Steviol glycoside compositions with improved flavor profiles

Abstract

The present invention belongs to the technical field of sweeteners, and specifically relates to a steviol glycoside composition with improved flavor profile. The composition comprises two groups of SG, the first group of SG comprises one or more SG, and the SG has a parent structure of formula II or formula III; wherein R1 and R2 are substituents selected from glucosyl (G), rhamnosyl (R), xylosyl (X), deoxyglucosyl (dG), fructosyl (F), arabinosyl (A), galactosyl (Ga) or any combination of the above groups, and wherein the number of glucosyl groups is equal to or greater than 4; the second group of SG comprises one or more SGs selected from RA, RB, steviol glycoside, RC, RD, RM or a combination thereof; wherein the content of the first group of SG in the total SG is 1-30wt%. The composition has improved taste profile and solubility in aqueous solution, so as to facilitate use in the food and beverage industry.

Description

[0001] This application is a divisional application of the invention patent application entitled “Steviol glycoside composition with improved flavor”, which entered into China with application number 201980030382.3 and international application date PCT / US2019 / 031183 on May 7, 2019.

[0002] This application claims priority to the following U.S. provisional applications: 62 / 668,535 filed on May 8, 2018, 62 / 691,723 filed on June 29, 2018, and 62 / 730,449 filed on September 12, 2018. The above provisional applications are incorporated herein by reference. Technical Field

[0003] Generally speaking, the present invention is directed to a SG composition having a desired solubility and taste profile. Background Art

[0004] Steviol glycosides (SG) are high-intensity sweeteners that are widely used as sweeteners in food and beverage products. Many SGs have been isolated and identified, including rebaudioside A (RA), rebaudioside B (RB), stevioside (ST), steviol disaccharide (STB), rebaudioside C (RC), rebaudioside D (RD), etc.

[0005] Steviosides generally have poor solubility. The taste of some steviol glycosides, such as RA, also needs to be improved. Therefore, there is a need for steviol glycoside compositions with improved solubility and a desired taste profile in the food and beverage industry.

[0006] Therefore, there is a need for SG or steviol glycoside compositions with better solubility in the food and beverage industry. Summary of the invention

[0007] The first aspect of the present application relates to a composition containing SG from Table A, wherein the composition contains one or more SG with a molecular weight greater than 965 Daltons. In some embodiments, the content of SG with a molecular weight greater than 965 Daltons in the composition is greater than 0.2%. In some further embodiments, the content of SG with a molecular weight greater than 965 Daltons in the composition is greater than 0.5%. In some further embodiments, the content of SG with a molecular weight greater than 965 Daltons in the composition is greater than 1%.

[0008] In some embodiments, the composition comprises 15-35 wt% RA of the total SG. In other embodiments, the composition comprises 20-30 wt% RA of the total SG of the composition.

[0009] In some embodiments, the composition further comprises ST. In further embodiments, ST accounts for 15-30 wt% of the total SG in the composition.

[0010] In some embodiments, one or more SGs with a molecular weight greater than 965 Daltons are selected from related SG#2, related SG#5, RU2, RT, RW, RW2, RW3, RU, SG-12, RH, RJ, RK, RK2, SG-Ukn4, SG-Ukn5, RD, RI, RL, RI3, SG-Ukn6, RQ, RI2, RQ2, RQ3, RT1, related SG#4, RV2, RV, RY, RN, RM, 15α-OH RM, RO, and RO2.

[0011] In some embodiments, the composition comprises one or more SGs having a molecular weight equal to or greater than 981 Daltons. In some embodiments, the composition comprises one or more SGs having a molecular weight equal to or greater than 1097 Daltons. In some embodiments, the composition comprises one or more SGs having a molecular weight equal to or greater than 1111 Daltons. In some embodiments, the composition comprises one or more SGs having a molecular weight equal to or greater than 1127 Daltons. In some embodiments, the composition comprises one or more SGs having a molecular weight equal to or greater than 1259 Daltons. In some embodiments, the composition comprises one or more SGs having a molecular weight equal to or greater than 1273 Daltons. In some embodiments, the composition comprises one or more SGs having a molecular weight equal to or greater than 1289 Daltons. In some embodiments, the composition comprises one or more SGs having a molecular weight equal to or greater than 1305 Daltons. In some embodiments, the composition comprises one or more SGs having a molecular weight equal to or greater than 1435 Daltons.

[0012] In some embodiments, the composition further comprises RM. In some embodiments, RM is greater than 0.1wt% in the total SG of the composition. In some embodiments, RM is greater than 0.2wt% in the total SG of the composition. In some embodiments, RM is greater than 0.3wt% in the total SG of the composition. In some embodiments, RM is greater than 0.4wt% in the total SG of the composition. In some embodiments, RM is greater than 0.5wt% in the total SG of the composition. In some embodiments, RM is greater than 1wt% in the total SG of the composition. In some embodiments, RM is greater than 2wt% in the total SG of the composition. In some embodiments, RM is greater than 3wt% in the total SG of the composition. In some embodiments, RM is greater than 4wt% in the total SG of the composition. In some embodiments, RM is greater than 5wt% in the total SG of the composition. In some embodiments, RM is greater than 6wt% in the total SG of the composition. In some embodiments, RM is greater than 7wt% in the total SG of the composition. In some embodiments, RM is greater than 8wt% in the total SG of the composition. In some embodiments, RM is greater than 9wt% in the total SG of the composition. In some embodiments, RM is 0.5-10wt% in the total SG of the composition.

[0013] In some embodiments, the composition further comprises RN. In some embodiments, RN is greater than 0.1 wt% of the total SG of the composition. In some embodiments, RN is 0.1-2 wt% of the total SG of the composition.

[0014] In some embodiments, the composition further comprises RO. In some embodiments, RO is greater than 0.1 wt% of the total SG of the composition. In some embodiments, RO is greater than 0.2 wt% of the total SG of the composition. In some embodiments, RO is greater than 0.5 wt% of the total SG of the composition. In some embodiments, RO is greater than 1 wt% of the total SG of the composition. In some embodiments, RO is 0.2-1.5 wt% of the total SG of the composition.

[0015] In some embodiments, the composition further comprises RH. In some embodiments, RH is greater than 0 wt% of the total SG of the composition. In some embodiments, RH is greater than 0.1 wt% of the total SG of the composition. In some embodiments, RH is greater than 0.2 wt% of the total SG of the composition. In some embodiments, RH is 0-0.3 wt% of the total SG of the composition.

[0016] In some embodiments, the composition further comprises RI. In some embodiments, RI is greater than 0.1 wt% of the total SG of the composition. In some embodiments, RI is greater than 0.2 wt% of the total SG of the composition. In some embodiments, RI is greater than 0.3 wt% of the total SG of the composition. In some embodiments, RI is greater than 0.4 wt% of the total SG of the composition. In some embodiments, RI is 0.2-0.5 wt% of the total SG of the composition.

[0017] In some embodiments, the composition further comprises RI3. In some embodiments, RI3 is greater than 0.1wt% in the total SG of the composition. In some embodiments, RI3 is greater than 0.2wt% in the total SG of the composition. In some embodiments, RI3 is greater than 0.3wt% in the total SG of the composition. In some embodiments, RI3 is greater than 0.4wt% in the total SG of the composition. In some embodiments, RI3 is greater than 0.5wt% in the total SG of the composition. In some embodiments, RI3 is greater than 0.6wt% in the total SG of the composition. In some embodiments, RI3 is greater than 0.7wt% in the total SG of the composition. In some embodiments, RI3 is greater than 0.8wt% in the total SG of the composition. In some embodiments, RI3 is greater than 0.9wt% in the total SG of the composition. In some embodiments, RI3 is 0.4-1wt% in the total SG of the composition. In some embodiments, RI3 is not present in the composition.

[0018] In some embodiments, the composition further comprises RJ. In some embodiments, RJ is greater than 0.1wt% in the total SG of the composition. In some embodiments, RI3 is greater than 0.2wt% in the total SG of the composition. In some embodiments, RI3 is greater than 0.3wt% in the total SG of the composition. In some embodiments, RI3 is greater than 0.4wt% in the total SG of the composition. In some embodiments, RI3 is greater than 0.5wt% in the total SG of the composition. In some embodiments, RI3 is greater than 0.6wt% in the total SG of the composition. In some embodiments, RJ is 0.1-0.7wt% in the total SG of the composition.

[0019] In some embodiments, the composition further comprises RK. In some embodiments, RK is greater than 0.1wt% in the total SG of the composition. In some embodiments, RK is greater than 0.2wt% in the total SG of the composition. In some embodiments, RK is greater than 0.3wt% in the total SG of the composition. In some embodiments, RK is greater than 0.4wt% in the total SG of the composition. In some embodiments, RK is greater than 0.5wt% in the total SG of the composition. In some embodiments, RK is greater than 0.6wt% in the total SG of the composition. In some embodiments, RK is greater than 0.7wt% in the total SG of the composition. In some embodiments, RK is 0.3-0.8wt% in the total SG of the composition.

[0020] In some embodiments, the composition further comprises RK2. In some embodiments, RK2 is greater than 0.1 wt% in the total SG of the composition. In some embodiments, RK2 is greater than 0.2 wt% in the total SG of the composition. In some embodiments, RK2 is greater than 0.3 wt% in the total SG of the composition. In some embodiments, RK2 is greater than 0.4 wt% in the total SG of the composition. In some embodiments, RK2 is 0-0.5 wt% in the total SG of the composition.

[0021] In some embodiments, the composition further comprises RL. In some embodiments, RL is greater than 0 wt% of the total SG of the composition. In some embodiments, RL is greater than 0.1 wt% of the total SG of the composition. In some embodiments, RL is greater than 0.2 wt% of the total SG of the composition. In some embodiments, RL is greater than 0.3 wt% of the total SG of the composition. In some embodiments, RL is 0-0.4 wt% of the total SG of the composition.

[0022] In some embodiments, the composition further comprises RT. In some embodiments, RT is greater than 0.1wt% in the total SG of the composition. In some embodiments, RT is greater than 0.2wt% in the total SG of the composition. In some embodiments, RT is greater than 0.3wt% in the total SG of the composition. In some embodiments, RT is greater than 0.4wt% in the total SG of the composition. In some embodiments, RT is greater than 0.5wt% in the total SG of the composition. In some embodiments, RT is greater than 0.6wt% in the total SG of the composition. In some embodiments, RT is greater than 0.7wt% in the total SG of the composition. In some embodiments, RT is greater than 0.8wt% in the total SG of the composition. In some embodiments, RT is greater than 0.9wt% in the total SG of the composition. In some embodiments, RT is 0-1wt% in the total SG of the composition.

[0023] In some embodiments, the composition further comprises RU. In some embodiments, RU is greater than 0.1wt% in the total SG of the composition. In some embodiments, RU is greater than 0.2wt% in the total SG of the composition. In some embodiments, RU is greater than 0.2wt% in the total SG of the composition. In some embodiments, RU is greater than 0.3wt% in the total SG of the composition. In some embodiments, RU is greater than 0.4wt% in the total SG of the composition. In some embodiments, RU is 0.1-0.5wt% in the total SG of the composition.

[0024] In some embodiments, the composition further comprises RU2. In some embodiments, RU2 is greater than 0.1 wt% of the total SG of the composition. In some embodiments, RU2 is greater than 0.2 wt% of the total SG of the composition. In some embodiments, RU2 is greater than 0.3 wt% of the total SG of the composition. In some embodiments, RU2 is greater than 0.4 wt% of the total SG of the composition. In some embodiments, RU2 is 0-0.5 wt% of the total SG of the composition.

[0025] In some embodiments, the composition further comprises RV. In some embodiments, RV is greater than 0wt% in the total SG of the composition. In some embodiments, RV is greater than 0.1wt% in the total SG of the composition. In some embodiments, RV is greater than 0.2wt% in the total SG of the composition. In some embodiments, RV is greater than 0.3wt% in the total SG of the composition. In some embodiments, RV is 0-0.4wt% in the total SG of the composition.

[0026] In some embodiments, the composition further comprises RV2. In some embodiments, RV2 is greater than 0wt% in the total SG of the composition. In some embodiments, RV2 is greater than 0.1wt% in the total SG of the composition. In some embodiments, RV2 is greater than 0.2wt% in the total SG of the composition. In some embodiments, RV2 is greater than 0.3wt% in the total SG of the composition. In some embodiments, RV2 is greater than 0.4wt% in the total SG of the composition. In some embodiments, RV2 is greater than 0.5wt% in the total SG of the composition. In some embodiments, RV2 is 0-0.6wt% in the total SG of the composition.

[0027] In some embodiments, the composition further comprises RW. In some embodiments, RW is greater than 0.1 wt% in the total SG of the composition. In some embodiments, RW is greater than 0.2 wt% in the total SG of the composition. In some embodiments, RW is greater than 0.3 wt% in the total SG of the composition. In some embodiments, RW is greater than 0.4 wt% in the total SG of the composition. In some embodiments, RW is 0-0.5 wt% in the total SG of the composition.

[0028] In some embodiments, the composition further comprises RW2 / 3. In some embodiments, RW2 / 3 is greater than 0.1 wt% of the total SG of the composition. In some embodiments, RW2 / 3 is 0-0.2 wt% of the total SG of the composition.

[0029] In some embodiments, the composition further comprises RY. In some embodiments, RY is greater than 0 wt% of the total SG of the composition. In some embodiments, RY is greater than 0.1 wt% of the total SG of the composition. In some embodiments, RY is greater than 0.2 wt% of the total SG of the composition. In some embodiments, RY is greater than 0.3 wt% of the total SG of the composition. In some embodiments, RY is 0-0.4 wt% of the total SG of the composition.

[0030] In some embodiments, the SG compositions described herein can be mixed with each other in any combination for different taste profiles. In further embodiments, the SG compositions listed in Tables 15-27 and 30-33 can be mixed with each other in any combination for different taste profiles.

[0031] In some embodiments, any one or any combination of the SG compositions described herein can be used as a raw material or starting material for enzymatic processing such as glycosylation to further obtain alternative flavor and taste stevia products.

[0032] In certain embodiments, a certain percentage of each SG having a molecular weight greater than 965 Daltons is present in the composition to produce a sugar-like taste profile and a full mouthfeel.

[0033] In some embodiments, a composition comprising a SG having a molecular weight greater than 965 Daltons has increased solubility in aqueous solution compared to a composition not comprising a SG having a molecular weight greater than 965 Daltons.

[0034] In some embodiments, the composition further comprises one or more non-SG sweeteners.

[0035] In some embodiments, the composition further comprises one or more salts.

[0036] In preferred embodiments, the composition comprises trace or undetectable amounts of non-SG off-flavor components.

[0037] The application on the other hand relates to an oral consumable composition comprising the application composition. In some embodiments, the oral consumable composition is a sweetener. In other embodiments, the oral consumable composition is a flavoring agent. In some embodiments, one or more SGs having a molecular weight greater than 965 daltons account for at least 5ppm, 10ppm, 20ppm, 30ppm, 40ppm, 50ppm, 60ppm, 70ppm, 80ppm, 90ppm, 100ppm, 150ppm, 200ppm, 300ppm, 400ppm, 600ppm, 800ppm, 1000ppm or 1200ppm of the oral consumable composition total amount.

[0038] Another aspect of the present application relates to a composition comprising the SG in Table A, wherein the composition comprises one or more high molecular weight SG. In some embodiments, the composition comprises one or more high molecular weight SG for improving the solubility of other SG components. In some embodiments, the composition comprises one or more high molecular weight SG for improving the taste profile of other SG components. In some embodiments, other SG components include or are mainly composed of ST, RA, RC, RB, RD, RE and DA.

[0039] Another aspect of the present application relates to a method for preparing a SG composition having an improved taste profile and increased solubility compared to an untreated SG composition. The method comprises the steps of mixing SG or a SG composition with water to form a mixture; heating the mixture until the mixture forms a solution; cooling the solution to ambient temperature; and drying the solution. In some embodiments, the drying is spray drying. In specific embodiments, the method further comprises the step of removing non-steviol off-flavor compounds. In some further embodiments, the off-flavor compounds have a bitter taste.

[0040] Another aspect of the present application relates to a method for increasing the sweetness of an oral consumable composition, comprising the step of adding an effective amount of any one of the compositions described above to the oral consumable composition.

[0041] Another aspect of the present application relates to a method for increasing the taste or flavor of an oral consumable composition, comprising the step of adding an effective amount of any one of the compositions described above to the oral consumable composition.

[0042] On the other hand, the present application relates to a composition comprising one or more SGs, wherein the SG has a parent structure of formula II or formula III; wherein R1 and R2 are substituents selected from glucosyl (G), rhamnosyl (R), xylosyl (X), deoxyglucosyl (dG), fructosyl (F), arabinosyl (A), galactosyl (Ga) or any combination of the above groups, wherein the number of glucosyl groups is equal to or greater than 4.

[0043] In some embodiments, the number of rhamnosyl groups is equal to or greater than one.

[0044] In some embodiments, the number of xylosyl groups is equal to or greater than one.

[0045] In some embodiments, the number of deoxyglucosyl groups is equal to or greater than one.

[0046] In some embodiments, the number of fructosyl groups is equal to or greater than one.

[0047] In some embodiments, the number of arabinosyl groups is equal to or greater than one.

[0048] In some embodiments, the number of galactosyl groups is equal to or greater than one.

[0049] In some embodiments, the one or more SGs are selected from the group consisting of: related SG#2, related SG#5, RU2, RT, RW, RW2, RW3, RU, SG-12, RH, RJ, RK, RK2, SG-Unk4, SG-Unk5, RD, RI, RL, RI3, SG-Unk6, RQ, RI2, RQ2, RQ3, RT1, related SG#4, RV2, RV, RY, RN, RM, 15α-OH RM, RO and RO2.

[0050] In some embodiments, the total SG content is greater than 80 wt % of the composition.

[0051] In some embodiments, the total SG content is greater than 90 wt % of the composition.

[0052] In some embodiments, the one or more SGs are present in an amount of 0.1-99.9 wt % of the total SGs in the composition.

[0053] In some embodiments, one or more SGs are present in the composition in a total amount of 1-30 wt % of the composition.

[0054] In some embodiments, one or more SGs are present in the composition in a total amount of 6-23 wt % of the composition.

[0055] In some embodiments, RD is 1.0-10.0 wt % of the total SG in the composition.

[0056] In some embodiments, RD is 2.0-8.0 wt % of the total SG in the composition.

[0057] In some embodiments, RO is 0.2-1.5 wt % of the total SG in the composition.

[0058] In some embodiments, RK is 1-5 wt % of the total SG in the composition.

[0059] In some embodiments, RV is 0-0.6 wt % of the total SG in the composition.

[0060] In some embodiments, RT is 0-0.9 wt % of the total SG in the composition.

[0061] In some embodiments, RN is 0-0.3 wt % of the total SG in the composition.

[0062] In some embodiments, RM is 0-0.4 wt % of the total SG in the composition.

[0063] In some embodiments, RJ is 0-0.3 wt % of the total SG in the composition.

[0064] In some embodiments, RW is 0-0.4 wt % of the total SG in the composition.

[0065] In some embodiments, RU2 is 0-0.5 wt % of the total SG in the composition.

[0066] In some embodiments, RY is 0-0.3 wt % of the total SG in the composition.

[0067] In some embodiments, the RI is 0-0.3 wt % of the total SG in the composition.

[0068] In some embodiments, RV2 is 0-0.5 wt % of the total SG in the composition.

[0069] In some embodiments, RK2 is 0-0.5 wt % of the total SG in the composition.

[0070] In some embodiments, RH is 0-0.3 wt % of the total SG in the composition.

[0071] Another aspect of the present application relates to a composition comprising RA and any of the above compositions comprising one or more SG, wherein SG has a parent structure of formula II or III; wherein R1 and R2 are substituents selected from glucosyl (G), rhamnosyl (R), xylosyl (X), deoxyglucosyl (dG), fructosyl (F), arabinosyl (A), galactosyl (Ga) or any combination of the above groups, wherein the number of glucosyl groups is equal to or greater than 4.

[0072] In some embodiments, RA is 15-50 wt % of the total SG in the composition.

[0073] In some embodiments, RA is 25-35 wt % of the total SG in the composition.

[0074] In some embodiments, the composition further comprises ST.

[0075] In some embodiments, ST is 20-70 wt % of the total SG in the composition.

[0076] In some embodiments, ST is 20-45 wt % of the total SG in the composition.

[0077] On the other hand, the present application relates to a sweetener composition comprising any one or more of the above-mentioned SG compositions, wherein SG has a parent structure of formula II or formula III; wherein R1 and R2 are substituents selected from glucosyl (G), rhamnosyl (R), xylosyl (X), deoxyglucosyl (dG), fructosyl (F), arabinosyl (A), galactosyl (Ga) or any combination of the above groups, wherein the number of glucosyl groups is equal to or greater than 4.

[0078] In some embodiments, the sweetener composition is dissolved in an aqueous solution. In some further embodiments, the sweetener composition is present in the solution at a concentration of less than 1500ppm, less than 1000ppm, less than 700ppm, less than 400ppm or less than 200ppm. In other further embodiments, the sweetener composition is present in the solution at a concentration of at least 100ppm.

[0079] In some embodiments, the sweetener compositions have improved properties compared to RA, including lingering sweetness and upfront sweetness.

[0080] Another aspect of the present application relates to a flavor composition, which comprises any of the above-mentioned compositions containing one or more SGs, wherein SG has a parent structure of formula II or formula III; wherein R1 and R2 are substituents selected from glucosyl (G), rhamnosyl (R), xylosyl (X), deoxyglucosyl (dG), fructosyl (F), arabinosyl (A), galactosyl (Ga) or any combination of the above groups, wherein the number of glucosyl groups is equal to or greater than 4.

[0081] In some embodiments, the flavor composition is dissolved in an aqueous solution. In some further embodiments, the flavor composition is present in the solution at a concentration of 0-30 ppm, preferably 0-10 ppm, more preferably 5-10 ppm.

[0082] In some embodiments, the flavor composition adds sweetness.

[0083] In some embodiments of the flavor composition, the number of rhamnosyl groups is equal to or greater than 1, and / or the number of xylosyl groups is equal to or greater than 1, and / or the number of deoxy-glucosyl groups is equal to or greater than 1, and / or the number of fructosyl groups is equal to or greater than 1, and / or the number of arabinosyl groups is equal to or greater than 1, and / or the number of galactosyl groups is equal to or greater than 1.

[0084] In some embodiments of the flavor composition, one or more SGs are selected from: related SG#2, related SG#5, RU2, RT, RW, RW2, RW3, RU, SG-12, RH, RJ, RK, RK2, SG-Unk4, SG-Unk5, RD, RI, RL, RI3, SG-Unk6, RQ, RI2, RQ2, RQ3, RT1, related SG#4, RV2, RV, RY, RN, RM, 15α-OH RM, RO and RO2.

[0085] In some embodiments, the total amount of SG is 50-90 wt % of the flavor composition.

[0086] In some embodiments, RD is 0.2-9 wt % of the flavor composition.

[0087] In some embodiments, the RM is 0.1-4.0 wt % of the flavor composition.

[0088] In some embodiments, the RU is 0.1-3.0 wt % of the flavor composition.

[0089] In some embodiments, the flavor composition further comprises RA and STV. In some further embodiments, RA is 20-30 wt % of the flavor composition. In other further embodiments, STV is 8-40 wt % of the flavor composition.

[0090] In some embodiments, the flavor composition further comprises RF, RC, Dulc A, RB, and STB.

[0091] In some embodiments, the flavor composition is dissolved in an aqueous solution. In some further embodiments, the flavor composition is present in the solution at a concentration of less than 60 ppm, less than 70 ppm, less than 75 ppm, less than 100 ppm, less than 200 ppm or less than 300 ppm.

[0092] Another aspect of the present application relates to a composition comprising two groups of SG. The first group of SG is selected from one or more SGs having a parent structure of formula II or III; wherein R1 and R2 are substituents selected from glucosyl (G), rhamnosyl (R), xylosyl (X), deoxyglucosyl (dG), fructosyl (F), arabinosyl (A), galactosyl (Ga) or any combination of the above groups, wherein the number of glucosyl groups is equal to or greater than 4, and optionally, the number of rhamnosyl groups is equal to or greater than 1, and / or the number of xylosyl groups is equal to or greater than 1, and / or the number of deoxyglucosyl groups is equal to or greater than 1, and / or the number of fructosyl groups is equal to or greater than 1, and / or the number of arabinosyl groups is equal to or greater than 1, and / or the number of galactosyl groups is equal to or greater than 1. The second group of SG comprises one or more SGs substantially selected from RA, RB, stevioside, RC, RD, RM or a combination thereof. The content of the first group of SG in the total SG is 1-30 wt%.

[0093] In some embodiments, the weight ratio of the first group and the second group SG is 1:99, 2:98, 3:97, 4:96, 5:95, 6:94, 7:93, 8:94, 9:91, 10:90, 11:89, 12:88, 13:87, 14:86, 15:85, 16:84, 17:83, 18:82, 19:81, 20:80, 21:79, 22:78, 23: 77, 24:76, 25:75, 26:74, 27:73, 28:72, 29:71, 30:70, 31:69, 32:68, 33:67, 34:66, 35:65, 36:64, 37:63, 38:62, 39:61, 40:60, 41:59, 42:58, 43:57, 44:56, 45:55, 46:54, 47:53, 48: 52, 49:51, 50:50, 51:49, 52:48, 53:47, 54:45, 55:45, 56:44, 57:43, 58:42, 59:41, 60:40, 61:39, 62:38, 63:37, 64:36, 65:35, 66:37, 67:33, 68:32, 69:31, 70:30, 71:29, 72:28, 73: 27, 74:26, 75:25, 76:24, 77:23, 78:22, 79:21, 80:20, 81:19, 82:18, 83:17, 84:16, 85:15, 86:14, 87:13, 88:12, 89:11, 90:10, 91:9, 92:8, 93:7, 94:6, 95:5, 96:4, 97:3, 98:2 or 99:1.

[0094] In some embodiments, ST is 14-40 wt % of the total SG in the composition.

[0095] In some embodiments, the one or more SGs in the first group of SGs are selected from related SG#2, related SG#5, RU2, RT, RW, RW2, RW3, RU, SG-12, RH, RJ, RK, RK2, SG-Unk4, SG-Unk5, RD, RI, RL, RI3, SG-Unk6, RQ, RI2, RQ2, RQ3, RT1, related SG#4, RV2, RV, RY, RN, RM, 15α-OH RM, RO and RO2.

[0096] In some embodiments, the number of rhamnosyl groups is equal to or greater than 1; and / or the number of xylosyl groups is equal to or greater than 1; and / or the number of deoxyglucosyl groups is equal to or greater than 1; and / or the number of fructosyl groups is equal to or greater than 1; and / or the number of arabinosyl groups is equal to or greater than 1; and / or the number of galactosyl groups is equal to or greater than 1.

[0097] In some embodiments, the amount of RA included in the composition is 10-80wt%, preferably 20-70wt%; and / or, the amount of RB included in the composition is 0-30wt%, preferably 0.1-25wt%; and / or, the amount of RC included in the composition is 0-30wt%, preferably 0.1-25wt%; and / or, the amount of RD included in the composition is 0-30wt%, preferably 0.1-25wt%; and / or, the amount of RM included in the composition is 0-30wt%, preferably 0.1-25wt%.

[0098] In some embodiments, the composition comprises one or more SGs having a molecular weight equal to or greater than 1097 Daltons and combinations thereof, and the content of the SG is 0-30 wt%, preferably 0.1-20 wt%.

[0099] In some embodiments, the composition comprises one or more SGs having a molecular weight equal to or greater than 1111 Daltons and combinations thereof, and the content of the SG is 0-30 wt%, preferably 0.1-20 wt%.

[0100] In some embodiments, the composition comprises one or more SGs having a molecular weight equal to or greater than 1127 Daltons and combinations thereof, and the content of the SG is 0-30 wt%, preferably 0.1-20 wt%.

[0101] In some embodiments, the composition comprises one or more SGs having a molecular weight equal to or greater than 1259 Daltons and combinations thereof, and the content of the SG is 0-30 wt%, preferably 0.1-20 wt%.

[0102] In some embodiments, the composition comprises one or more SGs having a molecular weight equal to or greater than 1273 Daltons and combinations thereof, and the content of the SG is 0-30 wt%, preferably 0.1-20 wt%.

[0103] In some embodiments, the composition comprises one or more SGs having a molecular weight equal to or greater than 1289 Daltons and combinations thereof, and the content of the SG is 0-30 wt%, preferably 0.1-20 wt%.

[0104] In some embodiments, the composition comprises one or more SGs having a molecular weight equal to or greater than 1305 Daltons and combinations thereof, and the content of the SG is 0-30 wt%, preferably 0.1-20 wt%.

[0105] In some embodiments, the composition comprises one or more SGs having a molecular weight equal to or greater than 1435 Daltons and combinations thereof, and the content of the SG is 0-30 wt%, preferably 0.1-20 wt%.

[0106] In some embodiments, one or more SGs in the first group of SGs contain: 0-30wt% of the total SG in the composition, preferably 0.1-25wt% of the relevant SG#2; and / or, 0-30wt% of the total SG in the composition, preferably 0.1-25wt% of the relevant relevant SG#5; and / or, 0-30wt% of the total SG in the composition, preferably 0.1-25wt% of RU2; and / or, 0-30wt% of the total SG in the composition, preferably 0.1-25wt% of RT; and / or, 0-30wt% of the total SG in the composition, preferably 0.1-25wt% of RW; and / or, 0-30wt% of the total SG in the composition, preferably 0.1-25wt% of 30wt% of RW2, preferably 0.1-25wt%; and / or, 0-30wt% of RW3, preferably 0.1-25wt% of the total SG in the composition; and / or, 0-30wt% of RU, preferably 0.1-25wt% of the total SG in the composition; and / or, 0-30wt% of SG-12, preferably 0.1-25wt% of the total SG in the composition; and / or, 0-30wt% of RH, preferably 0.1-25wt% of the total SG in the composition; and / or, 0-30wt% of RJ, preferably 0.1-25wt% of the total SG in the composition; and / or, 0-30wt% of RK, preferably 0.1-25wt% of the total SG in the composition, Preferably 0.1-25wt%; and / or, RK2 accounting for 0-30wt% of the total SG in the composition, preferably 0.1-25wt%; and / or, SG-Unk4 accounting for 0-30wt% of the total SG in the composition, preferably 0.1-25wt%; and / or, SG-Unk5 accounting for 0-30wt% of the total SG in the composition, preferably 0.1-25wt%; and / or, RI accounting for 0-30wt% of the total SG in the composition, preferably 0.1-25wt%; and / or, RL accounting for 0-30wt% of the total SG in the composition, preferably 0.1-25wt%; and / or, RI3 accounting for 0-30wt% of the total SG in the composition, preferably 0.1-25wt%; and / or, SG-Unk6 accounting for 0-30wt% of the total SG in the composition, preferably 0.1-25wt%; and / or, RQ accounting for 0-30wt% of the total SG in the composition, preferably 0.1-25wt%; and / or, RQ2 accounting for 0-30wt% of the total SG in the composition, preferably 0.1-25wt%; and / or, RQ3 accounting for 0-30wt% of the total SG in the composition, preferably 0.1-25wt%; and / or, RT1 accounting for 0-30wt% of the total SG in the composition, preferably 0.1-25wt%; and / or, the related SG#4 accounting for 0-30wt% of the total SG in the composition, preferably 0.1-25wt%; and / or, RV accounting for 0-30wt% of the total SG in the composition, preferably 0.1-25wt%; and / or, RV2 accounting for 0-30wt% of the total SG in the composition, preferably 0.1-25wt%; and / or, RY accounting for 0-30wt% of the total SG in the composition, preferably 0.1-25wt%; and / or, 15α-OH RM accounting for 0-30wt% of the total SG in the composition, preferably 0.1-25wt%; and / or, RO2 accounting for 0-30wt% of the total SG in the composition, preferably 0.1-25wt%. .

[0107] In some embodiments, the compositions have an improved taste profile including aftertaste, bitterness, and / or linger.

[0108] In some embodiments, the composition has enhanced solubility in aqueous solutions.

[0109] In some embodiments, the composition further comprises one or more non-SG sweeteners.

[0110] In some embodiments, the composition further comprises one or more salts.

[0111] In some embodiments, the composition comprises trace amounts of non-SG off-flavor components.

[0112] In some embodiments, the composition is a sweetener.

[0113] In some embodiments, the composition is a flavorant.

[0114] In some embodiments, the method for preparing the composition comprises the following steps:

[0115] dissolving the crude extract in a first ethanol-water solution to form a mixture;

[0116] The mixture is heated until the mixture becomes a solution;

[0117] The solution was cooled to ambient temperature;

[0118] separating the supernatant and the precipitate of the solution;

[0119] drying the supernatant to form a powder;

[0120] dissolving the powder with water to form a second solution;

[0121] treating the second solution with a macroporous resin to obtain a material;

[0122] The material was desorbed with a second aqueous ethanol solution.

[0123] In some embodiments, the concentration of the second ethanol aqueous solution is greater than 0 and less than 50 wt %, preferably 20-50 wt %, and more preferably 25-35 wt %.

[0124] In some embodiments, the concentration of the second ethanol aqueous solution is 50-100 wt %, preferably 60-80 wt %, more preferably 65-75 wt %.

[0125] In some embodiments, the composition is used in an orally consumable product.

[0126] In some embodiments, the composition is used in candies, condiments, chewing compositions, cereal compositions, baked goods, dairy products and sweetener compositions thereof, beverages and drinks, pharmaceutical compositions, smoked compositions or oral hygiene compositions. BRIEF DESCRIPTION OF THE DRAWINGS

[0127] Figure 1 Shown is the powder XRD pattern of sample 094-39-01.

[0128] Figure 2 Shown is the powder XRD pattern of sample 094-39-02.

[0129] Figure 3 Shown is a schematic diagram of the analytical methodology used to determine SG and its amount in mother liquor samples.

[0130] Figure 4 is the HPLC standard curve of STB.

[0131] Figure 5 is the HPLC standard curve of RA.

[0132] Figure 6 is the HPLC standard curve of RD.

[0133] Figure 7 It is a spectrum peak identification diagram.

[0134] Figure 8 is a HPLC analysis chart of the exemplary composition of Table 10 of the present invention.

[0135] Fig. 9 is a chromatogram of the total ion current of an exemplary composition of Table 10 of the present invention.

[0136] Fig.10 is a HPLC analysis chart of the exemplary composition of Table 11 of the present invention.

[0137] Fig.11 is a chromatogram of the total ion current of an exemplary composition of Table 11 of the present invention.

[0138] Fig.12is a HPLC analysis chart of the exemplary composition of Table 12 of the present invention.

[0139] Fig.13 is a chromatogram of the total ion current of an exemplary composition of Table 12 of the present invention.

[0140] Fig.14 is a HPLC analysis chart of the exemplary composition of Table 13 of the present invention.

[0141] Fig.15 is a chromatogram of the total ion current of an exemplary composition of Table 13 of the present invention.

[0142] Fig.16 is a HPLC analysis chart of the exemplary composition of Table 14 of the present invention.

[0143] Fig.17 is a chromatogram of the total ion current of an exemplary composition of Table 14 of the present invention.

[0144] Fig.18 is a HPLC analysis chart of the exemplary composition of Table 15 of the present invention.

[0145] Fig.19A is an exemplary general sweetness profile. Fig.19B is the sweetness profile of a 5% sucrose solution.

[0146] Fig. 20A is the sweetness profile of sample composition #3 (Table 16). Fig. 20B is the sweetness profile of sample composition #4 (Table 17). Fig. 20C is the sweetness profile of sample composition #11 (Table 24). Fig.20D is the sweetness profile of sample composition #12 (Table 25).

[0147] Fig.21A are chromatograms corresponding to the compositions shown in Tables 62 and 63 (upper trace: FEML, lower trace: SEML).

[0148] Fig.21B It is the chromatogram UV detection chart corresponding to the composition shown in Table 62 and 63 (upper trace: FEML, lower trace: SEML). DETAILED DESCRIPTION OF THE INVENTION

[0150] Throughout the specification and claims, the terms "comprising" and "including" are open-ended terms and should be understood to mean "including, but not limited to... ." These terms encompass the more restrictive terms "consisting essentially of and "consisting of.

[0151] It should be noted that when used herein and in the appended claims, the singular forms "a", "an", and "the" include plural references unless the context clearly dictates otherwise. Furthermore, the terms "a", "one or more", and "at least one" may be used interchangeably herein. It should also be noted that the terms "comprising", "including", "characterized by", and "having" may be used interchangeably.

[0152] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as those generally understood by those of ordinary skill in the art to which the present invention belongs. All publications and patents explicitly mentioned herein are incorporated herein by reference for all purposes, including describing and disclosing chemicals, instruments, statistical analyses and methods reported in publications that may be associated with the present invention. All references cited in this specification will be used to indicate the state of the art in the field. Nothing herein is to be inferred as an admission that the present invention is disclosed due to prior invention.

[0153] As used herein, the term "rebaudioside" may be abbreviated as "Reb" or "R". For example, the phrase "rebaudioside A" has the same definition as "RebA" and "RA". This applies to all rebaudioside. Similarly, the term "dulcoside" may be abbreviated as "Dul" or "D" with reference to DA, DAl or DB.

[0154] The phrase "SG" is well known in the art and is intended to include the major and minor components of Stevia as listed in Table 1. These components include, but are not limited to, components of Stevia such as steviol, STB, ST, RA, RB, RC, RD, RE, RF, RM (also known as rebaudioside X (RX)), rubusoside, and dulcoside DA, A1, and B. The SG may be purified prior to use.

[0155] As used herein, "high molecular weight" with respect to SG refers to SG having a molecular weight greater than 965 Daltons.

[0156] The phrase "Stevia containing a sweetener" is meant to include any composition prepared from the stevia plant, such as a stevia extract or a single component found in stevia. The sweetener may include one or more of the ingredients associated with the stevia plant as noted above. The sweetener may also include conventional artificial or natural sweeteners, such as sucrose, glucose, maltose, fructose, mannitol, sorbitol, aspartame, inulin, sucralose, acesulfame potassium, sodium cyclamate, mogrosides and derivatives thereof, and the like.

[0157] The "SG composition" described herein refers to a material containing one or two or more purified SG found in stevia plants or sweet tea plants or stevia extracts or sweet tea extracts. In addition, the "SG composition" may refer to stevia extracts, sweet tea extracts, or "stevia raw materials" described below.

[0158] The phrase "Stevia raw material" or "raw material" refers to a material containing SG of the plant Stevia or other species of Stevia. In some embodiments, the Stevia raw material or raw material can be a crude extract, a purified extract, or a by-product of a purification process. In some other embodiments, the Stevia raw material contains SG derived from a fermentation and / or enzymatic conversion process or other synthetic process. The crude extract is typically the first dry product produced after processing the harvested Stevia plant material. The purified extract contains a higher concentration of one or more target SGs than the crude extract contains. By-products in the purification process are typically waste streams that are derived in whole or in part from a crude extract or a purified SG of intermediate purity.

[0159] The phrase "sucrose equivalent" or "SE" is the amount of non-sugar sweetener required to provide the sweetness of a given sucrose percentage in the same food, beverage or solution. For example, a sugary soft drink typically contains 12g of sucrose per 100ml of water, i.e. 12% sucrose. This means that to be commercially acceptable, a sugar-free soft drink must have the same sweetness as a 12% sucrose soft drink, i.e. the sugar-free soft drink must have an SE of 12%. Soft drink batching equipment is set to 12% SE because such equipment is set up for use with sucrose-based syrups.

[0160] The phrase "taste profile" or "sensory profile" is defined as the temporal profile of all the basic tastes of a sweetener. When a sweetener is consumed, the onset and decay of sweetness is measured by trained human tasters from the time it contacts the taster's tongue ("onset") to the cutoff point (usually 180 seconds after onset), and is called the "temporal profile of sweetness". These human tasters are called "sensory panels". In addition to sweetness, sensory panels may also evaluate the temporal profiles of other "basic tastes": bitterness, saltiness, sourness, spiciness (also known as spicy taste), and umami (also known as aromatic or meaty taste). When a sweetener is consumed, the onset and decay of bitterness is measured by trained human tasters from the time the taste is first felt to the time the aftertaste is last felt at the cutoff point, and is called the "temporal profile of bitterness".

[0161] As used herein, the term "flavor" or "flavor profile" is the combined sensory perception of taste, odor and or texture elements. As used herein, the term "enhance" includes augmenting, intensifying, accentuating, magnifying and potentiating the sensory perception of a flavor profile without changing its essence or nature. As used herein, the term "modify" includes altering, varying, suppressing, depressing, fortifying and supplementing the sensory perception of a flavor profile when the flavor profile lacks quality or duration.

[0162] The solubility disclosed throughout the present invention is "long-term solubility", rather than "initial solubility" as described in the art. Long-term solubility in the present embodiment is different from initial or short-term solubility. In other words, the solutions of the present invention maintain homogeneity for a long time without crystallization, precipitation or solution heterogeneity. In general, the long-term solubility described herein is from at least 1 day to greater than 5 years, from about 5 days to about 2 years, and more particularly from about 30 days to about 1 year. This technology can also be applied to improve the initial solubility of a single SG.

[0163] 1. SG composition with satisfactory solubility and taste profile

[0164] One aspect of the present application relates to SG compositions with satisfactory solubility and / or taste profiles. The SG compositions can be used as sweeteners and / or flavoring agents. In some embodiments, the SG compositions of the present application contain one or more SGs and have significantly enhanced long-term solubility and / or significantly improved taste profiles in water compared to previously reported SG compositions such as purified RA.

[0165] The bitter taste associated with SG compositions is not only a result of SG exceeding the threshold of off-flavor characteristics, such as astringency and bitterness, but also a result of the composition containing non-stevia off-flavor components, such as polyphenols, etc. The inventors have successfully removed the non-stevia off-flavor components through this process, and added steviol glycosides in the composition at a level below the perceptible or orally detectable bitterness of each SG in solution. The inventors surprisingly found that all of this SG tastes more like sugar at all industrially available concentrations.

[0166] In some embodiments, the inventors surprisingly discovered that the long-term solubility of SG or SG compositions can be significantly improved by dissolving SG or SG compositions in water at elevated temperatures and then lowering the temperature to room temperature. The resulting solution is spray dried, wherein the SG or SG composition is stable in water or water / alcohol at ambient temperature for more than 1 day. The term "stable" or "stability" is used throughout the specification without limitation and refers to the duration of solubility of SG or SG compositions dissolved in a solvent. The method provides a stevia extract, a stevia component, or a mixture of treated stevia components.

[0167] In some embodiments, the present invention provides SG compositions with improved solubility and taste profiles, the compositions comprising one or more SGs, one or more non-SG sweeteners and / or one or more additional additives. In some embodiments, the additional additives include, but are not limited to, flavoring agents, salts, minerals, organic and inorganic acids, polyols, nucleotides, bitter compounds, astringent compounds, proteins or protein hydrolysates, surfactants, gums and waxes, antioxidants, polymers, fatty acids, vitamins, preservatives, hydrating agents, and combinations thereof.

