo sequence in one embodiment;

[0037] Figure 4 is a schematic diagram of a balanced steady-state free precession sequence in one embodiment;

[0038] Figure 5 is an application diagram of a magnetic resonance imaging method in an embodiment;

[0039] Figure 6 is a schematic diagram of a marking pulse in one embodiment;

[0040] Figure 7 is a schematic diagram of the reversal time in one embodiment;

[0041] Figure 8 is a schematic diagram of the TI-SCOUT technology in one embodiment;

[0042] Fig. 9 is a schematic flow chart of a blood vessel imaging method in one embodiment;

[0043] Fig.10 is a structural block diagram of a magnetic resonance imaging device in one embodiment;

[0044] Fig.11 is a structural block diagram of a vascular imaging device in one embodiment;

[0045] Fig.12 FIG. 4 is a diagram showing the internal structure of a computer device in one embodiment. DETAILED DESCRIPTION

[0046] In order to make the purpose, technical solution and advantages of the present application more clearly understood, the present application is further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present application and are not used to limit the present application.

[0047] The magnetic resonance imaging method and vascular imaging method provided in this application can be applied to Figure 1In the application environment shown. The terminal 102 communicates with the medical imaging device 104 through a network. The terminal 102 sends a first imaging sequence and a second imaging sequence to the medical imaging device 104, so that the medical imaging device 104 applies the first imaging sequence to the object to be tested to obtain a first group of magnetic resonance signals of at least two layers, the first imaging sequence includes a simultaneous imaging sequence and a marker pulse whose application position is between at least two layers, and the medical imaging device 104 applies the second imaging sequence to the object to be tested to obtain a second group of magnetic resonance signals of at least two layers, the second imaging sequence includes a simultaneous imaging sequence, and no marker pulse is applied between at least two layers. In this way, the terminal obtains arterial vascular images and venous vascular images according to the first group of magnetic resonance signals and the second group of magnetic resonance signals obtained by the medical imaging device 104 applying the above-mentioned first imaging sequence and second imaging sequence.

[0048] Among them, the terminal 102 can be, but is not limited to, various personal computers, laptops, smart phones, tablet computers, portable wearable devices, and functional modules and dedicated circuits of the medical imaging device itself. In this embodiment, the terminal 102 may include a patient's mobile terminal device and / or a medical operator's mobile terminal device. The medical imaging device 104 includes, but is not limited to, various imaging devices, such as CT imaging devices (CT: Computed Tomography, which uses a precisely collimated X-ray beam and a highly sensitive detector to perform a section scan one after another around a certain part of the human body, and through CT scanning, an accurate three-dimensional position image of a tumor, etc. can be reconstructed), magnetic resonance equipment (which is a type of tomography, which uses the magnetic resonance phenomenon to obtain electromagnetic signals from the human body and reconstruct a human body information image), positron emission computed tomography (Positron Emission Computed Tomography) equipment, positron emission magnetic resonance imaging system (PET / MR), etc.

[0049] In one embodiment, Figure 2 As shown, a magnetic resonance imaging method is provided, which is applied to Figure 1 The terminal in is used as an example to illustrate, including the following steps:

[0050] S202: Apply a first imaging sequence to obtain a first group of magnetic resonance signals of at least two slices, the first imaging sequence comprising a simultaneous imaging sequence and a marking pulse applied at a position between the at least two slices.

[0051] Specifically, the first imaging sequence includes a simultaneous imaging sequence and a marking pulse whose application position is between at least two layers. The marking pulse can mark the liquid (such as blood, cerebrospinal fluid, etc.) flowing into the detection area, and image the liquid during the period of flowing into the inspection area. The marking pulse can be a region selective inversion pulse or a self-selected marking pulse. The simultaneous imaging sequence can be a gradient echo (GRE) sequence or a balanced steady-state free precession (GRE_bSSFP) sequence, which can be specifically referred to in Figure 3 and Figure 4 As shown. The simultaneous imaging sequence of different layers uses a radio frequency pulse, which excites multiple layers simultaneously. The radio frequency pulse can be multi-band, for example, a multi-band radio frequency pulse is used to achieve the purpose of simultaneously exciting different layers. Figure 3 and Figure 4 In the figure, RF is the applied multi-band radio frequency pulse, GS is the slice selection gradient pulse, GP is the applied phase encoding gradient, which needs to be applied repeatedly 128 times, and the amplitude changes linearly, GR is the frequency encoding gradient, and signal is the final gradient echo or balanced steady-state free precession gradient echo.

