Embolus extraction device

Abstract

The thrombectomy device of the present invention includes a push-pull guide wire and a stent. The stent includes a capture section. The capture section is integrally in a cylindrical structure. After the cylindrical structure is unfolded and flattened, an unfolded structure of the capture section is formed. The unfolded structure can be spirally formed into a cylindrical structure around the axial direction of the capture section. At least one capture assembly is provided on the capture section. The capture assembly includes a plurality of capture members, and the plurality of capture members are sequentially arranged in a spiral shape along the axial direction of the capture section in the cylindrical structure. The thrombectomy device of the present invention has good bending performance and wall attachment performance, can reduce or avoid causing detachment of thrombus or cutting thrombus, thereby driving the thrombus to pass through the curved blood vessel together, and ensuring the complete removal of the thrombus from the blood vessel.

Description

Technical Field

[0001] The present invention belongs to the technical field of medical devices, and in particular relates to a thrombus removal device. Background Art

[0002] Acute ischemic stroke (AIS, commonly known as cerebral infarction) is a neurological injury caused by local ischemic necrosis of brain tissue due to sudden blockage of cerebral blood flow. Acute ischemic stroke is the most common type of stroke and the main cause of death and disability in the middle-aged and elderly. In particular, acute stroke caused by large vessel occlusion is a serious disease with high mortality and disability rates. Once a stroke occurs, it causes great physical and mental harm to the patient, and also imposes a heavy burden on the patient's family and society.

[0003] At present, the clinical treatment of ischemic stroke mainly adopts mechanical thrombectomy, which is to deliver a thrombectomy device to the lesion site, use the thrombectomy device to grab the thrombus and remove it from the body.

[0004] Combination Figure 1 , Figure 2 and Figure 3 As shown, the existing thrombus remover 300 includes a microcatheter 330, a push-pull guide wire 310 and a thrombus remover stent 320, and the distal end of the microcatheter 330 has a first imaging mark 340. The push-pull guide wire 310 is connected to the thrombus remover stent 320, and the connected push-pull guide wire 310 and the thrombus remover stent 320 are pressed into the microcatheter 330. The thrombus remover stent 320 forms a compressed state, and the thrombus remover stent 320 can be transformed between a retracted position and an extended position by pushing and pulling the push-pull guide wire 310. In the retracted position, the thrombus remover stent 320 is retracted into the microcatheter 330. In the extended position, the thrombus remover stent 320 is pushed out of the microcatheter 330.

[0005] The thrombectomy device 300 reaches the thrombus 500 from the proximal end through minimally invasive surgery and by pushing and pulling the guide wire 310 through the blood vessel 400. It passes through the thrombus 500 from the proximal end of the thrombus 500. Under the observation of imaging devices such as CT and / or MRA, DSA, etc., the distance between the first imaging marker 340 of the microcatheter 330 and the thrombus 500 is 5 - 40 mm. Fix the push-pull guide wire 310, retract the microcatheter 330 to the outside of the body, and check the first imaging marker 340 under the monitoring of the imaging device to know the retraction path of the microcatheter 330 in the body. Due to the retraction of the microcatheter 330, the thrombectomy stent 320 in the compressed state is pushed out of the microcatheter 330 and returns to the expanded state. After fixing the push-pull guide wire 310 for a period of time to allow the thrombectomy stent 320 to expand sufficiently, through the self-expanding radial force of the thrombectomy stent 320, the mesh rods of the thrombectomy stent 320 penetrate into the thrombus 500 and are in full contact with the thrombus 500. Retract the push-pull guide wire 310. Under the pulling of the push-pull guide wire 310, the thrombectomy stent 320 moves towards the proximal end, and the thrombectomy stent 320 drives the thrombus 500 to move towards the proximal end together. When the push-pull guide wire 310 drives the thrombectomy stent 320 to retract to the second imaging marker 610 of the retrieval catheter 600, and the push-pull guide wire 310 continues to retract, the thrombectomy stent 320 and the captured thrombus 500 are pulled into the retrieval catheter 600. Then, the retrieval catheter 600 and the thrombectomy device 300 and the thrombus 500 in the retrieval catheter 600 are withdrawn as a whole to the outside of the patient's body, and the entire thrombectomy process is completed.

[0006] However, when the thrombectomy stent 320 drives the thrombus 500 to retract and passes through the curved blood vessel 400, the thrombectomy stent 320 is prone to collapse under the extrusion of the thrombus 500 and the blood vessel 400, resulting in the separation between the thrombus 500 and the thrombectomy stent 320 or the thrombus 500 being cut by the thrombectomy stent 320 to form small thrombus blocks, leading to the escape of the thrombus 500 and causing serious harm to the patient. Summary of the Invention

[0007] The object of the present invention is to at least solve the problem of poor bending performance of the thrombectomy stent. This object is achieved in the following way:

[0008] The present invention provides a thrombectomy device, which includes:

[0009] A push-pull guide wire;

[0010] A stent, which is connected to the push-pull guide wire. The stent includes a capture section. The capture section is integrally in a cylindrical structure. The unfolded structure of the capture section is formed after the cylindrical structure is unfolded and flattened. The unfolded structure can be spirally formed into the cylindrical structure around the axial direction of the capture section. At least one capture component is provided on the capture section. The capture component includes a plurality of capture elements, and the plurality of capture elements are sequentially arranged in a spiral shape along the axial direction of the capture section in the cylindrical structure.

