A solid-liquid composite multifunctional bionic intervertebral disc

Abstract

A solid-liquid composite multifunctional bionic intervertebral disc belongs to the technical field of bionic intervertebral discs. The upper end plate assembly, core layer and lower end plate assembly of the present invention are arranged in sequence from top to bottom and fixedly connected; the upper end plate assembly and the lower end plate assembly have the same structure, and the end plates are provided with coatings, nail tooth groups and micropore groups; the core layer is composed of a nucleus pulposus, a transition ring and four fibrous rings arranged and fixedly connected from the inside to the outside, and the nucleus pulposus is made of a low-acyl gel and agarose of a liquid core injected into a cellulose sponge of a solid skeleton of a soft support structure; the surfaces of the transition ring and the four fibrous rings are coated with collagen fibers, and the slopes of the collagen fibers of each two layers are staggered with each other; the present invention has cushioning and shock absorption, dynamic anti-fatigue functions, good spinal motion matching and anti-compression and anti-shear mechanical properties.

Description

Technical Field

[0001] The present invention belongs to the technical field of bionic intervertebral discs, and in particular relates to a solid-liquid composite multifunctional bionic intervertebral disc. Background Art

[0002] Currently, an increasing number of people suffer from chronic low back pain, and intervertebral disc disease and degeneration are the main causes of chronic low back pain. The early stages of intervertebral disc degeneration are mainly treated with physical therapy or traditional medications, while the later stages of degeneration are mainly treated with surgery, such as spinal fusion and total disc replacement. Spinal fusion can cause loss of vertebral segmental motion and accelerate degenerative changes in adjacent vertebral segments. Total disc replacement, on the other hand, preserves the range of motion of the vertebral segments while significantly reducing the risk of adjacent segment degeneration. This effectively addresses the shortcomings of fusion, making it a more advanced and effective treatment option.

[0003] Commonly used artificial intervertebral discs worldwide today primarily utilize two designs: ball-and-socket joints and viscoelastic integrated discs. Ball-and-socket joint discs utilize metal-metal, polymer-polymer, or metal-polymer materials. Because they utilize a single solid-phase material, they lack optimal cushioning and shock absorption, dynamic fatigue resistance, and fail to adequately match the physiological range of motion of the spine. This results in abnormal loads on non-vertebral joints and facet joints, leading to abnormal degeneration of these joints in the treated and adjacent segments. Viscoelastic integrated discs achieve motion through elastic deformation of the material, helping to reduce excessive stress and slow degeneration of these joints. However, viscoelastic materials primarily utilize hydrogels. Hydrogels have high water content and viscoelastic properties, similar to those of the human nucleus pulposus. However, without reinforcement, hydrogels often fail under mechanical loads (such as compression and shear). Literature research has found that pure hydrogels are insufficient to restore the disc's mechanical properties against compression and shear. Compression and shear loads are crucial because they are the primary loads acting on the intervertebral disc in daily life. The aforementioned deficiencies of existing artificial intervertebral discs can lead to problems such as sinking and dislocation after implantation, and can even necessitate secondary revision surgery, causing significant pain for patients. Therefore, there is an urgent need to address the issue of existing artificial intervertebral discs not being able to simultaneously possess multifunctional properties such as cushioning and shock absorption, dynamic fatigue resistance, good spinal motion matching, and mechanical properties such as compression and shear resistance, so that the artificial intervertebral disc can restore the original mechanical and biological properties of a healthy spine. Summary of the Invention

[0004] The purpose of the present invention is to provide a solid-liquid composite multifunctional bionic intervertebral disc with cushioning and shock absorption, dynamic anti-fatigue functions, good spinal motion matching, and compression and shear resistance.

[0005] The present invention provides a solid-liquid composite multifunctional bionic intervertebral disc, the outer contour of which is the same as that of a human intervertebral disc, and the thickness of which is 6-10 mm. The bionic intervertebral disc is composed of an upper end plate component A, a core layer B and a lower end plate component C. The upper end plate component A is composed of an end plate I1, a spike group ID, a microporous group IE and a coating I2, wherein the spike group ID is composed of six spikes, and the six spikes are divided into two rows and symmetrically fixed to the left and right sides of the bb center line on the end plate I1; the microporous group IE is arranged at the upper center of the end plate I1; and the coating I2 is applied to the upper surface of the end plate I1.