[0052] The labeling pulse or spin labeling pulse is applied between at least two layers. In one embodiment, the labeling pulse is a region selective inversion pulse, wherein the region selective inversion pulse includes a 180-degree inversion pulse, a 90-degree excitation pulse and a 180-degree rephase pulse. In the scanning, a 180-degree RF pulse is first given, which reverses the magnetization vector M from the positive Z axis to the negative Z axis, and then the magnetization vector is restored along the positive Z axis. The 90-degree RF pulse turns the magnetization vector slice to the XY plane, and then a 180-degree rephase pulse is applied to generate an echo signal within the TE time. The inversion time TI of the region selective inversion pulse is the interval between the initial RF pulse (for example, the 180° inversion pre-pulse in the figure) and the 90-degree RF pulse; TE is the effective echo time, which in this embodiment is the interval between the midpoint of the 90-degree RF pulse and the midpoint of the echo; TR is the time interval between two adjacent executions of the pulse sequence. In the inversion recovery sequence or the rapid inversion recovery sequence containing the labeling pulse, TR refers to the time interval between the midpoints of two adjacent 180-degree inversion pre-pulses.

[0053] S204: Apply a second imaging sequence to obtain a second set of magnetic resonance signals of at least two slices, the second imaging sequence includes a simultaneous imaging sequence, and no marking pulse is applied between the at least two slices.

[0054] Specifically, the second imaging sequence includes a simultaneous imaging sequence, and no labeling pulse is applied between at least two slices.

[0055] The simultaneous imaging sequence can be a gradient echo (GRE) sequence or a balanced steady-state free precession (GRE_bSSFP) sequence. For details, see Figure 3 and Figure 4 As shown. The simultaneous imaging sequence of different layers uses a radio frequency pulse, which excites multiple layers simultaneously. The radio frequency pulse can be multi-band, for example, a multi-band radio frequency pulse is used to achieve the purpose of simultaneously exciting different layers. Figure 3 and Figure 4 In the figure, RF is the applied multi-band radio frequency pulse, GS is the slice selection gradient pulse, GP is the applied phase encoding gradient, which needs to be applied repeatedly 128 times, and the amplitude changes linearly, GR is the frequency encoding gradient, and signal is the final gradient echo or balanced steady-state free precession gradient echo.

[0056] S206: Acquire an arterial blood vessel image and a venous blood vessel image according to the first group of magnetic resonance signals and the second group of magnetic resonance signals.

[0057] Specifically, see Figure 5 As shown, Figure 5 FIG. 1 is an application diagram of a magnetic resonance imaging method in an embodiment, wherein a first imaging sequence is applied, namely Figure 5 On the left side of the image, since the flow directions of the artery and vein are opposite, the first arterial bright blood image and the first venous black blood image are obtained at the second imaging level, and the first arterial black blood image and the first venous bright blood image are obtained at the first imaging level. That is, the first group of magnetic resonance signals includes: the first arterial bright blood image, the first venous black blood image, the first arterial black blood image and the first venous bright blood image. Applying the second imaging sequence, that is Figure 5 On the right side of the figure, since no regional selective inversion pulse is applied, both the images obtained at the second imaging level and the first imaging level are bright blood images. Assuming that the first imaging level is the second arterial bright blood image and the second venous bright blood image, and the second imaging level is the third arterial bright blood image and the third venous bright blood image, the second group of magnetic resonance signals includes the second arterial bright blood image, the second venous bright blood image, the third arterial bright blood image and the third venous bright blood image.

[0058] The arterial blood vessel image and the venous blood vessel image can be obtained by calculating according to the above-mentioned first group of magnetic resonance signals and the second group of magnetic resonance signals. For example, the corresponding arterial blood vessel image and the venous blood vessel image can be obtained according to the difference of the images obtained successively at the same imaging level. For example, at the first imaging level, the first obtained image is the first arterial black blood image and the first venous bright blood image, and the second obtained image is the second arterial bright blood image and the second venous bright blood image. The arterial blood vessel image can be obtained by subtracting the two. At the second imaging level, the first obtained image is the first arterial bright blood image and the first venous black blood image, and the second obtained image is the third arterial bright blood image and the third venous bright blood image. The venous blood vessel image can be obtained by subtracting the two.

[0059] The magnetic resonance imaging method described above applies the first imaging sequence and the second imaging sequence respectively according to the opposite directions of blood flow between arteries and veins, thereby acquiring the first group of magnetic resonance signals and the second group of magnetic resonance signals of at least two layers. The first imaging sequence includes a simultaneous imaging sequence and a marker pulse whose application position is between at least two layers, while the second imaging sequence does not apply a marker pulse between at least two layers, so that arterial vascular imaging and venous vascular imaging can be obtained according to the first group of magnetic resonance signals and the second group of magnetic resonance signals, and simultaneous imaging of arteries and veins is achieved without increasing the scanning time.