[0011] According to the above-mentioned thrombectomy device, the stent includes a capture section. The capture section is integrally in a cylindrical structure. After the cylindrical structure is unfolded and flattened, it forms the unfolded structure of the capture section. The unfolded structure can be spirally formed into a cylindrical structure around the axial direction of the capture section, making the whole structure special. In addition, the capture section includes at least one capture assembly provided with a plurality of capture members. Through the above-mentioned spiral process, the whole capture assembly can be in a spiral structure, and thus the whole capture assembly has good bending performance. The plurality of capture members can be sequentially arranged in a spiral shape along the axial direction of the capture section, and can better fit the blood vessel wall. Specifically, when the capture section withdraws after capturing a thrombus through the opening between adjacent capture members, it is easy to bend when the capture section passes through a curved blood vessel. The plurality of capture members better fit the curved blood vessel wall, effectively reducing or avoiding the gap between the capture section and the curved blood vessel, reducing or avoiding the detachment or cutting of the thrombus, so as to drive the thrombus to pass through the curved blood vessel together, ensuring the complete removal of the thrombus from the blood vessel and ensuring the safety and reliability of the use of the thrombectomy device.

[0012] In addition, according to the thrombectomy device of the present invention, the following additional technical features may also be provided:

[0013] In some embodiments of the present invention, in the unfolded structure of the capture section, the plurality of capture members of the same capture assembly are sequentially arranged along a first straight line direction, and the first straight line direction is arranged at an angle with the axial direction of the stent.

[0014] In some embodiments of the present invention, in the capture section, all the capture members are arranged in a spiral shape along the axial direction of the capture section.

[0015] In some embodiments of the present invention, the number of the capture assemblies is multiple, and in the unfolded structure, two adjacent capture assemblies are arranged parallel to each other.

[0016] In some embodiments of the present invention, in the unfolded structure, two adjacent capture members of the two capture assemblies are arranged side by side in a direction perpendicular to the length direction of the unfolded structure, so that there are at least two capture members on at least one cross-section of the formed cylindrical structure.

[0017] In some embodiments of the present invention, in the unfolded structure, two adjacent capture members of the two capture assemblies are arranged at intervals in the length direction of the unfolded structure, so that in the formed cylindrical structure, the two adjacent capture members are located on different cross-sections of the cylindrical structure.

[0018] In some embodiments of the present invention, the stent is further provided with a grid structure. In the unfolded structure,

[0019] In a direction perpendicular to the longitudinal direction in the deployment structure, the grid structure is arranged side by side with the capture assembly; or / and, the capture member is arranged in the grid structure.

[0020] In some embodiments of the present invention, the stent further includes a support section or / and an anti-detachment section, the support section, the capture section and the anti-detachment section are sequentially connected along the axial direction of the stent, and the push-pull guide wire is connected to the proximal end of the stent.

[0021] In some embodiments of the present invention, the stent is integrally in a stent tubular structure, the stent tubular structure forms a stent deployment structure after being deployed and flattened, the stent deployment structure can be spirally formed into the stent tubular structure around the axial direction of the stent, and the longitudinal direction of the stent deployment structure is arranged at an angle to the axial direction of the stent tubular structure.

[0022] In some embodiments of the present invention, the capture member includes a first stent rod and a second stent rod, and the ends of the first stent rod and the second stent rod away from the push-pull guide wire converge at a point to form a free end. Description of the Drawings

[0023] By reading the following detailed description of the preferred embodiments, various other advantages and benefits will become clear to those of ordinary skill in the art. The drawings are only for the purpose of showing the preferred embodiments and are not considered to be a limitation of the present invention. Moreover, throughout the drawings, the same reference numerals are used to represent the same components. Among them:

[0024] Figure 1 is a schematic structural diagram of a thrombectomy device in the prior art;

[0025] Figure 2 is Figure 1 a schematic structural diagram of the thrombectomy device in after passing through the thrombus in the blood vessel;

[0026] Figure 3 is Figure 1 a schematic structural diagram of the thrombectomy device during thrombectomy in ;

[0027] Figure 4 is a schematic structural diagram of Embodiment 1 of the thrombectomy device of the present application;

[0028] Figure 5 is Figure 4 a schematic structural diagram of the stent in the deployed structure in ;

[0029] Figure 6 is Figure 4 an enlarged schematic structural diagram of part a in ;

[0030] Figure 7 is Figure 4 a partial structural schematic diagram of the capture section in

[0031] Figure 8 is Figure 4 a schematic diagram of the circumferential distribution structure of the capture section in

[0032] Figure 9 is Figure 4 a structural schematic diagram of the support section in

[0033] Figure 10 is Figure 4 a structural schematic diagram of the leak-proof section in

[0034] Figure 11 is a structural schematic diagram of the second embodiment of the thrombectomy device of the present application;

