A composition and its use in the manufacture of a product having improved cardiac function

Abstract

The application discloses a kind of composition and its application in preparation with improved cardiac function product.The composition described herein, comprising the following components: (1) beta-nicotinamide mononucleotide or 1,6-fructose diphosphate tri-sodium salt, and (2) coenzyme Q 10 And vitamin complex.The composition described herein, beta-nicotinamide mononucleotide or 1,6-fructose diphosphate tri-sodium salt is combined with coenzyme Q 10 And vitamin complex, the composition obtained after combination has good prevention or treatment heart failure effect and the effect of improving cardiac function.Therefore, the composition described herein is used as active ingredient for preparing dietary supplement, health product or drug with prevention or treatment heart failure effect or with improving cardiac function, has important application value.

Description

Technical Field

[0001] This invention relates to the field of active composition technology, and more specifically to a composition and its application in the preparation of products that improve heart function. Background Technology

[0002] As we age, heart aging or disease manifests as mitochondrial dysfunction, decreased myocardial cell death and regeneration capacity, myocardial aging and inflammation, and is easily triggered by unhealthy lifestyle habits such as staying up late, smoking, and excessive drinking, leading to heart diseases such as heart failure, coronary heart disease, and myocardial infarction.

[0003] The most significant impact of aging is the increased proportion of senescent heart cells and the continuous decline in NAD+ levels in the heart. Multiple factors, including telomere shortening, DNA damage, chronic inflammation, and metabolic disorders, trigger cellular stress responses that damage heart cells, leading to impaired cardiac contraction and conduction functions. Heart disease is a major cause of morbidity and mortality in the elderly, and its incidence gradually increases with age.

[0004] β-Nicotinamide mononucleotide has wide applications in anti-aging and can effectively protect against cardiac aging. Fructose-1,6-bisphosphate has long been used as a pharmaceutical ingredient to assist in the treatment of heart diseases such as myocardial ischemia, and it is also included in the new food ingredient catalogue, meaning it can be used as a food additive.

[0005] The binding of β-nicotinamide mononucleotide (NMN) to fructose-1,6-bisphosphate not only rapidly and abundantly generates adenosine triphosphate (ATP), but also produces a large amount of NAD+ when NMN is bound to cardiac energy (ATP). This ensures the continuous expression of antioxidant enzymes and catalases in mitochondria, protecting mitochondria from age-related metabolic disorders, and comprehensively promotes and enhances the metabolic function of body cells.

[0006] Mitochondria are not only the primary source of adenosine triphosphate (ATP), the heart's energy source, but also key regulators of cardiomyocyte survival. Because the heart's own ATP reserves are very limited, a robust and continuous supply of ATP from mitochondria is essential to maintain heart function; otherwise, conditions such as heart failure may result.

[0007] Coenzyme Q 10 Widely used in the adjunctive treatment of cardiovascular diseases, these ingredients are also added to some nutritional supplements and dietary supplements. All of these ingredients have the effect of improving heart health and can be used as medications to assist in cardiac treatment; however, currently, almost all products on the market are single-ingredient products, and the combined effects they can provide are very limited. Therefore, more scientific and effective formulations are needed to allow for complementary advantages and better provide heart protection. Summary of the Invention

[0008] In order to solve at least one of the technical problems existing in the prior art, the present invention first provides a composition.

[0009] The composition provided by this invention comprises the following components:

[0010] (1) β-nicotinamide mononucleotide or trisodium fructose 1,6-bisphosphate, and

[0011] (2) Coenzyme Q 10 And multivitamins.

[0012] This invention discovered in its research that combining β-nicotinamide mononucleotide or trisodium 1,6-bisphosphate fructose with coenzyme Q... 10 The combination obtained by combining it with multivitamins has a good effect in preventing or treating heart failure and improving cardiac function.

