Fully enclosed high-precision flow splitting device and fully enclosed high-precision flow splitting method

Abstract

The present invention discloses a fully enclosed high-precision flow splitting device, which includes a flow splitting device and a flow splitting container; the flow splitting device includes a housing and a partition; the two ends of the housing are provided with a liquid inlet and a liquid outlet; the partition is fixed inside the housing and divides the internal space of the housing into a plurality of flow guiding layers with the same shape and size; the number of flow guiding layers is the same as that of the liquid outlets, and one flow guiding layer is communicated with one liquid outlet; the housing is provided with communication holes and ventilation holes communicated with each flow guiding layer; the communication holes are used to convey the solution input from the liquid inlet into each flow guiding layer; the ventilation holes are used to make the air pressure of each flow guiding layer consistent; the number of flow splitting containers is the same as that of the liquid outlets, and the two correspond to each other one by one; each flow splitting container is respectively communicated with the corresponding liquid outlet through different connecting pipes. In the above device, the flow splitting device can evenly divide one portion of the solution into multiple portions, with high efficiency and being convenient for realizing large-scale coating production. The present invention also provides a fully enclosed high-precision flow splitting method.

Description

Technical Field

[0001] The present invention relates to the technical field of cell culture, and more specifically, to a fully enclosed high-precision shunting device and a fully enclosed high-precision shunting method. Background Art

[0002] During the cell culture process, a coating solution needs to be injected into a shunting container (such as a culture flask or a culture plate), shaken well and left standing so that part of the coating solution can adhere to the inner wall of the shunting container, and then the excess coating solution is poured out, leaving only the coating coupling layer adhering to the inner wall of the shunting container.

[0003] Currently, in practical applications, the coating of shunting containers is usually mainly manual. However, the efficiency of manual dispensing of the coating solution is low, and it is only suitable for coating a small number of shunting containers, and it is impossible to achieve large-scale coating production.

[0004] In addition, the method of manual dispensing of the coating solution needs to be carried out in a Class A aseptic environment, and an additional aseptic room needs to be set up, resulting in increased costs.

[0005] Furthermore, the accuracy of manual dispensing of the coating solution is low, which inevitably causes too much expensive coating solution in the shunting container, and the excess coating solution needs to be poured out in subsequent operation steps, resulting in waste.

[0006] In summary, how to avoid manually dispensing the coating solution for coating shunting containers in a Class A aseptic environment, improve the efficiency, and thus achieve large-scale coating production is an urgent problem to be solved by those skilled in the art. Summary of the Invention

[0007] In view of this, the present invention provides a fully enclosed high-precision shunting device, which can accurately divide a portion of the solution to be shunted into multiple portions by means of a shunting device. Compared with the method of manually dispensing the solution, the efficiency is greatly improved, the accuracy is also improved, and it is suitable for coating a large number of shunting containers, facilitating large-scale coating production. The present invention also provides a fully enclosed high-precision shunting method for the above-mentioned fully enclosed high-precision shunting device, which has a high dispensing efficiency for the solution, improves the dispensing accuracy, and is convenient for realizing large-scale coating production.

[0008] To achieve the above object, the present invention provides the following technical solutions:

[0009] A fully enclosed high-precision shunting device includes a shunting device and a shunting container; the shunting device includes:

[0010] A housing provided with a liquid inlet and a liquid outlet, and the liquid inlet and the liquid outlet are located at both ends of the housing;

[0011] A partition board, fixed inside the housing and dividing the internal space of the housing into a plurality of identical diversion layers; the number of the diversion layers is the same as the number of the liquid outlet ports, and one of the diversion layers is communicated with one of the liquid outlet ports;

[0012] Wherein, the housing is provided with a communication hole and a ventilation hole; the communication hole is communicated with each of the diversion layers and is used for conveying the solution to be divided input from the liquid inlet port into each of the diversion layers; the ventilation hole is communicated with each of the diversion layers for making the air pressure of each of the diversion layers consistent; the communication hole and the ventilation hole are separated from each other;

[0013] The number of the shunt containers is the same as the number of the liquid outlet ports, and the two are in one-to-one correspondence; each of the shunt containers is respectively connected to the corresponding liquid outlet port through a different connecting pipe.

