A vacuum centrifugal degassing container, degassing device and degassing method

Abstract

The present invention discloses a vacuum centrifugal degassing container, a degassing device and a degassing method, comprising a barrel body, a piston is slidably arranged in the barrel body, a second joint and a third joint are connected to the barrel body, an isolation valve is arranged on the piston, the second joint is arranged above the piston, and the third joint is arranged below the piston. The isolation valve controls its own on-off by the pressure on the upper and lower sides of the piston, the second joint is exhausted by vacuuming, and the second joint is connected to compressed air to drive the piston downward, and a filter is arranged in the second joint. Compared with the prior art, the present invention realizes the aseptic property of vacuum centrifugal degassing by arranging a filter in the second joint. Secondly, by driving the piston downward to discharge materials by pressurization, the deadweight of the barrel body can be effectively reduced, and the structure on the barrel body is also simpler. Thirdly, a partition valve is arranged on the piston. When pressurized, the liquid medicine and air below the piston cannot flow to the top of the piston, which is conducive to draining the liquid medicine and later cleaning. Fourthly, it can be connected to the filling system.

Description

Technical Field

[0001] The invention relates to the technical field of material degassing, and in particular to a vacuum centrifugal degassing container, a degassing device and a degassing method. Background Art

[0002] The degassing effect of high-viscosity liquid medicine directly affects the quality of vacuum filling and vacuum plugging. The main high-viscosity degassing technologies now include: static vacuum degassing, centrifugal vacuum degassing and stirring vacuum degassing. Among them, centrifugal vacuum degassing technology has the highest efficiency and the best effect. Centrifugal vacuum degassing is to generate centrifugal force through high-speed rotation of the container under vacuum environment, so that the liquid flows in the container and releases the bubbles inside the liquid to achieve the degassing effect. At present, the vacuum centrifugal degassing machine is equipped with an open container. For example, the patent with publication number CN212651393U discloses a new type of self-rotation and revolving degassing mixer, in which a stirring vacuum barrel is installed on the upper end of the vacuum barrel mounting seat of the frame, and a stirring component is embedded in the vacuum barrel accommodating cavity of the stirring vacuum barrel; a vacuum pump is installed on the outside of the stirring vacuum barrel, a vacuum extraction pipeline of the vacuum pump is equipped with a suction filter component, and an exhaust pipeline of the vacuum pump is equipped with an exhaust filter component; the stirring component includes a movable turntable, a bearing seat, a driving shaft, a turntable linkage shaft, a flange shaft, and a shaft driving mechanism, the flange part of the flange shaft is screwed with the stirring barrel, and the shaft part of the flange shaft is equipped with a self-rotating driven spiral bevel gear; the turntable linkage shaft is equipped with a driven helical gear and a self-rotating active spiral bevel gear, the driven helical gear is meshed with the active helical gear at the upper end of the driving shaft, and the self-rotating active spiral bevel gear is meshed with the self-rotating driven spiral bevel gear. The degassing mixer in this patent cannot be used directly in the filling system. The liquid needs to be transferred to a special container before it can be used in the filling system. Therefore, the current technology can only be used for degassing treatment under conventional, non-sterile conditions, and cannot guarantee aseptic production. It cannot be used in aseptic processes, which directly restricts the filling and stoppering quality of high-viscosity liquid medicines. Summary of the invention

[0003] The invention provides a vacuum centrifugal degassing container, a degassing device and a degassing method, which are used to solve the problem that the prior art cannot perform aseptic degassing on a high-viscosity medicinal liquid.

[0004] The present invention provides a vacuum centrifugal degassing container, comprising a barrel body, a piston slidably arranged in the barrel body, a second joint and a third joint connected to the barrel body, an isolation valve is provided on the piston, the second joint is arranged above the piston, and the third joint is arranged below the piston. The isolation valve controls its own on-off by the pressure on the upper and lower sides of the piston, the second joint is exhausted by vacuuming, and the second joint is connected to compressed air to drive the piston downward, and a filter is provided in the second joint.

[0005] Preferably, the barrel body is provided with an exhaust valve and a first joint, the exhaust valve and the second joint are detachably connected, the exhaust valve is opened when the second joint is connected to the exhaust valve, and the exhaust valve is closed when the second joint is separated from the exhaust valve.

