A coating device for producing implantable biosensors

Abstract

The present invention discloses a coating device for the production of implantable biosensors, comprising a workbench, a coating chamber fixed on the workbench, a sensor link positioning mechanism, a coating mechanism, a film liquid storage mechanism, a cleaning mechanism and a material storage mechanism fixed in the coating chamber, the coating mechanism comprising a coating component for storing droplet-shaped film liquid and a coating drive component for driving the coating component to perform a coating operation, which can realize the operation of the automatic coating process of the implantable biosensor, and the film liquid is stored in the coating component in the form of drops and then the sensor link is coated in batches instead of the traditional film form, the integrity of the package, the uniformity and stability of the coating are better, and at the same time, because the amount of droplet-shaped film liquid captured by the coating cavity is much larger than the amount of film-shaped film liquid, the number of coating times can be reduced, thereby greatly improving production efficiency.

Description

Technical Field

[0001] The present invention relates to the technical field of implantable biosensors, and in particular to a film coating device for producing implantable biosensors. Background Art

[0002] Blood sugar monitoring is crucial for diabetic patients, as blood sugar levels can help assess glucose metabolism disorders. Currently, blood sugar testing can be divided into in vitro testing after blood sampling and real-time monitoring using implantable blood sugar sensors. In vitro testing requires multiple daily blood draws, placing a heavy burden on patients both mentally and physically. Consequently, real-time monitoring using implantable blood sugar sensors is becoming increasingly popular.

[0003] Currently, the only continuous blood glucose monitoring products that can be used in clinical practice and have been technically verified to a certain extent are microsensors implanted in subcutaneous tissue. Due to the small and soft characteristics of implantable biosensors, in order to improve efficiency and facilitate processing during production, multiple implantable biosensors are made into sensor chains. At this time, corresponding equipment is needed. For example, the Chinese utility model patent with patent number CN201920221865.9 and application date 2019-02-22 discloses a biosensor coating tooling, including a cavity, a membrane liquid tank and a needle holding plate fixing assembly are provided in the cavity, the needle holding plate fixing assembly is connected to a pull rod, and the pull rod is externally connected to a lifting device, and the lifting device controls the pull rod to drive the needle holding plate fixing assembly to move up and down in the cavity, and a sensor is provided on the needle holding plate fixing assembly, and the sensor and the membrane liquid tank are arranged correspondingly. This utility model controls the pull rod through a lifting device to drive the needle holding plate fixing assembly to move up and down in the cavity, thereby placing the sensor fixed on the needle holding plate fixing assembly in the membrane liquid tank in the cavity to complete the coating. Although it has improved production efficiency, the uniformity of the coating is not good enough, and it can only be applied to the preparation of rigid, irregular and short sensors. The coated sensor must have high rigidity and will not bend due to resistance during the process of passing through the coating. It can only be used when one end is fixed, and the length of the processed sensor is limited. Therefore, these devices and principles cannot be applied to the industrial production process of general sensors. Biosensors using flexible substrates are a milestone in the development of dynamic monitoring technology. Their flexible physical properties are extremely important for the performance of implantable sensors. Compared with rigid sensors, flexible sensors have many advantages, such as: no rigid stimulation to human tissue, no interference from human body movements, and can be bent arbitrarily, etc. The production of flexible sensors requires the ability to fix both ends of the sensor and perform three-dimensional uniform operation on the sensor in order to maintain uniform processing and coating of the sensor during the processing. The Chinese utility model patent with publication number CN201823669U discloses a fully automatic integrated coating machine, which includes a base and a coating chamber arranged on the base, as well as a horizontal motion mechanism and a vertical motion mechanism. The coating chamber is provided with an electrode holder assembly, which is respectively connected to the horizontal motion mechanism and the vertical motion mechanism. However, since this utility model patent uses a membrane liquid ring to coat the film, it is still impossible to operate the workpiece with both ends fixed during operation, or if the two ends of the sensor are fixed, the coating ring cannot pass through the sensor to perform the coating work.

[0004] The Chinese invention patent with publication number CN104941859B discloses a sensor coating device, which uses a coating clamp for coating. A coating gap can be set in the middle of the coating clamp for coating the workpiece after immersion in liquid. The liquid forms a thin film in the coating gap. First, the wrapping property of the liquid film is not enough. Second, the amount of liquid captured by the coating clamp is also limited, so the number of coating times needs to be increased accordingly. Finally, the thickness of the liquid film is uneven under the traction of gravity and surface tension, and it is easy to be thin on the top and thick on the bottom. This causes uneven film thickness on the surface of the sensor electrode during coating. The biofilm on the electrode surface itself is relatively thin, and a small thickness difference may have a great impact on the detection accuracy of the sensor electrode.

