Oil-dispersed solid cosmetic composition containing adenosine

Abstract

The present invention relates to an oil-dispersed solid cosmetic composition containing adenosine. In the oil-dispersed solid cosmetic composition containing a dispersion liquid containing adenosine in a specified content ratio, adenosine is uniformly dispersed in the dosage form without precipitation problems, and a stable dosage form can be achieved, which has excellent effects on skin regeneration and wrinkle improvement.

Description

Technical Field

[0001] The present invention relates to an oil-dispersed solid cosmetic composition in which adenosine is uniformly dispersed and which has skin regeneration and wrinkle improvement effects. Background Art

[0002] The skin is roughly divided into three layers, namely the epidermis, dermis, and subcutaneous tissue from the outside to the inside, and has the function of protecting internal organs from temperature and humidity changes, ultraviolet rays, and other physical and chemical external environmental stimuli.

[0003] In particular, the epidermis plays an important role in preventing the evaporation of internal moisture in the human body. The epidermis is divided into the stratum corneum, stratum granulosum, stratum spinosum, and stratum basale from the outside to the inside. The cells of the stratum corneum play a role similar to bricks, and the intercellular lipids between corneocytes play a role similar to mortar, constituting the skin barrier. Moreover, a high concentration of Natural Moisturing Factor (NMF) exists in the corneocytes of healthy people, which helps the skin retain moisture. Substances such as amino acids are water-soluble, so they effectively combine with water and inhibit skin moisture drying.

[0004] It is known that the causes of skin aging wrinkles are the accumulation of lipid peroxides harmful to the skin, oxidation by unsaturated fatty acids in skin contractility and elastic bodies, an increase in in vivo lipid peroxides, weakening of the fibers maintaining skin elasticity, the occurrence of skin wrinkles (Skinwrinkle), or the occurrence of skin aging phenomena such as pigmentation, which are caused by a decrease in the color quality of skin-accumulated cells that weaken skin elasticity and contractility, nuclear atrophy, etc., resulting in a decline in the skin wrinkling and aging contraction and convergence effects.

[0005] The convergence effect is to shrink (contract) pores, make the skin have tension, and endow the skin with elasticity. The main causes of oxidative skin aging are poor skin blood circulation, nutritional deficiency, degeneration and atrophy of elastic fiber-binding fiber muscle fibers in the dermis, induction of water or reduction of skin fat, resulting in the generation of free radicals in harmful reactive oxygen species, insufficient collagen, and an increase in the activity of elastase, which is an elastic fiber decomposition factor. These various reasons will weaken the elasticity and pore contractility of the skin.

[0006] However, due to various reasons such as recent environmental changes or lifestyle changes, artificial temperature regulation of cold / heating, skin stress caused by various stresses and environmental pollution in social life, frequent face washing due to makeup habits, and natural skin aging due to increasing age, the reduction of moisture in the stratum corneum leads to skin dryness, rough surface, skin relaxation, loss of luster, and dull appearance. Therefore, there is a need to develop a cosmetic composition for skin regeneration and wrinkle improvement.

[0007] On the other hand, adenosine, as a nucleoside involved in extracellular signal transduction, is a substance present in all organisms. It is directly involved in cell growth and differentiation. When adenosine at a concentration of 0.04% or more is used as a raw material for a cosmetic composition, it is recognized as a functional cosmetic for wrinkle improvement. Adenosine promotes the synthesis of proteins and collagen in the dermis, increases cell proliferation and self-renewal ability, helps prevent skin aging, and makes the skin elastic. Moreover, adenosine is a substance present in cells, is a major component of cell energy metabolism, has a low molecular weight, and is considered a thermodynamically safe substance that does not accumulate in the body. Especially when it penetrates into the skin, it has excellent stability and persistence, and is also stable to ultraviolet rays, so it can be used day and night.

[0008] Existing oil-dispersed solid cosmetic compositions contain adenosine components that help improve wrinkles, but due to improper dispersion, there is a problem that the measured adenosine content varies in each content. Especially in the case of solid stick form, if the dispersion is uneven, it will solidify, and the adenosine component will concentrate in the lower part of the stick, and there is no adenosine in the upper part. Therefore, it is difficult to expect the desired wrinkle improvement effect when applied to the skin.

[0009] Therefore, there is an urgent need to develop an oil-dispersed solid cosmetic composition in which adenosine does not precipitate in the dosage form. Summary of the Invention

[0010] Technical Problem

[0011] For this reason, the present inventors have devoted themselves to preparing an oil-dispersed solid cosmetic composition by mixing dispersions containing adenosine in a specified content ratio, so that adenosine is uniformly dispersed in the dosage form without precipitation problems and has excellent effects on skin regeneration and wrinkle improvement.

[0012] Therefore, an object of the present invention is to provide an oil-dispersed solid cosmetic composition comprising an adenosine dispersion, wax, oil, and plant butter.