[0035] Figure 12 is Figure 11 a structural schematic diagram of the stent in the deployed structure in

[0036] Figure 13 is Figure 11 an enlarged structural schematic diagram of part b in

[0037] Figure 14 is a structural schematic diagram of the third embodiment of the thrombectomy device of the present application;

[0038] Figure 15 is Figure 14 a structural schematic diagram of the stent when it is in the deployed structure in

[0039] Figure 16 is Figure 14 an enlarged structural schematic diagram of part c in Specific Embodiments

[0040] The exemplary embodiments of the present invention will be described in more detail below with reference to the accompanying drawings. Although the exemplary embodiments of the present invention are shown in the drawings, it should be understood that the present invention can be implemented in various forms and should not be limited by the embodiments set forth herein. On the contrary, these embodiments are provided so that the present invention can be more thoroughly understood and the scope of the present invention can be completely conveyed to those skilled in the art.

[0041] It should be understood that the terms used herein are for the purpose of describing particular example embodiments only and are not intended to be limiting. Unless the context clearly dictates otherwise, the singular forms "a", "an", and "the" as used herein may also include the plural forms. The terms "comprising", "including", "containing", and "having" are inclusive and thus specify the presence of stated features, steps, operations, elements, and / or components, but do not preclude the presence or addition of one or more other features, steps, operations, elements, components, and / or combinations thereof. The method steps, processes, and operations described herein are not to be construed as necessarily requiring their performance in the particular order described or illustrated, unless explicitly indicated as an order of performance. It should also be understood that additional or alternative steps may be used.

[0042] Although the terms first, second, third, etc. may be used herein to describe multiple elements, components, regions, layers, and / or sections, these elements, components, regions, layers, and / or sections should not be limited by these terms. These terms may be used only to distinguish one element, component, region, layer, or section from another. Unless the context clearly indicates otherwise, terms such as "first", "second", and other numerical terms when used herein do not imply an order or sequence. Thus, the first element, component, region, layer, or section discussed below may be referred to as the second element, component, region, layer, or section without departing from the teachings of the example embodiments.

[0043] For ease of description, spatial relative relationship terms may be used herein to describe the relationship of one element or feature shown in the figures to another element or feature, such as "inner", "outer", "inside", "outside", "below", "beneath", "above", "over", etc. Such spatial relative relationship terms are intended to include different orientations of the device in use or operation in addition to the orientation depicted in the figures. For example, if the device in the figures is flipped, an element described as "below" or "beneath" another element or feature will then be oriented "above" or "over" the other element or feature. Thus, the example term "below" can include both an orientation above and below. The device may be otherwise oriented (rotated 90 degrees or in other directions) and the spatial relative relationship descriptors used herein are to be interpreted accordingly.

[0044] To more clearly describe the structure of the present application, the terms "proximal" and "distal" are defined herein as terms commonly used in the field of interventional medicine. Specifically, "distal" refers to the end away from the operator during a surgical operation, "proximal" refers to the end close to the operator during a surgical operation, "axial" refers to its length direction, and "radial" refers to the direction perpendicular to the "axial" direction.

[0045] Embodiment 1

[0046] When the thrombectomy device 100 of this embodiment performs thrombectomy, it can be used in conjunction with the structures of the microcatheter 330 and the retrieval catheter 600 in the prior art such as Figure 2 and Figure 3 . In combination with Figure 2 , Figure 3 and Figure 4 shown, the thrombectomy device 100 of this embodiment includes a push-pull guide wire 10 and a stent 20. During actual use, the push-pull guide wire 10 is arranged closer to the operator than the stent 20. The push-pull guide wire 10 is connected to the proximal end of the stent 20, and the position of the stent 20 in the blood vessel 400 is controlled by proximally manipulating the push-pull guide wire 10.

[0047] The stent 20 in this application is a self-expanding stent, which has a compressed state and an expanded state. When the stent 20 is transported in the microcatheter 330, the stent 20 is compressed in the microcatheter 330 and is in a compressed state. When the microcatheter 330 is withdrawn, the stent 20 is exposed to the outside of the microcatheter 330. The stent 20 expands and deforms under the action of its own radial force, and finally reaches the expanded state. The stent 20 in the expanded state has a cylindrical structure, and a lumen is formed inside it.

[0048] Referring to Figure 4 , the stent 20 includes a support section 21, a capture section 22, and a leak prevention section 23, where the support section 21, the capture section 22, and the leak prevention section 23 are sequentially connected along the axial direction of the stent 20. For clarity, Figure 4 in, section A represents the length of the support section 21, section B represents the length of the capture section 22, and section C represents the length of the leak prevention section 23. In other embodiments, the stent 20 may only include the capture section 22, or the stent 20 may only include the capture section 22 and the support section 21, or the stent 20 may only include the capture section 22 and the leak prevention section 23.