[0060] In one embodiment, application of the marking pulse makes the arterial magnetic resonance signal at one level have a lower intensity than that at another level; or makes the venous magnetic resonance signal at one level have a higher intensity than that at another level.

[0061] Specifically, combined Figure 6 As shown, Figure 6 FIG. 1 is a schematic diagram of a marking pulse in an embodiment. In this embodiment, the marking pulse is set as a region selective inversion pulse. When the TI time elapses, that is, when a 90-degree pulse is applied, the magnetization vector of the tissue in the negative Z axis is restored to 0, so the signal of the tissue in the image is completely suppressed. Figure 5 As shown, what is collected at the second imaging level is the first arterial bright blood image. After the region selective inversion pulse processing, the arterial bright blood signal is restored to 0 at the first imaging level, so what is collected is the first arterial black blood image. Similarly, for the first venous black blood image collected at the second level, after the region selective inversion pulse processing, the venous black blood signal is amplified at the first imaging level, so what is collected is the first venous bright blood image.

[0062] In one embodiment, the location at which the marking pulse is applied is determined by blood flow rate and reversal time.

[0063] Specifically, the application position, direction, thickness and other characteristics of the regional inversion pulse can be determined by the blood flow rate and the inversion time, or a positioning interface can be provided and determined by the user through manual selection.

[0064] Specifically, the application position of the regional selective inversion pulse is determined by optimizing the TI time and blood flow rate. Magnetic resonance imaging technology (MRI) has been increasingly widely used in clinical diagnosis and scientific research, and has the advantages of safety, multiple contrasts, and good resolution of soft tissues. In non-enhanced vascular imaging, there is a type of arterial vascular imaging technology that uses a fast imaging sequence to first apply a regional selective inversion pulse (IR) preparation pulse, suppress the signal within the regional selective inversion pulse IR layer, and wait for the TI time to perform fast imaging sequence acquisition. Due to the influx of blood outside the regional selective inversion pulse IR layer, the influx of blood is not affected by the regional selective inversion pulse IR, and the desired vascular signal is obtained at the imaging level, while the background signal is suppressed by IR. For details, please refer to Figure 7 As shown in FIG, before vascular imaging, the TI-SCOUT technology in delayed cardiac enhancement imaging is used to collect images with different TI values, thereby selecting the optimal TI value. The TI-SCOUT technology used can be found in Figure 8 shown.

[0065] In one embodiment, the number of slices on either side of the marking pulse is the same or different.

[0066] The two sides of the marking pulse may each include one layer; or one side may include one layer and the other side may include multiple layers.

[0067] The example of one side being one layer and the other side being multiple layers is used for illustration. Figure 5 As shown, it is assumed that the side where the first imaging layer is located also includes another third imaging layer, and the side where the second imaging layer is located only includes the second imaging layer. In this way, the first imaging sequence is applied, that is, Figure 5 On the left side of the image, since the flow directions of the artery and vein are opposite, the first arterial bright blood image and the first venous black blood image are obtained at the second imaging level, the first arterial black blood image and the first venous bright blood image are obtained at the first imaging level, and the fourth arterial black blood image and the fourth venous bright blood image are obtained at the third imaging level. That is, the first group of magnetic resonance signals includes: the first arterial bright blood image, the first venous black blood image, the first arterial black blood image, and the first venous bright blood image.

[0068] Apply a second imaging sequence, namely Figure 5On the right side of the figure, since no labeling pulse is applied, the images obtained at the first imaging level, the first imaging level, and the third imaging level are all bright blood images. It is assumed that the first imaging level is the second arterial bright blood image and the second venous bright blood image, the second imaging level is the third arterial bright blood image and the third venous bright blood image, and the third imaging level is the fourth arterial bright blood image and the fourth venous bright blood image. Therefore, the second group of magnetic resonance signals includes the second arterial bright blood image, the second venous bright blood image, the third arterial bright blood image, the third venous bright blood image, the fourth arterial bright blood image, and the fourth venous bright blood image.

[0069] Thus, the venous image and arterial image can be obtained by making a difference between the images obtained twice at the first imaging level and the second imaging level, and the venous image and arterial image can also be obtained by making a difference between the images obtained twice at the third imaging level and the second imaging level, but the positions of the venous image and arterial image obtained are different. Therefore, the venous image and arterial image of a larger range can be obtained based on the venous images and arterial images at different positions, thereby improving the imaging speed.