[0006] Preferably, the isolation valve includes a pressure plate and a first spring, the piston is provided with a first air vent, the first air vent is divided into three sections from top to bottom, the aperture of the middle section of the first air vent is larger than the apertures of the other two sections, the pressure plate and the first spring are both arranged in the middle section of the first air vent, the first spring is arranged at the upper end of the pressure plate, and the pressure plate moves up and down along the middle section of the first air vent.

[0007] Preferably, the isolation valve further comprises a sealing ring arranged at the middle section of the first vent hole, and the sealing ring is arranged at the lower end of the pressure plate.

[0008] Preferably, the exhaust valve includes: a valve body, a valve core and a second spring, the valve body is provided with a second air vent, the second air vent is divided into three sections from top to bottom, the aperture of the middle section of the second air vent is larger than the apertures of the other two sections, the valve core and the second spring are both arranged in the middle section of the second air vent, the second spring is arranged at the lower end of the valve core, and the valve core moves up and down along the middle section of the second air vent.

[0009] Preferably, a push rod is provided at the lower end of the second joint, and the push rod passes through the upper section of the second vent hole to drive the valve core to move downward to open the exhaust valve. The upper end of the valve core is formed with an upwardly protruding arc surface, and the lower end of the push rod is formed with a limiting groove matched with the arc surface.

[0010] Preferably, an air guide channel connected to the middle section of the second air vent is formed in the valve core and the second joint, and the filter is arranged in the air guide channel of the second joint.

[0011] Preferably, the third connector is connected to a fourth connector and a fifth connector respectively, and the first connector, the fourth connector and the fifth connector are all sterile connectors.

[0012] The present invention also provides a degassing device, comprising the vacuum centrifugal degassing container as described above, the degassing device also comprising: a vacuum chamber, a revolution transmission mechanism and a rotation transmission mechanism, the revolution transmission mechanism, the rotation transmission mechanism and the vacuum centrifugal degassing container are all arranged in the vacuum chamber, the vacuum centrifugal degassing container is rotatably arranged on a support frame, the revolution transmission mechanism is fixedly connected to the support frame, the rotation transmission mechanism drives the vacuum centrifugal degassing container to rotate, and the vacuum chamber is connected to a vacuum extraction interface.

[0013] The present invention also provides a vacuum centrifugal degassing method, comprising the following steps:

[0014] Open the vacuum cavity, open the exhaust valve of the barrel in the vacuum cavity, the barrel is ventilated with air through the filter and the vacuum cavity, the liquid medicine is connected to the barrel through the joint on the barrel, and after the liquid medicine is filled, the vacuum cavity is closed.

[0015] The revolution transmission mechanism and the rotation transmission mechanism are started, and the barrel body rotates around the axis of the revolution transmission mechanism, and at the same time, the barrel body rotates around its own axis; the vacuum chamber is evacuated, and the isolation valve on the piston in the barrel body automatically opens under negative pressure, and the gas in the barrel body is discharged through the exhaust valve, and the barrel body is divided into an upper chamber and a lower chamber along the piston;

[0016] After the degassing of the medicine liquid is completed, the vacuum chamber stops evacuating, the vacuum chamber is opened, the isolation valve is automatically closed, the exhaust valve is closed, and the upper chamber is connected to compressed air to drive the piston downward. The downward pressure of the piston drives the medicine liquid in the lower chamber to be discharged along the joint at the bottom of the barrel.

[0017] Compared with the prior art, the present invention has the following beneficial effects:

[0018] First, by arranging a filter in the second joint, the sterility of the barrel can be ensured before, during and after vacuuming, thereby achieving the sterility of vacuum centrifugal degassing.

[0019] Second, the piston is driven downward by pressurization, which is beneficial to the pressurized discharge of high-viscosity liquids, and the liquid on the barrel wall can be scraped clean. Secondly, compared with the method of using an electric push rod to push the piston downward, the air pressurization method of the present invention can effectively reduce the dead weight of the barrel, which can increase the weight of the liquid medicine in the barrel, and also make the structure on the barrel simpler. Third, a shut-off valve is provided on the piston to ensure that the gas can be discharged normally when vacuuming; when pressurized, the liquid medicine and air below the piston cannot flow to the top of the piston, which is beneficial to drain the liquid medicine and subsequent cleaning.