[0013] Solution to the Problem

[0014] Hereinafter, the present invention will be described in more detail.

[0015] One aspect of the present invention relates to an oil-dispersed solid cosmetic composition, comprising an adenosine dispersion, wax, oil, and vegetable butter.

[0016] In the present invention, the adenosine dispersion may comprise one or more selected from the group consisting of polyols, adenosine, and hydrogenated lecithin, but is not limited thereto.

[0017] In the present invention, based on the total weight of the cosmetic composition, the content of the adenosine dispersion may be 1.0 - 3.0 wt%, 1.5 - 2.5 wt%, 2.0 - 3.0 wt%, 2.0 - 2.5 wt%, for example, 2.0 wt%, but is not limited thereto.

[0018] In the present invention, the polyol may be one or more selected from the group consisting of butylene glycol and glycerin, but is not limited thereto.

[0019] In the present invention, based on the total weight of the cosmetic composition, the content of the polyol may be 1.84 - 1.88 wt%, 1.84 - 1.87 wt%, 1.84 - 1.86 wt%, 1.85 - 1.88 wt%, 1.85 - 1.87 wt%, 1.85 - 1.86 wt%, 1.86 - 1.88 wt%, 1.86 - 1.87 wt%, for example, 1.86 wt%, but is not limited thereto.

[0020] In the present invention, based on the total weight of the cosmetic composition, the content of adenosine may be 0.02 - 0.06 wt%, 0.02 - 0.05 wt%, 0.02 - 0.04 wt%, 0.03 - 0.06 wt%, 0.03 - 0.05 wt%, 0.04 - 0.06 wt%, 0.04 - 0.05 wt%, for example, 0.04 wt%, but is not limited thereto.

[0021] In the present invention, based on the total weight of the cosmetic composition, the content of hydrogenated lecithin may be 0.1 wt%, but is not limited thereto.

[0022] In the present invention, the weight ratio of polyol, adenosine, and hydrogenated lecithin may be 92:3:5 to 94:1:5, for example, 93:2:5, but is not limited thereto.

[0023] In the present invention, the wax may be one or more selected from the group consisting of candelilla wax, microcrystalline wax, rice bran wax, sunflower seed wax, ozokerite, synthetic wax, polyethylene, shellac, and beeswax, but is not limited thereto.

[0024] In the present invention, relative to the total weight of the cosmetic composition, the content of the wax may be 10.0 - 20.0% by weight, 10.0 - 18.0% by weight, 10.0 - 16.0% by weight, 12.0 - 20.0% by weight, 12.0 - 18.0% by weight, 12.0 - 16.0% by weight, 14.0 - 20.0% by weight, 14.0 - 18.0% by weight, 14.0 - 16.0% by weight, for example, 15.0% by weight, but is not limited thereto.

[0025] In the present invention, the oil may be one or more selected from the group consisting of sunflower oil, sweet almond oil, apple seed oil, octyldodecanol, and polyglyceryl-2 triisostearate, but is not limited thereto.

[0026] In the present invention, relative to the total weight of the cosmetic composition, the content of the oil may be 70.0 - 86.0% by weight, 70.0 - 84.0% by weight, 70.0 - 82.0% by weight, 70.0 - 80.0% by weight, 70.0 - 78.0% by weight, 72.0 - 86.0% by weight, 72.0 - 84.0% by weight, 72.0 - 82.0% by weight, 72.0 - 80.0% by weight, 72.0 - 78.0% by weight, 74.0 - 86.0% by weight, 74.0 - 84.0% by weight, 74.0 - 82.0% by weight, 74.0 - 80.0% by weight, 74.0 - 78.0% by weight, 76.0 - 86.0% by weight, 76.0 - 84.0% by weight, 76.0 - 82.0% by weight, 76.0 - 80.0% by weight, 76.0 - 78.0% by weight, for example, 77% by weight, but is not limited thereto.

[0027] In the present invention, the vegetable butter may be one or more selected from the group consisting of shea butter, cupuaçu butter, cocoa seed butter, and mango seed butter, but is not limited thereto.

[0028] In the present invention, relative to the total weight of the cosmetic composition, the content of the vegetable butter may be 3.0 - 7.0% by weight, 3.0 - 6.0% by weight, 3.0 - 5.0% by weight, 4.0 - 7.0% by weight, 4.0 - 6.0% by weight, 4.0 - 5.0% by weight, for example, 5.0% by weight, but is not limited thereto.

[0029] In the present invention, the oil-dispersed solid cosmetic composition may further contain an antioxidant, but is not limited thereto.

[0030] In the present invention, the antioxidant may be tocopherol and tocopheryl acetate, but is not limited thereto.

[0031] In the present invention, relative to the total weight of the cosmetic composition, the content of the antioxidant may be 0.05-0.2% by weight, 0.05-0.15% by weight, 0.05-0.1% by weight, 0.08-0.2% by weight, 0.08-0.15% by weight, 0.08-0.1% by weight, for example, 0.1% by weight, but is not limited thereto.

