A quantitative evaluation method for cosmetics quality based on four properties of cosmetics

Abstract

The present invention discloses a method for quantitatively evaluating the quality of cosmetics based on the four properties of cosmetics, including selecting detection indicators and establishing a quantitative system; wherein the detection indicators include four dimensions: safety, efficacy, usability and stability. The method for establishing a quantitative system is: define the safety score as A, the efficacy score as B, the usability score as C, the stability score as D, and the total quality evaluation score calculation formula as 0.5A (0.3C + 0.7D) + B. The present invention uses the evaluation results to provide producers and regulators with more comprehensive quality management and supervision data, provide technical data for product upgrades of producers and operators, and provide guiding data for operators and consumers to choose better products.

Description

Technical Field

[0001] The present invention relates to the technical field of cosmetic product quality evaluation, and in particular to a method for quantitatively evaluating cosmetic quality based on four properties of cosmetics. Background Art

[0002] With the development of the economy and the improvement of people's living standards, the cosmetics market is gradually expanding. It is expected that by 2025, China's cosmetics market will expand to 145 billion US dollars. In the past two years, the state has gradually tightened the quality control of cosmetics. From 2020 to 2022, my country has successively issued about 20 laws, regulations and technical documents such as the "Regulations on the Supervision and Administration of Cosmetics", "Guiding Principles for Efficacy Evaluation", and "Technical Specifications for Cosmetic Safety" (2022 Edition). Chinese consumers have also gradually changed from "advertising type" to "quality type", and consumers are paying more and more attention to the quality of products. Therefore, it is extremely important to establish a cosmetics quality evaluation system.

[0003] At present, the quality evaluation methods of various products are mostly aimed at evaluating the safety of products, and there is almost no evaluation system that conducts a comprehensive evaluation of the quality of cosmetics. Most evaluation methods are also qualitative evaluations, which can provide data support for quality management and market supervision for producers and regulators, but have little significance for guiding producers and consumers in product upgrades and consumer choices. Summary of the invention

[0004] The purpose of the present invention is to address the deficiencies of the prior art and to provide a method for quantitatively evaluating the quality of cosmetics based on the four properties of cosmetics, so as to use the evaluation results to provide producers and regulators with more comprehensive quality management and supervision data, provide technical data for product upgrades of production operators, and provide guiding data for operators and consumers to choose better quality products.

[0005] The present invention discloses a method for quantitatively evaluating the quality of cosmetics based on the four properties of cosmetics, comprising selecting detection indicators and establishing a quantitative system; wherein the detection indicators include four dimensions: safety, efficacy, usability and stability.

[0006] The method for quantitatively evaluating the quality of cosmetics based on the four properties of cosmetics described in the present invention, wherein the safety detection indicators include five microbial items, element screening, preservatives, hormones, antibiotics, flavors and fragrances, and human skin patch test;

[0007] Hair products need to be tested for anti-dandruff agents, whitening and sunscreen products need to be tested for sunscreens, hair dye products need to be tested for hair dyes, perfumes and nail polish products need to be tested for plasticizers and banned volatile organic solvents, makeup products need to be tested for colorants, and risk substances should be tested based on the characteristics of the formula. Whitening products need to be tested for hydroquinone, anti-hair loss products need to be tested for minoxidil, perm products need to be tested for thioglycolic acid, oral products need to be tested for triclosan, triclocarban, soluble fluoride, total fluoride, benzalkonium bromide and hard particles, and scrub products and toothpaste products need to be tested for plastic microbeads.

[0008] The method for quantitatively evaluating the quality of cosmetics based on the four properties of cosmetics described in the present invention, wherein the detection method is one of the following:

[0009] Methods specified in relevant national standards, industry standards, and technical specifications of my country, and methods specified in relevant foreign laws, regulations, or technical standards;

[0010] Methods for issuing technical guidelines from authoritative organizations, technical institutions and industry associations at home and abroad;

[0011] Rapid screening methods published in professional academic journals and periodicals;

[0012] If the rapid screening method detects suspicious values ​​or values ​​exceeding the standard, retesting will be carried out using the arbitration method in my country's mandatory national standards and technical specifications.