[0168] In some embodiments, the present invention provides SG compositions comprising trace or undetectable amounts of non-Stevia substances that impart a bitter taste.

[0169] SG and SG composition

[0170] SG is a glycoside of steviol (a diterpenoid compound shown in Formula I below).

[0171]

[0172] As shown in Formula II, SG may have a mother or core structure comprising a steviol molecule having glycosylation at the C13 and / or C19 position.

[0173]

[0174] As shown in Formula III, steviol glycosides may also have a parent or core structure comprising an isosteviol (Iso-Sv) molecule having glycosylation at C13.

[0175]

[0176] In some embodiments of SG having a parent or core structure of formula II or III, R1 and R2 are substituents selected from groups comprising glucosyl (G), rhamnosyl (R), xylosyl (X), deoxy-glucosyl (dG), fructosyl (F), arabinosyl (A) or galactosyl (Ga), respectively. In some other embodiments, the number of glucosyl groups is equal to or greater than 4. Table A provides a list of about 80SG used in this application.

[0177] Table A.SG

[0178]

[0179]

[0180]

[0181]

[0182]

[0183]

[0184]

[0185] Exemplary SGs include, for example, ST, STB, RA, RB, RC, RD, RE, RF, RM, rubusoside, and dulcoside A. Additional SGs include, but are not limited to, SG1-16 (SGs without a specific name); SG-Unk1-6 (SGs without detailed structural evidence); glycosylated SGs (GSGs), steviol monosaccharides, isosteviol biosaccharides, iso-RB, iso-ST, dulcoside B, RG, RK, RR, RI, RL, RT, RN, 15α-OH RM, RL, RS, and RO.

[0186] The one or more SGs contained in the SG composition of the present application may account for about 1 wt % to about 99 wt % of the SG composition, specifically about 1 wt %, about 2 wt %, about 3 wt %, about 4 wt %, about 5 wt %, about 6 wt %, about 7 wt %, about 8 wt %, about 9 wt %, about 10 wt %, about 11 wt %, about 12 wt %, about 13 wt %, about 14 wt %, about 15 wt %, about 16 wt %, about 17 wt %, about 18 wt %, about 19 wt %, about 20 wt %, about 21 wt %, about 22 wt %, about 23 wt %, about 24 wt %, about 25 wt %, about 26 wt %, about 27 wt %, about 28 wt %, about 29 wt %, about 30 wt %, about 31 wt %, about 32 wt %, about 33 wt %, about 34 wt %, about 35 wt %, about 36 wt %, about 37 wt %, about 38 wt %, about 39 wt %, about 40 wt %, about 41 wt %, about 42 wt %, about 43 wt %, about 44 wt %, about 3wt%, about 24wt%, about 25wt%, about 26wt%, about 27wt%, about 28wt%, about 29wt%, about 30wt%, about 31wt%, about 32wt%, about 33wt%, about 34wt%, about 35wt%, about 36wt%, about 37wt%, about 38wt%, about 39wt%, about 40wt%, about 41wt%, about 42wt%, about 43wt%, about 44wt%, about 45wt%, about 46wt%, about 47wt%, about 48wt%, about 49wt%, about 50wt%, about 51wt%, about 52wt%, about 53wt%, about 54wt%, about 55wt%, about 56wt%, about 57wt%, about 58wt%, about 59wt%, about 60wt%, about 61wt%, about 62wt%, about 63wt%, about 64wt%, about 65wt%, about 6wt%, about 67wt%, about 68wt%, about 69wt%, about 70wt%, about 71wt%, About 72wt%, about 73wt%, about 74wt%, about 75wt%, about 76wt%, about 77wt%, about 78wt%, about 79wt%, about 80wt%, about 81wt%, about 82wt%, about 83wt%, about 84wt%, about 85wt%, about 86wt%, about 87wt%, about 88wt%, about 89wt%, about 90wt%, about 91wt%, about 92wt%, about 93wt %, about 94 wt%, about 95 wt%, about 96 wt%, about 97 wt%, about 98 wt%, about 99 wt% and all ranges therebetween, for example, including about 40 wt% to about 45 wt%, 40 wt% to about 50 wt%, 40 wt% to about 55 wt%, 40 wt% to about 60 wt%, 40 wt% to about 65 wt%, 40 wt% to about 70 wt%, 40 wt% to about 75 wt%, 40 wt% to about 80 wt%, 40 wt% to about 85 wt%, 40 wt% to about 90 wt%, 40 wt% to about 95 wt%, 40 wt% to about 97 wt%, 40 wt% to about 99 wt%, 45 wt% to about 50 wt%, 45 wt% to about 55 wt%, 45 wt% to about 60 wt%, 45 wt% to about 65 wt%, 45 wt% to about 70 wt%, 45 wt% to about 75 wt%,45 wt% to about 80 wt%, 45 wt% to about 85 wt%, 45 wt% to about 90 wt%, 45 wt% to about 95 wt%, 45 wt% to about 97 wt%, 45 wt% to about 99 wt%, 50 wt% to about 55 wt%, 50 wt% to about 60 wt%, 50 wt% to about 65 wt%, 50 wt% to about 70 wt%, 50 wt% to about 75 wt%, 50 wt% to about 80 wt%, 50 wt% to about 85 wt%, 50 wt% to about 90 wt%, 50 wt% to about 95 wt%, 50 wt% to about 97 wt%, 50 wt% to about 99 wt%, 55 wt% to about 60 %, 55 wt% to about 65 wt%, 55 wt% to about 70 wt%, 55 wt% to about 75 wt%, 55 wt% to about 80 wt%, 55 wt% to about 85 wt%, 55 wt% to about 90 wt%, 55 wt% to about 95 wt%, 55 wt% to about 97 wt%, 55 wt% to about 99 wt%, 60 wt% to about 65 wt%, 60 wt% to about 70 wt%, 60 wt% to about 75 wt%, 60 wt% to about 80 wt%, 60 wt% to about 85 wt%, 60 wt% to about 90 wt%, 60 wt% to about 95 wt%, 60 wt% to about 97 wt%, 60 wt% to about 99 wt%, % to about 99wt%, 65wt% to about 70wt%, 65wt% to about 75wt%, 65wt% to about 80wt%, 65wt% to about 85wt%, 65wt% to about 90wt%, 65wt% to about 95wt%, 65wt% to about 97wt%, 65wt% to about 99wt%, 70wt% to about 75wt%, 70wt% to about 80wt%, 70wt% to about 85wt%, 70wt% to about 90wt%, 70wt% to about 95wt%, 70wt% to about 97wt%, 70wt% to about 99wt%, 75wt% to about 80wt%, 75wt% to about 85wt%, 75wt% to about 90wt%, % to about 90wt%, 75wt% to about 95wt%, 75wt% to about 97wt%, 75wt% to about 99wt%, 80wt% to about 85wt%, 80wt% to about 90wt%, 80wt% to about 95wt%, 80wt% to about 97wt%, 80wt% to about 99wt%, 85wt% to about 90wt%, 85wt% to about 95wt%, 85wt% to about 97wt%, 85wt% to about 99wt%, 90wt% to about 95wt%, 90wt% to about 97wt%, 90wt% to about 99wt%, 95wt% to about 97wt%, and 95wt% to about 99wt%.

[0187] In some embodiments, the amount of RA included in the one or more SGs in the composition is 10-80wt%, 10-70wt%, 10-60wt%, 10-50wt%, 10-40wt%, 10-30wt%, 10-20wt%, 20-80wt%, 20-70wt%, 20-60wt%, 20-50wt%, 20-40wt%, 20-35wt%, 20-30wt%, 20-25wt%, 25-80wt%, 25-70wt%. , 25-60wt%, 25-50wt%, 25-40wt%, 25-30wt%, 30-80wt%, 30-70wt%, 30-60wt%, 30-50wt%, 30-40wt%, 30-35wt% , 40-80wt%, 40-70wt%, 40-60wt%, 40-50wt%, 50-80wt%, 50-70wt%, 50-60wt%, 60-80wt%, 60-70wt% or 70-80wt%.

[0188] In some embodiments, the amount of RB included in the one or more SGs in the composition is 0-30wt%, 0-25wt%, 0-20wt%, 0-15wt%, 0-10wt%, 0-8wt%, 0-5wt%, 0-2wt%, 0-1wt%, 0-0.5wt%, 0.1-30wt%, 0.1-25wt%, 0.1-20wt%, 0.1-15wt%, 0.1-10wt%, 0.1-8wt%, 0.1-5wt%, 0.1-2wt%, 0.1-1wt%, 0.1-0.5wt%, 0.5-30wt%, 0.5-25wt%, 0.5-20wt%, 0.5-15wt%, 0.5-10wt%, 0.5-8wt%, 0.5-5wt%, 0.5-2wt%. , 0.5-1wt%, 1-30wt%, 1-25wt%, 1-20wt%, 1-15wt%, 1-10wt%, 1-8wt%, 1-5wt%, 1-2wt% , 1.5-30wt%, 1.5-25wt%, 1.5-20wt%, 1.5-15wt%, 1.5-10wt%, 1.5-8wt%, 1.5-5wt%, 5 %, 5-10wt%, 5-8wt%, 10-30wt%, 10-25wt%, 10-20wt%, 10-15wt%, 15-30wt%, 15-25wt%, 15-20wt%, 20-30wt%, 20-25wt% or 25-30wt% and combinations thereof. In certain embodiments, the composition has no RB or substantially no RB.

[0189] In some embodiments, the amount of RC included in the one or more SGs in the composition is 0-30wt%, 0-25wt%, 0-20wt%, 0-15wt%, 0-10wt%, 0-8wt%, 0-5wt%, 0-2wt%, 0-1wt%, 0-0.5wt%, 0.1-30wt%, 0.1-25wt%, 0.1-20wt%, 0.1-15wt%, 0.1-10wt%. t%, 0.1-8wt%, 0.1-5wt%, 0.1-2wt%, 0.1-1wt%, 0.1-0.5wt%, 0.5-30wt%, 0.5-25wt%, 0.5-20 wt%, 0.5-15wt%, 0.5-10wt%, 0.5-8wt%, 0.5-5wt%, 0.5-2wt%, 0.5-1wt%, 1-30wt%, 1-25wt%, 1 -20wt%, 1-15wt%, 1-10wt%, 1-8wt%, 1-5wt%, 1-2wt%, 1.5-30wt%, 1.5-25wt%, 1.5-20wt%, 1. 5-15wt%, 1.5-10wt%, 1.5-8wt%, 1.5-5wt%, 2-30wt%, 2-25wt%, 2-20wt%, 2-15wt%, 2-10wt%, 2 %, 3-10wt%, 3-8wt%, 3-5wt%, 5-30wt%, 5-25wt%, 5-20wt%, 5-15wt%, 5-10wt%, 5-8wt%, 10-30wt%, 10-25wt%, 10-20wt%, 10-15wt% and combinations thereof. In certain embodiments, the composition has no RC or substantially no RC.

[0190] In some embodiments, the amount of RD included in the one or more SGs in the composition is 0-30wt%, 0-25wt%, 0-20wt%, 0-15wt%, 0-10wt%, 0-8wt%, 0-5wt%, 0-2wt%, 0-1wt%, 0-0.5wt%, 0.1-30wt%, 0.1-25wt%, 0.1-20wt%, 0.1-15wt%, 0.1-10wt%. t%, 0.1-8wt%, 0.1-5wt%, 0.1-2wt%, 0.1-1wt%, 0.1-0.5wt%, 0.5-30wt%, 0.5-25wt%, 0.5-20 wt%, 0.5-15wt%, 0.5-10wt%, 0.5-8wt%, 0.5-5wt%, 0.5-2wt%, 0.5-1wt%, 1-30wt%, 1-25wt%, 1 -20wt%, 1-15wt%, 1-10wt%, 1-8wt%, 1-5wt%, 1-2wt%, 1.5-30wt%, 1.5-25wt%, 1.5-20wt%, 1. 5-15wt%, 1.5-10wt%, 1.5-8wt%, 1.5-5wt%, 2-30wt%, 2-25wt%, 2-20wt%, 2-15wt%, 2-10wt%, 2 %, 3-10wt%, 3-8wt%, 3-5wt%, 5-30wt%, 5-25wt%, 5-20wt%, 5-15wt%, 5-10wt%, 5-8wt%, 10-30wt%, 10-25wt%, 10-20wt%, 10-15wt% and combinations thereof. In certain embodiments, the composition has no RD or substantially no RD.

[0191] In some embodiments, the amount of RE included in the one or more SGs in the composition is 0-10wt%, 0-8wt%, 0-5wt%, 0-2wt%, 0-1wt%, 0-0.5wt%, 0.1-10wt%, 0.1-8wt%, 0.1-5wt%, 0.1-2wt%, 0.1-1wt%, 0.1-0.5wt%, 0.5-10wt%, 0.5-8wt%. %, 0.5-5wt%, 0.5-2wt%, 0.5-1wt%, 1-10wt%, 1-8wt%, 1-5wt%, 1-2wt%, 1.5-10wt%, 1.5-8wt%, 1.5-5wt%, 2-10wt%, 2-8wt%, 2-5wt%, 3-10wt%, 3-8wt%, 3-5wt%, 5-10wt%, 5-8wt% and combinations thereof. In certain embodiments, the composition has no RE or substantially no RE.

[0192] In some embodiments, the amount of RF included in the one or more SGs in the composition is 0-20wt%, 0-15wt%, 0-10wt%, 0-8wt%, 0-5wt%, 0-2wt%, 0-1wt%, 0-0.5wt%, 0.1-20wt%, 0.1-15wt%, 0.1-10wt%, 0.1-8wt%, 0.1-5wt%, 0.1-2wt%, 0.1-1wt%, 0.1-0.5wt%, 0.5-20wt%, 0.5-15wt%, 0.5-10wt%, 0.5-8wt%, 0.5-5wt%, 0.5-2wt%, 0.5 %, 3-20wt%, 3-15wt%, 3-10wt%, 3-8wt%, 3-5wt%, 5-20wt%, 5-15wt%, 5-10wt%, 5-8wt%, 10-20wt%, 10-15wt% and combinations thereof. In certain embodiments, the composition is free of RF or substantially free of RF.

[0193] In some embodiments, the amount of RM included in the one or more SGs in the composition is 0-30wt%, 0-25wt%, 0-20wt%, 0-15wt%, 0-10wt%, 0-8wt%, 0-5wt%, 0-2wt%, 0-1wt%, 0-0.5wt%, 0.1-30wt%, 0.1-25wt%, 0.1-20wt%, 0.1-15wt%, 0.1-10wt%. t%, 0.1-8wt%, 0.1-5wt%, 0.1-2wt%, 0.1-1wt%, 0.1-0.5wt%, 0.5-30wt%, 0.5-25wt%, 0.5-20 wt%, 0.5-15wt%, 0.5-10wt%, 0.5-8wt%, 0.5-5wt%, 0.5-2wt%, 0.5-1wt%, 1-30wt%, 1-25wt%, 1 -20wt%, 1-15wt%, 1-10wt%, 1-8wt%, 1-5wt%, 1-2wt%, 1.5-30wt%, 1.5-25wt%, 1.5-20wt%, 1. 5-15wt%, 1.5-10wt%, 1.5-8wt%, 1.5-5wt%, 2-30wt%, 2-25wt%, 2-20wt%, 2-15wt%, 2-10wt%, 2 %, 3-10wt%, 3-8wt%, 3-5wt%, 5-30wt%, 5-25wt%, 5-20wt%, 5-15wt%, 5-10wt%, 5-8wt%, 10-30wt%, 10-25wt%, 10-20wt%, 10-15wt% and combinations thereof. In certain embodiments, the composition has no RM or substantially no RM.

[0194] In some embodiments, the amount of RN included in one or more SGs in the composition is 0-10wt%, 0-8wt%, 0-5wt%, 0-2wt%, 0-1wt%, 0-0.5wt%, 0.1-10wt%, 0.1-8wt%, 0.1-5wt%, 0.1-2wt%, 0.1-1wt%, 0.1-0.5wt%, 0.5-10wt%, 0.5-8wt%. %, 0.5-5wt%, 0.5-2wt%, 0.5-1wt%, 1-10wt%, 1-8wt%, 1-5wt%, 1-2wt%, 1.5-10wt%, 1.5-8wt%, 1.5-5wt%, 2-10wt%, 2-8wt%, 2-5wt%, 3-10wt%, 3-8wt%, 3-5wt%, 5-10wt%, 5-8wt% and combinations thereof. In certain embodiments, the composition has no RN or substantially no RN.

[0195] In some embodiments, the amount of RO included in the one or more SGs in the composition is 0-10wt%, 0-8wt%, 0-5wt%, 0-2wt%, 0-1wt%, 0-0.5wt%, 0.1-10wt%, 0.1-8wt%, 0.1-5wt%, 0.1-2wt%, 0.1-1wt%, 0.1-0.5wt%, 0.5-10wt%, 0.5-8wt%. %, 0.5-5wt%, 0.5-2wt%, 0.5-1wt%, 1-10wt%, 1-8wt%, 1-5wt%, 1-2wt%, 1.5-10wt%, 1.5-8wt%, 1.5-5wt%, 2-10wt%, 2-8wt%, 2-5wt%, 3-10wt%, 3-8wt%, 3-5wt%, 5-10wt%, 5-8wt% and combinations thereof. In certain embodiments, the composition is free of RO or substantially free of RO.

[0196] In some embodiments, the one or more SGs in the composition include steviol glycosides in an amount of 5-80wt%, 5-70%, 5-60wt%, 5-55wt%, 5-50wt%, 5-45wt%, 5-40wt%, 5-35wt%, 5-30wt%, 5-25wt%, 5-20wt%, 5-15wt%, 5-10wt%, 5-8wt%, 10-80wt%, 10-70%, 10-60wt%, 10-55wt%. t%, 10-50wt%, 10-45wt%, 10-40wt%, 10-35wt%, 10-30wt%, 10-25wt%, 10-20wt%, 10-15wt%, 15-80wt%, 15 -70%, 15-60wt%, 15-55wt%, 15-50wt%, 15-45wt%, 15-40wt%, 15-35wt%, 15-30wt%, 15-25wt%, 15-20wt%, 20-80wt%, 20-70%, 20-60wt%, 20-55wt%, 20-50wt%, 20-45wt%, 20-40wt%, 20-35wt%, 20-30wt%, 20-25w t%, 25-80wt%, 25-70%, 25-60wt%, 25-55wt%, 25-50wt%, 25-45wt%, 25-40wt%, 25-35wt%, 25-30wt%, 30-8 0wt%, 30-70%, 30-60wt%, 30-55wt%, 30-50wt%, 30-45wt%, 30-40wt%, 30-35wt%, 40-80wt%, 40-70%, 40-60wt%, 40-55wt%, 40-50wt%, 40-45wt%, 50-80wt%, 50-70%, 50-60wt%, 50-55wt%, 60-80wt%, 60-70% and combinations thereof.

[0197] In some embodiments, the one or more SGs in the composition include the relevant SG#2 in an amount of 0-99wt%, 0-30wt%, 0-25wt%, 0-20wt%, 0-15wt%, 0-10wt%, 0-8wt%, 0-5wt%, 0-2wt%, 0-1wt%, 0-0.5wt%, 0.1-30wt%, 0.1-25wt%, 0.1-20wt%, 0.1-15wt%, 0.1-10wt%, 0.1-8wt%, 0.1-5wt%, 0.1-2wt%, 0.1-1wt%, 0.1-0.5wt%, 0.5-30wt%, 0.5-25wt%, 0.5-20wt%, 0.5-15wt%, 0.5-10wt%, 0.5-8wt%, 0.5-5wt%, 0. 5-2wt%, 0.5-1wt%, 1-30wt%, 1-25wt%, 1-20wt%, 1-15wt%, 1-10wt%, 1-8wt%, 1-5wt%, 1 -2wt%, 1.5-30wt%, 1.5-25wt%, 1.5-20wt%, 1.5-15wt%, 1.5-10wt%, 1.5-8wt%, 1.5-5wt %, 5-30wt%, 5-25wt%, 5-20wt%, 5-15wt%, 5-10wt%, 5-8wt%, 10-30wt%, 10-25wt%, 10-20wt%, 10-15wt%, 15-30wt%, 15-25wt%, 15-20wt%, 20-30wt%, 20-25wt% or 25-30wt% and combinations thereof. In certain embodiments, the composition has no associated SG#2 or substantially no associated SG#2.

[0198] In some embodiments, the one or more SGs in the composition include the relevant SG#5 in an amount of 0-99wt%, 0-30wt%, 0-25wt%, 0-20wt%, 0-15wt%, 0-10wt%, 0-8wt%, 0-5wt%, 0-2wt%, 0-1wt%, 0-0.5wt%, 0.1-30wt%, 0.1-25wt%, 0.1-20wt%, 0.1-15wt%, 0.1-10wt%, 0.1-8wt%, 0.1-5wt%, 0.1-2wt%, 0.1-1wt%, 0.1-0.5wt%, 0.5-30wt%, 0.5-25wt%, 0.5-20wt%, 0.5-15wt%, 0.5-10wt%, 0.5-8wt%, 0.5-5wt%, 0. 5-2wt%, 0.5-1wt%, 1-30wt%, 1-25wt%, 1-20wt%, 1-15wt%, 1-10wt%, 1-8wt%, 1-5wt%, 1 -2wt%, 1.5-30wt%, 1.5-25wt%, 1.5-20wt%, 1.5-15wt%, 1.5-10wt%, 1.5-8wt%, 1.5-5wt %, 5-30wt%, 5-25wt%, 5-20wt%, 5-15wt%, 5-10wt%, 5-8wt%, 10-30wt%, 10-25wt%, 10-20wt%, 10-15wt%, 15-30wt%, 15-25wt%, 15-20wt%, 20-30wt%, 20-25wt% or 25-30wt% and combinations thereof. In certain embodiments, the composition has no associated SG#5 or substantially no associated SG#5.

[0199] In some embodiments, the one or more SGs in the composition comprise RU2 in an amount of 0-99 wt%, 0-30 wt%, 0-25 wt%, 0-20 wt%, 0-15 wt%, 0-10 wt%, 0-8 wt%, 0-5 wt%, 0-2 wt%, 0-1 wt%, 0-0.5 wt%, 0.1-30 wt%, 0.1-25 wt%, 0.1-20 wt%, 0.1-15 wt%, 0.1-10 wt%, 0.1-8 wt%, 0.1-5 wt%, 0.1-2 wt%, 0.1-1 wt%, 0.1-0.5 wt%, 0.5-30 wt%, 0.5-25 wt%, 0.5-20 wt%, 0.5-15 wt%, 0.5-10 wt%, 0.5-8 wt%, 0.5-5 wt%, 0.5- 2wt%, 0.5-1wt%, 1-30wt%, 1-25wt%, 1-20wt%, 1-15wt%, 1-10wt%, 1-8wt%, 1-5wt%, 1-2 wt%, 1.5-30wt%, 1.5-25wt%, 1.5-20wt%, 1.5-15wt%, 1.5-10wt%, 1.5-8wt%, 1.5-5wt% %, 5-30wt%, 5-25wt%, 5-20wt%, 5-15wt%, 5-10wt%, 5-8wt%, 10-30wt%, 10-25wt%, 10-20wt%, 10-15wt%, 15-30wt%, 15-25wt%, 15-20wt%, 20-30wt%, 20-25wt% or 25-30wt% and combinations thereof. In certain embodiments, the composition has no RU2 or substantially no RU2.

[0200] In some embodiments, the amount of RT included in the one or more SGs in the composition is 0-99wt%, 0-30wt%, 0-25wt%, 0-20wt%, 0-15wt%, 0-10wt%, 0-8wt%, 0-5wt%, 0-2wt%, 0-1wt%, 0-0.5wt%, 0.1-30wt%, 0.1-25wt%, 0.1-20wt%, 0.1-15wt%, 0.1-10wt%, 0.1-8wt%, 0.1-5wt%, 0.1-2wt%, 0.1-1wt%, 0.1-0.5wt%, 0.5-30wt%, 0.5-25wt%, 0.5-20wt%, 0.5-15wt%, 0.5-10wt%, 0.5-8wt%, 0.5-5wt%, 0.5- 2wt%, 0.5-1wt%, 1-30wt%, 1-25wt%, 1-20wt%, 1-15wt%, 1-10wt%, 1-8wt%, 1-5wt%, 1-2 wt%, 1.5-30wt%, 1.5-25wt%, 1.5-20wt%, 1.5-15wt%, 1.5-10wt%, 1.5-8wt%, 1.5-5wt% %, 5-20wt%, 5-15wt%, 5-10wt%, 5-8wt%, 10-30wt%, 10-25wt%, 10-20wt%, 10-15wt%, 15-30wt%, 15-25wt%, 15-20wt%, 20-30wt%, 20-25wt% or 25-30wt% and combinations thereof. In certain embodiments, the composition has no RT or substantially no RT.

[0201] In some embodiments, the amount of one or more SGs in the composition comprising RW is 0-99wt%, 0-30wt%, 0-25wt%, 0-20wt%, 0-15wt%, 0-10wt%, 0-8wt%, 0-5wt%, 0-2wt%, 0-1wt%, 0-0.5wt%, 0.1-30wt%, 0.1-25wt%, 0.1-20wt%, 0.1-15wt%, 0.1-10wt%, 0.1-8wt%, 0.1-5wt%, 0.1-2wt%, 0.1-1wt%, 0.1-0.5wt%, 0.5-30wt%, 0.5-25wt%, 0.5-20wt%, 0.5-15wt%, 0.5-10wt%, 0.5-8wt%, 0.5-5wt%, 0.5- 2wt%, 0.5-1wt%, 1-30wt%, 1-25wt%, 1-20wt%, 1-15wt%, 1-10wt%, 1-8wt%, 1-5wt%, 1-2 wt%, 1.5-30wt%, 1.5-25wt%, 1.5-20wt%, 1.5-15wt%, 1.5-10wt%, 1.5-8wt%, 1.5-5wt% %, 5-20wt%, 5-15wt%, 5-10wt%, 5-8wt%, 10-30wt%, 10-25wt%, 10-20wt%, 10-15wt%, 15-30wt%, 15-25wt%, 15-20wt%, 20-30wt%, 20-25wt% or 25-30wt% and combinations thereof. In certain embodiments, the composition has no RW or substantially no RW.

[0202] In some embodiments, the amount of RW2 included in the composition of one or more SG is 0-99wt%, 0-30wt%, 0-25wt%, 0-20wt%, 0-15wt%, 0-10wt%, 0-8wt%, 0-5wt%, 0-2wt%, 0-1wt%, 0-0.5wt%, 0.1-30wt%, 0.1-25wt%, 0.1-20wt%, 0.1-15wt%, 0.1-10wt%, 0.1-8wt%, 0.1-5wt%, 0.1-2wt%, 0.1-1wt%, 0.1-0.5wt%, 0.5-30wt%, 0.5-25wt%, 0.5-20wt%, 0.5-15wt%, 0.5-10wt%, 0.5-8wt%, 0.5-5wt%, 0.5- 2wt%, 0.5-1wt%, 1-30wt%, 1-25wt%, 1-20wt%, 1-15wt%, 1-10wt%, 1-8wt%, 1-5wt%, 1-2 wt%,1.5-30wt%,1.5-25wt%,1.5-20wt%,1.5-15wt%,1.5-10wt%,1.5-8wt%,1.5-5wt% %, 5-30wt%, 5-25wt%, 5-20wt%, 5-15wt%, 5-10wt%, 5-8wt%, 10-30wt%, 10-25wt%, 10-20wt%, 10-15wt%, 15-30wt%, 15-25wt%, 15-20wt%, 20-30wt%, 20-25wt% or 25-30wt% and combinations thereof. In certain embodiments, the composition is free of RW2 or substantially free of RW2.

[0203] In some embodiments, the amount of RW3 included in the one or more SGs in the composition is 0-99wt%, 0-30wt%, 0-25wt%, 0-20wt%, 0-15wt%, 0-10wt%, 0-8wt%, 0-5wt%, 0-2wt%, 0-1wt%, 0-0.5wt%, 0.1-30wt%, 0.1-25wt%, 0.1-20wt%, 0.1-15wt%, 0.1-10wt%, 0.1-8wt%, 0.1-5wt%, 0.1-2wt%, 0.1-1wt%, 0.1-0.5wt%, 0.5-30wt%, 0.5-25wt%, 0.5-20wt%, 0.5-15wt%, 0.5-10wt%, 0.5-8wt%, 0.5-5wt%, 0.5- 2wt%, 0.5-1wt%, 1-30wt%, 1-25wt%, 1-20wt%, 1-15wt%, 1-10wt%, 1-8wt%, 1-5wt%, 1-2 wt%, 1.5-30wt%, 1.5-25wt%, 1.5-20wt%, 1.5-15wt%, 1.5-10wt%, 1.5-8wt%, 1.5-5wt% %, 5-20wt%, 5-15wt%, 5-10wt%, 5-8wt%, 10-30wt%, 10-25wt%, 10-20wt%, 10-15wt%, 15-30wt%, 15-25wt%, 15-20wt%, 20-30wt%, 20-25wt% or 25-30wt% and combinations thereof. In certain embodiments, the composition has no RW3 or substantially no RW3.

[0204] In some embodiments, the amount of RU included in the one or more SGs in the composition is 0-99wt%, 0-30wt%, 0-25wt%, 0-20wt%, 0-15wt%, 0-10wt%, 0-8wt%, 0-5wt%, 0-2wt%, 0-1wt%, 0-0.5wt%, 0.1-30wt%, 0.1-25wt%, 0.1-20wt%, 0.1-15wt%, 0.1-10wt%, 0.1-8wt%, 0.1-5wt%, 0.1-2wt%, 0.1-1wt%, 0.1-0.5wt%, 0.5-30wt%, 0.5-25wt%, 0.5-20wt%, 0.5-15wt%, 0.5-10wt%, 0.5-8wt%, 0.5-5wt%, 0.5- 2wt%, 0.5-1wt%, 1-30wt%, 1-25wt%, 1-20wt%, 1-15wt%, 1-10wt%, 1-8wt%, 1-5wt%, 1-2 wt%, 1.5-30wt%, 1.5-25wt%, 1.5-20wt%, 1.5-15wt%, 1.5-10wt%, 1.5-8wt%, 1.5-5wt% %, 5-20wt%, 5-15wt%, 5-10wt%, 5-8wt%, 10-30wt%, 10-25wt%, 10-20wt%, 10-15wt%, 15-30wt%, 15-25wt%, 15-20wt%, 20-30wt%, 20-25wt% or 25-30wt% and combinations thereof. In certain embodiments, the composition has no RU or substantially no RU.

[0205] In some embodiments, the one or more SGs in the composition include SG-12 in an amount of 0-99wt%, 0-30wt%, 0-25wt%, 0-20wt%, 0-15wt%, 0-10wt%, 0-8wt%, 0-5wt%, 0-2wt%, 0-1wt%, 0-0.5wt%, 0.1-30wt%, 0.1-25wt%, 0.1-20wt%, 0.1-15wt%, 0.1-10wt%, 0.1-8wt%, 0.1-5wt%, 0.1-2wt%, 0.1-1wt%, 0.1-0.5wt%, 0.5-30wt%, 0.5-25wt%, 0.5-20wt%, 0.5-15wt%, 0.5-10wt%, 0.5-8wt%, 0.5-5wt%, 0.5 -2wt%, 0.5-1wt%, 1-30wt%, 1-25wt%, 1-20wt%, 1-15wt%, 1-10wt%, 1-8wt%, 1-5wt%, 1- 2wt%, 1.5-30wt%, 1.5-25wt%, 1.5-20wt%, 1.5-15wt%, 1.5-10wt%, 1.5-8wt%, 1.5-5wt %, 5-30wt%, 5-25wt%, 5-20wt%, 5-15wt%, 5-10wt%, 5-8wt%, 10-30wt%, 10-25wt%, 10-20wt%, 10-15wt%, 15-30wt%, 15-25wt%, 15-20wt%, 20-30wt%, 20-25wt% or 25-30wt% and combinations thereof. In certain embodiments, the composition is free of SG-12 or substantially free of SG-12.

[0206] In some embodiments, the one or more SGs in the composition include RH in an amount of 0-99wt%, 0-30wt%, 0-25wt%, 0-20wt%, 0-15wt%, 0-10wt%, 0-8wt%, 0-5wt%, 0-2wt%, 0-1wt%, 0-0.5wt%, 0.1-30wt%, 0.1-25wt%, 0.1-20wt%, 0.1-15wt%, 0.1-10wt%, 0.1-8wt%, 0.1-5wt%, 0.1-2wt%, 0.1-1wt%, 0.1-0.5wt%, 0.5-30wt%, 0.5-25wt%, 0.5-20wt%, 0.5-15wt%, 0.5-10wt%, 0.5-8wt%, 0.5-5wt%, 0.5- 2wt%, 0.5-1wt%, 1-30wt%, 1-25wt%, 1-20wt%, 1-15wt%, 1-10wt%, 1-8wt%, 1-5wt%, 1-2 wt%, 1.5-30wt%, 1.5-25wt%, 1.5-20wt%, 1.5-15wt%, 1.5-10wt%, 1.5-8wt%, 1.5-5wt% %, 5-20wt%, 5-15wt%, 5-10wt%, 5-8wt%, 10-30wt%, 10-25wt%, 10-20wt%, 10-15wt%, 15-30wt%, 15-25wt%, 15-20wt%, 20-30wt%, 20-25wt% or 25-30wt% and combinations thereof. In certain embodiments, the composition has no RH or substantially no RH.

[0207] In some embodiments, the amount of one or more SGs in the composition comprising RJ is 0-99wt%, 0-30wt%, 0-25wt%, 0-20wt%, 0-15wt%, 0-10wt%, 0-8wt%, 0-5wt%, 0-2wt%, 0-1wt%, 0-0.5wt%, 0.1-30wt%, 0.1-25wt%, 0.1-20wt%, 0.1-15wt%, 0.1-10wt%, 0.1-8wt%, 0.1-5wt%, 0.1-2wt%, 0.1-1wt%, 0.1-0.5wt%, 0.5-30wt%, 0.5-25wt%, 0.5-20wt%, 0.5-15wt%, 0.5-10wt%, 0.5-8wt%, 0.5-5wt%, 0.5- 2wt%, 0.5-1wt%, 1-30wt%, 1-25wt%, 1-20wt%, 1-15wt%, 1-10wt%, 1-8wt%, 1-5wt%, 1-2 wt%,1.5-30wt%,1.5-25wt%,1.5-20wt%,1.5-15wt%,1.5-10wt%,1.5-8wt%,1.5-5wt% %, 5-30wt%, 5-25wt%, 5-20wt%, 5-15wt%, 5-10wt%, 5-8wt%, 10-30wt%, 10-25wt%, 10-20wt%, 10-15wt%, 15-30wt%, 15-25wt%, 15-20wt%, 20-30wt%, 20-25wt% or 25-30wt% and combinations thereof. In certain embodiments, the composition is free of RJ or substantially free of RJ.

[0208] In some embodiments, the amount of RK included in the one or more SGs in the composition is 0-99wt%, 0-30wt%, 0-25wt%, 0-20wt%, 0-15wt%, 0-10wt%, 0-8wt%, 0-5wt%, 0-2wt%, 0-1wt%, 0-0.5wt%, 0.1-30wt%, 0.1-25wt%, 0.1-20wt%, 0.1-15wt%, 0.1-10wt%, 0.1-8wt%, 0.1-5wt%, 0.1-2wt%, 0.1-1wt%, 0.1-0.5wt%, 0.5-30wt%, 0.5-25wt%, 0.5-20wt%, 0.5-15wt%, 0.5-10wt%, 0.5-8wt%, 0.5-5wt%, 0.5- 2wt%, 0.5-1wt%, 1-30wt%, 1-25wt%, 1-20wt%, 1-15wt%, 1-10wt%, 1-8wt%, 1-5wt%, 1-2 wt%, 1.5-30wt%, 1.5-25wt%, 1.5-20wt%, 1.5-15wt%, 1.5-10wt%, 1.5-8wt%, 1.5-5wt% %, 5-20wt%, 5-15wt%, 5-10wt%, 5-8wt%, 10-30wt%, 10-25wt%, 10-20wt%, 10-15wt%, 15-30wt%, 15-25wt%, 15-20wt%, 20-30wt%, 20-25wt% or 25-30wt% and combinations thereof. In certain embodiments, the composition has no RK or substantially no RK.

[0209] In some embodiments, the amount of RK2 included in the one or more SGs in the composition is 0-99wt%, 0-30wt%, 0-25wt%, 0-20wt%, 0-15wt%, 0-10wt%, 0-8wt%, 0-5wt%, 0-2wt%, 0-1wt%, 0-0.5wt%, 0.1-30wt%, 0.1-25wt%, 0.1-20wt%, 0.1-15wt%, 0.1-10wt%, 0.1-8wt%, 0.1-5wt%, 0.1-2wt%, 0.1-1wt%, 0.1-0.5wt%, 0.5-30wt%, 0.5-25wt%, 0.5-20wt%, 0.5-15wt%, 0.5-10wt%, 0.5-8wt%, 0.5-5wt%, 0.5- 2wt%, 0.5-1wt%, 1-30wt%, 1-25wt%, 1-20wt%, 1-15wt%, 1-10wt%, 1-8wt%, 1-5wt%, 1-2 wt%, 1.5-30wt%, 1.5-25wt%, 1.5-20wt%, 1.5-15wt%, 1.5-10wt%, 1.5-8wt%, 1.5-5wt% %, 5-20wt%, 5-15wt%, 5-10wt%, 5-8wt%, 10-30wt%, 10-25wt%, 10-20wt%, 10-15wt%, 15-30wt%, 15-25wt%, 15-20wt%, 20-30wt%, 20-25wt% or 25-30wt% and combinations thereof. In certain embodiments, the composition is free of RK2 or substantially free of RK2.

[0210] In some embodiments, the one or more SGs in the composition include SG-Unk4 in an amount of 0-99wt%, 0-30wt%, 0-25wt%, 0-20wt%, 0-15wt%, 0-10wt%, 0-8wt%, 0-5wt%, 0-2wt%, 0-1wt%, 0-0.5wt%, 0.1-30wt%, 0.1-25wt%, 0.1-20wt%, 0.1-15wt%, 0.1-10wt%, 0.1-8wt%, 0.1-5wt%, 0.1-2wt%, 0.1-1wt%, 0.1-0.5wt%, 0.5-30wt%, 0.5-25wt%, 0.5-20wt%, 0.5-15wt%, 0.5-10wt%, 0.5-8wt%, 0.5-5wt%, 0. 5-2wt%, 0.5-1wt%, 1-30wt%, 1-25wt%, 1-20wt%, 1-15wt%, 1-10wt%, 1-8wt%, 1-5wt%, 1 -2wt%, 1.5-30wt%, 1.5-25wt%, 1.5-20wt%, 1.5-15wt%, 1.5-10wt%, 1.5-8wt%, 1.5-5wt %, 5-30wt%, 5-25wt%, 5-20wt%, 5-15wt%, 5-10wt%, 5-8wt%, 10-30wt%, 10-25wt%, 10-20wt%, 10-15wt%, 15-30wt%, 15-25wt%, 15-20wt%, 20-30wt%, 20-25wt% or 25-30wt% and combinations thereof. In certain embodiments, the composition is free of SG-Unk4 or substantially free of SG-Unk4.

[0211] In some embodiments, the one or more SGs in the composition include SG-Unk5 in an amount of 0-99wt%, 0-30wt%, 0-25wt%, 0-20wt%, 0-15wt%, 0-10wt%, 0-8wt%, 0-5wt%, 0-2wt%, 0-1wt%, 0-0.5wt%, 0.1-30wt%, 0.1-25wt%, 0.1-20wt%, 0.1-15wt%, 0.1-10wt%, 0.1-8wt%, 0.1-5wt%, 0.1-2wt%, 0.1-1wt%, 0.1-0.5wt%, 0.5-30wt%, 0.5-25wt%, 0.5-20wt%, 0.5-15wt%, 0.5-10wt%, 0.5-8wt%, 0.5-5wt%, 0. 5-2wt%, 0.5-1wt%, 1-30wt%, 1-25wt%, 1-20wt%, 1-15wt%, 1-10wt%, 1-8wt%, 1-5wt%, 1 -2wt%, 1.5-30wt%, 1.5-25wt%, 1.5-20wt%, 1.5-15wt%, 1.5-10wt%, 1.5-8wt%, 1.5-5wt %, 5-30wt%, 5-25wt%, 5-20wt%, 5-15wt%, 5-10wt%, 5-8wt%, 10-30wt%, 10-25wt%, 10-20wt%, 10-15wt%, 15-30wt%, 15-25wt%, 15-20wt%, 20-30wt%, 20-25wt% or 25-30wt% and combinations thereof. In certain embodiments, the composition is free of SG-Unk5 or substantially free of SG-Unk5.

[0212] In some embodiments, the amount of RI included in the one or more SGs in the composition is 0-99wt%, 0-30wt%, 0-25wt%, 0-20wt%, 0-15wt%, 0-10wt%, 0-8wt%, 0-5wt%, 0-2wt%, 0-1wt%, 0-0.5wt%, 0.1-30wt%, 0.1-25wt%, 0.1-20wt%, 0.1-15wt%, 0.1-10wt%, 0.1-8wt%, 0.1-5wt%, 0.1-2wt%, 0.1-1wt%, 0.1-0.5wt%, 0.5-30wt%, 0.5-25wt%, 0.5-20wt%, 0.5-15wt%, 0.5-10wt%, 0.5-8wt%, 0.5-5wt%, 0.5- 2wt%, 0.5-1wt%, 1-30wt%, 1-25wt%, 1-20wt%, 1-15wt%, 1-10wt%, 1-8wt%, 1-5wt%, 1-2 wt%, 1.5-30wt%, 1.5-25wt%, 1.5-20wt%, 1.5-15wt%, 1.5-10wt%, 1.5-8wt%, 1.5-5wt% %, 5-20wt%, 5-15wt%, 5-10wt%, 5-8wt%, 10-30wt%, 10-25wt%, 10-20wt%, 10-15wt%, 15-30wt%, 15-25wt%, 15-20wt%, 20-30wt%, 20-25wt% or 25-30wt% and combinations thereof. In certain embodiments, the composition has no RI or substantially no RI.

