Improved administration device

Abstract

The invention relates to an administration device for administering a medicament. The administration device comprises a housing, a reservoir and a drive device with a movable piston rod. The piston rod is guided through a passage in an inner wall or an outer wall of the housing. The passage is sealed but allows movement of the piston rod. The peripheral shape of the cross section of the piston rod is approximately non-trivially constant.

Description

Technical Field

[0001] This invention relates to the field of administration devices (or delivery instruments, i.e., Verabreichungsgeräte) and administration apparatuses for fluid drugs, particularly injection or syringe devices. In particular, this invention relates to administration devices having a movable piston rod. Background Technology

[0002] Delivery devices for fluids, especially liquid medications, are known to be diverse, ranging from simple disposable syringes to injection pens to complex delivery devices. Especially in the case of reusable delivery devices, protecting critical components (such as actuators or electronics) from liquid ingress is important for the device's durability.

[0003] The following explanation uses an insulin pump as an example to illustrate the problem. However, problems can arise even with reusable pens and other administration devices, so the following explanation should not be interpreted in a restrictive manner.

[0004] For example, the applicant's Ypsopump is known from existing technology. Ypsopump is a conventional insulin pump that can be used to deliver insulin from a standard capreol. Figures 1 to 3 It displays the entire Ypsopump, or a region of it.

[0005] Figures 1 to 3 Prior art previously known, as illustrated in the background description, is shown. It is taken from EP3110475B1, which is incorporated herein by reference in its entirety.

[0006] Figure 1 The Ypsopump p1 is shown in perspective view. From the outside, the housing p5 with the observation window p6 is visible, through which the Capule p2 can be controlled (see [link to Capule p2]). Figure 2 The status of the input adapter is also visible. Operation buttons p10 and a display p20 (a touchscreen display) can also be seen. Input adapter p30 and input hose p31 are also visible.

[0007] Figure 2 The image shows a cross-section passing through the Ypsopump p1 and the input adapter p30. For an explanation of how the Ypsopump p1 works, please refer to [link / reference needed]. Figure 2Briefly, the Capule P2 has an open end that is closed by a movable, supported plunger P4. At its second end, the Capule P2 is closed by a diaphragm P3. The cannula P30a of the infusion adapter P30 can puncture this diaphragm, allowing medication (insulin) to pass through the cannula P30a to the infusion tubing P31 and ultimately be administered subcutaneously to the patient. The plunger P4 is actuated by a piston rod P52. Figure 2 The complete Capule p2 is shown here, with the piston rod p52 fully retracted accordingly. The piston rod p52 is driven by a motor p40, which is connected to the piston rod p52 via a gearbox p45 and a drive sleeve 51. The piston rod p52 is torsionally but axially movable to its anti-torsion portion p50a of the drive housing p50. Since the drive housing p50 is firmly arranged within the housing p5, the piston rod p52 is also torsionally fixed relative to the housing p5. The drive sleeve p51 has threads on its inner side p52b, which are threaded into contact with the proximal end of the piston rod p52. If the drive sleeve p51 rotates about its axis, the piston rod p52 moves proximally or distally due to the presence of the anti-torsion portion (see above).

[0008] Figure 2 A battery case p91 is further shown, comprising a battery p90, a negative terminal connection p93, and a positive terminal connection p92. The positive terminal connection p92 is part of the battery case cover p7. Figure 2 The electronic device p80 was also symbolically shown.

[0009] The input adapter p30 holds the Capule p2 in the input pump p1 and secures it to the Ypsopump p1 via a bayonet connector. However, the input adapter does not provide a waterproof seal for the Capule box p9.

[0010] To protect sensitive areas of the Ypsopump p1, such as the electronics p80 or motor p40, from liquid ingress, various sealing elements, especially O-rings, are arranged within the Ypsopump p1. p54 and p60 provide protection on the actuator side / Capel box. P92a and p93 provide protection on the battery box side. The sliding support between the piston rod p52 and the anti-torsion section p50a is not liquid-tight, making the area between the piston rod p52 and the rotating sleeve p51 potentially susceptible to contamination—potential for further improvements.

[0011] like Figure 3 As can be seen, the longitudinal groove p52a is arranged for the anti-torsion portion of the piston rod p52, into which the anti-torsion portion p50a (protrusion) engages. This groove / protrusion anti-torsion portion makes it difficult to locate a truly sealing elastic sealing element in this area, which also functions as a support, while simultaneously allowing the piston rod p52 to slide within the pump p1.

[0012] Alternatively, piston rods with angular cross-sections (square, rectangular) are also known to achieve torsional resistance. However, even in these classic shapes, sealing problems arise because the supporting pressure of the seals arranged around the cross-section reaches its maximum at the corners and is weaker at the edges, thus posing a significant risk of leakage.

[0013] In this context, the terms "product," "drug," or "pharmaceutical substance" include any flowable pharmaceutical formulation suitable for controlled administration into subcutaneous or muscular tissue via cannula or needle, such as a liquid, solution, gel, or fine suspension containing one or more active pharmaceutical ingredients. Thus, a drug can be a composition having a single active ingredient or a premixed or co-formulated composition having multiple active ingredients from a single container. The term particularly includes pharmaceutical products such as peptides (e.g., insulin, insulin-containing drugs, GLP1-containing and derivative- or similar formulations), proteins and hormones, biologically derived or active active ingredients, hormone- or gene-based active ingredients, nutritional formulations, enzymes, and other substances in solid (suspension) or liquid form. The term also includes polysaccharides, vaccines, DNS or RNA or oligonucleotides, antibodies or portions of antibodies, and suitable bases, excipients, and carriers.