[0013] The method for quantitatively evaluating the quality of cosmetics based on the four properties of cosmetics described in the present invention, wherein the efficacy detection indicators include freckle removal and whitening, sun protection, anti-hair loss, acne removal, nourishment, repair, anti-wrinkle, firming, soothing, oil control, exfoliation, anti-hair breakage, anti-dandruff, moisturizing, hair care, suitable for sensitive skin, tear-free formula, mild and non-irritating, quantitative indicators (time, statistical data, etc.) and new efficacy claims.

[0014] The method for quantitatively evaluating the quality of cosmetics based on the four properties of cosmetics described in the present invention, wherein the evaluation method for efficacy is selected from one or a combination of human efficacy evaluation tests, consumer use tests and laboratory evaluation methods, and literature or research data are used as auxiliary supporting materials;

[0015] The evaluation methods for freckle removal and whitening, sun protection, hair loss prevention, acne removal, nourishment, and repair efficacy must include human efficacy evaluation tests, except for the freckle removal and whitening efficacy evaluation methods of products with physical covering mechanisms and the nourishment and repair efficacy evaluation methods of hair products;

[0016] The evaluation method for sensitive skin and tear-free formulations must include either a human efficacy evaluation test or a consumer use test;

[0017] The laboratory evaluation method adopts an integrated strategy based on weight of evidence to evaluate laboratory methods, and draws on the concept of "adverse outcome pathway AOP" in toxicological evaluation; similar to the concept of "AOP" in toxicology, cosmetics produce efficacy after being applied to the human body, and its pathway and mode of action are divided into "molecular initiation events", "key events and their interaction relationship events" and "result events";

[0018] The integrated strategy scheme is a "top-down" research strategy, and the preferred order of selecting the starting point of the experiment is: in vitro tissue experiment > 3D tissue model experiment > cell model experiment > in vivo animal experiment > other lower organism model experiments.

[0019] The method for quantitatively evaluating the quality of cosmetics based on the four properties of cosmetics described in the present invention, wherein the usability detection index includes product appearance evaluation, odor evaluation, and skin feel evaluation during and after use, and the detection method is performed by a professionally trained assessor for sensory evaluation;

[0020] Among them, the inspection indicators for product appearance evaluation include: the texture of the outer packaging material, the pleasantness of the outer packaging material pattern design, the beauty of the outer packaging material color, the feeling of unsealing the outer packaging material, the portability of the inner packaging material packaging, the feeling of unsealing the inner packaging material, the ease of taking out the contents, the controllability of the amount used, the airtightness of the inner packaging material, the pleasantness of the content color and the uniformity of the content paste;

[0021] The detection indexes of the odor evaluation include the odor of the packaging material and the fragrance of the contents;

[0022] The detection indexes of the skin feel evaluation during use include lubricity, extensibility and absorbency;

[0023] The detection indicators of the skin feel evaluation after use include skin feel, coverage feeling and holding time.

[0024] The method for quantitatively evaluating the quality of cosmetics based on the four properties of cosmetics of the present invention, wherein the detection indexes of usability include quality sensory, physical and chemical properties, temperature aging and light aging;

[0025] The sensory quality detection indicators include color, smell and appearance;

[0026] The detection indexes of the physical and chemical properties include pH value, cold and heat resistance test, relative density and centrifugal stability;

[0027] The temperature aging detection indexes include outer packaging form, odor, content appearance, content pH value, relative density and centrifugal stability; the temperature aging test is divided into three stages, namely short-term, medium-term and long-term, the short-term is 1 week to 4 weeks, the medium-term is 1 month to 3 months, and the long-term is 5 months to 7 months. The temperature and humidity conditions are: temperature: 40±1°C, humidity: 75±5%;

[0028] The detection indexes of light aging include color and pH value. The light aging test is divided into three stages, namely short-term, medium-term and long-term. The short-term is 6h to 10h; the medium-term is 14h to 18h; the long-term is 22h to 26h. The illumination condition is that the irradiation intensity in the 300-800nm ​​spectrum reaches 500W / m 2 .

[0029] The method for quantitatively evaluating the quality of cosmetics based on the four properties of cosmetics described in the present invention, wherein the method for establishing a quantitative system is: defining the safety score as A, the efficacy score as B, the usability score as C, the stability score as D, and the total quality evaluation score calculation formula as 0.5A(0.3C+0.7D)+B.