[0213] In some embodiments, the amount of RL included in the one or more SGs in the composition is 0-99wt%, 0-30wt%, 0-25wt%, 0-20wt%, 0-15wt%, 0-10wt%, 0-8wt%, 0-5wt%, 0-2wt%, 0-1wt%, 0-0.5wt%, 0.1-30wt%, 0.1-25wt%, 0.1-20wt%, 0.1-15wt%, 0.1-10wt%, 0.1-8wt%, 0.1-5wt%, 0.1-2wt%, 0.1-1wt%, 0.1-0.5wt%, 0.5-30wt%, 0.5-25wt%, 0.5-20wt%, 0.5-15wt%, 0.5-10wt%, 0.5-8wt%, 0.5-5wt%, 0.5- 2wt%, 0.5-1wt%, 1-30wt%, 1-25wt%, 1-20wt%, 1-15wt%, 1-10wt%, 1-8wt%, 1-5wt%, 1-2 wt%, 1.5-30wt%, 1.5-25wt%, 1.5-20wt%, 1.5-15wt%, 1.5-10wt%, 1.5-8wt%, 1.5-5wt% %, 5-20wt%, 5-15wt%, 5-10wt%, 5-8wt%, 10-30wt%, 10-25wt%, 10-20wt%, 10-15wt%, 15-30wt%, 15-25wt%, 15-20wt%, 20-30wt%, 20-25wt% or 25-30wt% and combinations thereof. In certain embodiments, the composition has no RL or substantially no RL.

[0214] In some embodiments, the amount of RI3 included in the one or more SGs in the composition is 0-99wt%, 0-30wt%, 0-25wt%, 0-20wt%, 0-15wt%, 0-10wt%, 0-8wt%, 0-5wt%, 0-2wt%, 0-1wt%, 0-0.5wt%, 0.1-30wt%, 0.1-25wt%, 0.1-20wt%, 0.1-15wt%, 0.1-10wt%, 0.1-8wt%, 0.1-5wt%, 0.1-2wt%, 0.1-1wt%, 0.1-0.5wt%, 0.5-30wt%, 0.5-25wt%, 0.5-20wt%, 0.5-15wt%, 0.5-10wt%, 0.5-8wt%, 0.5-5wt%, 0.5- 2wt%, 0.5-1wt%, 1-30wt%, 1-25wt%, 1-20wt%, 1-15wt%, 1-10wt%, 1-8wt%, 1-5wt%, 1-2 wt%, 1.5-30wt%, 1.5-25wt%, 1.5-20wt%, 1.5-15wt%, 1.5-10wt%, 1.5-8wt%, 1.5-5wt% %, 5-20wt%, 5-15wt%, 5-10wt%, 5-8wt%, 10-30wt%, 10-25wt%, 10-20wt%, 10-15wt%, 15-30wt%, 15-25wt%, 15-20wt%, 20-30wt%, 20-25wt% or 25-30wt% and combinations thereof. In certain embodiments, the composition has no RI3 or substantially no RI3.

[0215] In some embodiments, the one or more SGs in the composition include SG-Unk6 in an amount of 0-99wt%, 0-30wt%, 0-25wt%, 0-20wt%, 0-15wt%, 0-10wt%, 0-8wt%, 0-5wt%, 0-2wt%, 0-1wt%, 0-0.5wt%, 0.1-30wt%, 0.1-25wt%, 0.1-20wt%, 0.1-15wt%, 0.1-10wt%, 0.1-8wt%, 0.1-5wt%, 0.1-2wt%, 0.1-1wt%, 0.1-0.5wt%, 0.5-30wt%, 0.5-25wt%, 0.5-20wt%, 0.5-15wt%, 0.5-10wt%, 0.5-8wt%, 0.5-5wt%, 0. 5-2wt%, 0.5-1wt%, 1-30wt%, 1-25wt%, 1-20wt%, 1-15wt%, 1-10wt%, 1-8wt%, 1-5wt%, 1 -2wt%, 1.5-30wt%, 1.5-25wt%, 1.5-20wt%, 1.5-15wt%, 1.5-10wt%, 1.5-8wt%, 1.5-5wt %, 5-30wt%, 5-25wt%, 5-20wt%, 5-15wt%, 5-10wt%, 5-8wt%, 10-30wt%, 10-25wt%, 10-20wt%, 10-15wt%, 15-30wt%, 15-25wt%, 15-20wt%, 20-30wt%, 20-25wt% or 25-30wt% and combinations thereof. In certain embodiments, the composition is free of SG-Unk6 or substantially free of SG-Unk6.

[0216] In some embodiments, the amount of one or more SGs in the composition comprising RQ is 0-99wt%, 0-30wt%, 0-25wt%, 0-20wt%, 0-15wt%, 0-10wt%, 0-8wt%, 0-5wt%, 0-2wt%, 0-1wt%, 0-0.5wt%, 0.1-30wt%, 0.1-25wt%, 0.1-20wt%, 0.1-15wt%, 0.1-10wt%, 0.1-8wt%, 0.1-5wt%, 0.1-2wt%, 0.1-1wt%, 0.1-0.5wt%, 0.5-30wt%, 0.5-25wt%, 0.5-20wt%, 0.5-15wt%, 0.5-10wt%, 0.5-8wt%, 0.5-5wt%, 0.5- 2wt%, 0.5-1wt%, 1-30wt%, 1-25wt%, 1-20wt%, 1-15wt%, 1-10wt%, 1-8wt%, 1-5wt%, 1-2 wt%, 1.5-30wt%, 1.5-25wt%, 1.5-20wt%, 1.5-15wt%, 1.5-10wt%, 1.5-8wt%, 1.5-5wt% %, 5-20wt%, 5-15wt%, 5-10wt%, 5-8wt%, 10-30wt%, 10-25wt%, 10-20wt%, 10-15wt%, 15-30wt%, 15-25wt%, 15-20wt%, 20-30wt%, 20-25wt% or 25-30wt% and combinations thereof. In certain embodiments, the composition has no RQ or substantially no RQ.

[0217] In some embodiments, the amount of RQ2 included in the composition of one or more SG is 0-99wt%, 0-30wt%, 0-25wt%, 0-20wt%, 0-15wt%, 0-10wt%, 0-8wt%, 0-5wt%, 0-2wt%, 0-1wt%, 0-0.5wt%, 0.1-30wt%, 0.1-25wt%, 0.1-20wt%, 0.1-15wt%, 0.1-10wt%, 0.1-8wt%, 0.1-5wt%, 0.1-2wt%, 0.1-1wt%, 0.1-0.5wt%, 0.5-30wt%, 0.5-25wt%, 0.5-20wt%, 0.5-15wt%, 0.5-10wt%, 0.5-8wt%, 0.5-5wt%, 0.5- 2wt%, 0.5-1wt%, 1-30wt%, 1-25wt%, 1-20wt%, 1-15wt%, 1-10wt%, 1-8wt%, 1-5wt%, 1-2 wt%, 1.5-30wt%, 1.5-25wt%, 1.5-20wt%, 1.5-15wt%, 1.5-10wt%, 1.5-8wt%, 1.5-5wt% %, 5-20wt%, 5-15wt%, 5-10wt%, 5-8wt%, 10-30wt%, 10-25wt%, 10-20wt%, 10-15wt%, 15-30wt%, 15-25wt%, 15-20wt%, 20-30wt%, 20-25wt% or 25-30wt% and combinations thereof. In certain embodiments, the composition has no RQ2 or substantially no RQ2.

[0218] In some embodiments, the amount of RQ3 included in the one or more SGs in the composition is 0-99wt%, 0-30wt%, 0-25wt%, 0-20wt%, 0-15wt%, 0-10wt%, 0-8wt%, 0-5wt%, 0-2wt%, 0-1wt%, 0-0.5wt%, 0.1-30wt%, 0.1-25wt%, 0.1-20wt%, 0.1-15wt%, 0.1-10wt%, 0.1-8wt%, 0.1-5wt%, 0.1-2wt%, 0.1-1wt%, 0.1-0.5wt%, 0.5-30wt%, 0.5-25wt%, 0.5-20wt%, 0.5-15wt%, 0.5-10wt%, 0.5-8wt%, 0.5-5wt%, 0.5- 2wt%, 0.5-1wt%, 1-30wt%, 1-25wt%, 1-20wt%, 1-15wt%, 1-10wt%, 1-8wt%, 1-5wt%, 1-2 wt%, 1.5-30wt%, 1.5-25wt%, 1.5-20wt%, 1.5-15wt%, 1.5-10wt%, 1.5-8wt%, 1.5-5wt% %, 5-20wt%, 5-15wt%, 5-10wt%, 5-8wt%, 10-30wt%, 10-25wt%, 10-20wt%, 10-15wt%, 15-30wt%, 15-25wt%, 15-20wt%, 20-30wt%, 20-25wt% or 25-30wt% and combinations thereof. In certain embodiments, the composition has no RQ3 or substantially no RQ3.

[0219] In some embodiments, the one or more SGs in the composition include RT1 in an amount of 0-99wt%, 0-30wt%, 0-25wt%, 0-20wt%, 0-15wt%, 0-10wt%, 0-8wt%, 0-5wt%, 0-2wt%, 0-1wt%, 0-0.5wt%, 0.1-30wt%, 0.1-25wt%, 0.1-20wt%, 0.1-15wt%, 0.1-10wt%, 0.1-8wt%, 0.1-5wt%, 0.1-2wt%, 0.1-1wt%, 0.1-0.5wt%, 0.5-30wt%, 0.5-25wt%, 0.5-20wt%, 0.5-15wt%, 0.5-10wt%, 0.5-8wt%, 0.5-5wt%, 0.5- 2wt%, 0.5-1wt%, 1-30wt%, 1-25wt%, 1-20wt%, 1-15wt%, 1-10wt%, 1-8wt%, 1-5wt%, 1-2 wt%, 1.5-30wt%, 1.5-25wt%, 1.5-20wt%, 1.5-15wt%, 1.5-10wt%, 1.5-8wt%, 1.5-5wt% %, 5-20wt%, 5-15wt%, 5-10wt%, 5-8wt%, 10-30wt%, 10-25wt%, 10-20wt%, 10-15wt%, 15-30wt%, 15-25wt%, 15-20wt%, 20-30wt%, 20-25wt% or 25-30wt% and combinations thereof. In certain embodiments, the composition has no RT1 or substantially no RT1.

[0220] In some embodiments, the one or more SGs in the composition include the relevant SG#4 in an amount of 0-99wt%, 0-30wt%, 0-25wt%, 0-20wt%, 0-15wt%, 0-10wt%, 0-8wt%, 0-5wt%, 0-2wt%, 0-1wt%, 0-0.5wt%, 0.1-30wt%, 0.1-25wt%, 0.1-20wt%, 0.1-15wt%, 0.1-10wt%, 0.1-8wt%, 0.1-5wt%, 0.1-2wt%, 0.1-1wt%, 0.1-0.5wt%, 0.5-30wt%, 0.5-25wt%, 0.5-20wt%, 0.5-15wt%, 0.5-10wt%, 0.5-8wt%, 0.5-5wt%, 0. 5-2wt%, 0.5-1wt%, 1-30wt%, 1-25wt%, 1-20wt%, 1-15wt%, 1-10wt%, 1-8wt%, 1-5wt%, 1 -2wt%, 1.5-30wt%, 1.5-25wt%, 1.5-20wt%, 1.5-15wt%, 1.5-10wt%, 1.5-8wt%, 1.5-5wt %, 5-30wt%, 5-25wt%, 5-20wt%, 5-15wt%, 5-10wt%, 5-8wt%, 10-30wt%, 10-25wt%, 10-20wt%, 10-15wt%, 15-30wt%, 15-25wt%, 15-20wt%, 20-30wt%, 20-25wt% or 25-30wt% and combinations thereof. In certain embodiments, the composition has no associated SG#4 or substantially no associated SG#4.

[0221] In some embodiments, the amount of RV2 included in the one or more SGs in the composition is 0-99wt%, 0-30wt%, 0-25wt%, 0-20wt%, 0-15wt%, 0-10wt%, 0-8wt%, 0-5wt%, 0-2wt%, 0-1wt%, 0-0.5wt%, 0.1-30wt%, 0.1-25wt%, 0.1-20wt%, 0.1-15wt%, 0.1-10wt%, 0.1-8wt%, 0.1-5wt%, 0.1-2wt%, 0.1-1wt%, 0.1-0.5wt%, 0.5-30wt%, 0.5-25wt%, 0.5-20wt%, 0.5-15wt%, 0.5-10wt%, 0.5-8wt%, 0.5-5wt%, 0.5- 2wt%, 0.5-1wt%, 1-30wt%, 1-25wt%, 1-20wt%, 1-15wt%, 1-10wt%, 1-8wt%, 1-5wt%, 1-2 wt%, 1.5-30wt%, 1.5-25wt%, 1.5-20wt%, 1.5-15wt%, 1.5-10wt%, 1.5-8wt%, 1.5-5wt% %, 5-20wt%, 5-15wt%, 5-10wt%, 5-8wt%, 10-30wt%, 10-25wt%, 10-20wt%, 10-15wt%, 15-30wt%, 15-25wt%, 15-20wt%, 20-30wt%, 20-25wt% or 25-30wt% and combinations thereof. In certain embodiments, the composition has no RV2 or substantially no RV2.

[0222] In some embodiments, the amount of RV included in the one or more SGs in the composition is 0-99wt%, 0-30wt%, 0-25wt%, 0-20wt%, 0-15wt%, 0-10wt%, 0-8wt%, 0-5wt%, 0-2wt%, 0-1wt%, 0-0.5wt%, 0.1-30wt%, 0.1-25wt%, 0.1-20wt%, 0.1-15wt%, 0.1-10wt%, 0.1-8wt%, 0.1-5wt%, 0.1-2wt%, 0.1-1wt%, 0.1-0.5wt%, 0.5-30wt%, 0.5-25wt%, 0.5-20wt%, 0.5-15wt%, 0.5-10wt%, 0.5-8wt%, 0.5-5wt%, 0.5- 2wt%, 0.5-1wt%, 1-30wt%, 1-25wt%, 1-20wt%, 1-15wt%, 1-10wt%, 1-8wt%, 1-5wt%, 1-2 wt%, 1.5-30wt%, 1.5-25wt%, 1.5-20wt%, 1.5-15wt%, 1.5-10wt%, 1.5-8wt%, 1.5-5wt% %, 5-20wt%, 5-15wt%, 5-10wt%, 5-8wt%, 10-30wt%, 10-25wt%, 10-20wt%, 10-15wt%, 15-30wt%, 15-25wt%, 15-20wt%, 20-30wt%, 20-25wt% or 25-30wt% and combinations thereof. In certain embodiments, the composition has no RV or is substantially free of RV.

[0223] In some embodiments, the one or more SGs in the composition comprise RY in an amount of 0-99wt%, 0-30wt%, 0-25wt%, 0-20wt%, 0-15wt%, 0-10wt%, 0-8wt%, 0-5wt%, 0-2wt%, 0-1wt%, 0-0.5wt%, 0.1-30wt%, 0.1-25wt%, 0.1-20wt%, 0.1-15wt%, 0.1-10wt%, 0.1-8wt%, 0.1-5wt%, 0.1-2wt%, 0.1-1wt%, 0.1-0.5wt%, 0.5-30wt%, 0.5-25wt%, 0.5-20wt%, 0.5-15wt%, 0.5-10wt%, 0.5-8wt%, 0.5-5wt%, 0.5- 2wt%, 0.5-1wt%, 1-30wt%, 1-25wt%, 1-20wt%, 1-15wt%, 1-10wt%, 1-8wt%, 1-5wt%, 1-2 wt%, 1.5-30wt%, 1.5-25wt%, 1.5-20wt%, 1.5-15wt%, 1.5-10wt%, 1.5-8wt%, 1.5-5wt% %, 5-20wt%, 5-15wt%, 5-10wt%, 5-8wt%, 10-30wt%, 10-25wt%, 10-20wt%, 10-15wt%, 15-30wt%, 15-25wt%, 15-20wt%, 20-30wt%, 20-25wt% or 25-30wt% and combinations thereof. In certain embodiments, the composition is free of RY or substantially free of RY.

[0224] In some embodiments, the one or more SGs in the composition include 15α-OH The amount of RM is 0-99wt%, 0-30wt%, 0-25wt%, 0-20wt%, 0-15wt%, 0-10wt%, 0-8wt%, 0-5wt%, 0-2wt%, 0-1wt%, 0-0.5wt%, 0.1-30wt%, 0.1-25wt%, 0.1-20wt%, 0.1-15wt%, 0.1-10wt%, 0.1-8wt%, 0.1-5wt%, 0.1-2wt%, 0.1-1wt%, 0.1-0.5wt%, 0.5-30wt%, 0.5-25wt%, 0.5-20wt%, 0.5-15wt%, 0.5-10wt%, 0.5-8wt%, 0.5-5wt%, 0.5-2wt%, 0.5-1wt %, 1-30wt%, 1-25wt%, 1-20wt%, 1-15wt%, 1-10wt%, 1-8wt%, 1-5wt%, 1-2wt%, 1.5-30wt%, 1.5-25wt%, 1.5-20wt%, 1.5-15wt%, 1.5-10wt%, 1.5-8wt%, 1.5-5wt%, 5-30wt%, 5-25wt%, 5-20wt%, 5-15wt%, 5-10wt%, 5-8wt%, 10-30wt%, 10-25wt%, 10-20wt%, 10-15wt%, 15-30wt%, 15-25wt%, 15-20wt%, 20-30wt%, 20-25wt% or 25-30wt% and combinations thereof. In certain embodiments, the composition is free of 15a-OH RM or substantially free of 15a-OH RM.

[0225] In some embodiments, the amount of RO2 included in the one or more SGs in the composition is 0-99wt%, 0-30wt%, 0-25wt%, 0-20wt%, 0-15wt%, 0-10wt%, 0-8wt%, 0-5wt%, 0-2wt%, 0-1wt%, 0-0.5wt%, 0.1-30wt%, 0.1-25wt%, 0.1-20wt%, 0.1-15wt%, 0.1-10wt%, 0.1-8wt%, 0.1-5wt%, 0.1-2wt%, 0.1-1wt%, 0.1-0.5wt%, 0.5-30wt%, 0.5-25wt%, 0.5-20wt%, 0.5-15wt%, 0.5-10wt%, 0.5-8wt%, 0.5-5wt%, 0.5- 2wt%, 0.5-1wt%, 1-30wt%, 1-25wt%, 1-20wt%, 1-15wt%, 1-10wt%, 1-8wt%, 1-5wt%, 1-2 wt%, 1.5-30wt%, 1.5-25wt%, 1.5-20wt%, 1.5-15wt%, 1.5-10wt%, 1.5-8wt%, 1.5-5wt% %, 5-20wt%, 5-15wt%, 5-10wt%, 5-8wt%, 10-30wt%, 10-25wt%, 10-20wt%, 10-15wt%, 15-30wt%, 15-25wt%, 15-20wt%, 20-30wt%, 20-25wt% or 25-30wt% and combinations thereof. In certain embodiments, the composition has no RO2 or substantially no RO2.

[0226] In some embodiments, the SG composition comprises RA, RB, RC, RD, RE, RF, rubusoside, steviolbioside, steviol glycoside and dulcoside A, wherein the total SG content of these 10 SGs is about 65 wt % or more, 70 wt % or more, 75 wt % or more, 80 wt % or more, 85 wt % or more, 90 wt % or more, 95 wt % or more, 99 wt % or more, or any range including any of these integer values.

[0227] In some embodiments, the SG composition comprises RA, RB, RC, RD, RE, RF, rubusoside, STB, ST and DA, wherein the total SG content of these 10 SGs in the total SG composition is 50 wt % or more, 55 wt % or more, 60 wt % or more, 65 wt % or more, 70 wt % or more, 75 wt % or more, 80 wt % or more, 85 wt % or more, 90 wt % or more, or 95 wt % or more, wherein RA accounts for 20-35 wt % of the total SG content; wherein RB accounts for 20-35 wt % of the total SG content; 1-4wt% of the total SG content; wherein RC accounts for 5-15wt% of the total SG content; wherein RD accounts for 1-10wt% of the total SG content; wherein RE accounts for 0.1-2wt% of the total SG content; wherein RF accounts for 1-4wt% of the total SG content; wherein rubusoside accounts for 0.1-2wt% of the total SG content; wherein stevioside accounts for 1-5wt% of the total SG content; wherein stevioside accounts for 14-40wt% of the total SG content; and wherein dulcoside A accounts for 0.1-2wt% of the total SG content. In some embodiments, the total SG content of these 10 SGs in the total SG composition is 50-90wt%, 55-85wt%, 60-80wt% or 65-75wt%.

[0228] In some embodiments, the SG composition comprises RA, RC, RD, RF, RM, RN, rubusoside, steviol glycosides, and dulcoside A, wherein the total SG content of these 9 SGs in the total SG composition is 50 wt % or more, 55 wt % or more, 60 wt % or more, 65 wt % or more, 70 wt % or more, 75 wt % or more, 80 wt % or more, 85 wt % or more, 90 wt % or more, or 95 wt % or more, wherein RA accounts for 20-35 wt % of the total SG content; wherein RB accounts for 20-35 wt % of the total SG content. wherein RC accounts for 0-4wt% of the total SG content; wherein RC accounts for 5-15wt% of the total SG content; wherein RD accounts for 1-10wt% of the total SG content; wherein RE accounts for 0.1-2wt% of the total SG content; wherein RF accounts for 1-4wt% of the total SG content; wherein rubusoside accounts for 0.1-2wt% of the total SG content; wherein stevioside accounts for 1-5wt% of the total SG content; wherein stevioside accounts for 14-40wt% of the total SG content; and wherein dulcoside A accounts for 0.1-2wt% of the total SG content. In some embodiments, the total SG content of these 9 SGs in the total SG composition is 35-90wt%, 40-85wt%, 45-80wt%, 50-75wt%, 50-70wt%, 55-75wt% or 55-70%.

[0229] In some embodiments, the SG composition comprises RA, RB, RC, RD, RE, RF, rubusoside, stevioside, stevioside and dulcoside A, wherein the total SG content of these 10 SGs in the total SG composition is 70 wt% or more, wherein RA accounts for 20-35 wt% of the total SG content; wherein RB accounts for 0-4 wt% of the total SG content; wherein RC accounts for 5-15 wt% of the total SG content; wherein RD accounts for 1-10wt% of the total SG content; wherein RE accounts for 0.1-2wt% of the total SG content; wherein RF accounts for 1-4wt% of the total SG content; wherein rubusoside accounts for 0.1-2wt% of the total SG content; wherein stevioside accounts for 1-5wt% of the total SG content; wherein stevioside accounts for 14-40wt% of the total SG content; and wherein dulcoside A accounts for 0.1-2wt% of the total SG content.

[0230] In certain embodiments, the SG composition comprises RD and RM, wherein RD and RM account for less than 70wt%, less than 65wt%, less than 60wt%, less than 50wt%, less than 45wt%, less than 40wt%, less than 35wt%, less than 30wt%, less than 25wt%, less than 20wt%, less than 15wt%, less than 10wt% or less than 5wt% of the total SG content.

[0231] In certain embodiments, the SG composition comprises RA, RB, RC, RD, RE, RF, RebF1, RG, RebG1, RH, RI, RebI3, RJ, RK, RL, RM, RN, RO, RR, RebR1, RS, RU, RV, RebV2, RY, rubusoside, steviolbioside, steviol glycoside, steviol glycoside B, dulcoside A, and dulcoside B.

[0232] In some embodiments, the SG composition described herein comprises one or more SGs having a molecular weight equal to or greater than 803 Daltons.

[0233] In some embodiments, the SG composition comprises one or more SGs having a molecular weight equal to or greater than 803 Daltons and combinations thereof, and the content of the SG is 0-99%, 0-30wt%, 0-25wt%, 0-20wt%, 0-15wt%, 0-10wt%, 0-8wt%, 0-5wt%, 0-2wt%, 0-1wt%, 0-0.5wt%, 0.1-30wt%, 0.1-25wt%, 0.1 -20wt%, 0.1-15wt%, 0.1-10wt%, 0.1-8wt%, 0.1-5wt%, 0.1-2wt%, 0.1-1wt%, 0.1-0.5wt%, 0.5-30 wt%, 0.5-25wt%, 0.5-20wt%, 0.5-15wt%, 0.5-10wt%, 0.5-8wt%, 0.5-5wt%, 0.5-2wt%, 0.5-1wt%, 1-30wt%, 1-25wt%, 1-20wt%, 1-15wt%, 1-10wt%, 1-8wt%, 1-5wt%, 1-2wt%, 1.5-30wt%, 1.5-25wt% , 1.5-20wt%, 1.5-15wt%, 1.5-10wt%, 1.5-8wt%, 1.5-5wt%, 2-30wt%, 2-25wt%, 2-20wt%, 2-15wt% %, 2-10wt%, 2-8wt%, 2-5wt%, 3-30wt%, 3-25wt%, 3-20wt%, 3-15wt%, 3-10wt%, 3-8wt%, 3-5wt%, 5-30wt%, 5-25wt%, 5-20wt%, 5-15wt%, 5-10wt%, 5-8wt%, 10-30wt%, 10-25wt%, 10-20wt%, 10-15wt%. In certain embodiments, the composition contains no or substantially no one or more SGs having a MW>=803.

[0234] In some embodiments, the SG composition described herein comprises one or more SGs having a molecular weight equal to or greater than 935 Daltons.

[0235] In some embodiments, the SG composition comprises one or more SGs having a molecular weight equal to or greater than 935 Daltons and combinations thereof, and the content of the SG is 0-99%, 0-30wt%, 0-25wt%, 0-20wt%, 0-15wt%, 0-10wt%, 0-8wt%, 0-5wt%, 0-2wt%, 0-1wt%, 0-0.5wt%, 0.1-30wt%, 0.1-25wt%, 0.1 -20wt%, 0.1-15wt%, 0.1-10wt%, 0.1-8wt%, 0.1-5wt%, 0.1-2wt%, 0.1-1wt%, 0.1-0.5wt%, 0.5-30 wt%, 0.5-25wt%, 0.5-20wt%, 0.5-15wt%, 0.5-10wt%, 0.5-8wt%, 0.5-5wt%, 0.5-2wt%, 0.5-1wt%, 1-30wt%, 1-25wt%, 1-20wt%, 1-15wt%, 1-10wt%, 1-8wt%, 1-5wt%, 1-2wt%, 1.5-30wt%, 1.5-25wt% , 1.5-20wt%, 1.5-15wt%, 1.5-10wt%, 1.5-8wt%, 1.5-5wt%, 2-30wt%, 2-25wt%, 2-20wt%, 2-15wt% %, 2-10wt%, 2-8wt%, 2-5wt%, 3-30wt%, 3-25wt%, 3-20wt%, 3-15wt%, 3-10wt%, 3-8wt%, 3-5wt%, 5-30wt%, 5-25wt%, 5-20wt%, 5-15wt%, 5-10wt%, 5-8wt%, 10-30wt%, 10-25wt%, 10-20wt%, 10-15wt%. In certain embodiments, the composition is free of or substantially free of one or more SGs having a MW>=935.

[0236] In some embodiments, the SG composition described herein comprises one or more SGs having a molecular weight equal to or greater than 949 Daltons.

[0237] In some embodiments, the SG composition comprises one or more SGs having a molecular weight equal to or greater than 949 Daltons and combinations thereof, and the content of the SG is 0-99%, 0-30wt%, 0-25wt%, 0-20wt%, 0-15wt%, 0-10wt%, 0-8wt%, 0-5wt%, 0-2wt%, 0-1wt%, 0-0.5wt%, 0.1-30wt%, 0.1-25wt%, 0.1 -20wt%, 0.1-15wt%, 0.1-10wt%, 0.1-8wt%, 0.1-5wt%, 0.1-2wt%, 0.1-1wt%, 0.1-0.5wt%, 0.5-30 wt%, 0.5-25wt%, 0.5-20wt%, 0.5-15wt%, 0.5-10wt%, 0.5-8wt%, 0.5-5wt%, 0.5-2wt%, 0.5-1wt%, 1-30wt%, 1-25wt%, 1-20wt%, 1-15wt%, 1-10wt%, 1-8wt%, 1-5wt%, 1-2wt%, 1.5-30wt%, 1.5-25wt% , 1.5-20wt%, 1.5-15wt%, 1.5-10wt%, 1.5-8wt%, 1.5-5wt%, 2-30wt%, 2-25wt%, 2-20wt%, 2-15wt% %, 2-10wt%, 2-8wt%, 2-5wt%, 3-30wt%, 3-25wt%, 3-20wt%, 3-15wt%, 3-10wt%, 3-8wt%, 3-5wt%, 5-30wt%, 5-25wt%, 5-20wt%, 5-15wt%, 5-10wt%, 5-8wt%, 10-30wt%, 10-25wt%, 10-20wt%, 10-15wt%. In certain embodiments, the composition contains no or substantially no one or more SGs having a MW>=949.

[0238] In some embodiments, the SG composition described herein comprises one or more SGs having a molecular weight equal to or greater than 965 Daltons.

[0239] In some embodiments, the SG composition comprises one or more SGs having a molecular weight equal to or greater than 965 Daltons and combinations thereof, and the content of the SG is 0-99%, 0-30wt%, 0-25wt%, 0-20wt%, 0-15wt%, 0-10wt%, 0-8wt%, 0-5wt%, 0-2wt%, 0-1wt%, 0-0.5wt%, 0.1-30wt%, 0.1-25wt%, 0.1 -20wt%, 0.1-15wt%, 0.1-10wt%, 0.1-8wt%, 0.1-5wt%, 0.1-2wt%, 0.1-1wt%, 0.1-0.5wt%, 0.5-30 wt%, 0.5-25wt%, 0.5-20wt%, 0.5-15wt%, 0.5-10wt%, 0.5-8wt%, 0.5-5wt%, 0.5-2wt%, 0.5-1wt%, 1-30wt%, 1-25wt%, 1-20wt%, 1-15wt%, 1-10wt%, 1-8wt%, 1-5wt%, 1-2wt%, 1.5-30wt%, 1.5-25wt% , 1.5-20wt%, 1.5-15wt%, 1.5-10wt%, 1.5-8wt%, 1.5-5wt%, 2-30wt%, 2-25wt%, 2-20wt%, 2-15wt% %, 2-10wt%, 2-8wt%, 2-5wt%, 3-30wt%, 3-25wt%, 3-20wt%, 3-15wt%, 3-10wt%, 3-8wt%, 3-5wt%, 5-30wt%, 5-25wt%, 5-20wt%, 5-15wt%, 5-10wt%, 5-8wt%, 10-30wt%, 10-25wt%, 10-20wt%, 10-15wt%. In certain embodiments, the composition is free of or substantially free of one or more SGs having a MW>=965.

[0240] In some embodiments, the SG composition described herein comprises one or more SGs having a molecular weight equal to or greater than 981 Daltons.

[0241] In some embodiments, the SG composition comprises one or more SGs having a molecular weight equal to or greater than 981 Daltons and combinations thereof, and the content of the SG is 0-99%, 0-30wt%, 0-25wt%, 0-20wt%, 0-15wt%, 0-10wt%, 0-8wt%, 0-5wt%, 0-2wt%, 0-1wt%, 0-0.5wt%, 0.1-30wt%, 0.1-25wt%, 0.1 -20wt%, 0.1-15wt%, 0.1-10wt%, 0.1-8wt%, 0.1-5wt%, 0.1-2wt%, 0.1-1wt%, 0.1-0.5wt%, 0.5-30 wt%, 0.5-25wt%, 0.5-20wt%, 0.5-15wt%, 0.5-10wt%, 0.5-8wt%, 0.5-5wt%, 0.5-2wt%, 0.5-1wt%, 1-30wt%, 1-25wt%, 1-20wt%, 1-15wt%, 1-10wt%, 1-8wt%, 1-5wt%, 1-2wt%, 1.5-30wt%, 1.5-25wt% , 1.5-20wt%, 1.5-15wt%, 1.5-10wt%, 1.5-8wt%, 1.5-5wt%, 2-30wt%, 2-25wt%, 2-20wt%, 2-15wt% %, 2-10wt%, 2-8wt%, 2-5wt%, 3-30wt%, 3-25wt%, 3-20wt%, 3-15wt%, 3-10wt%, 3-8wt%, 3-5wt%, 5-30wt%, 5-25wt%, 5-20wt%, 5-15wt%, 5-10wt%, 5-8wt%, 10-30wt%, 10-25wt%, 10-20wt%, 10-15wt%. In certain embodiments, the composition is free of or substantially free of one or more SGs having a MW>=981.

[0242] In some embodiments, the SG composition described herein comprises one or more SGs having a molecular weight equal to or greater than 1097 Daltons.

[0243] In some embodiments, the SG composition comprises one or more SGs having a molecular weight equal to or greater than 1097 Daltons and combinations thereof, and the content of the SG is 0-99%, 0-30wt%, 0-25wt%, 0-20wt%, 0-15wt%, 0-10wt%, 0-8wt%, 0-5wt%, 0-2wt%, 0-1wt%, 0-0.5wt%, 0.1-30wt%, 0.1-25wt%, 0.1 -20wt%, 0.1-15wt%, 0.1-10wt%, 0.1-8wt%, 0.1-5wt%, 0.1-2wt%, 0.1-1wt%, 0.1-0.5wt%, 0.5-30 wt%, 0.5-25wt%, 0.5-20wt%, 0.5-15wt%, 0.5-10wt%, 0.5-8wt%, 0.5-5wt%, 0.5-2wt%, 0.5-1wt%, 1-30wt%, 1-25wt%, 1-20wt%, 1-15wt%, 1-10wt%, 1-8wt%, 1-5wt%, 1-2wt%, 1.5-30wt%, 1.5-25wt% , 1.5-20wt%, 1.5-15wt%, 1.5-10wt%, 1.5-8wt%, 1.5-5wt%, 2-30wt%, 2-25wt%, 2-20wt%, 2-15wt% %, 2-10wt%, 2-8wt%, 2-5wt%, 3-30wt%, 3-25wt%, 3-20wt%, 3-15wt%, 3-10wt%, 3-8wt%, 3-5wt%, 5-30wt%, 5-25wt%, 5-20wt%, 5-15wt%, 5-10wt%, 5-8wt%, 10-30wt%, 10-25wt%, 10-20wt%, 10-15wt%. In certain embodiments, the composition is free of or substantially free of one or more SGs having a MW>=1097.

[0244] In some embodiments, the SG composition described herein comprises one or more SGs having a molecular weight equal to or greater than 1111 Daltons.

[0245] In some embodiments, the SG composition comprises one or more SGs having a molecular weight equal to or greater than 1111 Daltons and combinations thereof, and the content of the SG is 0-99%, 0-30wt%, 0-25wt%, 0-20wt%, 0-15wt%, 0-10wt%, 0-8wt%, 0-5wt%, 0-2wt%, 0-1wt%, 0-0.5wt%, 0.1-30wt%, 0.1-25wt%, 0.1 -20wt%, 0.1-15wt%, 0.1-10wt%, 0.1-8wt%, 0.1-5wt%, 0.1-2wt%, 0.1-1wt%, 0.1-0.5wt%, 0.5-30 wt%, 0.5-25wt%, 0.5-20wt%, 0.5-15wt%, 0.5-10wt%, 0.5-8wt%, 0.5-5wt%, 0.5-2wt%, 0.5-1wt%, 1-30wt%, 1-25wt%, 1-20wt%, 1-15wt%, 1-10wt%, 1-8wt%, 1-5wt%, 1-2wt%, 1.5-30wt%, 1.5-25wt% , 1.5-20wt%, 1.5-15wt%, 1.5-10wt%, 1.5-8wt%, 1.5-5wt%, 2-30wt%, 2-25wt%, 2-20wt%, 2-15wt% %, 2-10wt%, 2-8wt%, 2-5wt%, 3-30wt%, 3-25wt%, 3-20wt%, 3-15wt%, 3-10wt%, 3-8wt%, 3-5wt%, 5-30wt%, 5-25wt%, 5-20wt%, 5-15wt%, 5-10wt%, 5-8wt%, 10-30wt%, 10-25wt%, 10-20wt%, 10-15wt%. In certain embodiments, the composition does not contain or is substantially free of one or more SGs having a MW>=1111.

[0246] In some embodiments, the SG composition described herein comprises one or more SGs having a molecular weight equal to or greater than 1127 Daltons.

[0247] In some embodiments, the SG composition comprises one or more SGs having a molecular weight equal to or greater than 1127 Daltons and combinations thereof, and the content of the SG is 0-99%, 0-30wt%, 0-25wt%, 0-20wt%, 0-15wt%, 0-10wt%, 0-8wt%, 0-5wt%, 0-2wt%, 0-1wt%, 0-0.5wt%, 0.1-30wt%, 0.1-25wt%, 0.1 -20wt%, 0.1-15wt%, 0.1-10wt%, 0.1-8wt%, 0.1-5wt%, 0.1-2wt%, 0.1-1wt%, 0.1-0.5wt%, 0.5-30 wt%, 0.5-25wt%, 0.5-20wt%, 0.5-15wt%, 0.5-10wt%, 0.5-8wt%, 0.5-5wt%, 0.5-2wt%, 0.5-1wt%, 1-30wt%, 1-25wt%, 1-20wt%, 1-15wt%, 1-10wt%, 1-8wt%, 1-5wt%, 1-2wt%, 1.5-30wt%, 1.5-25wt% , 1.5-20wt%, 1.5-15wt%, 1.5-10wt%, 1.5-8wt%, 1.5-5wt%, 2-30wt%, 2-25wt%, 2-20wt%, 2-15wt% %, 2-10wt%, 2-8wt%, 2-5wt%, 3-30wt%, 3-25wt%, 3-20wt%, 3-15wt%, 3-10wt%, 3-8wt%, 3-5wt%, 5-30wt%, 5-25wt%, 5-20wt%, 5-15wt%, 5-10wt%, 5-8wt%, 10-30wt%, 10-25wt%, 10-20wt%, 10-15wt%. In certain embodiments, the composition is free of or substantially free of one or more SGs having a MW>=1127.

[0248] In some embodiments, the SG composition described herein comprises one or more SGs having a molecular weight equal to or greater than 1259 Daltons.

[0249] In some embodiments, the SG composition comprises one or more SGs having a molecular weight equal to or greater than 1259 Daltons and combinations thereof, and the content of the SG is 0-99%, 0-30wt%, 0-25wt%, 0-20wt%, 0-15wt%, 0-10wt%, 0-8wt%, 0-5wt%, 0-2wt%, 0-1wt%, 0-0.5wt%, 0.1-30wt%, 0.1-25wt%, 0.1 -20wt%, 0.1-15wt%, 0.1-10wt%, 0.1-8wt%, 0.1-5wt%, 0.1-2wt%, 0.1-1wt%, 0.1-0.5wt%, 0.5-30 wt%, 0.5-25wt%, 0.5-20wt%, 0.5-15wt%, 0.5-10wt%, 0.5-8wt%, 0.5-5wt%, 0.5-2wt%, 0.5-1wt%, 1-30wt%, 1-25wt%, 1-20wt%, 1-15wt%, 1-10wt%, 1-8wt%, 1-5wt%, 1-2wt%, 1.5-30wt%, 1.5-25wt% , 1.5-20wt%, 1.5-15wt%, 1.5-10wt%, 1.5-8wt%, 1.5-5wt%, 2-30wt%, 2-25wt%, 2-20wt%, 2-15wt% %, 2-10wt%, 2-8wt%, 2-5wt%, 3-30wt%, 3-25wt%, 3-20wt%, 3-15wt%, 3-10wt%, 3-8wt%, 3-5wt%, 5-30wt%, 5-25wt%, 5-20wt%, 5-15wt%, 5-10wt%, 5-8wt%, 10-30wt%, 10-25wt%, 10-20wt%, 10-15wt%. In certain embodiments, the composition is free of or substantially free of one or more SGs having a MW>=1259.

[0250] In some embodiments, the SG composition described herein comprises one or more SGs having a molecular weight equal to or greater than 1273 Daltons.

[0251] In some embodiments, the SG composition comprises one or more SGs having a molecular weight equal to or greater than 1273 Daltons and combinations thereof, and the content of the SG is 0-99%, 0-30wt%, 0-25wt%, 0-20wt%, 0-15wt%, 0-10wt%, 0-8wt%, 0-5wt%, 0-2wt%, 0-1wt%, 0-0.5wt%, 0.1-30wt%, 0.1-25wt%, 0.1 -20wt%, 0.1-15wt%, 0.1-10wt%, 0.1-8wt%, 0.1-5wt%, 0.1-2wt%, 0.1-1wt%, 0.1-0.5wt%, 0.5-30 wt%, 0.5-25wt%, 0.5-20wt%, 0.5-15wt%, 0.5-10wt%, 0.5-8wt%, 0.5-5wt%, 0.5-2wt%, 0.5-1wt%, 1-30wt%, 1-25wt%, 1-20wt%, 1-15wt%, 1-10wt%, 1-8wt%, 1-5wt%, 1-2wt%, 1.5-30wt%, 1.5-25wt% , 1.5-20wt%, 1.5-15wt%, 1.5-10wt%, 1.5-8wt%, 1.5-5wt%, 2-30wt%, 2-25wt%, 2-20wt%, 2-15wt% %, 2-10wt%, 2-8wt%, 2-5wt%, 3-30wt%, 3-25wt%, 3-20wt%, 3-15wt%, 3-10wt%, 3-8wt%, 3-5wt%, 5-30wt%, 5-25wt%, 5-20wt%, 5-15wt%, 5-10wt%, 5-8wt%, 10-30wt%, 10-25wt%, 10-20wt%, 10-15wt%. In certain embodiments, the composition does not contain or is substantially free of one or more SGs having a MW>=1273.

[0252] In some embodiments, the SG composition described herein comprises one or more SGs having a molecular weight equal to or greater than 1289 Daltons.

[0253] In some embodiments, the SG composition comprises one or more SGs having a molecular weight equal to or greater than 1289 Daltons and combinations thereof, and the content of the SG is 0-99%, 0-30wt%, 0-25wt%, 0-20wt%, 0-15wt%, 0-10wt%, 0-8wt%, 0-5wt%, 0-2wt%, 0-1wt%, 0-0.5wt%, 0.1-30wt%, 0.1-25wt%, 0.1 -20wt%, 0.1-15wt%, 0.1-10wt%, 0.1-8wt%, 0.1-5wt%, 0.1-2wt%, 0.1-1wt%, 0.1-0.5wt%, 0.5-30 wt%, 0.5-25wt%, 0.5-20wt%, 0.5-15wt%, 0.5-10wt%, 0.5-8wt%, 0.5-5wt%, 0.5-2wt%, 0.5-1wt%, 1-30wt%, 1-25wt%, 1-20wt%, 1-15wt%, 1-10wt%, 1-8wt%, 1-5wt%, 1-2wt%, 1.5-30wt%, 1.5-25wt% , 1.5-20wt%, 1.5-15wt%, 1.5-10wt%, 1.5-8wt%, 1.5-5wt%, 2-30wt%, 2-25wt%, 2-20wt%, 2-15wt% %, 2-10wt%, 2-8wt%, 2-5wt%, 3-30wt%, 3-25wt%, 3-20wt%, 3-15wt%, 3-10wt%, 3-8wt%, 3-5wt%, 5-30wt%, 5-25wt%, 5-20wt%, 5-15wt%, 5-10wt%, 5-8wt%, 10-30wt%, 10-25wt%, 10-20wt%, 10-15wt%. In certain embodiments, the composition is free of or substantially free of one or more SGs having a MW>=1289.

