A common-field asynchronous biological tissue laser ablation device guided by OCT imaging

Abstract

The present invention discloses a common-field-of-view asynchronous biological tissue laser ablation device guided by optical coherence tomography (OCT). The device comprises a laser module, an OCT imaging module, and a lens; a galvanometer module comprising at least two galvanometers for controlling the laser light path and at least two galvanometers for controlling the detection light path, the galvanometers being located above the lens; and a control module for controlling the laser module, the OCT imaging module, and the galvanometer module. In some embodiments of the laser ablation device, OCT imaging and ablation can operate independently within the same field of view, without interfering with each other, making it more convenient to use.

Description

Technical Field

[0001] The present invention belongs to the field of laser ablation, and in particular relates to a common-viewing field asynchronous biological tissue laser ablation device under the guidance of OCT imaging. Background Art

[0002] Laser ablation is a new type of processing technology. The specific method is to use laser to irradiate the surface of the sample and remove part of the material through photothermal effect or photoacoustic effect.

[0003] Laser ablation has been widely used in clinical surgery in recent years, thanks to its high removal efficiency, the non-contact nature of the procedure, which prevents infection, and the high temperatures during the ablation process that can stop bleeding and sterilize bacteria. This includes the removal of soft tissues such as muscle and cornea, as well as hard tissues such as bone and teeth. However, laser ablation is a non-contact process, so the operator cannot assess the ablation depth in real time through touch. Furthermore, the roughness of the tissue surface after ablation is also important for subsequent treatment and requires real-time assessment.

[0004] Optical coherence tomography (OCT) is a non-contact, high-resolution optical imaging technology based on the coherence principle by detecting backscattered light. Studies have shown that OCT imaging technology can be used to guide the laser ablation process (Reference 1: Fan Y, Zhang B, Chang W, et al. A novel integration of spectral-domain optical-coherence-tomography and laser-ablation system for precision treatment[J]. International journal of computer assisted radiology and surgery, 2018, 13(3): 411-423.) and evaluate the surface properties of biological tissue after laser ablation (Reference 2: Huang W, Gao C, LanY, et al. Optical coherence tomography characterizes the roughness and thickness of the heterogeneous layer on cortical bone surface induced by Er:YAG laser ablation at different moisture contents[J]. Quantitative imaging inmedicine and surgery, 2020, 10(3): 713.). Existing OCT-guided laser ablation devices have two configurations: one uses a shared scanning unit, as described in Reference 1, requiring simultaneous imaging and ablation. Another uses separate systems, as described in Reference 2, requiring interactive imaging and ablation by moving the sample, making it difficult to maintain the same field of view. However, clinical treatment requires independent imaging and ablation within the same field of view, making neither of these devices sufficient. Summary of the Invention

[0005] The present invention aims to overcome at least one shortcoming of the prior art by providing an OCT-guided, shared-field-of-view asynchronous laser ablation device for biological tissue. This device can solve the problem of independently operating the OCT imaging guidance process and the biological tissue laser ablation process within the same field of view.

[0006] The technical solution adopted by the present invention is:

[0007] An OCT imaging-guided common-field asynchronous biological tissue laser ablation device comprises a laser module, an OCT imaging module, and a lens, and further comprises:

[0008] A galvanometer module, comprising at least two galvanometers for controlling the laser light path and at least two galvanometers for controlling the detection light path, wherein the galvanometers are located above the lens;

[0009] The control module is used to control the laser module, OCT imaging module and galvanometer module.

[0010] In some examples of common-field asynchronous biological tissue laser ablation devices guided by OCT imaging, the wavelength, operating mode, and power of the laser output by the laser module are adjustable.

[0011] In some examples of the common-field asynchronous biological tissue laser ablation device under OCT imaging guidance, the type of the OCT imaging module includes time-domain OCT, frequency-domain OCT, swept-frequency OCT or polarization OCT.

[0012] In some examples of common-field asynchronous biological tissue laser ablation devices under OCT imaging guidance, the galvanometer module is composed of two galvanometers for controlling the laser optical path and two galvanometers for controlling the detection light path. The two galvanometers controlling the laser optical path and the two galvanometers controlling the detection light path are cross-arranged.

[0013] In some examples of the common-view asynchronous biological tissue laser ablation device under OCT imaging guidance, the galvanometer includes a motor-type galvanometer, a MEMS-type galvanometer, or a resonant-type galvanometer.

[0014] In some examples of the common-view asynchronous biological tissue laser ablation device under the guidance of OCT imaging, the control module controls the laser module, the OCT imaging module and the galvanometer module in a wired or wireless manner.

[0015] In some examples of the common-field asynchronous biological tissue laser ablation device under OCT imaging guidance, the control module has data input and output functions.

[0016] In some examples of common-field asynchronous biological tissue laser ablation devices guided by OCT imaging, the control module controls the connection parts through multiple control cards or an integrated card.