[0070] In the above embodiment, when the other side is multi-layered, the multi-layers are excited simultaneously, which can improve the imaging speed.

[0071] In one embodiment, Fig. 9 As shown, a vascular imaging method is provided, which is applied to Figure 1 The terminal in is used as an example to illustrate, including the following steps:

[0072] S902: Acquire first magnetic resonance images of at least two layers using a simultaneous imaging sequence, wherein the first magnetic resonance image of one layer has arterial blood pixels and venous blood pixels with different signal intensities relative to the first magnetic resonance image of another layer.

[0073] Specifically, combined Figure 5 As shown, according to the opposite directions of arterial and venous blood flow, a multi-layer simultaneous imaging technique is used to simultaneously acquire signals of at least two layers, one layer below the regional selective inversion pulse layer, and one layer above the regional selective inversion pulse layer. In this way, the first magnetic resonance image of one layer has arterial blood pixels and venous blood pixels with different signal intensities relative to the first magnetic resonance image of another layer through the regional selective inversion pulse layer.

[0074] S904: Acquire second magnetic resonance images of at least two layers using a simultaneous imaging sequence, wherein the second magnetic resonance image of one layer has arterial blood pixels and venous blood pixels with the same signal intensity as the second magnetic resonance image of another layer.

[0075] Specifically, combined Figure 5 As shown, Figure 5 On the right side in FIG. 1 , since the region selective inversion pulse as the labeling pulse is not applied, the second magnetic resonance image of one slice has arterial blood pixels and venous blood pixels with the same signal intensity as the second magnetic resonance image of another slice.

[0076] S906: Perform differential processing on the first magnetic resonance image and the second magnetic resonance image to obtain a blood vessel image.

[0077] Specifically, combined Figure 5 By performing differential processing on the magnetic resonance images obtained at the same level, a vascular image can be obtained.

[0078] Optionally, performing differential processing on the first magnetic resonance image and the second magnetic resonance image to obtain a vascular image includes: performing differential processing on the first magnetic resonance image and the second magnetic resonance image obtained by imaging at the same level to obtain an arterial vascular image and a venous vascular image, respectively.

[0079] Specifically, combined Figure 5 , Figure 5 On the left side of the image, since the flow directions of the artery and vein are opposite and the marking pulse layer is applied, the first arterial bright blood image and the first venous black blood image are obtained at the second imaging level, and the first arterial black blood image and the first venous bright blood image are obtained at the first imaging level. That is, the first group of magnetic resonance signals includes: the first arterial bright blood image, the first venous black blood image, the first arterial black blood image and the first venous bright blood image. Figure 5 On the right side of the figure, since no marking pulse layer is applied, what is obtained at the second imaging level and the first imaging level are bright blood images. Assuming that the first level is the second arterial bright blood image and the second venous bright blood image, and the second level is the third arterial bright blood image and the third venous bright blood image, the second group of magnetic resonance signals includes the second arterial bright blood image, the second venous bright blood image, the third arterial bright blood image and the third venous bright blood image.

[0080] Thus, at the first imaging level, the first obtained image is the first arterial black blood image and the first venous bright blood image, and the second obtained image is the second arterial bright blood image and the second venous bright blood image. By subtracting the two, an arterial blood vessel image can be obtained. At the second imaging level, the first obtained image is the first arterial bright blood image and the first venous black blood image, and the second obtained image is the third arterial bright blood image and the third venous bright blood image. By subtracting the two, a venous blood vessel image can be obtained.

[0081] The above-mentioned vascular imaging method, according to the opposite directions of blood flow in arteries and veins, performs two simultaneous imagings, wherein the first magnetic resonance image of one layer in the first imaging has arterial blood pixels and venous blood pixels with different signal intensities relative to the first magnetic resonance image of another layer, and the second magnetic resonance image of one layer in the second imaging has arterial blood pixels and venous blood pixels with the same signal intensities relative to the second magnetic resonance image of another layer, so that arterial vascular imaging and venous vascular imaging can be obtained based on the first magnetic resonance image and the second magnetic resonance image, and simultaneous imaging of arteries and veins is achieved without increasing the scanning time. In one embodiment, the generation method of the first magnetic resonance image or the second magnetic resonance image includes: simultaneously exciting magnetic resonance signals of at least two layers; collecting magnetic resonance signals containing inter-layer aliasing; obtaining a reference image excited by a single layer; and using the reference image as a reference to perform anti-aliasing on the magnetic resonance signal to obtain the first magnetic resonance image or the second magnetic resonance image.