[0254] In some embodiments, the SG composition described herein comprises one or more SGs having a molecular weight equal to or greater than 1305 Daltons.

[0255] In some embodiments, the SG composition comprises one or more SGs having a molecular weight equal to or greater than 1305 Daltons and combinations thereof, and the content of the SG is 0-99%, 0-30wt%, 0-25wt%, 0-20wt%, 0-15wt%, 0-10wt%, 0-8wt%, 0-5wt%, 0-2wt%, 0-1wt%, 0-0.5wt%, 0.1-30wt%, 0.1-25wt%, 0.1 -20wt%, 0.1-15wt%, 0.1-10wt%, 0.1-8wt%, 0.1-5wt%, 0.1-2wt%, 0.1-1wt%, 0.1-0.5wt%, 0.5-30 wt%, 0.5-25wt%, 0.5-20wt%, 0.5-15wt%, 0.5-10wt%, 0.5-8wt%, 0.5-5wt%, 0.5-2wt%, 0.5-1wt%, 1-30wt%, 1-25wt%, 1-20wt%, 1-15wt%, 1-10wt%, 1-8wt%, 1-5wt%, 1-2wt%, 1.5-30wt%, 1.5-25wt% , 1.5-20wt%, 1.5-15wt%, 1.5-10wt%, 1.5-8wt%, 1.5-5wt%, 2-30wt%, 2-25wt%, 2-20wt%, 2-15wt% %, 2-10wt%, 2-8wt%, 2-5wt%, 3-30wt%, 3-25wt%, 3-20wt%, 3-15wt%, 3-10wt%, 3-8wt%, 3-5wt%, 5-30wt%, 5-25wt%, 5-20wt%, 5-15wt%, 5-10wt%, 5-8wt%, 10-30wt%, 10-25wt%, 10-20wt%, 10-15wt%. In certain embodiments, the composition is free of or substantially free of one or more SGs having a MW>=1305.

[0256] In some embodiments, the SG composition described herein comprises one or more SGs having a molecular weight equal to or greater than 1435 Daltons.

[0257] In some embodiments, the SG composition comprises one or more SGs having a molecular weight equal to or greater than 1435 Daltons and combinations thereof, and the content of the SG is 0-99%, 0-30wt%, 0-25wt%, 0-20wt%, 0-15wt%, 0-10wt%, 0-8wt%, 0-5wt%, 0-2wt%, 0-1wt%, 0-0.5wt%, 0.1-30wt%, 0.1-25wt%, 0.1 -20wt%, 0.1-15wt%, 0.1-10wt%, 0.1-8wt%, 0.1-5wt%, 0.1-2wt%, 0.1-1wt%, 0.1-0.5wt%, 0.5-30 wt%, 0.5-25wt%, 0.5-20wt%, 0.5-15wt%, 0.5-10wt%, 0.5-8wt%, 0.5-5wt%, 0.5-2wt%, 0.5-1wt%, 1-30wt%, 1-25wt%, 1-20wt%, 1-15wt%, 1-10wt%, 1-8wt%, 1-5wt%, 1-2wt%, 1.5-30wt%, 1.5-25wt% , 1.5-20wt%, 1.5-15wt%, 1.5-10wt%, 1.5-8wt%, 1.5-5wt%, 2-30wt%, 2-25wt%, 2-20wt%, 2-15wt% %, 2-10wt%, 2-8wt%, 2-5wt%, 3-30wt%, 3-25wt%, 3-20wt%, 3-15wt%, 3-10wt%, 3-8wt%, 3-5wt%, 5-30wt%, 5-25wt%, 5-20wt%, 5-15wt%, 5-10wt%, 5-8wt%, 10-30wt%, 10-25wt%, 10-20wt%, 10-15wt%. In certain embodiments, the composition is free of or substantially free of one or more SGs having a MW>=1435.

[0258] Even though the SG or SG composition is targeted for long term solubility at room temperature, the current embodiments may include temperatures in the range of 0 to 25° C. Even though the stability range of the current embodiments is targeted for stability between 0 to 25° C., good stability outside this range, especially at temperatures above this range, can be expected.

[0259] Typically, the solubility of individual steviol glycosides is poor. In one embodiment, the solubility of a first SG can be improved by adding a second SG in an aqueous solution, dissolving the SG as a composition at elevated temperature, and then cooling to ambient temperature.

[0260] In another embodiment, the solubility of the two SGs in the SG starting composition can be further increased by adding at least a third SG in the aqueous solution, dissolving the SGs at elevated temperature, and then lowering the temperature to ambient temperature.

[0261] An aspect of this embodiment provides a treated SG or SG composition having improved solubility in aqueous solution compared to an untreated SG or SG composition comprising rebaudioside A, B and D individually or a mixture thereof.For example, the solubility of the treated SG or SG composition in aqueous solution at ambient temperature is about ≥1 g / 100 g water, preferably about ≥3 g / 100 g water, more preferably about ≥5 g / 100 g water, more preferably about ≥10 g / 100 g water, more preferably about ≥15 g / 100 g water, more preferably about ≥20 g / 100 g water, more preferably about ≥25 g / 100 g water, more preferably about ≥30 g / 100 g water, more preferably about ≥35 g / 100 g water, more preferably about ≥40 g / 100 g water, more preferably about ≥45 g / 100 g water, more preferably about ≥50 g / 100 g water, more preferably about ≥55 g / 100 g water, and most preferably about ≥60 g / 100 g water. g water, and all ranges therebetween from about 1 g / 100 g water to about 60 g / 100 g water, for example, from about 1 g / 100 g water to about 5 g / 100 g water, from about 1 g / 100 g water to about 10 g / 100 g water, from about 2 g / 100 g water to about 5 g / 100 g water, from about 2 g / 100 g water to about 10 g / 100 g water, from about 3 g / 100 g water to about 5 g / 100 g water, from about 3 g / 100 g water to about 15 g / 100 g water, from about 5 g / 100 g water to about 10 g / 100 g water, from about 5 g / 100 g water to about 15 g / 100 g water, from about 5 g / 100 g water to about 20 g / 100 g water, from about 7 g / 100 g water to about 10 g / 100g water, about 7g / 100g water to, 15g / 100g water, about 7g / 100g water to about 20g / 100g water, about 10g / 100g water to about 15g / 100g water, about 10g / 100g water to about 20g / 100g water, about 10g / 100g water to about 25g / 100g water, about 10g / 100g water to about 30g / 100g water, about 12g / 100g water to about 20g / 100g water, about 12g / 100g water to about 25g / 100g water, about 12g / 100g water to about 30g / 100g water, about 15g / 100g water to about 20g / 100g water, about 15g / 100g water g water to about 25 g / 100 g water, about 17 g / 100 g water to about 20 g / 100 g water, about 17 g / 100 g water to about 25 g / 100 g water, about 17 g / 100 g water to about 30 g / 100 g water, about 20 g / 100 g water to about 25 g / 100 g water, about 20 g / 100 g water to about 30 g / 100 g water, about 20 g / 100 g water to about 40 g / 100 g water, about 20 g / 100 g water to about 50 g / 100 g water, about 25 g / 100 g water to about 30 g / 100 g water, about 25 g / 100 g water to about 40 g / 100 g water, about 25 g / 100 g water to about 50 g / 100 g water.

[0262] In certain embodiments, the SG or SG composition of the present embodiment is described by its stability in water or water / alcohol solution. As described herein, the stability of the SG or SG composition of the present embodiment refers to the solubility of the raw material measured in the range of 0-25° C. with no crystallization, no precipitation, minimal precipitation or crystallization. The lower limit of the temperature range should not be limited, and it should be understood that the SG or SG composition, once dissolved, can remain soluble above 25° C.

[0263] The single SG or the plurality of SGs of the SG composition may each independently be in an amorphous form, each independently be in a polymorphic form or a mixed form thereof.

[0264] Preferably, the single SG or multiple SGs of the SG composition according to one embodiment are in an amorphous form, but may also be in a polymorphic form.

[0265] On the other hand, one embodiment provides an aqueous sweetener concentrate comprising a treated SG or SG composition, wherein the total solubility of SG is increased compared to the maximum total content of untreated SG in water or water / alcohol under the same conditions. For example, according to the present invention, the total content of SG in water in the aqueous sweetener concentrate comprising SG or SG composition is ≥1% wt / wt, preferably ≥5% wt / wt, more preferably ≥10% wt / wt, more preferably ≥15% wt / wt, more preferably ≥20% wt / wt, more preferably ≥25% wt / wt, more preferably ≥30% wt / wt, more preferably ≥35% wt / wt, more preferably ≥40% wt / wt, more preferably ≥45% wt / wt, and preferably ≥50% wt / wt, and most preferably ≥60% wt / wt, and all ranges between 1% wt / wt and 100% wt / wt, for example, from about 1% wt / wt to about 99% wt / wt, about 5% wt / wt t / wt to about 95% wt / wt, about 10% wt / wt to about 90% wt / wt, about 15% wt / wt to about 85% wt / wt, about 20% wt / wt to about 80% wt / wt, about 25% wt / wt to about 80% wt / wt, about 30% wt / wt to about 80% wt / wt, about 35% wt / wt to about 80% wt / wt, about 40% wt / wt to about 80% wt / wt, about 45% wt / wt to about 75% wt / wt, about 50% wt / wt to about 75% wt / wt, about 55% wt / wt to about 75% wt / wt, about 55% wt / wt to about 70% wt / wt, and about 55% wt / wt to about 65% wt / wt.

[0266] On the one hand, in an exemplary composition containing two different SGs, the components can have a ratio of 1:99, 2:98, 3:97, 4:96, 5:95, 6:94, 7:93, 8:92, 9:91, 10:90, 11:89, 12:88, 13:87, 14:86, 15:85, 16:84, 17:83, 18:82, 19:81, 20:80, 21:79, 22:78, 23:77, 24:76, 25:75, 26:74, 27:73, 28:72 , 29:71, 30:70, 31:69, 32:68, 33:67, 34:66, 35:65, 36:64, 37:63, 38:62, 39:61, 40:60, 41:59, 42:58, 43:57, 44:56, 45:55, 46:54, 47:53, 48:52, 49:51 and 50:50, and all ranges therebetween where the ratio is 1:99, and vice versa, for example, the ratio is from 1:99 to 50:50, from 30:70 to 42:58, etc.

[0267] On the other hand, in an exemplary composition containing three different SGs, the components may have a ratio of 1:1:98, 1:2:97, 1:3:96, 1:4:95, 1:5:94, 1:6:93, 1:7:92, 1:8:91, 1:9:90, 1:10:89, 1:11:88, 1:12:87, 1:13:86, 1:14:85, 1:15:84, 1:16:83, 1:17:82, 1:18:81, 1:19:80, 1:20:79, 1:21:78, 1:22:77, 1:23:76, 1:24:75, 1:25:74, 1:26:73, 1:27:72, 1:28:7 1, 1:29:70, 1:30:69, 1:31:68, 1:32:67, 2:3:95, 2:4:94, 2:5:93, 2:6:92, 2:7:91, 2:8:90, 2:9:89, 2:10:88, 2:11:87, 2:12:86, 2:13:85, 2:14:84, 2 :15:83, 2:16:82, 2:17:81, 2:18:80, 2:19:79, 2:20:78, 2:21:77, 2:22:76, 2:23:75, 2:24:74, 2:25:73, 2:26:72, 2:27:71, 2:28:70, 2:29:69, 2:30:6 8, 2:31:67, 2:32:66, 2:3:95, 3:3:94, 3:4:93, 3:5:92, 3:6:91, 3:7:90, 3:8:89, 3:9:88, 3:10:87, 3:11:86, 3:12:85, 3:13:84, 3:14:83, 3:15:82, 3: 16:81, 2:17:80, 3:18:79, 3:19:78, 3:20:77, 3:21:76, 3:22:75, 3:23:74, 3:24:73, 3:25:72, 3:26:71, 3:27:70, 3:28:69, 3:29:68, 3:30:67, 3:31:66 , 3:32:65, 4:4:92, 4:5:91, 4:6:90, 4:7:89, 4:8:88, 4:9:87, 4:10:86, 4:11:85, 4:12:84, 4:13:83, 4:14:82, 4:15:81, 4:16:80, 4:17:79, 4:18:78, 4 :19:77, 4:20:76, ​​4:21:75, 4:22:74, 4:23:73, 4:24:72, 4:25:71, 4:26:70, 4:27:69, 4:28:68, 4:29:67, 4:30:66, 4:31:65, 4:32:64, 5:5:90, 5:6:89,5:7:88，5:8:87，5:9:86，5:10:85，

[0268] 5:11:84，5:12:83，5:13:82，5:14:81，5:15:80，5:16:79，5:17:78，5:18:77，

[0269] 5:19:76，5:20:75，5:21:74，5:22:73，5:23:72，5:24:71，5:25:70，5:26:69，

[0270] 5:27:68，5:28:67，5:29:66，5:30:65，5:31:64，5:32:63，6:6:88，6:7:87，

[0271] 6:8:86，6:9:85，6:10:84，6:11:83，6:12:82，6:13:81，6:14:80，6:15:79，

[0272] 6:16:78，6:17:77,6:18:76,6:19:75,6:20:74,6:21:73,6:22:72,6:23:71,

[0273] 6:24:70,6:25:69,6:26:68,6:27:67,6:28:66,6:29:65,6:30:64,6:31:63,

[0274] 6:32:62,7:7:86,7:8:85,7:9:84,7:10:83,7:11:82,7:12:81,7:13:80,

[0275] 7:14:79,7:15:78,7:16:77,7:17:76,7:18:75,7:19:74,7:20:73,7:21:72,

[0276] 7:22:71,7:23:70,7:24:69,7:25:68,7:26:67,7:27:66,7:28:65,7:29:64,

[0277] 7:30:63,7:31:62,7:32:61,8:8:84,8:9:83,8:10:82,8:11:81,8:12:80,

[0278] 8:13:79,8:14:78,8:15:77,8:16:76,8:17:75,8:18:74,8:19:73,8:20:72,

[0279] 8:21:71,8:22:70,8:23:69,8:24:68,8:25:67,8:26:66,8:27:65,8:28:64,

[0280] 8:29:63,8:30:62,8:31:61,8:32:60,9:9:82,9:10:81,9:11:80,9:12:79,

[0281] 9:13:78,9:14:77,9:15:76,9:16:75,9:17:74,9:18:73,9:19:72,9:20:71,

[0282] 9:21:70,9:22:69,9:23:68,9:24:67,9:25:66,9:26:65,9:27:64,9:28:63,

[0283] 9:29:62,9:30:61,9:31:60,9:32:59,10:10:80,10:11:79,10:12:78,

[0284] 10:13:77,10:14:76,10:15:75,10:16:74,10:17:73,10:18:72,10:19:71,

[0285] 10:20:70,10:21:69,10:22:68,10:23:67,10:24:66,10:25:65,10:26:64,

[0286] 10:27:63,10:28:62,10:29:61,10:30:60,10:31:59,10:32:58,11:11:78,

[0287] 11:12:77,11:13:76,11:14:75,11:15:74,11:16:73,11:17:72,11:18:71,

[0288] 11:19:70,11:20:69,11:21:68,11:22:67,11:23:66,11:24:65,11:25:64,

[0289] 11:26:63,11:27:62,11:28:61,11:29:60,11:30:59,11:31:58,11:32:57,

[0290] 12:12:76,12:13:75,12:14:74,12:15:73,12:16:72,12:17:71,12:18:70,

[0291] 12:19:69,12:20:68,12:21:67,12:22:66,12:23:65,12:24:64,12:25:63,

[0292] 12:26:62,12:27:61,12:28:60,12:29:59,12:30:58,12:31:57,12:32:56,

[0293] 13:13:74,13:14:73,13:15:72,13:16:71,13:17:70,13:18:69,13:19:68,

[0294] 13:20:67,13:21:66,13:22:65,13:23:64,13:24:63,13:25:62,13:26:61,

[0295] 13:27:60,13:28:59,13:29:58,13:30:57,13:31:56,13:32:55,14:14:72,

[0296] 14:15:71,14:16:70,14:17:69,14:18:68,14:19:67,14:20:66,14:21:65,14:22:64,14:23:63,14:24:62,14:25:61,14:26:60,14:27:59,14:28:58,14:29:57,14:30:56,14:31:55,14:32:54,15:15:70,15:16:69,15:17:68,15:18:67,15:19:66,15:20:65,15:21:64,15:22:63,15:23:62,15:24:61,15:25:60,15:26:59,15:27:58,17:28:57,15:29:56,15:30:55,15:31:54,15:32:53,16:16:68,16:17:67,16:18:66,16:19:65,16:20:64,16:21:63,16:22:62,16:23:61,16:24:60,16:25:59,16:26:58,16:27:57,16:28:56,16:29:55,16:30:54,16:31:53,16:32:52,17:17:66,17:18:65,17:19:64,17:20:63,17:21:62,17:22:61,17:23:60,17:24:59,17:25:58,17:26:57,17:27:56,17:28:55,17:29:54,17:30:53,17:31:52,17:32:51,18:18:64,18:19:63,18:20:62,18:21:61,18:22:60,18:23:59,18:24:58,18:25:57,18:26:56,18:27:55,18:28:54,18:29:53,18:30:52,18:31:51,18:32:50,19:19:62,19:20:61,19:21:60,19:22:59,19:23:58,19:24:57,19:25:56,19:26:55,19:27:54,19:28:53,19:29:52,19:30:51,19:31:50,19:32:49,20:20:60,20:21:59,20:22:58,20:23:57,20:24:56,20:25:55,20:26:54,20:27:53,20:28:52,20:29:51,20:30:50,20:31:49,20:32:48,21:21:58,21:22:57,21:23:56,21:24:55,21:25:54,21:26:53,21:27:52,21:28:51,21:29:50,21:30:49,21:31:48,21:32:47,22:22:56,22:23:55,22:24:54,22:25:53,22:26:52,22:27:51,22:28:50,22:29:49,22:30:48,22:31:47,22: 32:46,23:23:54,23:24:53,23:25:52,23:26:51,23:27:50,23:28:49,23:29:48,23:30:47,23:31:46,23:32:45,24:24:52,24:25:51,24:26:50,24:27:49,24:28:48,24:29:47,24:30:46,24:31:45,24:32:44,25:25:50,25:26:49,25:27: 48,25:28:47,25:29:46,25:30:45,25:31:44,25:32:43,26:26:48,26:27:47,26:28:46,26:29:45,26:30:44,26:31:43,26:32:42,27:27:46,27:28:45,27:29:44,27:30:43,27:31:42,27:32:41,28:28:44,28:29:43,28:30:42,28:31:41, 28:32:40,29:29:42,29:30:41,29:31:40,29:32:39,30:30:40,30:31:39,30:32:38,31:31:38,31:32:37,32:32:36,32:33:35, and 33.3:33.3:33.3, and all ranges therebetween, where the ratio is 1:1:98 and vice versa, for example, from 1:1:99 to 33.3:33.3:33.3, from 10:30:70 to 15:40:45, etc. ,

[0297] It is worth noting that the present invention is not limited to compositions containing only two or three different SG components, and those exemplary ratios are non-limiting. Instead, the same formula can be followed to determine the ratios of many different SG components contained in a given composition. As a further example, in a composition containing 20 different SG components, the components can have ratios of 1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:81 to 5:5:5:5:5:5:5:5:5:5:5:5:5:5:5:5:5:5:5:5 and all possible combinations of ratios therebetween. In some embodiments, the compositions of the present invention may contain all of the compositions and combinations contained in Table 1.

[0298] C. Non-SG sweeteners

[0299] On the other hand, the sweetener composition of the present application comprises one or more treated SGs, and under the same conditions, the solubility in water or water / alcohol is improved compared with that of untreated SGs (which may be individual rebaudioside A, B and D or a mixture thereof). Optionally, the composition further comprises other sweeteners and / or additional additives further described below.

[0300] The one or more non-SG sweeteners of the SG composition in the present application include, but are not limited to, natural sweeteners, natural high-potency sweeteners, synthetic sweeteners, or combinations thereof.

[0301] "Natural sweeteners" as described herein refer to any sweeteners naturally occurring in nature, excluding SG. The phrase "natural high-potency sweeteners" refers to any sweeteners naturally occurring in nature, and have a sweetening potency higher than sucrose, fructose or glucose, yet have fewer calories. The terms "natural sweeteners", "natural high-potency sweeteners" and "synthetic sweeteners" as described herein do not include SG.

[0302] In certain embodiments, the non-SG sweetener comprises at least one carbohydrate sweetener. Exemplary carbohydrate sweeteners are selected from, but are not limited to, sucrose, glyceraldehyde, dihydroxyacetone, erythrose, threose, erythrulose, arabinose, lyxose, ribose, xylose, ribulose, xylulose, allose, altrose, galactose, glucose, gulose, idose, mannose, talose, fructose, psicose, sorbose, tagatose, mannoheptulose, sedoheptulose, octolose, fucose, rhamnose, arabinose, sulose, sialose, and combinations thereof.

[0303] Other suitable non-SG sweeteners include mogroside IV, mogroside V, monk fruit, simonoside, monatin and its salts (monatin SS, RR, RS, SR), curculin, glycyrrhizic acid and its salts, thaumatin, monellin, mabinin, brazzein, hernandulcin, phylloside, phloridzin, phloridzin, trilobatin, baiyunoside, osladin, polypodoside A, pterocaryoside A, pterocaryoside B, mukurozioside, phlomisoside I, pericarp, and succinimidyl glycyrrhizin. andrin) I, abrusoside and cyclocarya paliurus glycoside I, sugar alcohols such as erythritol, sucralose, acesulfame acid and its salts, such as acesulfame potassium and acesulfame potassium; L-α-aspartyl-L-phenylalanine methyl ester (aspartame), N-[N-[3-(3-hydroxy-4-methoxyphenyl)isopropyl]-α-aspartyl]-L-phenylalanine methyl ester (saccharin (Advantame)), N-[N-[3-(3-hydroxy-4-methoxyphenyl)isopropyl]-α-aspartyl]-L-phenylalanine-1-methyl ester (ANS9801), alitame, saccharin and its salts, neohesperidin dihydrochalcone, cyclaminate, cyclamic acid and its salts, neotame, trehalose, raffinose, cellobiose, tagatose, DOLCIA PRIMA TM , allulose, inulin and combinations thereof.

[0304] The non-SG sweetener can be a caloric sweetener or a combination of caloric sweeteners. Caloric sweeteners include sucrose, fructose, glucose, high fructose corn / starch syrup, beet sugar, cane sugar, and combinations thereof.

[0305] In certain embodiments, the non-SG sweetener is a rare sugar selected from the group consisting of sorbitol, lyxose, ribulose, xylose, D-allose, L-ribose, D-tagatose, L-fucose, L-arabinose, solanose, and combinations thereof. The rare sugar is present in the sweetener composition in an amount of about 0.5 wt % to about 10.0 wt %, for example, about 0.5 wt % to about 2.5 wt %, about 0.5 wt % to about 2.0 wt %, about 0.5 wt % to about 1.5 wt %, about 0.5 wt % to about 1.0 wt %, about 1.0 wt % to about 3.0 wt %, about 1.0 wt % to about 2.5 wt %, about 1.0 wt % to about 2.0 wt %, about 1.0 wt % to about 1.5 wt %, about 2.0 wt % to about 3.0 wt %, about 2.0 wt % to about 2.5 wt %, about 2.0 wt % to about 4.0 wt %, about 4.0 wt % to about 6.0 wt %, about 6.0 wt % to about 8.0 wt %, or about 8.0 wt % to about 10.0 wt %.

[0306] The one or more non-SG sweeteners in the SG composition of the present application account for about 0.1wt% to about 50wt% of the SG composition, specifically, about 0.01wt%, about 0.02wt%, about 0.05wt%, about 0.07wt%, about 0.1wt%, about 0.2wt%, about 0.3wt%, about 0.4wt%, about 0.5wt%, about 0.6wt%, about 0.7wt%, about 0.8wt%, about 0.9wt%, about 1wt%, about 2wt%, about 3wt%, about 4wt%, about 5wt%, about 6wt%, about 7wt%, about 8wt%, about 9wt%, about 10wt%, about 11wt%, about 12wt%, about 13wt%, about 14wt%, about 15wt%, about 16wt%, about 17wt%, about 18wt%, about 19wt%, about 20wt%, about 21wt%, about 22wt%, about 23wt%, about 24wt%, about 25wt%, about 26wt%, about 27wt%, about 28wt%, about 29wt%, about 30wt%, about 31wt%, about 32wt%, about 33wt%, about 34wt%, about 35wt%, about 36wt%, about 37wt%, about 38wt%, about 39wt%, about 40wt%, about 41wt%, about 5wt%, about 16wt%, about 17wt%, about 18wt%, about 19wt%, about 20wt%, about 21wt%, about 22wt%, about 23wt%, about 24wt%, about 25wt%, about 26wt%, about 27wt%, about 28wt%, about 29wt%, about 30wt%, about 31wt%, about 32wt%, about 33wt%, about 34wt%, about 35wt%, about 36wt%, about 37wt%, about 38wt%, about 39wt%, about 40wt%, about 41wt%, about 42wt%, about 43wt%, about 44wt%, about 45wt%, about 46wt%, about 47wt%, about 48wt%, about 49wt%, about 50wt t%, about 51wt%, about 52wt%, about 53wt%, about 54wt%, about 55wt%, about 56wt%, about 57wt%, about 58wt%, about 59wt%, about 60wt%, about 61wt%, about 62wt%, about 63wt%, about 64wt%, about 65wt%, about 66wt%, about 67wt%, about 68wt%, about 69wt%, about 70wt%, about 71wt%, about 72wt%, about 73wt%, about 74wt%, about 75wt%, about 76wt%, about 77wt%, about 78wt%, about 79wt%, about 80wt% and all ranges therebetween such as about 0.01wt% to about 20wt%, about 0.03wt% to about 20wt%, about 0.05wt% to about 20wt%, about 0.07wt% to about 20wt%, about 0.1wt% to about 20wt%, about 0.3wt% to about 20wt%, about 0.5wt% to about 20wt%, about 0.7wt% to about 20wt%, about 1wt% to about 20wt%, about 3wt% to about 20wt%, about 5wt% to about 20wt%, about 7wt% to about 20wt%, about 10wt% to about 20wt%, about 15wt% to about 20wt%, about 0.01wt% to about 10wt%, about 0.03wt% to about 10wt%, about 0.05wt% to about 10wt%, about 0.07wt% to about 10wt%, about 0.1wt% to about 10wt%, about 0.3wt% to about 10wt%, about 0.5wt% to about 10wt%, about 0.7wt% to about 10wt%, about 1wt% to about 10wt%, about 3wt% to about 10wt%, about 5wt% to about 10wt%, about 7wt% to about 10wt%, about 0.01wt% to about 5wt%, about 0.03wt% to about 5wt%, about 0.05wt% to about 5wt%, about 0.07wt% to about 5wt%, about 0.1wt% to about 5wt%, about 0.3wt% to about 5wt%, about 0.5wt% to about 5wt%, about 0.7wt% to about 5wt%, about 1wt% to about 5wt%, about 3wt% to about 5wt%, about 0.01wt% to about 2.5wt%, about 0.03wt% to about 2.5wt%, about 0.05wt% to about 2.5wt%, about 0.07wt% to about 2.5wt%, about 0.1wt% to about 2.5wt%, about 0.3wt% to about 2.5wt%, about 0.5wt% to about 2.5wt%, about 0.7wt% to about 2.5wt%, about 1wt% to about 2.5wt%, about 5wt% to about 30wt%, about 10wt% to about 30wt%, about 20wt% to about 40wt%, or about 30wt% to about 50wt%. .

[0307] D.Additives

[0308] In other embodiments, the SG composition of the present application further comprises one or more additional additives selected from the following flavoring agents, salts, minerals, organic acids and inorganic acids, polyols, nucleotides, bitter compounds, astringent compounds, proteins or protein hydrolysates, surfactants, gums and waxes, antioxidants, polymers, fatty acids, vitamins, preservatives, hydrating agents and combinations thereof.

[0309] i. Flavoring agents

[0310] As used herein, "flavoring agent" refers to a compound or salt thereof which is acceptable for ingestion and which induces a flavor or taste in an animal or human. The flavoring agent may be natural, semi-synthetic or synthetic. Flavoring agents and flavoring component additives suitable for use in the SG composition of the present application include, but are not limited to, vanillin, vanillin extract, mango extract, cinnamon, citrus peel, coconut, ginger, chlorophyll, almond, laurel, thyme, cedar leaf, nutmeg, allspice, sage leaf, mace, menthol (including non-minty menthol), essential oils, such as oils derived from plants or fruits, such as peppermint oil, spearmint oil, other mint oils, clove oil, cinnamon oil, wintergreen oil or almond oil; plant extracts, fruit extracts, or fruit essences from grape skin, grape seed extract, apple, banana, watermelon, pear, peach, grape, strawberry, raspberry, cherry, plum, pineapple, apricot, citrus flavors such as extracts, essences, or lemon oil, lime, orange, tangerine, grapefruit, citron, kumquat and combinations thereof.

[0311] Non-limiting examples of specialty flavors include Dohler TM Natural flavor sweetener K14323 (Dohler TM , Darmstadt, Germany), Symrise TM Natural flavor masking sweeteners 161453 and 164126 (Symrise TM , Holzminden, Germany), Natural Advantage TM Bitter Blockers 1, 2, 9 and 10 (Natural Advantage TM , indefinitely, New Jersey, USA) and Sucramask TM (Creative Development Manager, Stockton, California, USA).

[0312] In some embodiments, the flavoring agent is present in the SG composition of the present application at a concentration of about 0.1 ppm to about 4000 ppm.

[0313] ii. Salt

[0314] The SG composition of the present application may contain one or more salts. The salt may be an organic salt or an inorganic salt. The term "salt" as used herein refers to a salt that retains the chemical activity required by the SG composition of the present application and is safe for humans or animals within a generally acceptable range.

[0315] In some embodiments, the one or more salts are salts formed by metal cations such as calcium, bismuth, barium, magnesium, aluminum, copper, cobalt, nickel, cadmium, sodium, potassium, etc., or salts formed by cations formed by ammonia, N,N-dibenzylethylenediamine, D-glucamine, ethanolamine, diethanolamine, triethanolamine, N-methylglucamine tetraethylammonium, or ethylenediamine.

[0316] In some embodiments, one or more salts are formed from inorganic acids such as hydrochloric acid, hydrobromic acid, sulfuric acid, nitric acid, phosphoric acid, and the like, or from organic acids such as acetic acid, propionic acid, hexanoic acid, 3-cyclopentylpropionic acid, glycolic acid, pyruvic acid, lactic acid, malonic acid, succinic acid, malic acid, maleic acid, fumaric acid, tartaric acid, citric acid, benzoic acid, 3-(4-hydroxybenzoyl)benzoic acid, cinnamic acid, mandelic acid, methanesulfonic acid, ethanesulfonic acid, 1,2-ethyl-disulfonic acid, isethionic acid, benzenesulfonic acid, 4-chlorobenzenesulfonic acid, 2-naphthalenesulfonic acid, methyl 4-toluenesulfonate, camphorsulfonic acid, 4-methylbicyclo[2.2.2]-oct-2-ene-1-carboxylic acid, glucoheptonic acid, 3-phenylpropionic acid, trimethylacetic acid, tert-butylacetic acid, dodecylsulfuric acid, gluconic acid, glutamic acid, hydroxynaphthalene, salicylic acid, stearic acid, and succinic acid.

[0317] In a specific embodiment, inorganic salts include, but are not limited to, sodium chloride, sodium carbonate, sodium bicarbonate, sodium acetate, sodium sulfide, sodium sulfate, sodium phosphate, potassium chloride, potassium citrate, potassium carbonate, potassium bicarbonate, potassium acetate, europium chloride (EuCl3), gadolinium chloride (GdCl3), terbium chloride (TbCl3), magnesium sulfate, magnesium chloride, mono-, di-, tri-basic sodium or potassium salts of phosphoric acid (such as inorganic phosphates), salts of hydrochloric acid (such as inorganic chlorides), sodium carbonate, sodium bisulfate and sodium bicarbonate. Suitable organic salts include, but are not limited to, choline chloride, sodium alginate (sodium alginate), sodium glucoheptonic acid, sodium gluconate (sodium gluconate), potassium gluconate (potassium gluconate), guanidine HCl, glucosamine HCl, amiloride HCl, monosodium glutamate (MSG), sodium adenosine monophosphate, magnesium gluconate, potassium tartrate (monohydrate) and sodium tartrate (dihydrate).

[0318] In certain embodiments, the salt is a metal or alkali metal halide, a metal or alkali metal carbonate or bicarbonate, or a metal or alkali metal phosphate, hydrogen phosphate, pyrophosphate, triphosphate, metaphosphate or pyrosulfite. In certain specific embodiments, the salt is an inorganic salt comprising sodium, potassium, calcium or magnesium. In certain embodiments, the salt is a sodium salt or a potassium salt.

[0319] The salt forms may be added to the sweetener composition in the same amount as their acid or base forms.

[0320] The salts for selection include various chlorides or sulfates, such as sodium chloride, potassium chloride, magnesium chloride, sodium sulfate, magnesium sulfate, and potassium sulfate, or edible salts. In some embodiments, the one or more salts include one or more SG salts. In some further embodiments, the one or more SG salts include one or more salts of RB and / or STB.

[0321] In some embodiments, the one or more salts comprise one or more amino acid salts. In some embodiments, the one or more salts comprise one or more polyamino acid salts.

[0322] In some embodiments, the one or more salts comprise one or more sugar acid salts.

[0323] The one or more salts may account for about 0.01 wt.% to about 30 wt.% of the SG composition, specifically, about 0.01 wt.%, about 0.02 wt.%, about 0.03 wt.%, about 0.04 wt.%, about 0.05 wt.%, about 0.06 wt.%, about 0.07 wt.%, about 0.08 wt.%, about 0.09 wt.%, 0.1 wt.%, about 0.2 wt.%, about 0.3 wt.%, about 0.4 wt.%, about 0.5 wt.%, about 0.6 wt.%, about 0.7 wt.%, about 0.8 wt.%, about 0.9 wt.%, about 1 wt.%, about 2 wt.%, about 3 wt.%, about 4 wt.%, about 6 wt.%, about 7 wt.%, about 8 wt.%, about 9 wt.%, about 10 wt%, about 11wt%, about 12wt%, about 13wt%, about 14wt%, about 15wt%, about 16wt%, about 17wt%, about 18wt%, about 19wt%, about 20wt%, about 21wt%, about 22wt%, about 23wt%, about 24wt%, about 25wt%, about 26wt%, about 27wt%, about 28wt%, about 29wt%, about 30wt%, about 31wt%, about 32wt%, about 33wt%, about 34wt%, about 35wt%, about 36wt%, about 37wt%, about 38wt%, about 39wt%, about 40wt%, about 41wt%, about 42wt%, about 43wt%, about 44wt%, about 45wt%, About 46wt%, about 47wt%, about 48wt%, about 49wt%, about 50wt% and all ranges therebetween, including, for example, about 0.01wt% to about 10wt%, about 0.03wt% to about 10wt%, about 0.05wt% to about 10wt%, about 0.07wt% to about 10wt%, about 0.1wt% to about 10wt%, about 0.3wt% to about 10wt%, about 0.5wt% to about 10wt%, about 0.7wt% to about 10wt%, about 1wt% to about 10wt%, about 3wt% to about 10wt%, about 5wt% to about 10wt%, about 7wt% to about 10wt%, about 0.01wt% to about 3wt%, about 0.03wt% to about 10wt%, About 3wt%, about 0.05wt% to about 3wt%, about 0.07wt% to about 3wt%, about 0.1wt% to about 3wt%, about 0.3wt% to about 3wt%, about 0.5wt% to about 3wt%, about 0.7wt% to about 3wt%, about 1wt% to about 3wt%, about 0.01wt% to about 1wt%, about 0.03wt% to about 1wt%, about 0.05wt% to about 1wt%, about 0.07wt% to about 1wt%, about 0.1wt% to about 1wt%, about 0.3wt% to about 1wt%, about 0.5wt% to about 1wt%, about 0.7wt% to about 1wt%, about 0.01wt% to about 0.3wt%, about 0.03wt% to about 0.3wt%, about 0.05wt% to about 0.3wt%, about 0.07wt% to about 0.3wt%, about 0.1wt% to about 0.3wt%, about 0.01wt% to about 0.1wt%, about 0.03wt% to about 0.1wt%, about 0.05wt% to about 0.1wt%, about 0.07wt% to about 0.1wt%, about 0.01wt% to about 0.03wt%, about 0.01wt% to about 0.05wt%, about 0.01wt% to about 0.07wt%, about 5wt% to about 30wt%, about 10wt% to about 30wt%, or about 20wt% to about 30wt%. .

[0324] No matter what salt is used in the composition of the present application, the content of salt in the composition is calculated based on sodium chloride. More specifically, the total ash content of the sample can be measured using the general method for measuring total ash content described in FAO JECFA MONOGRAPHS (2007 Vol. 4) to determine the salt content (based on the weight of NaCl). The weight of sodium oxide is multiplied by 1.89 to determine the weight of sodium chloride. For example, if the total ash amount of 100g of the composition of the present application is 1g, the salt content of the composition of the present application is 1.89wt%.

[0325] ⅲ. Minerals

[0326] According to the teachings of the present application, minerals include inorganic chemical elements required by living organisms. Minerals include a wide range of compositions (such as elements, simple salts and complex silicates), and their crystalline structures also vary greatly. They can be naturally present in foods and beverages, can be added as supplements, and can also be consumed or distributed separately through foods or beverages.

[0327] Minerals can be classified as macrominerals, which are required in larger amounts, or trace minerals, which are required in smaller amounts. Macrominerals are generally required in amounts greater than or equal to about 100 mg per day, while trace minerals are generally required in amounts less than about 100 mg per day.

[0328] In a specific embodiment of the present application, mineral substances are selected from macrominerals, trace minerals or their combinations. Non-limiting examples of macrominerals include calcium, chlorine, magnesium, phosphorus, potassium, sodium and sulfur. Non-limiting examples of trace minerals include chromium, cobalt, copper, fluorine, iron, manganese, molybdenum, selenium, zinc and iodine. Although iodine is classified in trace minerals, its requirement is larger than other trace minerals and is often classified in the category of macrominerals.

[0329] In certain specific embodiments, the mineral is a trace mineral considered essential for human nutrition, non-limiting examples of which include bismuth, boron, lithium, nickel, rubidium, silicon, strontium, tellurium, tin, titanium, tungsten, and vanadium.

[0330] The minerals used in this application can be in any form known to those of ordinary skill in the art. For example, in a specific embodiment, the mineral is in its ionic form, with a positive or negative charge. In other specific embodiments, the mineral exists in its molecular form. For example, sulfur and phosphorus usually exist in the form of sulfates, sulfides and phosphates in nature.

[0331] ⅳ. Organic and inorganic acids

[0332] Suitable organic acid additives include any compound containing -COOH part, for example, C2-C30 carboxylic acid, substituted hydroxy C2-C30 carboxylic acid, butyric acid (ethyl ester), substituted butyric acid (ethyl ester), benzoic acid, substituted benzoic acid (such as 2,4-dihydroxybenzoic acid), substituted cinnamic acid, oxyacid, substituted hydroxybenzoic acid, anisic acid substituted cyclohexyl carboxylic acid, tannic acid, aconitic acid, lactic acid, tartaric acid, citric acid, isocitric acid, gluconic acid, glucoheptonic acid, adipic acid, hydroxycitric acid, malic acid, fruitaric acid (a mixture of malic acid, fumaric acid and tartaric acid), fumaric acid, maleic acid, succinic acid, chlorogenic acid, salicylic acid, creatine, caffeic acid, bile acid, acetic acid, ascorbic acid, alginic acid, isoascorbic acid, polyglutamic acid, glucono-δ-lactone, and alkali metal or alkaline earth metal salt derivatives thereof. In addition, the organic acid additive can also be a left-handed or right-handed structure.

[0333] The examples of these described organic acids can be optionally substituted by at least one group selected from the following groups: hydrogen, alkyl, alkenyl, alkynyl, halogen, halogen alkyl, carboxyl, acyl, acyloxy, amino, amine, carboxyl derivatives, alkylamino, dialkylamino, arylamino, alkoxy, aryloxy, nitro, cyano, sulfo, thiol, imine, sulfonyl, oxysulfide, sulfinyl, sulfamoyl, alkoxycarbonyl, carbamoyl, phosphonyl, phosphinyl, phosphoryl, phosphino, thioester, thioether, anhydride, oxime, hydrazine, carbamyl, phosphorus or phosphonato. In a specific embodiment, when present in an oral consumable composition such as a beverage, the effective amount of the organic acid additive present in the sweetener composition is to provide a concentration of about 10ppm to about 5000ppm.

[0334] Organic acids also include amino acids, such as aspartic acid, arginine, glycine, glutamic acid, proline, threonine, theanine, cysteine, cystine, alanine, valine, tyrosine, leucine, arabinose, trans-4-hydroxyproline, isoleucine, asparagine, serine, lysine, histidine, ornithine, methionine, carnitine, aminobutyric acid (α-, β-, and / or δ-isomers), glutamine, hydroxyproline, taurine, norvaline and sarcosine. Amino acids can be left-handed or right-handed structures, and can also be single, two or three forms of the same or different amino acids. In addition, amino acids can be α-, β-, γ- and / or δ-isomers as needed. In some embodiments, the combination of the above-mentioned amino acids and their corresponding salts (e.g., sodium, potassium, calcium, magnesium salts or other alkali metal or alkaline earth metal salts, or acid salts) is also a suitable additive. Amino acids can be natural or synthetic. Amino acids can also be modified. Modified amino acids refer to any amino acid (e.g., N-alkyl amino acids, N-acyl or N-methyl amino acids) or a combination thereof in which at least one atom is added, removed or substituted. Non-limiting examples of modified amino acids include amino acid derivatives such as trimethylglycine, N-methyl-glycine and N-methyl-alanine. Modified amino acids in the present application include modified and unmodified amino acids.

[0335] As used herein, amino acids also include peptides and polypeptides (such as dipeptides, tripeptides, tetrapeptides and pentapeptides), for example, glutathione and L-alanyl-L-glutamine. Suitable polyamino acid additives include poly-L-aspartic acid, poly-L-lysine (such as poly-La-lysine or poly-Ls-lysine), poly-L-ornithine (such as poly-La-ornithine or poly-Ls-ornithine), poly-L-arginine, other polymer forms of amino acids, and salt forms thereof (such as calcium, potassium, sodium or magnesium salts, such as L-glutamic acid monosodium salt). Polyamino acid additives can also be left-handed or right-handed structures. In addition, polyamino acids can be α-, β-, γ-, δ- and ε-isomers as needed. In some embodiments, the combination of the above-mentioned polyamino acids and their corresponding salts (for example, sodium, potassium, calcium, magnesium salts or other alkali metal or alkaline earth metal salts, or acid salts) is also a suitable additive. The polyamino acids described in the present application can also include copolymers of different amino acids. The polyamino acids can be natural or synthetic. The polyamino acid can also be modified. At least one atom is added, removed or replaced or a combination thereof (e.g., N-alkyl polyamino acid or N-acyl polyamino acid). The polyamino acid in the present application includes modified and unmodified amino acids. For example, modified polyamino acids include but are not limited to polyamino acids of various molecular weights (MW) such as poly-La-lysine with a MW of 1500, 6000, 25200, 63000, 83000, or 300000.