[0014] Preferably, in the above-mentioned fully enclosed high-precision shunt device, the shunt device has a filling state and a liquid dividing state. In the filling state, the liquid inlet port is located at the lower end of the housing, and the liquid outlet port is located at the upper end of the housing; in the liquid dividing state, the liquid inlet port is located at the upper end of the housing, and the liquid outlet port is located at the lower end of the housing.

[0015] Preferably, in the above-mentioned fully enclosed high-precision shunt device, the ventilation hole is located at the end of the housing provided with the liquid inlet port.

[0016] Preferably, in the above-mentioned fully enclosed high-precision shunt device, the diversion layer is divided into a main body part and a ventilation channel part by a partition bar; the main body part is communicated with the communication hole; one end of the ventilation channel part is communicated with the main body part, and the other end of the ventilation channel part is communicated with the ventilation hole.

[0017] Preferably, in the above-mentioned fully enclosed high-precision shunt device, the main body part includes a buffer part and a guiding part, the buffer part is communicated with the liquid inlet port through the communication hole, and the guiding part is communicated with the liquid outlet port.

[0018] Preferably, in the above-mentioned fully enclosed high-precision shunt device, the buffer part and the guiding part are communicated with each other.

[0019] Preferably, in the above-mentioned fully enclosed high-precision shunt device, the buffer part and the guiding part are communicated through a communication port; in the direction of the liquid inlet port towards the communication port, the cross-sectional area of the buffer part gradually becomes smaller; among all the cross-sections in the direction of the liquid inlet port towards the liquid outlet port, the cross-sectional area of the communication port is the smallest.

[0020] Preferably, in the above-mentioned fully enclosed high-precision flow splitting device, the buffer part and the guiding part are communicated through a communication port; in the direction of the liquid inlet towards the communication port, the cross-sectional area of the buffer part remains unchanged.

[0021] A fully enclosed high-precision flow splitting method, which is used for the fully enclosed high-precision flow splitting device described in any one of the above technical solutions, includes:

[0022] Input the solution to be split from the liquid inlet into the flow splitting device. The solution to be split is split into each diversion layer through the communication holes, and is evenly distributed to each diversion layer under the pressure equalizing action of the ventilation holes; the liquid inlet is located at the lower end of the liquid outlet.

[0023] Rotate the outer shell until the liquid inlet is located at the upper end of the liquid outlet.

[0024] Open each liquid outlet, so that each portion of the evenly distributed solution to be split flows out through the connecting pipe to the flow splitting containers corresponding to each liquid outlet one by one.

[0025] Preferably, in the above-mentioned fully enclosed high-precision flow splitting method, before rotating the outer shell until the liquid inlet is located at the upper end of the liquid outlet, it includes:

[0026] After the solution to be split finishes flowing in, rotate the outer shell to make the evenly distributed solution to be split flow from the buffer part along the direction away from the communication hole to the guiding part.

[0027] Preferably, in the above-mentioned fully enclosed high-precision flow splitting method, after each portion of the evenly distributed solution to be split flows out through the connecting pipe to the flow splitting containers corresponding to each liquid outlet one by one, it includes:

[0028] Shake the flow splitting containers to make the solution in each flow splitting container fit the inner wall of the flow splitting container.

[0029] Flip the flow splitting containers and the outer shell, so that the excess solution in the flow splitting containers flows back to the diversion layer through the connecting pipe, and then is recovered through the liquid inlet.