[0013] The principle is as follows:

[0014] Nicotinamide mononucleotide (NMN) is a type of NAD+. + Nicotinamide is an intermediate involved in intracellular biosynthetic reactions. In vivo, nicotinamide can be directly synthesized into NMN via nicotinamide phosphoribosyltransferase (NAMPT). The expression activity of NAMPT limits NAD+ expression. + The level of synthesis will affect other NADs. + The activity of NAD-dependent enzymes + It is a coenzyme involved in a variety of enzymatic reactions, and cardiomyocytes can utilize NAD+. + Under the influence of NAD+, it gains vitality and generates more ATP for use by cardiomyocytes, meeting the heart's energy needs. + NAD levels decrease with age, and NMN can help replenish the body's NAD levels. + The deficiency leads to a decline in cardiac function, which in turn enhances the activity of various physiological responses within the heart and improves myocardial function.

[0015] Fructose-1,6-bisphosphate (FDB) acts on the cell membrane, regulating the activity of several enzymes in glucose metabolism, especially activating fructose-6-phosphate kinase, producing a large amount of ATP. This is beneficial for cardiomyocyte energy metabolism and glucose utilization, promoting cell repair and improving function. Clinically, FDB is used as a molecular-level drug to regulate the activity of several enzymes in glucose metabolism and restore and improve cell metabolism, thus restoring myocardial strength.

[0016] Coenzyme Q is a naturally occurring lipid compound found in cells and is essential for the human body. 10Widely distributed in cell membranes, especially mitochondrial membranes, it plays a crucial role in the energy utilization of cardiomyocytes, ensuring energy supply for cardiac cell activity and reducing oxidative stress and lipid peroxidation in cardiomyocytes. Coenzyme Q 10 It has the highest content in the heart and is most closely related to heart health. Supplementing with Coenzyme Q... 10 It can significantly improve the symptoms of heart failure and effectively reduce the mortality rate caused by heart failure.

[0017] Vitamin E has strong antioxidant properties, scavenging free radicals in the body and having a beneficial effect on chronic heart disease. Vitamin E can improve lipid metabolism, lower serum cholesterol levels, reduce the incidence of coronary heart disease and myocardial infarction, and also improve platelet function, preventing atherosclerosis. Vitamins B6 and B... 12 Its main functions include preventing cardiovascular disease, maintaining normal hematopoietic function, maintaining normal protein and fat metabolism, and protecting the heart. Vitamin B9 (folic acid) helps participate in the breakdown of active enzymes in the body, inhibits blood clot formation, ensures normal blood supply, and prevents arterial blockage and myocardial infarction. Vitamin B9 can lower the level of homocysteine ​​in the body, reducing atherosclerosis and thrombus formation.

[0018] This invention incorporates β-nicotinamide mononucleotide, fructose 1,6-bisphosphate, and coenzyme Q. 10 Vitamin B6, Vitamin B9, Vitamin B 12 Scientifically formulated, these ingredients work synergistically to fully mobilize myocardial cell energy metabolism, improve the utilization efficiency of several enzymes in glucose metabolism, combat cardiac aging, and exert antioxidant effects, further enhancing myocardial function. This helps prevent or treat heart failure and improve cardiac function.

[0019] Preferably, the composition comprises the following components:

[0020] (1) β-nicotinamide mononucleotide and trisodium fructose 1,6-bisphosphate, and

[0021] (2) Coenzyme Q 10 And multivitamins.

[0022] The inventors made a surprising discovery during their research: simultaneously combining β-nicotinamide mononucleotide and trisodium 1,6-bisphosphate with coenzyme Q... 10 When combined with multivitamins, its effects in preventing or treating heart failure or improving cardiac function are significantly stronger than those of β-nicotinamide mononucleotide or trisodium 1,6-bisphosphate with coenzyme Q alone. 10 A combination with multivitamins. Simultaneously, β-nicotinamide mononucleotide and trisodium 1,6-bisphosphate fructose are combined with coenzyme Q. 10When combined with multivitamins, it can synergistically enhance the composition's effects in preventing or treating heart failure or improving cardiac function.

