A cleaning and bacteriostatic liquid and its preparation method

Abstract

The present invention discloses a cleaning and bacteriostatic liquid and a preparation method thereof, which include lactic acid, ammonium lauryl polyoxyethylene ether sulfate, fatty alcohol polyoxyethylene ether glucoside, coconut oil diethanolamide, coconut oil amide propyl amine oxide, a moisturizing agent and purified water. The cleaning and bacteriostatic liquid of the present invention is a viscous liquid in terms of product type, with lactic acid as the main bacteriostatic component, and ammonium lauryl polyoxyethylene ether sulfate, fatty alcohol polyoxyethylene ether glucoside, coconut oil diethanolamide, coconut oil amide propyl amine oxide as surfactants, which is applicable to the cleaning and bacteriostasis of human skin, and has the advantages of being pollution-free, non-irritating, having delicate foam and being easy to rinse. The preparation method of the present invention is simple and feasible. During production, the surfactants crosslink with each other to form a viscous liquid, without the need to add a thickening agent, is easy to produce, and the product is stable, which is suitable for large-scale production in factories.

Description

Technical Field

[0001] The present invention belongs to the technical field of disinfection products, relates to a cleaning solution, and specifically relates to a female cleaning and bacteriostatic solution and a preparation method thereof. Background Art

[0002] Lactic acid, also known as 2-hydroxypropionic acid, is an important organic acid. It can be used as a raw material, additive, preservative, disinfectant, regulator, etc., and is widely used in brewing, food, cosmetics, medicine, textile, environmental protection and other fields. At present, lactic acid is mainly prepared by fermentation. Approximately 90% of commercially sold lactic acid is produced by microbial fermentation and is easily biodegradable in the environment. Research shows that lactic acid has a certain inhibitory and killing effect on common pathogenic bacteria in hospitals (Escherichia coli, Staphylococcus aureus, Candida albicans, Pseudomonas aeruginosa). Its principle of action is mainly to cause the death of pathogenic bacteria by prolonging the generation time of pathogenic bacteria and destroying the normal cell membrane potential of metabolism. It is commonly used for fumigation disinfection in hospital operating rooms and is a pollution-free bactericidal raw material.

[0003] Gynecological diseases are common diseases among women, affecting the health and safety of the human body and bringing inconvenience to normal work. The vaginal pH value is one of the important indicators for hospital examination of female gynecological diseases. The normal flora in the vagina is distributed on the side wall of the vagina. The most important resident bacteria are Lactobacillus that can produce hydrogen peroxide. It degrades glycogen to produce lactic acid, keeping the vagina at a certain acidity, inhibiting the growth of anaerobic bacteria, and maintaining the balance of the vaginal flora. Relevant research shows that for reproductive-age women with a normal menstrual cycle, under the condition of no vaginal infection, the vaginal pH value is between 3.5 and 4.5. When pathogenic bacteria invade, they will squeeze the living space of Lactobacillus, reduce Lactobacillus or glycogen, resulting in insufficient lactic acid secretion and thus an increase in the vaginal pH value.

[0004] At present, common female bacteriostatic cleaning agents on the market are often mainly composed of traditional Chinese medicine extracts. The main components of the products often consist of more than 4 different traditional Chinese medicine components. For example, the main components of the bacteriostatic liquid with hundred herbs disclosed in the patent publication number CN102614440A are extracted from 38 traditional Chinese medicine extracts; there are too many types of drugs, the components are complex, the effective components are not clear, and it is easy to cause certain irritation to the vaginal mucosa.

[0005] The patent publication number CN101396507A discloses a traditional Chinese medicine bacteriostatic liquid and its preparation method and application. It is also prepared by multiple ethanol extractions from 20 traditional Chinese medicines. The final alcohol concentration of this product is 35-45%. This concentration of ethanol itself has a certain bacteriostatic effect. It is impossible to determine whether the bacteriostatic effect of this product is due to ethanol or traditional Chinese medicine extracts, and at the same time, no relevant bacteriostatic experiments are done, so it is impossible to determine the bacteriostatic effect of this antibacterial female bacteriostatic cleaning agent in actual use. Summary of the Invention

[0006] To solve the above problems, the object of the present invention is to provide a product with both cleaning and antibacterial functions, and a preparation method of a disinfectant that is stable, has a good antibacterial effect, is easy to rinse, is safe and pollution-free, and is suitable for large-scale production in factories.

