Ion guide rod and detection device

Abstract

The present invention discloses an ion guide rod and a detection device, wherein the ion guide rod comprises: a support column; and a tip tube, which is arranged on the support column; wherein an adjustment tube is arranged between the support column and the tip tube, the adjustment tube is sleeved on the outer circumference of the support column, and different adjustment tubes have different lengths. According to the present invention, it is possible to strictly ensure the axial spacing between the ion guide rod and the interceptor cone with an accuracy of 0.1mm, eliminating the error caused by the assembly dimension chain. The performance of the mass spectrometer is structurally optimized, and the inter-unit differences in the production and assembly process are reduced. At the same time, it is possible to complete the length adjustment of the ion guide rod in the vacuum chamber without removing the ion optical guide rail, greatly simplifying the adjustment process and improving the assembly efficiency.

Description

Technical Field

[0001] The present invention relates to the field of mass analysis instruments, and more particularly to an ion guide rod and a detection device. Background Art

[0002] A mass spectrometer consists of an inlet system, ion source, vacuum system, mass analyzer, detector, and data acquisition system. Triple quadrupole mass spectrometers, with their comprehensive performance, are widely used in medicine, environmental protection, food safety, clinical research, and forensics. Their inlet system and ion source are located at atmospheric pressure, while the mass analyzer and detector are housed in a vacuum system. After ionization by the ion source, the sample enters the vacuum chamber through an interface cone. A commonly used three-cone configuration is the curtain cone, the pinhole cone, and the skimmer cone. Heated nitrogen gas, called the curtain gas, flows between the curtain cone and the pinhole cone, further evaporating the solvent from the sample droplets. The pinhole cone is used for ion sampling and differential vacuum. When the ion stream enters the first vacuum stage from atmospheric pressure, the rapid pressure change causes supersonic jet expansion. The skimmer cone partially intercepts and dissipates the heat from the expanding ion stream, further creating a differential vacuum. After passing through the skimmer cone, the ions enter the quadrupole guide region. The quadrupole field generated by the ion guide rod assembly causes the ion stream to oscillate and gradually guide it into the mass analyzer.

[0003] The existing structure is to assemble the ion guide rod, the first quadrupole, the collision cell, and the third quadrupole on the ion optical rail. The ion optical rail is connected to the vacuum chamber at the rear end by a thread, and the interface cone is fixed at the front end of the vacuum chamber. This structure has a problem. The positioning dimension chain of the ion guide rod is long, and its axial position is affected by the processing accuracy of many parts, making it difficult to control. If the ion guide rod is axially positioned closer to the skimmer cone, then the ion guide rod will intervene earlier during the expansion of the ion flow and guide more ions. However, the front end of the ion guide rod will be subjected to more expansion shock waves, and there is a risk of discharge with the skimmer cone. If the ion guide rod is axially positioned further away from the skimmer cone, more ions will diffuse into the chamber and not be guided by the ion guide rod, reducing the detection capability of the mass spectrometer.

[0004] In view of this, it is necessary to develop an ion guide rod and a detection device to solve the above problems. Summary of the Invention

[0005] To address the shortcomings of the prior art, the present invention aims to provide an ion guide rod and detection device that ensures the axial spacing between the ion guide rod and the skimmer cone to a precision of 0.1 mm, eliminating errors caused by assembly dimensional chains. This structurally optimizes mass spectrometer performance, reduces inter-unit variability during the production and assembly process, and enables adjustment of the ion guide rod length within the vacuum chamber without removing the ion optical track, significantly simplifying the adjustment process and improving assembly efficiency.

[0006] To achieve these objects and other advantages according to the present invention, there is provided an ion guide rod comprising: a support column;

[0007] a tip tube disposed on the support column;

[0008] Wherein, an adjustment tube is provided between the support column and the tip tube, the adjustment tube is sleeved on the outer circumference of the support column, and different adjustment tubes have different lengths.

[0009] Preferably, the length difference between different adjusting tubes is 0.1 mm.

[0010] Preferably, the support column includes a first end and a second end that are arranged opposite to each other, the first end of the support column is provided with a connecting portion, and the tip tube and the adjustment tube are detachably sleeved on the outer periphery of the connecting portion.

[0011] Preferably, the tip tube is provided with a chamfered section, a middle section and a fixed section in sequence along its axial direction, and the chamfered section, the middle section and the fixed section are integrally formed.

[0012] Preferably, a fixing groove is provided on the fixing section, and a first threaded hole is provided on the connecting portion;

[0013] The ion guide rod further includes a pressing member, which passes through the fixing groove to be threadedly connected to the first threaded hole.

[0014] Preferably, a second threaded hole is provided at the second end of the support column, and the support column is fixedly connected to a connecting seat of an external ion optical guide rail through the second threaded hole.