[0030] The present invention provides a fully enclosed high-precision flow splitting device, which includes a flow splitting device and a flow splitting container; the flow splitting device includes a housing and a partition; the housing is provided with a liquid inlet and a liquid outlet, and the liquid inlet and the liquid outlet are located at both ends of the housing; the partition is fixed inside the housing and divides the internal space of the housing into a plurality of diversion layers with the same shape and size; the number of diversion layers is the same as the number of liquid outlets, and one diversion layer is respectively communicated with one liquid outlet; wherein, the housing is provided with a communication hole and a ventilation hole; the communication hole is communicated with each diversion layer and is used for conveying the solution to be evenly divided input from the liquid inlet into each diversion layer; the ventilation hole is communicated with each diversion layer and is used to make the air pressure of each diversion layer consistent; the communication hole and the ventilation hole are separated from each other; the number of flow splitting containers is the same as the number of liquid outlets, and the two correspond one by one; each flow splitting container is respectively connected to its corresponding liquid outlet through a different connecting pipe.

[0031] In the above-mentioned fully enclosed high-precision flow splitting device, the flow splitting device can evenly divide a portion of the solution to be split into multiple portions. Compared with the method of manually dispensing the coating solution, the efficiency is higher, which is suitable for large-scale coating of flow splitting containers and is convenient for realizing large-scale coating production.

[0032] At the same time, in the above-mentioned fully enclosed high-precision flow splitting device, the flow splitting container is communicated with the liquid outlet of the flow splitting device through a connecting pipe to form a closed channel, so there is no need to dispense the solution in a sterile environment, avoiding the need to additionally set up a sterile room during cell culture production and preventing the cost from increasing.

[0033] Furthermore, in the above-mentioned fully enclosed high-precision flow splitting device, the liquid splitting accuracy of the flow splitting device is high, which can ensure that each portion of the split solution is uniform. By adding an appropriate amount of solution to the liquid inlet, an appropriate and equal amount of solution can be respectively input into each flow splitting container, avoiding waste caused by adding too much solution. At the same time, when in use, the solution input into each flow splitting container can be slightly excessive to improve the efficiency of shaking the flow splitting container to make the solution fit the inner wall of the flow splitting container, and the excessive solution can be recovered through the flow splitting device to avoid waste.

[0034] The present invention also provides a fully enclosed high-precision flow splitting method, which is used for the above-mentioned fully enclosed high-precision flow splitting device, and has a high dispensing efficiency for the solution, and is convenient for realizing large-scale coating production. BRIEF DESCRIPTION OF THE DRAWINGS

[0035] In order to more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the following will briefly introduce the drawings required to be used in the description of the embodiments or the prior art. Obviously, the following drawings are only some embodiments of the present invention. For those of ordinary skill in the art, without creative efforts, other drawings can be obtained based on these drawings.

[0036] Figure 1 It is a cross-sectional view of the flow splitting device provided by the embodiment of the present invention;

[0037] Figure 2 is Figure 1 a perspective view of the shown flow splitting device;

[0038] Figure 3 is Figure 1 a schematic structural view of the shown flow splitting device in the filling state;

[0039] Figure 4 is Figure 1 a schematic structural view of the shown flow splitting device during the process of switching from the filling state to the liquid splitting state;

[0040] Figure 5 is a perspective structural view of another flow splitting device provided by an embodiment of the present invention;

[0041] Figure 6 is Figure 5 a front view structural view of the shown flow splitting device;

[0042] Figure 7 is Figure 6 a sectional view taken along A - A in ;

[0043] Figure 8 is Figure 7 a schematic view of the main body part of the shown flow splitting device;

[0044] Figure 9 is Figure 5 another sectional view of the shown flow splitting device from a different angle;

[0045] Figure 10 is a schematic structural view of a fully enclosed high - precision flow splitting device provided by an embodiment of the present invention;

[0046] Among them, Figures 1 - 10 in:

[0047] flow splitting device 100; housing 101; liquid inlet 111; liquid outlet 112; communication hole 113; ventilation hole 114; diversion layer 102; main body part 121; guiding part 1211; buffer part 1212; liquid baffle 12121; bottom plate 12122; ventilation channel part 122; partition strip 123; flow splitting container 200; connecting pipe 300. Specific embodiments

[0048] An embodiment of the present invention discloses a fully enclosed high-precision shunting device, which can accurately divide a solution to be divided into multiple portions by using a shunting device. Compared with the method of manually filling solutions, the efficiency and accuracy are greatly improved. At the same time, it is applicable to the coating of a large number of shunting containers, facilitating the realization of large-scale coating production. An embodiment of the present invention also discloses a fully enclosed high-precision shunting method for the above-mentioned fully enclosed high-precision shunting device, which has a high filling efficiency for the solution to be divided, improves the filling accuracy, and is convenient for realizing large-scale coating production.

