An emulsion preparation apparatus

Abstract

This invention discloses an emulsion preparation apparatus, comprising: an outer cylinder, a disperser, an inner cylinder, an inner cylinder plunger assembly, an outer cylinder plunger assembly, and a cover. The outer cylinder has a liquid outlet; the disperser has a dispersion orifice group and is fixedly disposed within the outer cylinder; the inner cylinder is fixedly disposed on the disperser and concentrically arranged with the outer cylinder, and an outer cavity is formed between the outer wall of the inner cylinder and the inner wall of the outer cylinder, with the liquid outlet communicating with the outer cavity; the inner cylinder has an inner cavity, which communicates with the outer cavity through the dispersion orifice group; the inner cylinder plunger assembly is slidably inserted into the inner cavity; the outer cylinder plunger assembly is sleeved on the inner cylinder and slidably inserted into the outer cavity; and the cover is detachably assembled onto the liquid outlet. In use, by cross-pumping the inner and outer cylinder plunger assemblies, the liquid is fully emulsified in the inner and outer cavities to form a stable emulsion.

Description

Technical Field

[0001] This invention relates to the field of pharmaceutical preparation technology, and more specifically to an emulsion preparation apparatus. Background Technology

[0002] Transarterial embolization (TACE) is currently a relatively effective method for treating various vascular solid organ tumors. Iodized oil injected through the hepatic artery can be deposited and retained in the liver tumor tissue. Therefore, it is often used by interventional radiology physicians as a treatment method in the field of interventional radiology, mainly for the embolization treatment of liver tumors. This has become a classic method for interventional embolization treatment of liver cancer in Asian countries.

[0003] To improve the therapeutic effect of iodized oil, some technicians have attempted to prepare iodized oil emulsions by mixing it with an aqueous phase. This typically involves mixing iodized oil with hydrophilic drugs or hydrophilic embolic materials to prepare emulsion-type embolic materials. The method of preparing iodized oil emulsions using a three-way stopcock pump is mainly used for small-scale emulsion preparation and is frequently used in laboratories. This method mainly involves connecting two syringes to the two ends of the three-way stopcock (excluding the outlet). The syringes contain the solution to be emulsified, and the two syringes are then alternately pushed, causing the liquid to emulsify by flowing back and forth between the two syringes through the three-way stopcock. Because the syringes are simply inserted into the ends, manual pressing is required during emulsification to prevent the syringes from popping out of the ends. If a syringe pops out, the entire emulsification experiment must be restarted. Summary of the Invention

[0004] To address the above technical problems, the present invention aims to provide an emulsion preparation apparatus to facilitate emulsification experiments by technicians.

[0005] The following are the specific technical solutions of the present invention:

[0006] An emulsion preparation apparatus, comprising:

[0007] The outer cylinder has a liquid outlet;

[0008] A disperser having a group of dispersing holes and fixedly disposed inside the outer cylinder;

[0009] The inner cylinder is fixedly disposed on the disperser and is concentrically arranged with the outer cylinder. An outer cavity is formed between the outer wall of the inner cylinder and the inner wall of the outer cylinder, and the liquid outlet communicates with the outer cavity. The inner cylinder has an inner cavity, and the inner cavity communicates with the outer cavity through the dispersion hole group.

[0010] An inner cylinder plunger assembly is slidably inserted into the inner cavity;

[0011] An outer cylinder plunger assembly, sleeved on the inner cylinder portion and slidably inserted into the outer cavity; and

[0012] The cover is detachably assembled onto the liquid outlet.

[0013] In some embodiments, the dispersion pore group includes:

[0014] Main hole; and

[0015] Multiple branch holes are configured to communicate with the main hole;

[0016] The plurality of branch holes are radially distributed with the main hole as the center.

[0017] In some embodiments, the channels of the plurality of branch holes are axially inclined relative to the central axis of the main hole; and / or

[0018] The channels of the multiple branch holes are designed in an arc shape.

[0019] In some embodiments, the inner cylinder plunger assembly has an insertion portion for inserting into the main bore and sealing the main bore.

[0020] In some embodiments, the insertion part has a latch at its end, and a guide member is disposed in the main hole. The guide member is used to deform the latch and allow it to at least partially enter the branch hole.