[0049] Combined with Figure 4 and Figure 5 , where Figure 4 shows the natural state of the stent 20. The natural state refers to the state presented when the stent 20 is placed naturally and not under the compression of force (except for the action of gravity). In this natural state, the stent as a whole has a cylindrical structure, and the capture section 22 also has a cylindrical structure. The cylindrical structure of the capture section 22 can be heat-set; Figure 5Shown is the deployed structure of the stent 30. After the tubular structure of the stent 30 is deployed and flattened, it can form the deployed structure of the stent 30. Among them, the deployed structure of the capture section 22 can be spirally formed into the tubular structure of the capture section 22 around the axial direction of the capture section 22. That is, the tubular structure of the capture section 22 can be unspirally deployed and flattened around the axial direction of the capture section 22 to form the deployed structure of the capture section 22.

[0050] Among them, a capture assembly 221 is provided on the capture section 22. The capture assembly 221 includes a plurality of capture elements 222. The plurality of capture elements 222 are arranged in sequence in a spiral shape along the axial direction of the capture section 22, so that it has better bending performance compared with the existing mesh frame type stent. At the same time, the plurality of capture elements 222 arranged in sequence in a spiral shape have better wall attachment performance. Among them, the plurality of capture elements 222 are arranged in sequence in a spiral shape along the axial direction of the capture section 22, which can be understood as that the connection line of the plurality of capture elements 222 from the proximal end to the distal end along the axial direction of the capture section 22 is spiral.

[0051] According to the thrombectomy device 100 of the present embodiment, the stent 20 includes a capture section 22. The capture section 22 is integrally in a tubular structure. After the tubular structure is deployed and flattened, it forms the deployed structure of the capture section 22. The deployed structure of the capture section 22 can be spirally formed into a tubular structure around the axial direction of the capture section 22, making the whole structure special. In addition, the capture section 22 includes at least one capture assembly 221 provided with a plurality of capture elements 222. Through the above spiral process, the capture assembly 221 is integrally in a spiral structure, and thus the capture assembly 221 as a whole has good bending performance. The plurality of capture elements 222 are arranged in sequence in a spiral shape along the axial direction of the capture section 22, and can better fit with the blood vessel wall. When the capture section 22 withdraws after capturing the thrombus 500 through the opening between adjacent capture elements 222, it is easy to bend when the capture section 22 passes through the curved blood vessel 500. The plurality of capture elements 222 better fit with the inner wall of the blood vessel 400, effectively reducing or avoiding the gap between the capture section 22 and the curved blood vessel 400, reducing or avoiding the detachment of the thrombus 500 or cutting the thrombus 500, thereby driving the thrombus 500 to pass through the curved blood vessel 400 together, ensuring the complete removal of the thrombus 500 from the blood vessel 300, and ensuring the safety and reliability of the use of the thrombectomy device 100.

[0052] Such as Figure 5As shown, by disconnecting the connection between the support section 21 and the capture section 22 and the connection between the capture section 22 and the leak-proof section 23, the cylindrical structure of the capture section 22 is unwound and flattened around the axial direction of the capture section 22 to form the unfolded structure of the capture section 22. Among them, to disconnect the connection between the support section 21 and the capture section 22, one or several connecting rods between the support section 21 and the capture section 22 can be disconnected, or all the connecting rods between the support section 21 and the capture section 22 can be disconnected; to disconnect the connection between the capture section 22 and the leak-proof section 23, one or several connecting rods between the capture section 22 and the leak-proof section 23 can be disconnected, or all the connecting rods between the capture section 22 and the leak-proof section 23 can be disconnected. For the above disconnection methods, as long as the cylindrical structure of the capture section 22 can be unwound and flattened around the axial direction of the capture section 22 to form the unfolded structure of the capture section 22.

[0053] A plurality of capture members 222 of the capture assembly 221 in the unfolded state are arranged in sequence along the first straight line direction Z1, and the first straight line direction Z1 is set at an angle d with the axial direction Z2 of the bracket. Among them, the value range of the included angle d formed by the first straight line direction Z1 and the axial direction Z2 of the bracket is 5 to 60 degrees. In this embodiment, the included angle d is 45 degrees. If the included angle d is greater than the value range, the spiral structure formed after the unfolded structure of the capture section 22 is curled is compact, that is, the gap between the spiral structures formed by two adjacent capture members 222 is small, thus affecting the setting of the capture members 222. If the included angle d is less than the value range, the unfolded structure of the capture section 22 is not easily curled to form a spiral structure. In this embodiment, the number of capture members 222 is determined according to the total length of the bracket 20, and is preferably 4 to 8.

[0054] In this embodiment, different from the capture section 22, the length directions of the support section 21 and the leak-proof section 23 after unfolding are the same as the axial direction Z2 of the bracket. It can be understood that in addition to disconnecting the connection between the support section 21 and the capture section 22 and the connection between the capture section 22 and the leak-proof section 23, during the unfolding process of the support section 21 and the leak-proof section 23, if necessary (determined according to the structures of the support section 21 and the leak-proof section 23), the support section 21 and the leak-proof section 23 need to be disconnected again along the axial direction Z2 of the bracket.

