A method of processing plastic flexible packaging trays for pharmaceutical packaging

Abstract

The application discloses a processing method for preparing plastic soft packaging trays for medicine packaging, and comprises the following steps: material selection treatment of a composite sheet, first dry composite treatment of a semi-finished product composite sheet, cooling treatment of the semi-finished product composite sheet, second dry composite treatment of the composite sheet, cooling treatment of the composite sheet, slitting and packaging treatment of the composite sheet, material selection treatment for preparing a tray cover film, first dry composite treatment of a semi-finished product tray cover film, aging treatment of the semi-finished product tray cover film, second dry composite treatment of the tray cover film, aging treatment of the tray cover film, cooling treatment of the tray cover film, slitting of the composite sheet, and preparation of the plastic soft packaging tray. The plastic soft packaging tray prepared by the processing method can be used for medicine packaging and can significantly prolong the shelf life of the medicine.

Description

Technical Field

[0001] This invention relates to the field of pharmaceutical packaging technology, and in particular to a processing method for preparing plastic flexible packaging trays for pharmaceutical packaging. Background Technology

[0002] Pharmaceutical packaging plays a vital role in protecting drugs, and its ability to preserve drug performance is crucial. Drug quality standards regulate the entire process, from the production and manufacturing of packaging materials, sales and storage, pharmaceutical packaging, transportation and storage, to the final opening and use of the drug. Since the primary function of drugs is to protect and improve human health, the main role of pharmaceutical packaging is to ensure the safety, efficacy, and stability of drugs under various conditions over extended periods.

[0003] Currently, pharmaceutical oral liquid packaging on the market typically uses boxes, which mainly consist of the box body and a lid film on top. Existing pharmaceutical oral liquid packaging boxes are mainly made of single-layer material through vacuum forming, such as using PET, PVC, or PP single-layer sheets directly formed by a vacuum forming machine. Boxes made of single-layer sheets have poor stability. In practical applications, boxes made of single-layer sheets are prone to deformation, breakage, or even delamination under heat or external force, which causes changes in the barrier properties of the single-layer sheet during heat sealing, which is not conducive to the long-term preservation of medicines. The existing box lids are mainly made of single-layer PE film. The heat seal strength between the traditional lid and the box is either too high or too low. When the heat seal strength is too high, the lid is difficult to open, requiring cutting tools to remove it, which is inconvenient for consumers and results in a poor user experience. When the heat seal strength is too low, there is a risk of the seal falling off during transportation, posing a quality risk. Furthermore, existing pharmaceutical oral liquid packaging boxes have poor barrier properties. When the packaging contains pharmaceutical oral liquids, the internal humidity of the box is high. Due to the poor barrier properties between the box and the lid, the medication will diffuse outwards along the concentration gradient, leading to weight loss over time and potentially causing the loss of the active ingredients. Summary of the Invention

[0004] The technical problem this invention aims to solve is to address the existing technical issues by providing a composite sheet material with good stability and vacuum forming properties, obtained by laminating a polyethylene terephthalate film layer, a modified high moisture-barrier PE film layer, and a CPP film layer. This composite sheet material is easy to vacuum form into a composite sheet box, and the multi-layered film layer ensures good stability, preventing deformation, breakage, or delamination under external forces. It is suitable for pharmaceutical packaging, significantly extending the shelf life of medicines. A single-sided coated paper layer / AL foil layer and a PE easy-peel film layer are heat-pressed together to form a composite tray cover film. An automatic packaging machine then attaches the tray cover film to the edge of the composite sheet box to form a sealed plastic flexible packaging tray. The resulting plastic flexible packaging tray has high barrier properties and is easy to peel off. The heat seal strength between the composite sheet box and the top tray cover film is moderate, requiring no tools and allowing for easy removal of the tray cover film. This facilitates the consumption of oral liquid medicines and provides consumers with a good experience.

[0005] To solve the above-mentioned technical problems, the present invention adopts the following technical solution:

[0006] This invention provides a processing method for preparing plastic flexible packaging trays for pharmaceutical packaging, comprising a processing method for preparing plastic flexible packaging trays, wherein the plastic flexible packaging trays are prepared by preparing composite sheet box bodies and tray cover films, and the processing method includes the following processing steps:

[0007] Step 1) Material selection and treatment of composite sheet: A 300μm thick polyethylene terephthalate film layer is selected as the surface layer for preparing the composite sheet, a 60μm thick modified high moisture barrier PE film layer is selected as the double corona layer for preparing the composite sheet, and a 60μm thick CPP film layer is selected as the heat sealing layer for preparing the composite sheet.

[0008] Step 2) First Dry Lamination Treatment of Semi-finished Composite Sheets: The 60μm thick modified high moisture-barrier PE film layer selected in Step 1) is loaded onto the first feeding guide roller group of the dry laminating machine. Simultaneously, the selected 300μm thick polyethylene terephthalate film layer is loaded onto the second feeding guide roller group of the dry laminating machine. The first feeding guide roller group of the dry laminating machine feeds the 60μm thick modified high moisture-barrier PE film layer into the coating system. The modified high moisture-barrier PE film layer passes through the coating rollers and pressure rollers of the coating system. Under the action of the coating rollers and pressure rollers, the first two-component polyurethane adhesive is applied to the inner surface of the treated surface of the modified high moisture-barrier PE film layer. Then, the modified high moisture-barrier PE film layer is sent into the drying oven for further drying. The three drying tunnels of the dry oven heat the solvent of the first two-component polyurethane adhesive on the modified high moisture barrier PE film to evaporate it. The temperatures of the three drying tunnels are set to 60℃, 70℃ and 80℃ respectively. After drying, the modified high moisture barrier PE film reaches the pressure roller and hot steel roller along the guide roller group. The 300μm thick polyethylene terephthalate film is fed to the pressure roller and hot steel roller by the second feeding guide roller group of the dry laminating machine. Under the hot pressing action of the pressure roller and hot steel roller, the polyethylene terephthalate film and the modified high moisture barrier PE film coated with the first two-component polyurethane adhesive are hot-pressed together to form a composite polyethylene terephthalate film / modified high moisture barrier PE film semi-finished composite sheet.

[0009] Step 3) Cooling treatment of semi-finished composite sheet: The semi-finished composite sheet of polyethylene terephthalate film layer / modified high moisture barrier PE film layer obtained after step 2) is fed to the cooling roller along the guide roller group for room temperature cooling. The room temperature cooling time is not less than 12 hours. After cooling, the semi-finished composite sheet of polyethylene terephthalate film layer / modified high moisture barrier PE film layer is wound up by the winding guide roller.

[0010] Step 4) Second Dry Lamination Treatment of Composite Sheets: The 60μm thick CPP film layer selected in Step 1) is loaded onto the first feeding guide roller group of the dry laminating machine. Simultaneously, the semi-finished composite sheet of polyethylene terephthalate film layer / modified high moisture-barrier PE film layer (from Step 3) is loaded onto the second feeding guide roller group of the dry laminating machine. The 60μm thick CPP film layer is fed to the coating system via the first feeding guide roller group. The CPP film layer passes through the coating rollers and pressure rollers of the coating system. Under the action of the coating rollers and pressure rollers, a second two-component polyurethane adhesive is applied to the inner surface of the CPP film layer. The CPP film layer is then sent to the drying oven, where it passes through three drying tunnels to further dry the CPP film layer. The solvent of the two-component polyurethane adhesive is heated to evaporate. The temperatures of the three drying tunnels are set to 60℃, 70℃, and 80℃, respectively. After drying, the CPP film layer reaches the pressure roller and hot steel roller along the guide roller group. At the same time, the second feeding guide roller group of the dry laminating machine will send the semi-finished composite sheet of polyethylene terephthalate film layer / modified high moisture barrier PE film layer to the pressure roller and hot steel roller. Under the hot pressing action of the pressure roller and hot steel roller, the semi-finished composite sheet of polyethylene terephthalate film layer / modified high moisture barrier PE film layer and the CPP film layer coated with the second two-component polyurethane adhesive are hot-pressed together to form a composite sheet of polyethylene terephthalate film layer / modified high moisture barrier PE film layer / CPP film layer.

[0011] Step 5) Cooling treatment of composite sheet: The composite sheet of polyethylene terephthalate film / modified high moisture barrier PE film / CPP film obtained after step 4) is fed to the cooling roller along the guide roller group for room temperature cooling. The room temperature cooling time is not less than 72 hours. After cooling, the composite sheet of polyethylene terephthalate film / modified high moisture barrier PE film / CPP film is wound up by the winding guide roller.

[0012] Step 6) Slitting and packaging of composite sheet: The edges of the composite sheet after curing in step 5) are cut off by a slitting machine, and the composite sheet is slitting into blister composite sheets for pharmaceutical packaging, and then packaged.

[0013] Step 7) Material selection for pallet cover film preparation: After the composite sheet is packaged, select a 40g single-sided coated paper layer as the printing layer of the pallet cover film, select a 9μm thick AL foil layer as the intermediate barrier layer of the pallet cover film, and select a 50μm thick PE easy-peel film layer as the inner heat-sealing layer of the pallet cover film.

[0014] To further improve the above technical solution, the processing method further includes the following processing steps:

[0015] Step 8) First dry lamination treatment of the semi-finished pallet cover film: The 9μm thick AL foil layer selected in Step 7) is loaded onto the first unwinding guide roller group of the laminating machine, and the selected 40g single-sided coated paper layer is loaded onto the second unwinding guide roller group of the laminating machine. The 9μm thick AL foil layer is fed into the gluing system through the first unwinding guide roller group of the laminating machine. The AL foil layer passes through the coating roller and pressure roller of the gluing system. Under the action of the coating roller and pressure roller, the first coat of two-component polyurethane adhesive is applied to the inner surface of the treated surface of the AL foil layer. Then the AL foil layer is sent into the drying oven and undergoes three drying stages in the oven. The solvent of the first two-component polyurethane adhesive is heated to evaporate. The temperatures of the three drying tunnels are set to 50℃, 60℃, and 70℃, respectively. After drying, the AL foil layer is pulled along the guide roller to the pressing guide roller and the hot steel guide roller. At the same time, the second unwinding guide roller group of the laminating machine feeds 40g of single-sided coated paper layer to the pressing guide roller and the hot steel guide roller. Under the hot pressing action of the pressing guide roller and the hot steel guide roller, the single-sided coated paper layer and the AL foil layer coated with the first two-component polyurethane adhesive are hot-pressed together to form a composite single-sided coated paper layer / AL foil layer semi-finished tray cover film, which is then wound up by the winding roller.