[0023] Preferably, the composition contains β-nicotinamide mononucleotide, trisodium fructose 1,6-bisphosphate, and coenzyme Q. 10 The weight portions of the multivitamins are as follows:

[0024] 50-80 parts of β-nicotinamide mononucleotide, 10-20 parts of trisodium fructose 1,6-bisphosphate, and coenzyme Q. 10 10-20 servings, multivitamins 4-14 servings.

[0025] Preferably, the composition contains β-nicotinamide mononucleotide, trisodium fructose 1,6-bisphosphate, and coenzyme Q. 10 The weight portions of the multivitamins are as follows:

[0026] 50-80 parts of β-nicotinamide mononucleotide, 10-20 parts of trisodium fructose 1,6-bisphosphate, and coenzyme Q. 10 10-20 servings, multivitamins 4-14 servings.

[0027] Most preferably, the composition contains β-nicotinamide mononucleotide, trisodium fructose 1,6-bisphosphate, and coenzyme Q. 10 The weight portions of the multivitamins are as follows:

[0028] 60 parts of β-nicotinamide mononucleotide, 15 parts of trisodium fructose 1,6-bisphosphate, and coenzyme Q. 10 15 servings, 4 servings of multivitamins.

[0029] Preferably, the complex vitamins comprise vitamin E, vitamin B6, vitamin B9, and vitamin B1. 12 One or more of them.

[0030] Preferably, the composition contains vitamin E, vitamin B6, vitamin B9, and vitamin B1. 12 The weight parts are as follows:

[0031] Vitamin E 1-5 parts, Vitamin B6 0.5-2 parts, Vitamin B9 2-5 parts, Vitamin B 12 0.5-2 portions.

[0032] Most preferably, the composition contains vitamin E, vitamin B6, vitamin B9, and vitamin B1. 12 The weight parts are as follows:

[0033] Vitamin E 1 part, Vitamin B6 0.5 part, Vitamin B9 2 parts, Vitamin B 12 0.5 copies.

[0034] Preferably, the composition further comprises a traditional Chinese medicine extract; the traditional Chinese medicine extract is obtained by extracting Codonopsis pilosula and cinnamon.

[0035] In further research, the inventors surprisingly discovered that adding an extract obtained from Codonopsis pilosula and cinnamon using the method described in this invention to the composition can further enhance the composition's effect in preventing or treating heart failure or improving cardiac function.

[0036] Preferably, the herbal extract in the composition is 10 to 20 parts by weight.

[0037] Most preferably, the herbal extract is present in 15 parts by weight in the composition.

[0038] Preferably, the traditional Chinese medicine composition is prepared by the following method: Codonopsis pilosula and cinnamon are taken, and an organic solvent is added for ultrasonic extraction. After extraction, the extract is concentrated and dried to obtain the traditional Chinese medicine extract.

[0039] Preferably, the ultrasonic extraction refers to ultrasonic extraction for 20 to 40 minutes at 40 to 50°C, ultrasonic power of 300 to 500W, and ultrasonic frequency of 20 to 25KHz.

[0040] Most preferably, the ultrasonic extraction refers to ultrasonic extraction for 30 minutes at 45°C, with an ultrasonic power of 400W and an ultrasonic frequency of 25KHz.

[0041] Preferably, the weight ratio of Codonopsis pilosula to cinnamon is 1-3:1-3.

[0042] The most preferred ratio is 1:1 between the weight of Codonopsis pilosula and cinnamon.

[0043] Preferably, the added organic solvent is 8 to 12 times the total weight of Codonopsis pilosula and cinnamon.

[0044] Preferably, the organic solvent is composed of ethyl acetate and n-butanol.

[0045] Preferably, the volume ratio of ethyl acetate to n-butanol is 2-3:1-2;

[0046] Most preferably, the volume ratio of ethyl acetate to n-butanol is 3:2.