[0049] Next, the technical solutions in the embodiments of the present invention will be clearly and completely described with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present invention.

[0050] Please refer to Figures 1 - 10 , an embodiment of the present invention provides a fully enclosed high-precision shunting device, including a shunting device 100 and a shunting container 200; the shunting device 100 includes a housing 101 and a partition; the housing 101 is provided with a liquid inlet 111 and a liquid outlet 112, and the liquid inlet 111 and the liquid outlet 112 are located at opposite ends of the housing 101; the partition is fixed inside the housing 101 and divides the internal space of the housing 101 into a plurality of diversion layers 102 with the same shape and size; the number of the diversion layers 102 is the same as the number of the liquid outlets 112, and one diversion layer 102 is communicated with one liquid outlet 112, and the diversion layers 102 and the liquid outlets 112 are in one-to-one correspondence; wherein, the housing is provided with a communication hole 113 and a ventilation hole 114; the communication hole 113 is communicated with each diversion layer 102 and is used to convey the solution to be divided input from the liquid inlet 111 into each diversion layer 102; the ventilation hole 114 is communicated with each diversion layer 102 and is used to make the air pressure of each diversion layer 102 consistent; the number of the shunting containers 200 is the same as the number of the liquid outlets 112, and the two are in one-to-one correspondence; each shunting container 200 is respectively communicated with the corresponding liquid outlet 112 through a different connecting pipe 300.

[0051] The above-mentioned fully enclosed high-precision shunting device can be used for cell culture. Correspondingly, the solution to be divided is a coating solution.

[0052] In the fully enclosed high-precision shunting device provided in this embodiment, the housing 101 of the shunting device 100 is divided into a plurality of identical diversion layers 102 by a partition, and the diversion layers 102 communicate with each other through ventilation holes 114, so that the air pressure in each diversion layer 102 is the same, ensuring that the liquid levels in each diversion layer 102 are the same, and further ensuring that the volumes of the solutions entering each diversion layer 102 are the same, realizing the equal division of a portion of the solution to be divided into multiple portions. Compared with the method of manually dispensing the solution, the efficiency is higher, which is suitable for the coating of a large number of shunting containers 200, facilitating the realization of large-scale coating production.

[0053] In addition, in the above-mentioned fully enclosed high-precision shunting device, the shunting container 200 is connected to the liquid outlet 112 of the shunting device 100 through a connecting pipe 300 to form a closed channel, eliminating the need to dispense the solution in a sterile environment, avoiding the additional setting of a sterile room during cell culture production, and preventing the cost from increasing.

[0054] Furthermore, in the above-mentioned fully enclosed high-precision shunting device, the shunting device 100 has high liquid separation precision, which can ensure that each portion of the evenly divided solution is uniform. By adding an appropriate amount of the solution to be evenly divided to the liquid inlet 111, an appropriate and equal amount of solution can be respectively input into each shunting container 200, avoiding waste caused by adding too much solution. At the same time, when in use, the solution input into each shunting container 200 can be slightly excessive to improve the efficiency of shaking the shunting container 200 to make the solution adhere to the inner wall of the shunting container 200, and the excessive solution can be recovered through the shunting device 100 to avoid waste.