[0030] In the method for quantitatively evaluating the quality of cosmetics based on the four properties of cosmetics described in the present invention, when the score of any one of A, B, C, and D is 0, the evaluation is terminated and the product is finally evaluated as unqualified.

[0031] The method for quantitatively evaluating the quality of cosmetics based on the four properties of cosmetics described in the present invention comprises:

[0032] The A value is determined as follows: when the product is detected to contain ingredients prohibited by regulations, the A value is 0; when ingredients that do not conform to the label are detected, if the ingredient is an antioxidant, preservative, stabilizer, etc., and the content is lower than the maximum limit allowed by the relevant standards of my country, the A value is 0.6, otherwise the A value is 0; if the microbial limit test does not meet the national standards, the A value is 0; if a suspicious skin reaction occurs in the human skin patch test, the A value is 0.6, if a weak positive reaction or above occurs, the A value is 0; in other cases, the A value is 1; when there are multiple possible values ​​for the A value, the final value of the A value is the product of the multiple possible A values, that is, A=A1A2···A n ;

[0033] The B value is determined as follows: 30 points are assigned when there is reliable human experimental data; 20 points are assigned when there is reliable consumer use test data; when conducting laboratory method evaluation based on an integrated strategy, each module in the integrated strategy is assigned a value according to the weight of evidence, 5 points are assigned to molecular initiation events, 15 points are assigned to key events at the cellular level, 20 points are assigned to key events based on 3D skin models and in vitro tissues, and 5 points are assigned to methods based on animal test models with clear mechanisms. Multiple test indicators in each module can be cumulatively assigned, and the total score shall not exceed 30 points; if there are references or research data as evidence, 5 points are assigned to each document or data, with a maximum of 10 points; when there are multiple possible values ​​for the B value, the final value of the B value is the sum of multiple possible B values, that is, B=B1+B2+···+Bn ; When the same product has multiple efficacy claims, each efficacy claim is scored independently, and then all scores are added together and divided by the number of efficacy claims, that is, Among them, B n is the score of a single efficacy claim, and n is the number of efficacy claims;

[0034] The C value is calculated as follows: the score of each item of usability is 0 to 4 points, and the final C value is obtained by adding up all the scores of the individual items, that is, C = C1 + C2 + ··· + C n ;

[0035] The D value is determined as follows: D=XY(75aZ1+25bZ2); wherein X and Y are the quality sensory and physicochemical property scores in the stability assessment. When all the quality sensory or physicochemical property test items meet the corresponding industry standards, X or Y is 1, otherwise it is 0; a and b are constant terms. When the evaluated sample undergoes short-term thermal / light stability evaluation, a / b is 0.6, after medium-term thermal / light stability evaluation, a / b is 0.8, and after long-term thermal / light stability evaluation, a / b is 1; Z1 and Z2 are the thermal stability and light stability evaluation result scores, respectively. When the thermal / light stability test is completed, if the corresponding index is still within the standard range and the deviation of all indexes from the indexes before the experiment is within ±5%, Z1 or Z2 is 1, if the deviation is within ±10%, Z1 or Z2 is 0.8, if the deviation exceeds ±10%, Z1 or Z2 is 0.6, and if any one of the indexes is unqualified, Z1 or Z2 is 0.

[0036] The method for quantitatively evaluating the quality of cosmetics based on the four properties of cosmetics of the present invention is different from the prior art in that:

[0037] The method of the present invention for quantitatively evaluating the quality of cosmetics based on the four properties of cosmetics adopts a multi-dimensional comprehensive method to explore the evaluation scheme for quantitative cosmetics quality, including indicators of four dimensions: safety, efficacy, usability, and stability of cosmetics, involving subjective evaluation, analytical chemistry, biochemistry, cell biology, molecular biology, and clinical evaluation, and quantifying various types of complex evaluation results through mathematical models. The evaluation method provided by the present invention can provide a multi-dimensional, multi-indicator comprehensive evaluation for the quality of cosmetics, and its evaluation results can provide data support for the quality control of cosmetics producers and the market supervision of supervisors, and also provide guidance for consumers to choose better products.