[0032] Effects of the Invention

[0033] The present invention relates to an oil-dispersed solid cosmetic composition containing adenosine. In the oil-dispersed solid cosmetic composition containing a dispersion liquid containing adenosine in a specified content ratio, adenosine is uniformly dispersed in the dosage form without precipitation problems, and a stable dosage form can be achieved, which has excellent effects on skin regeneration and wrinkle improvement. BRIEF DESCRIPTION OF THE DRAWINGS

[0034] Figure 1 A photograph showing the dosage form of Example 1 prepared according to a preparation example of the present invention. DETAILED DESCRIPTION OF THE INVENTION

[0035] Hereinafter, the present invention will be described in more detail through the following examples. However, these examples are only for illustrating the present invention, and the scope of the present invention is not limited to these examples.

[0036] Preparation Example: Preparation of Examples and Comparative Examples

[0037] The oil-dispersed solid cosmetic compositions of Example 1 and Comparative Example 1 were prepared according to the components and contents described in Table 1 below.

[0038] Table 1

[0039]

[0040] Specifically, after measuring each raw material according to the components and contents described in Table 1 into a beaker, it was heated to 80-85 °C to completely dissolve the raw materials. Then, for dispersion, a vacuum emulsifier (Agi-mixer) was stirred at 100-150 rpm at 80-85 °C. Then, Example 1 and Comparative Example 1 were prepared by removing bubbles.

[0041] Experimental Example 1: Potency Test

[0042] In a constant temperature bath at room temperature and 45 °C, for the content of adenosine in the dosage forms of the prepared Example and Comparative Example 1, it was measured immediately after preparation, and after storing for 1 week, 2 weeks, and 4 weeks. The comparison results of the contents are shown in Table 2 below. At this time, the upper layer, middle layer, and lower layer of the oil-dispersed solid cosmetic composition were analyzed once each, and the average value was taken and compared to analyze the content.

[0043] Table 2

[0044]

[0045] As can be confirmed from Table 2 above, when measuring the adenosine content in the rod-shaped product immediately after preparation, Example 1 and Comparative Example 1 showed similar adenosine contents. On the contrary, the adenosine content in the rod-shaped product after storage for 4 weeks in Example 1 hardly changed, but in Comparative Example 1, it was 0.029% at room temperature and 0.018% at 45°C after storage for 4 weeks, which was lower than the content when measured immediately after preparation. Such results mean that in Comparative Example 1, adenosine in the oil-dispersed solid cosmetic composition dosage form was not normally dispersed, and even though the content was the same, the potency decreased according to the part. This is because there is a difference in the content of hydrogenated lecithin in the adenosine dispersion. If the phospholipids, which are the main components of lecithin, are homogenized, fine lipid particles will be formed, and at this time, adenosine will be dispersed together. Without a sufficient amount of hydrogenated lecithin, adenosine cannot be normally dispersed and will precipitate in the lower part of the rod-shaped product.

[0046] From this, it can be confirmed that only by containing an appropriate amount of hydrogenated lecithin and polyol can adenosine be uniformly dispersed in the rod-shaped product.

Claims

1. An oil-dispersed solid cosmetic composition, comprising: An adenosine dispersion comprising butylene glycol, adenosine, and hydrogenated lecithin, wherein the weight ratio of butylene glycol, adenosine, and hydrogenated lecithin is from 92:3:5 to 94:1:5; Waxes, which include candelilla wax and microcrystalline wax; Oils, which include sunflower seed oil, sweet almond oil, apple seed oil, octyldodecanol, and polyglyceryl-2 triisostearate; Shea butter; and Tocopherol.

2. The oil-dispersed solid cosmetic composition according to claim 1, characterized in that, The content of the adenosine dispersion is 1.0 - 3.0% by weight based on the total weight of the cosmetic composition.

3. The oil-dispersed solid cosmetic composition according to claim 1, characterized in that, The content of the butylene glycol is 1.84 - 1.88% by weight based on the total weight of the cosmetic composition.

4. The oil-dispersed solid cosmetic composition according to claim 1, characterized in that, The content of the adenosine is 0.02 - 0.06% by weight based on the total weight of the cosmetic composition.

5. The oil-dispersed solid cosmetic composition according to claim 1, wherein The content of the hydrogenated lecithin is 0.1% by weight based on the total weight of the cosmetic composition.

6. The oil-dispersed solid cosmetic composition according to claim 1, characterized in that, The content of the waxes is 10.0 - 20.0% by weight based on the total weight of the cosmetic composition.

7. The oil-dispersed solid cosmetic composition according to claim 1, wherein The content of the oils is 70.0 - 86.0% by weight based on the total weight of the cosmetic composition.

8. The oil-dispersed solid cosmetic composition according to claim 1, characterized in that, The content of the shea butter is 3.0 - 7.0% by weight based on the total weight of the cosmetic composition.

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