[0055] In Figure 5 When the capture section 22 is in the unfolded state, each capture member 222 is distributed along the gradient of the included angle d. There is a spacing L1 between two adjacent capture members 222 arranged adjacent to each other in the axial direction Z2 of the bracket, and a spacing L2 in the direction perpendicular to the axial direction Z2 of the bracket. Since the total length of the bracket 20 is certain, that is, the length B of the capture section 22 is certain, and the length of the unfolded capture section 22 along the axial direction Z2 of the bracket is also B. Then, according to the number of capture members 222 and the included angle d, the dimensions of L1 and L2 can be calculated.

[0056] AsFigure 6 As shown, the capture member 222 of the present application includes a first support rod 223 and a second support rod 224. One ends of the first support rod 223 and the second support rod 224 facing the push-pull guide wire 10 are respectively connected to different connection points in the capture section 22 to form a connection end; the other ends of the first support rod 223 and the second support rod 224 away from the push-pull guide wire 10 converge at a point to form a free end 220. In this embodiment, the free end 220 can be further extended to form a free end rod-shaped structure.

[0057] Referring again to Figure 5 , when the capture section 22 is in the deployed state, one ends of the first support rod 223 and the second support rod 224 facing the push-pull guide wire 10 are respectively connected to the adjacent support section 21 or the adjacent capture member 222. The other ends of the first support rod 223 and the second support rod 224 away from the push-pull guide wire 10 converge at a point and form a free end 220. Specifically, the connection points between two adjacent capture members 222 are at the middle position or a position close to the middle of the first support rod 223 and the second support rod 224. When passing through a curved blood vessel segment, the capture section 22 bends and deforms along with the stent 20, and the connection ends of the capture member 222 bend and deform together with the capture section 22, while the free end 220 of the capture member 222 remains in the state of protruding outward. In this way, no matter how the stent 20 bends and deforms in any direction in the blood vessel 400, there is always a part of the structure (at least the free end 220 of the capture member 222) on the capture section 22 in contact with the inner wall of the blood vessel 400, thereby preventing a gap from being generated between the capture section 22 and the inner wall of the blood vessel 400 after bending, and reducing or avoiding the escape of the captured thrombus 500.

[0058] In the present application, any capture member 222 composed of the first support rod 223 and the second support rod 224 is arranged in a spiral shape along the axial direction of the capture section 22, so as to improve the bending performance of the capture member 222, and further improve the bending performance and wall attachment performance of the capture section 22. Among them, a plurality of capture members 222 are arranged in a spiral shape in sequence along the axial direction of the capture section 22. It can be understood that the connection line of a plurality of capture members 222 along the axial direction of the capture section 22 from the proximal end to the distal end is spiral. In the implementation manner of the present application, the capture member 222 can also be arranged in a circular shape or other continuous annular structures, and a plurality of capture members 222 are arranged in a spiral shape in sequence along the axial direction of the capture section 22, which can also improve the bending performance and wall attachment performance of the capture section 22.

[0059] Further, referring to Figure 7, a first developing unit 226 is provided on the free end 220 of the capture member 222. The first developing unit 226 can be made of a pure metal or alloy with a relatively high molecular weight, such as platinum, gold, platinum-iridium alloy, platinum-tungsten alloy, etc. The first developing unit 226 can be a spring structure or a tubular structure sleeved on the distal end of the capture member 222. In this embodiment, the first developing unit 226 is sleeved on the rod-shaped structure of the free end. In other embodiments, the first developing unit 226 can be directly connected to the free end 220 of the capture member 222 by means such as welding.

[0060] Further, the capture assembly 221 of this embodiment is provided with a plurality of capture members 222, so it includes the free ends 220 of a plurality of capture members 222. The free ends 220 of the plurality of capture members 222 are equidistantly arranged along the circumferential direction of the capture section 22. According to the different sizes of the above L1 and L2, an angle e can be formed between the free ends 220 of the capture members 222 in the circumferential direction after being spiraled, as Figure 8 shown. Therefore, the number of the capture members 222 can also be evenly arranged according to the angle e on the circumference.

[0061] As Figure 9 shown, the support section 21 of this embodiment includes a first wire frame 211. The proximal end of the capture section 22 is connected to the distal end of the first wire frame 211. A third support rod 212 is provided at the proximal end of the first wire frame 211. The third support rod 212 is connected to the push-pull guide wire 10, thereby realizing the connection between the push-pull guide wire 10 and the stent 20. The connection manner between the third support rod 212 and the push-pull guide wire 10 can be welding, bonding, press riveting, etc., or a movable connection, which is not limited here.

[0062] To ensure that the stent 20 can enter a smaller microcatheter, the diameter of the push-pull guide wire 10 should not exceed 0.5 mm. In this embodiment, the diameter range is 0.05 - 0.4 mm. The push-pull guide wire 10 can be made of a metal with good elasticity, including stainless steel, nickel-titanium alloy, cobalt-chromium alloy, etc.

[0063] A plurality of first mesh holes 213 are also provided on the first wire frame 211. The first mesh holes 213 are communicated with the internal lumen of the first wire frame 211. Compared with the capture section 22, the support section 21 has a stronger radial support force. The support section 21 provides support for the capture section 22 at the proximal end of the stent 20, so as to ensure that the capture section 22 is in an expanded state after being separated from the microcatheter 330. In this application, the support section 21 provides support for the capture section 22. To make the support section 21 have a stronger radial support force, the rod width dimension of the support section 21 along the circumferential direction can be widened, or the wall thickness dimension of the support section 21 along the radial direction can be thickened, or a denser mesh structure can be adopted, or the support section 21 has a larger radial diameter dimension compared with the capture section, or a combination of the above several methods.