[0006] The lower end plate assembly C is composed of an end plate II 11, a spike group IIG, a micropore group IIH and a coating II 12, wherein the spike group IIG is composed of six spikes, which are divided into two rows and symmetrically fixed to the left and right sides of the bb center line below the end plate II 11; the micropore group IIH is arranged at the center of the upper surface of the end plate II 11; and the coating II 12 is applied to the lower surface of the end plate II 11.

[0007] The spacing W between each row of teeth in both tooth groups ID and IIG and the centerline of the BB is the same: 0.8-1 cm. The spacing L6 between adjacent teeth in each row is 0.4-0.6 cm. The teeth are all conical, with a height H of 1.5 mm and a base diameter D of 1.5 mm.

[0008] The core layer B is composed of annulus fibrosus I4, annulus fibrosus II5, annulus fibrosus III6, annulus fibrosus IV7, transition annulus 8 and nucleus pulposus F, and annulus fibrosus I4, annulus fibrosus II5, annulus fibrosus III6, annulus fibrosus IV7, transition annulus 8 and nucleus pulposus F are arranged in sequence from outside to inside and fixedly connected. Collagen fiber groups are attached to the surfaces of annulus fibrosus I4, annulus fibrosus II5, annulus fibrosus III6, annulus fibrosus IV7 and transitional annulus 8, which are marked as collagen fiber group I3a, collagen fiber group II3b, collagen fiber group III3c, collagen fiber group IV3d and collagen fiber group V3e, respectively. Among them, the angle α1 between collagen fiber group I3a of annulus fibrosus I4, collagen fiber group III3c of annulus fibrosus III6 and collagen fiber group V3e of transitional annulus 8 and the anterior upper surface of endplate II11 is 20-40 degrees; the angle α2 between them and the posterior upper surface of endplate II11 is 50-70 degrees. The angle α1 to α2 increases gradually along the circumference of the annulus fibrosus, with a gradient of 3-7 degrees. In addition, collagen fiber group I3a and collagen fiber group III3c are symmetrically distributed on both sides of the centerline of the bb.

[0009] The collagen fiber group II3b of annulus fibrosus II 5 and the collagen fiber group IV3d of annulus fibrosus IV 7 are arranged in the same manner, in the opposite direction to the collagen fiber groups I3a, III3c, and V3e, that is, the angles α1 and α2 with endplate II 11 are complementary. The thickness L1 of annulus fibrosus I 4 is 1.5-2 mm, the thickness L2 of annulus fibrosus II 5 is 1-1.5 mm, the thickness L3 of annulus fibrosus III 6 is 0.5-1 mm, the thickness L4 of annulus fibrosus IV 7 is 0.2-0.5 mm, and the thickness L5 of transition ring 8 is 0.05-0.2 mm.

[0010] Nucleus pulposus F is composed of a soft support structure, solid skeleton 9, and a liquid core 10. The soft support structure, solid skeleton 9, is made of cellulose sponge, and the liquid core 10 is composed of low-acyl gel and agarose. The low-acyl gel and agarose of liquid core 10 are injected into the cellulose sponge of the soft support structure, solid skeleton 9, to form nucleus pulposus F. The upper endplate assembly A, core layer B, and lower endplate assembly C are arranged sequentially from top to bottom, with the upper end of core layer B affixed to the underside of endplate I1 in upper endplate assembly A. The lower end of core layer B affixed to the upper side of endplate II11 in lower endplate assembly C.

[0011] The micropore group IE and micropore group IIG have the same structure, both consisting of pore group I13, pore group II14, pore group III15, pore group IV16, pore group V17, pore group VI18, pore group VII19, and pore group VIII20, and arranged in a circular order from the inside to the outside; wherein: pore group I13 has 7 pores, pore group II14 has 8 pores, and pore groups III15 to VIII20 each have 10 pores; the pore diameters of pore group I13 are all 8-10 μm, and are arranged in a petal shape with a as the center point; the pores of pore groups II14 to VIII20 are arranged in a circular shape with a as the center point, and the pore diameters of pore group II14 are all 6-8 μm; pore group III15 The pore diameters of hole group IV16 are all 2-4μm; the pore diameters of hole group V17 are all 1-2μm; the pore diameters of hole group VI18 are all 0.5-1μm; the pore diameters of hole group VII19 are all 0.25-0.5μm, and there are 10 of them; the pore diameters of hole group VIII20 are all 0.1-0.2μm; the holes of hole group I13, hole group II14, hole group III15, and hole group IV16 are through holes, and the holes of hole group V17, hole group VI18, hole group VII19, and hole group VIII20 are blind holes, with depths of 0.75mm, 0.5mm, 0.25mm, and 0.05mm, respectively.