[0005] Therefore, there is an urgent need for a coating device for producing implantable biosensors. Summary of the Invention

[0006] To solve the above problems, the present invention provides a coating device for producing an implantable biosensor.

[0007] A coating device for producing an implantable biosensor comprises a workbench provided with a coating chamber for enclosing a coating operation space, wherein the coating chamber is fixed with a sensor link positioning mechanism for positioning and fixing a sensor link, a film liquid storage mechanism for sealingly storing a film liquid, and a film coating mechanism, wherein the film coating mechanism comprises a film coating assembly for storing a droplet of film liquid and a film coating drive assembly for driving the film coating assembly to perform a film coating operation;

[0008] The coating assembly includes a mounting portion and a coating portion formed on the mounting portion, the coating portion having a coating cavity formed thereon for storing a droplet of film liquid, a coating channel for passing an implantable biosensor is formed on a side of the coating portion away from the mounting portion, and the coating channel is in communication with the coating cavity;

[0009] The coating drive assembly includes a driving bracket, a cross slide is fixed on the driving bracket, a movable seat is slidably connected to the cross slide, and a coating assembly clamping mechanism for clamping and moving the coating assembly and a sensor link adsorption mechanism for adsorbing and moving the sensor link are respectively fixed at both ends of the movable seat;

[0010] The coating part includes a first grabbing part, a second grabbing part and a grabbing connection part that transitionally connects the first grabbing part and the second grabbing part. The surfaces of the first grabbing part, the second grabbing part and the grabbing connection part close to the coating cavity are all rough surfaces, and mounting blocks are formed on both sides of the mounting part.

[0011] Preferably, the sensor link positioning mechanism includes a positioning seat for accommodating the sensor link, the positioning seat is provided with a fixed positioning mechanism and a synchronous positioning mechanism cooperating with the fixed positioning mechanism, the fixed positioning mechanism includes a transverse positioning baffle and a longitudinal positioning baffle fixed on adjacent two sides of the positioning seat, the synchronous positioning mechanism includes a transverse positioning pushing mechanism cooperating with the transverse positioning baffle, a longitudinal positioning pushing mechanism cooperating with the longitudinal positioning baffle, and a positioning driving mechanism for driving the transverse positioning pushing mechanism and the longitudinal positioning pushing mechanism to move.

[0012] Preferably, the membrane liquid storage mechanism includes a membrane liquid pool and a membrane liquid cover hingedly connected to the membrane liquid pool.

[0013] Preferably, a cleaning mechanism is fixed in the coating chamber, and the cleaning mechanism includes a stirring cleaning pool and an air blowing pool which are arranged and fixed with the film liquid pool.

[0014] Preferably, the coating chamber is fixed with a material storage mechanism, which includes a movable material storage base and a material driving mechanism for driving the material storage base to move out of or into the coating chamber, and a material storage bin and a material discharge bin are fixed on the material storage base.

[0015] Preferably, the coating mechanism includes a coating component placement groove for placing and cleaning the coating component, and the coating component placement groove is provided with multiple groups of card slots that cooperate with the installation card blocks.

[0016] Preferably, the transverse positioning pushing mechanism includes a transverse connecting block fixed to the positioning driving mechanism, a transverse pushing plate is hinged on the transverse connecting block, and a transverse pushing wheel is hinged on the transverse pushing plate; the longitudinal positioning pushing mechanism includes a longitudinal connecting block fixed to the positioning driving mechanism, a longitudinal pushing plate is hinged on the longitudinal connecting block, and a longitudinal pushing wheel is hinged on the longitudinal pushing plate.

[0017] The beneficial effects of the present invention are:

[0018] (1) The present invention discloses a coating device for producing implantable biosensors, comprising a workbench, a coating chamber fixed on the workbench, a sensor link positioning mechanism, a coating mechanism, a film liquid storage mechanism, a cleaning mechanism and a material storage mechanism fixed in the coating chamber, the coating mechanism comprising a coating component for storing droplet-shaped film liquid and a coating drive component for driving the coating component to perform a coating operation, which can realize the operation of the automatic coating process of the implantable biosensor, and the film liquid is stored in the coating component in the form of drops and then the sensor link is coated in batches instead of the traditional film form, the integrity of the package, the uniformity and stability of the coating are better, and at the same time, since the amount of droplet-shaped film liquid captured by the coating cavity is much larger than the amount of film-shaped film liquid, the number of coating operations can be reduced, thereby greatly improving production efficiency.