[0020] Third, the barrel is equipped with a sterile docking port, which allows the defoamed liquid to be directly connected to the filling system without the need for secondary transfer, ensuring the sterile transfer of the liquid medicine. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] In order to more clearly illustrate the technical solutions in the present invention or the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0022] Figure 1 It is a schematic structural diagram of the degassing device of the present invention;

[0023] Figure 2 Schematic structural diagram of the vacuum centrifugal degassing container of the present invention during degassing;

[0024] Figure 3 Schematic structural diagram of the vacuum centrifugal degassing container of the present invention during liquid discharge;

[0025] Figure 4 Schematic structural diagram of the present invention when the exhaust valve is opened;

[0026] Figure 5 Schematic structural diagram of the present invention when the exhaust valve is closed;

[0027] Figure 6 Schematic structural diagram of the present invention when the isolation valve is closed;

[0028] Figure 7 Schematic structural diagram of the present invention when the isolation valve is opened.

[0029] Reference numerals:

[0030] 1. Barrel body, 2. Piston, 3. Isolation valve, 4. Exhaust valve, 5. First joint, 6. Third joint, 7. Second joint, 8. Filter, 9. Discharge head, 21. First ventilation hole, 31. Pressure plate, 32. First spring, 33. Sealing ring, 41. Valve body, 42. Valve core, 43. Second spring, 71. Push rod, 421. Arc surface, 711. Limit groove, 100. Air guide channel, 200. Fourth joint, 300. Fifth joint, 1000. Vacuum cavity, 2000. Revolution drive mechanism, 3000. Rotation drive mechanism, 4000. Support frame, 5000. Vacuum centrifugal degassing container, 6000. Vacuum pumping interface. Detailed implementation manners

[0031] In order to make the objectives, technical solutions and advantages of the present invention clearer, the technical solutions in the present invention will be clearly and completely described below with reference to the accompanying drawings in the present invention. Obviously, the described embodiments are some but not all of the embodiments of the present invention. All other embodiments obtained by those of ordinary skill in the art based on the embodiments in the present invention without making creative efforts shall fall within the protection scope of the present invention.

[0032] Refer to the attached Figure 2-3, this embodiment provides a vacuum centrifugal degassing container 5000, including a barrel body 1, a piston 2 is slidably arranged in the barrel body 1, the piston 2 divides the barrel body 1 into an upper cavity and a lower cavity, the barrel body 1 is connected with a second joint 7 and a third joint 6, an isolation valve 3 is provided on the piston 2, the second joint 7 is arranged above the piston 2, and the third joint 6 is arranged below the piston 2, the isolation valve 3 controls its own on-off by the pressure on the upper and lower sides of the piston 2, the second joint 7 exhausts by vacuuming, the second joint 7 is connected to compressed air to drive the piston 2 downward, and a filter 8 is arranged in the second joint 7. The vacuum centrifugal degassing container 5000 is placed in a vacuum chamber 1000, and the vacuum chamber 1000 is vacuumed. The upper cavity of the barrel body 1 can be vacuumed through the second joint 7. At this time, the pressure of the lower cavity is greater than the pressure of the upper cavity, the isolation valve 3 automatically opens, and the air in the lower cavity enters the upper cavity through the isolation valve 3, and then is discharged through the second joint 7. After the degassing of the medicine liquid is completed, the vacuum chamber 1000 is opened, and the external air enters the upper chamber. At this time, the pressure of the upper chamber is greater than that of the lower chamber, the isolation valve 3 is automatically closed, and the second joint 7 is connected to compressed air. The pressure of the upper chamber continues to increase, driving the piston 2 to move downward, and the piston 2 drives the medicine liquid in the lower chamber to be discharged from the third joint 6. The medicine liquid in the third joint 6 can directly enter the filling system through the pipeline without secondary transfer to ensure the aseptic transfer of the medicine liquid.

[0033] In another embodiment of the present invention: Figure 2 The barrel body 1 is provided with an exhaust valve 4 and a first joint 5. The exhaust valve 4 is detachably connected to the second joint 7. The exhaust valve 4 is opened when the second joint 7 is connected to the exhaust valve 4, and the exhaust valve 4 is closed when the second joint 7 is separated from the exhaust valve 4. The second joint 7 is installed on the exhaust valve 4, the exhaust valve 4 is opened, and then the vacuum chamber 1000 is vacuumed to degas the liquid in the lower chamber. After the degassing is completed, the vacuum state is released, the isolation valve 3 is automatically closed, the second joint 7 is removed, the exhaust valve 4 is automatically closed, and then the first joint 5 is connected to external compressed air for drainage. Since the piston 2 needs to be pushed downward, the upper chamber will be pressurized to a large extent. Under this pressure, if a filter 8 is used in the pipeline, the filter 8 is easily damaged.