[0016] Step 9) Curing treatment of semi-finished pallet cover film: The semi-finished pallet cover film with single-sided coated paper layer / AL foil layer obtained after step 8) is sent into the curing chamber for curing. The curing temperature is 45℃ and the curing time is 36h.

[0017] Step 10) Second Dry Lamination Treatment of Pallet Cover Film: The semi-finished pallet cover film with single-sided coated paper / AL foil layer (prepared in Step 9) is loaded onto the first unwinding guide roller group of the laminating machine. The 50μm thick PE easy-peel film layer selected in Step 7) is loaded onto the second unwinding guide roller group of the laminating machine. The first unwinding guide roller group of the laminating machine feeds the semi-finished pallet cover film with single-sided coated paper / AL foil layer into the gluing system. The semi-finished pallet cover film with single-sided coated paper / AL foil layer passes through the coating rollers and pressure rollers of the gluing system. Under the action of the coating rollers and pressure rollers, a second coat of two-component polyurethane adhesive is applied to the semi-finished pallet cover film with single-sided coated paper / AL foil layer. Then, the semi-finished pallet cover film with single-sided coated paper / AL foil layer is sent into the drying oven for further processing. The three drying tunnels of the oven heat the solvent of the second two-component polyurethane adhesive on the semi-finished pallet cover film with a single-sided coated paper / AL foil layer to evaporate it. The temperatures of the three drying tunnels are set to 50℃, 60℃, and 70℃, respectively. After drying, the semi-finished pallet cover film with a single-sided coated paper / AL foil layer is pulled along the guide rollers to the pressure rollers and hot steel rollers. At the same time, the second unwinding guide roller group of the laminating machine sends the PE easy-peel film layer to the pressing guide rollers and hot steel rollers. Under the hot pressing action of the pressing guide rollers and hot steel rollers, the PE easy-peel film layer and the semi-finished pallet cover film with a single-sided coated paper / AL foil layer coated with the second two-component polyurethane adhesive layer are hot-pressed and bonded together to form a composite pallet cover film with a single-sided coated paper / AL foil layer / PE easy-peel film layer, which is then wound up by the winding rollers.

[0018] Step 11) Curing treatment of tray cover film: The tray cover film with single-sided coated paper layer / AL foil layer / PE easy-peel film layer obtained after step 8) is sent into the curing chamber for curing. The curing temperature is 45℃ and the curing time is 36h.

[0019] Step 12) Cooling treatment of tray cover film: The tray cover film with single-sided coated paper layer / AL foil layer / PE easy-peel film layer obtained after curing in step 11) is cooled at room temperature for 24 hours.

[0020] Step 13) Slitting of composite sheet: Slit the cooled pallet cover film from step 12) into pallet cover films that match the size of the composite sheet, and pack them into the warehouse;

[0021] Step 14) Prepare a plastic flexible packaging tray: According to the required shape of the medicine packaging, the composite sheet is vacuum-formed into a composite sheet box, then the medicine is filled into the composite sheet box, and then the tray cover film is attached to the edge of the composite sheet box by an automatic packaging machine to form a sealed plastic flexible packaging tray.

[0022] To further improve the above technical solution, the first and second two-component polyurethane adhesives used in steps 2) and 4) are two-component polyurethane adhesives of model "XH-66F / XH-K75". The raw material composition and ratio of the two-component polyurethane adhesive are: main agent XH-66F: curing agent XH-K75: ethyl acetate solvent = 20:3.0:30.9. The working solution concentration of the two-component polyurethane adhesive is 25-32%, and the viscosity of the two-component polyurethane adhesive is 15±2 Pascals per second. The viscosity of the two-component polyurethane adhesive is measured at 25°C using a #3 Zahn cup at the working solution concentration (25-32%). The coating roller used in steps 2) and 4) has a 140*55 gravure screen, and the coating amount is 2.2 g / m². 2 .

[0023] To further improve the above technical solution, in step 2), the tension required for the first unwinding guide roller group of the dry laminating machine to unwind the modified high moisture-resistant PE film layer is 5 kgf, and the tension required for the second unwinding guide roller group of the dry laminating machine to unwind the polyethylene terephthalate film layer is 23 kgf; in step 4), the tension required for the first unwinding guide roller group of the dry laminating machine to unwind the CPP film layer is 4 kgf, and the tension required for the second unwinding guide roller group of the dry laminating machine to unwind the polyethylene terephthalate film layer / modified high moisture-resistant PE film layer semi-finished composite sheet is 25 kgf; the speed of the pressure roller and hot steel roller used in steps 2) and 4) for hot pressing lamination is 60 m / min; and the winding tension of the winding guide roller in steps 3) and 5) is 25 kgf.

[0024] To further improve the above technical solution, the first and second two-component polyurethane adhesives used in steps 8) and 10) are of model "XH-66F / XH-K75". The raw material composition and ratio of the two-component polyurethane adhesive are: main agent XH-66F: curing agent XH-K75: ethyl acetate solvent = 20:3.8:26. The working solution concentration of the two-component polyurethane adhesive is 25-32%, and the viscosity of the two-component polyurethane adhesive is 15±2 Pascals per second. The viscosity of the two-component polyurethane adhesive is measured at 25°C using a #3 Zahn cup at the working solution concentration (25-32%). The coating roller used in steps 8) and 10) has a 110*70 gravure screen, and the coating amount is 3.2 g / m². 2 .

[0025] To further improve the above technical solution, in step 8), the tension required for the first unwinding guide roller group of the laminating machine to unwind the AL foil layer is 12 kgf, the tension required for the second unwinding guide roller group of the laminating machine to unwind the single-sided coated paper layer is 20 kgf, the tension required for the first unwinding guide roller group of the laminating machine to unwind the semi-finished pallet cover film of the single-sided coated paper layer / AL foil layer in step 10) is 20 kgf, the tension required for the second unwinding guide roller group of the laminating machine to unwind the PE easy-peel film layer is 4 gf, the speed of the pressing guide roller and hot steel guide roller used in steps 8) and 10) for hot pressing lamination is 90 m / min, and the winding tension of the winding roller in steps 8) and 10) is 28 kgf.

[0026] To further improve the above technical solution, the modified high moisture-resistant PE film layer in step 1) is made of a first layer A particle layer, a second layer B particle layer, and a third layer C particle layer. The first layer A particle layer accounts for 30%, the first layer B particle layer accounts for 40%, and the third layer C particle layer accounts for 30%. The first layer A particle layer is composed of 100% linear medium-density polyethylene resin. The first layer B particle layer is composed of 80-85% low-pressure high-density polyethylene resin and 15-20% high-pressure low-density polyethylene resin. The third layer C particle layer is composed of 80-85% medium-density metallocene, 10-15% high-pressure low-density polyethylene resin, 0.5-2% opening agent, and 0.5-2% slip agent.

[0027] To further improve the above technical solution, the preparation of the modified high moisture-resistance PE film layer in step 1) includes the following steps:

[0028] Step 11) Weigh each component according to the percentage of each particle layer in the modified high moisture barrier PE film layer and mix them. Then add them to the three barrels of the extruder to obtain the mixture of the first A layer particle layer, the second B layer particle layer and the third C layer particle layer respectively.

[0029] Step 12) The mixture in the three barrels of Step 11) is melted at high temperature through the high temperature heating and melting device of the extruder to form a tube blank. The temperature required for high temperature melting is 180-300℃.

[0030] Step 13) After stretching the tube blank, it is extruded from the center of the extruder die and compressed with air, causing the tube blank to inflate into a film bubble. At the same time, the film bubble is cooled and shaped by the air ring to obtain a film.

[0031] Step 14) The film prepared in Step 13) is fed into an aluminizing machine for double corona vacuum evaporation. The modified high moisture barrier PE film is obtained after double corona vacuum evaporation. The water vapor transmission rate of the prepared modified high moisture barrier PE film is 0.6~0.9 g / (m²). 2•24h).

[0032] To further improve the above technical solution, the PE easy-peel film layer mentioned in step 7) is prepared by co-extrusion of four layers: corona layer, intermediate layer, bonding layer and heat-sealing layer. The corona layer accounts for 30%, the intermediate layer accounts for 30%, the bonding layer accounts for 20%, and the heat-sealing layer accounts for 20%.

[0033] To further improve the above technical solution, the corona layer of the PE easy-peel film is composed of 70-75% ethylene and 20%-30% propylene binary copolymer, the intermediate layer is made of 100% polypropylene, the bonding layer is made of 25-35% metallocene polypropylene, 20-30% metallocene polyethylene, and 30-40% butene terpolymer polypropylene, and the heat-sealing layer is made of 30-40% low-density polyethylene and 70-60% low-crystallinity α-olefin copolymer. The materials corresponding to each layer of the corona layer, intermediate layer, bonding layer and heat-sealing layer are added to an extruder for heating and melting. The melted materials are then co-extruded, blown and cooled, and drawn and shaped to obtain the PE easy-peel film.

[0034] Compared with the prior art, the solution of the present invention has at least the following beneficial effects:

[0035] The processing steps for preparing a plastic flexible packaging tray according to this invention include: material selection and treatment of composite sheets; first dry lamination treatment of semi-finished composite sheets; cooling treatment of semi-finished composite sheets; second dry lamination treatment of composite sheets; cooling treatment of composite sheets; slitting and packaging treatment of composite sheets; material selection and treatment for preparing tray cover film; first dry lamination treatment of semi-finished tray cover film; curing treatment of semi-finished tray cover film; second dry lamination treatment of tray cover film; curing treatment of tray cover film; cooling treatment of tray cover film; slitting of composite sheets; preparation into a plastic flexible packaging tray; thermoforming the composite sheets into a composite sheet box according to the required shape for drug packaging; filling the composite sheet box with drugs; and then using an automatic packaging machine to attach the tray cover film to the edge of the composite sheet box to form a sealed plastic flexible packaging tray. The processing method of this invention can modify high-moisture-barrier PE film, polyethylene terephthalate film, and CPP film to obtain a composite sheet with good vacuum forming properties. This facilitates the vacuum forming of the composite sheet into a composite sheet box. Furthermore, the composite sheet obtained by using multiple film layers exhibits good stability, preventing deformation, breakage, or delamination under external forces. It is suitable for pharmaceutical packaging and can significantly extend the shelf life of medicines. The processing method of this invention can also heat-press a single-sided coated paper layer, an AL foil layer, and a PE easy-peel film layer to form a composite tray cover film. An automatic packaging machine then adheres the tray cover film to the edge of the composite sheet box to form a sealed plastic flexible packaging tray. The resulting plastic flexible packaging tray has high barrier properties and is easy to peel off. The heat seal strength between the processed composite sheet box and the top tray cover film is moderate, allowing the tray cover film to be peeled off without tools. This facilitates the consumption of oral liquid medicines and provides consumers with a good experience.