[0012] The connection angle β between the collagen fiber group I3a and the end plate I1 is 100-150 degrees, and the connection angles β on the left and right sides of the bb center line are symmetrically distributed; the connection angle between the collagen fiber group I3a and the end plate II11 is the same as that of the end plate I1.

[0013] The end plates I1 and II11 have the same thickness, with a center thickness of 0.8±0.2 mm and an edge thickness of 1.2±0.2 mm. The thickness increases gradually from the center to the edge of the end plate, with a gradient of 0.05-0.5 mm.

[0014] The end plates I1 and II11 contain fiber layers 21, and the fiber layers 21 are parallel to the horizontal plane.

[0015] The material of the end plate I1 and the end plate II11 is polyetheretherketone polymer; the material of the annulus fibrosus I4, annulus fibrosus II5, annulus fibrosus III6, annulus fibrosus IV7 and transition ring 8 are all polycarbonate polyurethane; the material of the collagen fiber 3 is ultra-high molecular polyethylene; the material of the coating I2 and the coating II12 are both hydroxyapatite.

[0016] The beneficial effects of the present invention are as follows:

[0017] 1. The nucleus pulposus is made of liquid-based materials and has the material properties of both solid and liquid phases, which enables the bionic intervertebral disc to have multifunctional characteristics such as cushioning and shock absorption, dynamic anti-fatigue, and good spinal motion matching.

[0018] 2. The nucleus pulposus is prepared using a liquid-based material, with a cellulose sponge material serving as the soft support structure and a hydrogel composed of low-acyl gelatin and agarose serving as the liquid material. The low-acyl gelatin and agarose are then injected into the cellulose sponge to create the nucleus pulposus. By varying the concentrations of the low-acyl gelatin and agarose in the mixture, the viscoelastic and mechanical properties of the nucleus pulposus can be manipulated.

[0019] 3. The connection angle between the collagen fibers in the annulus fibrosus and the end plate is 100-150 degrees. The multi-layer annulus fibrosus forms an onion-like structure, which can better support the hydrostatic pressure generated in the nucleus pulposus, making the entire bionic intervertebral disc have better mechanical properties of resistance to compression and shear.

[0020] 4. The thickness of the endplate varies from the center to the edge, gradually increasing from the center to the edge. The thickness above the nucleus pulposus is slightly lower than that above the annulus fibrosus. The endplate has a microporous channel structure with varying diameters, gradually decreasing from the center to the edge. Compared to the surrounding area, the center of the endplate is permeable. Furthermore, the upper and lower endplates contain fibrous layers that extend horizontally and parallel to each other, giving the endplates improved mechanical properties. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Figure 1 This is a three-dimensional image of a solid-liquid composite multifunctional bionic intervertebral disc;

[0022] Figure 2 Schematic diagram of the structure of the upper end plate assembly A;

[0023] Figure 3 This is the front view of the solid-liquid composite multifunctional bionic intervertebral disc;

[0024] Figure 4 for Figure 3 A cross-sectional view of section AA in FIG;

[0025] Figure 5 Schematic diagram of the structure of nucleus pulposus F;

[0026] Figure 6 Schematic diagram of the structure of the lower end plate assembly C;

[0027] Figure 7 Schematic diagram of the structure of the cross section of the microporous group;

[0028] Figure 8 It is a structural schematic diagram of the longitudinal section of the microporous group;

[0029] Figure 9 Schematic diagram of the connection between the collagen fiber group and the upper end plate;

[0030] Figure 10 It is a structural diagram of the distribution of the spike tooth group;

[0031] Figure 11 Schematic diagram of the structure of the nail teeth;