[0019] (2) The present invention discloses a coating device for producing implantable biosensors, which includes a sensor link positioning mechanism, wherein the sensor link positioning mechanism includes a positioning seat for accommodating the sensor link, and the positioning seat is provided with a fixed positioning mechanism and a synchronous positioning mechanism coordinated with the fixed positioning mechanism. The synchronous positioning mechanism cooperates with the fixed positioning mechanism to achieve rapid and accurate positioning of the sensor link, thereby ensuring the efficiency and effect of the sensor link coating process.

[0020] (3) The present invention discloses a coating device for producing implantable biosensors, which includes a cleaning mechanism for cleaning the coating assembly to ensure the cleanliness of the coating assembly each time the coating operation is performed without affecting the film liquid.

[0021] (4) The present invention discloses a coating device for the production of implantable biosensors, which includes a material storage mechanism. Sensors can be stacked and stored on the base, and the sealing of the coating chamber will not be affected by frequent feeding and discharging. Automatic batch feeding and discharging of sensors is achieved, and a first sealing plate and a second sealing plate are formed on both sides of the base, which effectively ensure the sealing of the coating chamber, further reduce the loss of the coating due to volatility, and save coating materials. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] Figure 1 is a perspective view of the coating assembly of the present invention;

[0023] Figure 2 for Figure 1 A in the middle is an enlarged schematic diagram;

[0024] Figure 3 Another shape of the coating portion of the present invention;

[0025] Figure 4 A schematic diagram of a sensor connection of the present invention;

[0026] Figure 5 A three-dimensional diagram of a coating device for producing an implantable biosensor according to the present invention;

[0027] Figure 6 This is a schematic diagram of the internal structure of a coating device for producing an implantable biosensor according to the present invention;

[0028] Figure 7 It is a schematic diagram of the three-dimensional structure of the sensor joint positioning mechanism of the present invention;

[0029] Figure 8 It is a schematic diagram of the three-dimensional structure of the material storage mechanism of the present invention;

[0030] Figure 9 It is a schematic diagram of the three-dimensional structure of the membrane liquid storage mechanism of the present invention;

[0031] Figure 10 It is a schematic diagram of the three-dimensional structure of the coating drive assembly of the present invention;

[0032] Figure 11 This is a schematic diagram of the three-dimensional structure of the coating assembly placement tank of the present invention;

[0033] Figure 12 It is a schematic diagram of the three-dimensional structure of the sensor-adsorption mechanism of the present invention;

[0034] Figure 13 It is a schematic diagram of the three-dimensional structure of the pressing plate of the present invention.

[0035] In the figure: mounting portion 1; coating portion 2; connecting portion 3; coating cavity 4; unit frame 5; unit frame 51; implantable biosensor 52; electrode portion 53; flexible detection portion 54; coating channel 6; first gripping portion 7; second gripping portion 8; gripping connecting portion 9; mounting block 10; pressing plate 12; workbench a1; coating chamber a2; sensor joint positioning mechanism a3; positioning seat a31; fixed positioning mechanism a32; synchronous positioning mechanism a33; horizontal positioning baffle a34; vertical positioning baffle a35; horizontal positioning pushing mechanism a36; horizontal connecting block a361; horizontal pushing plate a362; horizontal pushing wheel a363; vertical positioning pushing mechanism a37; vertical connecting block a371; vertical pushing plate a372; vertical Towards the pushing wheel a373; coating mechanism a4; coating assembly a41; coating drive assembly a42; coating assembly placement groove a43; film liquid storage mechanism a5; film liquid pool a51; drive bracket a6; cross slide a61; moving seat a62; coating assembly clamping mechanism a63; sensor-linked adsorption mechanism a64; adsorption plate a641; vent pipe a642; adsorption compression spring a643; suction cup a644; cleaning mechanism a7; stirring and cleaning pool a71; blowing pool a72; material storage mechanism a8; material storage base a81; material drive mechanism a82; storage bin a83; discharge bin a84; first sealing plate a85; second sealing plate a86; reset spring a39; limit extension block a391. DETAILED DESCRIPTION

[0036] The present invention is further described below with reference to the accompanying drawings. The embodiments described are only some embodiments of the present invention, not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0037] In the description of the present invention, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", "clockwise", "counterclockwise" and the like, indicating orientations or positional relationships, are based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as limiting the present invention. In addition, the terms "first" and "second" are used for descriptive purposes only, and cannot be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features defined as "first" and "second" may explicitly or implicitly include one or more of the said features. In the description of the present invention, the meaning of "multiple" is two or more, unless otherwise clearly and specifically defined.