[0034] In another embodiment of the present invention: an exhaust valve 4 and a first joint 5 are provided on the barrel body 1, and the exhaust valve 4 is opened when the second joint 7 is connected to the exhaust valve 4, and the exhaust valve 4 is closed when the second joint 7 is separated from the exhaust valve 4. The exhaust valve 4 is opened when the first joint 5 is connected to the exhaust valve 4, and the exhaust valve 4 is closed when the first joint 5 is separated from the exhaust valve 4. The structure of the first joint 5 is different from that of the second joint 7 in that there is no filter 8 in the first joint 5. The second joint 7 is installed on the exhaust valve 4, the exhaust valve 4 is opened, and then the vacuum chamber 1000 performs a vacuum operation to degas the liquid in the lower chamber. After the degassing is completed, the vacuum state is released, the isolation valve 3 is automatically closed, the second joint 7 is removed, and then the first joint 5 is installed on the exhaust valve 4, and the first joint 5 is connected to compressed air for drainage. This structural design also does not require the use of a filter 8 in the drainage operation.

[0035] See attached Figure 6-7 The isolation valve 3 includes a pressure plate 31 and a first spring 32. The piston 2 is provided with a first vent hole 21. The first vent hole 21 is divided into three sections from top to bottom. The aperture of the middle section of the first vent hole 21 is larger than the apertures of the other two sections. The pressure plate 31 and the first spring 32 are both arranged in the middle section of the first vent hole 21. The first spring 32 is arranged at the upper end of the pressure plate 31. The pressure plate 31 moves up and down along the middle section of the first vent hole 21.

[0036] The isolation valve 3 further includes a sealing ring 33 disposed in the middle section of the first vent hole 21 . The sealing ring 33 is disposed at the lower end of the pressing plate 31 .

[0037] Specifically, the upper cover is threadedly connected to the first vent hole 21, and the upper cover is provided with a vent hole connecting the second vent hole and the upper cavity of the barrel body 1, and the upper end of the first spring 32 is connected to the upper cover. The upper cover is opened, and the sealing ring 33, the pressing plate 31 and the first spring 32 are sequentially installed into the second vent hole, and then the upper cover is tightened to complete the assembly of the isolation valve 3.

[0038] See attached Figure 5-6 The exhaust valve 4 includes: a valve body 41, a valve core 42 and a second spring 43. The valve body 41 is provided with a second vent hole. The second vent hole is divided into three sections from top to bottom. The aperture of the middle section of the second vent hole is larger than the apertures of the other two sections. The valve core 42 and the second spring 43 are both arranged in the middle section of the second vent hole. The second spring 43 is arranged at the lower end of the valve core 42. The valve core 42 moves up and down along the middle section of the second vent hole. Specifically, the valve body 41 includes a shell and an inner sleeve. The inner sleeve is threadedly connected to the shell. The second spring 43 is sleeved on the valve core 42, and then the valve core 42 is installed in the inner sleeve. At this time, the lower end of the second spring 43 is connected to the inner sleeve. The inner sleeve is tightened to complete the assembly of the exhaust valve 4. A sealing ring 33 is arranged between the inner sleeve and the shell. The inner sleeve is provided with a retaining ring on the inner side of the sealing ring 33. Through this design, the sealing ring 33 can be effectively prevented from shrinking inward when vacuuming.

[0039] A push rod 71 is provided at the lower end of the second joint 7. The push rod 71 passes through the upper section of the second vent hole to drive the valve core 42 to move downward to open the exhaust valve 4. The upper end of the valve core 42 is formed with an arc surface 421 protruding upward, and the lower end of the push rod 71 is formed with a limit groove 711 adapted to the arc surface 421. When the push rod 71 moves downward to drive the valve core 42 to move downward, a gap appears between the valve core 42 and the housing, and the exhaust valve 4 is opened. When the push rod 71 leaves the exhaust valve 4, under the action of the second spring 43, the valve core 42 is pressed against the housing, and the exhaust valve 4 is closed.