[0082] Specifically, using a simultaneous imaging sequence to acquire a first magnetic resonance image of at least two levels may include: simultaneously exciting magnetic resonance signals of at least two slices; optionally, the terminal may adopt a method of modulating RF phase to achieve relative movement (controlled aliasing) between multiple slice images; acquiring magnetic resonance signals containing inter-layer aliasing; acquiring a reference image of a single-layer excitation, wherein the contrast and resolution of the reference image of the single-layer excitation may be different from those of a vascular imaging image; and using the single-layer image as a reference to perform anti-aliasing on an image corresponding to the acquired magnetic resonance signal, wherein the anti-aliasing calculation method includes but is not limited to slice-GRAPPA.

[0083] Acquiring a second magnetic resonance image of at least two layers using a simultaneous imaging sequence, including: simultaneously exciting magnetic resonance signals of at least two slices; optionally, the terminal can adopt a method of modulating RF phase to achieve relative movement (controlled aliasing) between multiple slice images; acquiring magnetic resonance signals containing inter-layer aliasing; acquiring a reference image of a single-layer excitation; or multiplexing a reference image corresponding to the first magnetic resonance image group and using the acquired single-layer image as a reference to perform anti-aliasing on an image corresponding to the acquired magnetic resonance signal, wherein the anti-aliasing calculation method includes but is not limited to slice-GRAPPA.

[0084] It should be understood that although Figure 2 and Fig. 9 The steps in the flowchart are shown in sequence as indicated by the arrows, but these steps are not necessarily executed in the order indicated by the arrows. Unless otherwise specified in this document, there is no strict order restriction for the execution of these steps, and these steps can be executed in other orders. Moreover, Figure 2 and Fig. 9At least part of the steps may include multiple steps or multiple stages. These steps or stages are not necessarily performed at the same time, but can be performed at different times. The execution order of these steps or stages is not necessarily sequential, but can be performed in turn or alternately with other steps or at least part of the steps or stages in other steps.

[0085] In one embodiment, Fig.10 As shown, a magnetic resonance imaging device is provided, comprising: a first group of magnetic resonance signal acquisition modules 1002, a second group of magnetic resonance signal acquisition modules 1004 and an image generation module 1006, wherein:

[0086] A first group of magnetic resonance signal acquisition module 1002 is used to apply a first imaging sequence to acquire a first group of magnetic resonance signals of at least two layers, wherein the first imaging sequence includes a simultaneous imaging sequence and a marking pulse applied at a position between at least two layers;

[0087] A second group of magnetic resonance signal acquisition module 1004 is used to apply a second imaging sequence to acquire a second group of magnetic resonance signals of at least two slices, wherein the second imaging sequence includes a simultaneous imaging sequence, and no marking pulse is applied between at least two slices;

[0088] The image generation module 1006 is used to acquire an arterial blood vessel image and a venous blood vessel image according to the first group of magnetic resonance signals and the second group of magnetic resonance signals.

[0089] In one embodiment, application of the marking pulse makes the arterial magnetic resonance signal at one level have a lower intensity than that at another level; or makes the venous magnetic resonance signal at one level have a higher intensity than that at another level.

[0090] In one embodiment, the parameters of the marking pulse are determined by the blood flow rate and the inversion time.

[0091] In one embodiment, the number of slices on either side of the marking pulse is the same or different.

[0092] In one embodiment, Fig.11 As shown, a vascular imaging device is provided, comprising: a first magnetic resonance image acquisition module 1102, a second magnetic resonance image acquisition module 1104 and a vascular image acquisition module 1106, wherein:

[0093] A first magnetic resonance image acquisition module 1102 is configured to acquire first magnetic resonance images of at least two layers by using a simultaneous imaging sequence, wherein the first magnetic resonance image of one layer has arterial blood pixels and venous blood pixels with different signal intensities relative to the first magnetic resonance image of another layer;

[0094] A second magnetic resonance image acquisition module 1104 is configured to acquire second magnetic resonance images of at least two layers by using a simultaneous imaging sequence, wherein the second magnetic resonance image of one layer has arterial blood pixels and venous blood pixels with the same signal intensity as the second magnetic resonance image of another layer;

[0095] The blood vessel image acquisition module 1106 is used to perform differential processing on the first magnetic resonance image and the second magnetic resonance image to acquire a blood vessel image.

[0096] In one embodiment, the vascular imaging device may further include:

[0097] The excitation module is used to simultaneously excite magnetic resonance signals of at least two layers.

[0098] The first signal acquisition module is used to acquire magnetic resonance signals containing inter-layer aliasing.