[0038] For the sake of production efficiency, the present invention adopts a batch production mode for the production of an implantable biosensor, and the implantable biosensor is made into a sensor unit, which includes a unit frame 5, and the unit frame 5 includes a unit frame 51. A plurality of implantable biosensors 52 (the plurality includes three or more) are fixedly connected side by side to the unit frame 51. The upper surface of each implantable biosensor 52 is maintained in the same plane as the upper surface of the unit frame 51. Each implantable biosensor 52 includes an electrode portion 53 and a flexible detection portion 54. The implantable biosensor 52 has been described in the existing patent CN201310724053.3 "Subcutaneous Tissue Sensor Device with Controllable Implantation Angle" and is therefore not described in detail in this case. The end of the electrode portion 53 of the implantable biosensor 52 away from the flexible detection portion 54 is connected to the unit frame 51, and the end of the flexible detection portion 54 of the implantable biosensor 52 away from the electrode portion 53 is connected to the unit frame 51, that is, both ends of the implantable biosensor 52 are fixed to the unit frame 51. The size and shape of the pressing plate 12 match those of the unit frame 51 . The pressing plate 12 is used to fix both ends of the implantable biosensor 52 when the coating assembly performs a coating operation on the implantable biosensor 52 .

[0039] The existing sensor coating method generally adopts the immersion method. For example, the Chinese utility model patent with patent number CN201920221865.9 and application date of 2019-02-22 discloses a biosensor coating tool, which immerses the sensor into the coating liquid in the liquid tank for coating, and then pulls the sensor up after coating. The first problem of this operation method is that the coating efficiency is not high enough, because it needs to be coated in the coating liquid and then pulled up. The pulling-up process is relatively slow, because if the speed is too fast, it will affect the coating. The effect affects the uniformity of the coating. Secondly, during the pulling process, because the sensor is set vertically, the coating liquid is affected by gravity, and the coating liquid accumulates during the slow pulling process, affecting the coating effect and causing unevenness of the sensor coating. Finally, a ring-shaped coating method is adopted. This method is suitable for a needle-shaped sensor with one end fixed. Therefore, the needle-shaped sensor must have high rigidity and will not bend due to resistance when passing through the coating. It can only be used when one end is fixed, and the length of the processed sensor is limited.

[0040] The existing sensor coating method is based on the principle that the sensor passes through a "liquid film" for coating. For example, the Chinese invention patent with publication number CN104941859B discloses a sensor coating device, which is coated with a coating clamp. A coating gap can be set in the middle of the coating clamp for coating the workpiece after immersion in liquid. The liquid forms a thin film in the coating gap. First, the wrapping property of the liquid film is not enough. Secondly, the amount of liquid captured by the coating clamp is also limited, so the number of coating times required will also increase accordingly. Finally, the thickness of the liquid film is uneven under the traction of gravity and surface tension, and it is easy to be thin on the top and thick on the bottom. This causes uneven film thickness on the surface of the sensor electrode during coating. The biofilm on the electrode surface itself is relatively thin, and a small thickness difference may have a great impact on the detection accuracy of the sensor electrode.

[0041] A coating device for implantable biosensor production uses a droplet-shaped coating solution to batch coat sensor links. This coating solution improves the wrapping, stability, and uniformity of the coated layer, reduces the number of coating passes, and significantly improves production efficiency. The device comprises a workbench a1, a coating chamber a2 enclosing the coating operation space. Within the coating chamber a2 are a sensor link positioning mechanism a3, a coating mechanism a4, a coating solution storage mechanism a5, a cleaning mechanism a7, and a material storage mechanism a8.