[0064] As Figure 10 shown, the anti-leakage section 23 of this embodiment includes a second wire frame 231, and the second wire frame 231 is connected to the distal end of the capture section 22. A plurality of second mesh holes 232 for capturing thrombus 500 are provided on the second wire frame 231, and the average area of the mesh holes of the second mesh holes 232 is smaller than the average area of the mesh holes of the capture section (referring to all the openings in the cylindrical structure of the capture section). When the thrombus 500 on the capture section 22 becomes detached or is cut into pieces, it can be captured again through the second mesh holes 232 on the anti-leakage section 23. Since the average area of the mesh holes of the second mesh holes 232 is smaller than the average area of the mesh holes of the capture section, the fixation of the thrombus 500 is more secure and the thrombus 500 is not easily escaped.

[0065] Furthermore, as Figure 10 shown, a plurality of fourth support rods 233 are further provided at the distal end of the anti-leakage section 23 of the present application. The distal ends of the plurality of fourth support rods 233 converge at a point to form the distal end of the anti-leakage section 23, thereby forming a structure similar to a net pocket at the distal end of the anti-leakage section 23, and further collecting and fixing the thrombus 500 that has fallen off from the capture section 22 inside the anti-leakage section 23. In this embodiment, the distal end of the anti-leakage section 23 can further extend distally to form a rod-shaped structure at the distal end of the anti-leakage section 23.

[0066] Furthermore, a second imaging unit 234 is provided at the distal end of the anti-leakage section 23. The second imaging unit 234 can be made of a pure metal or alloy with a relatively high molecular weight, such as platinum, gold, platinum-iridium alloy, platinum-tungsten alloy, etc. The second imaging unit 234 can be a spring structure or a tubular structure sleeved on the distal end of the anti-leakage section 23, thereby forming a guiding section at the distal end of the anti-leakage section 23 for guiding the overall movement of the stent 20 along the direction of the blood vessel 400.

[0067] Again, as Figure 4 shown, the overall length of the thrombus extraction device 100 of the present application is 20-70 mm. The length of the capture section 22 is greater than the length of the support section 21, and at the same time, the length of the capture section 22 is greater than the length of the anti-leakage section 23. The length range of the capture section 22 is 10% - 90% of the total length of the stent 20. In this embodiment, the length range of the capture section 22 is 33% - 66% of the total length of the stent 20. The maximum diameter dimension range of the stent 20 perpendicular to the stent axial direction Z2 is 2-7 mm, and the thickness dimension range of the pipe or sheet for preparing or forming the stent 20 is 0.05-0.5 mm.

[0068] Combined with Figures 1 to 4As shown, when performing thrombectomy using the thrombectomy device 100 in this embodiment, the push-pull guide wire 10 is connected to the stent 20. The connected push-pull guide wire 10 and stent 20 are pressed into the microcatheter 330, and the stent 20 is in a compressed state under the action of the microcatheter 330. The thrombectomy device 100 reaches the thrombus 500 from the proximal end through the blood vessel 400 via minimally invasive surgery and the push-pull guide wire 10, and passes through the thrombus 500 from the proximal end of the thrombus 500. Under the observation of imaging devices such as CT and / or MRA, DSA, the distance between the first imaging marker 340 of the microcatheter 430 and the thrombus 500 is 5-40 mm. Fix the push-pull guide wire 10, withdraw the microcatheter 330 to the outside of the body, and check the first imaging marker 340 under the monitoring of the imaging device to know the path of the microcatheter 330 withdrawn in the body. Due to the withdrawal of the microcatheter 330, the compressed stent 20 is pushed out of the microcatheter 330 and returns to the expanded state. The expanded stent 20 and the thrombus 500 are pressed against each other, and the thrombus 500 enters or is clamped into the lumen of the capture section 22 through the openings (including the openings between the capture members) on the cylindrical structure of the capture section 22. After fixing the push-pull guide wire 10 for a period of time, the stent 20 is allowed to expand sufficiently to fix the thrombus 500. Under the pulling of the push-pull guide wire 10, the stent 20 moves towards the proximal end, and the stent 20 drives the thrombus 500 to move towards the proximal end together. When the push-pull guide wire 10 drives the stent 20 to retract to the second imaging marker 610 of the retrieval catheter 600, and the push-pull guide wire 10 continues to retract, the stent 20 and the captured thrombus 4500 are pulled into the retrieval catheter 600, and then the retrieval catheter 600 and the thrombectomy device 100 and the thrombus 500 in the retrieval catheter 600 are withdrawn as a whole to the outside of the patient's body, thus completing the entire thrombectomy process.