[0038] The method for quantitatively evaluating the quality of cosmetics based on the four properties of cosmetics of the present invention is further described below in conjunction with the accompanying drawings. BRIEF DESCRIPTION OF THE DRAWINGS

[0039] Figure 1The figure is a flow chart of the method for quantitatively evaluating the quality of cosmetics based on the four properties of cosmetics according to the present invention. DETAILED DESCRIPTION

[0040] Example 1

[0041] A method for quantitatively evaluating the quality of cosmetics based on the four properties of cosmetics, comprising the following steps:

[0042] a) Document review

[0043] The cosmetic products to be evaluated and their registration / filing information are reviewed. If the filing information does not match the commercially available packaging, the evaluation is withdrawn. Then, evaluation indicators are set based on product type and label claims, including four dimensions: safety, efficacy, usability, and stability.

[0044] b) Safety index detection

[0045] Appropriate safety indicators can be selected based on product characteristics and formula. The detection method can be any one of the methods specified in relevant national standards, industry standards, and technical specifications of my country, methods specified in relevant foreign laws and regulations or technical standards, methods published in technical guidelines of authoritative organizations, technical institutions and industry associations at home and abroad, and rapid screening methods published in professional academic journals and periodicals.

[0046] c) Efficacy index testing

[0047] According to the product claims, select appropriate testing indicators for evaluation. The evaluation methods can include one or a combination of human efficacy evaluation tests, consumer use tests and laboratory methods. Literature or research data can be used as auxiliary supporting materials.

[0048] d) Usability index testing

[0049] Obtained through subjective evaluation by professionals.

[0050] e) Stability index detection

[0051] Evaluate the changes in the quality of samples under specific thermal and light environments.

[0052] The following are specific embodiments:

[0053] A brand of hyaluronic acid rejuvenating essence single-use serum

[0054] After comparing the information on the National Medical Products Administration's cosmetics registration and filing platform, the essence's filing information is complete, and the product packaging and formula are consistent with the packaging uploaded to the system, and it proceeds to the next step of evaluation.

[0055] The safety testing indicators determined according to the product type and formula table are five microbial items, element screening, risk substances (dioxane), preservatives, hormones, antibiotics, flavors and fragrances, and human skin patch test. Element screening uses X-ray fluorescence spectroscopy for rapid screening and testing, and other tests are conducted using the "Technical Specifications for Safety of Cosmetics" or the standard methods in the corresponding national standards. A total of 23 preservatives, 97 hormones, 36 antibiotics, and 19 flavors and fragrances were tested. The human patch test included 30 people.

[0056] After testing, all safety items met the limit requirements, no preservatives, hormones, or antibiotics were detected, and no one showed any adverse reactions in the human patch test. The comprehensive A-value score was 1.

[0057] The efficacy of the sample in this example is claimed to be anti-wrinkle and moisturizing, wherein the anti-wrinkle efficacy evaluation test method uses in vitro promotion of cell type I collagen expression (key event), in vitro anti-glycosylation reaction test (starting time), DPPH (starting time) and PTIO (starting time) tests; the moisturizing efficacy evaluation uses in vitro promotion of cell filaggrin production test and in vitro promotion of cell aquaporin-3 production test, so B (anti-wrinkle) score is 15+5+5+5=30 points; B (moisturizing) score is 15+15=30 points. The comprehensive score of item B is (30+30) / 2=30 points.

[0058] The usability evaluation results are shown in the table below, and the C value is 98 points.

[0059]

[0060]

[0061] The stability evaluation results are shown in the table below. The D value is divided into 1×1(75×0.8×1+25×0.8×1)=80.

[0062]

[0063] Based on the above evaluation results, the quality evaluation score of a certain brand of hyaluronic acid rejuvenating essence single-use essence in this embodiment is "72.7".

[0064] Example 2

[0065] A certain brand of enzyme silk mask

[0066] After comparing the information on the National Medical Products Administration's cosmetics registration and filing platform, the mask's filing information is complete, and the product packaging and formula list are consistent with the packaging uploaded to the system, and it proceeds to the next step of evaluation.

[0067] The safety testing indicators determined according to the product type and formula table are fluorescent agents, five microorganisms, element screening, risk substances (dioxane), preservatives, hormones, antibiotics, flavors and fragrances, and human skin patch tests. Element screening uses X-ray fluorescence spectroscopy for rapid screening and testing, and other tests are conducted using the "Technical Specifications for Safety of Cosmetics" or the standard methods in the corresponding national standards. A total of 23 preservatives, 97 hormones, 36 antibiotics, and 19 flavors and fragrances were tested. The human patch test included 30 people.