[0099] The reference image acquisition module is used to acquire a reference image for excitation of a single layer.

[0100] The anti-aliasing module is used to perform anti-aliasing on the magnetic resonance signal by taking the reference image as a reference to obtain the first magnetic resonance image or the second magnetic resonance image.

[0101] In one embodiment, the blood vessel image acquisition module 1106 is used to perform differential processing on the first magnetic resonance image and the second magnetic resonance image obtained by imaging the same layer to obtain an arterial blood vessel image and a venous blood vessel image respectively.

[0102] For the specific definition of the magnetic resonance imaging device and the vascular imaging device, please refer to the definition of the magnetic resonance imaging method and the vascular imaging method above, which will not be repeated here. Each module in the above-mentioned magnetic resonance imaging device and vascular imaging device can be implemented in whole or in part by software, hardware and a combination thereof. The above-mentioned modules can be embedded in or independent of the processor in the computer device in the form of hardware, or can be stored in the memory of the computer device in the form of software, so that the processor can call and execute the operations corresponding to the above modules.

[0103] In one embodiment, a computer device is provided. The computer device may be a terminal, and its internal structure diagram may be as follows: Fig.12As shown. The computer device includes a processor, a memory, a communication interface, a display screen and an input device connected through a system bus. Among them, the processor of the computer device is used to provide computing and control capabilities. The memory of the computer device includes a non-volatile storage medium and an internal memory. The non-volatile storage medium stores an operating system and a computer program. The internal memory provides an environment for the operation of the operating system and the computer program in the non-volatile storage medium. The communication interface of the computer device is used to communicate with an external terminal in a wired or wireless manner, and the wireless manner can be achieved through WIFI, an operator network, NFC (near field communication) or other technologies. When the computer program is executed by the processor, a magnetic resonance imaging method and a vascular imaging method are implemented. The display screen of the computer device can be a liquid crystal display screen or an electronic ink display screen, and the input device of the computer device can be a touch layer covered on the display screen, or a key, trackball or touchpad set on the computer device housing, or an external keyboard, touchpad or mouse, etc.

[0104] Those skilled in the art will understand that Fig.12 The structure shown in the figure is only a block diagram of a part of the structure related to the solution of the present application, and does not constitute a limitation on the computer device to which the solution of the present application is applied. The specific computer device may include more or fewer components than those shown in the figure, or combine certain components, or have a different arrangement of components.

[0105] In one embodiment, a computer device is provided, including a memory and a processor, wherein a computer program is stored in the memory, and the processor implements the following steps when executing the computer program: applying a first imaging sequence to obtain a first group of magnetic resonance signals of at least two layers, the first imaging sequence includes a simultaneous imaging sequence and a marking pulse whose application position is between at least two layers; applying a second imaging sequence to obtain a second group of magnetic resonance signals of at least two layers, the second imaging sequence includes a simultaneous imaging sequence, and no marking pulse is applied between at least two layers; and acquiring an arterial blood vessel image and a venous blood vessel image based on the first group of magnetic resonance signals and the second group of magnetic resonance signals.

[0106] In one embodiment, the application of the marking pulse involved in the execution of the computer program by the processor causes the arterial magnetic resonance signal at one level to have a lower intensity than the arterial magnetic resonance signal at another level; or causes the venous magnetic resonance signal at one level to have a higher intensity than the venous magnetic resonance signal at another level.

[0107] In one embodiment, the parameters of the marking pulse involved in the execution of the computer program by the processor are determined by the blood flow rate and the inversion time.

[0108] In one embodiment, the processor executes the computer program with the same or different number of slices on either side of the marking pulse.

[0109] In one embodiment, a computer device is provided, including a memory and a processor, wherein a computer program is stored in the memory, and the processor implements the following steps when executing the computer program: acquiring first magnetic resonance images of at least two layers using a simultaneous imaging sequence, wherein the first magnetic resonance image of one layer has arterial blood pixels and venous blood pixels with different signal intensities relative to the first magnetic resonance image of another layer; acquiring second magnetic resonance images of at least two layers using a simultaneous imaging sequence, wherein the second magnetic resonance image of one layer has arterial blood pixels and venous blood pixels with the same signal intensities relative to the second magnetic resonance image of another layer; and performing differential processing on the first magnetic resonance image and the second magnetic resonance image to acquire a blood vessel image.