[0047] The inventors discovered in their research that extracts of traditional Chinese medicine (TCM) from Codonopsis pilosula and cinnamon obtained using different solvents exhibit varying degrees of enhancement in their effects on preventing or treating heart failure or improving cardiac function. It is not the case that extracts obtained using any solvent can significantly enhance or improve the effects of the composition on preventing or treating heart failure or improving cardiac function. Through numerous experiments, the inventors surprisingly found that extracts obtained from Codonopsis pilosula and cinnamon using ethyl acetate and n-butanol significantly enhance the effects of these extracts on preventing or treating heart failure or improving cardiac function compared to extracts obtained using other organic solvents. Adding these extracts to the composition significantly improves the composition's effects on preventing or treating heart failure or improving cardiac function, resulting in a composition with excellent preventative or therapeutic effects on heart failure or improvement of cardiac function.

[0048] The present invention also provides the use of the above composition in the preparation of products having the effect of preventing or treating heart failure.

[0049] The present invention also provides the use of the above composition in the preparation of a product having the effect of improving cardiac function.

[0050] Preferably, the product is a dietary supplement, health product, or medicine.

[0051] Beneficial effects: This invention provides a novel composition; the composition combines β-nicotinamide mononucleotide or trisodium 1,6-bisphosphate fructose with coenzyme Q. 10 The combination obtained by combining it with multivitamins has a good effect in preventing or treating heart failure and improving cardiac function. In particular, the simultaneous combination of β-nicotinamide mononucleotide and trisodium 1,6-bisphosphate with coenzyme Q10 has shown good effects. 10 When combined with multivitamins, the composition can synergistically enhance its effects in preventing or treating heart failure or improving cardiac function. Therefore, using this composition as an active ingredient in the preparation of dietary supplements, health products, or pharmaceuticals with preventative or therapeutic effects on heart failure or improved cardiac function has significant application value. Detailed Implementation

[0052] The present invention will be further described in detail below with reference to specific embodiments, but the embodiments do not limit the present invention in any way. All equivalent substitutions made based on the disclosure of this patent are within the protection scope of the present invention.

[0053] Example 1 Preparation of the composition

[0054] Raw material composition by weight: 75 parts β-nicotinamide mononucleotide, coenzyme Q10 15 servings, Vitamin E 1 serving, Vitamin B6 0.5 servings, Vitamin B9 2 servings, Vitamin B 12 0.5 portions;

[0055] The above raw materials are mixed evenly to obtain the composition.

[0056] Example 2 Preparation of the composition

[0057] Raw material composition by weight: 75 parts of trisodium fructose 1,6-bisphosphate, Coenzyme Q10 10 15 servings, Vitamin E 1 serving, Vitamin B6 0.5 servings, Vitamin B9 2 servings, Vitamin B 12 0.5 portions;

[0058] The above raw materials are mixed evenly to obtain the composition.

[0059] Example 3 Preparation of the composition

[0060] Raw material composition by weight: 60 parts β-nicotinamide mononucleotide, 15 parts trisodium fructose 1,6-bisphosphate, coenzyme Q10 10 15 servings, Vitamin E 1 serving, Vitamin B6 0.5 servings, Vitamin B9 2 servings, Vitamin B 12 0.5 portions;

[0061] The above raw materials are mixed evenly to obtain the composition.

[0062] Example 4 Preparation of the composition

[0063] Raw material composition by weight: 50 parts β-nicotinamide mononucleotide, 10 parts trisodium fructose 1,6-bisphosphate, coenzyme Q10. 10 20 servings, Vitamin E 5 servings, Vitamin B6 0.5 servings, Vitamin B9 2 servings, Vitamin B 12 2 copies;

[0064] The above raw materials are mixed evenly to obtain the composition.

[0065] Example 5 Preparation of the composition

[0066] Raw material composition by weight: 80 parts β-nicotinamide mononucleotide, 20 parts trisodium fructose 1,6-bisphosphate, coenzyme Q. 10 10 servings, Vitamin E 1 serving, Vitamin B6 2 servings, Vitamin B9 5 servings, Vitamin B 12 0.5 portions;

[0067] The above raw materials are mixed evenly to obtain the composition.

