A method for detecting water temperature and flow of a water distribution device for water bath sterilization of a large infusion product

Abstract

The application discloses a water distribution temperature and flow detection method for water bath sterilization equipment of large infusion products and belongs to the technical field of medicine bottle sterilization. The method comprises the following steps: arranging a water distribution temperature and flow detection system on a sterilization rack of a sterilization cabinet of the water distribution temperature and flow detection system of the water bath sterilization equipment; setting the cross-sectional area of a water quantity collection temperature detector to be the same as the maximum cross section of the medicine bottle, so as to ensure that the water quantity on the surface of the medicine bottle per unit time is collected, the number and position of the water quantity collection temperature detector are completely consistent with the number and position of the single-row medicine bottle, and the spatial position is overlapped; collecting circulating water flowing out of the holes of a water distribution plate by the water quantity collection temperature detector; emptying the air in a water flow guide pipe and a variable-diameter pipeline in sequence by the collected circulating water; measuring the temperature of the circulating water by a temperature probe arranged in the variable-diameter pipeline; and measuring the flow of the circulating water by an ultrasonic flow meter arranged at the end of the water flow guide pipe.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of vial sterilization, and more particularly to a water bath sterilization equipment water distribution temperature and flow detection method for large infusion products. BACKGROUND

[0002] Infusion is one of the most widely used and most important treatment methods in clinical application. The drug solution directly enters the blood through the human body's veins, and the sterility level of the drug solution is crucial to the safety of human medication. The sterility of large infusion is usually achieved by killing microorganisms, and the mainstream sterilization method adopted by the large infusion industry is heat sterilization.

[0003] The method of heating water by steam or other medium and killing microorganisms by "superheated water" under certain pressure is the most commonly used heat sterilization method. Due to the uniformity of water temperature, controllability of temperature, economy of medium and other factors, it has been widely used in the pharmaceutical industry. The method of killing microorganisms by "superheated water" is called water bath sterilization.

[0004] Water bath sterilization has an advantage over other sterilization methods in terms of temperature uniformity. In the actual vial sterilization process, this temperature uniformity is also relative. The vials sterilized by "superheated water" in the same sterilizer will also show different physical and chemical properties due to temperature differences. The main reason for these different properties is the uneven distribution of water volume and temperature.

[0005] This temperature difference has a particularly significant impact on the sterilization quality of heat-sensitive vials. Chinese patent "Water bath sterilization temperature and pressure uniform water distribution system" application number: CN202011372941.X only studies the water distribution temperature and pressure uniform water distribution system of water bath sterilization, but does not detect the flow and temperature of the water received by the vials at different positions.

[0006] Nowadays, dense probes are generally used to test whether the temperature of each point of the water bath sterilization cabinet is uniform. Generally, there is one probe for every cubic meter. This measurement is relatively rough and cannot be fine-tuned to the point where each vial is located. SUMMARY

[0007] The purpose of the present application is to provide a water bath sterilization equipment water distribution temperature and flow detection method for large infusion products, in order to solve the technical problems existing in the background art.

[0008] In order to achieve the above purpose, the present application adopts the following technical solutions:

[0009] A water bath sterilization equipment water distribution temperature and flow detection method for large infusion products, comprising the following steps:

[0010] The water distribution temperature and flow detection system is arranged on the sterilization rack of the sterilization cabinet of the water bath sterilization equipment water distribution temperature and flow detection system;

[0011] The cross-sectional area of the water quantity collection temperature detector is set to be the same as the maximum cross-section of the medicine bottle, ensuring that the water quantity per unit time flowing through the surface of the medicine bottle is collected, and the number and position of the water quantity collection temperature detectors are completely consistent with the number and position of the single-row medicine bottles, ensuring the overlap of the spatial positions;

[0012] The circulating water flowing out of the holes of the water distribution plate is collected by the water quantity collection temperature detector;

[0013] The collected circulating water is used to sequentially empty the air in the water flow guide pipe and the reducing pipe;

[0014] The temperature of the circulating water is measured by the temperature probe arranged in the reducing pipe;

[0015] The flow rate of the circulating water is measured by the ultrasonic flow meter arranged at the end of the water flow guide pipe.

[0016] In some embodiments, the water temperature of the sterilization cabinet needs to be set to a fixed temperature before detection, and the cycle is maintained.

[0017] In some embodiments, the circulating water flowing out of the holes of the water distribution plate is collected by the water quantity collection temperature detector; including, the water quantity collection temperature detector collects the circulating water flowing out of the holes of the water distribution plate, and transmits the data to the control box through the data line.

[0018] In some embodiments, the flow rate of the circulating water is measured by the ultrasonic flow meter arranged at the end of the water flow guide pipe; including, the circulating water flows through the reducing pipe, and then flows through the ultrasonic flow meter through the water flow guide pipe, and the flow rate data of the circulating water in the cabinet is transmitted to the control box through the data line of the ultrasonic flow meter.

[0019] In some embodiments, after the control box collects the data transmitted by the temperature probe and the ultrasonic flow meter, the data is collected at a frequency of once per second until the data before and after each water quantity collection temperature detector is basically stable, and then the measurement platform is controlled to move to the position of the next row of medicine bottles until the data collection of the last row of medicine bottles is completed.