[0042] Specifically, the sensor link positioning mechanism a3 is used to position and fix the sensor link, and can realize fast and accurate positioning of the sensor link, ensuring the speed and effect of the sensor link coating. It includes a positioning seat a31 for accommodating the sensor link, and the positioning seat a31 is provided with a fixed positioning mechanism a32 and a synchronous positioning mechanism a33 cooperating with the fixed positioning mechanism a32. The fixed positioning mechanism a32 includes a transverse positioning baffle a34 and a longitudinal positioning baffle a35 fixed on the adjacent two sides of the positioning seat a31. The synchronous positioning mechanism a33 includes a transverse positioning pushing mechanism a36 cooperating with the transverse positioning baffle a34, a longitudinal positioning pushing mechanism a37 cooperating with the longitudinal positioning baffle a35, and a positioning driving mechanism a38 for driving the transverse positioning pushing mechanism a36 and the longitudinal positioning pushing mechanism a37 to move. The positioning driving mechanism a38 can be a four-claw cylinder, which is a conventional technology in this field, so it will not be elaborated on. The transverse positioning baffle a34 positions the transverse direction of the sensor link, and the longitudinal positioning baffle a35 positions the longitudinal direction of the sensor link. The two cooperate to achieve the initial positioning of the sensor link. The transverse positioning pushing mechanism a36 includes a transverse connecting block a361 fixed to the positioning drive mechanism a38, and a transverse pushing plate a362 is hinged on the transverse connecting block a361. The transverse pushing plate a362 is rotatably connected to the transverse pushing wheel a363. The positioning drive mechanism 38 drives the transverse pushing plate a362 to move toward the positioning seat a31 where the sensor link is placed through the transverse connecting block a361, and the transverse pushing wheel a363 rotates to push the sensor link. The dynamic sensor link moves toward the horizontal positioning baffle a34 for further horizontal precise positioning. The longitudinal positioning driving mechanism a37 includes a longitudinal connecting block a371 fixed to the positioning drive mechanism a38. The longitudinal connecting block a371 is hingedly connected to a longitudinal pushing plate a372, and the longitudinal pushing plate a372 is hingedly connected to a longitudinal pushing wheel a373. The positioning drive mechanism 38 drives the longitudinal pushing plate a372 to move toward the positioning seat a31 on which the sensor link is placed through the longitudinal connecting block a371. The longitudinal pushing wheel a373 rotates to push the sensor link toward the longitudinal positioning baffle a35 for further vertical precise positioning. There are two horizontal pushing plates a362 and two longitudinal pushing plates a372. A return spring a39 is fixed between the two horizontal pushing plates a362 and the two longitudinal pushing plates a372. This not only resets the horizontal pushing plates a362 but also limits the rotation angle of the horizontal pushing plates a362.The end of the transverse connecting block a361 away from the positioning seat a31 and the end of the longitudinal connecting block a371 away from the positioning seat a31 are both formed with a limiting extension block a391, which is used to limit the moving range of the four-claw cylinder so as to limit the moving position of the transverse push plate a362 and the longitudinal push plate a372, thereby achieving precise positioning without excessive extrusion on the sensor link, thereby protecting the sensor link.

[0043] Specifically, the coating mechanism a4 includes a coating component a41 for storing droplet-shaped film liquid, a coating drive component a42 for driving the coating component a41 to perform coating operations, and a coating component placement tank a43 for placing and cleaning the coating component a41.

[0044] The coating assembly a41 includes a mounting portion 1, on which a coating portion for grabbing the film liquid in a drop shape is formed, and on which a coating cavity 4 for storing the drop-shaped film liquid is formed. A coating channel 6 for the implantable biosensor 52 to pass through is formed on the side of the coating portion 2 away from the mounting portion 1. The coating channel 6 is connected to the coating cavity 4, so that the implantable biosensor 52 enters from the coating channel 6 and passes through the drop-shaped film liquid stored in the coating cavity 4 from bottom to top, so that the drop-shaped film liquid completely wraps the implantable biosensor 52.

[0045] The coating drive assembly a42 includes a driving bracket a6, a cross slide a61 is fixed on the driving bracket a6, a moving seat a62 is slidably connected to the cross slide a61, and a coating assembly clamping mechanism a63 for clamping and moving the coating assembly a41 and a sensor link adsorption mechanism a64 for adsorbing and moving the sensor link are respectively fixed at both ends of the moving seat a62;

[0046] The coating component placement groove a43 contains a cleaning liquid for cleaning the coating component a41, and the solution can be tetrahydrofuran. The coating component placement groove a43 is provided with multiple groups of card slots that cooperate with the installation block 10. When the coating component is placed in the coating component placement groove a43, it is used for further soaking and cleaning the coating component, and the coating component placement groove a43 is connected to an external container containing cleaning liquid through an injection pump, and the cleaning liquid in the coating component placement groove a43 is continuously replaced, and the cleaning liquid therein is in a flowing state, which is more conducive to the cleanliness of cleaning.

[0047] Specifically, the coating portion 2 includes a first gripping portion 7, a second gripping portion 8, and a gripping connection portion 9 that transitionally connects the first gripping portion 7 and the second gripping portion 8. The gripping connection portion 9 can prevent the gripped droplet-shaped membrane liquid from deforming, because the implantable biosensor 52 generates an upward squeezing force on the membrane liquid during the process of passing from bottom to top. If the gripping connection portion 9 does not exist, the membrane liquid will be squeezed upward or deformed due to its own tension. The gripping connection portion 9 is in the shape of an arc, a triangle, a wavy arc, a trapezoid, etc. The first gripping portion 7 can be in the shape of a straight line, a wavy line, an arc, etc. The second gripping portion 8 can be in the shape of a straight line, a wavy line, an arc, etc. As long as the coating portion 2 can hold the membrane liquid in the form of drops in the coating cavity 4, it can be any combination of shapes. Figure 3 The schematic diagram of another shape thereof shows that the surfaces of the first grabbing portion 7, the second grabbing portion 8 and the grabbing connecting portion 9 close to the coating cavity 4 are all rough surfaces. Due to the roughness, friction can be generated to overcome the gravity of the membrane liquid. The number of the coating portions 2 is 3 or more, and a plurality of the coating portions 2 are arranged in parallel on the mounting portion 1. The number and arrangement spacing of the coating portions 2 are matched with the implantable biosensor 52 on the sensor link. The coating portion 2 is transitionally connected to the mounting portion 1 through the connecting portion 3. Mounting blocks 10 are formed on both sides of the mounting portion 1 to facilitate the placement of the coating assembly. The coating assembly can be placed by simply locking the mounting block 10 in the card slot.