[0068] After testing, all safety items met the limit requirements, no fluorescent agents, hormones, and antibiotics were detected, and no one had any adverse reactions in the human patch test. The types of preservatives were consistent with the formula list, and the comprehensive A value score was 1.

[0069] The efficacy of the sample in this example is claimed to be moisturizing, and the efficacy evaluation method adopted is only literature research, and there is only one literature, so the comprehensive score of B is =5 points.

[0070] In the usability evaluation, the texture of the outer packaging was scored 2 points, the pleasantness of the outer packaging pattern design was 3 points, the unsealing feeling of the inner packaging was 2 points, the fragrance of the contents was 3 points, the tightness-softness after use was 3 points, and the remaining items were 4 points. The comprehensive C value score was 93 points.

[0071] Stability evaluation: The basic properties of the samples in this example meet the standards, and 8h photostability and 2-week thermal stability evaluations were performed. After the test, all test value deviations were <5%. The D value is divided into 1×1(75×0.6×1+25×0.6×1)=60.

[0072] Based on the above evaluation results, the quality evaluation score of a certain brand of enzyme silk mask in this embodiment is "39.95".

[0073] Example 3

[0074] A brand of gentlemen's perfume

[0075] After comparing the information on the National Medical Products Administration's cosmetics registration and filing platform, the perfume's filing information is complete, and the product packaging and formula are consistent with the packaging uploaded to the system, so it proceeds to the next step of evaluation.

[0076] The safety testing indicators determined according to the product type and formula table are plasticizers, volatile organic solvents, five microorganisms, element screening, risk substances (methanol), preservatives, hormones, antibiotics, flavors and fragrances, and human skin patch tests. Element screening uses X-ray fluorescence spectroscopy for rapid screening and testing, flavors and fragrances use gas chromatography literature methods, and plasticizers use literature methods. Other tests are all tested using the "Technical Specifications for Safety of Cosmetics" or the standard methods in the corresponding national standards. A total of 23 preservatives, 97 hormones, 36 antibiotics, 24 flavors and fragrances, and 37 volatile organic solvents were tested. The human patch test included 30 people.

[0077] After testing, all safety items met the limit requirements, no plasticizers, banned volatile organic solvents, hormones, antibiotics, and preservatives were detected, and no one had any adverse reactions in the human patch test. The types of flavors and fragrances were consistent with the formula list, and the comprehensive A value score was 1.

[0078] The samples in this embodiment belong to the category that does not require efficacy evaluation as stipulated in the "Evaluation Standards for Cosmetic Efficacy Claims", and the samples in this embodiment have not been evaluated for efficacy, and the B value is 0.

[0079] The usability evaluation is full marks, that is, the comprehensive score of C value is 100 points.

[0080] Stability evaluation: The basic properties of the samples in this example meet the standards, and 8h photostability and 2-week thermal stability evaluations were performed. After the test, all test value deviations were <5%. The D value is divided into 1×1(75×0.6×1+25×0.6×1)=60.

[0081] Based on the above evaluation results, the quality evaluation score of a certain brand of enzyme silk mask in this embodiment is "36".

[0082] Example 4

[0083] A brand of single-color eyeshadow

[0084] After comparing the information on the National Medical Products Administration's cosmetics registration and filing platform, the eye shadow registration information is complete, and the product packaging and formula list are consistent with the packaging uploaded to the system, and it proceeds to the next step of evaluation.

[0085] The safety testing indicators determined according to the product type and formula table are colorants, five microorganisms, element screening, risk substances (phenol, dioxane, asbestos, acrylamide), preservatives, hormones, antibiotics, flavors and fragrances, and human skin patch tests. Element screening uses X-ray fluorescence spectroscopy for rapid screening and testing, and flavors and fragrances use gas chromatography literature methods. Other tests are all tested using the "Cosmetic Safety Technical Specifications" or the standard methods in the corresponding national standards. A total of 23 preservatives, 97 hormones, 36 antibiotics, and 24 flavors and fragrances were tested. A total of 30 people were included in the human patch test.

[0086] After testing, the acrylamide content in the sample of this example is 0.54 mg / kg. According to the relevant provisions of the "Technical Specifications for Safety of Cosmetics", acrylamide is a prohibited ingredient, so the evaluation of this product is terminated and rated as "unqualified".