[0020] In some embodiments, the water bath sterilization equipment water distribution temperature and flow detection system comprises:

[0021] A sterilizer, wherein a sterilization cavity is arranged in the sterilizer;

[0022] A sterilization rack, which is slidingly arranged in the sterilization cavity;

[0023] A water distribution system, which is arranged above the sterilization cavity and is used for spraying sterilization on the products on the sterilization rack;

[0024] A circulating water constant pressure system is installed above the sterilizer and connected to the water distribution system.

[0025] A temperature uniformization device is installed in a circulating water constant pressure system;

[0026] The water distribution temperature and flow rate detection system is installed inside the sterilization rack and located below the water distribution system. It is used to detect the flow rate and temperature of the water in the sterilization chamber.

[0027] In some embodiments, the water distribution temperature and flow rate detection system includes:

[0028] A water measurement platform, which is installed on a sterilization rack;

[0029] The measuring platform is slidably connected to the measuring water platform;

[0030] A water collection and temperature measuring device, multiple of which are mounted on a measuring platform; located below the water distribution system;

[0031] The water collection and temperature measuring device includes:

[0032] A support column, wherein the support column has a hollow mounting cavity;

[0033] An open funnel is disposed within the mounting cavity;

[0034] A liquid collecting pipe is disposed within the mounting cavity, and the top of the liquid collecting pipe is sealed to the bottom of the open funnel.

[0035] A reducing pipe is provided, wherein the reducing pipe is disposed in the installation cavity and the top of the reducing pipe is sealed to the bottom of the liquid collecting pipe;

[0036] A water flow conduit, wherein the water flow conduit is sealed to the lower part of a reducing pipe;

[0037] An ultrasonic flow meter, wherein the ultrasonic flow meter is connected to a water flow conduit;

[0038] A temperature probe, one end of which is installed inside the liquid collecting tube and the other end of which is installed outside the support column;

[0039] A control box, which is communicatively connected to both a temperature probe and an ultrasonic flow meter;

[0040] Among them, the bottom diameter of the open funnel is greater than the bottom diameter of the collecting pipe, which is greater than the bottom diameter of the reducing pipe.

[0041] In some embodiments, the measuring platform is slidably connected to the measuring water platform by a control component, the control component comprising a servo motor, a synchronous belt, a moving balance guide rod, and a synchronous belt bushing wheel, one end of the synchronous belt being sleeved on an output end of the servo motor, the other end of the synchronous belt being sleeved on the synchronous belt bushing wheel installed on the measuring water platform, the moving balance guide rod being arranged on the measuring water platform, the measuring platform being slidably sleeved on the moving balance guide rod; and the synchronous belt being fixedly connected with the measuring platform.

[0042] In some embodiments, the water bath sterilization temperature and pressure uniform water distribution system further comprises a heating heat exchange device and a refrigeration heat exchange device respectively communicating with the temperature uniform device.

[0043] The water distribution system comprises:

[0044] The cabinet constant pressure pipe is in communication with a water outlet end of the circulating water constant pressure system.

[0045] The shunt pipes are connected to the cabinet constant pressure pipe at equal intervals.

[0046] The water distribution disc is arranged at the top of the sterilization cavity, and each water distribution disc is provided with a water storage cavity, a plurality of first water leakage holes are arranged at the bottom of the water storage cavity, and each water distribution disc is provided with a shunt pipe.

[0047] The retaining ring is arranged at the bottom of the water storage cavity, and the shunt pipe is arranged in the retaining ring.

[0048] In some embodiments, the shunt pipe is in a U shape, the middle part of the shunt pipe is connected to the cabinet constant pressure pipe, two retaining rings are arranged on each water distribution disc, the two ends of the U-shaped shunt pipe are arranged in the retaining rings respectively, and flow regulating fluted discs are arranged at the two ends of the shunt pipe respectively.

[0049] In some embodiments, the circulating water constant pressure system comprises:

[0050] The balance pipe is in communication with the water outlet of the temperature uniform device.

[0051] The constant pressure tank is in communication with the outlet of the balance pipe.

[0052] The out-of-cabinet constant pressure pipe is connected with the water outlet of the constant pressure tank, and is connected with the in-cabinet constant pressure pipe through a connecting pipe which is sealingly and fixedly arranged on the side wall of the sterilizer; the heating and heat exchanging device comprises a heating and heat exchanging device and a first water pump, the water inlet end of the first water pump is communicated with the bottom of the sterilizer, the water outlet end of the first water pump is communicated with the water inlet of the heating and heat exchanging device, and the water outlet of the heating and heat exchanging device is connected with the water inlet end of the mixed water pipe; the sterilization frame comprises a plurality of layers of stacked sterilization boxes, the sterilization box is provided with a placing cavity, the bottom of the sterilization box is provided with a hollow interlayer, a plurality of second water leakage holes are formed in the top wall of the hollow interlayer, a plurality of third water leakage holes are formed in the bottom wall of the hollow interlayer, and the diameter of the second water leakage hole is larger than that of the third water leakage hole.