[0110] In one embodiment, the generation method of the first magnetic resonance image or the second magnetic resonance image implemented when the processor executes the computer program includes: simultaneously exciting magnetic resonance signals of at least two layers; collecting magnetic resonance signals containing inter-layer aliasing; obtaining a reference image excited by a single layer; and using the reference image as a reference to perform anti-aliasing on the magnetic resonance signal to obtain the first magnetic resonance image or the second magnetic resonance image. In one embodiment, the differential processing of the first magnetic resonance image and the second magnetic resonance image implemented when the processor executes the computer program to obtain a vascular image includes: differential processing of the first magnetic resonance image and the second magnetic resonance image obtained by imaging the same layer to obtain an arterial vascular image and a venous vascular image, respectively.

[0111] In one embodiment, a computer-readable storage medium is provided, on which a computer program is stored, and when the computer program is executed by a processor, the following steps are implemented: applying a first imaging sequence to obtain a first group of magnetic resonance signals of at least two layers, the first imaging sequence includes a simultaneous imaging sequence and a marking pulse whose application position is between at least two layers; applying a second imaging sequence to obtain a second group of magnetic resonance signals of at least two layers, the second imaging sequence includes a simultaneous imaging sequence, and no marking pulse is applied between at least two layers; and acquiring an arterial blood vessel image and a venous blood vessel image based on the first group of magnetic resonance signals and the second group of magnetic resonance signals.

[0112] In one embodiment, the application of the marking pulse involved in the execution of the computer program by the processor causes the arterial magnetic resonance signal at one layer to have a lower intensity than the arterial magnetic resonance signal at another layer; or causes the venous magnetic resonance signal at one layer to have a higher intensity than the venous magnetic resonance signal at another layer.

[0113] In one embodiment, the computer program, when executed by the processor, involves parameters of the marking pulse being determined by blood flow rate and inversion time.

[0114] In one embodiment, the computer program is executed by the processor with the number of slices on either side of the marking pulse being the same or different.

[0115] In one embodiment, a computer-readable storage medium is provided, on which a computer program is stored, and when the computer program is executed by a processor, the following steps are implemented: using a simultaneous imaging sequence to acquire first magnetic resonance images of at least two layers, wherein the first magnetic resonance image of one layer has arterial blood pixels and venous blood pixels with different signal intensities relative to the first magnetic resonance image of another layer; using a simultaneous imaging sequence to acquire second magnetic resonance images of at least two layers, wherein the second magnetic resonance image of one layer has arterial blood pixels and venous blood pixels with the same signal intensities relative to the second magnetic resonance image of another layer; performing differential processing on the first magnetic resonance image and the second magnetic resonance image to acquire a vascular image.

[0116] In one embodiment, a method for generating a first magnetic resonance image or a second magnetic resonance image involved in the execution of a computer program by a processor includes: simultaneously exciting magnetic resonance signals of at least two layers; acquiring magnetic resonance signals containing inter-layer aliasing; acquiring a reference image excited by a single layer; and using the reference image as a reference to perform anti-aliasing on the magnetic resonance signal to obtain the first magnetic resonance image or the second magnetic resonance image.

[0117] In one embodiment, when a computer program is executed by a processor, differential processing of a first magnetic resonance image and a second magnetic resonance image is performed to obtain a vascular image, including: differential processing of the first magnetic resonance image and the second magnetic resonance image obtained by imaging at the same level to obtain an arterial vascular image and a venous vascular image, respectively.

[0118] Those of ordinary skill in the art can understand that all or part of the processes in the above-mentioned embodiment methods can be completed by instructing the relevant hardware through a computer program, and the computer program can be stored in a non-volatile computer-readable storage medium. When the computer program is executed, it can include the processes of the embodiments of the above-mentioned methods. Among them, any reference to memory, storage, database or other media used in the embodiments provided in this application can include at least one of non-volatile and volatile memory. Non-volatile memory can include read-only memory (ROM), magnetic tape, floppy disk, flash memory or optical memory, etc. Volatile memory can include random access memory (RAM) or external cache memory. As an illustration and not limitation, RAM can be in various forms, such as static random access memory (SRAM) or dynamic random access memory (DRAM).

[0119] The technical features of the above embodiments may be combined arbitrarily. To make the description concise, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0120] The above-mentioned embodiments only express several implementation methods of the present application, and the descriptions thereof are relatively specific and detailed, but they cannot be understood as limiting the scope of the invention patent. It should be pointed out that, for a person of ordinary skill in the art, several variations and improvements can be made without departing from the concept of the present application, and these all belong to the protection scope of the present application. Therefore, the protection scope of the patent of the present application shall be subject to the attached claims.