[0036] (2) The modified high moisture barrier PE film of the present invention is made of a first layer A, a second layer B, and a third layer C. The proportions of each layer are weighed and mixed, then added to the three barrels of an extruder to obtain mixtures of the first layer A, the second layer B, and the third layer C. The mixtures in the three barrels are then melted at high temperature using the extruder's high-temperature heating and melting device to form a tube blank. The tube blank is then stretched and extruded from the center of the extruder die while compressed air is used to inflate it into a film bubble. Simultaneously, the film bubble is cooled and shaped by an air ring to obtain a film. Finally, the film is fed into an aluminizing machine for double corona vacuum evaporation. The modified high moisture barrier PE film obtained after double corona vacuum evaporation is 0.6~0.9 g / (m²). 2Compared to ordinary linear low-density polyethylene (LDPE), the modified high-moisture-barrier PE film (24h) has a higher high-pressure LDPE content and can achieve higher crystallinity under stress, resulting in a smaller free volume fraction and a higher glass transition temperature To of the polymer molecules. g Increase the water vapor permeability to improve the barrier properties of the material. The water vapor permeability of conventional PE films is 2.0~4.0 g / (m²). 2 After 24 hours, the water vapor transmission rate of the modified high moisture-barrier PE was 0.6~0.9 g / (m²). 2 (24h), the composite sheet obtained by the present invention after laminating with a modified high moisture barrier PE film layer can greatly improve the barrier properties of the composite sheet. Attached Figure Description

[0037] Figure 1 This is a schematic diagram of the processing flow for preparing the plastic flexible packaging tray according to the present invention;

[0038] Figure 2 This is a schematic diagram of the composite layer structure used in preparing the composite sheet of the present invention;

[0039] Figure 3 A schematic diagram of the composite layer structure used in preparing the tray cover film of this invention;

[0040] Figure 4 This is a structural diagram of the composite sheet box body and tray cover film seal of the present invention;

[0041] Figure 5 This is a schematic diagram of the first dry lamination process for preparing the semi-finished composite sheet according to the present invention.

[0042] Figure 6 This is a schematic diagram illustrating the second dry lamination process for preparing the composite sheet according to the present invention.

[0043] Figure 7 This is a schematic diagram of the first dry lamination process for preparing the semi-finished tray cover film according to the present invention.

[0044] Figure 8 This is a schematic diagram of the second dry lamination process for preparing the tray cover film according to the present invention.

[0045] In the diagram, the components are: composite sheet 1, first feeding guide roller group 3, second feeding guide roller group 4, guide roller group 5, coating roller 6, pressure roller 7, drying box 8, pressure roller 9, hot steel roller 10, cooling roller 101, winding guide roller 102, semi-finished composite sheet 103, polyethylene terephthalate film 11, first two-component polyurethane adhesive 12, modified high moisture barrier PE film 13, second two-component polyurethane adhesive 14, and CPP film 1. 5. Pallet cover film; 2. Single-sided coated paper layer; 21. First two-component polyurethane adhesive; 22. AL foil layer; 23. Second two-component polyurethane adhesive; 24. PE easy-peel film layer; 25. First unwinding guide roller group; 26. Second unwinding guide roller group; 27. Guide roller; 28. Coating roller; 29. ​​Pressure roller; 30. Oven; 31. Pressing guide roller; 32. Hot steel guide roller; 33. Rewinding roller; 34. Semi-finished pallet cover film; 35. Composite sheet box body; 100. Detailed Implementation

[0046] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0047] like Figure 1-8 As shown, the present invention provides a processing method for preparing a plastic flexible packaging tray for pharmaceutical packaging, including a processing method for preparing the plastic flexible packaging tray, wherein the plastic flexible packaging tray is prepared by preparing a composite sheet box 100 and a tray cover film 2, and the processing method includes the following processing steps:

[0048] Step 1) Material selection and treatment of composite sheet 1: A 300μm thick polyethylene terephthalate film layer 11 is selected as the surface layer for preparing composite sheet 1, a 60μm thick modified high moisture barrier PE film layer 13 is selected as the double corona layer for preparing composite sheet 1, and a 60μm thick CPP film layer 15 is selected as the heat sealing layer for preparing composite sheet 1.

[0049] Step 2) First dry lamination treatment of semi-finished composite sheet 103: The 60μm thick modified high moisture barrier PE film layer 13 selected in Step 1) is loaded onto the first feeding guide roller group 3 of the dry laminating machine. At the same time, the selected 300μm thick polyethylene terephthalate film layer 11 is loaded onto the second feeding guide roller group 4 of the dry laminating machine. The first feeding guide roller group 3 of the dry laminating machine feeds the 60μm thick modified high moisture barrier PE film layer 13 into the coating system. The modified high moisture barrier PE film layer 13 passes through the coating roller 6 and pressure roller 7 of the coating system. Under the action of the coating roller 6 and pressure roller 7, the first two-component polyurethane adhesive 12 is coated on the inner surface of the treated surface of the modified high moisture barrier PE film layer 13. Then the modified high moisture barrier PE film layer 13 is sent into the drying oven 8. After passing through the three drying channels of the drying oven 8, the modified high moisture barrier PE film layer 13 is further processed. The solvent of the first two-component polyurethane adhesive 12 on the PE film layer 13 is heated to evaporate it, and the residual solvent of the first two-component polyurethane adhesive 12 is dried. The temperatures of the three drying tunnels are set to 60℃, 70℃ and 80℃ respectively. After drying, the modified high moisture barrier PE film layer 13 reaches the pressure roller 9 and hot steel roller 10 along the guide roller group 5. The 300μm thick polyethylene terephthalate film layer 11 is fed to the pressure roller 9 and hot steel roller 10 through the second feeding guide roller group 4 of the dry laminating machine. Under the hot pressing action of the pressure roller 9 and hot steel roller 10, the polyethylene terephthalate film layer 11 and the modified high moisture barrier PE film layer 13 coated with the first two-component polyurethane adhesive 12 are hot-pressed together to form the semi-finished composite sheet 103 of polyethylene terephthalate film layer 11 / modified high moisture barrier PE film layer 13.

[0050] Step 3) Cooling treatment of semi-finished composite sheet 103: The semi-finished composite sheet 103 of polyethylene terephthalate film layer 11 / modified high moisture barrier PE film layer 13 obtained after step 2) is fed to cooling roller 101 along guide roller group 5 for room temperature cooling. The room temperature cooling time is not less than 12 hours. After cooling, the semi-finished composite sheet 103 of polyethylene terephthalate film layer 11 / modified high moisture barrier PE film layer 13 is wound up by winding guide roller 102.

[0051] Step 4) Second dry lamination treatment of composite sheet 1: The 60μm thick CPP film layer 15 selected in Step 1) is loaded onto the first feeding guide roller group 3 of the dry laminating machine. At the same time, the semi-finished composite sheet 103 of polyethylene terephthalate film layer 11 / modified high moisture barrier PE film layer 13 after cooling in Step 3) is loaded onto the second feeding guide roller group 4 of the dry laminating machine. The 60μm thick CPP film layer 15 is sent to the coating system through the first feeding guide roller group 3 of the dry laminating machine. The CPP film layer 15 passes through the coating roller 6 and pressure roller 7 of the coating system. Under the action of the coating roller 6 and pressure roller 7, the second two-component polyurethane adhesive 14 is coated on the inner surface of the treated surface of the CPP film layer 15. Then the CPP film layer 15 is sent into the drying oven 8. The second two-component polyurethane adhesive 14 on the CPP film layer 15 is coated through the three drying channels of the drying oven 8. The solvent of polyurethane adhesive 14 is heated to evaporate. The temperatures of the three drying tunnels are set to 60°C, 70°C, and 80°C, respectively. After drying, the CPP film layer 15 reaches the pressure roller 9 and hot steel roller 10 along the guide roller group 5. At the same time, the second feeding guide roller group 4 of the dry laminating machine will send the semi-finished composite sheet 103 of polyethylene terephthalate film layer 11 / modified high moisture barrier PE film layer 13 to the pressure roller 9 and hot steel roller 10. Under the hot pressing action of the pressure roller 9 and hot steel roller 10, the semi-finished composite sheet 103 of polyethylene terephthalate film layer 11 / modified high moisture barrier PE film layer 13 and the CPP film layer 15 coated with the second two-component polyurethane adhesive 14 are hot-pressed together to form a composite sheet 1 of polyethylene terephthalate film layer 11 / modified high moisture barrier PE film layer 13 / CPP film layer 15.

[0052] Step 5) Cooling treatment of composite sheet 1: The composite sheet 1 obtained after step 4) of polyethylene terephthalate film layer 11 / modified high moisture barrier PE film layer 13 / CPP film layer 15 is fed to cooling roller 101 along guide roller group 5 for room temperature cooling. The room temperature cooling time is not less than 72 hours. After cooling, the composite sheet 1 of polyethylene terephthalate film layer 11 / modified high moisture barrier PE film layer 13 / CPP film layer 15 is wound up by winding guide roller 102.

[0053] Step 6) Slitting and packaging of composite sheet 1: The edges of the composite sheet 1 after curing in step 5) are cut off by a slitting machine, and the composite sheet 1 is slitting into blister composite sheets for pharmaceutical packaging, and then packaged.

[0054] Step 7) Material selection for the preparation of tray cover film 2: After the composite sheet 1 is packaged, a 40g single-sided coated paper layer 21 is selected as the printing layer of tray cover film 2, a 9μm thick AL foil layer 23 is selected as the intermediate barrier layer of tray cover film 2, and a 50μm thick PE easy-peel film layer 25 is selected as the inner heat-sealing layer of tray cover film 2.