[0007] To achieve the above object, the present invention adopts the following technical solutions:

[0008] A cleaning and antibacterial liquid, the cleaning and antibacterial liquid includes: lactic acid, ammonium lauryl ether sulfate, alkyl polyglucoside, coconut oil diethanolamide, cocamidopropylamine oxide, a humectant, and purified water.

[0009] As a preferred embodiment of the present invention, by weight, the cleaning and antibacterial liquid includes 0.1 - 3.0 parts of lactic acid, 1.0 - 8.0 parts of ammonium lauryl ether sulfate, 1.0 - 7.0 parts of alkyl polyglucoside, 0.5 - 8.0 parts of coconut oil diethanolamide, 0.1 - 0.8 parts of cocamidopropylamine oxide, 0.1 - 1.0 part of a humectant, and 80.0 - 98 parts of purified water.

[0010] As a preferred embodiment of the present invention, by weight, the cleaning and antibacterial liquid includes 0.3 - 1.5 parts of lactic acid, 2.0 - 6.0 parts of ammonium lauryl ether sulfate, 2.0 - 5.0 parts of alkyl polyglucoside, 1.0 - 6.0 parts of coconut oil diethanolamide, 0.2 - 0.6 parts of cocamidopropylamine oxide, 0.1 - 0.8 part of a humectant, and 84.0 - 95 parts of purified water.

[0011] As a preferred embodiment of the present invention, by weight, the cleaning and antibacterial liquid includes 0.3 - 1.0 parts of lactic acid, 2.0 - 5.0 parts of ammonium lauryl ether sulfate, 2.0 - 4.0 parts of alkyl polyglucoside, 2.0 - 5.0 parts of coconut oil diethanolamide, 0.2 - 0.5 parts of cocamidopropylamine oxide, 0.1 - 0.5 part of a humectant, and 84.0 - 93.4 parts of purified water.

[0012] As a preferred embodiment of the present invention, the humectant is one or several mixtures of glycerol, propylene glycol, and polyethylene glycol.

[0013] The present invention also provides a preparation method of the above cleaning and antibacterial liquid, including the following steps:

[0014] 1) Add purified water to a container, and add ammonium lauryl ether sulfate, alkyl polyglucoside, and coconut oil diethanolamide, and stir until completely dissolved;

[0015] 2) While stirring, add the humectant to the system of step 1) and stir until evenly dissolved;

[0016] 3) Add lactic acid to the system in step 2) under stirring, and stir until dissolved.

[0017] 4) Adjust the pH.

[0018] 5) Add coconut amide propyl amine oxide to the system in step 4) under stirring, and stir until dissolved to obtain a cleaning and bacteriostatic liquid.

[0019] As a preferred embodiment of the present invention, in step 4), the pH is adjusted to 4.5 - 7.

[0020] As a preferred embodiment of the present invention, in steps 1) - 5), the stirring speed is 200 - 400 revolutions per minute.

[0021] Compared with the prior art, the present invention has the following beneficial effects:

[0022] (1) The cleaning and bacteriostatic liquid of the present invention has a strong bacteriostatic effect. The bacteriostatic rate against common hospital infection bacteria (Candida albicans, Staphylococcus aureus, Escherichia coli) is ≥ 99.9% after 2 minutes of action.

[0023] (2) The cleaning and bacteriostatic liquid of the present invention has fine foam and good cleaning effect.

[0024] (3) The cleaning and bacteriostatic liquid of the present invention has a mild formula, no irritation, good stability, no pollution to the environment, is safe and environmentally friendly, and is suitable for industrial production.

[0025] (4) The present invention uses lactic acid as the main bacteriostatic component, and the weak acidic formula is more suitable for female use. Detailed implementation manners

[0026] In order to make the technical means, creative features, achieved purposes and effects of the present invention easy to understand, the present invention will be further described below in conjunction with specific embodiments. However, the following embodiments are only the preferred embodiments of the present invention, not all of them. Based on the embodiments in the implementation manners, other embodiments obtained by those skilled in the art without creative labor all belong to the protection scope of the present invention. The experimental methods in the following embodiments are all conventional methods unless otherwise specified. The materials, reagents, etc. used in the following embodiments can all be obtained from commercial channels unless otherwise specified.