[0055] The above-mentioned shunting device 100 has a filling state and a liquid separation state. In the filling state, the liquid inlet 111 is located at the lower end of the housing 101, and the liquid outlet 112 is located at the upper end of the housing 101; in the liquid separation state, the liquid inlet 111 is located at the upper end of the housing 101, and the liquid outlet 112 is located at the lower end of the housing 101. During the application process, when switching the shunting device 100 from the filling state to the liquid separation state, the housing 101 can be rotated 180° in the vertical plane. Specifically, after the liquid inlet 111 is filled with liquid, the solution is concentrated in the space 1 of the diversion layer 102 as shown in Figure 8 Then, the housing 101 is rotated 180° in the vertical plane, and the solution in the space 1 flows to the space 2. The solution in the space 2 of each diversion layer 102 flows out of the liquid outlet 112 to each shunting container 200 under the action of gravity. During the whole process, the ventilation holes 114 will not come into contact with the solution. The communication holes 113 and ventilation holes 114 of each diversion layer 102 form an inverted "U" shape design. Through a partition strip 123, the main body part 121 and the ventilation channel part 122 are separated, and the partition strip 123 is higher than the liquid level in the case of the space 2 of the solution and higher than the liquid level oscillation height during the rotation process.

[0056] In the flow splitting device 100 provided in this embodiment, the inner space of the outer shell 101 is completely and evenly separated by a partition plate, and only the communication holes 113 and the ventilation holes 114 communicate with each flow guiding layer 102, and the shapes and sizes of each flow guiding layer 102 are ensured to be exactly the same. In the liquid separation state, the liquid inlet 111 of the outer shell 101 is placed at the bottom and the liquid outlet 112 is placed at the top, and it is fixed vertically. Then, the solution enters through the liquid inlet 111 and flows to each flow guiding layer 102 through the communication holes 113. The gases inside each flow guiding layer 102 communicate with each other through the ventilation holes 114, ensuring that the air pressures of each flow guiding layer 102 are the same, ensuring that the liquid levels of each flow guiding layer 102 are kept at the same horizontal plane under the action of gravity at this time. At the same time, the shapes and sizes of each flow guiding layer 102 are exactly the same, so that the volume of the solution in each flow guiding layer 102 is the same; then, the outer shell 101 is quickly rotated 180° in the vertical plane to switch to the liquid separation state, and the solution in the flow guiding layer 102 quickly flows from the direction of the liquid inlet 111 to the direction of the liquid outlet 112, and then flows out from the liquid outlet 112 to each flow splitting container 200 to achieve the average distribution of the solution. When more portions need to be evenly divided, only the corresponding number of flow guiding layers 102 needs to be added to meet the evenly dividing requirements of more portions.

[0057] In the above-mentioned flow splitting device 100, the ventilation hole 114 is located at the end of the outer shell 101 where the liquid inlet 111 is arranged. Specifically, the flow guiding layer 102 of the above-mentioned flow splitting device 100 is divided into a main body part 121 and a ventilation channel part 122 by a partition strip 123; the main body part 121 communicates with the communication hole 113; one end of the ventilation channel part 122 communicates with the main body part 121, and the other end of the ventilation channel part 122 communicates with the ventilation hole 114.

[0058] In the flow splitting device 100 provided in this embodiment, the setting method of the ventilation hole 114 can not only ensure the air pressure balance of each flow guiding layer 102, but also ensure that the solutions in different flow guiding layers 102 do not communicate with each other through the ventilation hole 114 when the outer shell 101 rotates to discharge liquid during the state switching, ensuring the uniformity of the solutions in each flow guiding layer 102 and further improving the even distribution effect.

[0059] Specifically, in the above-mentioned flow splitting device 100, the ventilation hole 114 is close to the liquid inlet 111. The cross-section of the communication hole 113 is square, with a size of 8 mm × 8 mm, and is used to quickly flow the solution to each flow guiding layer 102. Each ventilation channel part 122 is a square column, with a size of 8 mm × 8 mm.

[0060] Please refer to FIGS. 1, 3, and 4. In the above-mentioned flow splitting device 100, the main body portion 121 includes a buffer portion 1212 and a guiding portion 1211. The buffer portion 1212 is communicated with the liquid inlet 111 through a communication hole 113, and the guiding portion 1211 is communicated with the liquid outlet 112. The buffer portion 1212 and the guiding portion 1211 are communicated with each other. The buffer portion 1212 is used to temporarily store all or part of the solution that has been poured into the diversion layer 102 first when the flow splitting device 100 switches from the filling state to the liquid splitting state, and then convey the buffered solution to the guiding portion 1211.