Claims

1. A magnetic resonance imaging method, characterized in that: The magnetic resonance imaging method comprises: Applying a first imaging sequence to acquire a first group of magnetic resonance signals of at least two layers, the first imaging sequence comprising a simultaneous imaging sequence and a marking pulse applied between at least two layers; applying the marking pulse causes an arterial magnetic resonance signal of one layer to have a lower intensity than an arterial magnetic resonance signal of another layer, or causes a venous magnetic resonance signal of one layer to have a higher intensity than a venous magnetic resonance signal of another layer; Applying a second imaging sequence to acquire a second set of magnetic resonance signals of at least two slices, wherein the second imaging sequence comprises a simultaneous imaging sequence and no labeling pulse is applied between the at least two slices; An arterial blood vessel image and a venous blood vessel image are acquired according to the first group of magnetic resonance signals and the second group of magnetic resonance signals.

2. The magnetic resonance imaging method according to claim 1, characterized in that: The parameters of the labeling pulse are determined by the blood flow rate and the inversion time.

3. The magnetic resonance imaging method according to claim 1, characterized in that: The number of slices on either side of the marking pulse may be the same or different.

4. A vascular imaging method, characterized in that: The vascular imaging method comprises: Acquire first magnetic resonance images of at least two layers by using a simultaneous imaging sequence, wherein the first magnetic resonance image of one layer has arterial blood pixels and venous blood pixels with different signal intensities relative to the first magnetic resonance image of another layer; Acquire second magnetic resonance images of the at least two layers by using a simultaneous imaging sequence, wherein the second magnetic resonance image of one layer has arterial blood pixels and venous blood pixels with the same signal intensity relative to the second magnetic resonance image of another layer; Performing differential processing on the first magnetic resonance image and the second magnetic resonance image to acquire a blood vessel image.

5. The vascular imaging method according to claim 4, characterized in that: The method for generating the first magnetic resonance image or the second magnetic resonance image comprises: Simultaneously exciting magnetic resonance signals of at least two levels; Acquiring magnetic resonance signals containing inter-layer aliasing; Acquire a reference image of a single slice excitation; The magnetic resonance signal is anti-aliased by using the reference image as a reference to obtain the first magnetic resonance image or the second magnetic resonance image.

6. The vascular imaging method according to claim 4, characterized in that: The step of performing differential processing on the first magnetic resonance image and the second magnetic resonance image to obtain a blood vessel image includes: The first magnetic resonance image and the second magnetic resonance image obtained by imaging at the same layer are differentially processed to obtain an arterial blood vessel image and a venous blood vessel image respectively.

7. A magnetic resonance imaging device, characterized in that: The magnetic resonance imaging apparatus comprises: a first group of magnetic resonance signal acquisition modules, configured to apply a first imaging sequence to acquire a first group of magnetic resonance signals of at least two layers, wherein the first imaging sequence comprises a simultaneous imaging sequence and a marking pulse whose application position is between at least two layers; the application of the marking pulse makes the arterial magnetic resonance signal of one layer have a lower intensity than the arterial magnetic resonance signal of another layer, or makes the venous magnetic resonance signal of one layer have a higher intensity than the venous magnetic resonance signal of another layer; a second group of magnetic resonance signal acquisition modules, configured to apply a second imaging sequence to acquire a second group of magnetic resonance signals of at least two slices, wherein the second imaging sequence comprises a simultaneous imaging sequence, and no marking pulse is applied between the at least two slices; The image generation module is used to acquire an arterial blood vessel image and a venous blood vessel image according to the first group of magnetic resonance signals and the second group of magnetic resonance signals.

8. A vascular imaging device, characterized in that: The vascular imaging device comprises: A first magnetic resonance image acquisition module, configured to acquire first magnetic resonance images of at least two layers by using a simultaneous imaging sequence, wherein the first magnetic resonance image of one layer has arterial blood pixels and venous blood pixels with different signal intensities relative to the first magnetic resonance image of another layer; A second magnetic resonance image acquisition module is used to acquire second magnetic resonance images of the at least two layers by using a simultaneous imaging sequence, wherein the second magnetic resonance image of one layer has arterial blood pixels and venous blood pixels with the same signal intensity as the second magnetic resonance image of another layer; The blood vessel image acquisition module is used to perform differential processing on the first magnetic resonance image and the second magnetic resonance image to acquire a blood vessel image.

9. A computer device comprising a memory and a processor, wherein the memory stores a computer program, wherein: When the processor executes the computer program, the steps of the method according to any one of claims 1 to 3 or 4 to 6 are implemented.

10. A computer-readable storage medium having a computer program stored thereon, characterized in that: When the computer program is executed by a processor, the steps of the method according to any one of claims 1 to 3 or 4 to 6 are implemented.

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