[0027] Example 1:

[0028] This example provides a cleaning and bacteriostatic liquid, and the raw materials by mass percentage include: 0.5 g of lactic acid, 2.5 g of ammonium lauryl ether sulfate, 3.0 g of fatty alcohol polyoxyethylene ether glucoside, 2.0 g of coconut oil diethanolamide, 0.2 g of coconut amide propyl amine oxide, 0.2 g of moisturizer, and 91.6 g of purified water.

[0029] The production method of the cleaning and bacteriostatic liquid is as follows:

[0030] (1) Add 91.6 g of purified water, 2.5 g of ammonium lauryl ether sulfate, 3.0 g of fatty alcohol polyoxyethylene ether glucoside, and 2.0 g of coconut oil diethanolamide to a container, and stir at a low speed until completely dissolved.

[0031] (2) While stirring, add 0.2 g of humectant and stir until evenly dissolved.

[0032] (3) Add 0.5 g of lactic acid under stirring and stir until dissolved.

[0033] (4) Add 0.2 g of coconut amide propylamine oxide under stirring and stir until dissolved.

[0034] Example 2:

[0035] This example provides a cleaning and bacteriostatic liquid. The raw materials by mass percentage include: 0.6 g of lactic acid, 3.0 g of ammonium lauryl ether sulfate, 2.0 g of fatty alcohol polyoxyethylene ether glucoside, 2.0 g of coconut oil diethanolamide, 0.3 g of coconut amide propylamine oxide, 0.3 g of humectant, and 91.8 g of purified water.

[0036] The production method of the cleaning and bacteriostatic liquid is as follows:

[0037] (1) Add 91.8 g of purified water, 3.0 g of ammonium lauryl ether sulfate, 2.0 g of fatty alcohol polyoxyethylene ether glucoside, and 2.0 g of coconut oil diethanolamide to a container, and stir at a low speed until completely dissolved.

[0038] (2) While stirring, add 0.3 g of humectant and stir until evenly dissolved.

[0039] (3) Add 0.6 g of lactic acid under stirring and stir until dissolved.

[0040] (4) Add 0.3 g of coconut amide propylamine oxide under stirring and stir until dissolved.

[0041] Example 3:

[0042] This example provides a cleaning and bacteriostatic liquid. The raw materials by mass percentage include: 0.7 g of lactic acid, 3.0 g of ammonium lauryl ether sulfate, 3.0 g of fatty alcohol polyoxyethylene ether glucoside, 1.5 g of coconut oil diethanolamide, 0.3 g of coconut amide propylamine oxide, 0.2 g of humectant, and 91.3 g of purified water.

[0043] The production method of the cleaning and bacteriostatic liquid is as follows:

[0044] (1) Add 91.3 g of purified water to a container, then add 3.0 g of ammonium lauryl ether sulfate, 3.0 g of fatty alcohol polyoxyethylene ether glucoside, and 1.5 g of coconut oil diethanol amide, and stir at low speed until completely dissolved.

[0045] (2) While stirring, add 0.2 g of humectant and stir until evenly dissolved.

[0046] (3) Add 0.7 g of lactic acid while stirring and stir until dissolved.

[0047] (4) Add 0.3 g of coconut amide propyl amine oxide while stirring and stir until dissolved.

[0048] Test example:

[0049] To verify the safety, non-irritation and antibacterial effects of the product of the present invention, it was determined by a third-party authoritative testing agency. Take the cleaning and antibacterial liquid of Example 1 for bactericidal effect test, single-dose complete skin irritation test, and single-dose vaginal mucosa irritation test.

[0050] The process and results of the test are as follows:

[0051] Detection method: According to GB15979-2002 "Hygienic Standards for Disposable Sanitary Products", the action time is 2, 5, 10, 20 minutes.

[0052] (1) The test results are shown in Table 1 below:

[0053] Table 1. Bacteriostatic effect of the sample on test strains

[0054]

[0055] Test conclusion: The test samples have a bacteriostatic rate > 99.9% against Candida albicans, Staphylococcus aureus, and Escherichia coli after acting for 2, 5, 10, 20 minutes, showing a strong bacteriostatic effect.

[0056] (2) The results of the single-dose complete skin irritation test of the sample cleaning and antibacterial liquid are shown in Table 2 below.