[0053] Compared with the prior art, the present application has the following beneficial effects:

[0054] By applying the method of the present application, the shape and position of the water flow collection temperature measuring device transverse section are consistent with the position of the medicine in the cabinet, ensuring that the water flow flowing through the medicine at the same time is consistent with the water flow flowing into the water flow collection temperature measuring device. The water flow flowing into the water flow collector is collected at the variable diameter pipeline after passing through the open leak head and flows through the A-level temperature probe to complete the temperature measurement in time. The sterilization cabinet circulating water after temperature measurement flows through the water flow guide pipe and flows through the ultrasonic flow meter to complete the water flow measurement per unit time. After the collection time set by the program, move one bottle interval to measure the water flow and temperature flowing through the second row of bottles, and move back and forth until the detection of all bottle positions is completed.

[0055] In this way, under the same measurement conditions, the water flow and temperature changes of multiple bottles flowing through the surface of the container per unit time can be accurately obtained through multiple water flow collectors and multiple ultrasonic flow meters.

[0056] By applying the detection method of the present application, the differences of water flow and temperature of the outer surfaces of the various bottles in the flow path are detected and indicated for the engineering technicians to adjust the water distribution points. Finally, the sterility level, physical and chemical properties of the same batch of medicines are consistent. BRIEF DESCRIPTION OF DRAWINGS

[0057] Figure 1 is a schematic diagram of a water distribution temperature flow detection equipment of a water bath sterilization equipment for large infusion products of the present application.

[0058] Figure 2 is a structural schematic diagram of a sterilization cavity of the present application.

[0059] Figure 3 is a connection schematic diagram of a water distribution system and a circulating water constant pressure system of the present application.

[0060] Figure 4Figure 1 is a schematic diagram of the connection between the water distribution disc and the retaining ring of the present application.

[0061] Figure 5 Figure 2 is a schematic diagram of the connection between the water distribution disc and the shunt pipe of the present application.

[0062] Figure 6 Figure 3 is a schematic diagram of the connection between the flow regulating flower disc and the shunt pipe of the present application.

[0063] Figure 7 Figure 4 is a schematic diagram of the structure of the sterilization box of the present application.

[0064] Figure 8 Figure 5 is a schematic diagram of the structure of the water distribution temperature flow detection system of the present application.

[0065] Figure 9 Figure 6 is a schematic diagram of the structure of the water volume collection temperature detector of the present application.

[0066] Figure 1 is a schematic diagram of the connection between the water distribution disc and the retaining ring of the present application. DETAILED DESCRIPTION

[0067] In order to make the purpose, technical scheme and advantages of the present application more clear, the technical scheme in the embodiments of the present application will be described in more detail below in combination with the drawings in the preferred embodiments of the present application. In the drawings, the same or similar reference signs represent the same or similar components or components with the same or similar functions throughout. The described embodiments are part of the embodiments of the present application, not all the embodiments. The embodiments described below by referring to the drawings are exemplary and are intended to explain the present application, and cannot be understood as a limitation of the present application. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without making creative efforts fall within the scope of protection of the present application.

[0068] The embodiments of the present application will be described in detail below with reference to the drawings.

[0069] In the description of the present application, it should be noted that unless specifically defined and limited, the terms "mounting", "connection", "linking" should be understood in a broad sense, for example, it can be fixed connection, or indirect connection through intermediate medium, or internal communication of two elements or interaction relationship between two elements. For those skilled in the art, the specific meaning of the above terms in the present application can be understood according to the specific circumstances.

[0070] In the description of the present application, it should be understood that the terms "upper", "lower", "front", "rear", "vertical", "horizontal", "top", "bottom", "inner", "outer" and the like indicate the orientation or positional relationship based on the drawings, and are only for the convenience of describing the present application and simplifying the description, and do not indicate or imply that the device or element referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as a limitation on the present application.

[0071] In addition, the terms "including" and "having" and any variations thereof are intended to cover non-exclusive inclusion, for example, a process, method, system, product or display including a series of steps or units does not have to be limited to those steps or units clearly listed, but can include other steps or units not clearly listed or inherent to these processes, methods, products or displays.

[0072] The following will be described in detail Figures 1-9 A water distribution temperature and flow detection method for a large infusion product water bath sterilization equipment is described in detail. It should be noted that the following embodiments are only used to explain the present application and do not constitute a limitation on the present application.

[0073] Embodiment 1:

[0074] A water distribution temperature and flow detection method for a large infusion product water bath sterilization equipment is described in detail. It should be noted that the following embodiments are only used to explain the present application and do not constitute a limitation on the present application.

[0075] The water distribution temperature and flow detection system is arranged on the sterilization shelf of the sterilization cabinet of the water distribution temperature and flow detection system of the water bath sterilization equipment;

[0076] The cross-sectional area of the water quantity collection temperature detector is set to be the same as the maximum cross-sectional area of the medicine bottle, so as to ensure that the water quantity per unit time flowing through the surface of the medicine bottle is collected, and the number and position of the water quantity collection temperature detectors are completely consistent with the number and position of the single-row medicine bottles, so as to ensure the overlap of the spatial positions;

[0077] The circulating water flowing out of the holes of the water distribution plate is collected by the water quantity collection temperature detector;

[0078] The collected circulating water is used to sequentially empty the air in the water flow conduit and the reducing pipeline;

[0079] The temperature of the circulating water is measured by the temperature probe arranged in the reducing pipeline;

[0080] The flow of the circulating water is measured by the ultrasonic flowmeter arranged at the end of the water flow conduit.