[0336] In a specific embodiment, the amino acid additive is present in the SG composition in an effective amount to provide a concentration of about 10 ppm to about 50,000 ppm when present in an oral consumable composition such as a beverage. In another embodiment, the amino acid additive is present in the SG composition in an effective amount to provide a concentration of about 1000 ppm to about 10,000 ppm, about 2,500 ppm to about 5000 ppm, or about 250 ppm to about 7500 ppm when present in an oral consumable composition such as a beverage.

[0337] Suitable inorganic acid additives include, but are not limited to, phosphoric acid, phosphorous acid, polyphosphoric acid, hydrochloric acid, sulfuric acid, carbonic acid, sodium dihydrogen phosphate, and alkali metal or alkaline earth metal salts thereof (eg, Mg / Ca salts of phytic acid).

[0338] When present in an orally consumable composition such as a beverage, the inorganic acid additive is present in the sweetener composition in an amount effective to provide a concentration of from about 25 ppm to about 25,000 ppm.

[0339] ⅴ. Polyols

[0340] The term "polyol" as used herein refers to a molecule containing more than one hydroxyl group. Polyols can be diols, triols and tetraols containing 2, 3 and 4 hydroxyls, respectively. Polyols can also contain more than 4 hydroxyls, for example, pentahydric alcohols, hexahydric alcohols and heptahydric alcohols, etc. containing 5, 6 and 7 hydroxyls, respectively. In addition, polyols can also be reduced forms of carbohydrates, wherein the carbonyl (aldehyde or ketone, reducing sugar) is reduced to primary or secondary hydroxyls, can be sugar alcohols, polyhydric alcohols or polyols.

[0341] In some embodiments, non-limiting examples of polyols include maltitol, mannitol, sorbitol, lactitol, xylitol, isomalt, propylene glycol, glycerol (glycerine), threitol, dulcitol, isomerized sucrose, reduced isomaltose oligosaccharides, reduced xylo-oligosaccharides, reduced gentio-oligosaccharides, reduced maltose syrup, reduced glucose syrup and sugar alcohols, or any other carbohydrate that can be reduced without negatively affecting the taste.

[0342] In certain embodiments, the polyol is present in the SG composition in an amount effective to provide a concentration of about 100 ppm to about 250,000 ppm when present in an oral consumable composition such as a beverage. In other embodiments, the polyol is present in the SG composition in an amount effective to provide a concentration of about 400 ppm to about 80,000 ppm, about 5,000 ppm to about 40,000 ppm when present in an oral consumable composition such as a beverage.

[0343] ⅵ. Nucleotides

[0344] Suitable nucleotide additives include, but are not limited to, inosine monophosphate ("IMP"), guanosine monophosphate ("GMP"), adenosine monophosphate ("AMP"), cytosine monophosphate (CMP), uracil monophosphate (UMP) i, inosine diphosphate, glycoside diphosphate, adenosine diphosphate, cytosine diphosphate, uracil diphosphate, inosine triphosphate, guanosine triphosphate, adenosine triphosphate, cytosine triphosphate, uracil triphosphate, alkali metal or alkaline earth metal salts thereof, and combinations thereof. The nucleotides described herein may also include nucleotide-related derivatives, such as nucleotides or nucleic acid bases (e.g., guanine, cytosine, adenine, thymine, uracil).

[0345] When present in an orally consumable composition such as a beverage, the nucleotides are present in the SG composition in an amount effective to provide a concentration of about 5 ppm to about 1000 ppm.

[0346] ⅶ Bitter compounds

[0347] Suitable bitter compound additives include, but are not limited to, caffeine, quinine, urea, bitter orange oil, naringin, quassia and their salts.

[0348] When present in a consumable product such as a beverage, the bitter compound is present in the sweet composition in an amount effective to provide a concentration of from about 25 ppm to about 25,000 ppm.

[0349] ⅷ. Astringent compounds

[0350] Suitable astringent compound additives include, but are not limited to, tannic acid, europium chloride (EuCl3), gadolinium chloride (GdCl3), terbium chloride (TbCl3), alum, tannic acid, and polyphenols (e.g., tea polyphenols). When present in a consumable product such as a beverage, the astringent additive is present in the sweetening composition in an amount effective to provide a concentration of about 10 ppm to about 5000 ppm.

[0351] ⅸ Protein or protein hydrolysate

[0352] Suitable protein or protein hydrolysate additives include, but are not limited to, bovine serum albumin (BSA), whey protein (including ratios or concentrations thereof such as 90% instant whey protein isolate, 34% whey protein, 50%> hydrolyzed whey protein and 80%> whey protein concentrate), soluble rice protein, soy protein, protein isolate, protein hydrolysate, reaction products of protein hydrolysate, glycoprotein and / or proteoglycans containing amino acids (e.g., glycine, alanine, serine, threonine, asparagine, glutamine, arginine, valine, isoleucine, leucine, norvaline, methionine, proline, tyrosine, hydroxyproline, etc.), collagen (e.g., gelatin), partially hydrolyzed collagen (e.g., hydrolyzed fish collagen) and collagen hydrolysate (e.g., porcine collagen hydrolysate).

[0353] When present in a consumable product such as a beverage, the protein hydrolysate is present in the sweetening composition in an amount effective to provide a concentration of from about 200 ppm to about 50,000 ppm.

[0354] ⅹ. Surfactants

[0355] Suitable surfactant additives include, but are not limited to, polysorbates (e.g., polyoxyethylene sorbitan monooleate (Tween 80), Tween 20, Tween 60), sodium dodecylbenzenesulfonate, dioctyl sulfosuccinate or sodium octyl sulfosuccinate, sodium dodecylsulfonate, cetylpyridinium chloride, cetylmethylammonium bromide, sodium cholate, carbamoyl, choline chloride, sodium glycocholate, sodium taurodeoxycholate, arginine laurate, sodium stearoyl lactylate, sodium taurocholate, lecithin, sucrose oleate, sucrose stearate, sucrose palmitate, sucrose laurate, and other emulsifiers.

[0356] When present in an orally consumable composition such as a beverage, the surfactant additive is present in the SG composition in an amount effective to provide a concentration of from about 30 ppm to about 2000 ppm.

[0357] xi. Gums and waxes

[0358] Gums and mucilages represent a wide range of different branched chain structures. Guar gum is a galactomannan produced from the ground endosperm of guar seeds. Guar gum is commercially available (e.g., Benefiber from Novartis AG). Other gums such as gum arabic and pectin also have different structures. Other gums include xanthan gum, gellan gum, tara gum, linseed gum, and locust bean gum.

[0359] Waxes are esters of ethylene glycol and two fatty acids and are generally hydrophobic liquids that are insoluble in water.

[0360] xii. Antioxidants

[0361] As used herein, "antioxidant" refers to any substance that can hinder, inhibit or reduce oxidative damage to cells and biomolecules. Without wishing to be bound by theory, it is believed that antioxidants can hinder, inhibit or reduce oxidative damage to cells and biomolecules by stabilizing free radicals before they can react to cause damage. Likewise, antioxidants can prevent or delay the onset of some degenerative diseases.

[0362] Examples of antioxidants suitable for use in embodiments of the present application include, but are not limited to, vitamins, vitamin coenzymes, minerals, hormones, carotenoids, carotenoid terpenoids, non-carotenoid terpenoids, flavonoids, flavonoid polyphenols (e.g., bioflavonoids), flavonols, flavones, phenols, polyphenols, phenolic esters, polyphenolic esters, non-flavonoid phenolic aldehydes, isothiocyanates, and combinations thereof. In some embodiments, the antioxidant is vitamin A, vitamin C, vitamin E, ubiquinone, mineral selenium, manganese, melatonin, alpha-carotene, beta-carotene, tomato, lutein, zeaxanthin, cryptoxanthin, resveratrol, eugenol, quercetin, catechins, gossypol, quercetin, curcumin, ferulic acid, thymol, hydroxytyrosol, turmeric, thyme, olive oil, lipoic acid, glutathione, glutamine, oxalic acid, tocopherol-derived compounds, butylated hydroxytoluene (BHA), butylated hydroxytoluene (BHT), ethylenediaminetetraacetic acid (EDTA), tert-butylhydroquinone, acetic acid, pectin, tocotriene Phenols, tocopherols, coenzyme Q10, zeaxanthin, astaxanthin, canthaxanthin, saponins, limonoids, kanfeilan, myricetin, isorhamnetin, proanthocyanidins, quercetin, rutin, digitonin, apigenin, citrus flavonoids, quercetin, citrus flavonoids, eriodictyol, flavan-3-ols (such as anthocyanidins), catechin, epicatechin and its gallic acid form, epigallocatechin and its gallic acid form (ECGC), theaflavins and its gallic acid form, thearubigins, isoflavones, phytoestrogens, genistein, soy jasmine, glycitein, anthocyanidins, anthocyanidins, delphinidin, malvaccin, pelargonium color , methyl anthocyanidin, petroselinic acid, ellagic acid, salicylic acid, rosmarinic acid, cinnamic acid and its derivatives (such as ferulic acid), chlorogenic acid, chicoric acid, tannin, ellagitannins, anthocyanins, beta-anthocyanidins and other plant pigments, silymarin, citric acid, lignans, antinutrients, bilirubin, uric acid, Ra-. lipoic acid, N-acetylcysteine, emblica fruit extract, apple extract, apple peel extract (apple polyphenols), South African black tea extract, South African green tea extract, hawthorn extract, red berry extract, green coffee antioxidant (GCA), wild cherry enzyme extract 20%, grape seed extract (VinO seed), cocoa extract, hops extract, mangosteen extract, mangosteen shell extract, cranberry extract, pomegranate extract, pomegranate shell extract, pomegranate seed extract, hawthorn extract, pomella pomegranate extract, cinnamon bark extract, grape skin extract, bilberry extract, pine bark extract, pycnogenol, elderberry extract, mulberry root extract, wolfberry extract, blackberry extract, blueberry extract, blueberry leaf extract, raspberry extract, turmeric extract, citrus aurantium flavone, black currant polyphenols, ginger, acai powder, green coffee bean extract, green tea extract and phytic acid, or a combination thereof. In an alternative embodiment, the antioxidant is a synthetic antioxidant such as butylated hydroxytoluene or butylated hydroxyanisole.Other sources of antioxidants suitable for use in embodiments of the present application include, but are not limited to, fruits, vegetables, tea, cocoa, chocolate, vanilla, flavorings, rice, organic meat from livestock, yeast, whole wheat or cereals.

[0363] Specific antioxidants that belong to the class of phytonutrients are called polyphenols (also called "polyphenol crude extracts"), which are a group of chemicals found in plants and are characterized by having more than one phenol group in a molecule. Polyphenols can provide a variety of health benefits, including protection against cancer, heart disease and chronic inflammation, as well as improved mental and physical strength. Polyphenols suitable for use in embodiments of the present application include catechols, proanthocyanidins, proanthocyanidins, anthocyanins, quercetin, rutin, resveratrol, isoflavones, curcumin, punicalagin, ellagitannins, hesperidin, naringin, citrus flavonoids, chlorogenic acid, other similar substances, and combinations thereof.

[0364] In a specific embodiment, the antioxidant is a catechol, such as epigallocatechin gallate (EGCG). Sources of catechol suitable for use in embodiments of the present application include, but are not limited to, green tea, white tea, black tea, oolong tea, chocolate, cocoa, red wine, grape seeds, red grape skin, purple grape skin, red grape juice, purple grape juice, berries, pycnogenol, and red apple peel.

[0365] In some embodiments, the antioxidant is selected from proanthocyanidins, proanthocyanidins, or a combination thereof. Sources of proanthocyanidins and proanthocyanidins suitable for use in embodiments of the present application include, but are not limited to, red grapes, purple grapes, cocoa, chocolate, grape seeds, red wine, cocoa beans, cranberries, apple peels, plums, blueberries, black currants, aronia berries, green tea, sorghum, Ceylon cinnamon, barley, red kidney beans, pinto beans, humulus, almonds, hazelnuts, pecans, pistachios, pycnogenol, and berries of various colors.

[0366] In a particular embodiment, the antioxidant is anthocyanin. Sources of anthocyanins suitable for use in embodiments of the present application include, but are not limited to, red raspberries, blueberries, lingonberries, cranberries, raspberries, cherries, pomegranates, strawberries, elderberries, aronia berries, red grape skins, purple grape skins, grape seeds, red wine, black currants, red currants, cocoa, plums, apple skins, peaches, red pears, red cabbage, red onions, red oranges, and blackberries.

[0367] In some embodiments, the antioxidant is selected from quercetin, rutin or a combination thereof. Sources of quercetin and rutin suitable for use in embodiments of the present application include, but are not limited to, red apples, onions, kale, blueberries, lingonberries, arononia bitters, cranberries, blackberries, blueberries, strawberries, raspberries, blackcurrants, green tea, black tea, plums, apricots, parsley, leeks, broccoli, red peppers, berry wine and ginkgo.

[0368] In some embodiments, the antioxidant is resveratrol. Sources of resveratrol suitable for use in the embodiments of the present application include, but are not limited to, red grapes, peanuts, cranberries, blueberries, lingonberries, mulberries, Japanese Itatori tea, and red wine.

[0369] In a particular embodiment, the antioxidant is isoflavone. Sources of isoflavone suitable for use in embodiments of the present application include, but are not limited to, soybeans, soy products, legumes, alfalfa sprouts, chickpeas, peanuts, and red clover.

[0370] In some embodiments, the antioxidant is curcumin. Sources of curcumin suitable for use in embodiments of the present application include, but are not limited to, turmeric and mustard.

[0371] In a particular embodiment, the antioxidant is selected from punicalagin, ellagitannin or a combination thereof. Sources of punicalagin and ellagitannin suitable for use in the present application embodiment include, but are not limited to, pomegranate, raspberry, strawberry, walnut and oak barrel aged red wine.

[0372] In some embodiments, the antioxidant is a citrus flavonoid, such as hesperidin or naringin. Sources of citrus flavonoids such as hesperidin or naringin suitable for use in embodiments of the present application include, but are not limited to, oranges, grapefruits, and citrus juice.

[0373] In a particular embodiment, the antioxidant is chlorogenic acid. Sources of chlorogenic acid suitable for use in embodiments of the present application include, but are not limited to, green coffee, holly tea, red wine, grape seeds, red grape skins, purple grape skins, red grape juice, purple grape juice, apple juice, cranberries, pomegranates, blueberries, strawberries, sunflowers, Echinacea, Pycnogenol, and apple peels.

[0374] xiii.Polymer

[0375] Suitable polymer additives include, but are not limited to, chitosan, pectin, mucilage, pectic acid, polysaccharide acid, polygalacturonic acid, starch, food hydrocolloids or crude extracts thereof (e.g., Fibergum senegalense gum). TM ), acacia gum, carrageenan), poly-L-lysine (such as poly-L-α-lysine or poly-L-ε-lysine), poly-L-ornithine (such as poly-L-α-ornithine or poly-L-ε-ornithine), polypropylene glycol, polyethylene glycol, poly (ethylene glycol methyl ether), polyarginine, polyaspartic acid, polyglutamic acid, polyethyleneimine, alginic acid, sodium alginate, propylene glycol alginate, and sodium alginate, sodium hexametaphosphate and its salts, and other cationic polymers and anionic polymers.

[0376] When present in an orally consumable composition such as a beverage, the polymer is present in the sweetener composition in an amount effective to provide a concentration of about 30 ppm to about 2000 ppm.

[0377] xiv. Fatty acids

[0378] The term "fatty acid" is used herein to refer to any straight-chain monocarboxylic acid, including saturated fatty acids, unsaturated fatty acids, long-chain fatty acids, medium-chain fatty acids, short-chain fatty acids, fatty acid precursors (including omega-9 fatty acid precursors), and esterified fatty acids. The term "long-chain polyunsaturated fatty acid" is used herein to refer to any polyunsaturated carboxylic acid or organic acid having a long fatty chain. The term "omega-3 fatty acid" is used herein to refer to any polyunsaturated fatty acid having a first double bond as the third carbon-carbon bond from the methyl group at the end of its carbon chain. In a particular embodiment, omega-3 fatty acids may include long-chain omega-3 fatty acids. The term "omega-6 fatty acid" is used herein to refer to any polyunsaturated fatty acid having a first double bond as the sixth carbon-carbon bond from the methyl group at the end of its carbon chain.

[0379] Omega-3 fatty acids suitable for use in embodiments of the present application can be produced, for example, from algae, fish, animals, plants, or combinations thereof. Examples of suitable omega-3 fatty acids include, but are not limited to, linolenic acid, alpha-linolenic acid, eicosapentaenoic acid, docosahexaenoic acid, octadecatetraenoic acid, eicosatetraenoic acid, and combinations thereof. In some embodiments, suitable omega-3 fatty acids can be provided in fish oils (e.g., herring oil, tuna oil, salmon oil, bonito oil, and cod oil), microalgae omega-3 oils, or combinations thereof. In particular embodiments, suitable omega-3 fatty acids can be produced from commercially available omega-3 fatty acid oils, such as: Microalgae DHA oil (available from Martek, Columbia, MD), OmegaPure (available from OmegaProtein, Houston, TX), Marinol C-38 (available from LipidNutrition, Channahon, IL), Bonito oil and MEG-3 (available from OceanNutrition, Dartmouth, NS), Evogel (available from Symrise, Holzminden, Germany), Marine Oil produced from tuna or salmon (available from Arista Wilton, CT), OmegaSource 2000, Marine Oil produced from herring, and Marine Oil produced from cod (available from OmegaSource, RTP, NC).

[0380] Examples of suitable omega-6 fatty acids include, but are not limited to, linoleic acid, gamma-linolenic acid, dihomo-gamma-linolenic acid, eicosatetraenoic acid, eicosadienoic acid, docosadienoic acid, adrenic acid, herringic acid, and combinations thereof.

[0381] Esterified fatty acids suitable for use in the embodiments of the present application include, but are not limited to, monoglycerides containing omega-3 and / or omega-6 fatty acids, diglycerides containing omega-3 and / or omega-6 fatty acids, triglycerides containing omega-3 and / or omega-6 fatty acids, and combinations thereof.

[0382] xv. Vitamins

[0383] Vitamins are small amounts of organic compounds that the human body needs to maintain normal function. When the human body uses vitamins, it does not need to be broken down like other nutrients such as carbohydrates and proteins. Thirteen vitamins have been identified, and one or more of them can be used in the composition of the present application. Suitable vitamins and their alternative chemical names followed by parentheses include: vitamin A (rosin oil, retinal), vitamin D (calciferol, cholecalciferol, lecithin, ergocalciferol, dihydrotachysterol, 7-dehydrocholesterol), vitamin E (tocopherol, tocotrienol), vitamin K (phylloquinone, naphthoquinone), vitamin B1 (thiamine), vitamin B2 (riboflavin, vitamin G), vitamin B3 (niacin, anti-black tongue factor, vitamin PP), vitamin B5 (pantothenic acid), vitamin B6 (pyridoxine, pyridoxal, pyridoxamine), vitamin B7 (biotin, vitamin H), vitamin B9 (folic acid, folate, folic acid analogs, vitamin M, pteroyl-L-glutamic acid), vitamin B12 (cobalamin, cyanocobalamin) and vitamin C (ascorbic acid).

[0384] Other different compounds are also classified as vitamins by experts. These compounds can be called pseudovitamins, which include but are not limited to compounds such as ubiquinone (coenzyme Q10), pancreatic acid, dimethylglycine, taestrile, amygdalin, flavonoids, p-aminobenzoic acid, adenine, adenylic acid and s-methylmethionine. The term vitamin used in this application includes pseudovitamins.

[0385] In some embodiments, the vitamin is a fat-soluble vitamin selected from vitamin A, D, E, K, and combinations thereof. In other embodiments, the vitamin is a water-soluble vitamin selected from vitamin Bl, vitamin B2, vitamin B3, vitamin B6, vitamin B12, folic acid, biotin, pantothenic acid, vitamin C, and combinations thereof.

[0386] xvi. Preservatives

[0387] In some embodiments of the present application, the preservative is selected from a bactericide, an anti-enzyme, or a combination thereof. Non-limiting examples of bactericides include sulfites, propionates, benzoates, sorbates, nitrates, nitrites, bacteriocins such as nisin, salts, sugars, acetic acid, dimethyl dicarbonate (DMDC), ethanol, and ozone.

[0388] According to a specific embodiment, the preservative is a sulfite. Sulfites include but are not limited to sulfur dioxide, sodium bisulfite and potassium bisulfite.

[0389] Still according to a specific embodiment, the preservative is a propionate. Propionates include but are not limited to propionic acid, calcium propionate and sodium propionate.

[0390] According to still another specific embodiment, the preservative is a benzoate. Benzoate includes but is not limited to sodium benzoate and benzoic acid.

[0391] In another specific embodiment, the preservative is a sorbate. Sorbic acid salts include but are not limited to potassium sorbate, sodium sorbate, calcium sorbate and sorbic acid.

[0392] In still another specific embodiment, the preservative is a nitrate and / or a nitrite. Nitrates and nitrites include but are not limited to sodium nitrate and sodium nitrite.

[0393] In yet still another specific embodiment, the at least one preservative is a bacteriocin, such as nisin.

[0394] In another specific embodiment, the preservative is ethanol or ozone.

[0395] Non-limiting examples of antibiotics suitable for use in particular embodiments of the present application include ascorbic acid, citric acid, and metal chelators such as ethylenediaminetetraacetic acid (EDTA).

[0396] xvii. Hydration Agents

[0397] Hydration products help replace fluids that the body loses through excretion. For example, fluids are excreted as sweat to regulate body temperature, as urine to remove waste products, and as water vapor to exchange gases in the lungs. Fluid loss can also occur from many external causes, non-limiting examples of which include physical exercise, exposure to dry air, diarrhea, vomiting, high fever, shivering, bleeding, and low blood pressure. Disease conditions that cause fluid loss include diabetes, cholera, gastroenteritis, bacillary dysentery, and yellow fever. Nutritional disorders that cause fluid loss include excessive electrolyte depletion, imbalances, fasting, and diffuse weight loss.

[0398] In a specific embodiment, the hydration product is a composition that helps the body replenish lost fluid during exercise. Therefore, in a specific embodiment, the hydration product is an electrolyte, and its non-limiting examples include sodium, potassium, calcium, magnesium, chloride, phosphate, bicarbonate and its combination. Electrolytes suitable for some embodiments of the present application are also described in U.S. Patent No. 5,681,569, which is incorporated herein by reference. In some embodiments, electrolytes are obtained from their corresponding water-soluble salts. Non-limiting examples of salts suitable for some embodiments include chlorides, carbonates, sulfates, acetates, bicarbonates, citrates, phosphates, hydrogen phosphates, tartrates, sorbates, benzoates or their combinations. In other embodiments, electrolytes are provided by fruit juice, fruit extracts, vegetable extracts, tea or tea extracts.

[0399] In a specific embodiment of the present invention, the hydrated product is a carbohydrate to supplement the energy storage burned by the muscles. Suitable carbohydrates used in a specific embodiment of the present invention are described in U.S. Patent Nos. 4,312,856, 4,853,237, 5,681,569 and 6,989,171, which are incorporated herein by reference. Non-limiting examples of suitable carbohydrates include monosaccharides, disaccharides, oligosaccharides, complex polysaccharides or combinations thereof. Non-limiting examples of suitable types of monosaccharides used in a specific embodiment include trioses, tetrasaccharides, pentoses, hexoses, heptoses, octose and nonoses. The non-limiting example of the monosaccharide of suitable type used in the specific embodiment comprises glyceraldehyde, dihydroxyacetone, erythrose, threose, erythrulose, arabinose, lyxose, ribose, xylose, ribulose, xylulose, allose, altrose, galactose, glucose, gulose, idose, mannose, talose, fructose, psicose, sorbose, tagatose, mannoheptulose, pistachiotulose, octagose and sialic acid. The non-limiting example of the disaccharide of suitable type comprises sucrose, lactose and maltose. The non-limiting example of the oligosaccharide of suitable type comprises sucrose, maltotriose and maltodextrin. In other specific embodiments, carbohydrate is provided by corn syrup, beet sugar, sucrose, fruit juice or tea.

[0400] In other specific embodiments, the hydrating agent is a flavanol that provides cellular rehydration. Flavanols are a class of natural substances found in plants, typically containing a 2-phenylbenzopyrone backbone to which one or more chemical groups are attached. Non-limiting examples of flavanols suitable for use in the present application include catechin, epicatechin, epigallocatechin, epicatechin gallate, epicatechin 3-gallate, theaflavins, theaflavins 3-gallate, theaflavins 3'-gallate, theaflavins 3,3' gallate, thearubigin or a combination thereof. Several common sources of flavanols include tea plants, fruits, vegetables and flowers. In a preferred embodiment, the flavanols are extracted from green tea.

[0401] In some embodiments, to improve exercise endurance, the hydration agent is a glycerol solution. Ingestion of glycerol solution has been shown to have many physiological benefits, such as dilation of blood vessels, lowering heart rate, and lowering rectal temperature.

[0402] 2. Oral consumable product composition comprising SG composition

[0403] Another aspect of the present invention relates to an oral consumable composition containing the SG composition of the present application. In some embodiments, the composition comprises one or more SGs with a molecular weight greater than 965 Daltons. In some other embodiments, the one or more SGs with a molecular weight greater than 965 Daltons are selected from related SG#2, related SG#5, RU2, RT, RW, RW2, RW3, RU, SG-12, RH, RJ, RK, RK2, SG-Unk4, SG-Unk5, RD, RI, RL, RI3, SG-Unk6, RQ, RI2, RQ2, RQ3, RT1, related SG#4, RV2, RV, RY, RN, RM, 15α-OH RM, RO and RO2.

[0404] In one embodiment, the oral consumable composition comprises the SG composition of the present application, a sweetener composition containing the SG composition of the present application, or a flavoring agent containing the SG composition of the present application. The SG composition can be added to a consumable or a consumable matrix to produce a sweetened consumable or a flavored consumable.

[0405] The term "oral consumable composition" is used herein to refer to substances that come into contact with the mouth of humans or animals, including substances that are ingested into the mouth and then spit out, and substances that are drunk, eaten, swallowed or otherwise absorbed, which are safe for humans or animals when used in generally acceptable amounts.

[0406] Examples of oral consumable compositions include, but are not limited to, candies, condiments, chewing compositions, cereal compositions, baked goods, dairy products and sweetener compositions thereof, beverages and drinks, pharmaceutical compositions, smoked compositions, and oral hygiene compositions. The consumables may be sweet or non-sweet.

[0407] The oral consumable composition may optionally include the additives, sweeteners, functional ingredients, and combinations thereof described herein.Any of the additives, sweeteners, and other ingredients described above may be present in the oral consumable composition.

[0408] Consumer products using the SG composition of the present application are also suitable for processed agricultural products, livestock products or seafood; processed meat products such as sausages, etc.; packaged products, pickled products, pickled products cooked in soy sauce, delicacies, snacks; soups; snacks such as potato chips, biscuits, etc.; chopped fillers, leaves, stems, dry, homogenized leaves and animal foods.

[0409] A. Candy

[0410] In some embodiments, the oral consumable composition containing the SG composition of the present application is a candy. As referred to herein, "candy" can be a sweet, fruit, candy or the like. Candy usually has a basic composition component and a sweetener component. "Basic composition" refers to any composition that can be used as a food and provides a matrix for carrying a sweetener. The SG composition of the present application or a sweetener composition containing the same ingredients can be used as a sweetener component. Candy can be any food form that is generally considered to be rich in sugar or generally sweet.

[0411] According to a specific embodiment of the present application, candy can be a baked product such as cakes; desserts such as yogurt, jelly, drinking jelly, pudding, Bavarian cream, milk jelly, cake, chocolate cake, mousse, etc., sweet foods eaten during tea breaks or meals eaten afterwards; frozen foods; cold desserts, such as ice cream-like substances such as ice cream, ice milk, milk ice, etc. (foods in which sweeteners and various other raw materials are added to milk, and the mixture is stirred and frozen), and ice candies such as frozen fruit dew, dessert ice cream, etc. (foods in which various other types of raw materials are added to sugary liquids, and the mixture is stirred and frozen); general candies, such as baked candies or steamed candies such as baked biscuits, cookies, bread filled with jam, sesame crisp candies, Argentine sweets (alfajo r), etc.; rice cakes and snacks; tabletop products; general sucrose candies such as chewing gum (for example, the composition includes a substantially water-insoluble component, a chewable gum base, such as gum or its substitute, including jetulong, guttakay rubber or certain edible natural synthetic resins or waxes), hard candies, soft candies, mints, nougat, jelly, soft candies, milk candies, toffees, Swiss milk tablets, licorice candies, chocolates, gelatin candies, marshmallows, almonds, divine, marshmallows, etc.; seasonings include fruit sauces, chocolate sauces, etc.; edible gels; frostings include cream cheese, flour paste, whipped cream, etc.; jams include strawberry jam, jam, etc.; breads include sweet breads, etc. or other starch products, and combinations thereof.

[0412] The basic composition suitable for the embodiment of the present application may include flour, yeast, water, salt, butter, eggs, milk, milk powder, liquor, gelatin, nuts, chocolate, citric acid, tartaric acid, fumaric acid, natural flavors, artificial flavors, pigments, polyols, sorbitol, isomalt, maltitol, lactitol, malic acid, magnesium stearate, lecithin, hydrogenated glucose syrup, glycerol, natural or synthetic gum, starch, etc., and combinations thereof. These ingredients are generally considered to be safe (GRAS) and / or approved by the U.S. Food and Drug Administration (FDA). According to a specific embodiment of the present application, the content of the basic composition in candy is about 0.1wt% to about 99wt%.

[0413] The basic composition of candy can optionally include other artificial or natural sweeteners, block sweeteners, or its combination.Block sweeteners include heat and non-caloric compounds.The non-limiting example of block sweeteners includes sucrose, glucose, maltose, dextrin, dry invert sugar, fructose, high fructose corn syrup, fructose, galactose, corn syrup block, tagatose, polyols (such as: sorbitol, mannitol, xylitol, lactitol, erythritol, maltitol), hydrogenated starch hydrolyzate, isomalt, trehalose and their mixture.In general, the content range of block sweeteners in candy is very wide, specifically depends on the specific embodiment of candy and the sweetness needed.Those of ordinary skill in the art are easy to determine the suitable amount of block sweeteners.

[0414] In a specific embodiment, the candy comprises the SG composition of the present application or a sweetener composition containing the same ingredients and a basic composition. In general, the content range of the SG composition of the present application or a sweetener composition containing the same ingredients in the candy is very wide, depending on the specific embodiment of the candy and the desired sweetness.

[0415] B. Seasoning

[0416] In some embodiments, the consumables comprising the SG composition of the present application or the sweetener composition containing the composition are condiments. The condiments used in the present invention are compositions for enhancing or improving the flavor of food or beverages. Non-limiting examples of condiments include ketchup (catsup); mustard; barbecue sauce; butter; red pepper sauce; chutney; cocktail sauce; curry; dips; fish sauce; horseradish; hot pepper sauce; jelly, jam, sweet jam, or pickles; mayonnaise; peanut butter; seasonings; mayonnaise with ingredients; salad dressings (e.g., oil and vinegar, Caesar, French, ranch, blue cheese, Russian, Thousand Island, Italian and balsamic vinegar), salsa; pickles; soy sauce; steak sauce; syrup; seasoning sauce and Worcestershire sauce.

[0417] The seasoning base generally includes a mixture of different ingredients, non-limiting examples of which include vehicles (e.g., water and vinegar); flavoring agents or seasonings (e.g., salt, pepper, garlic, mustard, onion, chili, turmeric, and combinations thereof); fruits, vegetables, or products thereof (e.g., tomatoes or tomato products (sauce, puree), juice, peel juice, and combinations thereof); oils or oil emulsions, especially vegetable oils; thickeners (e.g., xanthan gum, edible starch, other hydrocolloids, and combinations thereof); and emulsifiers (e.g., egg yolk solids, protein, gum arabic, locust bean gum, guar gum, karaya gum, tragacanth gum, carrageenan, pectin, propylene glycol alginate, sodium carboxymethylcellulose, polysorbates, and combinations thereof). The formulation of the seasoning base and the method for its preparation are well known to those of ordinary skill in the art.

[0418] In general, condiments also include caloric sweeteners, such as sucrose, high fructose corn syrup, molasses, honey or brown sugar. In the exemplary embodiment of the condiments provided in the present application, the SG composition of the present application or a sweetener composition containing the composition is used to replace traditional caloric sweeteners. Therefore, it is desirable that the condiment composition includes the SG composition of the present application or a sweetener composition containing the composition and a condiment base.

[0419] The seasoning composition may optionally include other natural and / or synthetic high-potency sweeteners, block sweeteners, pH adjusters (such as lactic acid, citric acid, phosphoric acid, hydrochloric acid, acetic acid, and combinations thereof), fillers, functional aids (such as pharmaceutical agents, nutrients, or ingredients in food or plants), flavors, pigments, or combinations thereof.

[0420] C. Chewing Composition

[0421] In some embodiments, the consumer product comprising the steviol composition of the present application is a chewing composition. The term "chewing composition" includes chewing gum compositions, chewing tobacco, smokeless tobacco, snuff, chewing gum and other compositions that are chewed and spit out.

[0422] The chewing gum composition generally includes a water-soluble part and a water-insoluble chewing gum base. The water-soluble part usually includes the SG composition of the present application or a sweetener composition containing the composition, and part of the flavoring agent is consumed during chewing, while the insoluble gum base part is retained in the mouth. The insoluble gum base usually determines whether the gum is considered to be chewing gum, bubble gum or functional chewing gum.

[0423] Insoluble gum base, generally present in the chewing gum composition in an amount of about 15 wt % to about 35 wt %, generally includes a combination of elastomers, softeners (plasticizers), emulsifiers, resins and fillers. These ingredients are generally considered food grade, generally recognized as safe (GRA), and / or approved by the U.S. Food and Drug Administration (FDA).

[0424] Elastomer is the main component of gum base, providing elasticity and adhesion to gum, and may include one or more natural rubber (such as smoked latex, latex liquid, or guayule); natural gum (such as jelutong, perillo, lecha, balata, chocolate iron wire, tachya, rosindinha, chicle, and gutta-percha); or synthetic elastomer (such as butadiene-styrene copolymer, isobutylene-isoprene copolymer, polybutadiene, polyisobutylene, vinyl polymer elastomer). In a specific embodiment, the content of elastomer in the gum base is about 3wt% to about 50wt%.

[0425] Resin is used to change the hardness of gum base, and helps to soften the elastomer component of gum base. The non-limiting example of suitable resin includes rosin ester, terpene resin (for example, terpene resin obtained from α-pinene, β-pinene and / or D-limonene), polyvinyl acetate, ethylene polymer, ethylene glycol diacetate, vinyl acetate and vinyl laurate copolymer. The non-limiting example of rosin ester includes glycerol ester of partially hydrogenated rosin, glycerol ester of polymerized rosin, glycerol ester of part dimerized rosin, glycerol ester of rosin, pentaerythritol ester of partially hydrogenated rosin, methyl ester of rosin, or methyl ester of partially hydrogenated rosin. In a specific embodiment, the content of resin in gum base is about 5wt% to about 75wt%.

[0426] Softeners, also known as plasticizers, are used to change the ease of chewing and / or mouthfeel of the chewing gum composition. In general, softeners include oils, greases, waxes and emulsifiers. Non-limiting examples of oils and greases include tallow, hydrogenated tallow, hydrogenated or partially hydrogenated vegetable oils (such as soybean, rapeseed, cottonseed, sunflower seeds, palm, coconut, corn, safflower, or palm kernel oils), cocoa butter, glyceryl monostearate, triacetin, glyceryl rosin ester, lecithin, monoglyceride, diglyceride, acetylated triglyceride, monoglyceride and free fatty acids. Non-limiting examples of waxes include polypropylene / polyethylene / Fischer-Tropsch wax, paraffin, microcrystalline wax, natural wax (such as candlewood, beeswax and palm wax). Microcrystalline wax, especially those with very high crystallinity and high melting point, can also be used as excipients or structural modifiers. In a specific embodiment, the content of softener in gum base is about 0.5wt% to about 25wt%.

[0427] Emulsifiers are used to form a uniform dispersion of insoluble and soluble phases in the chewing gum composition and have plasticizing properties. Suitable emulsifiers include glyceryl monostearate (GMS), lecithin (phosphatidylcholine), polyglycerol polyricinoleate (PPGR), monoglycerides and diglycerides of fatty acids, glyceryl distearate, tracetin, acetylated monoglyceride, triacetin and magnesium stearate. In a specific embodiment, the content of the emulsifier in the gum base is about 2wt% to about 30wt%.

[0428] The chewing gum composition can also include adjuvants or fillers in the gum base or soluble portion of the chewing gum composition. Suitable adjuvants and fillers include lecithin, inulin, polydextrin, calcium carbonate, magnesium carbonate, magnesium silicate, ground limestone, aluminum hydroxide, aluminum silicate, talcum powder, clay, alumina, titanium dioxide and calcium phosphate. In a specific embodiment, lecithin can be used as an inert filler to reduce the viscosity of the chewing gum composition. In other specific embodiments, lactic acid copolymers, proteins (such as gluten and / or corn protein) and / or guar can be used to create more biodegradable glue. The content of adjuvants or fillers in the gum base is generally up to about 20wt%. Other optional ingredients include coloring agents, whitening agents, preservatives and flavoring agents.

[0429] In a specific embodiment of the chewing gum composition, the gum base comprises about 5 wt % to about 95 wt %, preferably about 15 wt % to about 50 wt %, more preferably about 20 wt % to about 30 wt % of the chewing gum composition.

[0430] The soluble portion of the chewing gum composition may optionally include other artificial or natural sweeteners, bulk sweeteners, softeners, emulsifiers, flavors, colorants, adjuvants, fillers, functional agents (such as pharmaceuticals or nutrients) or combinations thereof. Suitable examples of softeners and emulsifiers are described above.

[0431] Bulk sweeteners include caloric and non-caloric compounds. Non-limiting examples of bulk sweeteners include sucrose, dextrose, maltose, dextrin, dried invert sugar, fructose, high fructose corn syrup, levulose, galactose, corn syrup solids, tagatose, polyols (such as sorbitol, mannitol, xylitol, lactitol, erythritol and maltitol), hydrogenated starch hydrolysate, isomaltose, trehalose and mixtures thereof. In a specific embodiment, the content of bulk sweeteners in the chewing gum composition is about 1wt% to about 75wt%.

[0432] Flavoring agent can be used in the insoluble gum base or soluble part of chewing gum composition.This kind of flavoring agent can be natural or artificial flavoring agent.In a specific embodiment, flavoring agent comprises essential oil (such as oil derived from plant or fruit), peppermint oil, spearmint oil, other peppermint oil, clove oil, cinnamon oil, deer hoof grass, laurel, thyme, cedar leaf, nutmeg, red bell pepper, sage, cardamom and the oil of almond.In other specific embodiments, flavoring agent comprises plant extract or fruit essential oil (such as apple, banana, watermelon, pear, peach, grape, strawberry, raspberry, cherry, plum, pineapple, apricot and its mixture).Still in other specific embodiments, flavoring agent comprises citrus flavoring agent, such as extract, essence, or lemon oil, lime, citrus, grape, citron or kumquat.

[0433] In some embodiments, the chewing gum composition comprises the SG composition of the present application or a sweetener composition containing the composition and a gum base.

[0434] D. Cereal Composition

[0435] In some embodiments, the consumer product containing the steviol composition of the present application includes a cereal composition. Cereal compositions are usually eaten as staple foods or snacks. Non-limiting examples of cereal compositions for certain embodiments include ready-to-eat cereals and hot cereals. Ready-to-eat cereals refer to cereals that consumers can eat without further processing (i.e., cooking). Examples of ready-to-eat cereals include breakfast cereals and snack foods. Breakfast cereals are usually processed to produce flakes, flakes, fluffy or extruded shapes. Breakfast cereals are generally eaten cold, often mixed with milk and / or fruit. Snack foods include, for example, energy bars, rice cakes, oatmeal, and nutrition bars. Hot cereals are usually cooked before eating, usually in milk or water. Non-limiting examples of hot cereals include grits, porridge, corn porridge, rice and oats.

[0436] Cereal compositions generally include at least one cereal component. As used herein, the term "cereal component" refers to materials such as all or part of a cereal, a whole grain or part of a seed, and all or part of a grass. Non-limiting examples of cereal components used in some embodiments include maize, wheat, rice, barley, bran, bran endosperm, bulgur, soghum, chestnut, oat, rye, triticale, buckwheat, fonio, quinoa, beans, soybeans, amaranth, teff, spelt, and kaniwa.

[0437] In some embodiments, the cereal composition includes the SG composition of the present application or a sweetener composition containing the composition of the present application and at least one cereal ingredient. The SG composition of the present application or a sweetener composition containing the composition of the present application can be added to the cereal composition in various ways, for example, as a coating, a frosting, a glaze, or a matrix mixture (i.e., added as an ingredient to the cereal blend before preparing the final cereal product).

[0438] Therefore, in a specific embodiment, the SG composition of the present application or a sweetener composition containing the composition of the present application is added to the cereal composition as a base mixture. In one embodiment, the SG composition of the present application or a sweetener composition containing the composition of the present application is blended with hot cereals before cooking to provide a sweetened hot cereal product. In another embodiment, the SG composition of the present application or a sweetener composition containing the composition of the present application is blended with a cereal base before the cereal is extruded.

[0439] In other specific embodiments, the SG composition of the present application or the sweetener composition containing the composition of the present application is added to the cereal composition as a coating, for example, mixed with food-grade oil, and then the mixture is applied to the cereal food. In different embodiments, the SG composition of the present application or the sweetener composition containing the composition of the present application and the food-grade oil can be applied to the cereal food respectively, and the oil can be applied first, or the sweetener can be applied first. Non-limiting examples of food-grade oils for specific embodiments include vegetable oils such as corn oil, soybean oil, cottonseed oil, peanut oil, coconut oil, rapeseed oil, olive oil, sesame oil, palm oil, palm kernel oil, and mixtures thereof. In another embodiment, food-grade fat can be used to replace oil, but before applying fat to cereal food, the fat must be melted first.