[0061] The design of the buffer portion 1212 is particularly beneficial for ensuring accurate equal distribution of small-volume solutions, reducing the error to an extremely low level. Specifically, as Figure 1 shown, the buffer portion 1212 is a semi-open small container composed of a liquid baffle 12121 and a bottom plate 12122. The capacity of this small container is 3 / 4 of the total amount of small-volume solutions equally divided by the flow splitting device 100. When the outer shell 101 rotates counterclockwise vertically by 90°, the solution first flows entirely into the small container, and the solutions in each diversion layer 102 are disconnected from the communication hole 113. At this time, the total volume of the solution has been evenly distributed into each diversion layer 102 within the outer shell 101, as Figure 4 shown. After that, the outer shell 101 rotates counterclockwise by another 90°, and the solution flows out from the liquid outlet 112 into the flow splitting container 200, achieving equal distribution of the solution. The distal end of the liquid baffle 12121 (i.e., the end far from the liquid inlet 111 and also the end connected to the bottom plate 12122) gradually approaches the liquid inlet 111 from the bottom to the top, as Figure 3 shown.

[0062] In the flow splitting device provided in this embodiment, the structural design of the buffer portion 1212 (as Figure 3 shown) can reduce the surface area of the liquid in the container in space 1. Because the surface area is small enough, the surface tension during rotation is small enough, ensuring that the capacity deviation of each diversion layer 102 is small, so that the capacities of each diversion layer 102 can achieve high-precision consistency. The overall structural design of space 1 is to achieve small-space splitting of small-capacity solutions and large-space splitting of large-capacity solutions.

[0063] The buffer portion 1212 and the guiding portion 1211 are communicated through a communication port; in the direction of the liquid inlet 111 towards the communication port, the cross-sectional area of the buffer portion 1212 gradually becomes smaller; among all the cross-sections in the direction of the liquid inlet 111 towards the liquid outlet 112, the cross-sectional area of the communication port is the smallest, as Figure 3 、 4 shown. Or, the buffer portion 1212 and the guiding portion 1211 are communicated through a communication port; in the direction of the liquid inlet 111 towards the communication port, the cross-sectional area of the buffer portion 1212 remains unchanged, as Figure 7 、8 as shown

[0064] All cross-sections in the direction of the liquid inlet 111 facing the liquid outlet 112 include the cross-sections of the buffer part 1212 and the guiding part 1211; the smaller the cross-sectional area of the communication port, the higher the accuracy of the solution to be divided equally in each diversion layer 102.

[0065] Specifically, in the above-mentioned shunt device 100, there are multiple partition plates, and the partition plates are arranged in parallel. The number of partition plates is 1 less than the number of diversion layers 102. There is one liquid inlet 111, and the number of liquid outlets 112 is the same as the number of diversion layers 102.

[0066] In the solution provided in this embodiment, the shunt device 100 can rotate to make the solution in the space 1 of the diversion layer 102 flow to the space 2, ensuring that the liquid volume flowing out to each shunt container 200 meets the high-precision requirements, and the accuracy reaches 0.3 ml.

[0067] The embodiment of the present invention also provides a fully enclosed high-precision shunting method for the fully enclosed high-precision shunting equipment provided in the above embodiment, including:

[0068] Input the solution to be divided into the shunt device 100 from the liquid inlet 111. The solution to be divided is shunted to each diversion layer 102 through the communication holes 113 and evenly distributed to each diversion layer 102 under the pressure equalization of the ventilation holes 114; the liquid inlet 111 is located at the lower end of the liquid outlet 112; after the input of the solution to be divided is completed, close the liquid inlet 111;

[0069] Rotate the outer shell 101 until the liquid inlet 111 is located at the upper end of the liquid outlet 112;

[0070] Open each liquid outlet 112, so that each portion of the evenly divided solution to be divided flows out through the communication pipe to the shunt container 200 corresponding to each liquid outlet 112 one by one.