[0055] Step 8) First dry lamination treatment of semi-finished pallet cover film 35: The 9μm thick AL foil layer 23 selected in step 7) is loaded onto the first unwinding guide roller group 26 of the laminating machine, and the selected 40g single-sided coated paper layer 21 is loaded onto the second unwinding guide roller group 27 of the laminating machine. The 9μm thick AL foil layer 23 is fed into the gluing system through the first unwinding guide roller group 26 of the laminating machine. The AL foil layer 23 passes through the coating roller 29 and the pressure roller 30 of the gluing system. Under the action of the coating roller 29 and the pressure roller 30, the first coat of two-component polyurethane adhesive 22 is applied to the inner surface of the treated surface of the AL foil layer 23. Then the AL foil layer 23 is sent into the drying oven 31 and undergoes three drying passes in the drying oven 31 to dry the AL foil layer 23. The solvent of the first two-component polyurethane adhesive 22 is heated to evaporate. The temperatures of the three drying tunnels are set to 50℃, 60℃, and 70℃, respectively. After drying, the AL foil layer 23 is pulled along the guide roller 28 to the pressing guide roller 32 and the hot steel guide roller 33. At the same time, the second unwinding guide roller group 27 of the laminating machine feeds 40g of single-sided coated paper layer 21 to the pressing guide roller 32 and the hot steel guide roller 33. Under the hot pressing action of the pressing guide roller 32 and the hot steel guide roller 33, the single-sided coated paper layer 21 and the AL foil layer 23 coated with the first two-component polyurethane adhesive 22 are hot-pressed together to form a composite single-sided coated paper layer 21 / AL foil layer 23 semi-finished tray cover film 35, which is then wound up by the winding roller 34.

[0056] Step 9) Curing treatment of semi-finished pallet cover film 35: The semi-finished pallet cover film 35 with single-sided coated paper layer 21 / AL foil layer 23 obtained after step 8) is sent into the curing chamber for curing. The curing temperature is 45℃ and the curing time is 36h, so as to prevent the semi-finished pallet cover film 35 with single-sided coated paper layer 21 / AL foil layer 23 from wrinkling.

[0057] Step 10) Second dry lamination treatment of tray cover film 2: The semi-finished tray cover film 35 with single-sided coated paper layer 21 / AL foil layer 23 after curing in step 9) is loaded onto the first unwinding guide roller group 26 of the laminating machine. The 50μm thick PE easy-peel film layer 25 selected in step 7) is loaded onto the second unwinding guide roller group 27 of the laminating machine. The first unwinding guide roller group 26 of the laminating machine loads the semi-finished tray cover film 35 with single-sided coated paper layer 21 / AL foil layer 23. The semi-finished pallet cover film 35, with a single-sided paper layer 21 and an AL foil layer 23, is fed into the gluing system. It passes through the gluing roller 29 and the pressure roller 30. Under the action of the gluing roller 29 and the pressure roller 30, a second layer of two-component polyurethane adhesive 24 is applied to the single-sided coated paper layer 21 / AL foil layer 23 semi-finished pallet cover film 35. Then, the single-sided coated paper layer 21 / AL foil layer 23 semi-finished pallet cover film 35 is sent into the drying oven 31, where it undergoes further processing. The three drying tunnels of the oven 31 heat the solvent of the second two-component polyurethane adhesive 24 on the semi-finished tray cover film 35 of the single-sided coated paper layer 21 / AL foil layer 23 to evaporate it. The temperatures of the three drying tunnels are set to 50℃, 60℃, and 70℃ respectively. After drying, the semi-finished tray cover film 35 of the single-sided coated paper layer 21 / AL foil layer 23 is drawn along the guide rollers to the pressure roller 9 and the hot steel roller 10. At the same time, the second unwinding guide roller group 27 of the laminating machine... The PE easy-peel film layer 25 is fed to the pressing guide roller 32 and the hot steel guide roller 33. Under the hot pressing action of the pressing guide roller 32 and the hot steel guide roller 33, the PE easy-peel film layer 25 and the semi-finished pallet cover film 35 with a single-sided coated paper layer 21 / AL foil layer 23 coated with a second layer of two-component polyurethane adhesive 24 are hot-pressed together to form a composite pallet cover film 2 with a single-sided coated paper layer 21 / AL foil layer 23 / PE easy-peel film layer 25, which is then wound up by the winding roller 34.

[0058] Step 11) Curing treatment of tray cover film 2: The tray cover film 2 with single-sided coated paper layer 21 / AL foil layer 23 / PE easy-peel film layer 25 obtained after step 8) is sent into the curing chamber for curing. The curing temperature is 45℃ and the curing time is 36h.

[0059] Step 12) Cooling treatment of tray cover film 2: The tray cover film 2 with single-sided coated paper layer 21 / AL foil layer 23 / PE easy-peel film layer 25 obtained after curing in step 11) is cooled at room temperature for 24 hours.

[0060] Step 13) Slitting of composite sheet 1: Slit the cooled tray cover film 2 from step 12) into tray cover films 2 that match the size of composite sheet 1, and pack them into the warehouse;

[0061] Step 14) Prepare a plastic flexible packaging tray: According to the required shape of the medicine packaging, the composite sheet 1 is vacuum-formed into a composite sheet box 100, then the medicine is filled into the composite sheet box 100, and then the tray cover film 2 is attached to the edge of the composite sheet box 100 by an automatic packaging machine to form a sealed plastic flexible packaging tray.

[0062] This invention selects polyethylene terephthalate film layer 11 as the surface layer for preparing composite sheet 1. Polyethylene terephthalate film layer 11 is abbreviated as APET. Polyethylene terephthalate film layer 11 is a thermoforming material, a thermoplastic environmentally friendly plastic product. Its scraps and waste are recyclable. Its chemical elements are the same as paper, namely carbon, hydrogen and oxygen. It is a biodegradable plastic. After the composite sheet 1 made of this material is discarded, it will eventually decompose into water and carbon dioxide. Polyethylene terephthalate film layer 11 as the surface layer for preparing composite sheet 1 has the characteristics of safety and hygiene, high hardness, and being conducive to thermoforming.

[0063] The processing method of the present invention selects CPP film layer 15 as the heat-sealing layer for preparing composite sheet 1, so that the composite sheet box 100 obtained after preparation can be heat-sealed and bonded with tray cover film 2.

[0064] The processing method of this invention selects single-sided coated paper as the printing layer of the tray cover film 2 because single-sided coated paper has good printability and paper fiber effect. As the printing layer of the composite material of tray cover film 2, it can make the tray cover film 2 obtained after preparation have a rich sense of structure and a high-end feel.

[0065] The processing method of this invention selects AL foil layer 23 as the intermediate barrier layer of tray cover film 2, which has excellent barrier properties, light-blocking properties, and metallic luster. As the intermediate barrier layer of the composite material of tray cover film 2, it can make the tray cover film 2 obtained after preparation have texture and beauty.

[0066] In the specific implementation of this invention, the first two-component polyurethane adhesive 12 and the second two-component polyurethane adhesive 14 used in steps 2) and 4) are two-component polyurethane adhesives of model "XH-66F / XH-K75". The raw material composition and ratio of the two-component polyurethane adhesive are: main agent XH-66F: curing agent XH-K75: ethyl acetate solvent = 20:3.0:30.9. The working solution concentration of the two-component polyurethane adhesive is 25-32%, and the viscosity of the two-component polyurethane adhesive is 15±2 Pascals per second. The viscosity of the two-component polyurethane adhesive is measured at 25°C using a #3 Zahn cup at the working solution concentration (25-32%). The coating roller 6 used for gluing in steps 2) and 4) has a 140*55 gravure screen, and the coating amount is 2.2 g / m. 2In step 2), the tension required for the first unwinding guide roller group 3 of the dry laminator to unwind the modified high moisture-resistant PE film layer 13 is 5 kgf, and the tension required for the second unwinding guide roller group 4 of the dry laminator to unwind the polyethylene terephthalate film layer 11 is 23 kgf. In step 4), the tension required for the first unwinding guide roller group 3 of the dry laminator to unwind the CPP film layer 15 is 4 kgf, and the tension required for the second unwinding guide roller group 4 of the dry laminator to unwind the semi-finished composite sheet 103 of polyethylene terephthalate film layer 11 / modified high moisture-resistant PE film layer 13 is 25 kgf. The speed of the pressure roller 9 and hot steel roller 10 used in steps 2) and 4) for hot pressing is 60 m / min. The winding tension of the winding guide roller 102 in steps 3) and 5) is 25 kgf.

[0067] In specific implementation, the first two-component polyurethane adhesive 22 and the second two-component polyurethane adhesive 24 used in steps 8) and 10) are two-component polyurethane adhesives of model "XH-66F / XH-K75". The raw material composition and ratio of the two-component polyurethane adhesive are: main agent XH-66F: curing agent XH-K75: ethyl acetate solvent = 20:3.8:26. The working solution concentration of the two-component polyurethane adhesive is 25-32%, and the viscosity of the two-component polyurethane adhesive is 15±2 Pascals per second. The viscosity of the two-component polyurethane adhesive is measured at 25°C using a #3 Zahn cup at the working solution concentration (25-32%). The coating roller 29 used in steps 8) and 10) has a coating mesh of 110*70 gravure screen roller, and the coating amount is 3.2 g / m². 2 In step 8), the tension required for the first unwinding guide roller group 26 of the laminating machine to unwind the AL foil layer 23 is 12 kgf, and the tension required for the second unwinding guide roller group 27 of the laminating machine to unwind the single-sided coated paper layer 21 is 20 kgf. In step 10), the tension required for the first unwinding guide roller group 26 of the laminating machine to unwind the semi-finished pallet cover film 35 of the single-sided coated paper layer 21 / AL foil layer 23 is 20 kgf, and the tension required for the second unwinding guide roller group 27 of the laminating machine to unwind the PE easy-peel film layer 25 is 4 gf. The speed of the press guide roller 32 and hot steel guide roller 33 used in steps 8) and 10) for hot pressing lamination is 90 m / min. The winding tension of the take-up roller 34 in steps 8) and 10) is 28 kgf.

[0068] In a specific implementation of this invention, the modified high moisture-resistant PE film layer 13 in step 1) is made of a first layer A particle layer, a second layer B particle layer, and a third layer C particle layer. The first layer A particle layer accounts for 30%, the first layer B particle layer accounts for 40%, and the third layer C particle layer accounts for 30%. The first layer A particle layer is composed of 100% linear medium-density polyethylene resin. The first layer B particle layer is composed of 80-85% low-pressure high-density polyethylene resin and 15-20% high-pressure low-density polyethylene resin. The third layer C particle layer is composed of 80-85% medium-density metallocene, 10-15% high-pressure low-density polyethylene resin, 0.5-2% opening agent, and 0.5-2% slip agent.