[0440] In another embodiment, the SG composition of the present application or the sweetener composition containing the composition is added to the cereal composition as a syrup. Non-limiting examples of syrups suitable for specific embodiments include corn syrup, honey syrup and honey syrup solids, maple syrup and maple syrup solids, sucrose, isomaltose, polydextrose, polyols, hydrogenated starch hydrolysates, aqueous solutions thereof, and mixtures thereof. In another embodiment, the SG composition of the present application or the sweetener composition containing the composition is mixed with a syrup and a food-grade oil or fat to form a mixture, and then the mixture is applied to the cereal food as a syrup. In another embodiment, a gum system, for example, gum arabic, carboxymethyl cellulose, or algin, can be added to the syrup to provide structural support. In addition, the syrup may also include a colorant and may also include a flavoring agent.

[0441] In another embodiment, the SG composition of the present application or the sweetener composition containing the composition is added to the cereal composition as a frosting mixture. In one embodiment, the SG composition of the present application or the sweetener composition containing the composition is mixed with water and a frosting agent (frosting agent) and then applied to the cereal food. Non-limiting examples of frosting agents suitable for some embodiments include maltodextrin, sucrose, starch, polyols, and mixtures thereof. The frosting mixture may also include food grade oil, food grade fat, colorant, and / or flavoring agent.

[0442] Generally speaking, the amount of the SG composition of the present application or the sweetener composition containing the composition in the cereal composition varies widely depending on the particular type of the cereal composition and its desired sweetness. A person of ordinary skill in the art can easily determine the appropriate amount of sweetener to be added to the cereal composition.

[0443] E. Baked goods

[0444] In some embodiments, the consumer product comprising the steviol composition of the present application is a baked food. Baked food as described herein includes ready-to-eat foods and all prepared baked foods, flour and mixing materials that need to be prepared before use. Non-limiting examples of baked foods include cakes, crackers, cookies, brownies, muffins, rolls, bagels, donuts, strudels, desserts, croissants, soft cakes, bread, bakery products, and loaves.

[0445] According to the embodiments of the present application, preferred baked goods can be divided into three groups: bread-type dough (such as white bread, processed bread, soft fruit bread, hard bread rolls, bagels, pizza dough, and Mexican tortillas), sweet dough (such as jam bread, croissants, crackers, muffins, pie crusts, rolls and cookies) and batter (for example, cakes such as yeast dough, pounds, devil's food, cheesecake and layer cake, donuts or other yeast-raised cakes, brownies and muffins). Generally, the characteristics of dough are based on flour, while the characteristics of batter are more based on water.

[0446] According to a specific embodiment of the present application, the baked food comprises a mixture of sweetener, water and fat. According to many embodiments of the present application, the prepared baked food also comprises flour to prepare dough or batter. The term "dough" described here refers to a mixture of flour and other components that is hard enough to knead or roll eggs. The term "batter" described here comprises flour, liquid (such as milk or water) and other components, and is thin enough to pour or remove from a spoon. It is desirable that, according to a specific embodiment of the present application, the amount of flour in the baked food ranges from about 15 to about 60%, more desirably about 23 to about 48%, by dry weight.

[0447] The type of flour is selected based on the target product. Generally, the flour comprises edible non-toxic flour used in baked goods. According to a specific embodiment, the flour can be bleached baking flour, general purpose flour or unbleached flour. In other specific embodiments, flour treated in other ways can also be used. For example, in a specific embodiment, flour can be enriched with vitamins, minerals or proteins. Non-limiting examples of suitable flour used in the specific embodiments of the present application include wheat, cornmeal, whole grains, part whole grains (wheat, bran and oatmeal), and combinations thereof. In a specific embodiment, starch or starch-containing materials can also be used as flour. Generally, conventional food starch comes from potatoes, corn, wheat, barley, oats, cassava, bamboo and sago. Modified starch and pregelatinized starch can also be used in the specific embodiments of the present application.

[0448] The type of fat or oil used in the specific embodiment of the present application comprises any edible fat suitable for baking, oil or its combination. The non-limiting examples of the fat used in the specific embodiment of the present application include vegetable oil, animal tallow, lard, marine oil and its composition. According to the specific embodiment, the fat can be fractionated, partially hydrogenated and / or strengthened. In other specific embodiments, the ideal fat comprises reduced, low-calorie, or non-digestible fat, fat substitute or synthetic fat. Still in the specific embodiment, shortening, fat and a mixture of high melting point and low melting point fat can also be used. In a specific embodiment, shortening is only required to come from triglycerides of plant sources (such as cottonseed oil, soybean oil, peanut oil, linseed oil, sesame oil, palm oil, palm kernel oil, rapeseed oil, safflower oil, coconut oil, corn oil, sunflower seed oil and its mixture). Synthetic or natural triglycerides of fatty acids with chain lengths of 8 to 24 carbon atoms can also be used in specific embodiments. Desirably, according to particular embodiments of the present application, the amount of fat in the baked good ranges from about 2 to about 35%, more desirably from about 3 to about 29%, by weight on a dry basis.

[0449] According to a specific embodiment of the present application, the baked food may also include enough water to provide the desired consistency so that the baked food can be properly shaped, machined and cut before or after cooking. The total moisture content of the baked food includes any water directly added to the baked food and the water present in each additional component (e.g., free, the moisture content is generally about 12 to about 14 wt%). Desirably, according to a specific embodiment of the present application, the amount of water present in the baked food reaches about 25 wt% of the baked food.

[0450] According to the specific embodiment of the present application, baked food can also include many other conventional components, such as leavening agent, flavoring agent, pigment, milk, milk byproduct, egg, egg byproduct, cocoa powder, vanilla or other flavoring agent, and inclusions such as nuts, raisins, cherries, apples, apricots, peaches, other fruits, citrus peels, preservatives, coconut, flavored potato chips such as chocolate potato chips, butterscotch potato chips and caramel potato chips and combinations thereof. In a specific embodiment, the baked food can also include emulsifiers, such as lecithin and monoglyceride.

[0451] According to a specific embodiment of the present application, the leavening agent can include a chemical leavening agent or a yeast leavening agent. The non-limiting examples of chemical leavening agents suitable for use in the present application specific embodiment include baking soda (such as sodium, potassium or aluminum bicarbonate), leavening acid (such as sodium aluminum phosphate, monocalcium phosphate or dicalcium phosphate) and combinations thereof.

[0452] According to another specific embodiment of the present application, cocoa powder may contain natural or "Dutched" chocolate, which comes from a substantial portion of fat or cocoa butter that has been squeezed or removed by solvent extraction, pressing or other means. In a specific embodiment, there is additional fat in cocoa butter, so it is necessary to reduce the amount of fat in baked goods containing chocolate. In a specific embodiment, it is necessary to add a large amount of chocolate compared to cocoa powder in order to provide an equal amount of flavor and coloring.

[0453] In general, baked goods also include caloric sweeteners, such as sucrose, high fructose corn syrup, erythritol, molasses, honey or brown sugar. In the exemplary embodiments of baked goods provided herein, caloric sweeteners are replaced with part or all of the SG composition of the present application or the sweetener composition comprising the composition. Therefore, in one embodiment, the baked goods include SG composition or the sweetener composition containing the composition combined with fat, water and optional flour. In a specific embodiment, the baked goods arbitrarily include other natural and / or synthetic high-efficiency sweeteners and / or bulking sweeteners.

[0454] F. Dairy products

[0455] In some embodiments, the consumer product comprising the steviol composition of the present application is a dairy product. Dairy products and methods for preparing suitable dairy products using the SG composition of the present application are well known to those skilled in the art. The dairy products described here include raw milk or foods produced from raw milk. Non-limiting examples of dairy products suitable for use in the embodiments of the present application include raw milk, cream, sour cream, fresh cream, buttermilk, fermented buttermilk, milk powder, condensed milk, evaporated milk, butter, cheese, skim lactic acid cheese, cream cheese, yogurt, ice cream, soft cream ice cream, frozen yogurt, Italian ice cream, Starbucks coffee, yogurt, fermented milk (filmjolk), kajmak, kephir, viili, kumiss, airag, ice milk, casein, ayran, lassi, khoa or a combination thereof.

[0456] Milk is the fluid secreted by the mammary glands of female mammals for the nutrition of their children. The female ability to produce milk is one of the defining characteristics of mammals and the primary source of nutrition for newborns before they can digest more diverse foods. In a specific embodiment, the dairy product is derived from raw milk of cows, goats, sheep, horses, donkeys, camels, buffalo, oxen, reindeer, elk, or humans.

[0457] In a specific embodiment, the processing of dairy products derived from raw milk generally includes the steps of pasteurization, creaming, and homogenization. Although raw milk can be consumed without being pasteurized, it is usually pasteurized to destroy harmful microorganisms such as bacteria, viruses, protozoa, molds, and yeasts. Pasteurization generally involves heating the milk to a high temperature for a short period of time to substantially reduce the number of microorganisms, thereby reducing the risk of disease.

[0458] Creaming is traditionally followed by the pasteurization step and involves separating the milk into a high fat cream layer and a low fat cream layer. The milk will separate into the milk and cream layers after standing for 12 to 24 hours. The cream rises to the top of the milk layer and can be extracted and used as a separate dairy product. Alternatively, a centrifuge can be used to separate the cream from the milk. The remaining milk is classified according to the fat content of the milk, non-limiting examples of which include whole, 2%, 1%, and skim milk.

[0459] After removing the desired fat content from the milk by creaming, the milk is often homogenized. Homogenization prevents cream from separating from the milk, and generally involves pumping the milk through a narrow tube at high pressure to break up the fat globules in the milk. Heat sterilization, creaming, and homogenization of milk are common, but not required, to produce a consumer dairy product. Therefore, suitable dairy products for use in embodiments of the present invention may be free of processing steps, may undergo a single processing step, or a combination of processing steps described herein. Suitable dairy products for use in embodiments of the present invention may also undergo processing steps in addition to (or in addition to) the processing steps described herein.

[0460] Specific embodiments of the present invention include dairy products prepared from cow's milk by additional processing steps. As described above, cream can be extracted from the top of the milk, or separated from the milk using a mechanical centrifuge. In a specific embodiment, the dairy product includes sour cream, a fat-rich dairy product obtained by fermenting cream using bacterial culture. During fermentation, the bacteria produce lactic acid, which acidifies and thickens the cream. In another specific embodiment, the dairy product includes vegetable cream, a high-fat cream slightly acidified with bacterial culture in a similar manner to acidified cream. Vegetable cream is generally not as thick or sour as sour cream. In still another specific embodiment, the dairy product includes fermented buttermilk. Fermented buttermilk is obtained by adding bacteria to cow's milk. The resulting fermentation (wherein the bacterial culture converts lactose into lactic acid) produces the lactic acid taste of fermented butter. Although it is produced in a different way, fermented buttermilk is generally similar to traditional buttermilk, which is a by-product of cheese production.

[0461] According to other specific embodiments of the present invention, the dairy product includes milk powder, condensed milk, evaporated milk, or a combination thereof. Milk powder, condensed milk, and evaporated milk are generally produced by removing water from cow's milk. In a particular example, the dairy product includes milk powder containing dry cow's milk solids with a low water content. In a specific embodiment, the dairy product includes milk powder. The milk powder includes dry cow's milk solids with a low water content. In another specific embodiment, the dairy product includes condensed milk, which generally includes cow's milk with reduced water content and added sweeteners, producing a thick and sweet product with a long shelf life. Still in a specific embodiment, the dairy product includes evaporated milk. Evaporated milk generally includes fresh homogenized cow's milk, which has removed 60% of the water, which has been condensed with additives such as vitamins and stabilizers, improved nutritional value, packaged, and finally sterilized. According to another specific embodiment of the present invention, the dairy product includes dry creamer and the SG composition of the present application or a sweetener composition comprising the composition.

[0462] In another embodiment, the dairy products provided herein include butter. Butter is generally prepared by churning fresh or fermented cream or milk. Butter generally includes cheese fat containing droplets containing mostly water and milk protein. The churning process damages the membrane surrounding the particles of cheese fat, allowing the cream to bind and separate from the rest of the cream. In still another embodiment, the dairy product includes buttermilk, which is the sour liquid left after cheese is produced from whole milk by the churning process.

[0463] In another specific embodiment, the dairy product includes cheese, a solid food produced by coagulating milk using a combination of rennet or a rennet substitute and acidification. Rennet (a natural complex of enzymes produced in the stomach of mammals to digest milk) is used in the preparation of cheese to coagulate milk so that the milk is divided into a solid called curd and a liquid called whey. Generally speaking, rennet comes from the stomach of young ruminants (such as calves); however, alternatively, the source of rennet includes some plants, microbial organisms, and generally modified bacteria, fungi, or yeasts. In addition, milk can be coagulated by adding acid such as citric acid. Generally speaking, a combination of rennet and / or acidification is used to coagulate milk. After the milk is divided into curd and whey, some cheeses are prepared by simply draining the liquid, salting, and packaging the curd. However, for most cheeses, more processing is required. Many different methods can be used to prepare hundreds of available cheeses. Processing methods include heating cheese, cutting it into small pieces to discharge liquid, salting, stretching, piling up, cleaning, molding, aging, and ripening. Some cheeses such as blue cheese are introduced with extra bacteria or mold before or during aging to give the final product flavor and fragrance. Cottage cheese is a cheese curd product with medium flavor, which is discharged with liquid but not compressed, so some whey is retained. Usually the curd is cleaned to remove acidity. Cream cheese is a soft, medium taste, white cheese with high fat content, which is produced by adding cream to cow's milk and coagulating to form abundant curd afterwards. Alternatively, cream cheese can be prepared from skim milk by adding cream to curd. It should be understood that, as used in the text, all solid foods produced by coagulating cow's milk are included.

[0464] In another specific embodiment, the dairy product includes yogurt. Yogurt is generally produced by bacterial fermentation of cow's milk. Lactose fermentation produces lactic acid, which acts on the protein in cow's milk to produce yogurt, which is like a gel structure and has a sour taste. In a specific embodiment, yogurt can be sweetened and flavored with a sweetener. The non-limiting examples of flavoring agents include, but are not limited to, fruits (such as peaches, strawberries, bananas), vanilla extract, and chocolate. The yogurt used in the text also includes various yogurts with different concentrations and viscosities, such as yogurt (dahi), curd (dadih) or dadiah, concentrated yogurt (labneh) or labaneh, bulgarian, kefir (kefir) and matsoni. In another specific embodiment, the dairy product includes a beverage with yogurt as a matrix, also known as drinkable yogurt or yogurt smoothie (yogurtsmoothie). In a specific embodiment, a beverage with yogurt as a matrix may include a sweetener, a flavoring agent, other ingredients, or a combination thereof.

[0465] Other dairy products besides the dairy products described herein can be used in the specific embodiments of the present invention. Such dairy products are well known to those skilled in the art, and non-limiting examples thereof include yogurt, milk and juice, coffee, tea, kefir, kefir, curdled milk, kumis, cheese, milk ice, casein, ayran, lassi, and ricotta cheese.

[0466] According to a specific embodiment of the present invention, the dairy composition may also include other additives. Non-limiting examples of suitable additives include sweeteners and flavoring agents such as chocolate, strawberry, and banana. The specific embodiments of the dairy composition provided herein may also include additional nutritional supplements such as vitamins (e.g., vitamin D) and minerals (e.g., calcium) to improve the nutritional composition of cow's milk.

[0467] In a specific embodiment, the dairy composition comprises the SG composition of the present application and a sweetener composition comprising the composition combined with a dairy product.

[0468] G. Sweetener Composition

[0469] In some embodiments, the consumer product comprising the steviol composition of the present application is a sweetener composition. In some embodiments, the tabletop sweetener composition may further include at least one filler, additive, anti-caking agent, functional ingredient or a combination thereof.

[0470] Suitable "fillers" include, but are not limited to, maltodextrin (10DE, 18DE, or 5DE), corn syrup solids (20 or 36DE), sucrose, fructose, glucose, invert sugar, sorbitol, xylose, ribulose, mannose, xylitol, mannitol, galactitol, erythritol, maltitol, lactitol, isomalt, maltose, sugar, lactose, inulin, glycerol, propylene glycol, polyols, polydextrose, oligofructose, cellulose and cellulose derivatives, and mixtures thereof. In addition, according to other embodiments of the present application, granulated sugar (sucrose) or other caloric sweeteners such as crystalline fructose, other carbohydrates or sugar alcohols can provide good content uniformity without significantly increasing calories, so they can be used as fillers.

[0471] The phrases "anti-caking agent" and "flow agent" are used herein to refer to any composition that contributes to content uniformity and uniform solubility. In some embodiments, non-limiting examples of anti-caking agents include creams of tartar, calcium silicate, silicon dioxide, microcrystalline cellulose (Avicel, FMC BioPolymer, Philadelphia, Pennsylvania) and tricalcium phosphate. In one embodiment, the anti-caking agent is present in the tabletop sweetener composition in an amount of about 0.001 wt % to about 3 wt %.

[0472] The tabletop sweetener composition can be packaged in any form known in the art. Non-limiting forms include, but are not limited to, powder, granules, tablets, sachets, balls, cubes, solids and liquids.

[0473] In one embodiment, the tabletop sweetener composition is a single serving (portion control) package including a dry mix. The dry mix preparation may generally include a powder or granules. Although the tabletop sweetener composition may be a package of any size, the enumerated non-limiting example of a traditional portion control tabletop sweetener package is approximately 2.5 inches * 1.5 inches, which can hold about 1 gram of a sweetener composition whose sweetness is equivalent to 2 teaspoons of granulated sugar (about 8 grams). The amount of the composition of the present application or the sweetener composition containing the composition of the present application in a dry mix tabletop sweetener preparation may vary. In some embodiments, the content of the composition of the present application in a dry mix tabletop sweetener preparation may be about 1% (w / w) to about 10% (w / w).

[0474] Embodiments of solid tabletop sweeteners include cubes and flakes. The size of a non-limiting example of a conventional cube is comparable to a cube of standard granulated sugar, being approximately 2.2×2.2×2.2 cubic centimeters and weighing approximately 8 grams. In one embodiment, the solid tabletop sweetener is made in the form of tablets or any other form known to the skilled artisan.

[0475] Tabletop sweetener compositions can also be shown as liquid forms, wherein the compositions of the present application or the sweetener compositions containing the compositions are combined with liquid carriers. Non-limiting examples of carriers suitable for liquid tabletop sweeteners include water, polyols, glyceryl or citric acid groups dissolved in water and mixtures thereof. In order to obtain the desired sweetness profile, the sweetness suitable for the tabletop sweetener compositions of any form described in the present application or known in the art can be changed. For example, the sweetness of the tabletop sweetener compositions can be compared with the sweetness of standard sugar. In another embodiment, the sweetness of the tabletop sweetener compositions can be up to 100 times the sweetness of standard sugar. In another embodiment, the sweetness of the tabletop sweetener compositions can be up to 90 times, 80 times, 70 times, 60 times, 50 times, 40 times, 30 times, 20 times, 10 times, 9 times, 8 times, 7 times, 6 times, 5 times, 4 times, 3 times, 2 times the sweetness of standard sugar.

[0476] H. Beverages and drinks

[0477] In some embodiments, the beverage or drink comprises the SG composition of the present application or a sweetener composition containing the composition. The beverage may be sweetened or unsweetened. The SG composition of the present application or a sweetener composition containing the composition may be added to a beverage to sweeten the beverage or to increase its original sweetness or flavor profile.

[0478] "Drink" as used herein is a beverage, beverage concentrate, beverage syrup or powdered beverage that can be drunk at any time. Suitable beverages that can be drunk at any time include carbonated beverages and non-carbonated beverages. Carbonated beverages include but are not limited to frozen carbonated beverages, fortified sparkling beverages, cola, fruit-flavored beverages (such as lemon lime, orange, grape, strawberry and pineapple), ginger ale, soft drinks and root beer. Non-carbonated beverages include but are not limited to fruit juices, fruit-flavored fruit juices, fruit drinks, nectar drinks, vegetable juices, vegetable sauces, sports drinks, energy drinks, fortified water drinks, vitamin-enhanced water drinks (for example, water with natural or synthetic flavoring agents), coconut water, tea-type beverages (such as black tea, green tea, black tea, oolong tea), coffee, cocoa drinks, beverages containing milk ingredients (such as milk drinks, coffee containing milk ingredients, milk coffee, milk tea, fruit milk drinks), and beverages containing cereal extracts and smoothies.

[0479] Beverage concentrates and beverage syrups are made from an initial liquid base (e.g., water) and the desired beverage ingredients. Full-strength beverages are then prepared by adding more water. Powdered beverages are made by dry-mixing all the beverage ingredients without a liquid base. Full-strength beverages are then prepared by adding the full volume of water.

[0480] The beverage includes a matrix, i.e., a basic component, in which the components including the composition of the present application are dissolved. In one embodiment, the beverage includes water of beverage quality as a matrix, for example: deionized water, distilled water, reverse osmosis water, carbon-treated water, purified water, desalted water and combinations thereof can be used. Other suitable matrices include, but are not limited to, phosphoric acid, phosphate buffer, citric acid, citrate buffer and carbon-treated water.

[0481] In some embodiments, the beverage includes the SG composition of the present application. In some embodiments, the drink includes the sweetener composition of the present application.

[0482] The following concentrations of beverages can be provided using the composition of the present application or the sweetener composition of the present application.

[0483] In some embodiments, the total concentration of SG in the beverage is from about 50 ppm to about 900 ppm, for example: from about 50 ppm to about 600 ppm, from about 50 ppm to about 500 ppm, from about 50 ppm to about 400 ppm, from about 50 ppm to about 300 ppm, from about 50 ppm to about 200 ppm, from about 100 ppm to about 600 ppm, from about 100 ppm to about 500 ppm, from about 100 ppm to about 400 ppm, from about 100 ppm to about 300 ppm, from about 100 ppm to about 200 ppm, from about 200 ppm to about 600 ppm, from about 200 ppm to about 500 ppm, from about 200 ppm to about 400 ppm, from about 200 ppm to about 300 ppm, from about 300 ppm to about 600 ppm, from about 300 ppm to about 500 ppm, from about 300 ppm to about 400 ppm, from about 400 ppm to about 600 ppm, from about 400 ppm to about 500 ppm, from about 500 ppm to about 600 ppm.

[0484] I. Pharmaceutical Compositions

[0485] The term "pharmaceutical composition" includes solid, liquid and gaseous, ingestible materials having medicinal value, such as cough syrups, cough drops, medicinal sprays, vitamins, and chewable tablets.

[0486] J. Oral Hygiene Compositions

[0487] The term "oral hygiene composition" includes mouthwashes, mouth rinses, toothpastes, tooth polishes, tooth abrasives, mouth sprays, and mouth fresheners.

[0488] K. Smoking Composition

[0489] The term "smoking composition" includes cigarettes, pipes and cigars in this application, and all forms of tobacco, such as chopped fillers, leaves, stems, stems, cured homogenized leaves, reconstituted binders, tobacco dust in the form of flakes, particles or other forms, fine powder or other sources for reconstructing. "Smoking composition" also includes tobacco substitutes made with non-tobacco treatment, such as representative tobacco substitutes described in U.S. Patents 3529602, 3703177 and 4079742, which are incorporated herein by reference.

[0490] 3. Production method of SG composition

[0491] In another aspect, the present application relates to a method for producing the SG composition of the present application.

[0492] In some embodiments, the starting material for the production process of the SG composition is selected from a material comprising SG in pure form, an extract from the leaves of the Stevia plant, an intermediate or a liquid preparation.

[0493] In some embodiments, a method for preparing a treated SG composition having improved solubility in aqueous solution compared to untreated SG comprises the steps of: (1) mixing SG or a SG mixture with water, (2) heating the mixture while stirring until the mixture is completely dissolved to obtain a clear solution, (3) further stirring the solution at elevated temperature, (4) cooling to ambient temperature, and (5) subjecting the solution to spray drying. In step (2), the mixture may be heated to 30-200° C., preferably 40-120° C., more preferably 50-90° C., and most preferably 60-70° C. In an alternative method of the present invention, step (5) may be replaced by crystallization of SG or a SG composition.

[0494] In other embodiments, methods of preparing treated SG compositions having increased solubility in aqueous solutions compared to untreated SG include the step of removing or reducing non-SG off-flavor compounds.

[0495] The spray-dried compositions described herein can be prepared as a mixture first and then spray-dried, or prepared as separate components that are spray-dried and then combined. It should also be understood that when there are two or more components in the mixture, the amount of the components can vary between 1 wt / wt and 99 wt / wt of the components, and a total of 100% wt / wt is obtained.

[0496] The SG(s) or SG composition can be dissolved in a water / alcohol solution. The alcohol can be methanol, ethanol, propanol, isopropanol, n-butanol, isobutanol, sec-butanol, tert-butanol, n-pentanol, isopentanol, neopentyl alcohol, or a combination thereof.

[0497] The hydroalcoholic solution can be less than 60 vol% alcohol, less than 50 vol% alcohol, less than 40 vol% alcohol, less than 30 vol% alcohol, less than 20 vol% alcohol, less than 10 vol% alcohol, less than 5 vol% alcohol, less than 2 vol% alcohol, or less than 1 vol% alcohol.

[0498] In some embodiments, the SG composition of the present application is prepared by mixing the various components together. The various components of the SG composition can be commercially available or can be prepared by methods known to those of ordinary skill in the art, and combined (such as precipitation / coprecipitation, mixing, blending, grinding, mortar and pestle, microemulsion, solvothermal method, sonochemical method, etc.) or processed as defined in the present invention.

[0499] In some embodiments, a mixture of rebaudioside A and B is dissolved in an aqueous solution at elevated temperature and then cooled to room temperature.

[0500] In other embodiments, the mixture of rebaudioside A and D is dissolved in an aqueous solution at elevated temperature and then cooled to room temperature.

[0501] Still in some embodiments, the mixture of rebaudioside A, B and D is dissolved in an aqueous solution at elevated temperature and then cooled to room temperature.

[0502] Still in some embodiments, a mixture of rebaudioside A, B and D is dissolved in an aqueous solution at elevated temperature and then cooled to room temperature. The solution is then spray dried to provide a highly soluble stevia-based sweetener, such as a spray-dried SG composition. In some embodiments, the process for drying the solution employs spray drying the solution.

[0503] Taste-changing moieties, such as galactosides, can be added to the SG compositions of the present application to change the perceived sweetness of the SG compositions. For example, β-1,4-galactosyltransferase is used to replace β-1,4-galactosyl groups on the SG compositions in reactions well known in the art.

[0504] The SG composition of the present invention (in a purified state after spray drying) is generally a fine powder with a particle size ranging from about 1 to 100 microns. Fine powders are difficult to handle and difficult to mix with consumer product compositions (such as tea leaves, tobacco products, herb leaves, coffee and oral consumer product compositions). Moreover, generally, when the SG composition is used as a flavor modifier or enhancer, sweetener or co-sweetener, only a relatively small amount of the SG composition is used with the consumer product composition.

[0505] 4. How to use SG composition

[0506] In another aspect, the present invention relates to a method for using the SG composition of the present application.

[0507] According to another embodiment, a method of adding a product to an oral consumable product composition comprises mixing an SG composition with a carrier to form an SG composition-carrier mixture. Preferred carriers include water, ethanol, other alkyl alcohols used in food processing, or mixtures thereof. The resulting SG composition solution is contacted with the oral consumable product composition, and then the carrier is removed from the oral consumable product composition by evaporation or other means, and the SG composition residue is deposited in the oral consumable product composition. This method is particularly useful for adding the SG composition to tea leaves, herbal leaves, and other sweeteners, particularly granulated sucrose.

[0508] In some embodiments, the SG compositions of the present application are used as sweeteners in effective amounts with improved solubility and / or sensory profiles.

[0509] In some embodiments, the compositions of the present application are used as co-sweeteners in effective amounts with improved solubility and / or sensory profile.

[0510] In other embodiments, the compositions of the present application are used in effective amounts as flavoring agents.

[0511] The term "equisweet" is used herein to indicate that the sweetness of the composition is comparable to the sweetness of sugar.

[0512] For use as a co-sweetener, the present composition (e.g., vapor deposition of steam, ethanol, or alkanol atomized product on a co-sweetener) can be applied or infiltrated with other solid sweeteners such as granular or powdered sugar and synthetic sweeteners in a manner known in the sweetener field; mixed with solid sweeteners as a separate powder; co-crystallized with other solid sweeteners; or suspended or dissolved in liquid sweeteners such as corn syrup and honey. Commercial spray dryers can generally be used to generate product particle sizes suitable for the intended use in the ethanol purge and drying stages of industrial embodiments.

[0513] In some embodiments, the SG composition of the present application is used as a sweetener or flavoring agent in an orally consumable composition.

[0514] In some embodiments, the SG composition of the present application is used as a flavoring agent for improving or modifying consumer products. In some embodiments, the SG composition of the present invention, when used in an effective amount, improves or enhances the flavor characteristics of sweet, fruity, floral, herbal, spicy, aromatic, stimulating, "nut-like" (e.g., almonds, walnuts), "spicy" (such as cinnamon, cloves, nutmeg, anise and wintergreen), "non-citrus fruit flavor" (such as strawberry, cherry, apple, grape, raisin, tomato, gooseberry and blackberry), "citrus flavor" (such as orange, lemon, lime and grapefruit), and other useful flavors, including coffee, cocoa, mint, spearmint, vanilla and maple.

[0515] In some embodiments, the compositions of the present application are in an effective amount to sweeten, improve or enhance the taste, smell and / or texture of an orally consumable composition.

[0516] The term "effective amount" refers to an amount that produces a sensory perception. The use of an excessive amount of the SG composition may produce an undesirable flavor change or enhancement, just as too much sugar cannot be added to food or beverages. The amount of the SG composition can vary within a wide range, depending on the desired sensory effect to achieve the desired effect of the oral consumable composition and the properties of the initial composition.

[0517] The SG composition can be added to the oral consumable product composition by mixing the SG composition with the oral consumable product composition or by mixing the SG composition with ingredients of the oral consumable product composition.

[0518] SG composition can be used in tobacco and tobacco-related products, which are selected from cigarettes, cigars, snuff, chewing tobacco, other tobacco products, filters, cigarette papers and other smoking compositions. The smoking composition with sweetening, enhancing or changing flavor comprises a cigarette filler, which is selected from tobacco, reconstituted tobacco, non-tobacco substitutes and mixtures thereof, and an effective amount of SG composition. "Contain" refers to being included as a raw material and adsorbed on the material. In a variation of this specific embodiment, the smoking composition includes a filter containing the SG composition. The term "filter" described herein includes a smoking device such as a mouthpiece with a filter or flavor module in a combined cigar or cigarette, and includes acetate, cotton, charcoal and other fibers, flaky or granular filters. In another variation of this specific embodiment, the smoking composition includes a packaging device containing the SG composition, and in a variation of this embodiment, 0.003 to 0.30 parts by weight of the SG composition is added to 100 parts by weight of the smoking filler material. In a preferred variation of this embodiment, 0.015 to 0.30 parts by weight of the SG composition is added to 100 parts by weight of the smokable filler material.

[0519] The technical staff of flavor tobacco field understands that the effective amount of the described product that is added to the smoking composition can depend on the method that the described product is added to the smoking composition and the product is added to which part of the smoking composition. The product can be directly added to the smoking filling material of the smoking composition, the packaging device of the filter or the smoking composition. The product can be added to the filter by any means known to the technical staff of the filter field of flavor, including but not limited to the product being included in the fiber of the filter, in the sheet or the particle, the product is contained between two or more layers of the fiber of the fiber filter to form a triple filter, or the product is embedded in the smoking device, such as a cigarette holder.

[0520] It is obvious to those skilled in the art that only a portion of smoking filling material or filter needs to be processed with the SG composition, so mixing or other operations can be used to adjust the final or last smoke-generating agent within the effective or desired concentration range of the SG composition. In addition to the SG composition, other flavoring agents or aromatic additives known in the smoke-generating agent flavoring field can be used together with the SG composition and added to the smoke-generating agent together with the product. The representative flavoring agent used in the smoke-generating agent flavoring field comprises ethyl acetate, isoamyl acetate, propyl isobutyrate, isobutyl butyrate, ethyl butyrate, ethyl valerate, benzyl formate, menthol, limonene, thyme, pine terpenes, linalool, geraniol, citronellol, citral, peppermint oil, orange oil, coriander oil, lemon oil, borneol, cocoa powder extract, tobacco extract, licorice extract and fruit extract. Specific implementation plan

[0521] The following items numbered consecutively from 1 to 192 provide various aspects of the present application. In one embodiment of item 1, the present application provides:

[0522] 1. A composition comprising one or more SG of Table A.

[0523] 2. The composition described in item 1, comprising RA accounting for 15-35 wt% of the total SG in the composition and one or more SGs having a molecular weight greater than 965 Daltons and accounting for more than 1 wt% of the total SG in the composition.

[0524] 3. The composition described in item 2, wherein RA accounts for 20-30 wt% of the total SG in the composition.

[0525] 4. The composition according to any one of items 1 to 3, further comprising ST.

[0526] 5. The composition described in item 4, wherein ST accounts for 14-40 wt% of the total SG in the composition.

[0527] 6. The composition described in item 4, wherein ST accounts for 15-30 wt% of the total SG in the composition.

[0528] 7. The composition described in item 4, wherein ST accounts for 20-35 wt% of the total SG in the composition.

[0529] 8. The composition of any one of items 2-7, wherein the one or more SGs having a molecular weight equal to or greater than 965 Daltons are selected from related SG#2, related SG#5, RU2, RT, RW, RW2, RW3, RU, SG-12, RH, RJ, RK, RK2, SG-Unk4, SG-Unk5, RD, RI, RL, RI3, SG-Unk6, RQ, RI2, RQ2, RQ3, RT1, related SG#4, RV2, RV, RY, RN, RM, 15α-OH RM, RO and RO2.

[0530] 9. The composition of any one of items 2-8, wherein the one or more SGs having a molecular weight greater than 965 Daltons comprise RMs.

[0531] 10. The composition of item 9, wherein RM accounts for 0-0.4 wt% of the total SG of the composition.

[0532] 11. The composition of any one of items 1-10, wherein the one or more SGs having a molecular weight greater than 965 Daltons comprise RN.

[0533] 12. The composition according to item 11, wherein RN accounts for 0-2 wt% of the total SG of the composition.

[0534] 13. The composition of any one of items 1-12, wherein the one or more SGs having a molecular weight greater than 965 Daltons comprises RO.

[0535] 14. The composition of item 13, wherein RO accounts for 0.2-1.5 wt% of the total SG in the composition.

[0536] 15. The composition of any one of items 1-14, wherein the one or more SGs having a molecular weight greater than 965 Daltons comprises RH.

[0537] 16. The composition of item 15, wherein RH accounts for 0-0.3 wt% of the total SG of the composition.

[0538] 17. The composition of any one of items 1-16, wherein the one or more SGs having a molecular weight greater than 965 Daltons comprise RI.

[0539] 18. The composition of item 17, wherein RI accounts for 0-0.6 wt% of the total SG of the composition.

[0540] 19. The composition of any one of items 1-18, wherein the one or more SGs having a molecular weight greater than 965 Daltons comprises RI3.

[0541] 20. The composition of item 19, wherein RI3 accounts for 0.4-1 wt% of the total SG of the composition.

[0542] 21. The composition of any one of items 1-20, wherein the one or more SGs having a molecular weight greater than 965 Daltons comprises RJ.

[0543] 22. The composition of item 21, wherein RJ accounts for 0-0.7 wt% of the total SG of the composition.

[0544] 23. The composition of any one of items 1-22, wherein the one or more SGs having a molecular weight greater than 965 Daltons comprises RK.

[0545] 24. The composition of item 23, wherein RK accounts for 0-0.5 wt% of the total SG in the composition.

[0546] 25. The composition of any one of items 1-24, wherein the one or more SGs having a molecular weight greater than 965 Daltons comprises RL.

[0547] 26. The composition of item 25, wherein RL accounts for 0-0.4 wt% of the total SG of the composition.

[0548] 27. The composition of any one of items 1-26, wherein the one or more SGs having a molecular weight greater than 965 Daltons comprises RU.

[0549] 28. The composition of item 27, wherein RU accounts for 0.1-0.5 wt% of the total SG of the composition.

[0550] 29. The composition of any one of items 1-28, wherein the one or more SGs having a molecular weight greater than 965 Daltons comprise RV.

[0551] 30. The composition of item 29, wherein RV accounts for 0-0.6 wt% of the total SG of the composition.

[0552] 31. The composition of any one of items 1-30, wherein the one or more SGs having a molecular weight greater than 965 Daltons comprises RV2.

[0553] 32. The composition of item 31, wherein RV2 accounts for 0-0.6 wt% of the total SG of the composition.

[0554] 33. The composition of any one of items 1-32, wherein the one or more SGs having a molecular weight greater than 965 Daltons comprises RY.

[0555] 34. The composition of item 33, wherein RY accounts for 0-0.4 wt% of the total SG of the composition.

[0556] 35. The composition of item 1, comprising one or more SGs having a molecular weight equal to or greater than 966 Daltons.

[0557] 36. The composition of item 35, wherein the weight ratio of SG with a molecular weight equal to or greater than 966 Daltons in the composition is greater than 1 wt% of the total SG in the composition

[0558] 37. The composition according to item 35, wherein the weight ratio of SG having a molecular weight equal to or greater than 966 Daltons in the total SG in the composition is between 30 and 50%.

[0559] 38. The composition of any one of items 35-37, wherein the one or more SGs having a molecular weight equal to or greater than 966 Daltons are selected from related SG#2, related SG#5, RU2, RT, RW, RW2, RW3, RU, SG-12, RH, RJ, RK, RK2, SG-Unk4, SG-Unk5, RD, RI, RL, RI3, SG-Unk6, RQ, RI2, RQ2, RQ3, RT1, related SG#4, RV2, RV, RY, RN, RM, 15α-OH RM, RO and RO2.

[0560] 39. The composition of item 1, comprising one or more SGs having a molecular weight equal to or greater than 981 Daltons.

[0561] 40. The composition of item 39, wherein the weight ratio of SG having a molecular weight equal to or greater than 981 Daltons in the composition is between 30 and 50% of the total SG in the composition.

[0562] 41. The composition of any one of items 39-40, wherein the one or more SGs having a molecular weight equal to or greater than 981 Daltons are selected from related SG#2, related SG#5, RU2, RT, RW, RW2, RW3, RU, SG-12, RH, RJ, RK, RK2, SG-Unk4, SG-Unk5, RD, RI, RL, RI3, SG-Unk6, RQ, RI2, RQ2, RQ3, RT1, related SG#4, RV2, RV, RY, RN, RM, 15α-OH RM, RO and RO2.

[0563] 42. The composition of item 1, comprising one or more SGs having a molecular weight equal to or greater than 1097 Daltons.

[0564] 43. The composition of item 42, wherein the weight ratio of SG having a molecular weight equal to or greater than 1097 Daltons in the composition is between 5 and 20% of the total SG in the composition.

[0565] 44. The composition of any of items 42-43, wherein the one or more SGs having a molecular weight equal to or greater than 1097 Daltons are selected from RU2, RT, RW, RW2, RW3, RU, SG-12, RH, RJ, RK, RK2, SG-Unk4, SG-Unk5, RD, RI, RL, RI3, SG-Unk6, RQ, RI2, RQ2, RQ3, RT1, related SG#4, RV2, RV, RY, RN, RM, 15α-OH RM, RO and RO2.

[0566] 45. The composition of item 1, comprising one or more SGs having a molecular weight equal to or greater than 1111 Daltons.

[0567] 46. ​​The composition of item 45, wherein the weight ratio of SG having a molecular weight equal to or greater than 1111 Dalton in the composition is between 4 and 20% of the total SG in the composition.

[0568] 47. The composition of any one of items 45-46, wherein the one or more SGs having a molecular weight equal to or greater than 1111 Daltons are selected from SG-12, RH, RJ, RK, RK2, SG-Unk4, SG-Unk5, RD, RI, RL, RI3, SG-Unk6, RQ, RI2, RQ2, RQ3, RT1, related SG#4, RV2, RV, RY, RN, RM, 15α-OHRM, RO and RO2.

[0569] 48. The composition of item 1, comprising one or more SGs having a molecular weight equal to or greater than 1127 Daltons.

[0570] 49. The composition of item 48, wherein the weight ratio of SG having a molecular weight equal to or greater than 1127 Daltons in the composition is between 2 and 15% of the total SG in the composition.

[0571] 50. The composition of any one of items 48-49, wherein the one or more SGs having a molecular weight equal to or greater than 1127 Daltons are selected from RD, RI, RL, RI3, SG-Unk6, RQ, RI2, RQ2, RQ3, RT1, related SG#4, RV2, RV, RY, RN, RM, 15α-OH RM, RO and RO2.

[0572] 51. The composition of item 1, comprising one or more SGs having a molecular weight equal to or greater than 1259 Daltons.

[0573] 52. The composition of item 51, wherein the weight ratio of SG having a molecular weight equal to or greater than 1259 Daltons in the composition is between 2 and 15% of the total SG in the composition.

[0574] 53. The composition of any one of items 51-52, wherein the one or more SGs having a molecular weight equal to or greater than 1259 Daltons are selected from RV2, RV, RY, RN, RM, 15α-OH RM, RO and RO2.

[0575] 54. The composition of item 1, comprising one or more SGs having a molecular weight equal to or greater than 1273 Daltons.

[0576] 55. The composition of item 54, wherein the weight ratio of SG having a molecular weight equal to or greater than 1273 Daltons in the composition is between 0.3 and 2% of the total SG in the composition.

[0577] 56. The composition of any one of items 54-55, wherein the one or more SGs having a molecular weight equal to or greater than 1273 Daltons are selected from RN, RM, 15α-OH RM, RO and RO2.

[0578] 57. The composition of item 1, comprising one or more SGs having a molecular weight equal to or greater than 1289 Daltons.

[0579] 58. The composition of item 57, wherein the weight ratio of SG having a molecular weight equal to or greater than 1289 Daltons in the composition is between 0.3 and 2% of the total SG in the composition.

[0580] 59. The composition of any one of items 57-58, wherein the one or more SGs having a molecular weight equal to or greater than 1289 Daltons are selected from RM, 15α-OH RM, RO and RO2.

[0581] 60. The composition of item 1, comprising one or more SGs having a molecular weight equal to or greater than 1305 Daltons.

[0582] 61. The composition of item 60, wherein the weight ratio of SG having a molecular weight equal to or greater than 1305 Daltons in the composition is between 0.2 and 1.5% of the total SG in the composition.

[0583] 62. The composition of any one of items 60-61, wherein the one or more SGs having a molecular weight equal to or greater than 1305 Daltons are selected from 15α-OH RM, RO and RO2.

[0584] 63. The composition of item 1, comprising one or more SGs having a molecular weight equal to or greater than 1435 Daltons.

[0585] 64. The composition of item 63, wherein the weight ratio of SG having a molecular weight equal to or greater than 1405 Daltons in the composition is between 0.2 and 1.5% of the total SG in the composition.