[0057] Table 2. Scoring of the single-dose complete skin irritation reaction of the test substance on New Zealand rabbits

[0058]

[0059] Test conclusion: The average irritation index of the test substance in the multiple skin irritation test on rabbits is 0.00, indicating no irritation to the single-dose complete skin.

[0060] (3) The results of the single-dose vaginal mucosa irritation test of the sample cleaning and antibacterial liquid are shown in Table 3 below.

[0061] Table 3. Scoring results of the single-dose vaginal mucosa irritation reaction of the test substance on rabbits

[0062]

[0063]

[0064] Test conclusion: The irritation reaction intensity of the test substance to the vaginal mucosa of rabbits is: none.

[0065] As mentioned above, it is only the preferred embodiment of the present invention, and it does not impose any formal or substantial limitations on the present invention. It should be pointed out that for those of ordinary skill in the art of this technology, without departing from the method of the present invention, several improvements and supplements can still be made, and these improvements and supplements should also be regarded as the protection scope of the present invention. Any equivalent changes made by those who are familiar with the technology in this field, without departing from the spirit and scope of the present invention, by making some changes, modifications and evolutions using the technical content disclosed above, are all equivalent embodiments of the present invention; at the same time, any equivalent changes, modifications and evolutions made to the above embodiments based on the substantial technology of the present invention still fall within the scope of the technical solution of the present invention.

Claims

1. A cleaning and bacteriostatic liquid, characterized in that, By weight parts, it includes 0.1 - 3.0 parts of lactic acid, 1.0 - 8.0 parts of ammonium lauryl ether sulfate, 1.0 - 7.0 parts of fatty alcohol polyoxyethylene ether glucoside, 0.5 - 8.0 parts of coconut oil diethanolamide, 0.1 - 0.8 parts of coconut amide propyl amine oxide, 0.1 - 1.0 part of humectant and 80.0 - 98 parts of purified water; The humectant is one or several mixtures of glycerol, propylene glycol and polyethylene glycol; When the cleaning and bacteriostatic liquid acts for 2 minutes, the bacteriostatic rates against Candida albicans, Staphylococcus aureus and Escherichia coli are ≥ 99.9%; 2. The cleaning and bacteriostatic liquid according to claim 1, wherein By weight parts, the cleaning and bacteriostatic liquid includes 0.3 - 1.5 parts of lactic acid, 2.0 - 6.0 parts of ammonium lauryl ether sulfate, 2.0 - 5.0 parts of fatty alcohol polyoxyethylene ether glucoside, 1.0 - 6.0 parts of coconut oil diethanolamide, 0.2 - 0.6 parts of coconut amide propyl amine oxide, 0.1 - 0.8 part of humectant and 84.0 - 95 parts of purified water.

3. The cleaning and bacteriostatic liquid according to claim 1, wherein By weight parts, the cleaning and bacteriostatic liquid includes 0.3 - 1.0 parts of lactic acid, 2.0 - 5.0 parts of ammonium lauryl ether sulfate, 2.0 - 4.0 parts of fatty alcohol polyoxyethylene ether glucoside, 2.0 - 5.0 parts of coconut oil diethanolamide, 0.2 - 0.5 parts of coconut amide propyl amine oxide, 0.1 - 0.5 part of humectant and 84.0 - 93.4 parts of purified water.

4. A method for preparing a cleaning and antibacterial liquid according to any one of claims 1-3, characterized in that, The preparation method includes the following steps: 1) Add purified water into a container, and add ammonium lauryl ether sulfate, fatty alcohol polyoxyethylene ether glucoside and coconut oil diethanolamide, and stir until completely dissolved; 2) While stirring, add the humectant into the system of step 1) and stir evenly until dissolved; 3) While stirring, add lactic acid into the system of step 2) and stir until dissolved; 4) Adjust the pH; 5) While stirring, add coconut amide propyl amine oxide into the system of step 4) and stir until dissolved to obtain the cleaning and bacteriostatic liquid.

5. The preparation method of the cleaning and bacteriostatic liquid according to claim 4, characterized in that, In step 4), the pH is adjusted to 4.5 - 7.

6. The preparation method of the cleaning and bacteriostatic liquid according to claim 4, characterized in that, In steps 1) - 5), the stirring speed is 200 - 400 revolutions per minute.

Images