[0048] Specifically, the coating component clamping mechanism a63 and the sensor-coupled adsorption mechanism a64 are fixedly connected to the movable seat a62 through a vertical driving mechanism. The vertical driving mechanism can be a cylinder, or it can be a driving mechanism that drives a screw pair driven by a motor, etc., as long as it can drive the coating component clamping mechanism a63 or the sensor-coupled adsorption mechanism a64 to move up and down.

[0049] Specifically, the coating component clamping mechanism a63 can realize the action of clamping or loosening the coating component, and realizes the coating operation of the implantable biosensor 52 by transporting and shifting the coating component. The coating component clamping mechanism a63 includes a pneumatic clamp and a clamping plate fixed to the pneumatic clamp. The clamping and loosening actions are realized by the two clamping plates. The pneumatic clamp is a conventional technology in this field, so it will not be elaborated in detail. The sensor link adsorption mechanism a64 includes an adsorption plate a641, on which a plurality of adsorption parts are fixed, and the adsorption parts include a vent tube a642, an adsorption compression spring a643 sleeved on the vent tube a642, and a suction cup a644 connected to the vent tube a642. After the suction cup a644 contacts the sensor link or the pressure plate 12, the adsorption force generated by it is used to achieve the displacement and transportation of the sensor link or the pressure plate 12. The setting of the adsorption compression spring a643 ensures that it is in elastic contact with the sensor link or the pressure plate 12 when in contact, and does not generate a relatively large impact, thereby ensuring that the sensor link will not be damaged and ensuring the stability when transporting the sensor link or the pressure plate 12.

[0050] Specifically, the membrane liquid storage mechanism a5 includes a membrane liquid pool a51 and a membrane liquid cover hingedly connected to the membrane liquid pool a51. The membrane liquid cover is opened or closed by a control system, that is, when the membrane material needs to be taken, the membrane liquid cover automatically opens. This structure is conducive to the sealed preservation of the membrane liquid and reduces its consumption due to volatilization.

[0051] Specifically, the cleaning mechanism a7 includes a stirring cleaning pool a71 and a blowing pool a72 arranged and fixed with the membrane liquid pool a51. The stirring cleaning pool a71 includes a magnetic stirrer. The magnetic stirrer continuously stirs the cleaning liquid in the stirring cleaning pool a71, causing it to flow in a large scale, flushing and cleaning the coating component, improving the cleanliness and cleaning efficiency of the cleaning. The stirring cleaning pool a71 is connected to an external container containing cleaning liquid through an injection pump, so that the cleaning liquid in the stirring cleaning pool a71 can flow, continuously entering clean cleaning liquid and allowing unclean cleaning liquid to flow out. The blowing pool a72 includes a blowing pool body for accommodating the coating component. A plurality of blowing ports are provided on the inner wall of one side of the blowing pool body. The blowing ports are connected to the air inlet pipe. The setting of the blowing pool a72 flushes the residual cleaning liquid or membrane liquid on the coating component through the impact force of the airflow.

[0052] Specifically, the material storage mechanism a8 includes a movable material storage base a81 and a material driving mechanism a82 for driving the material storage base a81 to move out of or into the coating chamber a2. The material driving mechanism a82 can be a linear slide rail. The material storage base a81 is formed with a storage bin a83 for storing the sensor link to be coated and a discharge bin a84 for storing the sensor link and the pressure plate 12 after the coating is completed. The base a81 is formed with a first sealing plate a85 on both sides perpendicular to its moving direction. And the second sealing plate a86, the size and shape of the first sealing plate a85 and the second sealing plate a86 match the shape and size of the discharge port opened on the coating chamber a2. When no material is discharged, the first sealing plate a85 seals the coating chamber a2. When in the process of manual discharge or discharge, the second sealing plate a86 seals the coating chamber a2, effectively ensuring the sealing of the coating chamber a2, preventing the film liquid from emitting due to its own volatility, further reducing the loss of the coating due to volatility, and saving coating materials.