[0069] Embodiment 2

[0070] Combined with Figure 11 and Figure 12 As shown, the thrombectomy device 100 of this embodiment is basically the same as that of Embodiment 1, including a support section 21, a capture section 22, and a leak-proof section 23. The difference is that the capture section 22 of this embodiment includes two capture components 221, and the structure of any one of the capture components 221 is the same as that of the capture component in Embodiment 1.

[0071] Combined with Figure 12 and Figure 13 In the deployed structure, two adjacent capture members 222 of the two capture components 221 are arranged side by side in a direction perpendicular to the length direction of the deployed structure, so that at least two capture members 222 are provided on at least one cross-section of the cylindrical structure of the formed capture section 22. The length direction of the deployed structure is the first straight direction Z1.

[0072] It should be noted that the side-by-side arrangement of the capture members 222 here means that the entire capture members 222 in one capture component 221 and the entire capture members 222 in an adjacent capture component 221 are at least partially on the same straight line in a direction perpendicular to the length direction of the deployed structure. During the process of spiraling from the deployed structure into a cylindrical structure, multiple capture members 222 can be arranged on at least one cross-section of the cylindrical structure of the capture section 22. In other embodiments, the number of capture components 221 can also be multiple.

[0073] Here, "two adjacent capture members 222 in two capture components 221" includes two cases: First, the two capture components 221 are two adjacent capture components 221; Second, the two capture components 221 are two non-adjacent capture components 221. In this case, the two adjacent capture members 222 in the two capture components 221 can be considered as the two capture members 222 with the closest distance in the two capture components 221.

[0074] Refer to Figure 13 , when the stent 20 is in the natural state, the two capture components 221 are arranged at an interval of 180° in the circumferential direction of the capture section 22. Refer to Figure 12 , when in the deployed state, the multiple capture members 222 in any one capture component 221 are distributed in a gradient along the included angle d. The two capture components 221 are arranged in parallel, and the distance between the two capture components 221 is L5. The value of L5 is approximately half of the circumferential length of the capture section 22 of the cylindrical structure, so that the two capture components 221 under the cylindrical structure are arranged at an interval of 180° in the circumferential direction of the capture section 22. Among them, the distance between two adjacent capture members 222 in any one capture component 221 is L3 in the axial direction Z2 of the stent, and the distance is L4 in the direction perpendicular to the axial direction Z2 of the stent.

[0075] Compared with the capture section 22 including only one capture component 221 in the first embodiment, the capture section 22 of this embodiment is provided with two capture components 221, correspondingly reducing the mesh area on the cylindrical structure of the capture section 22, thereby improving the radial support force of the capture section 22, making it easier for the thrombus 500 to be captured by the stent 20, and the thrombus 500 is not easy to escape.

[0076] Embodiment Three

[0077] Combined with Figure 14 and Figure 15 As shown in, the thrombus extraction device 100 of this embodiment is basically the same as that of the second embodiment, including a support section 21, a capture section 22, and a leak prevention section 23. The capture section 22 includes two capture components 221. When the stent 20 is in the deployed state, the multiple capture members 222 in any one capture component 221 are distributed in a gradient along the included angle d, and the two capture components 221 are arranged in parallel.

[0078] The difference is that when the stent 20 of this embodiment is in the deployed state, the distance between the two capture components 221 is L8. The preferred value range of L8 is about 1 / 3 to 1 / 4 of the circumferential length of the capture section 22 of the cylindrical structure, so that the two sets of capture components 221 on the capture section 22 of the cylindrical structure are arranged at an interval of 90° to 120° in the circumferential direction of the capture section 22.

[0079] Combined with Figure 15 and Figure 16 As shown, in the deployed structure, two adjacent capture elements 222 in the two capture components 221 are arranged at intervals in the length direction of the deployed structure, so that in the formed cylindrical structure, the two adjacent capture elements are located on different cross-sections of the cylindrical structure. The length direction of the deployed structure is the first straight line direction Z1.

[0080] It should be noted that the spaced arrangement of the capture elements 222 here means that the capture elements 222 as a whole in one capture component 221 and the capture elements 222 as a whole in an adjacent capture component 221 are not on the same straight line perpendicular to the length direction of the deployed structure. During the process of spiraling from the deployed structure into a cylindrical structure, the capture elements 222 between the capture components 221 are completely staggered, and there will be no intersection or superposition between the capture elements 222 on the same cross-section, so that the radial dimension of the stent 20 in the contracted state is smaller, facilitating entry into a smaller microcatheter.

[0081] "Two adjacent capture elements 222 in the two capture components 221" here includes two cases: First, the two capture components 221 are two adjacent capture components 221; Second, the two capture components 221 are two non-adjacent capture components 221. At this time, the two adjacent capture elements 222 in the two capture components 221 can be considered as the two capture elements 222 with the closest distance in the two capture components 221.

[0082] In this embodiment, the capture section 22 is further provided with a grid structure 227. In the deployed structure, in the direction perpendicular to the length direction of the deployed structure, the grid structure 227 is arranged side by side with the capture component 221; or / and, the capture element 222 is arranged in the grid structure 227. Among them, the average mesh area of the grid structure 227 is larger than the opening size between adjacent capture elements 222 in the same capture component 221. The grid structure 227 with a larger mesh area can capture thrombus more easily, so that the thrombus with higher hardness can pass through the grid structure 227 into the lumen of the capture section 22, so as to collect the thrombus 500 more comprehensively, and finally completely remove the thrombus 500 in the blood vessel 400.