[0032] Among them: A. Upper endplate assembly B. Core layer C. Lower endplate assembly D. Tooth group I E. Microporous group I F. Nucleus pulposus G. Tooth group II H. Microporous group II 1. Endplate I 2. Coating I 3a. Collagen fiber group I 3b. Collagen fiber group II 3c. Collagen fiber group III 3d. Collagen fiber group IV 3e. Collagen fiber group V 4. Annulus fibrosus I 5. Annulus fibrosus II 6. Annulus fibrosus III 7. Annulus fibrosus IV 8. Transition ring 9. Soft support structure solid skeleton 10. Liquid core 11. Endplate II 12. Coating II 13. Pore group I 14. Pore group II 15. Pore group III 16. Pore group IV 17. Pore group V 18. Pore group VI 19. Pore group VII 20. Pore group VIII 21. Fibrous layer. DETAILED DESCRIPTION

[0033] The present invention will be described below with reference to the accompanying drawings.

[0034] like Figure 1 Figure 2 and Figure 6As shown, the present invention is a solid-liquid composite multifunctional bionic intervertebral disc, the outer contour of the intervertebral disc is the same as the outer contour of the human intervertebral disc, and its thickness is 6-10mm. The bionic intervertebral disc is composed of an upper end plate component A, a core layer B and a lower end plate component C. The upper end plate component A is composed of an end plate Ⅰ1, a spike group ⅠD, a microporous group ⅠE and a coating Ⅰ2, wherein the spike group ⅠD is composed of six spikes, and the six spikes are divided into two rows and symmetrically fixed to the left and right sides of the bb center line on the end plate Ⅰ1; the microporous group ⅠE is arranged at the upper center of the end plate Ⅰ1; and the coating Ⅰ2 is applied to the upper surface of the end plate Ⅰ1.

[0035] The lower endplate assembly C comprises endplate II11, spike group IIG, microporous group IIH, and coating II12. Spike group IIG consists of six spikes arranged in two rows, symmetrically attached to the left and right sides of the BB centerline below endplate II11. Microporous group IIH is located at the center of the upper surface of endplate II11. Coating II12 is applied to the lower surface of endplate II11. Spike groups ID and IIG provide excellent initial fixation after bionic disc implantation.

[0036] The materials of coating I2 and coating II12 are both hydroxyapatite. Since hydroxyapatite coating has an affinity for bone tissue, it can induce undifferentiated mesenchymal cells to differentiate into osteocytes, thereby achieving the purpose of secondary fixation of the intervertebral disc.

[0037] like Figure 10 and 11 As shown, the spacing W between the two rows of teeth in both tooth groups ID and IIG and the centerline of the BB is the same: 0.8-1 cm. The spacing L6 between adjacent teeth in each row is 0.4-0.6 cm. The teeth are all conical, with a height H of 1.5 mm and a base diameter D of 1.5 mm.

[0038] like Figure 4As shown, the core layer B is composed of annulus fibrosus I4, annulus fibrosus II5, annulus fibrosus III6, annulus fibrosus IV7, transition annulus 8 and nucleus pulposus F, and annulus fibrosus I4, annulus fibrosus II5, annulus fibrosus III6, annulus fibrosus IV7, transition annulus fibrosus 8 and nucleus pulposus F are arranged in sequence from outside to inside and fixed; the surfaces of annulus fibrosus I4, annulus fibrosus II5, annulus fibrosus III6, annulus fibrosus IV7 and transition annulus 8 are all attached with collagen fiber groups, which are marked as collagen fiber group I3a, collagen fiber group II3b, collagen fiber group III3c, collagen fiber group The collagen fibers of annulus fibrosus (Annulus fibrosus) group I3a, group III3c of annulus fibrosus (Annulus fibrosus) group III3c, and group V3e of transitional annulus fibrosus (Annulus fibrosus) group V3e have angles α1 of 20-40 degrees with the anterior superior surface of endplate II11, and α2 of 50-70 degrees with the posterior superior surface of endplate II11. The angles α1 to α2 increase gradually along the circumference of the annulus fibrosus, with a gradient of 3-7 degrees. Collagen fibers group I3a and group III3c are symmetrically distributed on either side of the bb centerline. Collagen fibers group II3b of annulus fibrosus (Annulus fibrosus) group II3d of annulus fibrosus (Annulus fibrosus) group IV3d are arranged in the same manner, in the opposite direction to collagen fibers group I3a, group III3c, and group V3e, thus complementing the angles α1 and α2 of endplate II11. The thickness L1 of annulus fibrosus I 4 is 1.5-2mm, the thickness L2 of annulus fibrosus II 5 is 1-1.5mm, the thickness L3 of annulus fibrosus III 6 is 0.5-1mm, the thickness L4 of annulus fibrosus IV 7 is 0.2-0.5mm, and the thickness L5 of transition ring 8 is 0.05-0.2mm. The multiple layers of annulus fibrosus better support the hydrostatic pressure generated in the nucleus pulposus, giving the entire bionic intervertebral disc improved mechanical properties against compression and shear. The transition ring 8 tightly connects the outer annulus fibrosus with the inner nucleus pulposus, acting as a transition.