[0081] In some embodiments, the water temperature of the sterilization cabinet is set to a fixed temperature before detection, and the temperature is kept circulating.

[0082] In some embodiments, the water quantity collection temperature collector is used to collect the circulating water flowing out of the holes of the water distribution plate; including, the water quantity collection temperature collector collects the circulating water flowing out of the holes of the water distribution plate, and transmits the data to the control box through the data line.

[0083] In some embodiments, the flow of the circulating water is measured by the ultrasonic flowmeter arranged at the end of the water flow conduit; including, the circulating water flows through the reducing pipeline, and then flows through the ultrasonic flowmeter through the water flow conduit, and the flow data of the circulating water in the cabinet is transmitted to the control box through the data line of the ultrasonic flowmeter.

[0084] In some embodiments, after the control box collects the data transmitted by the temperature probe and the ultrasonic flowmeter, the data is collected at a frequency of once per second until the data before and after each water quantity collection temperature collector is basically stable, and then the measurement platform is controlled to move to the position of the next row of medicine bottles until the data collection of the last row of medicine bottles is completed.

[0085] As shown in Figure 1 and 2 The water bath sterilization equipment water distribution temperature and flow detection equipment includes: a sterilizer 1, a sterilization cavity 15 is arranged in the sterilizer 1; a sterilization rack 16 is slidingly arranged in the sterilization cavity 15; a water distribution system is arranged above the sterilization cavity 15, and is used for spraying sterilization on the products on the sterilization rack 16; a circulating water constant pressure system is arranged above the sterilizer 1, and is connected with the water distribution system; a temperature uniform device is arranged on the circulating water constant pressure system; a water distribution temperature and flow detection system 26 is installed in the sterilization rack 16, and is located below the water distribution system, and is used for detecting the flow and temperature of the water in the sterilization cavity 15.

[0086] In some embodiments, the water distribution temperature flow detection system 26 comprises: a measuring water platform 38 installed on the sterilization rack 16; a measuring platform 36 slidingly connected to the measuring water platform 38; a plurality of water volume collection thermometers 27 arranged on the measuring platform 36 below the water distribution system. The measuring water platform 38 is provided with a position sensor 35 on one side.

[0087] The water volume collection thermometer 27 comprises: a support provided with a hollow installation cavity; an open funnel arranged in the installation cavity; a liquid collecting pipe 41 arranged in the installation cavity, and the top of the liquid collecting pipe 41 is sealingly connected with the lower part of the open funnel; a variable diameter pipe 43 arranged in the installation cavity, and the top of the variable diameter pipe 43 is sealingly connected with the lower part of the liquid collecting pipe 41; a water flow guide pipe 29 sealingly connected with the lower part of the variable diameter pipe 43; an ultrasonic flow meter 30 connected with the water flow guide pipe 29; a temperature probe 42 arranged in the liquid collecting pipe 41 at one end and arranged outside the support at the other end; a control box 39 communicatively connected with the temperature probe 42 and the ultrasonic flow meter 30, respectively; wherein the diameter of the bottom of the open funnel > the diameter of the bottom of the liquid collecting pipe 41 > the diameter of the bottom of the variable diameter pipe 43.

[0088] In some embodiments, the measuring platform 36 is slidingly connected to the measuring water platform 38 through a control component, which comprises a servo motor 31, a synchronous belt 33, a moving balance guide rod 37, and a synchronous belt 33 bushing wheel. One end of the synchronous belt 33 is sleeved on the driving wheel of the servo motor 31, and the other end of the synchronous belt 33 is sleeved on the synchronous belt 33 bushing wheel installed on the measuring water platform 38. The moving balance guide rod 37 is arranged on the measuring water platform 38, and the measuring platform 36 is slidingly sleeved on the moving balance guide rod 37. The synchronous belt 33 is fixedly connected with the measuring platform 36.

[0089] In some embodiments, the diameter of the open funnel is the same as the maximum cross section of the medicine bottle 17.

[0090] As Figures 1-3As shown, in this embodiment, the water distribution system includes: a constant pressure pipe 18 inside the cabinet, a diversion pipe 9, a water distribution tray 8, and a baffle ring 14. The constant pressure pipe 18 inside the cabinet is connected to the outlet of the circulating water constant pressure system. Multiple diversion pipes 9 are connected at equal intervals to the constant pressure pipe 18 inside the cabinet. Multiple water distribution trays 8 are disposed on the top of the sterilization chamber 15, and each water distribution tray 8 has a water storage chamber. Several first drainage holes 21 with a diameter of approximately 2 mm are provided at the bottom of the water storage chamber. Each water distribution tray 8 corresponds to one diversion pipe 9. The baffle ring 14 is disposed at the bottom of the water storage chamber, and the diversion pipes 9 are disposed within the baffle ring 14. The function of the baffle ring 14 is to prevent the circulating water from affecting the water level of the water distribution tray 8. At the geometric center of the water distribution tray 8, there are two retaining rings 14 with a height of 15-20mm and a diameter of 30mm. The retaining rings 14 are connected to the water distribution tray 8 by welding. The water distribution tray 8 is connected to the inner wall of the sterilization chamber 15 by a bracket. Preferably, the diversion pipe 9 is U-shaped, and the middle part of the diversion pipe 9 is connected to the constant pressure pipe 18 inside the cabinet. Each water distribution tray 8 is provided with two retaining rings 14. The two ends of the U-shaped diversion pipe 9 are respectively set in the retaining rings 14. Flow regulating discs 13 are respectively provided at the two ends of the diversion pipe 9.