[0586] 65. The composition of any one of items 63-64, wherein the one or more SGs having a molecular weight equal to or greater than 1435 Daltons are selected from RO and RO2.

[0587] Other ingredients

[0588] 66. The composition of any one of items 1-65, further comprising one or more non-SG sweeteners.

[0589] 67. The composition of item 66, wherein the non-SG sweetener comprises one or more of the following substances: cyclamate and its salts, sucralose, aspartame, saccharin and its salts, stevia (Truvia TM ), rebaudioside A, xylitol, acesulfame potassium, neotame, N-[N-[3-(3-hydroxy-4-methoxyphenyl)propyl]-α-aspartyl]-L-phenylalanine-1-methyl ester (hereinafter abbreviated as "ANS9801"), glycyrrhizic acid, thaumatin, monellin and combinations thereof.

[0590] 68. The composition of item 66, wherein the non-SG sweetener comprises one or more carbohydrate sweeteners and / or one or more non-carbohydrate sweeteners.

[0591] 69. The composition of item 68, wherein the one or more carbohydrate sweeteners are selected from sucrose, glyceraldehyde, dihydroxyacetone, erythrose, threose, erythrulose, arabinose, lyxose, ribose, xylose, ribulose, xylulose, allose, altrose, galactose, glucose, gulose, idose, mannose, talose, fructose, psicose, sorbose, tagatose, mannoheptulose, sedoheptulose, octolose, fucose, rhamnose, arabinose, sialose, and combinations thereof.

[0592] 70. The composition of any one of items 1-69, further comprising one or more salts.

[0593] 71. The composition of item 70, wherein the salt comprises one or more SG salts.

[0594] 72. The composition of item 71, wherein the one or more SG salts comprise a salt of STB.

[0595] 73. The composition of item 71, wherein the one or more SG salts comprise a salt of RB.

[0596] 74. The composition of any one of items 70-73, wherein the salt comprises NaCl and / or KCl.

[0597] 75. The composition of any one of items 1-74, wherein the composition has increased solubility in water or a water / alcohol solution, wherein the composition is stable in water or a water / alcohol solution for greater than 1, 2, 5, 10, 15, 20, 25 or 30 days.

[0598] 76. The composition of item 75, wherein the solubility in water or water / alcohol solution is ≥1, ≥2, ≥3, ≥5, ≥10, ≥15, ≥20, ≥25, ≥30, ≥35, ≥40, ≥45, ≥50, ≥55, or ≥60 g / 100.

[0599] 77. The composition of any one of items 75-76, wherein the alcohol is selected from methanol, ethanol, propanol, isopropanol, n-butanol, sec-butanol, isobutanol, tert-butanol, n-pentanol, sec-pentanol, isopentanol and neopentyl alcohol.

[0600] 78. The composition of any one of items 75-77, wherein the water or water / alcohol solution is less than 60 vol%, less than 50 vol%, less than 40 vol%, less than 30 vol%, less than 20 vol%, less than 10 vol%, less than 5 vol%, less than 2 vol% or less than 1 vol% alcohol.

[0601] 79. The composition of any one of items 1-78, wherein the composition is stable in water or a water / alcohol solution at between 0 and 25°C, between 5 and 24°C, between 10 and 23°C, or between 15 and 22°C.

[0602] 80. The composition of any one of items 1-79, wherein the composition is stable in water or a water / alcohol solution at room or ambient temperature.

[0603] 81. The composition of any one of items 1-80, wherein the composition is in an amorphous form, a crystalline form, or a mixture thereof.

[0604] 82. The composition of any one of items 1-81, wherein the composition comprises trace amounts or undetectable amounts of non-SG off-flavor components.

[0605] consumer goods

[0606] 83. An oral consumable composition comprising the composition of any one of items 1-82.

[0607] 84. The orally consumable composition of item 83, wherein the orally consumable composition is a sweetener.

[0608] 85. The orally consumable composition of item 83, wherein the orally consumable composition is a flavoring agent.

[0609] Production method

[0610] 86. A method for preparing a composition having enhanced solubility in aqueous solution as described in any one of items 1 to 82, comprising the steps of: (1) mixing SG or the composition with water to form a mixture, (2) heating the mixture until the mixture is completely dissolved to obtain a clear solution, (3) cooling to ambient temperature, and (4) spray drying the solution.

[0611] 87. The method according to item 86, wherein the mixture is heated to 40-100°C.

[0612] How to use

[0613] 88. A method for increasing the sweetness of an orally consumable composition, comprising the step of adding an effective amount of the composition of any one of items 1-82 to the orally consumable composition.

[0614] 89. A method for increasing the taste or flavor of an orally consumable composition, comprising the step of adding an effective amount of the composition of any one of items 1-82 to the orally consumable composition.

[0615] 90. A composition comprising one or more SGs, wherein the SG has a parent structure of formula II or formula III; wherein R1 and R2 are respectively selected from substituents of glucosyl (G), rhamnosyl (R), xylosyl (X), deoxyglucosyl (dG), fructosyl (F), arabinosyl (A), galactosyl (Ga) or any combination of the above groups, and wherein the number of glucosyl groups is equal to or greater than 4.

[0616] 91. The composition of item 90, wherein the number of rhamnosyl groups is equal to or greater than 1.

[0617] 92. The composition of item 90, wherein the number of xylosyl groups is equal to or greater than 1.

[0618] 93. The composition of item 90, wherein the number of deoxyglucosyl groups is equal to or greater than 1.

[0619] 94. The composition of item 90, wherein the number of fructosyl groups is equal to or greater than 1.

[0620] 95. The composition of item 90, wherein the number of arabinosyl groups is equal to or greater than 1.

[0621] 96. The composition of item 90, wherein the number of galactosyl groups is equal to or greater than 1.

[0622] 97. The composition of any one of items 90-96, wherein the one or more SGs are selected from related SG#2, related SG#5, RU2, RT, RW, RW2, RW3, RU, SG-12, RH, RJ, RK, RK2, SG-Unk4, SG-Unk5, RD, RI, RL, RI3, SG-Unk6, RQ, RI2, RQ2, RQ3, RT1, related SG#4, RV2, RV, RY, RN, RM, 15α-OH RM, RO and RO2.

[0623] 98. The composition of any one of items 90-97, wherein the total SG content is greater than 80 wt% of the composition.

[0624] 99. The composition of any one of items 90-97, wherein the total SG content is greater than 90 wt% of the composition.

[0625] 100. The composition of any one of items 90-99, wherein the content of one or more SGs is 0.1-99.9 wt% of the total SGs in the composition.

[0626] 111. The composition of any one of items 90-99, wherein the content of one or more SGs is 1-30 wt% of the total SGs in the composition.

[0627] 112. The composition of any one of items 90-99, wherein the content of one or more SGs is 6-23 wt% of the total SGs in the composition.

[0628] 113 The composition of any one of items 90-112, wherein RD is 1.0-10.0 wt% of the total SG in the composition.

[0629] 114. The composition of any one of items 90-112, wherein RD is 2.0-8.0 wt% of the total SG in the composition.

[0630] 115. The composition of any one of items 90-112, wherein RO is 0.2-1.5 wt% of the total SG in the composition.

[0631] 116. The composition of any one of items 90-112, wherein RK is 1-5 wt% of the total SG in the composition.

[0632] 117. The composition of any one of items 90-112, wherein RV is 0-0.6 wt% of the total SG in the composition.

[0633] 118. The composition of any one of items 90-112, wherein RT is 0-0.9 wt% of the total SG in the composition.

[0634] 119. The composition of any one of items 90-112, wherein RN is 0-0.3 wt% of the total SG in the composition.

[0635] 120. The composition of any one of items 90-112, wherein RM is 0-0.4 wt% of the total SG in the composition.

[0636] 121. The composition of any one of items 90-112, wherein RJ is 0-0.3 wt% of the total SG in the composition.

[0637] 122. The composition of any one of items 90-112, wherein RW is 0-0.4 wt% of the total SG in the composition.

[0638] 123. The composition of any one of items 90-112, wherein RU2 is 0-0.5 wt% of the total SG in the composition.

[0639] 124. The composition of any one of items 90-112, wherein RY is 0-0.3 wt% of the total SG in the composition.

[0640] 125. The composition of any one of items 90-112, wherein RI is 0-0.3 wt% of the total SG in the composition.

[0641] 126. The composition of any one of items 90-112, wherein RV2 is 0-0.5 wt% of the total SG in the composition.

[0642] 127. The composition of any one of items 90-112, wherein RK2 is 0-0.5 wt% of the total SG in the composition.

[0643] 128. The composition of any one of items 90-112, wherein RH is 0-0.3 wt% of the total SG in the composition.

[0644] 129. A composition comprising RA and the composition described in items 90-128.

[0645] 130. The composition of item 129, wherein RA is 15-50 wt% of the total SG in the composition.

[0646] 131. The composition of item 129, wherein RA is 25-35 wt% of the total SG in the composition.

[0647] 132. The composition described in items 129-131, further comprising ST.

[0648] 133. The composition of item 132, wherein ST is 20-70 wt% of the total SG in the composition.

[0649] 134. The composition of item 132, wherein ST is 20-45 wt% of the total SG in the composition.

[0650] 135. A sweetener composition comprising the composition of any one of items 90-134.

[0651] 136. The sweetener composition of item 135, wherein the sweetener composition is dissolved in an aqueous solution.

[0652] 137. The sweetener composition of item 136, wherein the sweetener composition is present in the solution at a concentration of less than 1500 ppm, less than 1000 ppm, less than 700 ppm, less than 400 ppm or less than 200 ppm.

[0653] 138. The sweetener composition of item 137, wherein the sweetener composition is present in solution at a concentration of at least 100 ppm.

[0654] 139. The sweetener composition of items 135-138, wherein the sweetener composition has improvements in lingering sweetness and upfront sweetness.

[0655] 140. A flavor composition comprising any one of the compositions described in items 90-134.

[0656] 141. The flavor composition of item 140, wherein the flavor composition is dissolved in an aqueous solution.

[0657] 142. The flavor composition of item 141, wherein the flavor composition is present in the solution at a concentration of 5-10 ppm.

[0658] 143. The flavor composition described in items 140-142, wherein the flavor composition has enhanced sweetness.

[0659] 144. A flavor composition comprising one or more SGs as described in items 90-97.

[0660] 145. The flavor composition of item 144, wherein the total content of SG is 50-90 wt % of the flavor composition.

[0661] 146. The flavor composition of item 144 or 145, wherein the content of RD is 0.2-9 wt % of the flavor composition.

[0662] 147. The flavor composition of item 144 or 145, wherein the content of RM is 0.1-4.0 wt% of the flavor composition.

[0663] 148. The flavor composition of item 144 or 145, wherein the content of RU is 0.1-3.0 wt% of the flavor composition.

[0664] 149. The flavor composition described in items 144-148, further comprising RA and STV.

[0665] 150. The flavor composition of item 149, wherein the content of RA is 20-30 wt % of the flavor composition.

[0666] 151. The flavor composition of item 149, wherein the content of STV is 8-40 wt % of the flavor composition.

[0667] 152. The flavor composition described in items 144-151 further comprising RF, RC, Dulc A, RB and STB.

[0668] 153. The flavor composition described in items 144-152, wherein the flavor composition is dissolved in an aqueous solution.

[0669] 154. The flavor composition of item 153, wherein the flavor composition is present in the solution at a concentration of less than 60 ppm, less than 70 ppm, less than 75 ppm, less than 100 ppm, less than 200 ppm or less than 300 ppm.

[0670] 155. Any of the flavor compositions described in items 144-154, wherein the flavor composition has increased sweetness.

[0671] 156. A composition comprising two groups of SGs, the first group of SGs comprising one or more SGs selected from any one of items 90-97, and the second group of SGs comprising one or more SGs selected from the group consisting essentially of RA, RB, steviol glycosides, RC, RD, RM or a combination thereof.

[0672] 157. The composition of item 156, wherein the weight ratio of the first group SG to the second group SG is: 1:99, 2:98, 3:97, 4:96; 5:95; 6:94; 7:93; 8:94; 9:91; 10:90; 11:89; 12:88; 13:87; 14:86; 15:85; 16:84; 17:83; 18:82; 19:81; 20:80; 21:79; 22:78; 23:77; 24:76; 25:75; 26:74; 27:73; 28:72; 29:71; 30:70; 31:69; 32:68; 33:67; 34:66; 35:65; 36:64; 37:63; 38:62; 39:61; 40:60; 41:59; 42:58; 43:57; 44:56; 45:55; 46:54; 47:53; 48:52; 49:51; 50:50; 51:49; 52:48; 53:47; 54:45; 55:45; 56:44; 57:43; 58:42; 59:41; 60:40; 61:39; 62:38; 63:37; 64:36; 65:35; 66:37; 67:33; 68:32; 69:31; 70:30; 71:29; 72:28; 73:27; 74:26; 75:25; 76:24; 77:23; 78:22; 79:21; 80:20; 81:19;

[0679] 82:18; 83:17; 84:16; 85:15; 86:14; 87:13; 88:12; 89:11; 90:10; 91:9; 92:8; 93:7; 94:6; 95:5; 96:4; 97:3; 98:2or 99:1.

[0680] 158. A composition comprising the SGs listed in Table 16, wherein the amount of each SG in the composition is within 50%, 40%, 30%, 10%, 5%, 4%, 3%, 2% or 1% of the amount listed in the table.

[0681] 159. A composition comprising the SGs listed in Table 17, wherein the amount of each SG in the composition is within 50%, 40%, 30%, 10%, 5%, 4%, 3%, 2% or 1% of the amount listed in the table.

[0682] 160. A composition comprising the SGs listed in Table 18, wherein the amount of each SG in the composition is within 50%, 40%, 30%, 10%, 5%, 4%, 3%, 2% or 1% of the amount listed in the table.

[0683] 161. A composition comprising the SGs listed in Table 19, wherein the amount of each SG in the composition is within 50%, 40%, 30%, 10%, 5%, 4%, 3%, 2% or 1% of the amount listed in the table.

[0684] 162. A composition comprising the SGs listed in Table 20, wherein the amount of each SG in the composition is within 50%, 40%, 30%, 10%, 5%, 4%, 3%, 2% or 1% of the amount listed in the table.

[0685] 163. A composition comprising the SGs listed in Table 21, wherein the amount of each SG in the composition is within 50%, 40%, 30%, 10%, 5%, 4%, 3%, 2% or 1% of the amount listed in the table.

[0686] 164. A composition comprising the SGs listed in Table 22, wherein the amount of each SG in the composition is within 50%, 40%, 30%, 10%, 5%, 4%, 3%, 2% or 1% of the amount listed in the table.

[0687] 165. A composition comprising the SGs listed in Table 23, wherein the amount of each SG in the composition is within 50%, 40%, 30%, 10%, 5%, 4%, 3%, 2% or 1% of the amount listed in the table.

[0688] 166. A composition comprising the SGs listed in Table 24, wherein the amount of each SG in the composition is within 50%, 40%, 30%, 10%, 5%, 4%, 3%, 2% or 1% of the amount listed in the table.

[0689] 167. A composition comprising the SGs listed in Table 25, wherein the amount of each SG in the composition is within 50%, 40%, 30%, 10%, 5%, 4%, 3%, 2% or 1% of the amount listed in the table.

[0690] 168. A composition comprising the SGs listed in Table 26, wherein the amount of each SG in the composition is within 50%, 40%, 30%, 10%, 5%, 4%, 3%, 2% or 1% of the amount listed in the table.

[0691] 169. A combined composition comprising the SGs of Tables 16-23, wherein the amount of each SG in the combined composition is within 50%, 40%, 30%, 10%, 5%, 4%, 3%, 2% or 1% of the combined amount combined in a ratio of 1:1:1:1:1:1:1:1:1.

[0692] 170. A combined composition comprising the SGs of Tables 24-26, wherein the amount of each SG in the combined composition is within 50%, 40%, 30%, 10%, 5%, 4%, 3%, 2% or 1% of the combined amount combined in a 1:1:1 ratio.

[0693] 171. A combined composition comprising SG A1-1, A1-2, A1-3, A1-4 and A1-5 of Table 52, wherein the amount of each SG in the combined composition is within 50%, 40%, 30%, 10%, 5%, 4%, 3%, 2% or 1% of the combined amount combined in a ratio of 1:1:1:1:1.

[0694] 172. A combined composition comprising SG A2-1, A2-2, A2-3, A2-4 and A2-5 of Table 52, wherein the amount of each SG in the combined composition is within 50%, 40%, 30%, 10%, 5%, 4%, 3%, 2% or 1% of the combined amount combined in a ratio of 1:1:1:1:1.

[0695] 173. The composition described in any of the above items, wherein the one or more SGs with high molecular weight account for 0.1-99.9 wt% of the total SG in the composition.

[0696] 174. The composition described in any of the above items, wherein the one or more SGs with high molecular weight account for 4-20 wt% of the total SG in the composition.

[0697] 175. The composition described in any of the above items, wherein the one or more SGs with high molecular weight account for 3-20 wt% of the total SG in the composition.

[0698] 176. The composition described in any of the above items, wherein the one or more SGs with high molecular weight account for 0.3-2 wt% of the total SG in the composition.

[0699] 177. A composition comprising SG in Table A, which comprises RA and any of the compositions described above.

[0700] 178. The composition of item 177, wherein RA is 15-50 wt % of the total SG in the composition.

[0701] 179. The composition of item 178, wherein RA is 20-30 wt% of the total SG in the composition.

[0702] 180. The composition of any of the above items, further comprising ST.

[0703] 181. The composition described in any of the above items, wherein ST is 15-30 wt% of the total SG in the composition.

[0704] 182. The composition of any of the above, wherein the composition has an improved taste profile, including aftertaste, bitterness and / or lingering, compared to a composition not comprising any of the above compositions.

[0705] 183. The composition of any of the above, wherein the composition has increased solubility compared to a composition not comprising any of the above compositions.

[0706] 184. An oral consumable composition as described in any of the above items, wherein one or more SGs having a molecular weight greater than 965 Daltons account for at least 5ppm, 10ppm, 20ppm, 30ppm, 40ppm, 50ppm, 60ppm, 70ppm, 80ppm, 90ppm, 100ppm, 150ppm, 200ppm, 300ppm, 400ppm, 600ppm, 800ppm, 1000ppm or 1200ppm of the total amount of the oral consumable composition.

[0707] 185. A method for improving the taste profile of a SG composition including aftertaste, bitterness and / or lingering taste, comprising the step of adding an effective amount of any of the above-described compositions to the SG composition.

[0708] 186. A method for improving the solubility of a SG composition in an aqueous solution, comprising the step of adding an effective amount of any of the above compositions to the SG composition.

[0709] 187. The method of item 185 or 186, wherein the SG composition comprises RA and / or ST.

[0710] 188. The method for preparing the SG composition described in any of the above items also includes a step of removing non-steviol odor compounds.

[0711] 189. The method of item 188, wherein the off-flavor compound has a bitter taste.

[0712] 190. The method for preparing the composition described in any one of items 1 to 41 comprises the following steps: dissolving a crude extract in a first ethanol aqueous solution to form a mixture, heating the mixture until the mixture becomes a solution; cooling the solution to ambient temperature; separating the supernatant and the precipitate of the solution; drying the supernatant to form a powder; dissolving the powder in water to form a second solution; treating the second solution with a macroporous resin to obtain a material; and desorbing the material with a second ethanol aqueous solution.

[0713] 191. The method described in item 190, wherein the concentration of the second ethanol aqueous solution is greater than 0 and less than 50wt%, preferably 20-50wt%, and more preferably 25-35wt%.

[0714] 192. The method described in item 190, wherein the concentration of the second ethanol aqueous solution is 50-100wt%, preferably 60-80wt%, and more preferably 65-75wt%.

[0715] 193. A composition as described in any of the above items, wherein the composition comprises 20-27wt% RA, 8-14wt% RC, 1.5-8wt% RD, 0.9-4.3wt% RM, 1.4-2.6wt% RF, 0.4-1.2wt% RE, 0.5-1.4wt% RN, 14-34wt% ST, 0.4-1.1wt% rubusoside, 0.4-1.2wt% dulcoside A, wherein total steviol glycosides are 77-96wt% of the total composition.

[0716] 194. A composition as described in any of the above items, wherein the composition comprises 20-35wt% RA, 5-15wt% RC, 1-10wt% RD, 0.5-10wt% RM, 1-4wt% RF, 0.1-2wt% RE, 0.1-2wt% RN, 14-40wt% ST, 0.1-2wt% rubusoside, 0.1-2wt% dulcoside A, wherein total steviol glycosides are 70-99wt% of the total composition.

[0717] 195. A composition as described in any of the above items, wherein the composition comprises 20-30wt% RA, 5-15wt% RC, 1-10wt% RD, 0.5-10wt% RM, 1-4wt% RF, 0.1-2wt% RE, 0.1-2wt% RN, 14-40wt% ST, 0.1-2wt% rubusoside, 0.1-2wt% dulcoside A, wherein total steviol glycosides are 70-99wt% of the total composition.

[0718] 196. A composition as described in any of the above items, wherein the composition comprises 20-30wt% RA, 5-15wt% RC, 1-10wt% RD, 0.5-10wt% RM, 1-4wt% RF, 0.3-0.9wt% RE, 0.1-2wt% RN, 14-40wt% ST, 0.1-2wt% rubusoside, 0.1-2wt% dulcoside A, wherein total steviol glycosides are 70-99wt% of the total composition.

[0719] 197. A composition as described in any of the above items, wherein the composition comprises 20-30wt% RA, 5-15wt% RC, 1-10wt% RD, 0.5-10wt% RM, 1-4wt% RF, 0.3-0.9wt% RE, 0.1-2wt% RN, 15-30wt% ST, 0.1-2wt% rubusoside, 0.1-2wt% dulcoside A, wherein total steviol glycosides are 70-99wt% of the total composition.

[0720] 198. A composition as described in any of the above items, wherein the composition comprises 20-30wt% RA, 5-15wt% RC, 1-10wt% RD, 0.5-10wt% RM, 1-4wt% RF, 0.3-0.9wt% RE, 0.1-2wt% RN, 20-35wt% ST, 0.1-2wt% rubusoside, 0.1-2wt% dulcoside A, wherein total steviol glycosides are 70-99wt% of the total composition.

[0721] 199. A composition as described in any of the above items, wherein the composition comprises 15-40wt% RA, 1-20wt% RC, 0.1-15wt% RD, 0.1-15wt% RM, 0.1-10wt% RF, 0.1-3wt% RE, 0.1-3wt% RN, 10-45wt% ST, 0.1-3wt% rubusoside, 0.1-3wt% dulcoside A, wherein total steviol glycosides account for 70-99wt% of the total composition.

[0722] 200. A composition as described in any of the above items, wherein the composition comprises 15-45wt% RA, 0.1-25wt% RC, 0.1-20wt% RD, 0.1-20wt% RM, 0.1-15wt% RF, 0.1-4wt% RE, 0.1-4wt% RN, 5-50wt% ST, 0.1-4wt% rubusoside, 0.1-4wt% dulcoside A, wherein total steviol glycosides account for 70-99wt% of the total composition.

[0723] 201. A composition according to any of the above items, wherein the composition comprises 15-50wt% RA, 0.1-30wt% RC, 0.1-25wt% RD, 0.1-25wt% RM, 0.1-20wt% RF, 0.1-5wt% RE, 0.1-5wt% RN, 5-55wt% ST, 0.1-5wt% rubusoside, 0.1-5wt% dulcoside A, wherein total steviol glycosides account for 70-99wt% of the total composition.

[0724] 202. The composition of any of the above items, wherein the composition comprises 25-30wt% RA, 7-12wt% RC, 5-10wt% RD, 5-10wt% RM, 2-4wt% RF, 1-2wt% RE, 1-2wt% RN, 20-35wt% ST, 1-2wt% rubusoside, 1-2wt% dulcoside A, wherein total steviol glycosides are 70-99wt% of the total composition.

[0725] 203. A composition according to any of the above items, wherein the composition comprises 25-30wt% RA, 7-10wt% RC, 7-10wt% RD, 7-10wt% RM, 3-4wt% RF, 1-2wt% RE, 1-2wt% RN, 25-35wt% ST, 1-2wt% rubusoside, 1-2wt% dulcoside A, wherein total steviol glycosides are 70-99wt% of the total composition.

[0726] 204. The composition of any of the above items, wherein the composition comprises 20-30wt% RA, 0.3-0.9wt% RE and 15-30wt% ST or 20-35wt% ST.

[0727] The present invention will be further described with reference to the following non-limiting examples. It will be apparent to those skilled in the art that various changes may be made to the embodiments without departing from the scope of the present invention. Therefore, the scope of the present invention should not be limited to the embodiments described in the present invention, which are only limited by the embodiments described in the claims and the equivalent embodiments of those embodiments. Unless otherwise indicated, all percentages are weight percentages.

[0728] Example

[0729] Example 1 General method for preparing SG with improved solubility

[0730] SG or SG was mixed with water. The mixture was then heated to 60-70°C under stirring until the mixture was completely dissolved to obtain a clear solution. The mixture was then stirred at 60-70°C for another 30 min and then cooled to ambient temperature. The solution was then spray dried using L-117 (Beijing Laiheng Technology and Trade Co., Ltd.) (inlet temperature: 135°C, outlet temperature: 90°C, feed rate: 200 mL / h; pressure: 1.8 kPa) to obtain a white powder product (yield = 95 wt%).

[0731] Different SG or SG compositions were prepared using the raw materials listed in Table 1. Materials RA60, RA80 and RA97 are commercially available from Sweet Green Fields. These raw materials were used in Examples 2-6 as shown below.

[0732] Table 1

[0733]

[0734] Example 2 Evaluation of the solubility of SG or SG composition with improved solubility

[0735] The solubility of the SG or SG composition listed in Table 1 was evaluated according to the following steps. The raw materials listed in Table 1 were treated and spray-dried according to Example 1, and then dissolved in water at a weight ratio of 1:10, and the mixture was heated to 70°C until all the solids were dissolved to obtain an aqueous solution. The solution was cooled to ambient temperature and the stability of the solution (i.e., the time to precipitation) was observed. The solubility results of the treated SG or SG composition are shown in Table 2.

[0736] Table 2

[0737]

[0738]

[0739] *RA7

[0740] **RA80

[0741] ***RA60

[0742] The results of Example 2 show that the specific ratios of the treated SG (samples 1-10) have improved solubility in aqueous solution compared to rebaudioside B and D, and rebaudioside A, B and D alone (samples 11-14). RA, RB, RD and 50:50 RB / RD have poor solubility, while the steviol glycoside mixture containing RA, RB and RD (wherein RB is 0-20%, RD is 0-15% and RB+RD <30%) has the greatest improvement in solubility.

[0743] Example 3 Evaluation of the solubility of SG with improved solubility

[0744] Among them, RA:RB:RD=78 / 15 / 7 (sample 4) The mixture in Table 2 which was first heat-treated and spray-dried according to Example 1 was made into aqueous solutions of different concentrations, and the maximum solubility, temperature and stability were determined and summarized in Table 3.

[0745] Table 3

[0746]

[0747] The results showed that the solubility of the mixture had an upper limit of 30 g / 100 ml and the stability of the resulting 30% wt / wt solution was greater than 2 days at ambient temperature.

[0748] Example 4 Evaluation of the solubility of SG compositions with improved solubility

[0749] The SG with further improved solubility was first heat treated and spray dried according to Example 1, and the stability at different solution concentrations was evaluated, as shown in Table 4.

[0750] Table 4

[0751]

[0752] The results showed that batch CT001-131108 (comprising a SG composition of RA:RB:RD=80 / 10 / 6) was stable in aqueous solution at a concentration of 60 g / 100 g water for more than 30 days.

[0753] Example 5 Powder XRD of SG Composition with Improved Solubility

[0754] The SG compound with improved solubility, which was first heat treated and spray dried according to Example 1, was subjected to powder XRD. The HPLC results are shown in Table 5. HPLC was performed using a Supelcosil LC-NH2 column at 40°C with a mobile phase of 80:20 ACN / water adjusted to pH 3 with 85% phosphoric acid. The flow rate was adjusted so that the retention time of the standard RA (Wako Corporation) was 21 min.

[0755] Table 5

[0756]

[0757] From powder XRD ( Figure 1 and 2 ) It can be seen that the spectrum of the steviol glycoside composition with improved solubility shows an amorphous product rather than a polymorph, and is therefore different from the soluble form described in the public literature.

[0758] Example 6: Using high purity RA, RB, RD and stevioside (SS) mixed with several SG

[0759] The steviol glycosides that were not heat treated and spray dried according to Example 1 were mixed with water and heated to 70° C. to obtain the following mixtures. The composition, mixture concentration, solubility and stability of each steviol glycoside are shown in Table 6.

[0760] Table 6

[0761]

[0762] SS shows some improvement in solubility for RA. For the RA / RB system, the solubility of RA is minimized until the proportion of RB reaches 10% or more. For the RA / RD system, the solubility of RA is minimized until the proportion of RD reaches 15% or more.

[0763] Example 7 Additional RA / RB stability data

[0764] RA-RB-1 and RA-RB-3 were prepared according to the current spray-drying method and the concentration-dependent solubility was determined.

[0765] Table 7

[0766]

[0767] Table 8

[0768]

[0769] As shown above, when the concentration of RA-RB-1 reached 10%, the solution remained stable for more than 30 days. The initial solubility of RA-RB-3 reached 20%, but was less stable.

[0770] Example 8 Melting Point Determination

[0771] The melting points of untreated and treated SG and SG compositions were determined and are disclosed in Table 9. Melting points were determined using X-4 (Beijing Tektronix Instrument Co., Ltd.) with a heating rate of 1°C / min.

[0772] Table 9

[0773]

[0774]

[0775] The solubility of the treated samples was lower than that of RA and untreated samples, indicating that positive changes occurred in the structure of the treated compositions.

[0776] Example 9

[0777] An analytical methodology was performed to evaluate the SG present in a number of different mother liquor samples. Figure 3 Shown is a schematic overview of the analytical methodology used to determine the reaction products formed from the hydrolysis of the SG starting material.

[0778] raw material

[0779] Reference standards of steviol glycosides (Reb A, Reb B, Reb C, Reb D, Reb E, Reb F, Reb G, Reb M, Reb N) were provided by Chromadex (LGC, Germany). Solvents and reagents (HLC grade) were provided by VMR (Vienna) or Sigma-Aldrich (Vienna). Davisil Grade 633 (high purity grade silica gel, pore size 200-425 mesh size) was supplied by Sigma-Aldrich (Vienna).

[0780] Sample preparation

[0781] 300 mg of the sample was dissolved in 20 ml of acetonitrile / H2O=9 / 1 (v / v).

[0782] HPLC method

[0783] The HPLC system consisted of an Agilent 1100 system (autosampler, ternary gradient pump, column oven, WD-UV / VIS detector, DAD-UV / VIS detector) connected in series with an Agilent mass spectrometer (ESI-MS quadrupole G1956A VL). For HPLC analysis, 150 mg of the corresponding sample was dissolved in acetonitrile (1 ml) and filled up to 10 ml with water.

[0784] The sample was separated at 0.8 ml / min in a Phenomenex Synergi Hydro-RP (150 x 3 mm) and then gradient eluted at 45° C. through a Macherey-Nagel Nucleosil 100-7C18 (250 x 4.6 mm). Mobile phase A consisted of 0.01 molar NH4-acetate buffer (native pH) and 0.1% acetic acid, 0.05% trimethylamine and 0.001% dichloromethane. Mobile phase B consisted of 0.01 molar NH4-acetate buffer (native pH), acetonitrile (1 / 9 v / v) and 0.1% acetic acid, 0.05% trimethylamine and 0.001% dichloromethane. The gradient started from 22% B and increased linearly to 45% B in 20 min and was retained for another 15 minutes under such conditions. The injection volume was set to 10 μl.

[0785] The detector settings were 210 nm (VWD), 205 and 254 nm (DAD collecting spectra between 200-600 nm) and ESI negative mode TIC m / z 300-1500, fragmentor voltage 200, gain 2 (MS, 300°C, nitrogen 12 l / min, nebulizer set at 50 psig, capillary voltage 4500 V).

[0786] Spectra were quantified using detection at 210 nm. Molecular weight and structural information of each peak was determined using MS-spectroscopy. Non-steviol glycoside peaks were identified using detection at 254 nm.

[0787] Qualitative and quantitative

[0788] Steviol glycosides were identified by comparison with retention times of authentic reference standards and / or evaluation of the resulting mass spectra including interpretation of fragmentation patterns and doubly charged ions caused by the presence of dichloromethane.

[0789] Steviol glycosides were quantified by external standard method. In the absence of reference standards, Reb-A was quantified.

[0790] The maximum calibration range of the reference standard is in the range of 0.1-50 mg / 10 ml (dissolved in acetonitrile / H2O=9 / 1 (v / v)).

[0791] Example 10 Analysis of SG content

[0792] A series of exemplary compositions were analyzed for the content of different SG compounds. The compositions described herein were obtained by extraction of leaves followed by further separation using resins or purification using compositions as raw materials (RA and / or RA / ST purification residues).

[0793] Multiple samples of the exemplary liquid formulations were subjected to HPLC to determine the SG composition of the formulations. The HPLC was calibrated using standards of RA, RB, RC, RD, RE, RF, RG, RM, and RN.

[0794] raw material

[0795] Reference standards of steviol glycosides (Reb A, Reb B, Reb C, Reb D, Reb E, Reb F, Reb G, Reb M, Reb N) were provided by Chromadex (LGC Germany). Solvents and reagents (HLC grade) were provided by VMR (Vienna) or Sigma-Aldrich (Vienna).

[0796] Davisil Grade 633 (high purity grade silica gel, pore size 200-425 mesh size) was supplied by Sigma-Aldrich (Vienna).

[0797] Sample preparation

[0798] 300 mg of the sample was dissolved in 20 ml of acetonitrile / H2O=9 / 1 (v / v).

[0799] HPLC method

[0800] The HPLC system consisted of an Agilent 1100 system (autosampler, ternary gradient pump, column oven, WD-UV / VIS detector, DAD-UV / VIS detector) connected in series with an Agilent mass spectrometer (ESI-MS quadrupole G1956A VL). For HPLC analysis, 150 mg of the corresponding sample was dissolved in acetonitrile (1 ml) and filled up to 10 ml with water.

[0801] The samples were separated at 0.8 ml / min in a Phenomenex Synergi Hydro-RP (150 x 3 mm) and then gradient eluted at 45°C through a Macherey-Nagel Nucleosil 100-7C18 (250 x 4.6 mm).

[0802] Mobile phase A consisted of 0.01 molar NH4-acetate buffer (native pH) and 0.1% acetic acid, 0.05% trimethylamine and 0.001% dichloromethane. Mobile phase B consisted of 0.01 molar NH4-acetate buffer (native pH), acetonitrile (1 / 9 v / v) and 0.1% acetic acid, 0.05% trimethylamine and 0.001% dichloromethane. The gradient started from 22% B and increased linearly to 45% B in 20 min and was retained under such conditions for another 15 minutes. The injection volume was set to 10 μl.

[0803] The detector settings were 210 nm (VWD), 205 and 254 nm (DAD collecting spectra between 200-600 nm) and ESI negative mode TIC m / z 300-1500, fragmentor voltage 200, gain 2 (MS, 300°C, nitrogen 12 l / min, nebulizer set at 50 psig, capillary voltage 4500 V).

[0804] Spectra were quantified using detection at 210 nm. Molecular weight and structural information of each peak was determined using MS-spectroscopy. Non-SG peaks were identified using detection at 254 nm.

[0805] Qualitative and quantitative

[0806] SGs were identified by comparison with retention times of authentic reference standards and / or evaluation of the resulting mass spectra including interpretation of fragmentation patterns and doubly charged ions due to the presence of dichloromethane.

[0807] Steviol glycosides were quantified by external standard method. In the absence of reference standards, Reb-A was quantified.

[0808] The maximum calibration range of the reference standard is in the range of 0.1-50 mg / 10 ml (dissolved in acetonitrile / H2O=9 / 1 (v / v)). Figure 4-6 Shown are steviosides ( Figure 4 ), RA( Figure 5 ) and RD( Figure 6 ) is an exemplary standard diagram.

[0809] Figure 7: is an exemplary peak identification diagram. For singly charged ions: m / z 949 = [MH] -; m / z 787 = [MH-hexose] -; m / z 641 = [MH-hexose-rhamnose / Deoxyhesose] -; and m / z 479 = [MH-hexose-rhamnose / Deoxyhesose-hexose] -; For adduct ions: m / z 701 = m / z 641 + acetic acid; and m / z 736 = m / z 701 + Cl-; For peak identification: molecular weight 950 (ST + 3 glucose + one rhamnose / Deoxyhesose).

[0810] Table 10 shows the SG composition of sample SCJ2017625-26 (commercially available from Sweet GreenFields. Prepared according to the method described in Example 11. It is a powder spray-dried from a 70% ethanol desorption solution). The total SG amount is 95.5% (56.7% + 24.1% + 14.7% = 95.5%). The total percentage of SG obtained by the external standard method using a credible reference standard is 56.7% (including RA, RB, RC, RD, RF, Dulc A, RU, STV and STB). Using Reb-A as a reference standard and mass calibration calculation, the total percentage of SG with a structure identified by ESI-MS obtained by the external standard method is 24.1% (including REBO, REB M, REB N, etc.). The total percentage of SG without an identified structure obtained by the external standard method using Reb-A as a reference standard is 14.7%.

[0811] Figure 8 Shown is the spectrum of 150 mg sample SCJ2017625-26 / 10 ml. Fig. 9 Shown is a chromatogram of the total ion current of sample SCJ2017625-26.

[0812] Table 10 Steviol glycosides in sample SCJ2017625-26 (149.3 mg / 10 ml in sample)

[0813]

[0814]

[0815]

[0816] Table 11 shows the SG composition of sample SCJ20171008 (commercially available from Sweet Green Fields. Prepared according to the method described in Example 11. It is a powder spray dried from a 70% ethanol desorption solution). The total SG content is 95.4%. The total percentage of SG obtained by external standard method using an authentic reference standard is 61.4%. The total percentage of SG with structures identified by ESI-MS obtained by external standard method using Reb-A as a reference standard and mass calibration calculation is 20.0%. The total percentage of SG without identified structures obtained by external standard method using Reb-A as a reference standard is 14.0%.

[0817] Fig.10 Shown is the spectrum of 150 mg sample SCJ20171008 / 10 ml. Fig.11 Shown is a chromatogram of the total ion current of sample SCJ20171008.

[0818] Table 11 Steviol glycosides in sample SCJ20171008 (150.5 mg / 10 ml in sample)

[0819]

[0820]

[0821] Table 12 shows the SG composition of sample SCJ20171105-1 (commercially available from Sweet Green Fields. Prepared according to the method described in Example 11. It is a powder spray dried from a 30% ethanol desorption solution). The total SG content is 102%. The total percentage of SG obtained by external standard method using an authentic reference standard is 62.8%. The total percentage of SG with structures identified by ESI-MS obtained by external standard method using Reb-A as a reference standard and mass calibration calculation is 25.9%. The total percentage of SG without identified structures obtained by external standard method using Reb-A as a reference standard is 12.7%.

[0822] Fig.12 Shown is the spectrum of 150 mg sample SCJ20171105-1. Fig.13 Shown is a chromatogram of the total ion current of sample SCJ20171105-1.

[0823] Table 12 Steviol glycosides in sample SCJ20171105-1 (145.5 mg / 10 ml in sample)

[0824]

[0825]

[0826] Table 13 shows the SG composition of sample SCJ20171009 (commercially available from Sweet Green Fields. Prepared according to the method described in Example 11. It is a powder spray dried from a 70% ethanol desorption solution). The total SG content is 96.4%. The total percentage of SG obtained by external standard method using an authentic reference standard is 59.8%. The total percentage of SG with structures identified by ESI-MS obtained by external standard method using Reb-A as a reference standard and mass calibration calculation is 22.2%. The total percentage of SG without identified structures obtained by external standard method using Reb-A as a reference standard is 14.4%.

[0827] Fig.14 Shown is the spectrum of 150 mg sample SCJ20171009. Fig.15 Shown is a chromatogram of the total ion current of sample SCJ20171009.

[0828] Table 13 Steviol glycosides in sample SCJ20171009 (149.7 mg / 10 ml in sample)

[0829]

[0830]

[0831] Table 14 shows the SG composition of sample SCJ20170220-24 (commercially available from Sweet Green Fields. Prepared according to the method described in Example 11. It is a powder spray dried from a 70% ethanol desorption solution). The total SG content is 95.5%. The total percentage of SG obtained by external standard method using an authentic reference standard is 63.7%. The total percentage of SG with structures identified by ESI-MS obtained by external standard method using Reb-A as a reference standard and mass calibration calculation is 22.1%. The total percentage of SG without identified structures obtained by external standard method using Reb-A as a reference standard is 9.64%.

[0832] Fig.16 Shown is the spectrum of 150 mg sample SCJ20170220-24. Fig.17 Shown is a chromatogram of the total ion current of sample SCJ20170220-24.

[0833] Table 14 Steviol glycosides in sample SCJ20170220-24 (147.2 mg / 10 ml in sample)

[0834]

[0835]

[0836]

[0837] Example 11 SG composition of exemplary samples

[0838] Multiple samples of the exemplary liquid formulations were subjected to HPLC to determine the SG composition of the formulations. The HPLC was calibrated using standards of RA, RB, RC, RD, RE, RF, RG, RM, and RN.

[0839] raw material

[0840] Reference standards of steviol glycosides (RA, RB, RC, RD, RE, RF, RG, RM, RN) were provided by Chromadex (LGC, Germany). Solvents and reagents (HLC grade) were provided by VMR (Vienna) or Sigma-Aldrich (Vienna).

[0841] Preparation of sample composition No. 1-13

[0842] Air-dried stevia leaves (1 kg) were extracted with distilled water at 45-55°C for 2 hours. The extraction stage was repeated three times. The amount of water in each extraction stage was 5L, 5L and 3L, respectively. The liquid extract was separated from the solid by centrifugation. The filtered supernatant extract was flocculated and the supernatant was separated by centrifugation. The supernatant was passed through a macroporous resin (1L, resin model: T28, purchased from Sunresin new materials Co. Ltd., China), and then desorbed with 3L 65% ethanol / water. The desorption solution was treated with 1L cation exchange resin and 1L anion exchange resin for desalting and decolorization. The ion exchange resin can be all ion exchange resins known to those skilled in the art. Afterwards, the desorption solution was spray-dried into a powder and designated as a crude extract. The crude extract was dissolved in 80% ethanol aqueous solution by weight of 3 times ethanol aqueous solution. The solution was then heated to 75-80°C and stirred for 1 hour. The solution was then cooled and left to stand at 20-25°C for 1 hour. The supernatant and the precipitate were separated by centrifugation. The resulting precipitate is used to produce other stevia extract products, such as RA97. The supernatant is distilled to recover ethanol and then spray-dried into a powder. The powder is dissolved in 10 times its weight of water and treated with a macroporous resin (1L, resin model: T28, purchased from Sunresin newmaterials Co. Ltd., China). The material is desorbed with a mixture of ethanol and water with different mixing ratios. The desorption solution of an ethanol / water mixture with a low mixing ratio (the ratio of ethanol is 0%-50%) such as 3L of 30% ethanol is concentrated and then spray-dried to provide a powder. The powder contains about 4-8% rebaudioside D and 1-4% rebaudioside M. SG composition No.1-9 is such a product. The desorption solution of an ethanol / water mixture with a high mixing ratio (the ratio of ethanol is 50%-100%) such as 3L of 70% ethanol is concentrated and then spray-dried to provide a powder. The powder contains about 1.4% rebaudioside D and 0-0.2% rebaudioside M. The SG compositions No. 10 to No. 13 belong to this product.