[0015] On the other hand, the present invention further provides a detection device, comprising: an ion guide rod as described in any one of the above items;

[0016] a ruler disposed on the ion guide rod; and

[0017] a skimmer cone, wherein a central hole is formed in a central region of the skimmer cone, and the measuring ruler extends into the central hole;

[0018] Wherein, the ruler is provided with a measuring section, and the measuring section extends into the central hole.

[0019] Preferably, the ruler is further provided with a connecting section, and the connecting section is detachably connected to the chamfering section.

[0020] Preferably, the ruler is further provided with a limiting segment, and the outer diameter of the limiting segment is larger than the inner diameter of the inscribed circle enclosed by the chamfered segment.

[0021] One of the above-mentioned technical solutions has the following advantages or beneficial effects: The present invention can strictly guarantee the axial spacing between the ion guide rod and the skimmer cone with an accuracy of 0.1 mm, eliminating errors caused by assembly dimensional chains. This structurally optimizes mass spectrometer performance, reduces inter-unit variability during the production and assembly process, and enables the ion guide rod length to be adjusted within the vacuum chamber without removing the ion optical track, significantly simplifying the adjustment process and improving assembly efficiency.

[0022] Other advantages, objectives and features of the present invention will be reflected in part from the following description and will be understood by those skilled in the art through study and practice of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the following briefly introduces the drawings of the embodiments. Obviously, the drawings described below only relate to some embodiments of the present invention and are not intended to limit the present invention.

[0024] Figure 1 A three-dimensional structural diagram of an ion guide rod according to one embodiment of the present invention;

[0025] Figure 2 An exploded view of an ion guide rod according to one embodiment of the present invention;

[0026] Figure 3 is a cross-sectional view of an ion guide rod according to one embodiment of the present invention;

[0027] Figure 4 A structural diagram of a detection device according to one embodiment of the present invention;

[0028] Figure 5 FIG. 1 is a structural diagram of a measuring ruler according to an embodiment of the present invention. DETAILED DESCRIPTION

[0029] The following will be combined with the accompanying drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the embodiments described are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0030] In the drawings, the shapes and dimensions may be exaggerated for clarity, and the same reference numerals will be used throughout to designate the same or like components.

[0031] Unless otherwise defined, the technical or scientific terms used herein shall have the usual meanings understood by persons of ordinary skill in the field to which the invention belongs. The words "first", "second" and similar terms used in the patent application specification and claims of the present invention do not indicate any order, quantity or importance, but are only used to distinguish different components. Similarly, words such as "one", "an" or "the" do not indicate a quantity limitation, but rather indicate the existence of at least one. Words such as "include" or "comprise" mean that the elements or objects appearing before "include" or "comprises" cover the elements or objects listed after "include" or "comprises" and their equivalents, and do not exclude other elements or objects. "Up", "down", "left", "right" and the like are only used to indicate relative positional relationships. When the absolute position of the described object changes, the relative positional relationship may also change accordingly.

[0032] In the following description, words such as center, thickness, height, length, front, back, rear, left, right, top, bottom, upper, lower, etc. are defined relative to the structure shown in the drawings. In particular, "height" is equivalent to the dimension from top to bottom, "width" is equivalent to the dimension from left to right, and "depth" is equivalent to the dimension from front to back. They are relative concepts and may therefore change accordingly depending on their different positions and different usage states. Therefore, these or other directions should not be interpreted as restrictive terms.

[0033] Terms related to attachment, coupling, and the like (eg, "connected" and "attached") refer to relationships in which structures are directly or indirectly fixed or attached to one another through intermediate structures, as well as movable or rigid attachments, unless expressly stated otherwise.

[0034] According to one embodiment of the present invention, Figures 1-3 As shown in FIG. 1 , it can be seen that the ion guide rod 100 includes: a support column 110; and

[0035] a tip tube 120 , which is disposed on the support column 110 ;

[0036] An adjustment tube 130 is provided between the support column 110 and the tip tube 120 . The adjustment tube 130 is sleeved on the outer circumference of the support column 110 , and different adjustment tubes 130 have different lengths.

[0037] It can be understood that in the present invention, by providing adjustment tubes 130 of different lengths, the overall length of the ion guide rod 100 can be made different, and the length of the ion guide rod 100 can be adjusted, which is applicable to different occasions and has universality.

[0038] Furthermore, the length difference between different adjustment tubes 130 is 0.1 mm.

[0039] Furthermore, the support column 110 includes a first end and a second end that are arranged opposite to each other. The first end of the support column 110 is provided with a connecting portion 111 , and the tip tube 120 and the adjustment tube 130 are detachably sleeved on the outer periphery of the connecting portion 111 .

[0040] Furthermore, the tip tube 120 is sequentially provided with a chamfered section 121 , a middle section 122 and a fixed section 123 along the axial direction thereof, and the chamfered section 121 , the middle section 122 and the fixed section 123 are integrally formed.

[0041] Furthermore, a fixing groove 1231 is formed on the fixing section 123, and a first threaded hole 1111 is formed on the connecting portion 111;

[0042] The ion guide rod 100 further includes a pressing member 140 , which passes through the fixing groove 1231 to be threadedly connected to the first threaded hole 1111 .