[0068] Example 6 Preparation of the composition

[0069] Raw material composition by weight: 60 parts β-nicotinamide mononucleotide, 15 parts trisodium fructose 1,6-bisphosphate, coenzyme Q10 10 15 servings, Vitamin E 1 serving, Vitamin B6 0.5 servings, Vitamin B9 2 servings, Vitamin B 12 0.5 parts; 15 parts of traditional Chinese medicine extract;

[0070] The herbal extract mentioned above is prepared by the following method:

[0071] Take Codonopsis pilosula and Cinnamomum cassia in a weight ratio of 1:1, add an organic solvent equivalent to 10 times the total weight of Codonopsis pilosula and Cinnamomum cassia, and extract by ultrasonication for 30 minutes at 45℃, ultrasonic power of 400W and ultrasonic frequency of 25KHz. After extraction, concentrate and dry the extract to obtain the Chinese herbal extract.

[0072] The organic solvent is composed of ethyl acetate and n-butanol in a volume ratio of 3:2.

[0073] Preparation of the composition of Comparative Example 1

[0074] The raw material composition by weight is the same as in Example 6.

[0075] The herbal extract mentioned above is prepared by the following method:

[0076] Take Codonopsis pilosula and Cinnamomum cassia in a weight ratio of 1:1, add an organic solvent equivalent to 10 times the total weight of Codonopsis pilosula and Cinnamomum cassia, and extract by ultrasonication for 30 minutes at 45℃, ultrasonic power of 400W and ultrasonic frequency of 25KHz. After extraction, concentrate and dry the extract to obtain the Chinese herbal extract.

[0077] The organic solvent is methanol.

[0078] Preparation of the composition of Comparative Example 2

[0079] The raw material composition by weight is the same as in Example 6.

[0080] The herbal extract mentioned above is prepared by the following method:

[0081] Take Codonopsis pilosula and Cinnamomum cassia in a weight ratio of 1:1, add an organic solvent equivalent to 10 times the total weight of Codonopsis pilosula and Cinnamomum cassia, and extract by ultrasonication for 30 minutes at 45℃, ultrasonic power of 400W and ultrasonic frequency of 25KHz. After extraction, concentrate and dry the extract to obtain the Chinese herbal extract.

[0082] The organic solvent is acetone.

[0083] Preparation of the composition of Comparative Example 3

[0084] The raw material composition by weight is the same as in Example 6.

[0085] The herbal extract mentioned above is prepared by the following method:

[0086] Take Codonopsis pilosula and Cinnamomum cassia in a weight ratio of 1:1, add an organic solvent equivalent to 10 times the total weight of Codonopsis pilosula and Cinnamomum cassia, and extract by ultrasonication for 30 minutes at 45℃, ultrasonic power of 400W and ultrasonic frequency of 25KHz. After extraction, concentrate and dry the extract to obtain the Chinese herbal extract.

[0087] The organic solvent is ethyl acetate.

[0088] Preparation of the composition of Comparative Example 4

[0089] The raw material composition by weight is the same as in Example 6.

[0090] The herbal extract mentioned above is prepared by the following method:

[0091] Take Codonopsis pilosula and Cinnamomum cassia in a weight ratio of 1:1, add an organic solvent equivalent to 10 times the total weight of Codonopsis pilosula and Cinnamomum cassia, and extract by ultrasonication for 30 minutes at 45℃, ultrasonic power of 400W and ultrasonic frequency of 25KHz. After extraction, concentrate and dry the extract to obtain the Chinese herbal extract.

[0092] The organic solvent is n-butanol.

[0093] Experimental Example 1

[0094] Methods for establishing a rat model of heart failure: Male SD rats weighing 250±25g were anesthetized and their skin was incised along the 3rd-4th intercostal space on the left side. Subcutaneous tissue and muscle were separated, and the pericardium was opened. Then, the left atrial appendage was lifted with forceps, and the left anterior descending coronary artery was ligated with sutures. The pleural cavity was sutured after ligation. Penicillin was injected to prevent infection. SD rats that survived 15 days of feeding after treatment were used as rats for the heart failure model.