[0040] The valve core 42 and the second joint 7 are both provided with an air guide channel 100 connected to the middle section of the second vent hole, and the filter 8 is arranged in the air guide channel 100 of the second joint 7. Specifically, the second joint 7 includes: a housing and a filter seat, the filter seat is fixed to the upper end of the housing, a push rod 71 is arranged between the filter seat and the housing, the housing is threadedly connected to the shell, the air guide channel 100 passes through the filter seat and the push rod 71, the filter 8 is arranged in the filter seat, and a sealing ring 33 in contact with the shell is embedded in the push rod 71.

[0041] The third connector 6 is connected to the fourth connector 200 and the fifth connector 300 respectively. The first connector 5 , the fourth connector 200 and the fifth connector 300 are all sterile connectors, and the filter 8 is a sterile filter 8 .

[0042] A specific structure of the piston 2 is as follows: a discharge head 9 is fixed to the bottom of the piston 2, and the discharge head 9 will enter the third joint 6 when it moves downward, which is helpful for discharge. Secondly, the outer edge of the piston 2 extends upward, which can effectively increase the contact area with the barrel body 1, and can make the sliding of the piston 2 smoother during the process of pressurized downward movement. Thirdly, a sealing ring 33 in contact with the barrel body 1 is embedded in the piston 2.

[0043] Specifically, the barrel body 1 includes a barrel body and a barrel cover, and the barrel cover is fixed to the barrel body by buckles.

[0044] Refer to the attached Figure 1The present invention also provides a degassing device, including the vacuum centrifugal degassing container 5000 as described above, the degassing device also includes: a vacuum chamber 1000, a revolution transmission mechanism 2000 and a rotation transmission mechanism 3000, the revolution transmission mechanism 2000, the rotation transmission mechanism 3000 and the vacuum centrifugal degassing container 5000 are all arranged in the vacuum chamber 1000, the vacuum centrifugal degassing container 5000 is rotatably arranged on a support frame 4000, the revolution transmission mechanism 2000 is fixedly connected to the support frame 4000, the rotation transmission mechanism 3000 drives the vacuum centrifugal degassing container 5000 to rotate, and the vacuum chamber 1000 is connected to a vacuum pump interface 6000, and the vacuum pump interface 6000 is connected to a vacuum pump. Specifically, the upper end of the rotating shaft passes through the vacuum chamber 1000 and is fixedly connected to the revolution transmission mechanism 2000 and the rotation transmission mechanism 3000 respectively. The rotating shaft is rotatably connected to the vacuum chamber 1000. The lower end of the rotating shaft is connected to a motor. The rotating shaft drives the revolution transmission mechanism 2000 to rotate, thereby driving the vacuum centrifugal degassing container 5000 on the support frame 4000 to rotate around the rotating shaft. The rotation transmission mechanism 3000 includes a first bevel gear and a second bevel gear that mesh with each other. The first bevel gear and the second bevel gear are fixedly connected to the rotating shaft and the barrel body 1 respectively. The rotating shaft drives the first bevel gear to rotate and drives the second bevel gear to rotate. The rotation of the second bevel gear drives the barrel body 1 to rotate around the axis of the barrel body 1. As can be seen from the above, the rotating shaft drives the vacuum centrifugal degassing container 5000 to revolve and rotate through the revolution transmission mechanism 2000 and the rotation transmission mechanism 3000, thereby generating centrifugal force, causing the liquid to flow in the barrel body 1, and releasing the bubbles inside the liquid under a vacuum state to achieve a degassing effect.

[0045] The present invention also provides a vacuum centrifugal degassing method, which is preferably used in the above-mentioned degassing device, and comprises the following steps:

[0046] Step 1: Open the vacuum chamber 1000, connect the second joint 7 to the exhaust valve 4 to open the exhaust valve 4 automatically, connect the third joint 6 at the bottom of the barrel 1 to the fourth joint 200 and the fifth joint 300 respectively, connect the feed pipe to the fourth joint 200, and then pour the liquid medicine into the barrel 1 along the fourth joint 200. After the liquid medicine filling is completed, close the vacuum chamber 1000. After the second joint 7 is connected to the exhaust valve 4, the barrel 1 is connected to the vacuum chamber 1000. Before and after vacuuming, the air can move freely between the two, and the filter 8 in the second joint 7 will filter the air entering the barrel 1 to ensure the sterility of the barrel 1.