[0017] In some examples of the common-field asynchronous biological tissue laser ablation device under the guidance of OCT imaging, the control module can control the laser module and the OCT imaging module to work separately or simultaneously.

[0018] In some examples of the common-field asynchronous biological tissue laser ablation device under OCT imaging guidance, the lens includes an optical glass lens, a liquid lens, or a liquid crystal lens.

[0019] The beneficial effects of the present invention are:

[0020] In the laser ablation devices of some embodiments of the present invention, OCT imaging and ablation can be independently performed in the same field of view without interfering with each other, making it more convenient to use. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Figure 1 Schematic diagram of some examples of common-field asynchronous biological tissue laser ablation devices under OCT imaging guidance of the present invention.

[0022] Figure 2 This is a schematic diagram of the scanning trajectory of the ablation laser and the detection light in the same field of view.

[0023] Reference numerals:

[0024] 1-Laser module, 2-OCT imaging module, 3-Control module, 4-Galvanometer module, 41, 42-Galvanometer, 5-Lens, 6-Biological tissue, 7-Lens field of view, 8-Ablation laser scanning trajectory, 9-Detection light scanning trajectory. DETAILED DESCRIPTION

[0025] The embodiments of the present invention are described in detail below. Examples of the embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals represent the same or similar elements or elements having the same or similar functions throughout. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain the present invention, and are not to be construed as limiting the present invention.

[0026] In the description of the present invention, it should be understood that descriptions involving orientations, such as up, down, front, back, left, right, etc., indicating orientations or positional relationships, are based on the orientations or positional relationships shown in the accompanying drawings. They are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation. Therefore, they cannot be understood as limitations on the present invention.

[0027] In the description of the present invention, "several" means one or more, "many" means more than two, "greater than," "less than," and "exceed" are understood to exclude the number itself, while "above," "below," and "within" are understood to include the number itself. The use of "first" and "second" in the description is solely for the purpose of distinguishing technical features and should not be construed as indicating or implying relative importance, implicitly specifying the number of the indicated technical features, or implicitly specifying the order of the indicated technical features.

[0028] Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be understood to indicate or imply relative importance or to implicitly indicate the quantity of the technical features indicated. Thus, features defined as "first" and "second" may explicitly or implicitly include one or more features.

[0029] In the description of the present invention, it should be noted that, unless otherwise clearly specified and limited, the term "connection" should be understood in a broad sense. For example, it can be a fixed connection or a movable connection, a detachable connection or a non-detachable connection, or an integral connection; it can be a mechanical connection, an electrical connection, or mutual communication; it can be a direct connection, or an indirect connection through an intermediate medium, and it can be internal communication between two elements, indirect communication, or an interactive relationship between two elements.

[0030] The following disclosure provides many different embodiments or examples for implementing different solutions of the present invention.

[0031] Reference Figure 1 A common-view asynchronous biological tissue laser ablation device under OCT imaging guidance includes a laser module 1, an OCT imaging module 2, and a lens 5, and further includes:

[0032] The galvanometer module 4 includes at least two galvanometers for controlling the laser light path and at least two galvanometers for controlling the detection light path, and the galvanometers are located above the lens 5;

[0033] The control module 3 is used to control the laser module 1 , the OCT imaging module 2 and the galvanometer module 4 .

[0034] The laser module is used to output laser light for biological tissue ablation, the OCT imaging module uses detection light to scan and image biological tissue, and the lens is used to focus the ablation laser and detection light onto the surface of biological tissue.

[0035] Different tissues have different responses to lasers. In order to meet the ablation needs of different tissues, in some examples of common-field asynchronous biological tissue laser ablation devices guided by OCT imaging, the wavelength, working mode, and power of the laser output by the laser module 1 are adjustable.

[0036] There is no particular limitation on the type of OCT imaging. In some examples of common-field asynchronous biological tissue laser ablation devices guided by OCT imaging, the type of the OCT imaging module 2 includes but is not limited to time-domain OCT, frequency-domain OCT, swept-frequency OCT or polarization OCT.

[0037] In some examples of common-field asynchronous biological tissue laser ablation devices guided by OCT imaging, the galvanometer module 4 is composed of two galvanometers 41 for controlling the laser light path and two galvanometers 41 for controlling the detection light path. The two galvanometers for controlling the laser light path and the two galvanometers for controlling the detection light path are cross-arranged, so that the ablation laser and the detection light can scan the same area under the lens respectively. This can not only realize the control of the light path, but also simplify the design of the light path. If necessary, the corresponding galvanometers can be set as needed to obtain more adjustment flexibility. In a specific example, under the same lens field of view 7, the ablation laser scanning trajectory 8 and the detection light scanning trajectory 9 can be orthogonal. Of course, the scanning trajectory can also be at other angles.