[0021] In some embodiments, the inner cylinder plunger assembly has a first pressing component, and the inner cylinder portion is provided with a groove for engaging the first pressing component.

[0022] In some embodiments, the outer cylinder plunger assembly has a second piston having a through hole for the inner cylinder portion to pass through, and the second piston reciprocates along the inner cylinder portion in the outer cavity.

[0023] In some embodiments, the outer cylinder plunger assembly has a connecting member and a second pressing member and a third pressing member that are separate from each other. The connecting member is configured to selectively bridge the second pressing member and the third pressing member, and the connecting member is slidably connected to the second pressing member and the third pressing member.

[0024] In some embodiments, the cover has a cylindrical portion for insertion into the liquid outlet, with one end of the cylindrical portion located inside the outer cavity and the other end of the cylindrical portion fixed to the cover.

[0025] In some embodiments, the columnar portion is an elastic member.

[0026] The emulsion preparation apparatus provided by this invention mainly consists of an outer cylinder, a disperser, an inner cylinder, an inner cylinder plunger assembly, an outer cylinder plunger assembly, and a cover. Combining the above structural design features, when conducting emulsification experiments, it is only necessary to inject the liquid to be emulsified into the inner or outer cavity of the emulsion preparation apparatus, and then emulsify the liquid to be emulsified by cross-pumping the inner and outer cylinder plunger assemblies in the reciprocating process between the inner and outer cavities to obtain an emulsion. Attached Figure Description

[0027] To more clearly illustrate the technical solutions in the embodiments of the present invention, the accompanying drawings used in the description of the embodiments will be briefly introduced below. Obviously, the accompanying drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0028] Figure 1 This is a cross-sectional view of an emulsion preparation apparatus when the inner cavity is filled with liquid.

[0029] Figure 2 This is a cross-sectional view of an emulsion preparation apparatus when the outer cavity is filled with liquid.

[0030] Figure 3 yes Figure 1 A partial cross-sectional view of the emulsion preparation apparatus.

[0031] Figure 4 yes Figure 2 A partial cross-sectional view of the emulsion preparation apparatus.

[0032] Figure 5 This is a schematic diagram showing the distribution of the main holes and branch holes on the disperser of an emulsion preparation device.

[0033] Figure 6 This is a cross-sectional view of the outer cylinder plunger assembly of the emulsion preparation apparatus.

[0034] Figure 7 This is a cross-sectional view of the inner cylinder plunger assembly of the emulsion preparation apparatus.

[0035] Figure 8 This is a three-dimensional view of the second plunger rod of the emulsion preparation apparatus.

[0036] Figure 9 for Figure 6 Enlarged view inside the dashed circle.

[0037] In the picture:

[0038] 10. Outer cylinder; 11. Liquid outlet; 12. Insertion groove; 13. Outer cavity; 111. Cover; 112. Columnar part;

[0039] 20. Disperser; 21. Dispersing hole assembly; 211. Main hole; 212. Support hole; 213. Guide component;

[0040] 30. Inner cylinder section; 31. Inner cavity;

[0041] 40. Outer cylinder plunger assembly; 41. Through hole; 42. Slot; 43. Second pressing component; 44. Third pressing component; 45. Connecting component; 46. Second plunger rod; 47. Second piston; 451. Dovetail tenon; 431. Dovetail groove;

[0042] 50. Inner cylinder plunger assembly; 51. Insertion part; 52. First pressing component; 53. First piston rod; 54. First piston; 511. Clamping flap. Detailed Implementation

[0043] The technical solutions in the embodiments will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments, not all embodiments.

[0044] In the embodiments, it should be understood that the terms "middle," "upper," "lower," "top," "right side," "left end," "above," "back," "center," etc., indicating orientation or positional relationships are based on the orientation or positional relationships shown in the accompanying drawings and are only for ease of description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of the present invention. Unless otherwise defined, the technical or scientific terms used in this disclosure should have the ordinary meaning understood by one of ordinary skill in the art to which this disclosure pertains. The terms "first," "second," and similar words used in this disclosure do not indicate any order, quantity, or importance, but are only used to distinguish different components. Words such as "comprising" or "including" mean that the element or object preceding the word covers the element or object listed after the word and its equivalents, but does not exclude other elements or objects.