[0039] like Figure 4 and 5 As shown, the nucleus pulposus F is composed of a soft support structure solid skeleton 9 and a liquid core 10. The material of the soft support structure solid skeleton 9 is cellulose sponge, and the liquid core 10 is composed of low acyl gel and agarose. The low acyl gel and agarose of the liquid core 10 are injected into the cellulose sponge of the soft support structure solid skeleton 9 to make the nucleus pulposus F. The nucleus pulposus prepared from liquid-based materials can take into account the characteristics of both solid and liquid phase materials, and has unique advantages in terms of cushioning and shock absorption, dynamic anti-fatigue, and good spinal motion matching. The soft support structure solid skeleton cellulose sponge material has many advantages, such as biocompatibility, non-cytotoxicity, non-sensitization, non-irritation to the skin, and non-decomposition. At the same time, the solid skeleton can enhance the mechanical properties of the nucleus pulposus, such as compression resistance and shear resistance. The liquid-based material can regulate the viscoelastic properties and mechanical properties of the nucleus pulposus by changing the concentration of low acyl gel and agarose in the mixture.

[0040] The upper endplate assembly A, core layer B, and lower endplate assembly C are arranged sequentially from top to bottom, wherein the upper end of the core layer B is fixed to the lower surface of the endplate I1 in the upper endplate assembly A. The lower end of the core layer B is fixed to the upper surface of the endplate II11 in the lower endplate assembly C.

[0041] like Figure 7 and 8 As shown, the structures of the micropore group IE and the micropore group IIG are the same, both consisting of pore group I13, pore group II14, pore group III15, pore group IV16, pore group V17, pore group VI18, pore group VII19, and pore group VIII20, and arranged in a circular order from the inside to the outside; wherein: pore group I13 has 7 pores, pore group II14 has 8 pores, and pore groups III15 to VIII20 each have 10 pores; the pore diameters of pore group I13 are all 8-10 μm, and are arranged in a petal shape with a as the center point; the pores of pore groups II14 to VIII20 are arranged in a circular shape with a as the center point, and the pore diameters of pore group II14 are all 6-8 μm; The diameters of the holes in hole group 15 are all 4-6 μm; the diameters of the holes in hole group IV 16 are all 2-4 μm; the diameters of the holes in hole group V 17 are all 1-2 μm; the diameters of the holes in hole group VI 18 are all 0.5-1 μm; the diameters of the holes in hole group VII 19 are all 0.25-0.5 μm, and there are 10 of them; the diameters of the holes in hole group VIII 20 are all 0.1-0.2 μm; the holes in hole group I 13, hole group II 14, hole group III 15, and hole group IV 16 are through holes, and the holes in hole group V 17, hole group VI 18, hole group VII 19, and hole group VIII 20 are blind holes, with depths of 0.75 mm, 0.5 mm, 0.25 mm, and 0.05 mm, respectively.

[0042] Compared with the peripheral area of ​​the end plate, the through holes in the central part are permeable, so that the nucleus pulposus can absorb the liquid such as water that penetrates through it, similar to the human nucleus pulposus's ability to transfer nutrients such as water.

[0043] like Figure 9 As shown, the connection angle β between the collagen fiber group I3a and the end plate I1 is 100-150 degrees, and the connection angles β on the left and right sides of the bb center line are symmetrically distributed; the connection angle between the collagen fiber group I3a and the end plate II11 is the same as that of the end plate I1.

[0044] The end plates I1 and II11 have the same thickness, with a center thickness of 0.8±0.2 mm and an edge thickness of 1.2±0.2 mm. The thickness increases gradually from the center to the edge of the end plate, with a gradient of 0.05-0.5 mm.