[0843] Sample preparation

[0844] 300 mg of the sample was dissolved in 20 ml of acetonitrile / H2O=9 / 1 (v / v).

[0845] HPLC method

[0846] The HPLC system consisted of an Agilent 1100 system (autosampler, ternary gradient pump, column oven, WD-UV / VIS detector, DAD-UV / VIS detector) connected in series with an Agilent mass spectrometer (ESI-MS quadrupole G1956A VL). For HPLC analysis, 150 mg of the corresponding sample was dissolved in acetonitrile (1 ml) and filled up to 10 ml with water.

[0847] The samples were separated at 0.8 ml / min in a Phenomenex Synergi Hydro-RP (150 x 3 mm) and then gradient eluted at 45°C through a Macherey-Nagel Nucleosil 100-7C18 (250 x 4.6 mm).

[0848] Mobile phase A consisted of 0.01 molar NH4-acetate buffer (native pH) and 0.1% acetic acid, 0.05% trimethylamine and 0.001% dichloromethane. Mobile phase B consisted of 0.01 molar NH4-acetate buffer (native pH), acetonitrile (1 / 9 v / v) and 0.1% acetic acid, 0.05% trimethylamine and 0.001% dichloromethane. The gradient started from 22% B and increased linearly to 45% B in 20 min and was retained under such conditions for another 15 minutes. The injection volume was set to 10 μl.

[0849] The detector settings were 210 nm (VWD), 205 and 254 nm (DAD collecting spectra between 200-600 nm) and ESI negative mode TIC m / z 300-1500, fragmentor voltage 200, gain 2 (MS, 300°C, nitrogen 12 l / min, nebulizer set at 50 psig, capillary voltage 4500 V).

[0850] Spectra were quantified using detection at 210 nm. Molecular weight and structural information of each peak was determined using MS-spectroscopy. Non-SG peaks were identified using detection at 254 nm.

[0851] Qualitative and quantitative

[0852] SGs were identified by comparison with retention times of authentic reference standards and / or evaluation of the resulting mass spectra including interpretation of fragmentation patterns and doubly charged ions due to the presence of dichloromethane.

[0853] Steviol glycosides were quantified by external standard method. In the absence of reference standards, Reb-A was quantified.

[0854] The maximum calibration range of the reference standard is in the range of 0.1-50 mg / 10 ml (dissolved in acetonitrile / H2O=9 / 1 (v / v)).

[0855] Tables 15-27 show the SG content in exemplary compositions of the present invention.

[0856] Fig.18 Depicted are the spectra corresponding to the compositions shown in Table 15.

[0857] Table 15 SG No.1 of sample composition (182.3 mg / 10 ml)

[0858]

[0859]

[0860] Table 16 SG No.3 of sample composition (154.4 mg / 10 ml)

[0861]

[0862]

[0863] Table 17 SG No.4 (149.5 mg / 10 ml) of sample composition

[0864]

[0865]

[0866] Table 18 SG No.5 of sample composition (151.4 mg / 10 ml)

[0867]

[0868]

[0869] Table 19 SG No.6 (157.3 mg / 10 ml) of sample composition

[0870]

[0871]

[0872] Table 20 SG No.7 (164.6 mg / 10 ml) of sample composition

[0873]

[0874] 140PIUS-CN200139.D1YBX

[0875]

[0876] Table 21 SG No.8 (156.8 mg / 10 ml) of sample composition

[0877]

[0878]

[0879] Table 22 SG No.9 (156.8 mg / 10 ml) of sample composition

[0880]

[0881]

[0882] Table 23 SG No.10 (150.7 mg / 10 ml) of sample composition

[0883]

[0884]

[0885] Table 24 SG No.11 (160.6 mg / 10 ml) of sample composition

[0886]

[0887]

[0888] Table 25 SG No.12 (166.6 mg / 10 ml) of sample composition

[0889]

[0890]

[0891] Table 26 SG No.13 (165.1 mg / 10 ml) of sample composition

[0892]

[0893]

[0894] Example 12 Taste properties and solubility relative to RA97

[0895] raw material

[0896]

[0897] *Total steviol glycosides (TSG) are all glycosylated derivatives of steviol.

[0898] Solution

[0899] In order to make the TSG content in the solution almost the same, the raw materials were dissolved in deionized water of different concentrations, thus obtaining solutions with almost the same sweetness.

[0900] Sample No. Composition concentration Sample 1 Composition No. 5 of Example 11 830ppm Sample 2 RA97 500ppm

[0901] evaluate

[0902] Six trained expert panels evaluated each sample for sugar-likeness, bitterness, aftertaste and lingering sweetness, with each attribute scored from 0 to 5, with higher scores indicating a stronger perception of that attribute.

[0903]

[0904] in conclusion

[0905] Sample 1 (Composition No. 5 of Example 11) contains more RD and RM than Sample 2 (RA97). It is clear that the taste profile of Composition No. 5 is superior to RA97.

[0906] Long term solubility

[0907] The solubility of Composition No. 5 of Example 11 in deionized water was also evaluated.

[0908] Material concentration Time for clear solution Composition No. 5 of Example 11 10％ >21 days Composition No. 5 of Example 11 30％ >21 days Composition No. 5 of Example 11 50％ >21 days

[0909] Example 13 Data summary of samples of Example 11

[0910] The SG compositions in the samples of Example 11 are listed for the 9 most common SGs (RA, ST, RB, RC, RD, RF, dulcoside-A, rubusoside, STB) and 13 common SGs (RA, ST, RB, RC, RD, RE, RF, RM, RN, RO, dulcoside-A, rubusoside, STB).

[0911] Table 27 Comparison of SG in sample compositions

[0912]

[0913]

[0914] The sample of Example 11 is listed for the percentage of the composition consisting of SG having a molecular weight greater than 965 Daltons.

[0915] Table 28 Comparison of high molecular weight SG in sample compositions

[0916]

[0917]

[0918] Example 14 SG composition of exemplary samples

[0919] In separate analyses, multiple samples of additional exemplary liquid formulations were subjected to HPLC to determine the SG composition of the formulations. The HPLC was calibrated using standards of RA, RB, RC, RD, RE, RF, RG, RM, and RN.

[0920] raw material

[0921] Reference standards of steviol glycosides (Reb A, Reb B, Reb C, Reb D, Reb E, Reb F, Reb G, Reb M, Reb N) were provided by Chromadex (LGC Germany). Solvents and reagents (HLC grade) were provided by VMR (Vienna) or Sigma-Aldrich (Vienna).

[0922] Davisil Grade 633 (high purity grade silica gel, pore size 200-425 mesh size) was supplied by Sigma-Aldrich (Vienna).

[0923] Sample preparation

[0924] 300 mg of the sample was dissolved in 20 ml of acetonitrile / H2O=9 / 1 (v / v).

[0925] HPLC method

[0926] The HPLC system consisted of an Agilent 1100 system (autosampler, ternary gradient pump, column oven, WD-UV / VIS detector, DAD-UV / VIS detector) connected in series with an Agilent mass spectrometer (ESI-MS quadrupole G1956A VL). For HPLC analysis, 150 mg of the corresponding sample was dissolved in acetonitrile (1 ml) and filled up to 10 ml with water.

[0927] The samples were separated at 0.8 ml / min in a Phenomenex Synergi Hydro-RP (150 x 3 mm) and then gradient eluted at 45°C through a Macherey-Nagel Nucleosil 100-7C18 (250 x 4.6 mm).

[0928] Mobile phase A consisted of 0.01 molar NH4-acetate buffer (native pH) and 0.1% acetic acid, 0.05% trimethylamine and 0.001% dichloromethane. Mobile phase B consisted of 0.01 molar NH4-acetate buffer (native pH), acetonitrile (1 / 9 v / v) and 0.1% acetic acid, 0.05% trimethylamine and 0.001% dichloromethane. The gradient started from 22% B and increased linearly to 45% B in 20 min and was retained under such conditions for another 15 minutes. The injection volume was set to 10 μl.

[0929] The detector settings were 210 nm (VWD), 205 and 254 nm (DAD collecting spectra between 200-600 nm) and ESI negative mode TIC m / z 300-1500, fragmentor voltage 200, gain 2 (MS, 300°C, nitrogen 12 l / min, nebulizer set at 50 psig, capillary voltage 4500 V).

[0930] Spectra were quantified using detection at 210 nm. Molecular weight and structural information of each peak was determined using MS-spectroscopy. Non-SG peaks were identified using detection at 254 nm.

[0931] Qualitative and quantitative

[0932] SGs were identified by comparison with retention times of authentic reference standards and / or evaluation of the resulting mass spectra including interpretation of fragmentation patterns and doubly charged ions due to the presence of dichloromethane.

[0933] Steviol glycosides were quantified by external standard method. In the absence of reference standards, Reb-A was quantified.

[0934] The maximum calibration range of the reference standard is in the range of 0.1-50 mg / 10 ml (dissolved in acetonitrile / H2O=9 / 1 (v / v)).

[0935] Tables 29-31 show the SG content in exemplary compositions of the present invention.

[0936] Table 29 Steviol glycosides (163.4 mg / 10 ml) of batch number 20180122-2-1

[0937] Batch No. 20180122-2-1: Commercially available from Sweet Green Fields. Prepared according to the method described in Example 11. It is a spray-dried powder of the supernatant of the crude extract.

[0938]

[0939]

[0940] Table 30 Steviol glycosides (172.1 mg / 10 ml) of batch number 20180156-2

[0941] Batch No. 20180156-2: Commercially available from Sweet Green Fields. Prepared according to the method described in Example 11. It is a spray-dried powder of the supernatant of the crude extract.

[0942]

[0943]

[0944]

[0945] Table 31 Steviol glycosides (168.9 mg / 10 ml) of batch number 20180143-1

[0946] Batch No. 20180143-1: Commercially available from Sweet Green Fields. Prepared according to the method described in Example 11. It is a spray-dried powder of the supernatant of the crude extract.

[0947]

[0948]

[0949] Example 15 SG composition of exemplary samples

[0950] In another separate analysis, multiple samples of additional exemplary liquid formulations were subjected to HPLC to determine the SG composition of the formulations. The HPLC was calibrated using standards of RA, RB, RC, RD, RE, RF, RG, RM, and RN.

[0951] raw material

[0952] Reference standards of steviol glycosides (Reb A, Reb B, Reb C, Reb D, Reb E, Reb F, Reb G, Reb M, Reb N) were provided by Chromadex (LGC Germany). Solvents and reagents (HLC grade) were provided by VMR (Vienna) or Sigma-Aldrich (Vienna).

[0953] Davisil Grade 633 (high purity grade silica gel, pore size 200-425 mesh size) was supplied by Sigma-Aldrich (Vienna).

[0954] Sample preparation

[0955] 300 mg of the sample was dissolved in 20 ml of acetonitrile / H2O=9 / 1 (v / v).

[0956] HPLC method

[0957] The HPLC system consisted of an Agilent 1100 system (autosampler, ternary gradient pump, column oven, WD-UV / VIS detector, DAD-UV / VIS detector) connected in series with an Agilent mass spectrometer (ESI-MS quadrupole G1956A VL). For HPLC analysis, 150 mg of the corresponding sample was dissolved in acetonitrile (1 ml) and filled up to 10 ml with water.

[0958] The samples were separated in a Phenomenex Synergi Hydro-RP (150 x 3 mm) at 0.8 ml / min and then gradient eluted through a Macherey-Nagel Nucleosil 100-7 C18 (250 x 4.6 mm) at 45°C.

[0959] Mobile phase A consisted of 0.01 molar NH4-acetate buffer (native pH) and 0.1% acetic acid, 0.05% trimethylamine and 0.001% dichloromethane. Mobile phase B consisted of 0.01 molar NH4-acetate buffer (native pH), acetonitrile (1 / 9 v / v) and 0.1% acetic acid, 0.05% trimethylamine and 0.001% dichloromethane. The gradient started from 22% B and increased linearly to 45% B in 20 min and was retained under such conditions for another 15 minutes. The injection volume was set to 10 μl.

[0960] The detector settings were 210 nm (VWD), 205 and 254 nm (DAD collecting spectra between 200-600 nm) and ESI negative mode TIC m / z 300-1500, fragmentor voltage 200, gain 2 (MS, 300°C, nitrogen 12 l / min, nebulizer set at 50 psig, capillary voltage 4500 V).

[0961] Spectra were quantified using detection at 210 nm. Molecular weight and structural information of each peak was determined using MS-spectroscopy. Non-SG peaks were identified using detection at 254 nm.

[0962] Qualitative and quantitative

[0963] SGs were identified by comparison with retention times of authentic reference standards and / or evaluation of the resulting mass spectra including interpretation of fragmentation patterns and doubly charged ions due to the presence of dichloromethane.

[0964] Steviol glycosides were quantified by external standard method. In the absence of reference standards, Reb-A was quantified.

[0965] The maximum calibration range of the reference standard is in the range of 0.1-50 mg / 10 ml (dissolved in acetonitrile / H2O=9 / 1 (v / v)).

[0966] Table 32 shows the SG content in exemplary compositions of the present invention.

[0967] Table 32 Steviol glycosides (179.7 mg / 10 ml) of sample 20170705

[0968] Sample 20170705: Commercially available from Sweet Green Fields. Prepared according to the method described in Example 11. Is a crude extract.

[0969]

[0970]

[0971] Example 16. SG concentrations to achieve sweetness of 3%, 5%, and 7% sucrose solutions

[0972] Solutions of different SG standards and SG compositions were prepared and compared to 3%, 5%, and 7% sucrose solutions. The goal was to find the amount that achieved the same maximum sweetness as the reference solution.

[0973] Material

[0974] Reference standards of sucrose at concentrations of 3%, 5%, and 7% were prepared in purified H 2 O. Dilutions of sample composition #3 (Table 16), sample composition #4 (Table 17), sample composition #11 (Table 24), and sample composition #12 (Table 25) were also prepared in purified H 2 O.

[0975] Sample testing

[0976] The sucrose equivalency (SE) of each was established by having a panel of trained tasters taste sample dilutions of the SG compositions and compare to 3%, 5% and 7% sucrose solutions to determine the concentration (in ppm) at which each was equivalent in sweetness to the sucrose concentration.

[0977] The results are shown in Table 33 for the sample compositions.

[0978] Table 33: Sucrose equivalent concentration of SG sample composition

[0979] SG Composition Sucrose solution SE[ppm] Sample Composition #3 3％ 160 Sample Composition #4 3％ 149 Sample composition #11 3％ 164 Sample Composition #12 3％ 159 Sample Composition #3 5％ 398 Sample Composition #4 5％ 392 Sample composition #11 5％ 404 Sample Composition #12 5％ 416 Sample Composition #3 7％ 651 Sample Composition #4 7％ 687 Sample composition #11 7％ 701 Sample Composition #12 7％ 692

[0980] Sweetness profiles were then generated for Sample Composition #3, Sample Composition #4, Sample Composition #11, and Sample Composition #12 at each SE concentration. A general example of a sweetness profile is given in Fig.19A Shown in. Fig.19B The sweetness profile of 5% sucrose is shown in .

[0981] Sample testing

[0982] Sample Composition #3, Sample Composition #4, Sample Composition #11 and Sample Composition #12 were tested at the concentrations shown in Table 33. The results are shown in Table 34 (3% SE), Table 35 (5% SE) and Table 36 (7% SE).

[0983] Table 34: Sweetness profile of sample compositions at 3% SE

[0984]

[0985]

[0986] Table 35: Sweetness profile of sample compositions at 5% SE

[0987]

[0988] Table 36: Sweetness profile of sample compositions at 7% SE

[0989]

[0990] The sweetness profiles of sample compositions 3, 4, 11 and 12 are graphically represented in Fig. 20A -D.

[0991] Example 17. Establishing the Charming Threshold and Detection Threshold of SG Compositions

[0992] Test solution

[0993] SG sample compositions #3 (Table 16), #4 (Table 17), #5 (Table 18), #6 (Table 19), #7 (Table 20), #8 (Table 21), #9 (Table 22), #10 (Table 23), #11 (Table 24), #12 (Table 25) and #13 (Table 26) were diluted separately to establish the attractiveness threshold (CT) and the detection threshold (DT). Equal amounts of the combined mixture of sample compositions #3-#10 (Pool 3-10) and equal amounts of the combined mixture of sample compositions #11-#13 (Pool 11-13) were also diluted to establish the CT and DT.

[0994] Serial dilutions of 0, 2.5, 5.0, 7.5, 10.0, 12.5, 15.0, 17.5 and 20.0 mg / L were prepared. Concentrations were selected after a brief, open tasting of 20 mg / L (5 panelists), where all sample compositions were considered "sweet".

[0995] For the triangle test, the following samples were selected: CT concentrations of pools 3-10 and 11-13; DT concentrations of pools 3-10 and 11-13; sucrose CT concentration (3 g / L); and sucrose solution (15 g / L) was evaluated as a low intensity, but noticeably sweet concentration.

[0996] Determination of threshold

[0997] CT (defined as the concentration at which a difference from pure water is observed but no taste description is given) and DT (defined as the concentration at which a difference from pure water is observed and a correct taste description is given) were established. The diluted solutions were presented to 10 panelists in ascending order of concentration. The panelists indicated their perception in a table, as shown in Table 43, with "0" for no taste, "?" for unclear taste perception, "x" for sweetness perception, or "xx"-"xxxxx" for increased sweetness perception.

[0998] Table 37: Taste perception scoring table

[0999]

[1000] The corresponding individual thresholds are then calculated from the individual panelist results according to the following formula:

[1001] Formula 1a:

[1002] and

[1003] Formula 1b:

[1004] C CT is the charm threshold concentration, C CT-1 The concentration is lower than this concentration, C DT is the detection threshold concentration, C DT-1 concentration is lower than this concentration.

[1005] The final group value is then calculated using the following formula:

[1006] Formula 2a:

[1007] and

[1008] Formula 2b:

[1009] Triangle test

[1010] According to Table 38, 24 testers were selected to establish a scenario with a probability of 95% (100-β) in which 50% of the expert panel members (pd) were able to identify the existing differences, with a significance level of α=0.05.

[1011] Table 38: Minimum number of panelists for triangulation testing

[1012]

[1013] Panelists randomly assigned the following six sequences: ABB, BAA, AAB, ABA, BBA, and BAB to two samples, A and B. The samples were labeled with random 3-digit numbers.

[1014] After the test was performed, the number of correct answers (i.e., correctly identifying the difference between the samples) was compared to Table 39 (the minimum requirement, correct answers, to establish a difference at a given significance level).

[1015] Table 39: Minimum number of correct answers for triangular tests to establish differences

[1016]

[1017] The results of the CT concentration and DT concentration determinations are shown in Tables 40 to 42. The bold numbers indicate the majority decision of the panelists; the first evaluation was "different from water, undefined taste" and the second evaluation was "different from water, sweet taste".

[1018] Table 40: Threshold concentrations from test results

[1019]

[1020]

[1021] Table 41: Calculated group thresholds (according to formulas 1a and 1b)

[1022] [...

Claims

1. A composition comprising two groups of SG, wherein the first group of SG comprises one or more SGs, wherein the one or more SGs have a parent structure of formula II or formula III; wherein R1 and R2 are substituents selected from glucosyl (G), rhamnosyl (R), xylosyl (X), deoxyglucosyl (dG), fructosyl (F), arabinosyl (A), galactosyl (Ga) or any combination of the above substituents, and wherein the number of glucosyl groups is equal to or greater than 4; the second group of SG comprises one or more SGs selected from RA, RB, stevioside (ST), RC, RD, RM or a combination thereof; wherein the content of the first group of SG in the total SG is 1-30wt%; The parent structure of Formula II is: ； The parent structure of Formula III is: ； The one or more SGs in the first group of SGs are selected from related SG#2, related SG#5, RU2, RT, RW, RW2, RW3, RU, SG-12, RH, RJ, RK, RK2, SG-Unk4, SG-Unk5, RD, RI, RL, RI3, SG-Unk6, RQ, RI2, RQ2, RQ3, RT1, related SG#4, RV2, RV, RY, RN, RM, 15α-OH RM, RO and RO2; The composition at least comprises RD, RM, RA and stevioside, wherein: The amount of RD is 0.1-25wt%, the amount of RM is 0.1-25wt%; ST is 14-40wt% of the total SG in the composition; the amount of RA is 10-80wt%; The total SG contains 3-30wt% of various SGs with a molecular weight equal to or greater than 1097 Daltons and combinations thereof.

2. The composition according to claim 1, wherein The weight ratio of the first group SG to the second group SG is 1:99; 2:98; 3:97; 4:96; 5:95; 6:94; 7:93; 8:94; 9:91; 10:90; 11:89; 12:88; 13:87; 14:86; 15:85; 16:84; 17:83; 18:82; 19:81; 20:80; 21:79; 22:78; 23:77; 2 ... :76; 25:75; 26:74; 27:73; 28:72; 29:71; 30:70; 31:69; 32:68; 33:67; 34:66; 35:65; 36:64; 7:63; 38:62; 39:61; 40:60; 41:59; 42:58; 43:57; 44:56; 45:55; 46:54; 47:53; 48:52; 4 9:51; 50:50; 51:49; 52:48; 53:47; 54:45; 55:45; 56:44; 57:43; 58:42; 59:41; 60:40; 61:39; 62:38; 63:37; 64:36; 65:35; 66:37; 67:33; 68:32; 69:31; 70:30; 71:29; 72:28; 73:27 ; 74:26; 75:25; 76:24; 77:23; 78:22; 79:21; 80:20; 81:19; 82:18; 83:17; 84:16; 85:15; 86:14; 87:13; 88:12; 89:11; 90:10; 91:9; 92:8; 93:7; 94:6; 95:5; 96:4; 97:3; 98:2 or 99:

1.

3. The composition according to claim 1, wherein The number of rhamnosyl groups is equal to or greater than 1; and / or, the number of xylosyl groups is equal to or greater than 1; and / or, the number of deoxyglucosyl groups is equal to or greater than 1; and / or, the number of fructosyl groups is equal to or greater than 1; and / or, the number of arabinosyl groups is equal to or greater than 1; and / or, the number of galactosyl groups is equal to or greater than 1.

4. The composition according to claim 2, wherein The number of rhamnosyl groups is equal to or greater than 1; and / or, the number of xylosyl groups is equal to or greater than 1; and / or, the number of deoxyglucosyl groups is equal to or greater than 1; and / or, the number of fructosyl groups is equal to or greater than 1; and / or, the number of arabinosyl groups is equal to or greater than 1; and / or, the number of galactosyl groups is equal to or greater than 1.

5. The composition according to claim 1, wherein The composition comprises RB in an amount of 0-30 wt %; and / or the composition comprises RC in an amount of 0-30 wt %.

6. The composition according to claim 2, wherein The composition comprises RB in an amount of 0-30 wt %; and / or the composition comprises RC in an amount of 0-30 wt %.

7. The composition according to claim 3, wherein The composition comprises RB in an amount of 0-30 wt %; and / or the composition comprises RC in an amount of 0-30 wt %.

8. The composition according to claim 1, wherein The composition comprises RA in an amount of 20-70 wt %; and / or, the composition comprises RB in an amount of 0.1-25 wt %; and / or, the composition comprises RC in an amount of 0.1-25 wt %.

9. The composition according to claim 1, wherein The composition comprises 3-30 wt % of one or more SGs having a molecular weight equal to or greater than 1111 Daltons and combinations thereof.

10. The composition according to claim 2, wherein The composition comprises 3-30 wt % of one or more SGs having a molecular weight equal to or greater than 1111 Daltons and combinations thereof.

11. The composition according to claim 5, wherein The composition comprises 3-30 wt % of one or more SGs having a molecular weight equal to or greater than 1111 Daltons and combinations thereof.

12. The composition according to claim 1, wherein The composition comprises 3-20 wt % of one or more SGs having a molecular weight equal to or greater than 1111 Daltons and combinations thereof.

13. The composition according to claim 1, wherein The composition comprises 3-30 wt % of one or more SGs having a molecular weight equal to or greater than 1127 Daltons and combinations thereof.

14. The composition according to claim 2, wherein The composition comprises 3-30 wt % of one or more SGs having a molecular weight equal to or greater than 1127 Daltons and combinations thereof.

15. The composition according to claim 5, wherein The composition comprises 3-30 wt % of one or more SGs having a molecular weight equal to or greater than 1127 Daltons and combinations thereof.

16. The composition according to claim 9, wherein The composition comprises 3-30 wt % of one or more SGs having a molecular weight equal to or greater than 1127 Daltons and combinations thereof.

17. The composition according to claim 1, wherein The composition comprises 3-20 wt % of one or more SGs having a molecular weight equal to or greater than 1127 Daltons and combinations thereof.

18. The composition according to claim 1, wherein The composition comprises 3-30 wt % of one or more SGs having a molecular weight equal to or greater than 1259 Daltons and combinations thereof.

19. The composition according to claim 2, wherein The composition comprises 3-30 wt % of one or more SGs having a molecular weight equal to or greater than 1259 Daltons and combinations thereof.

20. The composition according to claim 5, wherein The composition comprises 3-30 wt % of one or more SGs having a molecular weight equal to or greater than 1259 Daltons and combinations thereof.

21. The composition according to claim 9, wherein The composition comprises 3-30 wt % of one or more SGs having a molecular weight equal to or greater than 1259 Daltons and combinations thereof.

22. The composition according to claim 13, wherein The composition comprises 3-30 wt % of one or more SGs having a molecular weight equal to or greater than 1259 Daltons and combinations thereof.

23. The composition according to claim 1, wherein The composition comprises 3-20 wt% of one or more SGs having a molecular weight equal to or greater than 1259 Daltons and combinations thereof.

24. The composition according to claim 1, wherein The composition comprises 3-30 wt % of one or more SGs having a molecular weight equal to or greater than 1273 Daltons and combinations thereof.

25. The composition according to claim 2, wherein The composition comprises 3-30 wt % of one or more SGs having a molecular weight equal to or greater than 1273 Daltons and combinations thereof.

26. The composition according to claim 5, wherein The composition comprises 3-30 wt % of one or more SGs having a molecular weight equal to or greater than 1273 Daltons and combinations thereof.

27. The composition according to claim 9, wherein The composition comprises 3-30 wt % of one or more SGs having a molecular weight equal to or greater than 1273 Daltons and combinations thereof.

28. The composition according to claim 13, wherein The composition comprises 3-30 wt % of one or more SGs having a molecular weight equal to or greater than 1273 Daltons and combinations thereof.

29. The composition according to claim 18, wherein The composition comprises 3-30 wt % of one or more SGs having a molecular weight equal to or greater than 1273 Daltons and combinations thereof.

30. The composition according to claim 1, wherein The composition comprises 3-20 wt % of one or more SGs having a molecular weight equal to or greater than 1273 Daltons and combinations thereof.

31. The composition according to claim 1, wherein The composition comprises 3-30 wt % of one or more SGs having a molecular weight equal to or greater than 1289 Daltons and combinations thereof.

32. The composition according to claim 2, wherein The composition comprises 3-30 wt % of one or more SGs having a molecular weight equal to or greater than 1289 Daltons and combinations thereof.

33. The composition according to claim 5, wherein The composition comprises 3-30 wt % of one or more SGs having a molecular weight equal to or greater than 1289 Daltons and combinations thereof.

34. The composition according to claim 9, wherein The composition comprises 3-30 wt % of one or more SGs having a molecular weight equal to or greater than 1289 Daltons and combinations thereof.

35. The composition according to claim 13, wherein The composition comprises 3-30 wt % of one or more SGs having a molecular weight equal to or greater than 1289 Daltons and combinations thereof.

36. The composition according to claim 18, wherein The composition comprises 3-30 wt % of one or more SGs having a molecular weight equal to or greater than 1289 Daltons and combinations thereof.

37. The composition according to claim 24, wherein The composition comprises 3-30 wt % of one or more SGs having a molecular weight equal to or greater than 1289 Daltons and combinations thereof.

38. The composition according to claim 1, wherein The composition comprises 3-20 wt % of one or more SGs having a molecular weight equal to or greater than 1289 Daltons and combinations thereof.

39. A composition according to any one of claims 1 to 38, wherein The composition comprises 3-30 wt % of one or more SGs having a molecular weight equal to or greater than 1305 Daltons and combinations thereof.

40. A composition according to any one of claims 1 to 38, wherein The composition comprises 3-20 wt % of one or more SGs having a molecular weight equal to or greater than 1305 Daltons and combinations thereof.

41. A composition according to any one of claims 1 to 38, wherein The composition comprises 3-30 wt % of one or more SGs having a molecular weight equal to or greater than 1435 Daltons and combinations thereof.

42. The composition according to claim 39, wherein The composition comprises 3-30 wt % of one or more SGs having a molecular weight equal to or greater than 1435 Daltons and combinations thereof.

43. A composition according to any one of claims 1 to 38, wherein The composition comprises 3-20 wt % of one or more SGs having a molecular weight equal to or greater than 1435 Daltons and combinations thereof.

44. A composition according to any one of claims 1 to 38, wherein One or more SG in the first group of SGs contains: relevant SG#2 accounting for 0-30wt% of the total SG in the composition; and / or, relevant SG#5 accounting for 0-30wt% of the total SG in the composition; and / or, RU2 accounting for 0-30wt% of the total SG in the composition; and / or, RT accounting for 0-30wt% of the total SG in the composition; and / or, RW accounting for 0-30wt% of the total SG in the composition; and / or, RW2 accounting for 0-30wt% of the total SG in the composition; and / or, wt% of RW3; and / or, RU accounting for 0-30wt% of the total SG in the composition; and / or, SG-12 accounting for 0-30wt% of the total SG in the composition; and / or, RH accounting for 0-30wt% of the total SG in the composition; and / or, RJ accounting for 0-30wt% of the total SG in the composition; and / or, RK accounting for 0-30wt% of the total SG in the composition; and / or, RK2 accounting for 0-30wt% of the total SG in the composition; and / or, SG-Unk4 accounting for 0-30wt% of the total SG in the composition; and / or, SG-Unk5 accounting for 0-30wt% of the total SG in the composition; and / or, RI accounting for 0-30wt% of the total SG in the composition; and / or, RL accounting for 0-30wt% of the total SG in the composition; and / or, RI3 accounting for 0-30wt% of the total SG in the composition; and / or, SG-Unk6 accounting for 0-30wt% of the total SG in the composition; and / or, RQ accounting for 0-30wt% of the total SG in the composition; and / or, RQ2 accounting for 0-30wt% of the total SG in the composition ; and / or, RQ3 accounting for 0-30wt% of the total SG in the composition; and / or, RT1 accounting for 0-30wt% of the total SG in the composition; and / or, related SG#4 accounting for 0-30wt% of the total SG in the composition; and / or, RV accounting for 0-30wt% of the total SG in the composition; and / or, RV2 accounting for 0-30wt% of the total SG in the composition; and / or, RY accounting for 0-30wt% of the total SG in the composition; and / or, 15α-OH RM accounting for 0-30wt% of the total SG in the composition; and / or, RO2 accounting for 0-30wt% of the total SG in the composition.

45. The composition according to claim 39, wherein One or more SG in the first group of SGs contains: relevant SG#2 accounting for 0-30wt% of the total SG in the composition; and / or, relevant SG#5 accounting for 0-30wt% of the total SG in the composition; and / or, RU2 accounting for 0-30wt% of the total SG in the composition; and / or, RT accounting for 0-30wt% of the total SG in the composition; and / or, RW accounting for 0-30wt% of the total SG in the composition; and / or, RW2 accounting for 0-30wt% of the total SG in the composition; and / or, wt% of RW3; and / or, RU accounting for 0-30wt% of the total SG in the composition; and / or, SG-12 accounting for 0-30wt% of the total SG in the composition; and / or, RH accounting for 0-30wt% of the total SG in the composition; and / or, RJ accounting for 0-30wt% of the total SG in the composition; and / or, RK accounting for 0-30wt% of the total SG in the composition; and / or, RK2 accounting for 0-30wt% of the total SG in the composition; and / or, SG-Unk4 accounting for 0-30wt% of the total SG in the composition; and / or, SG-Unk5 accounting for 0-30wt% of the total SG in the composition; and / or, RI accounting for 0-30wt% of the total SG in the composition; and / or, RL accounting for 0-30wt% of the total SG in the composition; and / or, RI3 accounting for 0-30wt% of the total SG in the composition; and / or, SG-Unk6 accounting for 0-30wt% of the total SG in the composition; and / or, RQ accounting for 0-30wt% of the total SG in the composition; and / or, RQ2 accounting for 0-30wt% of the total SG in the composition ; and / or, RQ3 accounting for 0-30wt% of the total SG in the composition; and / or, RT1 accounting for 0-30wt% of the total SG in the composition; and / or, related SG#4 accounting for 0-30wt% of the total SG in the composition; and / or, RV accounting for 0-30wt% of the total SG in the composition; and / or, RV2 accounting for 0-30wt% of the total SG in the composition; and / or, RY accounting for 0-30wt% of the total SG in the composition; and / or, 15α-OH RM accounting for 0-30wt% of the total SG in the composition; and / or, RO2 accounting for 0-30wt% of the total SG in the composition.

46. ​​The composition according to claim 41, wherein One or more SG in the first group of SGs contains: relevant SG#2 accounting for 0-30wt% of the total SG in the composition; and / or, relevant SG#5 accounting for 0-30wt% of the total SG in the composition; and / or, RU2 accounting for 0-30wt% of the total SG in the composition; and / or, RT accounting for 0-30wt% of the total SG in the composition; and / or, RW accounting for 0-30wt% of the total SG in the composition; and / or, RW2 accounting for 0-30wt% of the total SG in the composition; and / or, wt% of RW3; and / or, RU accounting for 0-30wt% of the total SG in the composition; and / or, SG-12 accounting for 0-30wt% of the total SG in the composition; and / or, RH accounting for 0-30wt% of the total SG in the composition; and / or, RJ accounting for 0-30wt% of the total SG in the composition; and / or, RK accounting for 0-30wt% of the total SG in the composition; and / or, RK2 accounting for 0-30wt% of the total SG in the composition; and / or, SG-Unk4 accounting for 0-30wt% of the total SG in the composition; and / or, SG-Unk5 accounting for 0-30wt% of the total SG in the composition; and / or, RI accounting for 0-30wt% of the total SG in the composition; and / or, RL accounting for 0-30wt% of the total SG in the composition; and / or, RI3 accounting for 0-30wt% of the total SG in the composition; and / or, SG-Unk6 accounting for 0-30wt% of the total SG in the composition; and / or, RQ accounting for 0-30wt% of the total SG in the composition; and / or, RQ2 accounting for 0-30wt% of the total SG in the composition ; and / or, RQ3 accounting for 0-30wt% of the total SG in the composition; and / or, RT1 accounting for 0-30wt% of the total SG in the composition; and / or, related SG#4 accounting for 0-30wt% of the total SG in the composition; and / or, RV accounting for 0-30wt% of the total SG in the composition; and / or, RV2 accounting for 0-30wt% of the total SG in the composition; and / or, RY accounting for 0-30wt% of the total SG in the composition; and / or, 15α-OH RM accounting for 0-30wt% of the total SG in the composition; and / or, RO2 accounting for 0-30wt% of the total SG in the composition.

47. A composition according to any one of claims 1 to 38, wherein One or more SGs in the first group of SGs contain: relevant SG#2 accounting for 0.1-25wt% of the total SG in the composition; and / or, relevant SG#5 accounting for 0.1-25wt% of the total SG in the composition; and / or, RU2 accounting for 0.1-25wt% of the total SG in the composition; and / or, RT accounting for 0.1-25wt% of the total SG in the composition; and / or, RW accounting for 0.1-25wt% of the total SG in the composition; and / or, RW2 accounting for 0.1-25wt% of the total SG in the composition; and / or, RW3 accounting for 0.1-25wt% of the total SG in the composition; and / or, RU accounting for 0.1-25wt% of the total SG in the composition; and / or, SG-12 accounting for 0.1-25wt% of the total SG in the composition; and / or, RH accounting for 0.1-25wt% of the total SG in the composition; and / or , RJ accounting for 0.1-25wt% of the total SG in the composition; and / or, RK accounting for 0.1-25wt% of the total SG in the composition; and / or, RK2 accounting for 0.1-25wt% of the total SG in the composition; and / or, SG-Unk4 accounting for 0.1-25wt% of the total SG in the composition; and / or, SG-Unk5 accounting for 0.1-25wt% of the total SG in the composition; and / or, RI accounting for 0.1-25wt% of the total SG in the composition; and / or, RL accounting for 0.1-25wt% of the total SG in the composition; and / or, RI3 accounting for 0.1-25wt% of the total SG in the composition; and / or, SG-Unk6 accounting for 0.1-25wt% of the total SG in the composition; and / or, RQ accounting for 0.1-25wt% of the total SG in the composition; and / or, RQ2 accounting for 0.1-25wt% of the total SG in the composition; and / or, RQ3 accounting for 0.1-25wt% of the total SG in the composition; and / or, RT1 accounting for 0.1-25wt% of the total SG in the composition; and / or, related SG#4 accounting for 0.1-25wt% of the total SG in the composition; and / or, RV accounting for 0.1-25wt% of the total SG in the composition; and / or, RV2 accounting for 0.1-25wt% of the total SG in the composition; and / or, RY accounting for 0.1-25wt% of the total SG in the composition; and / or, 15α-OH RM accounting for 0.1-25wt% of the total SG in the composition; and / or, RO2 accounting for 0.1-25wt% of the total SG in the composition.

48. A composition according to any one of claims 1 to 38, wherein The composition has an improved taste profile, including aftertaste, bitterness and / or lingering, compared to a composition not comprising the composition of any one of claims 1-38.

49. The composition according to claim 39, wherein The composition has an improved taste profile, including aftertaste, bitterness and / or lingering, compared to a composition not comprising the composition of claim 39.

50. The composition according to claim 41, wherein The composition has an improved taste profile, including aftertaste, bitterness and / or lingering, compared to a composition not comprising the composition of claim 41.

51. The composition according to claim 44, wherein The composition has an improved taste profile, including aftertaste, bitterness and / or lingering, compared to a composition not comprising the composition of claim 44.

52. A composition according to any one of claims 1 to 38, wherein The composition has increased solubility in aqueous solutions compared to a composition not comprising the composition of any one of claims 1-38.

53. The composition according to claim 39, wherein The composition has increased solubility in aqueous solutions compared to compositions not comprising the composition of claim 39.

54. The composition according to claim 41, wherein The composition has increased solubility in aqueous solutions compared to compositions not comprising the composition of claim 41.

55. The composition of claim 44, wherein The composition has increased solubility in aqueous solutions compared to compositions not comprising the composition of claim 44.

56. The composition according to claim 48, wherein The composition has increased solubility in aqueous solutions compared to compositions not comprising the composition of claim 48.

57. A composition according to any one of claims 1 to 38, wherein further comprising one or more non-SG sweeteners; and / or, further comprising one or more salts; and / or, the composition comprises trace amounts of non-SG off-flavor components.

58. The composition according to claim 39, wherein further comprising one or more non-SG sweeteners; and / or, further comprising one or more salts; and / or, the composition comprises trace amounts of non-SG off-flavor components.

59. The composition according to claim 41, wherein further comprising one or more non-SG sweeteners; and / or, further comprising one or more salts; and / or, the composition comprises trace amounts of non-SG off-flavor components.

60. The composition of claim 44, wherein further comprising one or more non-SG sweeteners; and / or, further comprising one or more salts; and / or, the composition comprises trace amounts of non-SG off-flavor components.

61. The composition according to claim 48, wherein further comprising one or more non-SG sweeteners; and / or, further comprising one or more salts; and / or, the composition comprises trace amounts of non-SG off-flavor components.

62. The composition according to claim 52, wherein further comprising one or more non-SG sweeteners; and / or, further comprising one or more salts; and / or, the composition comprises trace amounts of non-SG off-flavor components.

63. A composition according to any one of claims 1-38, wherein The composition is a sweetener; and / or, the composition is a flavoring agent.

64. The composition according to claim 39, wherein The composition is a sweetener; and / or, the composition is a flavoring agent.

65. The composition according to claim 41, wherein The composition is a sweetener; and / or, the composition is a flavoring agent.

66. The composition of claim 44, wherein The composition is a sweetener; and / or, the composition is a flavoring agent.

67. The composition according to claim 48, wherein The composition is a sweetener; and / or, the composition is a flavoring agent.

68. The composition of claim 52, wherein The composition is a sweetener; and / or, the composition is a flavoring agent.

69. The composition according to claim 57, wherein The composition is a sweetener; and / or, the composition is a flavoring agent.

70. A method for preparing the composition of any one of claims 1 to 69, comprising the steps of: dissolving an extract of stevia plant leaves in a first ethanol-water solution to form a mixture; The mixture is heated until the mixture becomes a solution; The solution was cooled to ambient temperature; separating the supernatant and the precipitate of the solution; drying the supernatant to form a powder; dissolving the powder with water to form a second solution; treating the second solution with a macroporous resin to obtain a material; The material was desorbed with a second aqueous ethanol solution.

71. The preparation method according to claim 70, wherein The concentration of the second ethanol aqueous solution is greater than 0 and less than 50 wt %.

72. The preparation method according to claim 70, wherein The concentration of the second ethanol aqueous solution is 20-50 wt %.

73. The preparation method according to claim 70, wherein The concentration of the second ethanol aqueous solution is 25-35 wt %.

74. The preparation method according to claim 70, wherein The concentration of the second ethanol aqueous solution is 50-100 wt %.

75. The preparation method according to claim 70, wherein The concentration of the second ethanol aqueous solution is 60-80 wt %.

76. The preparation method according to claim 70, wherein The concentration of the second ethanol aqueous solution is 65-75 wt %.

77. A composition, characterized in that The composition is prepared by the method for preparing the composition according to any one of claims 70-76.

78. Use of the composition of any one of claims 1-69 or the composition of claim 77 in an orally consumable product.

79. The use according to claim 78, wherein: The composition is used in candies, condiments, chewing compositions, cereal compositions, baked foods, dairy products and sweetener compositions thereof, beverages and drinks, pharmaceutical compositions or smoked compositions.

80. Use of the composition of any one of claims 1-69 or the composition of claim 77 in an oral hygiene composition.

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