[0087] Example 5

[0088] Mousse fragrance shower gel of a certain brand

[0089] After comparing the information on the National Medical Products Administration's cosmetics registration and filing platform, the shower gel's filing information is complete, and the product packaging and formula are consistent with the packaging uploaded to the system, so it proceeds to the next step of evaluation.

[0090] The safety testing indicators determined according to the product type and formula table are five microbial items, element screening, risk substances (dioxane), preservatives, hormones, antibiotics, flavors and fragrances, and human skin patch test. Element screening uses X-ray fluorescence spectroscopy for rapid screening and testing, and flavors and fragrances use gas chromatography literature methods. Other tests are all tested using the "Cosmetic Safety Technical Specifications" or the standard methods in the corresponding national standards. A total of 23 preservatives, 97 hormones, 36 antibiotics, and 24 flavors and fragrances were tested. The human patch test included 30 people.

[0091] After testing, all safety items met the limit requirements, no hormones and antibiotics were detected, the preservatives were consistent with the label and within the standard limit, there was 1 suspicious reaction in the human patch test, and no other people had any adverse reactions, the flavors and fragrances were within the safe range, and the comprehensive A value score was 0.6.

[0092] The efficacy claims of the samples in this example are cleaning and moisturizing. Cleansing was not evaluated for efficacy. According to the "Evaluation Standards for Cosmetic Efficacy Claims", cleaning claims are not required for evaluation. 清洁 Take 0 and proceed to the next step of evaluation; the method used for moisturizing effect evaluation is only literature research, and there is only one literature, so the comprehensive score of B is = 5 points.

[0093] In the usability evaluation, the texture of the outer packaging was scored 2 points, the pleasantness of the outer packaging pattern design was 2 points, the fragrance of the contents was 3 points, the tightness-softness after use was 3 points, and the remaining items were 4 points. The comprehensive C value score was 94 points.

[0094] Stability evaluation: The basic properties of the samples in this embodiment meet the standards, and 8h light stability and 2 weeks of thermal stability evaluation were performed. After the test, the deviations of all test values ​​were <5%. The D value is 1×1(75×0.6×1+25×0.6×1)=60. Based on the above evaluation results, the quality evaluation score of a certain brand of mousse fragrance shower gel in this embodiment is "26.06".

[0095] Example 6

[0096] A brand of retinol night cream

[0097] After comparing the information on the National Medical Products Administration's cosmetics registration and filing platform, the night cream's filing information is complete, and the product packaging and formula are consistent with the packaging uploaded to the system, and it proceeds to the next step of evaluation.

[0098] The safety testing indicators determined according to the product type and formula table are five microbial items, element screening, risk substances (dioxane), preservatives, hormones, antibiotics, flavors and fragrances, and human skin patch test. Element screening uses X-ray fluorescence spectroscopy for rapid screening and testing, and flavors and fragrances use gas chromatography literature methods. Other tests are all tested using the "Cosmetic Safety Technical Specifications" or the standard methods in the corresponding national standards. A total of 23 preservatives, 97 hormones, 36 antibiotics, and 24 flavors and fragrances were tested. The human patch test included 30 people.

[0099] After testing, all safety items met the limit requirements, no hormones, antibiotics, flavors and fragrances were detected, the preservatives were consistent with the label and within the standard limit, and no one had any adverse reactions in the human patch test. The A value comprehensive score is 1.

[0100] The efficacy of the sample in this example is claimed to be moisturizing, anti-wrinkle, firming and soothing. The method used for moisturizing efficacy evaluation is only literature research, and there are two literatures, so B 保湿 The comprehensive score is 10 points; the anti-wrinkle efficacy evaluation method adopts the consumer use test method and the literature research method. Among them, the literature research only has one data, so B 抗皱 The comprehensive score is 20+5=25 points; the evaluation of firming effect and soothing effect are only based on the consumer use test method, so B 紧致 The overall score is 25 points, B 舒缓 The total score is 25 points. The final total score of B is (10+25+20+20) / 4=18.75 points

[0101] In the usability evaluation, the pleasantness of the aroma of the contents was 3 points, the other items were 4 points, and the comprehensive C value score was 99 points.

[0102] The stability evaluation results are shown in the table below. The D value is divided into 1×1(75×0.8×1+25×0.8×0.8)=76.