[0047] Step 2: The revolution transmission mechanism 2000 and the rotation transmission mechanism 3000 are started, the rotating shaft drives the revolution transmission mechanism 2000 to rotate, and the barrel body 1 rotates around the rotation shaft. At the same time, the rotating shaft transmits power to the barrel body 1 through the rotation transmission mechanism 3000, so that the barrel body 1 rotates around its own axis; the vacuum pump evacuates the vacuum chamber 1000 through the vacuum interface 6000, and the isolation valve 3 of the piston 2 automatically opens under negative pressure. The centrifugal force generated by the high-speed rotation of the barrel body 1 cooperates with the vacuuming, so that the bubbles in the liquid in the barrel body 1 can be released, and the gas in the barrel body 1 is discharged through the exhaust valve 4;

[0048] Step 3: After the degassing of the liquid medicine is completed, the vacuum pump stops vacuuming, the vacuum chamber 1000 is opened, the gas enters the upper chamber, the pressure of the upper chamber is greater than the pressure of the lower chamber, under the action of the first spring 32, the isolation valve 3 is automatically closed, the second joint 7 is removed to automatically close the exhaust valve 4, the first joint 5 is connected to the compressed air, the compressed air enters the upper chamber to drive the piston 2 to move downward, and the piston 2 presses down to drive the liquid medicine to be discharged along the fifth joint 300. In this process, the isolation valve 3 is in a closed state, and the liquid medicine in the lower chamber will not enter the upper chamber, so that the liquid medicine is discharged more thoroughly and it will be more convenient to clean it later. Secondly, while the liquid medicine in the lower chamber is discharged smoothly by pressing the piston 2 downward, the liquid on the inner wall of the barrel 1 can also be scraped clean to reduce residue. Third, the liquid medicine is discharged from the fifth joint 300 at the bottom of the barrel 1 by pressurization, and the liquid medicine in the fifth joint 300 can be directly connected to the filling system through the pipeline, without the need for secondary transfer, to ensure the aseptic transfer of the liquid medicine.

[0049] In the present invention, by arranging the filter 8 in the second joint 7, the sterility in the barrel body 1 can be ensured before, during and after vacuuming, thereby achieving the sterility of vacuum centrifugal degassing.

[0050] Secondly, the exhaust valve 4 and the second joint 7 are matched to each other, so that the gas in the barrel 1 can be discharged after the filter 8 is installed, and the exhaust port is automatically closed after the filter 8 is removed, thereby realizing the aseptic operation of the exhaust port.

[0051] Third, the piston 2 is driven downward by pressurization to facilitate the pressurized discharge of high-viscosity liquids, and the liquid on the wall of the barrel 1 can be scraped clean. Secondly, compared with the method of using an electric push rod to push the piston 2 downward, the air pressurization method of the present invention can effectively reduce the dead weight of the barrel 1, which can increase the weight of the liquid medicine in the barrel 1 and make the structure on the barrel 1 simpler. Third, a shut-off valve is provided on the piston 2 to ensure that the gas can be discharged normally when vacuuming; when pressurized, the liquid medicine and air below the piston 2 cannot flow to the top of the piston 2, which is conducive to draining the liquid medicine and subsequent cleaning.

[0052] Fourthly, the barrel body 1 is provided with a sterile docking port, which can directly connect the defoamed liquid to the filling system without secondary transfer, thereby ensuring the sterile transfer of the liquid medicine.

[0053] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit it. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or make equivalent replacements for some of the technical features therein. However, these modifications or replacements do not deviate the essence of the corresponding technical solutions from the spirit and scope of the technical solutions of the embodiments of the present invention.

Claims

1. A vacuum centrifugal degassing container, It is characterized in that The invention comprises a barrel body (1), a piston (2) is slidably arranged in the barrel body (1), the barrel body (1) is connected with a second joint (7) and a third joint (6), an isolation valve (3) is arranged on the piston (2), the second joint (7) is arranged above the piston (2), the third joint (6) is arranged below the piston (2), the second joint (7) is exhausted by vacuuming, the second joint (7) is connected to compressed air to drive the piston (2) downward, and a filter (8) is arranged in the second joint (7); when the chamber above the piston (2) is vacuumed, the isolation valve (3) opens, and when air enters the chamber above the piston (2), the isolation valve (3) closes, the isolation valve (3) comprises a pressure plate (31) and a first spring (32), the piston (2) is provided with a first vent hole (21), the first spring (32) is arranged at the upper end of the pressure plate (31), and the pressure plate (31) moves up and down along the middle section of the first vent hole (21).