[0091] Two flow regulating discs 13 can adjust the flow rate of the 9 diversion pipes by rotating relative to each other. The outlet of the diversion pipe 9 extends 5mm into the baffle ring 14. The upper end of the diversion pipe 9 is connected to the constant pressure pipe 18 inside the cabinet. The diversion pipes 9 are evenly distributed on the constant pressure pipe 18 inside the cabinet. The diameter of the constant pressure pipe 18 inside the cabinet is more than twice the diameter of the diversion pipe 9. The upper end of the constant pressure pipe 18 inside the cabinet is connected to the constant pressure pipe 5 outside the cabinet through the sterilization chamber 15. The diameter of the constant pressure pipe 5 outside the cabinet is about twice the diameter of the constant pressure pipe 18 inside the cabinet, and its length is about the same as that of the constant pressure pipe 18 inside the cabinet. The connection point between the constant pressure pipe 18 inside the cabinet and the constant pressure pipe 5 outside the cabinet is the geometric center of the constant pressure pipe 5 outside the cabinet.

[0092] like Figure 7 As shown, in this embodiment, the sterilization rack 16 includes: a plurality of stacked sterilization boxes 22, each sterilization box 22 having a placement cavity; the bottom of each sterilization box 22 has a hollow interlayer 25; the top wall of the hollow interlayer 25 has a plurality of through second drainage holes 23; and the bottom wall of the hollow interlayer 25 has a plurality of through third drainage holes 24. The diameter of the second drainage holes 23 is larger than the diameter of the third drainage holes 24. The height of the hollow interlayer 25 is approximately 8-12 mm, the diameter of the third drainage holes 24 is approximately 2 mm, and the diameter of the second drainage holes 23 is approximately 6-8 mm.

[0093] like Figures 4-6As shown, in the present embodiment, the circulating water constant pressure system comprises: a balance pipe 4, the inlet of which is communicated with the water outlet of the temperature uniform device; a constant pressure tank 3, the water inlet of which is communicated with the outlet of the balance pipe 4; an out-of-cabinet constant pressure pipe 5, the water outlet of the constant pressure tank 3 is connected with the out-of-cabinet constant pressure pipe 5, the out-of-cabinet constant pressure pipe 5 is connected with the in-cabinet constant pressure pipe 18 through a connecting pipe, and the connecting pipe is sealingly and fixedly arranged on the side wall of the sterilizer 1. The pipe diameter of the connecting pipe is equivalent to the pipe diameter of the out-of-cabinet constant pressure pipe 5. The balance pipe 4 and the constant pressure tank 3 are both provided with two parts, which are symmetrically arranged on the two sides of the temperature uniform device. The pipe diameter of the balance pipe 4 is gradually reduced from the end far away from the constant pressure tank 3 to the end close to the constant pressure tank 3.

[0094] The diameter of the constant pressure tank 3 is about 3-6 times of the diameter of the out-of-cabinet constant pressure pipe 5, and the height is about 4-5 times of the diameter of the out-of-cabinet constant pressure pipe 5. A temperature controller 10 is arranged on the constant pressure tank 3. The upper end of the constant pressure tank 3 is connected with the balance pipe 4. The balance pipe 4 is composed of three pipes with gradually reduced diameters. The constant pressure tank 3 is connected with the smallest end of the balance pipe 4. The three pipes with gradually reduced diameters have the following advantages: the gas in the circulating water is collected in the large pipe and then buffered in the middle pipe, so that the circulating water flowing into the small pipe has less gas. According to the formula of fluid flow, the flow Q in the pipe is equal to the effective cross-sectional area S of the pipe multiplied by the flow velocity V of the medium in the pipe. The flow Q in the pipe is in cubic meters per second, the effective cross-sectional area S of the pipe is in square meters, and the flow velocity V of the medium in the pipe is in meters per second. According to the formula, the pipe diameter is gradually reduced. In the case of a certain total circulating water volume, the pipe diameter of the circulating pipeline is reduced, and the flow per unit cross-sectional area is increased. The advantage is that the water pressure is constant (the circulating pump outputs stably), and the flow per unit time through the small pipe diameter of the balance pipe 4 is relatively consistent in the case that the flow of the mixed water pipe 12 flowing to the two balance pipes 4 is inconsistent.

[0095] In the present embodiment, the temperature uniform device comprises: temperature controllers 10, which are respectively arranged on the constant pressure tanks 3; temperature balancing devices 11, which are arranged on the balance pipes 4; and a mixed water pipe 12, the water outlet end of which is respectively communicated with the water inlets of the two balance pipes 4. The heating and heat exchange device comprises a heating and heat exchange device 2 and a first water pump 6. The water inlet end of the first water pump 6 is communicated with the bottom of the sterilizer 1. The water outlet end of the first water pump 6 is communicated with the water inlet of the heating and heat exchange device 2. The water outlet of the heating and heat exchange device 2 is connected with the water inlet end of the mixed water pipe 12. The refrigeration and heat exchange device comprises a refrigeration and heat exchange device 7 and a second water pump 20. The water inlet end of the second water pump 20 is communicated with the bottom of the sterilizer 1, preferably the lowest point of the bottom of the sterilizer 1. The water outlet end of the second water pump 20 is communicated with the water inlet of the refrigeration and heat exchange device 7. The water outlet of the refrigeration and heat exchange device 7 is connected with the water inlet end of the mixed water pipe 12.