[0095] In addition, the thoracic cavity was opened according to the above method, without ligating the left anterior descending coronary artery, and then the thoracic cavity was sutured and penicillin was injected to prevent infection; SD rats that survived 15 days after being treated according to the above method were used as sham-operated rats.

[0096] One hundred and ten rats with heart failure were used as a model group and experimental groups 1-10, with ten rats in each group. Ten rats treated as described above were used as a sham-operated control group. The experimental group was administered the composition described in Examples 1-6 or Comparative Examples 1-4 by gavage at a dose of 200 mg / kg per day. The model group and the sham-operated control group were administered an equal amount of distilled water by gavage. The drugs were administered by gavage once a day for 30 consecutive days. After that, the left ventricular ejection fraction (EF) and left ventricular fractional shortening (FS) of each group were tested. Each rat was tested three times. The test results are shown in Table 1.

[0097] Table 1.

[0098]

[0099]

[0100] As can be seen from the experimental data in Table 1, compared with the sham-operated control group, the left ventricular ejection fraction (EF) and left ventricular fractional shortening (FS) of the rats in the model group were significantly smaller; this indicates that the rat model of heart failure was successfully established.

[0101] As shown in Table 1, the left ventricular ejection fraction (EF) and left ventricular fractional shortening (FS) of experimental groups 1 and 2 were significantly improved compared with the model group. This indicates that the combination of β-nicotinamide mononucleotide or trisodium 1,6-bisphosphate with coenzyme Q10 and multivitamins has a good effect in preventing or treating heart failure and improving cardiac function.

[0102] As shown in Table 1, the left ventricular ejection fraction (EF) and left ventricular fractional shortening (FS) in experimental group 3 were significantly improved compared to experimental groups 1 and 2, and were much higher than those in the model group. This indicates that the simultaneous application of β-nicotinamide mononucleotide and trisodium 1,6-bisphosphate with coenzyme Q10 is effective. 10 When combined with multivitamins, its effects in preventing or treating heart failure or improving cardiac function are significantly stronger than those of β-nicotinamide mononucleotide or trisodium 1,6-bisphosphate with coenzyme Q alone. 10 A combination with multivitamins. Simultaneously, β-nicotinamide mononucleotide and trisodium 1,6-bisphosphate fructose are combined with coenzyme Q. 10 When combined with multivitamins, it can synergistically enhance the composition's effects in preventing or treating heart failure and improving cardiac function.

[0103] As can be seen from the experimental data in Table 1, the left ventricular ejection fraction (EF) and left ventricular fractional shortening (FS) of experimental group 6 were significantly improved compared with experimental group 3, and were far higher than those of Examples 1 and 2. This indicates that further adding the extract obtained by the method described in this invention using Codonopsis pilosula and cinnamon as raw materials to the composition can further significantly improve the composition's effect in preventing or treating heart failure and improving cardiac function.

[0104] As shown in Table 1, the left ventricular ejection fraction (EF) and left ventricular fractional shortening (FS) in experimental groups 7 and 8 were not improved compared to experimental group 3. While the EF and FS in experimental groups 9 and 10 were improved compared to experimental group 3, the improvement was not significant. This indicates that the degree to which extracts from Codonopsis pilosula and Cinnamomum cassia, obtained using different solvents, enhance the preventive or therapeutic effects of the combination on heart failure and improve cardiac function varies. Not all extracts obtained using any solvent can significantly enhance or improve the preventive or therapeutic effects of the combination on heart failure and improve cardiac function. The experimental data above show that the herbal extracts obtained from Codonopsis pilosula and cinnamon using ethyl acetate and n-butanol significantly enhance the composition's effects on preventing or treating heart failure and improving cardiac function compared to extracts obtained using other organic solvents. Adding these herbal extracts to the composition can substantially improve its effects on preventing or treating heart failure and improving cardiac function, resulting in a composition with excellent effects on preventing or treating heart failure and improving cardiac function.

[0105] Example 7

[0106] 60g of β-nicotinamide mononucleotide, 15g of trisodium fructose 1,6-bisphosphate, and coenzyme Q. 10 15g, Vitamin E 1g, Vitamin B6 0.5g, Vitamin B9 2g, Vitamin B 12 0.5g, microcrystalline cellulose 6g, magnesium stearate 0.5g, silicon dioxide 0.5g.