[0045] Furthermore, in the description of this invention, it should be noted that, unless otherwise explicitly specified and limited, terms such as installation, connection, and interconnection should be interpreted broadly. For example, they can refer to fixed connections, detachable connections, or integral connections; they can refer to mechanical connections or electrical connections; they can refer to direct connections or indirect connections through an intermediate medium; and they can refer to the internal communication between two components. Those skilled in the art can understand the specific meaning of the above terms in this invention based on the specific circumstances.

[0046] like Figures 1 to 9As shown, an emulsion preparation apparatus includes an outer cylinder 10, a disperser 20, an inner cylinder 30, an outer cylinder plunger assembly 40, and an inner cylinder plunger assembly 50; the outer cylinder 10 has a liquid outlet 11; the disperser 20 is fixedly disposed inside the outer cylinder 10 and has a dispersion hole group 21; the inner cylinder 30 is located inside the outer cylinder 10 and is configured to be fixed to the disperser 20 and form an inner cavity 31 for containing liquid.

[0047] like Figures 1 to 3 As shown, the disperser 20 and the inner cylinder 30 are configured to separate the interior of the outer cylinder 10, such that an outer cavity 13 is formed inside the outer cylinder 10. The inner cavity 31 and the outer cavity 13 are configured to communicate through the dispersion hole group 21, and the liquid outlet 11 communicates with the outer cavity 13.

[0048] The inner cylinder plunger assembly 50 is inserted into the inner cavity 31. For example... Figure 7 As shown, the inner cylinder plunger assembly 50 includes a first pressing component 52, a first piston rod 53 and a first piston 54. The first pressing component 52 is located at one end of the first piston rod 53, and the first piston 54 is located at the other end of the first piston rod 53. The first piston rod 53 is fixedly connected to the first pressing component 52 and the first piston 54 respectively.

[0049] like Figures 4 to 5 As shown, the dispersion orifice group 21 includes a main orifice 211 and four branch orifices 212; all four branch orifices 212 are connected to the main orifice 211; the four branch orifices 212 are radially distributed with the main orifice 211 as the center. More specifically, the channels of the four branch orifices 212 are all configured to be axially inclined relative to the central axis of the main orifice 211, and the channels of the four branch orifices 212 are all arc-shaped, so that the plugging agent discharged from the four branch orifices 212 forms a vortex in the outer cavity 13. When the inner cylinder plunger assembly 50 is pressed down along the inner cavity, the liquid in the inner cavity 31 is diverted from the main orifice 211 to the four branch orifices 212 and flows into the outer cavity 13. Due to the arc-shaped flow channel design of the four branch orifices 212, the plugging agent discharged into the outer cylinder 10 can form a vortex in the outer cavity 13, which can further improve the emulsion preparation effect.

[0050] like Figure 2 , 7 As shown, the first piston 54 has an insertion part 51, which is used to insert into the main hole 211 to seal the main hole 211. The insertion part 51 and the first piston 54 are integrally formed. By configuring the insertion part 51, it is possible to effectively prevent liquid from flowing back into the main hole 211.

[0051] like Figures 3 to 4As shown, the insertion part 51 has a retaining flap 511 at its end, and a guide component 213 is disposed inside the main hole 211. The guide component 213 and the disperser 20 are integrally formed. After the insertion part 51 is inserted into the main hole 211, the retaining flap 511 undergoes elastic deformation under the guidance of the guide component 213, causing the retaining flap 511 to deform and partially enter the branch hole 212. This can improve the stability of the inner cylinder plunger assembly 50 and prevent the inner cylinder plunger assembly 50 from regressing due to excessive pressure in the outer cavity 13 when pushing the inner cylinder plunger assembly 50. At the same time, it can also further prevent liquid from flowing back into the main hole 211 or the inner cavity 31.