[0083] In this embodiment, in the capture section 22, all the capture elements 222 on all the capture components 221 are arranged in a spiral shape along the axial direction of the capture section 22, thereby forming a spiral structure on the capture section 22. In other embodiments, it may also be that the capture elements 222 on the same capture component 221 are arranged in a spiral shape along the axial direction of the capture section 22, and multiple capture components 221 form multiple spiral structures on the capture section 22.

[0084] Specifically, in this embodiment, the bracket 20 is integrally in the shape of a bracket cylinder. After the bracket cylinder structure is unfolded and flattened, it forms a bracket unfolded structure. The bracket unfolded structure can be spirally formed into a bracket cylinder structure around the axial direction of the bracket. The length direction of the bracket unfolded structure is arranged at an angle to the axial direction of the bracket cylinder structure. Specifically speaking, in addition to the capture section 22 having a spiral shape, the support section 21 and the leak-proof section 23 also have spiral shapes, that is, the bracket 20 as a whole has a spiral shape. After the bracket 20 is unwound and unfolded and flattened, in the unfolded structure, the length directions of the support section 21, the capture section 22, and the leak-proof section 23 are located on the same straight line, and this straight line is arranged at an angle to the axial direction of the bracket cylinder structure.

[0085] In this embodiment, after the support section 21, the capture section 22, and the leak-proof section 23 are integrally spirally formed into a cylindrical structure, heat setting treatment can be performed to maintain the overall shape; or they can be connected and fixed by internal connecting rods to maintain the overall shape. When it needs to be unfolded, the internal connecting rods can be directly cut off to form an unfolded structure. The bracket 20 can be integrally formed by cutting a pipe body, or the support section 21, the capture section 22, and the leak-proof section 23 can be formed separately and then connected together by welding or other means.

[0086] The above is only a preferred specific embodiment of the present invention, but the protection scope of the present invention is not limited thereto. Any changes or substitutions that can be easily thought of by those skilled in the art within the technical scope disclosed by the present invention should be covered within the protection scope of the present invention. Therefore, the protection scope of the present invention should be subject to the protection scope of the claims.

Claims

1. A thrombectomy device, characterized in that, Comprising: Push-pull guide wire; A stent, the stent is connected to the push-pull guide wire, the stent includes a capture section, the capture section is integrally in a cylindrical structure, the cylindrical structure is unfolded and flattened to form the unfolded structure of the capture section, and the unfolded structure can be spirally formed into the cylindrical structure around the axial direction of the capture section. At least one capture component is provided on the capture section. The capture component includes a plurality of capture elements, and the plurality of capture elements are sequentially arranged in a spiral shape along the axial direction of the capture section in the cylindrical structure. The capture element includes a first stent rod and a second stent rod. The ends of the first stent rod and the second stent rod away from the push-pull guide wire converge at a point to form a free end, and any one of the capture elements is arranged in a spiral shape along the axial direction of the capture section.

2. The thrombectomy device according to claim 1, wherein, In the unfolded structure of the capture section, the plurality of capture elements of the same capture component are sequentially arranged along a first straight line direction, and the first straight line direction is arranged at an angle with the axial direction of the stent.

3. The thrombectomy device according to claim 1, characterized in that, In the capture section, all the capture elements are arranged in a spiral shape along the axial direction of the capture section.

4. The thrombectomy device according to claim 1, wherein, The number of the capture components is multiple. In the unfolded structure, two adjacent capture components are arranged parallel to each other.

5. The thrombus extraction device according to claim 4, wherein In the unfolded structure, two adjacent capture elements of the two capture components are arranged side by side in a direction perpendicular to the length direction of the unfolded structure, so that there are at least two capture elements on at least one cross section of the formed cylindrical structure.

6. The thrombectomy device according to claim 4, wherein, In the unfolded structure, two adjacent capture elements of the two capture components are arranged at intervals in the length direction of the unfolded structure, so that in the formed cylindrical structure, the two adjacent capture elements are located on different cross sections of the cylindrical structure.

7. The thrombectomy device according to claim 1, wherein The stent is further provided with a grid structure. In the unfolded structure, In a direction perpendicular to the length direction in the unfolded structure, the grid structure is arranged side by side with the capture component; or / and, the capture element is arranged in the grid structure.

8. The thrombectomy device according to claim 1, wherein, The stent further includes a support section or / and an anti-detachment section. The support section, the capture section and the anti-detachment section are sequentially connected along the axial direction of the stent, and the push-pull guide wire is connected to the proximal end of the stent.

9. The thrombectomy device according to claim 1, wherein, The stent is integrally in a stent cylindrical structure. The stent cylindrical structure is unfolded and flattened to form a stent unfolded structure, and the stent unfolded structure can be spirally formed into the stent cylindrical structure around the axial direction of the stent. The length direction of the stent unfolded structure is arranged at an angle with the axial direction of the stent cylindrical structure.

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