[0096] The temperature balancing device 11 is wound in the middle section of the balancing pipe 4, and the temperature balancing device 11 is a double-wound cold (hot) exchange device; the largest pipe diameter end of the balancing pipe 4 is connected with the mixed water pipe 12, the diameter of the mixed water pipe 12 is 2 times of the largest pipe diameter of the balancing pipe 4, and the connecting position of the largest pipe diameter end of the balancing pipe 4 and the mixed water pipe 12 is located at 1 / 2 of the geometric size inside the mixed water pipe 12; the other end of the mixed water pipe 12 is connected with the cabinet water circulation pipe through a variable diameter, and the other end of the cabinet water circulation pipe is connected with the cabinet water heat exchanger. The cabinet water pipe is connected with the water inlet ends of the refrigeration heat exchanger 7 and the heating heat exchanger 2 respectively, the medium end of the refrigeration heat exchanger 7 is connected with cooling water, the medium end of the heating heat exchanger 2 is connected with steam, and the water outlet ends of the refrigeration heat exchanger 7 and the heating heat exchanger 2 are connected with the water inlet end of the mixed water pipe 12 through pipes.

[0097] When the sterilizer 1 is in the warming-up stage: the cabinet circulating water is pumped out along the cabinet circulating water pipe 19 by the first water pump 6 and the second water pump 20 in the arrow direction, enters the refrigeration heat exchanger 7 and the heating heat exchanger 2 respectively, the steam valve at the medium end of the heating heat exchanger 2 is opened, and the cabinet circulating water is heated by steam; the cooling water valve at the medium end of the refrigeration heat exchanger 7 is in a closed state, the refrigeration heat exchanger 7 is used as a bypass of the heating heat exchanger 2 in the warming-up stage, plays a role in balancing water temperature, and avoids that rapid warming-up of the cabinet circulating water leads to rapid pressure rise of the sterilization cavity 15, the pressure of the medicine bottle 17 is too large, and the medicine bottle 17 is deformed due to unbalanced pressure inside and outside the medicine bottle 17.

[0098] The cabinet circulating water flowing through the refrigeration heat exchanger 7 and the heating heat exchanger 2 is mixed in the mixed water pipe 12, so that the water temperature is relatively uniform, the mixed circulating water flows into the balancing pipe 4 in the arrow direction and then flows into the constant pressure tank 3, and the pipe diameter of the balancing pipe 4 from large to small ensures that the water flow and pressure flowing into the constant pressure tank 3 are relatively uniform; the temperature controller 10 is installed on the constant pressure tank 3, detects the temperature difference of the circulating water in multiple constant pressure tanks 3, and opens the temperature balancing device 11 arranged in the middle section of the balancing pipe 4 to add steam for fine adjustment of the temperature, so that the temperatures of the circulating water in multiple constant pressure tanks 3 are similar; the circulating water with similar temperature and pressure enters the cabinet external constant pressure pipe 5 for secondary constant pressure, then flows into the cabinet internal constant pressure pipe 18 for third constant pressure, and then flows into the water distribution disc 8 through the flow distribution pipe 9, and the slight flow difference of multiple water distribution discs 8 is realized through the flow adjusting disc 13 arranged at the outlet end of the water distribution pipe.

[0099] The circulating water flowing into the water distribution tray 8 is blocked by the blocking ring 14, and the water storage cavity of the water distribution tray 8 forms an equal water level, which aims to ensure that the water flowing out of each first water leakage hole 21 of the water distribution tray 8 is consistent; the blocking ring 14 blocks the influence of the circulating water on the equal water level of the water distribution tray 8; the heated circulating water flows through the first water leakage hole 21 uniformly distributed on the water distribution tray 8 to shower the medicine bottles 17 stored in the sterilization box 22, ensuring that each medicine bottle 17 is showered with circulating water of the same temperature and flow at the same time; the circulating water flowing through the surface of the first layer of medicine bottles 17 flows through the second water leakage hole 23 at the upper end of the sterilization box 22 to form an equal liquid level in the hollow interlayer 25, and then flows through the third water leakage hole 24 of the lower layer of the sterilization box 22 to shower the next layer of medicine bottles 17.

[0100] The sterilization and heat preservation stage has the same principle as the heating stage;

[0101] In the sterilization and cooling stage, the cooling water valve of the medium end of the heating heat exchanger 2 is opened, and the circulating water in the cabinet is cooled by the cooling water; the steam valve of the medium end of the heating heat exchanger is in a closed state, and the heating heat exchanger 2 is used as a bypass of the refrigeration heat exchanger 7 in the cooling stage, which plays a role in balancing the water temperature, avoiding the rapid cooling of the circulating water in the cabinet causing the deformation of the medicine bottles 17 due to the uneven pressure inside and outside the medicine bottles 17; at the same time, the temperature controller 10 detects the temperature difference of the circulating water in the multiple constant pressure tanks 3 and opens the temperature balancing device 11 set in the middle section of the balance pipe 4 to add cooling water for fine tuning of the temperature, so that the temperature of the circulating water in the multiple constant pressure tanks 3 is similar, and when the temperature is lower than 100℃, the temperature balancing device 11 stops working, and the rest of the working process is the same as the heating stage.