[0038] The type of galvanometer is not particularly limited. In some examples of common-field asynchronous biological tissue laser ablation devices guided by OCT imaging, the galvanometer includes but is not limited to a motor-type galvanometer, a MEMS-type galvanometer or a resonant-type galvanometer.

[0039] In some examples of OCT-guided, common-field asynchronous laser ablation devices for biological tissue, the control module 3 controls the laser module 1, OCT imaging module 2, and galvanometer module 4 in a wired or wireless manner. Wired control offers greater anti-interference capabilities and lower latency, making it a preferred option.

[0040] In some examples of the common-field asynchronous biological tissue laser ablation device under the guidance of OCT imaging, the control module 3 has data input and output functions.

[0041] In some examples of common-field asynchronous biological tissue laser ablation devices guided by OCT imaging, the control module 3 controls the connection parts through multiple control cards or an integrated card.

[0042] In some examples of common-field asynchronous biological tissue laser ablation devices guided by OCT imaging, the control module 3 can control the laser module 1 and the OCT imaging module 2 to work individually or simultaneously.

[0043] The lens can be a lens commonly used in the field of laser ablation, and there is no particular requirement for its type. In some examples of common-view asynchronous biological tissue laser ablation devices guided by OCT imaging, the lens 5 includes an optical glass lens 5, a liquid lens 5, or a liquid crystal lens 5.

[0044] Example 1:

[0045] A common-field asynchronous biological tissue laser ablation device under OCT imaging guidance includes a laser module 1, an OCT imaging module 2, a control module 3, a galvanometer module 4 and a lens 5. The galvanometer module 4 is located above the lens 5 and is composed of two galvanometers 41 for controlling the laser light path and two galvanometers 42 for controlling the detection light path. The two galvanometers controlling the laser light path and the two galvanometers controlling the detection light path are arranged crosswise.

[0046] When using, you can refer to the following steps:

[0047] The biological tissue sample (6) to be ablated is placed below the lens (5);

[0048] The control module (3) controls the OCT imaging module (2) and the scanning galvanometer module (4) to image the surface of the biological sample within the full field of view of the lens (5);

[0049] The control module (3) controls the laser module (1) and the scanning galvanometer module (4) according to the input parameters to perform laser ablation on a certain area on the surface of the biological sample within the field of view of the lens (5);

[0050] During the ablation process, the control module (3) adjusts the parameters of the laser module (1) and the scanning galvanometer module (4) in real time according to the results of the OCT imaging module (2);

[0051] After the ablation is completed, the control module (3) controls the laser module (1) to stop working first, and the OCT imaging module (2) stops working after completing the evaluation.

[0052] The above is a further detailed description of the present invention and should not be considered as a limitation on the specific implementation of the present invention. For those skilled in the art, simple deductions or substitutions that do not depart from the concept of the present invention are within the scope of protection of the present invention.

Claims

1. A common-field asynchronous biological tissue laser ablation device under OCT imaging guidance, comprising a laser module, an OCT imaging module and a lens, characterized in that: Also includes: A galvanometer module, comprising at least two galvanometers for controlling the laser light path and at least two galvanometers for controlling the detection light path, the galvanometers being located above the lens. The galvanometer module is composed of the two galvanometers for controlling the laser light path and the two galvanometers for controlling the detection light path, and the two galvanometers for controlling the laser light path and the two galvanometers for controlling the detection light path are arranged crosswise; The control module is used to control the laser module, OCT imaging module and galvanometer module.

2. The common-view asynchronous biological tissue laser ablation device according to claim 1, characterized in that: The wavelength, working mode and power of the laser output by the laser module are adjustable.

3. The common-view asynchronous biological tissue laser ablation device according to claim 1, characterized in that: The types of the OCT imaging module include time domain OCT, frequency domain OCT, swept frequency OCT or polarization OCT.

4. The common-view asynchronous biological tissue laser ablation device according to claim 1, characterized in that: The galvanometer mirror includes a motor-type galvanometer mirror, a MEMS-type galvanometer mirror or a resonance-type galvanometer mirror.

5. The common-view asynchronous biological tissue laser ablation device according to any one of claims 1 to 4, characterized in that: The control module controls the laser module, the OCT imaging module and the galvanometer module in a wired or wireless manner.

6. The common-view asynchronous biological tissue laser ablation device according to claim 5, characterized in that: The control module has data input and output functions.

7. The common-view asynchronous biological tissue laser ablation device according to claim 5, characterized in that: The control module controls the connection parts through multiple control cards or an integrated card.

8. The common-view asynchronous biological tissue laser ablation device according to claim 5, characterized in that: The control module can control the laser module and the OCT imaging module to work individually or simultaneously.

9. The common-view asynchronous biological tissue laser ablation device according to any one of claims 1 to 4, characterized in that: The lens includes an optical glass lens, a liquid lens or a liquid crystal lens.

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