[0043] It can be understood that in the present invention, the tip tube 120 and the adjustment tube 130 are fixedly mounted on the support column 110 by the cooperation between the pressing member 140 and the first threaded hole 1111.

[0044] When the adjusting tube 130 needs to be replaced, the staff can loosen the pressing piece 140 , disassemble the tip tube 120 and the adjusting tube 130 , and replace the adjusting tube 130 .

[0045] Furthermore, a second threaded hole is provided at the second end of the support column 110 , and the support column 110 is fixedly connected to a connection seat of an external ion optical guide rail through the second threaded hole.

[0046] On the other hand, combined Figures 4 and 5 , the present invention also provides a detection device, comprising: the ion guide rod 100 as described in any one of the above items;

[0047] a ruler 200 disposed on the ion guide rod 100; and

[0048] A skimmer cone 300, wherein a central hole is formed in the central region of the skimmer cone 300, and the ruler 200 extends into the central hole;

[0049] The ruler 200 is provided with a measuring section 210 , and the measuring section 210 extends into the central hole.

[0050] It can be understood that in the present invention, the distance between the skimmer cone 300 and the ion guide rod 100 can be obtained by measuring the distance that the segment 210 extends into the central hole of the skimmer cone 300, thereby facilitating adjustment of the distance between the skimmer cone 300 and the ion guide rod 100.

[0051] Furthermore, the ruler 200 is further provided with a connecting section 220, which is detachably connected to the chamfered section 121. By detachably connecting the connecting section 220 and the chamfered section 121, the ion guide rod 100 can be removed and replaced when the adjustment tube 130 needs to be replaced.

[0052] Furthermore, the ruler 200 is further provided with a limiting section 230 , and the outer diameter of the limiting section 230 is larger than the inner diameter of the inscribed circle enclosed by the chamfered section 121 .

[0053] In summary, the present invention ensures a precise axial spacing between the ion guide rod and the skimmer cone, achieving an accuracy of 0.1 mm and eliminating errors caused by assembly dimensional chains. This structurally optimizes mass spectrometer performance and reduces inter-unit variability during the production and assembly process. Furthermore, the ion guide rod length can be adjusted within the vacuum chamber without removing the ion optical track, significantly simplifying the adjustment process and improving assembly efficiency.

[0054] The number of devices and processing scales described herein are intended to simplify the description of the present invention. Applications, modifications, and variations of the present invention will be readily apparent to those skilled in the art.

[0055] Although the embodiments of the present invention have been disclosed above, they are not limited to the applications listed in the specification and exemplary embodiments. They can be applied to a variety of fields suitable for the present invention. Further modifications will be readily apparent to those skilled in the art. Therefore, the present invention is not limited to the specific details and illustrations shown and described herein without departing from the general concept defined by the claims and their equivalents.

Claims

1. A detection device, characterized in that: include: An ion guide rod, comprising a support column (110) and a tip tube (120) disposed on the support column (110); wherein an adjustment tube (130) is disposed between the support column (110) and the tip tube (120), the adjustment tube (130) being sleeved on the outer circumference of the support column (110), and different adjustment tubes (130) having different lengths; A ruler (200) is provided on the ion guide rod; A skimmer cone (300), wherein a central area of the skimmer cone (300) is provided with a central hole, and the ruler (200) extends into the central hole; Wherein, the ruler (200) is provided with a measuring section (210), and the measuring section (210) extends into the central hole; The length difference between different regulating tubes (130) is 0.1 mm; The support column (110) comprises a first end and a second end arranged opposite to each other. The first end of the support column (110) is provided with a connecting portion (111). The tip tube (120) and the adjustment tube (130) are detachably sleeved on the outer periphery of the connecting portion (111).

2. The detection device according to claim 1, wherein The tip tube (120) is provided with a chamfered section (121), a middle section (122) and a fixed section (123) in sequence along its axial direction; the chamfered section (121), the middle section (122) and the fixed section (123) are integrally formed.

3. The detection device according to claim 2, wherein: A fixing groove (1231) is provided on the fixing section (123), and a first threaded hole (1111) is provided on the connecting portion (111); The ion guide rod further comprises a pressing member (140), wherein the pressing member (140) passes through the fixing groove (1231) to be threadedly connected to the first threaded hole (1111).

4. The detection device according to claim 1, wherein A second threaded hole is provided at the second end of the support column (110), and the support column (110) is fixedly connected to a connecting seat of an external ion optical guide rail through the second threaded hole.

5. The detection device according to claim 2, wherein: The measuring ruler (200) is further provided with a connecting section (220), and the connecting section (220) is detachably connected to the chamfering section (121).

6. The detection device according to claim 2, wherein: The measuring ruler (200) is further provided with a limiting section (230), wherein the outer diameter of the limiting section (230) is larger than the inner diameter of the inscribed circle enclosed by the chamfered section (121).

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