[0069] The processing steps for preparing the modified high moisture-barrier PE film layer 13 in step 1) of this invention include the following steps:

[0070] Step 11) Weigh each component according to the percentage of each particle layer in the modified high moisture barrier PE film layer 13 and mix them. Then add them to the three barrels of the extruder to obtain the mixture of the first A layer particle layer, the second B layer particle layer and the third C layer particle layer respectively.

[0071] Step 12) The mixture in the three barrels of Step 11) is melted at high temperature through the high temperature heating and melting device of the extruder to form a tube blank. The temperature required for high temperature melting is 180-300℃.

[0072] Step 13) After stretching the tube blank, it is extruded from the center of the extruder die and compressed with air, causing the tube blank to inflate into a film bubble. At the same time, the film bubble is cooled and shaped by the air ring to obtain a film.

[0073] Step 14) The film prepared in step 13) is fed into an aluminizing machine for double corona vacuum evaporation. The modified high moisture barrier PE film layer 13 is obtained after double corona vacuum evaporation treatment. The water vapor transmission rate of the modified high moisture barrier PE film layer 13 is 0.6~0.9 g / (m²). 2 (24h). Compared with ordinary linear low-density polyethylene, the modified high-moisture-barrier PE film layer 13 prepared by the present invention using a first A-layer particle layer, a second B-layer particle layer, and a third C-layer particle layer has a higher high-pressure low-density content and can achieve a higher crystallinity under stress, thereby obtaining a smaller free volume fraction and reducing the glass transition temperature T of the polymer molecules. g Increased water vapor permeability improves the barrier properties of the material; conventional PE films have a water vapor permeability of 2.0~4.0 g / (m²). 2 After 24 hours, the water vapor transmission rate of the modified high moisture-barrier PE was 0.6~0.9 g / (m²). 2•24h). In this invention, the composite sheet 1 is prepared by using a modified high moisture-barrier PE film layer 13 as a double corona layer, which greatly improves the barrier properties of the composite sheet 1.

[0074] The PE easy-peel film layer 25 in step 7) is prepared by co-extrusion of four layers: a corona layer, an intermediate layer, a bonding layer, and a heat-sealing layer. The corona layer accounts for 30%, the intermediate layer accounts for 30%, the bonding layer accounts for 20%, and the heat-sealing layer accounts for 20%. Specifically, the corona layer of the PE easy-peel film layer 25 is composed of 70-75% ethylene and 20%-30% propylene binary copolymer, the intermediate layer is made of 100% polypropylene, the bonding layer is made of 25-35% metallocene polypropylene, 20-30% metallocene polyethylene, and 30-40% butene terpolymer polypropylene, and the heat-sealing layer is made of 30-40% low-density polyethylene and 70-60% low-crystallinity α-olefin copolymer. The materials corresponding to each layer of the corona layer, intermediate layer, bonding layer, and heat-sealing layer are added to an extruder and heated and melted. After melting, each layer of material is co-extruded, blown and cooled, and drawn and shaped to obtain the PE easy-peel film layer 25. Compared with ordinary heat-sealing PE film, the PE easy-open film layer 25 prepared by this invention has moderate heat-sealing strength when used as a pallet cover film 2. Under the premise of ensuring the safety of the packaged goods during transportation, the opening force is moderate, and the tear is smooth and linear, which can bring consumers a good experience.

[0075] I. The present invention will be further described below with reference to specific embodiments provided by the present invention:

[0076] In a specific embodiment of the present invention, the composite sheet 1 of the present invention can be prepared and processed using the following film layers and their corresponding components. The specific film layer structures are shown in Table 1 below:

[0077]

[0078] Table 1

[0079] 2. In a specific embodiment three of the present invention, the tray cover film 2 of the present invention can be prepared and processed using the following film layers and their corresponding components. The specific film layer structures are shown in Table 2 below:

[0080]

[0081] Table 2

[0082] 3. In specific embodiment four of the present invention, the plastic flexible packaging tray of the present invention can be prepared by the following processing method, and the specific preparation process includes the following steps:

[0083] Step 1) Material selection and processing of composite sheet 1: A 300μm thick polyethylene terephthalate film layer 11 is selected as the surface layer for preparing composite sheet 1. A 60μm thick modified high moisture barrier PE film layer 13 is selected as the double corona layer for preparing composite sheet 1. A 60μm thick CPP film layer 15 is selected as the heat-sealing layer for preparing composite sheet 1. The modified high moisture barrier PE film layer 13 is prepared using the following processing steps:

[0084] Step 11) The modified high moisture barrier PE film layer 13 is prepared by the following weight percentage components: the first layer A particle layer is weighed as 100% linear medium density polyethylene resin, the first layer B particle layer is weighed as 85% low pressure high density polyethylene resin and 15% high pressure low density polyethylene resin, and the third layer C particle layer is weighed as 81% medium density metallocene, 15% high pressure low density polyethylene resin, 2% opening agent and 2% slip agent. The mixture is then added to the three barrels of the extruder to obtain the mixture of the first layer A particle layer, the mixture of the second layer B particle layer and the mixture of the third layer C particle layer.

[0085] Step 12) The mixture in the three barrels of Step 11) is melted at high temperature through the high temperature heating and melting device of the extruder to form a tube blank. The temperature required for high temperature melting is 180-300℃.

[0086] Step 13) After stretching the tube blank, it is extruded from the center of the extruder die and compressed with air, causing the tube blank to inflate into a film bubble. At the same time, the film bubble is cooled and shaped by the air ring to obtain a film.

[0087] Step 14) The film prepared in step 13) is fed into an aluminizing machine and subjected to double corona vacuum evaporation. After double corona vacuum evaporation treatment, a modified high moisture barrier PE film layer 13 is obtained.

[0088] Step 2) First dry lamination treatment of semi-finished composite sheet 103: The 60μm thick modified high moisture barrier PE film layer 13 selected in Step 1) is loaded onto the first feeding guide roller group 3 of the dry laminating machine. At the same time, the selected 300μm thick polyethylene terephthalate film layer 11 is loaded onto the second feeding guide roller group 4 of the dry laminating machine. The first feeding guide roller group 3 of the dry laminating machine feeds the 60μm thick modified high moisture barrier PE film layer 13 into the coating system. The modified high moisture barrier PE film layer 13 passes through the coating roller 6 and pressure roller 7 of the coating system. Under the action of the coating roller 6 and pressure roller 7, the first two-component polyurethane adhesive 12 is coated on the inner surface of the treated surface of the modified high moisture barrier PE film layer 13. Then the modified high moisture barrier PE film layer 13 is sent into the drying oven 31. After passing through the drying oven 31... Three drying tunnels heat the solvent of the first two-component polyurethane adhesive 12 on the modified high moisture barrier PE film layer 13 to evaporate it. The temperatures of the three drying tunnels are set to 60℃, 70℃ and 80℃ respectively. After drying, the modified high moisture barrier PE film layer 13 reaches the pressure roller 9 and hot steel roller 10 along the guide roller group 5. The 300μm thick polyethylene terephthalate film layer 11 is fed to the pressure roller 9 and hot steel roller 10 through the second feeding guide roller group 4 of the dry laminating machine. Under the hot pressing action of the pressure roller 9 and hot steel roller 10, the polyethylene terephthalate film layer 11 and the modified high moisture barrier PE film layer 13 coated with the first two-component polyurethane adhesive 12 are hot-pressed together to form a composite polyethylene terephthalate film layer 11 / modified high moisture barrier PE film layer 13 semi-finished composite sheet 103.

[0089] Step 3) Cooling treatment of semi-finished composite sheet 103: The semi-finished composite sheet 103 of polyethylene terephthalate film layer 11 / modified high moisture barrier PE film layer 13 obtained after step 2) is fed to cooling roller 101 along guide roller group 5 for room temperature cooling. The room temperature cooling time is not less than 12 hours. After cooling, the semi-finished composite sheet 103 of polyethylene terephthalate film layer 11 / modified high moisture barrier PE film layer 13 is wound up by winding guide roller 102.

[0090] Step 4) Second dry lamination treatment of composite sheet 1: The 60μm thick CPP film layer 15 selected in Step 1) is loaded onto the first feeding guide roller group 3 of the dry laminating machine. At the same time, the semi-finished composite sheet 103 of polyethylene terephthalate film layer 11 / modified high moisture barrier PE film layer 13 after cooling in Step 3) is loaded onto the second feeding guide roller group 4 of the dry laminating machine. The 60μm thick CPP film layer 15 is sent to the coating system through the first feeding guide roller group 3 of the dry laminating machine. The CPP film layer 15 passes through the coating roller 6 and pressure roller 7 of the coating system. Under the action of the coating roller 6 and pressure roller 7, the second two-component polyurethane adhesive 14 is coated on the inner surface of the treated surface of the CPP film layer 15. Then the CPP film layer 15 is sent into the drying oven 31. After passing through the three drying channels of the drying oven 31, the second two-component polyurethane adhesive on the CPP film layer 15 is coated. The solvent of polyurethane adhesive 14 is heated to evaporate. The temperatures of the three drying tunnels are set to 60°C, 70°C, and 80°C, respectively. After drying, the CPP film layer 15 reaches the pressure roller 9 and hot steel roller 10 along the guide roller group 5. At the same time, the second feeding guide roller group 4 of the dry laminating machine will send the semi-finished composite sheet 103 of polyethylene terephthalate film layer 11 / modified high moisture barrier PE film layer 13 to the pressure roller 9 and hot steel roller 10. Under the hot pressing action of the pressure roller 9 and hot steel roller 10, the semi-finished composite sheet 103 of polyethylene terephthalate film layer 11 / modified high moisture barrier PE film layer 13 and the CPP film layer 15 coated with the second two-component polyurethane adhesive 14 are hot-pressed together to form a composite sheet 1 of polyethylene terephthalate film layer 11 / modified high moisture barrier PE film layer 13 / CPP film layer 15.

[0091] Step 5) Cooling treatment of composite sheet 1: The composite sheet 1 obtained after step 4) of polyethylene terephthalate film layer 11 / modified high moisture barrier PE film layer 13 / CPP film layer 15 is fed to cooling roller 101 along guide roller group 5 for room temperature cooling. The room temperature cooling time is not less than 72 hours. After cooling, the composite sheet 1 of polyethylene terephthalate film layer 11 / modified high moisture barrier PE film layer 13 / CPP film layer 15 is wound up by winding guide roller 102.