[0103]

[0104]

[0105] Based on the above evaluation results, the quality evaluation score of the A alcohol night cream in this embodiment is "60.2".

[0106] The embodiments described above are merely descriptions of preferred implementation modes of the present invention and are not intended to limit the scope of the present invention. Without departing from the design spirit of the present invention, various modifications and improvements made to the technical solutions of the present invention by ordinary technicians in this field should all fall within the protection scope determined by the claims of the present invention.

Claims

1. A method for quantitatively evaluating the quality of cosmetics based on four properties of cosmetics, characterized by: Including selecting detection indicators and establishing a quantitative system; wherein the detection indicators include four dimensions: safety, efficacy, usability and stability; The method for establishing the quantitative system is: define the safety score as A, the efficacy score as B, the usability score as C, the stability score as D, and the total quality evaluation score calculation formula as 0.5A(0.3C+0.7D)+B; When any of A, B, C, and D scores 0, the evaluation is terminated and the product is finally evaluated as unqualified; however, according to the "Evaluation Standards for Cosmetic Efficacy Claims", there is no mandatory requirement for efficacy evaluation of products, and when the B value is 0, the subsequent evaluation will continue; The A value is determined as follows: when the product is detected to contain ingredients prohibited by regulations, the A value is 0; when an ingredient that does not conform to the label is detected, if the ingredient is an antioxidant, preservative, or stabilizer, and the content is lower than the maximum limit allowed by the relevant standards of my country, the A value is 0.6, otherwise the A value is 0; if the microbial limit test does not meet the national standards, the A value is 0; if a suspicious skin reaction occurs in the human skin patch test, the A value is 0.6, and if a weak positive reaction or above occurs, the A value is 0; in other cases, the A value is 1; when there are multiple possible values ​​for the A value, the final value of the A value is the product of the multiple possible A values, that is, A=A1A2···A n ; The B value is determined as follows: 30 points are assigned when there is reliable human experimental data; 20 points are assigned when there is reliable consumer use test data; when conducting laboratory method evaluation based on an integrated strategy, each module in the integrated strategy is assigned a value according to the weight of evidence, 5 points are assigned to molecular initiation events, 15 points are assigned to key events at the cellular level, 20 points are assigned to key events based on 3D skin models and in vitro tissues, and 5 points are assigned to methods based on animal experimental models with clear mechanisms. Multiple test indicators in each module can be cumulatively assigned, and the total score shall not exceed 30 points; if there are references or research data as supporting materials, 5 points are assigned to each document or data, with a maximum of 10 points; when there are multiple possible values ​​for the B value, the final value of the B value is the sum of multiple possible B values, that is, B=B1+B2+···+B n ; When the same product has multiple efficacy claims, each efficacy claim is scored independently, and then all scores are added together and divided by the number of efficacy claims, that is, Among them, B n is the score of a single efficacy claim, and n is the number of efficacy claims; The C value is calculated as follows: the score of each item of usability is 0 to 4 points, and the final C value is obtained by adding up all the scores of the individual items, that is, C = C1 + C2 + ··· + C n ; The usability testing indicators include product appearance evaluation, odor evaluation, and skin feel evaluation during and after use. The testing method is performed by professionally trained assessors to conduct sensory evaluation; Among them, the inspection indicators for product appearance evaluation include: the texture of the outer packaging material, the pleasantness of the outer packaging material pattern design, the beauty of the outer packaging material color, the feeling of unsealing the outer packaging material, the portability of the inner packaging material packaging, the feeling of unsealing the inner packaging material, the ease of taking out the contents, the controllability of the amount used, the airtightness of the inner packaging material, the pleasantness of the content color and the uniformity of the content paste; The detection indexes of the odor evaluation include the odor of the packaging material and the fragrance of the contents; The detection indexes of the skin feel evaluation during use include lubricity, extensibility and absorbency; The detection indicators of the skin feel evaluation after use include skin feel, coverage feeling and holding time; The D value is determined as follows: D=XY(75aZ1+25bZ2); wherein X and Y are the quality sensory and physicochemical property scores in the stability assessment. When all the quality sensory or physicochemical property test items meet the corresponding industry standards, X or Y is 1, otherwise it is 0; a and b are constant terms. When the evaluated sample undergoes short-term thermal / light stability evaluation, a / b is 0.6, after medium-term thermal / light stability evaluation, a / b is 0.8, and after long-term thermal / light stability evaluation, a / b is 1; Z1 and Z2 are the thermal stability and light stability evaluation result scores, respectively. When the thermal / light stability test is completed, if the corresponding index is still within the standard range and the deviation of all indexes from the indexes before the experiment is within ±5%, Z1 or Z2 is 1, if the deviation is within ±10%, Z1 or Z2 is 0.8, if the deviation exceeds ±10%, Z1 or Z2 is 0.6, and if any one of the indexes is unqualified, Z1 or Z2 is 0.