[0053] Specific operation process:

[0054] The first step: discharge; multiple sensors that need to be coated are stacked with the pressure plate 12 at intervals and stored in the storage bin a83, that is, one sensor is stacked on one pressure plate 12 as a group for stacking;

[0055] Step 2: Take the sensor link, the coating drive component a42 drives the sensor link adsorption mechanism a64 to move to the top of the storage bin a83, then the vertical drive mechanism drives the sensor link adsorption mechanism a64 to move downward, adsorbs and fixes the sensor link that needs coating, and the coating drive component a42 drives the sensor link adsorption mechanism a64 again to move to the top of the sensor link positioning mechanism a3, and places the adsorbed sensor link in the positioning seat a31;

[0056] Step 3: Take the pressure plate 12, the coating drive component a42 drives the sensor link adsorption mechanism a64 to move to just above the storage bin a83, then the vertical drive mechanism drives the sensor link adsorption mechanism a64 to move downward to adsorb and fix the pressure plate 12, the coating drive component a42 drives the sensor link adsorption mechanism a64 again to move above the sensor link positioning mechanism a3, and places the adsorbed pressure plate 12 on the sensor link (the pressure plate 12 can fix the sensor link and make the sensor link more flat, because the sensor link is made of flexible material, it is easy to bend and be uneven, so placing the pressure plate 12 on the sensor link to flatten the sensor link is more conducive to the coating effect);

[0057] Step 4: Precise positioning: the positioning drive mechanism a38 drives the synchronous positioning mechanism a33 to move toward the fixed positioning mechanism a32, pushing the sensor link and the pressure plate 12 placed on the positioning seat a31 to move toward the fixed positioning mechanism a32 for precise positioning;

[0058] Step 5: Grab the coating component a41 and apply the coating. The coating drive component a42 drives the coating component clamping mechanism a63 to move above the coating component placement slot a43. Then the vertical drive mechanism drives the coating component clamping mechanism a63 to move downward, clamp the coating component a41 and move it to the blowing pool a72 under the drive of the coating drive component a42. The cleaning liquid on the coating component a41 is blown away by the air flow, and then the coating component a41 is moved to the top of the film liquid storage mechanism a5. The sensor automatically opens the film liquid cover after sensing, and the coating component a41 moves to the film liquid pool a51 to pick up the film liquid, and the film liquid is stored in the coating space in the form of drops. In the cavity 4, the membrane liquid cover is automatically closed and finally moves to the top of the sensor joint adsorption mechanism a64. Under the drive of the vertical drive mechanism, the coating assembly clamping mechanism a63 moves downward, and the implantable biosensor 52 enters the coating channel 6. The coating assembly clamping mechanism a63 continues to move downward, and the implantable biosensor 52 enters the coating cavity 4. At this time, the membrane liquid completely wraps the implantable biosensor 52 due to its own tension. Finally, the coating drive component a42 drives the coating assembly clamping mechanism a63 to coat the implantable biosensor 52. The direction of the coating can be moving from the electrode part 53 to the flexible detection part 54.

[0059] Step 6: Clean the coating component a41. The coating drive component a42 drives the coating component clamping mechanism a63 to move above the stirring and cleaning tank a71. The vertical drive mechanism drives the coating component clamping mechanism a63 to repeatedly move up and down several times to oscillate and clean the residual film liquid. The coating drive component a42 and the vertical drive mechanism jointly move the coating component a41 into the blowing tank a72 to blow away the residual liquid. Finally, the coating component a41 is clamped in the card slot a44 and further immersed in the coating component placement slot a43 for cleaning.

[0060] Step 7: Material storage: Under the joint drive of the coating drive component a42 and the vertical drive mechanism, the pressure plate 12 is placed in the discharge bin a84 through the sensor joint adsorption mechanism a64. Then, under the joint drive of the coating drive component a42 and the vertical drive mechanism, the sensor joint with the coating completed is placed in the discharge bin a84 through the sensor joint adsorption mechanism a64.

[0061] Step 8: Repeat steps 2 to 7 above.

[0062] The present invention discloses an implantable biosensor coating device, which includes a sensor link positioning mechanism, a coating mechanism, a film liquid storage mechanism, a cleaning mechanism and a material storage mechanism. The coating mechanism includes a coating component for storing droplet-shaped film liquid and a coating drive component for driving the coating component to perform film coating operations. The device can realize the automatic coating process of the implantable biosensor, and the film liquid is stored in the coating component in the form of drops and then the sensor link is coated in batches instead of the traditional film form. The package integrity, coating uniformity and stability are better. At the same time, since the amount of droplet-shaped film liquid captured by the coating cavity is much larger than the amount of film-shaped film liquid, the number of coating operations can be reduced, thereby greatly improving production efficiency.

[0063] The above is merely a preferred embodiment of the present invention and is not intended to limit the present invention. Those skilled in the art will readily appreciate that the present invention is susceptible to various modifications and variations. Any modifications, equivalent substitutions, or improvements made within the spirit and principles of the present invention shall be included within the scope of protection of the present invention.