[0107] Prepare the ingredients according to the recipe proportions, put them into a mixer and mix for 1 hour to ensure thorough mixing.

[0108] After mixing the ingredients, place the capsule shells into the material inlet and capsule filling inlet of the capsule machine, respectively. Turn on the air compressor to fill the material. Use No. 1 capsule shells and fill the capsules with 300mg of material.

[0109] Example 8

[0110] 50g β-nicotinamide mononucleotide, 20g sorbitol, 15g maltodextrin, 10g trisodium fructose 1,6-bisphosphate, coenzyme Q10 10 10g, Vitamin E 1g, Vitamin B6 0.5g, Vitamin B9 2g, Vitamin B 12 0.5g, microcrystalline cellulose 5g, magnesium stearate 0.5g, silicon dioxide 0.5g, sucralose 0.1g.

[0111] Prepare the ingredients according to the formula ratio, put them into the mixer and stir for 1 hour to mix thoroughly. Put the mixture into the feed inlet of the tablet press, adjust the tablet thickness and pressure of the tablet press, so that the final tablet weight is 0.57g.

[0112] Add water to the tank according to the coating agent:water ratio of 1:8, turn on the stirrer, and slowly add the coating agent (ratio: 59% microcrystalline cellulose, 20% hydroxypropyl methylcellulose, 10% sodium crosyl cellulose, 10% polyethylene glycol, 0.5% talc, 0.5% magnesium stearate). Stir for 30 minutes until the coating solution is evenly mixed. Turn on the air compressor and place the resulting tablets in the coating pan for coating. The rotation speed of the coating pan is 12 r / min, the spraying speed is 10 mL / min, and the spraying pressure is 0.4 MPa. The weight gain after coating is about 5%, and the weight of the tablet is 0.60 g.

[0113] Example 9

[0114] 100g whole milk powder, 2g β-nicotinamide mononucleotide, 0.5g trisodium fructose 1,6-bisphosphate, coenzyme Q10 10 0.5g, Vitamin B6 0.1g, Vitamin B9 0.5g, Vitamin B 12 0.1g, microcrystalline cellulose 5g, magnesium stearate 0.1g, silicon dioxide 0.1g.

[0115] Prepare the ingredients according to the formula ratio, put them into the mixer and stir for 1 hour to mix thoroughly. Accurately install the packaging film onto the powder filling machine and bag it in 5g bags.

[0116] The above description is merely a preferred embodiment of the present invention and is not intended to limit the invention. Various modifications and variations can be made to the present invention by those skilled in the art. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the scope of protection of the present invention.

Claims

1. A composition characterized in that, The composition comprises the following components: (1) β - nicotinamide mononucleotide and tri-sodium salt of 1,6-fructose diphosphate, and (2) coenzyme Q 10 and complex vitamins; In the composition β - Nicotinamide mononucleotide, trisodium fructose 1,6-bisphosphate, coenzyme Q 10 The weight portions of the multivitamins are as follows: β - nicotinamide mononucleotide 60 parts, fructose 1,6-bisphosphate trisodium salt 15 parts, coenzyme Q 10 15 parts, complex vitamin 4 parts; The complex vitamin comprises vitamin E, vitamin B6, vitamin B9, and vitamin B 12 one or two or more of the above.

2. The composition of claim 1, wherein, The weight parts of vitamin E, vitamin B6, vitamin B9 and vitamin B 12 in the composition are respectively: Vitamin E 1-5 parts, Vitamin B6 0.5-2 parts, Vitamin B9 2-5 parts, Vitamin B 12 0.5-2 portions.

3. The composition of claim 1, wherein, The composition further comprises a traditional Chinese medicine extract; the traditional Chinese medicine extract is extracted from radix ginseng and cassia.

4. Use of the composition according to any one of claims 1 to 3 for the preparation of a product for the prevention or treatment of heart failure.

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