2. The method for quantitatively evaluating the quality of cosmetics based on the four properties of cosmetics according to claim 1, characterized in that: The safety testing indicators include five microbial items, element screening, preservatives, hormones, antibiotics, flavors and fragrances, and human skin patch test; Hair products need to be tested for anti-dandruff agents, whitening and sunscreen products need to be tested for sunscreens, hair dye products need to be tested for hair dyes, perfumes and nail polish products need to be tested for plasticizers and banned volatile organic solvents, makeup products need to be tested for colorants, and risk substances should be tested based on the characteristics of the formula. Whitening products need to be tested for hydroquinone, anti-hair loss products need to be tested for minoxidil, perm products need to be tested for thioglycolic acid, oral products need to be tested for triclosan, triclocarban, soluble fluoride, total fluoride, benzalkonium bromide and hard particles, scrub products and toothpaste products need to be tested for plastic microbeads, and film products need to be tested for fluorescent agents.

3. The method for quantitatively evaluating the quality of cosmetics based on the four properties of cosmetics according to claim 1, characterized in that: The efficacy testing indicators include freckle removal and whitening, sun protection, anti-hair loss, acne removal, nourishing, repairing, anti-wrinkle, firming, soothing, oil control, exfoliation, anti-hair breakage, anti-dandruff, moisturizing, hair care, suitable for sensitive skin, tear-free formula, and mild and non-irritating.

4. The method for quantitatively evaluating the quality of cosmetics based on the four properties of cosmetics according to claim 3, characterized in that: The efficacy evaluation method is selected from one or a combination of human efficacy evaluation test, consumer use test and laboratory evaluation method, and literature or research data are used as auxiliary supporting materials; The evaluation methods for freckle removal and whitening, sun protection, hair loss prevention, acne removal, nourishment, and repair efficacy must include human efficacy evaluation tests, except for the freckle removal and whitening efficacy evaluation methods of products with physical covering mechanisms and the nourishment and repair efficacy evaluation methods of hair products; The evaluation method for sensitive skin and tear-free formulations must include either a human efficacy evaluation test or a consumer use test; The laboratory evaluation method adopts an integrated strategy based on weight of evidence to evaluate laboratory methods, and draws on the concept of "adverse outcome pathway AOP" in toxicological evaluation; cosmetics produce efficacy after being applied to the human body, and its action pathway and mode of action are divided into "molecular initiation events", "key events and their interaction relationship events" and "result events"; The integrated strategy is a "top-down" research strategy, and the order of experimental starting points is: in vitro tissue experiment > 3D tissue model experiment > cell model experiment > in vivo animal experiment > other lower organism model experiments.

5. The method for quantitatively evaluating the quality of cosmetics based on the four properties of cosmetics according to claim 4, characterized in that: The stability detection indicators include quality sensory, physical and chemical properties, temperature aging and light aging; The sensory quality detection indicators include color, smell and appearance; The detection indexes of the physical and chemical properties include pH value, cold and heat resistance test, relative density and centrifugal stability; The temperature aging detection indexes include outer packaging form, odor, content appearance, content pH value, relative density and centrifugal stability; the temperature aging test is divided into three stages, namely short-term, medium-term and long-term, the short-term is 1 week to 4 weeks, the medium-term is 1 month to 3 months, and the long-term is 5 months to 7 months. The temperature and humidity conditions are: temperature: 40±1°C, humidity: 75±5%; The photoaging detection indexes include color and pH value. The photoaging test is divided into three stages: It is short-term, medium-term and long-term. The short-term is 6h~10h; the medium-term is 14h~18h; the long-term is 22h~26h. The illumination condition is that the irradiance in the 300-800nm ​​spectrum reaches 500W / m 2 .

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