Preparation method and application of anti-inflammatory drug-l-arginine conjugate and nano preparation thereof

By preparing anti-inflammatory drug-L-arginine conjugates and their nano-formulations, the problems of complex design and immune response risks of existing nanomedicines have been solved, achieving dual regulation and improved therapeutic effects for vascular-related diseases.

CN115920072BActive Publication Date: 2026-02-10SHENYANG PHARMA UNIV
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Patent Information

Application Number
CN202211187522.8
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2022-09-28
Publication Date
2026-02-10
Estimated Expiration
2042-09-28

AI Technical Summary

Technical Problem

Existing nanomedicines for treating vascular-related diseases are complex to design, pose risks of immune response, and lack comprehensive regulation of endothelial dysfunction and inflammation, resulting in poor treatment efficacy.

Method used

We prepared an anti-inflammatory drug-L-arginine conjugate and its nanoformation. The drug was endowed with hydrophilicity through chemical condensation. The polysialic acid-mediated nanoplatform was used to achieve dual regulation of inflammation and endothelial cells, forming a polyionic complex for targeted delivery.

Benefits of technology

It achieves dual regulation of vascular-related diseases, restoring vascular normalization, reducing inflammatory response, improving treatment efficacy, and expanding the spectrum of disease treatment.

✦ Generated by Eureka AI based on patent content.

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Abstract

The application relates to a preparation method and application of an anti-inflammatory drug-l-arginine combination and a nano preparation thereof, and belongs to the technical field of biological medicines, and particularly relates to a preparation method and application of an anti-inflammatory drug-l-arginine combination and a nano preparation thereof. In the anti-inflammatory drug-l-arginine combination, the anti-inflammatory drug containing a hydroxyl group is chemically combined with the l-arginine carrying a carboxyl group through an ester bond, has hydrophilicity and a positive charge, and is beneficial to the preparation of a suitable nano preparation. The nano preparation is self-assembled from the anti-inflammatory drug-l-arginine combination and a polyanion material in a proportion under stirring, the preparation process is simple and easy to industrialize; the nano preparation can be significantly accumulated at a lesion site, can double-regulate inflammation and endothelial function, can effectively treat blood vessel related diseases, and provides a promising strategy for the clinical treatment of blood vessel related diseases.
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Citation Information

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