[0052] like Figure 1 As shown in Figure 2, the inner cylinder 30 is provided with a groove 42 that matches the first pressing member 52. The groove 42 is used to hold the first pressing member 52. Pressing the first pressing member 52 pushes the inner cylinder plunger assembly 50 downward along the inner cavity until the liquid in the inner cavity 31 is emptied. After that, the first pressing member 52 can be locked in the groove 42, thereby improving the stability of the inner cylinder plunger assembly 50. Together with the action of the insertion part 51 and the locking flap 511, it can effectively prevent the inner cylinder plunger assembly 50 from regressing.

[0053] like Figure 6 , 8 As shown in Figure 9, the outer cylinder plunger assembly 40 includes a second pressing component 43, a third pressing component 44, a connecting component 45, a second plunger rod 46, and a second piston 47. The second pressing component 43 and the third pressing component 44 are separate from each other, and both the second pressing component 43 and the third pressing component 44 are integrally formed with the second plunger rod 46. Both the second pressing component 43 and the third pressing component 44 are slidably connected to the connecting component 45. Exemplarily, the bottom surface of the connecting component 45 is provided with a dovetail tenon 451, and the top surfaces of the second pressing component 43 and the third pressing component 44 are provided with dovetail grooves 431. The second pressing component 43, the third pressing component 44, and the connecting component 45 are slidably connected by the dovetail tenon and the dovetail groove.

[0054] The second piston 47 has a through hole 41 for the inner cylinder 30 to pass through. The second piston 47 is inserted into the outer cavity 13, and the second piston 47 cooperates with the outer wall of the inner cylinder 30 and the inner wall of the outer cylinder 10 to form a sealing structure. In use, the second piston 47 slides back and forth along the inner cylinder 30 in the outer cavity 13.

[0055] When the outer cylinder plunger assembly 40 completely pushes the liquid in the outer cavity 13 into the inner cavity 31, the second piston 47 of the outer cylinder plunger assembly 40 blocks the branch hole 212 of the dispersion hole group 21.

[0056] When the liquid in the inner cavity 31 is pushed into the outer cavity 13, the connecting part 45 can be bridged between the second pressing part 43 and the third pressing part 44, so that the user can press the outer cylinder plunger assembly 40.

[0057] When the liquid in the outer cavity 13 is pushed into the inner cavity 31, removing the connecting part 45 that bridges the second pressing part 43 and the third pressing part 44 reduces the impact of the connecting part 45 on the user when operating the first pressing part 52. This provides good overall flexibility and facilitates user operation of the outer cylinder plunger assembly 40 and the inner cylinder plunger assembly 50.

[0058] like Figures 1 to 4 As shown, a cover 111 is fitted onto the outlet 11. The cover 111 has a cylindrical portion 112 for insertion into the outlet 11, with one end of the cylindrical portion 112 inserted into the outer cavity 13 and the other end of the cylindrical portion 112 fixedly connected to the cover 111. By configuring the cylindrical portion 112 to fill the outlet 11, the situation where some liquid cannot be fully emulsified due to accumulation at the outlet 11 can be avoided. For example, the cylindrical portion 112 is an elastic member to enhance the sealing of the cover and prevent liquid in the outer cavity 13 from leaking out. In addition, the cylindrical portion 112 is also configured to press against the second piston 47, so that the second piston 47 is away from the inner bottom surface of the outer cylinder portion 10. Pressing the cylindrical portion 112 against the second piston 47, so that the second piston 47 is away from the inner bottom surface of the outer cylinder portion 10, makes it easier for the user to pull out the outer cylinder plunger assembly 40.

[0059] The method of using the emulsion preparation apparatus of this invention can be referred to the following steps:

[0060] (1) Press the inner cylinder plunger assembly and the outer cylinder plunger assembly to the bottom in sequence to completely expel the air from the inner and outer cavities;

[0061] (2) Immerse the outlet into the solution to be emulsified, and raise the outer cylinder plunger assembly so that the solution to be emulsified enters from the outlet.

[0062] (3) Cover the outlet with the cap, press the outer cylinder plunger assembly while lifting the inner cylinder plunger assembly, so that the liquid flows from the outer cavity into the inner cavity.

[0063] (4) Press the inner cylinder plunger assembly while lifting the outer cylinder plunger assembly, so that the liquid flows from the inner cavity into the outer cavity;

[0064] (5) Repeat steps (3) and (4) multiple times until an emulsion is formed.