[0092] Step 6) Slitting and packaging of composite sheet 1: The edges of the composite sheet 1 after curing in step 5) are cut off by a slitting machine, and the composite sheet 1 is slitting into blister composite sheets for pharmaceutical packaging, and then packaged.

[0093] Step 7) Material selection for the preparation of tray cover film 2: After the composite sheet 1 is packaged, a 40g single-sided coated paper layer 21 is selected as the printing layer of tray cover film 2, a 9μm thick AL foil layer 23 is selected as the intermediate barrier layer of tray cover film 2, and a 50μm thick PE easy-peel film layer 25 is selected as the inner heat-sealing layer of tray cover film 2. The PE easy-peel film layer 25 is prepared by configuring the components of each layer according to the following weight percentages. The corona layer of PE easy-peel film layer 25 is composed of 75% ethylene and 25% propylene binary copolymer, the intermediate layer is composed of 100% polypropylene, the bonding layer is composed of 30% metallocene polypropylene, 30% metallocene polyethylene, and 40% butene terpolymer polypropylene, and the heat-sealing layer is composed of 40% low-density polyethylene and 60% low-crystallinity α-olefin copolymer. The materials corresponding to each layer of corona layer, intermediate layer, bonding layer and heat-sealing layer are added to an extruder and heated and melted. After melting, each layer of material is co-extruded, blown and cooled, and drawn and shaped to obtain PE easy-peel film layer 25.

[0094] Step 8) First dry lamination treatment of semi-finished pallet cover film 35: The 9μm thick AL foil layer 23 selected in step 7) is loaded onto the first unwinding guide roller group 26 of the laminating machine, and the selected 40g single-sided coated paper layer 21 is loaded onto the second unwinding guide roller group 27 of the laminating machine. The 9μm thick AL foil layer 23 is fed into the gluing system through the first unwinding guide roller group 26 of the laminating machine. The AL foil layer 23 passes through the coating roller 29 and the pressure roller 30 of the gluing system. Under the action of the coating roller 29 and the pressure roller 30, the first coat of two-component polyurethane adhesive 22 is applied to the inner surface of the treated surface of the AL foil layer 23. Then the AL foil layer 23 is sent into the drying oven 31 and undergoes three drying passes in the drying oven 31 to dry the AL foil layer 23. The solvent of the first two-component polyurethane adhesive 22 is heated to evaporate. The temperatures of the three drying tunnels are set to 50℃, 60℃, and 70℃, respectively. After drying, the AL foil layer 23 is pulled along the guide roller 28 to the pressing guide roller 32 and the hot steel guide roller 33. At the same time, the second unwinding guide roller group 27 of the laminating machine feeds 40g of single-sided coated paper layer 21 to the pressing guide roller 32 and the hot steel guide roller 33. Under the hot pressing action of the pressing guide roller 32 and the hot steel guide roller 33, the single-sided coated paper layer 21 and the AL foil layer 23 coated with the first two-component polyurethane adhesive 22 are hot-pressed together to form a composite single-sided coated paper layer 21 / AL foil layer 23 semi-finished tray cover film 35, which is then wound up by the winding roller 34.

[0095] Step 9) Curing treatment of semi-finished pallet cover film 35: The semi-finished pallet cover film 35 with single-sided coated paper layer 21 / AL foil layer 23 obtained after step 8) is sent into the curing chamber for curing. The curing temperature is 45℃ and the curing time is 36h.

[0096] Step 10) Second dry lamination treatment of tray cover film 2: The semi-finished tray cover film 35 with single-sided coated paper layer 21 / AL foil layer 23 after curing in step 9) is loaded onto the first unwinding guide roller group 26 of the laminating machine. The 50μm thick PE easy-peel film layer 25 selected in step 7) is loaded onto the second unwinding guide roller group 27 of the laminating machine. The first unwinding guide roller group 26 of the laminating machine loads the semi-finished tray cover film 35 with single-sided coated paper layer 21 / AL foil layer 23. The semi-finished pallet cover film 35, with a single-sided paper layer 21 and an AL foil layer 23, is fed into the gluing system. It passes through the gluing roller 29 and the pressure roller 30. Under the action of the gluing roller 29 and the pressure roller 30, a second layer of two-component polyurethane adhesive 24 is applied to the single-sided coated paper layer 21 / AL foil layer 23 semi-finished pallet cover film 35. Then, the single-sided coated paper layer 21 / AL foil layer 23 semi-finished pallet cover film 35 is sent into the drying oven 31 for drying. The three drying tunnels of box 31 heat the solvent of the second two-component polyurethane adhesive 24 on the semi-finished tray cover film 35 of the single-sided coated paper layer 21 / AL foil layer 23 to evaporate it. The temperatures of the three drying tunnels are set to 50℃, 60℃, and 70℃ respectively. After drying, the semi-finished tray cover film 35 of the single-sided coated paper layer 21 / AL foil layer 23 is drawn along the guide roller 28 to the pressure roller 9 and the hot steel roller 10. At the same time, the second unwinding guide roller group 2 of the laminating machine... 7. The PE easy-peel film layer 25 is fed to the pressing guide roller 32 and the hot steel guide roller 33. Under the hot pressing action of the pressing guide roller 32 and the hot steel guide roller 33, the PE easy-peel film layer 25 and the semi-finished pallet cover film 35 with a single-sided coated paper layer 21 / AL foil layer 23 coated with a second layer of two-component polyurethane adhesive 24 are hot-pressed and bonded together to form a composite pallet cover film 2 with a single-sided coated paper layer 21 / AL foil layer 23 / PE easy-peel film layer 25, which is then wound up by the winding roller 34.

[0097] Step 11) Curing treatment of tray cover film 2: The tray cover film 2 with single-sided coated paper layer 21 / AL foil layer 23 / PE easy-peel film layer 25 obtained after step 8) is sent into the curing chamber for curing. The curing temperature is 45℃ and the curing time is 36h.

[0098] Step 12) Cooling treatment of tray cover film 2: The tray cover film 2 with single-sided coated paper layer 21 / AL foil layer 23 / PE easy-peel film layer 25 obtained after curing in step 11) is cooled at room temperature for 24 hours.

[0099] Step 13) Slitting of composite sheet 1: Slit the cooled tray cover film 2 from step 12) into tray cover films 2 that match the size of composite sheet 1, and pack them into the warehouse;

[0100] Step 14) Prepare a plastic flexible packaging tray: According to the required shape of the medicine packaging, the composite sheet 1 is vacuum-formed into a composite sheet box 100, then the medicine is filled into the composite sheet box 100, and then the tray cover film 2 is attached to the edge of the composite sheet box 100 by an automatic packaging machine to form a sealed plastic flexible packaging tray.

[0101] II. The plastic flexible packaging tray prepared using Example 4 above was tested for its ease of opening and barrier properties. The specific test results are as follows:

[0102] (i) Test on the opening force of the tray cover film 2 after heat sealing with the box sheet (easy-open test)

[0103] 1. Test subject:

[0104] (a) Select 10 composite sheet boxes 100 prepared using the processing method of Example 4 and 10 tray cover films 2 that match the size planning of the composite sheet box 100. Place the specified oral liquid medicine in each of the 10 composite sheet boxes 100. Then, use an automatic packaging machine to attach each tray cover film 2 to the edge of the composite sheet box 100 to form a sealed plastic soft packaging tray sample. Each plastic soft packaging tray sample is used as a test point for the experiment. There are a total of 10 test points. The 10 test points are numbered as follows: Tray cover film 2 test point T1, Tray cover film 2 test point T2, Tray cover film 2 test point T3, Tray cover film 2 test point T4, Tray cover film 2 test point T5, Tray cover film 2 test point T6, Tray cover film 2 test point T7, Tray cover film 2 test point T8, Tray cover film 2 test point T9, and Tray cover film 2 test point T10.

[0105] (b) Select 10 composite sheet boxes 100 prepared using the processing method of Example 4, and place the specified oral liquid medicine in each of the 10 composite sheet box boxes 100. Then select 10 traditional cap films (single-layer PE film), and use an automatic packaging machine to seal the 10 composite sheet box boxes 100 containing the oral liquid medicine with the 10 traditional cap films. Each box sealed with a traditional cap film is used as a test point for the experiment, for a total of 10 test points. The 10 test points are numbered as follows: Traditional cap film test point T1, Traditional cap film test point T2, Traditional cap film test point T3, Traditional cap film test point T4, Traditional cap film test point T5, Traditional cap film test point T6, Traditional cap film test point T7, Traditional cap film test point T8, Traditional cap film test point T9, and Traditional cap film test point T10.

[0106] 2. Test method: According to "QB T 2358-1998 Test method for heat seal strength of plastic film packaging bags", the heat seal strength between the pallet cover film 2 and the box sheet and the heat seal strength between the traditional cover film and the box sheet were tested using a "Shimadzu AGS-X" tensile testing machine.

[0107] 3. The test results are shown in Table 3 below:

[0108]

[0109] Table 3

[0110] Conclusion: The test results are shown in Table 3 above. Analysis of the test data shows that the average opening force between the traditional lid film and the composite sheet box 100 is approximately 64.7 N. While this meets the requirements for packaging and transportation safety, the opening force is relatively large, making it difficult to open. In contrast, the average opening force between the tray lid film 2 and the composite sheet box 100 prepared using the processing method of this invention is 30.4 N, which is moderate. This moderate opening force satisfies both packaging safety and the sealing safety of oral liquid medicines. Furthermore, the opening force of 30 N is also suitable, allowing even a child to easily open and consume the contents, making it convenient for consumers. Therefore, the plastic flexible packaging tray sealed with the tray lid film 2 prepared using the method of this invention has a better ease-to-open effect.

[0111] (ii) Barrier test on composite sheet box 100

[0112] 1. Test subject:

[0113] (a) Five composite sheet boxes 100 prepared using the processing method of Example 4 and five tray cover films 2 that match the size planning of the composite sheet box 100 were selected. The specified oral liquid medicine was placed in each of the five composite sheet boxes 100. Each tray cover film 2 was attached to the edge of the composite sheet box 100 by an automatic packaging machine to form a sealed plastic soft packaging tray sample. Each plastic soft packaging tray sample was used as a test sample for testing. There were a total of five test samples. The five test samples were numbered as composite sheet box 100 test sample T1, composite sheet box 100 test sample T2, composite sheet box 100 test sample T3, composite sheet box 100 test sample T4, and composite sheet box 100 test sample T5.