2. The vacuum centrifugal degassing container according to claim 1, It is characterized in that The barrel body (1) is provided with an exhaust valve (4) and a first joint (5); the exhaust valve (4) is detachably connected to a second joint (7); when the second joint (7) is connected to the exhaust valve (4), the exhaust valve (4) is opened; when the second joint (7) is separated from the exhaust valve (4), the exhaust valve (4) is closed.

3. The vacuum centrifugal degassing container according to claim 1, It is characterized in that The aperture of the middle section of the first vent hole (21) is larger than the apertures of the upper and lower sections, and the pressing plate (31) and the first spring (32) are both arranged in the middle section of the first vent hole (21).

4. The vacuum centrifugal degassing container according to claim 3, It is characterized in that The isolation valve (3) further comprises a sealing ring (33) arranged at the middle section of the first vent hole (21), and the sealing ring (33) is arranged at the lower end of the pressure plate (31).

5. The vacuum centrifugal degassing container according to claim 2, It is characterized in that The exhaust valve (4) comprises: a valve body (41), a valve core (42) and a second spring (43); the valve body (41) is provided with a second vent hole; the second vent hole is divided into three sections from top to bottom; the aperture of the middle section of the second vent hole is larger than the apertures of the other two sections; the valve core (42) and the second spring (43) are both arranged in the middle section of the second vent hole; the second spring (43) is arranged at the lower end of the valve core (42); and the valve core (42) moves up and down along the middle section of the second vent hole.

6. The vacuum centrifugal degassing container according to claim 5, It is characterized in that A push rod (71) is provided at the lower end of the second joint (7), and the push rod (71) passes through the upper section of the second vent hole to drive the valve core (42) to move downward to open the exhaust valve (4), and an upwardly protruding arc surface (421) is formed at the upper end of the valve core (42), and a limiting groove (711) adapted to the arc surface (421) is formed at the lower end of the push rod (71).

7. The vacuum centrifugal degassing container according to claim 6, It is characterized in that An air guiding channel (100) communicating with the middle section of the second air vent is formed in both the valve core (42) and the second joint (7), and the filter (8) is arranged in the air guiding channel (100) of the second joint (7).

8. The vacuum centrifugal degassing container according to claim 2, characterized in that the third joint (6) is respectively connected with a fourth joint (200) and a fifth joint (300), and the first joint (5), the fourth joint (200) and the fifth joint (300) are all sterile joints.

9. A degassing device, characterized in that it includes the vacuum centrifugal degassing container according to any one of claims 1-8, and the degassing device further includes: a vacuum cavity (1000), a revolution transmission mechanism (2000) and a rotation transmission mechanism (3000). The revolution transmission mechanism (2000), the rotation transmission mechanism (3000) and the vacuum centrifugal degassing container (5000) are all arranged in the vacuum cavity (1000). The vacuum centrifugal degassing container (5000) is rotatably arranged on a support frame (4000). The revolution transmission mechanism (2000) is fixedly connected with the support frame (4000), the rotation transmission mechanism (3000) drives the vacuum centrifugal degassing container (5000) to rotate, and a vacuum pumping interface (6000) is communicated with the vacuum cavity (1000).

10. A vacuum centrifugal degassing method, characterized in that it adopts the degassing device according to claim 9, and includes the following steps: Open the vacuum cavity (1000), open the exhaust valve (4) of the inner barrel (1) of the vacuum cavity (1000). The barrel (1) communicates with the vacuum cavity (1000) through the filter (8). Connect the liquid medicine into the barrel (1) through the joint on the barrel (1). After the liquid medicine filling is completed, close the vacuum cavity (1000); Start the revolution transmission mechanism (2000) and the rotation transmission mechanism (3000). The barrel (1) rotates around the axis of the revolution transmission mechanism (2000). At the same time, the barrel (1) rotates around its own axis. Vacuumize the vacuum cavity (1000). The isolation valve (3) on the piston (2) in the barrel (1) automatically opens under negative pressure. The gas in the barrel (1) is discharged through the exhaust valve (4). The barrel (1) is divided into an upper cavity and a lower cavity along the piston (2); After the liquid medicine degassing is completed, stop vacuumizing the vacuum cavity (1000), open the vacuum cavity (1000), the isolation valve (3) automatically closes, close the exhaust valve (4), connect compressed air outside the upper cavity to drive the piston (2) to move downwards, and the piston (2) presses down to drive the liquid medicine in the lower cavity to be discharged along the joint at the bottom of the barrel (1).

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