[0065] In summary, the emulsion preparation apparatus provided in this embodiment of the invention mainly consists of an outer cylinder, a disperser, an inner cylinder, an inner cylinder plunger assembly, an outer cylinder plunger assembly, and a cover. During the emulsification experiment, the reciprocating injection of liquid causes the liquid to mix back and forth between the outer cavity 13 and the inner cavity 31. Combined with the structural features of the inner cavity 31, the outer cavity 13, and the dispersion hole group 21, a high-pressure environment is provided for emulsification, allowing the liquid to emulsify and form an emulsion within the emulsion preparation apparatus. Therefore, during the emulsification experiment, it is only necessary to inject the liquid to be emulsified into the inner or outer cavity of the emulsion preparation apparatus, and then, by cross-injecting the inner and outer cylinder plunger assemblies, the liquid to be emulsified can be emulsified during the reciprocating process between the inner and outer cavities to obtain an emulsion.

[0066] In the description of this specification, the references to terms such as "this embodiment," "some embodiments," "other embodiments," or "specific example," etc., refer to specific features, structures, materials, or characteristics described in connection with that embodiment or example, which are included in at least one embodiment or example of this application. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in a suitable manner in any one or more embodiments or examples. Moreover, without contradiction, those skilled in the art can combine and integrate the different embodiments or examples described in this specification, as well as the features of different embodiments or examples.

[0067] Although embodiments of this application have been shown and described above, the scope of protection of this invention is not limited thereto. Any variations or substitutions that can be conceived without inventive effort should be covered within the scope of protection of this invention. Unless expressly stated otherwise, no element, action or instruction used herein should be construed as critical or necessary.

Claims

1. An emulsion preparation apparatus, characterized in that, include: The outer cylinder has a liquid outlet; A disperser having a group of dispersing holes and fixedly disposed inside the outer cylinder; The inner cylinder is fixedly disposed on the disperser and is concentrically arranged with the outer cylinder. An outer cavity is formed between the outer wall of the inner cylinder and the inner wall of the outer cylinder, and the liquid outlet communicates with the outer cavity. The inner cylinder has an inner cavity, and the inner cavity communicates with the outer cavity through the dispersion hole group. An inner cylinder plunger assembly is slidably inserted into the inner cavity; An outer cylinder plunger assembly is sleeved on the inner cylinder portion and slidably inserted into the outer cavity; as well as The cover is detachably mounted on the liquid outlet. The dispersion pore group includes: main hole; as well as Multiple branch holes are configured to communicate with the main hole; The plurality of branch holes are radially distributed with the main hole as the center; The channels of the plurality of branch holes are axially inclined relative to the central axis of the main hole; and / or The channels of the multiple branch holes are designed in an arc shape; The inner cylinder plunger assembly has an insertion part for inserting into the main bore and sealing the main bore; The insertion part is provided with a locking flap at its end, and a guide component is disposed in the main hole. The guide component is used to deform the locking flap and allow it to enter the branch hole at least partially.

2. The emulsion preparation apparatus according to any one of claims 1, characterized in that, The inner cylinder plunger assembly has a first pressing component, and the inner cylinder portion is provided with a groove for locking the first pressing component.

3. The emulsion preparation apparatus according to any one of claims 1, characterized in that, The outer cylinder plunger assembly has a second piston with a through hole for the inner cylinder portion to pass through, and the second piston reciprocates along the inner cylinder portion in the outer cavity.

4. An emulsion preparation apparatus according to any one of claims 1, characterized in that, The outer cylinder plunger assembly has a connecting component and a second pressing component and a third pressing component that are separate from each other. The connecting component is configured to selectively bridge the second pressing component and the third pressing component, and the connecting component is slidably connected to the second pressing component and the third pressing component.

5. An emulsion preparation apparatus according to any one of claims 1, characterized in that, The cover has a columnar portion for inserting into the liquid outlet, with one end of the columnar portion located inside the outer cavity and the other end of the columnar portion fixed to the cover.

6. The emulsion preparation apparatus according to claim 5, characterized in that, The columnar portion is an elastic component.

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