[0102] In the measurement stage, the water quantity collection temperature measuring device 27 consistent with the number and position of the medicine bottles 17 is fixed on the measurement platform 36, the measurement platform 36 is horizontal with the measurement water platform 38, and the measurement water platform 38 is horizontal with the sterilization box 22 in the sterilization cabinet.

[0103] The control box 39 controls the servo motor 31 to drive the servo motor 31 driving wheel, which drives the measurement platform 36 to move through the synchronous belt 33, and the measurement platform 36 slides on the moving balance guide rod 37 through the internal linear bearing. When the measurement platform 36 moves to the position sensor 35, the control box 39 gives an instruction to the servo motor 31, so that the measurement platform 36 moves to the physical position of the first row of medicine bottles 17.

[0104] The circulating water in the sterilization cabinet flows out from the holes of the water distribution tray 8 in the water distribution system, and when it flows through the water volume collection temperature detector 27, it is collected by the open funnel head 40 of the water volume collection temperature detector 27 and then converges at the liquid collecting pipe 41 inside the water volume collection temperature detector 27. Since the bottom diameter of the open funnel is > the bottom diameter of the liquid collecting pipe 41 > the bottom diameter of the reducing pipe 43, the circulating water converges at the liquid collecting pipe 41, and the A-level temperature probe 42 placed at this position timely collects the temperature of the circulating water in the cabinet, and the temperature data is transmitted to the control box 39 through the data line 28. Then the circulating water in the cabinet flows through the reducing pipe 43 inside the water volume collection temperature detector 27 again, and then flows through the ultrasonic flow meter 30 through the water flow guide pipe 29, and the flow data of the circulating water in the cabinet is transmitted to the control box 39 through the data line of the ultrasonic flow meter 30. Since the bottom diameter of the liquid collecting pipe 41 is > the bottom diameter of the reducing pipe 43, it can ensure that the air in the reducing pipe 43 and the water flow guide pipe 29 is discharged, and the accuracy of the measurement is ensured.

[0105] It should be noted that a certain balance time is required when detecting the data of the first row of medicine bottles 17 to avoid the measurement error caused by the influence of the temperature of the water volume collection temperature detector 27 itself on the circulating water in the cabinet. At the same time, the control box 39 starts timing after the measurement platform 36 reaches the measurement position, and calculates the time required for the circulating water in the cabinet to flow from the water volume collection temperature detector 27 to the ultrasonic flow meter 30. After the control box 39 collects the data transmitted by the A-level temperature probe 42 and the ultrasonic flow meter 30, it collects the data at a frequency of once per second until the data before and after each water volume collection temperature detector 27 is basically stable, and then controls the measurement platform 36 to move to the position of the next row of medicine bottles 17 until the data collection of the last row of medicine bottles 17 is completed.

[0106] After the data collection is completed, the control box 39 can output the temperature and water volume data of each water volume collection temperature detector 27 at each row, and thus the detection of the water distribution flow and temperature of the water bath sterilization equipment is completed. The technician adjusts the position according to the data difference analysis, and then repeats the test until the flow and temperature of each point are basically consistent.

[0107] The above only describes the preferred embodiments of the present application and is not used to limit the present application, and any modification, equivalent replacement and improvement made within the spirit and principle of the present application shall be included in the protection scope of the present application.