[0071] Before performing the above step "rotate the outer shell 101 until the liquid inlet 111 is located at the upper end of the liquid outlet 112", rotate the outer shell 101 to make the evenly divided solution to be divided flow from the buffer part 1212 in the outer shell 101 to the guiding part 1211.

[0072] The above-mentioned rotation of the outer shell 101 to make the evenly divided solution to be divided flow from the buffer part 1212 in the outer shell 101 to the guiding part 1211 includes: after the inlet of the solution to be divided is completed, rotate the outer shell 101 to make the evenly divided solution to be divided flow from the buffer part 1212 along the direction away from the communication hole 113 to the guiding part 1211.

[0073] After the above-mentioned step of making each portion of the evenly divided solution to be divided flow out through the communication pipe to the shunt container 200 corresponding to each liquid outlet 112 one by one includes:

[0074] Shake the shunt container 200 so that the solution in each shunt container 200 adheres to the inner wall of the shunt container 200;

[0075] Flip the shunt container 200 and the outer shell 101 so that the excess solution in the shunt container 200 flows back to the diversion layer 102 through the communication pipe and is then recycled through the liquid inlet 111; specifically, after flipping the shunt container 200 and the outer shell 101, the shunt container 200 is located above the outer shell 101, and the liquid outlet 112 of the outer shell 101 is located above the liquid inlet 111. The excess solution in the shunt container 200 flows back to the diversion layer 102 through the communication pipe and the liquid outlet 112 under the action of its own gravity, and then flows to the liquid inlet 111 and is discharged, which is convenient for collecting and recycling the excess solution from the liquid inlet 111.

[0076] This embodiment provides a fully enclosed high-precision shunting method for the equipment provided in the above embodiment, which has a high liquid dispensing efficiency and is convenient for realizing large-scale coating production.

[0077] Of course, the fully enclosed high-precision shunting method provided in this embodiment also has other effects of the method provided in the above embodiment, which will not be elaborated here.

[0078] The following introduces the experimental situation of equalizing the shunting device 100 provided in the above embodiment:

[0079] According to the above liquid separation steps, prepare 50 shunt containers 200, first weigh them separately, use a 1-to-50 shunting device 100, with a total water inlet of 0.5 L, evenly divide it into 50 portions, each portion being 0.01 L. Complete the equalization of the liquid according to the steps to obtain shunt containers 200 filled with the equalized liquid. Weigh these 50 shunt containers 200 filled with the equalized liquid respectively, and then subtract the weight of the empty shunt container 200 to convert and obtain the actual volume of the liquid separated by each diversion layer 102. Then calculate how much each shunt container 200 differs from the theoretical value of 0.01 L. Repeat 10 times to obtain a series of error values. The shunt container 200 can be a culture flask.

[0080] The test results of the culture flasks after shunting by the shunt in the prior art control group are as follows:

[0081]

[0082]

[0083]

[0084] The test results of the culture flasks after shunting by the shunting device 100 of the present application are as follows:

[0085]

[0086]

[0087]

[0088] The test results show that after the prior art control group shunt divides 5L into 50 portions, the consistency error of the liquid inlet volume of the tested T225 bottles is 6.6 mL; while the consistency error of the shunt device 100 of the present application after dividing 5L into 50 portions is 0.4 mL; the consistency error is optimized by 93.9%.

[0089] The structure of the liquid baffle 12121 in the shunt device 100 provided in this embodiment is an innovative design, which effectively reduces the liquid surface area in the shunt state of the existing liquid divider. In addition, it also avoids the problem of liquid surging in the outer shell 101, providing feasibility for efficiently and in large quantities evenly dividing the number of liquid portions, and can control the consistency error of evenly dividing the liquid within 0.5 mL + 2%V mL.

[0090] The various embodiments in this specification are described in a progressive manner. Each embodiment focuses on the differences from other embodiments. For the same and similar parts between the various embodiments, reference can be made to each other.

[0091] The above description of the disclosed embodiments enables those skilled in the art to implement or use the present invention. Various modifications to these embodiments will be obvious to those skilled in the art. The general principles defined herein can be implemented in other embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention will not be limited to these embodiments shown herein, but rather to the broadest scope consistent with the principles and novel features disclosed herein.