Claims

1. A coating device for producing an implantable biosensor, comprising a workbench (a1), wherein a coating chamber (a2) is provided on the workbench (a1) for enclosing a coating operation space, and characterized in that: A sensor link positioning mechanism (a3) ​​for positioning and fixing the sensor link, a film liquid storage mechanism (a5) for sealing and storing the film liquid, and a film coating mechanism (a4) are fixed in the film coating chamber (a2). The film coating mechanism (a4) includes a film coating component (a41) for storing droplet-shaped film liquid and a film coating drive component (a42) for driving the film coating component (a41) to perform a film coating operation. The coating assembly (a41) comprises a mounting portion (1) and a coating portion (2) formed on the mounting portion (1); a coating cavity (4) for storing a droplet-shaped film liquid is formed on the coating portion (2); a coating channel (6) for an implantable biosensor (52) to pass through is provided on a side of the coating portion (2) away from the mounting portion (1); the coating channel (6) is communicated with the coating cavity (4); The coating drive assembly (a42) includes a drive bracket (a6), a cross slide (a61) is fixed on the drive bracket (a6), a movable seat (a62) is slidably connected to the cross slide (a61), and a coating assembly clamping mechanism (a63) for clamping and moving the coating assembly (a41) and a sensor link adsorption mechanism (a64) for adsorbing and moving the sensor link are respectively fixed at both ends of the movable seat (a62); The coating portion (2) includes a first gripping portion (7), a second gripping portion (8), and a gripping connection portion (9) for transitionally connecting the first gripping portion (7) and the second gripping portion (8). The surfaces of the first gripping portion (7), the second gripping portion (8), and the gripping connection portion (9) close to the coating cavity (4) are all rough surfaces, and mounting blocks (10) are formed on both sides of the mounting portion (1).

2. The film coating device for producing an implantable biosensor according to claim 1, characterized in that: The sensor link positioning mechanism (a3) ​​includes a positioning seat (a31) for accommodating the sensor link, the positioning seat (a31) is provided with a fixed positioning mechanism (a32) and a synchronous positioning mechanism (a33) coordinated with the fixed positioning mechanism (a32), the fixed positioning mechanism (a32) includes a transverse positioning baffle (a34) and a longitudinal positioning baffle (a35) fixed on adjacent two sides of the positioning seat (a31), the synchronous positioning mechanism (a33) includes a transverse positioning pushing mechanism (a36) coordinated with the transverse positioning baffle (a34), a longitudinal positioning pushing mechanism (a37) coordinated with the longitudinal positioning baffle (a35), and a positioning driving mechanism (38) for driving the transverse positioning pushing mechanism (a36) and the longitudinal positioning pushing mechanism (a37) to move.

3. The film coating device for producing an implantable biosensor according to claim 1, characterized in that: The membrane liquid storage mechanism (a5) comprises a membrane liquid pool (a51) and a membrane liquid cover hingedly connected to the membrane liquid pool (a51).

4. The coating device for producing an implantable biosensor according to claim 3, characterized in that: A cleaning mechanism (a7) is fixed in the coating chamber (a2), and the cleaning mechanism (a7) includes a stirring and cleaning pool (a71) and an air blowing pool (a72) arranged and fixed with the film liquid pool (a51).

5. The film coating device for producing an implantable biosensor according to claim 1, characterized in that: The coating chamber (a2) is fixed with a material storage mechanism (a8), and the material storage mechanism (a8) includes a movable material storage base (a81) and a material driving mechanism (a82) that drives the material storage base (a81) to move out of or into the coating chamber (a2), and a material storage bin (a83) and a material discharge bin (a84) are formed on the material storage base (a81).

6. The film coating device for producing an implantable biosensor according to claim 1, characterized in that: The coating mechanism (a4) includes a coating component placement groove (a43) for placing and cleaning the coating component (a41), and the coating component placement groove (a43) is provided with multiple groups of card slots (a44) that cooperate with the installation card block (10).

7. The film coating device for producing an implantable biosensor according to claim 2, characterized in that: The transverse positioning pushing mechanism (a36) includes a transverse connecting block (a361) fixed to the positioning drive mechanism (38), a transverse pushing plate (a362) hingedly connected to the transverse connecting block (a361), and a transverse pushing wheel (a363) rotatably connected to the transverse pushing plate (a362). The longitudinal positioning pushing mechanism (a37) includes a longitudinal connecting block (a371) fixed to the positioning drive mechanism (38), a longitudinal pushing plate (a372) hingedly connected to the longitudinal connecting block (a371), and a longitudinal pushing wheel (a373) rotatably connected to the longitudinal pushing plate (a372).

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