Claims

1. A method for detecting the temperature and flow rate of water distribution in a water bath sterilization apparatus for a large-volume infusion product, characterized by, It comprises the following steps: The water distribution temperature flow detection system is arranged on the sterilization rack of the sterilizer of the water bath sterilization equipment water distribution temperature flow detection system; The cross-sectional area of the water collection temperature collector is set to be the same as the maximum cross-section of the medicine bottle, ensuring that the water flow per unit time on the surface of the medicine bottle is collected, and the number and position of the water collection temperature collectors are completely consistent with the number and position of the single-row medicine bottles, ensuring the overlap of the spatial positions; The circulating water flowing out of the holes of the water distribution plate is collected by the water collection temperature collector; The collected circulating water is used to sequentially empty the air in the water flow guide pipe and the variable-diameter pipeline; The temperature of the circulating water is measured by the temperature probe arranged in the liquid collecting pipe; The flow of the circulating water is measured by the ultrasonic flow meter arranged at the end of the water flow guide pipe; The water bath sterilization equipment water distribution temperature flow detection system comprises: A sterilizer, wherein a sterilization cavity is arranged in the sterilizer; A sterilization rack, wherein the sterilization rack is slidingly arranged in the sterilization cavity; A water distribution system, which is arranged above the sterilization cavity and is used for spraying sterilization on the products on the sterilization rack; A circulating water constant pressure system, which is arranged above the sterilizer and is connected with the water distribution system; A temperature uniform device, which is arranged on the circulating water constant pressure system; The water distribution temperature flow detection system is installed in the sterilization rack and is located below the water distribution system, and is used for detecting the flow and temperature of the water in the sterilization cavity; The water distribution temperature flow detection system comprises: A measurement water platform, which is installed on the sterilization rack; A measurement platform, which is slidingly connected to the measurement water platform; A plurality of water collection temperature collectors, which are arranged on the measurement platform and are located below the water distribution system; The water collection temperature collector comprises: A support, wherein a hollow installation cavity is arranged in the support; An open funnel, which is arranged in the installation cavity; A liquid collecting pipe, which is arranged in the installation cavity and is sealingly connected with the lower part of the open funnel at the top; A variable-diameter pipeline, which is arranged in the installation cavity and is sealingly connected with the lower part of the liquid collecting pipe at the top; A water flow guide pipe, which is sealingly connected with the lower part of the variable-diameter pipeline; An ultrasonic flow meter, which is connected with the water flow guide pipe; A temperature probe, one end of which is arranged in the liquid collecting pipe and the other end of which is arranged outside the support; A control box, which is in communication connection with the temperature probe and the ultrasonic flow meter; Wherein, the diameter of the bottom of the open funnel > the diameter of the bottom of the liquid collecting pipe > the diameter of the bottom of the variable-diameter pipeline; The measurement platform is slidingly connected to the measurement water platform through a control component, the control component comprises a servo motor, a synchronous belt, a moving balance guide rod, and a synchronous belt cluster drive wheel, one end of the synchronous belt is sleeved on the output end of the servo motor, the other end of the synchronous belt is sleeved on the synchronous belt cluster drive wheel installed on the measurement water platform, the moving balance guide rod is arranged on the measurement water platform, and the measurement platform is slidingly sleeved on the moving balance guide rod; the synchronous belt is fixedly connected with the measurement platform; The water distribution temperature flow detection system of the water bath sterilization equipment further comprises a heating heat exchange device and a refrigeration heat exchange device in communication with the temperature uniformizing device respectively; The water distribution system comprises: The cabinet constant pressure pipe is in communication with the water outlet end of the circulating water constant pressure system; The shunt pipes are equally spaced connected on the cabinet constant pressure pipe; The water distribution disc is provided on the top of the sterilization cavity, and each water distribution disc is provided with a water storage cavity, a plurality of first water leakage holes are arranged on the bottom of the water storage cavity, and each water distribution disc is provided with a shunt pipe; The shunt pipe is arranged in the shunt pipe. The shunt pipe is U-shaped, the middle part of the shunt pipe is connected to the cabinet constant pressure pipe, two shunt pipes are arranged on each water distribution disc, the two ends of the U-shaped shunt pipe are arranged in the shunt pipe, and a flow adjusting disc is arranged at the two ends of the shunt pipe. The circulating water constant pressure system comprises: The balance pipe is in communication with the water outlet of the temperature uniformizing device; The constant pressure tank is in communication with the outlet of the balance pipe; The water outlet of the constant pressure tank is connected with the cabinet constant pressure pipe, the cabinet constant pressure pipe is connected with the cabinet constant pressure pipe through the connecting pipe, and the connecting pipe is sealingly and fixedly arranged on the side wall of the sterilizer; the heating heat exchange device comprises a heating heat exchanger and a first water pump, the water inlet end of the first water pump is in communication with the bottom of the sterilizer, the water outlet end of the first water pump is in communication with the water inlet of the heating heat exchanger, and the water outlet of the heating heat exchanger is connected with the water inlet of the mixing pipe in the temperature uniformizing device; the sterilization rack comprises: a plurality of stacked sterilization boxes, the sterilization box is provided with a placing cavity, the bottom of the sterilization box has a hollow interlayer, a plurality of second water leakage holes are arranged in the top wall of the hollow interlayer, and a plurality of third water leakage holes are arranged in the bottom wall of the hollow interlayer.

2. The method according to claim 1, wherein the water temperature and flow rate of the water distribution device for the water bath sterilization of the large-volume infusion product are detected. The water temperature of the sterilizer needs to be set to a fixed temperature before detection, and the cycle is continued.

3. The water temperature and flow rate detection method for the water distribution of a water bath sterilization apparatus for infusion products according to claim 1, characterized in that, The water flow collector measures the circulating water flowing out of the holes of the water distribution disc; The water flow collector collects the circulating water flowing out of the holes of the water distribution disc, and transmits the data to the control box through the data line.

4. The water temperature and flow rate detection method for the water distribution of a water bath sterilization apparatus for infusion products according to claim 1, characterized in that, The ultrasonic flowmeter arranged at the end of the water flow guide pipe measures the flow of the circulating water; The circulating water flows through the variable diameter pipeline and then flows through the ultrasonic flowmeter through the water flow guide pipe, and the flow data of the circulating water in the sterilizer is transmitted to the control box through the data line of the ultrasonic flowmeter.

5. The method of claim 1, wherein the water temperature and flow rate of the water distribution device for the water bath sterilization of the infusion product are detected. After the control box collects the data transmitted by the temperature probe and the ultrasonic flowmeter, the data is collected at a frequency of one second when the data before and after each water flow collector is basically stable, and then the measurement platform is controlled to move to the position of the next row of medicine bottles until the data collection of the last row of medicine bottles is completed.

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