Claims

1. A fully enclosed high-precision flow splitting device, characterized in that, It includes a flow splitting device and a flow splitting container; The flow splitting device includes: A housing provided with a liquid inlet and a liquid outlet, and the liquid inlet and the liquid outlet are located at both ends of the housing; A partition plate fixed inside the housing and dividing the internal space of the housing into a plurality of identical flow guiding layers; the number of the flow guiding layers is the same as the number of the liquid outlets, and one flow guiding layer is communicated with one liquid outlet; Wherein, the housing is provided with a communication hole and a ventilation hole; the communication hole is communicated with each flow guiding layer and is used for conveying the solution to be split input from the liquid inlet into each flow guiding layer; the ventilation hole is communicated with each flow guiding layer and is used for making the air pressure of each flow guiding layer consistent; the communication hole and the ventilation hole are separated from each other; The number of the flow splitting containers is the same as the number of the liquid outlets, and they correspond to each other one by one; each flow splitting container is respectively connected to the corresponding liquid outlet through a different connecting pipe; The ventilation hole is located at the end of the housing where the liquid inlet is provided; The flow guiding layer is divided into a main body part and a ventilation channel part by a partition bar; the main body part is communicated with the communication hole; one end of the ventilation channel part is communicated with the main body part, and the other end of the ventilation channel part is communicated with the ventilation hole; The main body part includes a buffer part and a guiding part, the buffer part is communicated with the liquid inlet through the communication hole, and the guiding part is communicated with the liquid outlet.

2. The fully enclosed high-precision flow splitting device according to claim 1, wherein The flow splitting device has a filling state and a liquid splitting state. In the filling state, the liquid inlet is located at the lower end of the housing and the liquid outlet is located at the upper end of the housing; in the liquid splitting state, the liquid inlet is located at the upper end of the housing and the liquid outlet is located at the lower end of the housing.

3. The fully enclosed high-precision flow splitting device according to claim 1, wherein, The buffer part and the guiding part are communicated with each other.

4. The fully enclosed high-precision flow splitting device according to claim 3, characterized in that, The buffer part and the guiding part are communicated through a communication port; in the direction of the liquid inlet towards the communication port, the cross-sectional area of the buffer part gradually becomes smaller; among all the cross-sections in the direction of the liquid inlet towards the liquid outlet, the cross-sectional area of the communication port is the smallest.

5. The fully enclosed high-precision flow splitting device according to claim 3, wherein The buffer part and the guiding part are communicated through a communication port; in the direction of the liquid inlet towards the communication port, the cross-sectional area of the buffer part remains unchanged.

6. A fully enclosed high-precision flow splitting method, for the fully enclosed high-precision flow splitting device according to any one of claims 1-5, characterized in that, It includes: Input the solution to be split from the liquid inlet into the flow splitting device. The solution to be split is split into each flow guiding layer through the communication hole and is evenly distributed to each flow guiding layer under the pressure equalizing action of the ventilation hole; the liquid inlet is located at the lower end of the liquid outlet; Rotate the housing so that the liquid inlet is located at the upper end of the liquid outlet; Open each liquid outlet so that each portion of the evenly divided solution to be split flows out through the connecting pipe to the flow splitting container corresponding to each liquid outlet.

7. The fully enclosed high-precision flow splitting method according to claim 6, characterized in that, Before rotating the housing so that the liquid inlet is located at the upper end of the liquid outlet, it includes: After the solution to be split is filled, rotate the housing to make the evenly divided solution to be split flow from the buffer part along the direction away from the communication hole to the guiding part.

8. The fully enclosed high-precision flow splitting method according to claim 6, wherein After making each portion of the evenly divided solution to be split flow out through the connecting pipe to the flow splitting container corresponding to each liquid outlet, it includes: Shake the shunt container so that the solution in each shunt container adheres to the inner wall of the shunt container; Flip the shunt container and the housing so that the excess solution in the shunt container flows back to the diversion layer through the connecting pipe and is then recovered through the liquid inlet.

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