[0114] (b) Select five ordinary boxes made of PET single-layer sheet material, and place the specified oral liquid medicine in each of the five ordinary boxes. Then select five tray cover films 2 prepared by the processing method of Example 4, and seal the remaining five ordinary boxes containing oral liquid medicine with these five tray cover films 2. Each ordinary box will be used as a test sample for testing. There are a total of five test samples. The five test samples are numbered as ordinary box test sample T1, ordinary box test sample T2, ordinary box test sample T3, ordinary box test sample T4, and ordinary box test sample T5.

[0115] 2. Test Methods: Following GB / T 26253-2010 "Determination of Water Vapor Transmission Rate of Plastic Films and Sheets - Infrared Detector Method", a "Memcon MODEL 3 / 61 Water Vapor Transmission Rate Tester" was used to conduct barrier tests on five composite sheet box 100 test samples T1, T2, T3, T4, and T5. Similarly, following GB / T 26253-2010 "Determination of Water Vapor Transmission Rate of Plastic Films and Sheets - Infrared Detector Method", a "Memcon MODEL 3 / 61 Water Vapor Transmission Rate Tester" was used to conduct barrier tests on five ordinary box test samples T1, T2, T3, T4, and T5.

[0116] 3. The test results are shown in Table 4 below:

[0117]

[0118] Table 4

[0119] 4. Test Conclusion: As shown in Table 4 above, the average water vapor transmission rate of the composite sheet box 100 prepared using the processing method of this invention is 0.9 g / (m²). 2 •24h), while the average water vapor transmission rate of ordinary boxes made of single-layer PET material is 2.5g / (m²). 2 (24h) Compared with ordinary boxes, the composite sheet box 100 used in this invention has a significant barrier effect.

[0120] (III) Barrier test on composite sheet box 100

[0121] 1. Test subject:

[0122] (a) Five composite sheet boxes 100 prepared using the processing method of Example 4 and five tray cover films 2 that match the size planning of the composite sheet boxes 100 were selected. Oral liquid medicines weighing 97.03g, 97.21g, 97.15g, 97.09g, and 97.39g were placed in the five composite sheet boxes 100 respectively. Each tray cover film 2 was attached to the edge of the composite sheet box 100 by an automatic packaging machine to form a sealed plastic soft packaging tray sample. Each plastic soft packaging tray was used as a sample for the experiment. There were a total of 5 test samples, and the test samples were numbered as plastic soft packaging tray T1, plastic soft packaging tray T2, plastic soft packaging tray T3, plastic soft packaging tray T4, and plastic soft packaging tray T5.

[0123] (b) Five ordinary boxes made of PET single-layer sheet were selected, and oral liquid medicine weighing 85.22 g, 85.26 g, 85.31 g, 85.20 g and 85.24 g respectively were placed in the five ordinary boxes. Five tray cover films 2 prepared by the processing method of Example 4 were selected, and the remaining five ordinary boxes containing oral liquid medicine were sealed with the five tray cover films 2. Each ordinary box was used as a sample for the experiment, and a total of five test samples were made. The test samples were numbered as ordinary box B1, ordinary box B2, ordinary box B3, ordinary box B4 and ordinary box B5.

[0124] 2. Test method: Ten test samples, namely plastic flexible packaging tray T1, plastic flexible packaging tray T2, plastic flexible packaging tray T3, plastic flexible packaging tray T4, plastic flexible packaging tray T5 and ordinary box B1, ordinary box B2, ordinary box B3, ordinary box B4, and ordinary box B5, were placed in a constant temperature and humidity chamber with a relative humidity of 30% and a temperature of 40℃. The weight of the ten test samples was measured on days 0, 7, 13, 20, 27, 34, 41, 48, 55, and 62.

[0125] 3. The test results are shown in Table 5 below:

[0126]

[0127] Table 5

[0128] 4. Test Conclusion: As shown in Table 5 above, using commercially available ordinary boxes to package oral liquid medicines, which are made of single-layer PET material through thermoforming, results in limited barrier properties, leading to weight loss (i.e., a decrease in gram weight) of the oral liquid medicine during long-term storage. However, the composite sheet box 100 obtained by combining the modified high-moisture-barrier PE film layer 13, polyethylene terephthalate film layer 11, and CPP film layer 15 using the preparation method of this invention significantly improves the barrier properties of the composite sheet box 100. The water vapor permeability of the composite sheet box 100 is measured. When using the tray cover film 2 and the composite sheet box 100 prepared by this invention to package oral liquid medicines, the average weight loss after two months is 0.58g, with a weight loss ratio of 0.6%. In contrast, when using ordinary boxes on the market to package oral liquid medicines, the average weight loss after two months is 1.05g, with a weight loss ratio of 1.2%. Compared with ordinary boxes, the composite sheet box 100 used in this invention has a significant barrier effect, which can prevent serious weight loss problems of oral liquid medicines.

[0129] Based on the above embodiments and test results, it can be seen that the processing method of the present invention can modify the high moisture-resistant PE film layer 13, polyethylene terephthalate film layer 11, and CPP film layer 15 to obtain a composite sheet box 100, and hot-press the single-sided coated paper layer 21, AL foil layer 23, and PE easy-peel film layer 25 to form a composite tray cover film 2. The composite sheet obtained by using multiple film layers has good stability and can avoid deformation, breakage or delamination under external force. It is suitable for pharmaceutical packaging and can significantly extend the shelf life of pharmaceuticals. It can also use an automatic packaging machine to attach the tray cover film 2 to the edge of the composite sheet box 100 to form a sealed plastic soft packaging tray. The resulting plastic soft packaging tray has high barrier and easy-to-open characteristics. The heat seal strength between the composite sheet box 100 and the tray cover film 2 on the top is moderate. The tray cover film 2 can be opened without the need for tools, which is convenient for consumers to consume oral liquid medicines and can bring consumers a good experience.

[0130] The present invention has been described in detail above. The above description is only a preferred embodiment of the present invention and should not be construed as limiting the scope of this application. All equivalent changes and modifications made in accordance with the scope of this application should still fall within the scope of the present invention.