[0045] The end plates I1 and II11 contain fiber layers 21, and the fiber layers 21 are parallel to the horizontal plane, thereby increasing the mechanical properties of the end plates and avoiding problems such as breakage or sinking of the end plates.

[0046] The material of the end plate I1 and the end plate II11 is polyetheretherketone polymer; the material of the annulus fibrosus I4, annulus fibrosus II5, annulus fibrosus III6, annulus fibrosus IV7 and transition ring 8 are all polycarbonate polyurethane; the material of the collagen fiber 3 is ultra-high molecular polyethylene.

Claims

1. A solid-liquid composite multifunctional bionic intervertebral disc, the outer contour of which is the same as that of a human intervertebral disc, and the thickness of which is 6-10 mm, characterized by: The bionic intervertebral disc is composed of an upper end plate component (A), a core layer (B) and a lower end plate component (C), wherein the upper end plate component (A) is composed of an end plate I (1), a spike group I (D), a microporous group I (E) and a coating I (2), wherein the spike group I (D) is composed of six spikes, which are divided into two rows and symmetrically fixed to the left and right sides of the bb center line on the end plate I (1); the microporous group I (E) is located at the center of the upper end of the end plate I (1); the coating I (2) is applied to the upper surface of the end plate I (1); the lower end plate component (C) is composed of the end plate I (1), the spike group I (D), the microporous group I (E) and the ...) are applied to the upper surface of the end plate I (1); the lower end plate component (C) is composed of the end plate I (1), the spike group I (D), the microporous group I (E) and the coating I (2) are applied to the upper surface of the end plate I (1); the upper end plate component (A) is composed of the end plate I (1), the spike group I (D), the microporous group I (E) and the coating I (2) are applied to the upper surface of the end plate I (1); the upper end plate component (A) is composed of the end plate I (1), the spike group I (D), the microporous group I (E) and the coating I (2) are applied to the The invention is composed of a plate II (11), a spike group II (G), a microporous group II (H) and a coating II (12), wherein the spike group II (G) is composed of six spikes, which are divided into two rows and symmetrically fixed on the left and right sides of the bb center line below the end plate II (11); the microporous group II (H) is located at the center of the upper surface of the end plate II (11); the coating II (12) is applied to the lower surface of the end plate II (11); the spacing W between the two rows of spikes in the spike group I (D) and the spike group II (G) and the bb center line is the same, both of which are: 0.8-1cm; the adjacent spikes in each row of spikes are The spacing L6 of the teeth is: 0.4-0.6cm; the nail teeth are all cones, the height H of each nail tooth is 1.5mm, and the bottom circle diameter D is 1.5mm; the core layer (B) is composed of annulus fibrosus I (4), annulus fibrosus II (5), annulus fibrosus III (6), annulus fibrosus IV (7), transition annulus (8) and nucleus pulposus (F), and annulus fibrosus I (4), annulus fibrosus II (5), annulus fibrosus III (6), annulus fibrosus IV (7), transition annulus (8) and nucleus pulposus (F) are arranged in sequence from outside to inside and fixed; annulus fibrosus I (4), annulus fibrosus II ( 5), annulus fibrosus III (6), annulus fibrosus IV (7) and transitional annulus (8) are all attached with collagen fiber groups, which are marked as collagen fiber group I (3a), collagen fiber group II (3b), collagen fiber group III (3c), collagen fiber group IV (3d) and collagen fiber group V (3e), respectively; among them, the angle α1 between the collagen fiber group I (3a) of annulus fibrosus I (4), the collagen fiber group III (3c) of annulus fibrosus III (6) and the collagen fiber group V (3e) of transitional annulus (8) and the upper surface of the front of end plate II (11) is 20-40 degrees; The angle α2 with the upper surface of the posterior part of the end plate II (11) is 50-70 degrees, and the angle α1 to α2 increases gradually along the circumference of the annulus fibrosus, with a gradient of 3-7 degrees, and the collagen fiber group I (3a) and collagen fiber group III (3c) are symmetrically distributed on both sides of the center line of the bb; the collagen fiber group II (3b) of the annulus fibrosus II (5) and the collagen fiber group IV (3d) of the annulus fibrosus IV (7) are arranged in the same way, and are opposite to the direction of collagen fiber group I (3a), collagen fiber group III (3c) and collagen fiber group V (3e), that is, they are complementary to the angles α1 and α2 of the end plate II (11); the thickness L1 of the annulus fibrosus I (4) is 1.5-2mm, the thickness L2 of the annulus fibrosus II (5) is 1-1.5mm, the thickness L3 of the annulus fibrosus III (6) is 0.5-1mm, and the thickness L4 of the annulus fibrosus IV is 0. The thickness L4 of (7) is 0.2-0.5mm, and the thickness L5 of the transition ring (8) is 0.05-0.2mm; the nucleus pulposus (F) is composed of a soft support structure solid skeleton (9) and a liquid core (10), wherein the material of the soft support structure solid skeleton (9) is cellulose sponge, and the liquid core (10) is composed of low acyl gel and agarose, and the low acyl gel and agarose of the liquid core (10) are injected into the cellulose sponge of the soft support structure solid skeleton (9) to make the nucleus pulposus (F); the upper end plate assembly (A), the core layer (B) and the lower end plate assembly (C) are arranged in sequence from top to bottom, wherein the upper end of the core layer (B) is fixed to the bottom of the end plate I (1) in the upper end plate assembly (A); and the lower end of the core layer (B) is fixed to the top of the end plate II (11) in the lower end plate assembly (C).

2. The solid-liquid composite multifunctional bionic intervertebral disc according to claim 1, characterized in that: The micropore group I (E) and micropore group II (H) have the same structure, both consisting of pore group I (13), pore group II (14), pore group III (15), pore group IV (16), pore group V (17), pore group VI (18), pore group VII (19), and pore group VIII (20), and arranged in a circular order from the inside to the outside; wherein: pore group I (13) has 7 pores, pore group II (14) has 8 pores, and pore group III (15) to pore group VIII (20) each has 10 pores; the pore diameters of pore group I (13) are all 8-10 μm, and are arranged in a petal shape with a as the center point; the pores of pore group II (14) to pore group VIII (20) are arranged in a circular shape with a as the center point, and the pore diameters of pore group II (14) are all 6-8 μm; The pore diameters of group III (15) are all 4-6 μm; the pore diameters of group IV (16) are all 2-4 μm; the pore diameters of group V (17) are all 1-2 μm; the pore diameters of group VI (18) are all 0.5-1 μm; the pore diameters of group VII (19) are all 0.25-0.5 μm, and there are 10 pores in the group; the pore diameters of group VIII (20) are all 0.1-0.2 μm; the pores of group I (13), group II (14), group III (15), and group IV (16) are through holes, and the pores of group V (17), group VI (18), group VII (19), and group VIII (20) are blind holes, with depths of 0.75 mm, 0.5 mm, 0.25 mm, and 0.05 mm, respectively.

3. The solid-liquid composite multifunctional bionic intervertebral disc according to claim 1, characterized in that: The connection angle β between the collagen fiber group I (3a) and the end plate I (1) is 100-150 degrees, and the connection angles β on the left and right sides of the bb center line are symmetrically distributed; the connection angle between the collagen fiber group I (3a) and the end plate II (11) is the same as that of the end plate I (1).

4. The solid-liquid composite multifunctional bionic intervertebral disc according to claim 1, characterized in that: The end plate I (1) and the end plate II (11) have the same thickness, with the center thickness of both being 0.8±0.2 mm and the edge thickness being 1.2±0.2 mm. The thickness increases gradually from the center to the edge of the end plate, with a gradient of 0.05-0.5 mm.

5. The solid-liquid composite multifunctional bionic intervertebral disc according to claim 1, characterized in that: The end plate I (1) and the end plate II (11) have fiber layers (21) therein, and the fiber layers (21) are parallel to the horizontal plane.

6. The solid-liquid composite multifunctional bionic intervertebral disc according to claim 1, characterized in that: The material of the end plate I (1) and the end plate II (11) is polyetheretherketone polymer; the material of the annulus fibrosus I (4), annulus fibrosus II (5), annulus fibrosus III (6), annulus fibrosus IV (7) and transition ring (8) are all polycarbonate polyurethane; the material of the collagen fiber (3) is ultra-high molecular polyethylene; the material of the coating I (2) and the coating II (12) are both hydroxyapatite.

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