Claims

1. A process for the production of plastic flexible packaging trays for pharmaceutical packaging, characterized in that: The application relates to a processing method for processing and preparing a plastic soft package tray, and the plastic soft package tray is prepared by processing a composite sheet box body and a tray cover film, and the processing method comprises the following processing steps: Step 1: material selection and processing of the composite sheet: a 300-micron-thick polyethylene terephthalate film layer is selected as a surface layer of the composite sheet, a prepared 60-micron-thick modified high-moisture-resistance PE film layer is selected as a double corona layer of the composite sheet, and a 60-micron-thick CPP film layer is selected as a heat sealing layer of the composite sheet, the modified high-moisture-resistance PE film layer is made of a first layer A particle layer, a second layer B particle layer and a third layer C particle layer, the first layer A particle layer accounts for 30%, the first layer B particle layer accounts for 40%, and the third layer C particle layer accounts for 30%; the first layer A particle layer is composed of 100% linear medium-density polyethylene resin; the first layer B particle layer is composed of 80-85% low-pressure high-density polyethylene resin and 15-20% high-pressure low-density polyethylene resin; and the third layer C particle layer is composed of 80-85% medium-density metallocene, 10-15% high-pressure low-density polyethylene resin, 0.5-2% opening agent and 0.5-2% slip agent; Step 2: first dry composite processing of the semi-finished composite sheet: the prepared 60-micron-thick modified high-moisture-resistance PE film layer selected in step 1 is loaded on a first feeding guide roller group of a dry composite machine, meanwhile, the selected 300-micron-thick polyethylene terephthalate film layer is loaded on a second feeding guide roller group of the dry composite machine, the 60-micron-thick modified high-moisture-resistance PE film layer is sent to a gluing system by the first feeding guide roller group, the modified high-moisture-resistance PE film layer passes through gluing rollers and pressure rollers of the gluing system, the first double-component polyurethane adhesive is coated on the processing inner face of the modified high-moisture-resistance PE film layer under the action of the gluing rollers and the pressure rollers, the modified high-moisture-resistance PE film layer is sent to a drying oven, solvents of the first double-component polyurethane adhesive on the modified high-moisture-resistance PE film layer are heated to volatilize by three drying channels of the drying oven, the temperatures of the three drying channels are respectively set as 60 DEG C, 70 DEG C and 80 DEG C, the modified high-moisture-resistance PE film layer after drying reaches pressure rollers and hot steel rollers along guide roller groups, the 300-micron-thick polyethylene terephthalate film layer is sent to the pressure rollers and the hot steel rollers by the second feeding guide roller group, and the polyethylene terephthalate film layer is hot-pressed and combined with the modified high-moisture-resistance PE film layer coated with the first double-component polyurethane adhesive to form a semi-finished composite sheet of the polyethylene terephthalate film layer / modified high-moisture-resistance PE film layer after composite. Step 3) Cooling treatment of the semi-finished composite sheet: the semi-finished PETG film layer / modified high-wet-resistance PE film layer composite sheet obtained after step 2) is sent to a cooling roller along a guide roller group for normal temperature cooling, the time for normal temperature cooling is not less than 12 hours, and the cooled semi-finished PETG film layer / modified high-wet-resistance PE film layer composite sheet is wound through a winding guide roller; Step 4) Second dry lamination treatment of the composite sheet: the 60μm-thick CPP film layer selected in step 1) is loaded on a first feeding guide roller group of a dry lamination machine, and the semi-finished PETG film layer / modified high-wet-resistance PE film layer composite sheet cooled in step 3) is loaded on a second feeding guide roller group of the dry lamination machine, the 60μm-thick CPP film layer is sent to a glue coating system through the first feeding guide roller group of the dry lamination machine, the CPP film layer passes through glue coating rollers and pressure rollers of the glue coating system, and the second two-component polyurethane adhesive is coated on the inner surface of the CPP film layer under the action of the glue coating rollers and the pressure rollers, and then the CPP film layer is sent into a drying oven, the solvent of the second two-component polyurethane adhesive on the CPP film layer is volatilized by heating through three drying channels of the drying oven, the temperatures of the three drying channels are set to 60℃, 70℃ and 80℃ respectively, and then the dried CPP film layer reaches a compression roller and a hot steel roller along a guide roller group, meanwhile, the second feeding guide roller group of the dry lamination machine sends the semi-finished PETG film layer / modified high-wet-resistance PE film layer composite sheet to the compression roller and the hot steel roller, and the semi-finished PETG film layer / modified high-wet-resistance PE film layer composite sheet is hot-pressed with the CPP film layer coated with the second two-component polyurethane adhesive to form a composite PETG film layer / modified high-wet-resistance PE film layer / CPP film layer composite sheet; Step 5) Cooling treatment of the composite sheet: the composite PETG film layer / modified high-wet-resistance PE film layer / CPP film layer composite sheet obtained after step 4) is sent to a cooling roller along a guide roller group for normal temperature cooling, the time for normal temperature cooling is not less than 72 hours, and the cooled composite PETG film layer / modified high-wet-resistance PE film layer / CPP film layer composite sheet is wound through a winding guide roller; Step 6) Slitting and packaging treatment of the composite sheet: the edges of the composite sheet after step 5) are cut off through a slitting machine, the composite sheet is slitted into blister composite sheets for medicine packaging, and the blister composite sheets are packaged; Step 7) Preparation and selection of the tray cover film: after the composite sheet is packaged, a 40g single-side coated paper layer is selected as a printing layer of the tray cover film, a 9μm-thick AL foil layer is selected as a middle barrier layer of the tray cover film, and a prepared 50μm-thick PE easy-to-peel film layer is selected as an inner heat-sealing layer of the tray cover film. Step 8) First dry composite processing of the semi-finished tray cover film: the 9μm thick AL foil layer selected in step 7 is loaded on the first unwinding guide roller group of the laminator, and the 40g single-sided coated paper layer selected is loaded on the second unwinding guide roller group of the laminator. The 9μm thick AL foil layer is sent to the glue applying system through the first unwinding guide roller group of the laminator. The AL foil layer passes through the coating and pressing rollers of the glue applying system. Under the action of the coating and pressing rollers, the first double-component polyurethane adhesive is coated on the inner surface of the processing surface of the AL foil layer. Then the AL foil layer is sent to the oven. The solvent of the first double-component polyurethane adhesive on the AL foil layer is heated to evaporate through the three heating channels of the oven. The temperatures of the three heating channels are set to 50℃, 60℃ and 70℃ respectively. After drying, the AL foil layer is pulled along the guide roller to the pressing and hot steel rollers. At the same time, the second unwinding guide roller group of the laminator sends the 40g single-sided coated paper layer to the pressing and hot steel rollers. Under the hot pressing action of the pressing and hot steel rollers, the single-sided coated paper layer is hot-pressed and combined with the AL foil layer coated with the first double-component polyurethane adhesive to form a semi-finished single-sided coated paper layer / AL foil layer tray cover film, which is wound by the winding roller; Step 9) Curing process of the semi-finished tray cover film: the semi-finished single-sided coated paper layer / AL foil layer tray cover film obtained after the composite process in step 8 is sent into the curing room for curing. The curing temperature is 45℃ and the curing time is 36h; Step 10) Second dry composite processing of the tray cover film: the semi-finished single-sided coated paper layer / AL foil layer tray cover film after curing in step 9 is loaded on the first unwinding guide roller group of the laminator, and the 50μm thick PE easy-to-peel film layer selected in step 7 is loaded on the second unwinding guide roller group of the laminator. The semi-finished single-sided coated paper layer / AL foil layer tray cover film is sent to the glue applying system through the first unwinding guide roller group of the laminator. The semi-finished single-sided coated paper layer / AL foil layer tray cover film passes through the coating and pressing rollers of the glue applying system. Under the action of the coating and pressing rollers, the second double-component polyurethane adhesive is coated on the semi-finished single-sided coated paper layer / AL foil layer tray cover film. Then the semi-finished single-sided coated paper layer / AL foil layer tray cover film is sent to the oven. The solvent of the second double-component polyurethane adhesive on the semi-finished single-sided coated paper layer / AL foil layer tray cover film is heated to evaporate through the three heating channels of the oven. The temperatures of the three heating channels are set to 50℃, 60℃ and 70℃ respectively. After drying, the semi-finished single-sided coated paper layer / AL foil layer tray cover film is pulled along the guide roller to the pressing and hot steel rollers. At the same time, the second unwinding guide roller group of the laminator sends the PE easy-to-peel film layer to the pressing and hot steel rollers. Under the hot pressing action of the pressing and hot steel rollers, the PE easy-to-peel film layer is hot-pressed and combined with the semi-finished single-sided coated paper layer / AL foil layer tray cover film coated with the second double-component polyurethane adhesive to form a semi-finished single-sided coated paper layer / AL foil layer / PE easy-to-peel film layer tray cover film, which is wound by the winding roller; Step 11) curing treatment of tray cover film: the tray cover film obtained after step 8) of single-side coated paper layer / AL foil layer / PE easy-to-peel film layer after compounding is sent into a curing chamber for curing, the curing temperature is 45℃, and the curing time is 36h; Step 12) cooling treatment of tray cover film: the tray cover film obtained after step 11) of single-side coated paper layer / AL foil layer / PE easy-to-peel film layer after curing is cooled at room temperature, and the cooling time is 24h; Step 13) slitting of composite sheet: the tray cover film after cooling in step 12) is slitted into tray cover film with a size matching that of the composite sheet, and is packed for storage; Step 14) preparation of plastic soft-packaging tray: the composite sheet is sucked into a composite sheet box according to the shape required by the packaging of the medicine, then the medicine is filled into the composite sheet box, and the automatic packaging machine is used to attach the tray cover film to the edge of the composite sheet box to form a sealed plastic soft-packaging tray; The first and second two-component polyurethane adhesives used in steps 2) and 4) are two-component polyurethane adhesives of model "XH-66F / XH-K75". The raw material composition and ratio of the two-component polyurethane adhesives are main agent XH-66F: curing agent XH-K75: ethyl acetate solvent = 20:3.0:30.

9. The working liquid concentration of the two-component polyurethane adhesives is 25-32%. The viscosity of the two-component polyurethane adhesives is 15±2 pascal seconds. The viscosity of the two-component polyurethane adhesives is measured at a working liquid concentration (25-32%) of 25°C using a 3# Zahn cup. The gluing roller used in steps 2) and 4) has a gluing mesh of 140*55 concave mesh, and the gluing amount is 2.2 g / m 2 ; The first and second two-component polyurethane adhesives used in steps 8) and 10) are of the type "XH-66F / XH-K75", the raw material composition and ratio of which are main agent XH-66F: curing agent XH-K75: ethyl acetate solvent = 20:3.8:26, the working liquid concentration of the two-component polyurethane adhesive is 25-32%, and the viscosity of the two-component polyurethane adhesive is 15±2 pascal seconds, wherein the viscosity of the two-component polyurethane adhesive is measured by using a 3# Zahn cup at a working liquid concentration (25-32%) of 25°C. The coating and gluing roller used in steps 8) and 10) has a gluing mesh of 110*70 concave screen mesh, and the gluing amount is 3.2 g / m 2 .

2. The method of claim 1, wherein: Step 2) the tension required for the first unwinding guide roller group of the dry compounding machine to unwind the modified high-wet-resistance PE film layer is 5kgf, and the tension required for the second unwinding guide roller group of the dry compounding machine to unwind the polyethylene terephthalate film layer is 23kgf; Step 4) the tension required for the first unwinding guide roller group of the dry compounding machine to unwind the CPP film layer is 4kgf, and the tension required for the second unwinding guide roller group of the dry compounding machine to unwind the polyethylene terephthalate film layer / modified high-wet-resistance PE film layer semi-finished composite sheet is 25kgf, the speed of the hot-pressing compounding of the compression roller and the hot steel roller used in steps 2) and 4) is 60M / min, and the winding tension of the winding guide roller in steps 3) and 5) is 25kgf.

3. The method of claim 1, wherein: Step 8) the tension required for the first unwinding guide roller group of the compounding machine to unwind the AL foil layer is 12kgf, the tension required for the second unwinding guide roller group of the compounding machine to unwind the single-side coated paper layer is 20kgf, the tension required for the first unwinding guide roller group of the compounding machine to unwind the single-side coated paper layer / AL foil layer semi-finished tray cover film in step 10) is 20kgf, the tension required for the second unwinding guide roller group of the compounding machine to unwind the PE easy-to-peel film layer is 4gf, the speed of the hot-pressing compounding of the compression guide roller and the hot steel guide roller used in steps 8) and 10) is 90M / min, and the winding tension of the winding roller in steps 8) and 10) is 28kgf.

4. The method of claim 1, wherein: Step 1) the preparation of the modified high-wet-resistance PE film layer includes the following steps: Step 11) the components are weighed and mixed according to the percentage corresponding to each particle layer in the modified high-wet-resistance PE film layer, and then are respectively added into the three barrels of the extruder to respectively prepare the mixed material of the first layer A particle layer, the mixed material of the second layer B particle layer, and the mixed material of the third layer C particle layer; Step 12) the mixed materials in the three barrels in step 11) are subjected to high-temperature melting by the high-temperature melting device of the extruder to form a pipe blank, and the temperature required for high-temperature melting is 180-300℃; Step 13) After the pipe blank is stretched, it is extruded from the center of the extruder die and compressed air is blown into the pipe blank to form a film bubble, and the film bubble is cooled and shaped by the air ring to obtain the film; Step 14) The film prepared in step 13) is sent into an aluminizing machine, and the film is subjected to double corona vacuum evaporation, and a modified high moisture-resistant PE film layer is obtained through the double corona vacuum evaporation treatment. The water vapor transmission rate of the modified high moisture-resistant PE film layer obtained after preparation is 0.6~0.9g / (m 2 ·24h).

5. The method of claim 1, wherein: The PE easy-to-peel film layer is prepared by four-layer co-extrusion of a corona layer, an intermediate layer, a bonding layer and a heat-sealing layer, the corona layer accounts for 30%, the intermediate layer accounts for 30%, the bonding layer accounts for 20%, and the heat-sealing layer accounts for 20%.

6. The method of claim 5, wherein the method further comprises: The PE easy-to-peel film layer is prepared by four-layer co-extrusion of a corona layer, an intermediate layer, a bonding layer and a heat-sealing layer, the corona layer accounts for 30%, the intermediate layer accounts for 30%, the bonding layer accounts for 20%, and the heat-sealing layer accounts for 20%. The PE easy-to-peel film layer is prepared by four-layer co-extrusion of a corona layer, an intermediate layer, a bonding layer and a heat-sealing layer, the corona layer accounts for 30%, the intermediate layer accounts for 30%, the bonding layer accounts for 20%, and the heat-sealing layer accounts for 20%.

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