[0014] The term "distal" refers to the side or direction facing the insertion end of the delivery device towards the front or towards the tip of the injection needle. Conversely, "proximal" refers to the side or direction facing the rear end of the delivery device opposite the insertion end.

[0015] The terms “giving instrument” and “giving device” are used synonymously in this document. Summary of the Invention

[0016] The object of the present invention is to provide an improved feeding device with a conventional piston rod propulsion mechanism, wherein the components must be protected against liquid.

[0017] This objective is achieved by the giving means according to the independent claim. Advantageous embodiments of the invention are disclosed in the dependent claims, the description, and the drawings.

[0018] One aspect of the invention relates to a delivery device for a fluid drug or product as defined above. The delivery device can be an injection device, such as an injection pen, or an infusion device. In the case of an infusion device, it particularly includes insulin pumps and patch pumps (or patch pumps), and in the case of injection devices, it also includes autoinjectors, pens for automatically and repeatedly delivering individually adjustable doses (so-called auto-pens), and patch injectors. The delivery device can be configured as either integral or modular. A common feature of all devices according to the invention is the presence of an area of ​​the delivery device that should be protected against liquids. This may involve mechanical, electrical, electronic, magnetic, electromagnetic components, assemblies, or combinations thereof.

[0019] The feeding device according to the invention includes a housing, which may, but is not necessarily, composed of multiple modules. The modules themselves may be smaller housings.

[0020] In the housing of the delivery device, the reservoir may be at least partially disposed inside the housing. For example, the distal end of the reservoir through which the drug is delivered may be located outside the housing. The reservoir includes an internal volume that can be reduced to deliver the drug.

[0021] The reservoir can be a so-called capule in a broader sense, comprising a closed end with a diaphragm that can be punctured by a cannula. For example, it can be the cannula of an injection needle or an injector adapter. The capule is designed to open at its other end, with a movable plunger closing the open end. Thus, an internal volume is formed within the capule. This volume can be increased or decreased by moving the plunger. Various materialized portions (or shaped portions, or Materialisierungen) of capules made of glass or plastic are known to those skilled in the art, having circular or elliptical cross-sections, and respectively having linear or curved axes (e.g., toroidal).

[0022] Alternatively, the storage container can also be a bag that is squeezed out when the medication is administered.

[0023] The delivery device according to the invention also includes a drive mechanism. The drive mechanism is at least partially arranged within the housing or a module of the housing. When a reservoir is present, the drive mechanism is used to dispense the drug from the reservoir. The drive mechanism includes a driver. The driver serves as a source of mechanical energy. The driver can be a motor, especially an electric motor. Alternatively, and especially when the delivery device is a syringe, the driver can be an assembly of one or more springs. The task of the driver is to move a piston rod, which is also movably supported at least partially within the housing or partially within one or more modules. According to the invention, the piston rod is movably but non-rotatably supported directly or indirectly within the housing or module. The driver can be directly or indirectly coupled to the piston rod. In particular, when the driver is a motor, a gearbox (or transmission device, i.e., Getriebe) can be arranged between the driver and the motor, which converts the motor motion (typically a rotating driven shaft) into the movement of the piston rod. The coupling between the driver (directly or indirectly) and the piston rod can be achieved, for example, by a threaded connection between the driver and the piston rod. For example, the piston rod may have an internal thread that engages with the threaded rod or threaded mandrel of the drive. Due to the non-rotatability of the piston rod, rotation of the threaded rod or threaded mandrel causes movement of the piston rod. The threaded rod or threaded mandrel is advantageously the output element of the transmission between the motor and the piston rod.

[0024] For example, the piston rod can move the capillary plunger or pressurize the bag during its movement.

[0025] As mentioned, while the piston rod is movably supported, rotation about its own axis relative to the housing or the module supporting the piston rod is not possible. According to the invention, a through-hole is provided in the inner wall of the housing or in the wall of a module of the housing, and one or more anti-torsion elements are present in or within this through-hole. The piston rod is guided through this through-hole and movably supported therein. The through-hole can here be a polygonal opening through which the piston rod passes (the guide portion), and the polygonal shape generally describes the cross-section of the piston rod. In this way, an anti-torsion portion can be achieved similarly to the variant described above. Alternatively, an anti-torsion portion can be achieved using additional elements fixedly arranged at the through-hole. The wall can also be additionally mechanically reinforced in the through-hole region to additionally absorb forces acting on the wall. This can be achieved by increasing the wall thickness, by using rib-like reinforcements, or other methods known to those skilled in the art.

[0026] According to the invention, the through-hole is further provided with a seal that seals the area between the through-hole and the piston rod, such that when the piston rod is guided through the through-hole, no liquid can flow from one side of the wall through the through-hole to the other side. The seal is designed of a material that is at least elastically deformable and can seal the periphery of the piston rod at least by line contact. Ideally, the contact between the seal and the piston rod is not only linear but also extends along the piston rod axis, thereby creating a sealing surface. The mobility of the piston rod is preserved (advantageous in both directions for reusable appliances).

[0027] According to the invention, the piston rod has a specific cross-sectional shape, at least in the axial region through which it moves, enabling improved sealing. The shape of the cross-section here corresponds to a nontrivial orbiform curve (or Gliechdick). To illustrate what an orbiform curve is, a understandable definition is provided here by Wikipedia (https: / / de.wikipedia.org / wiki / Gleichdick):

[0028] "A region of constant thickness or constant width is visually represented as shown in the diagram below: it is of the same thickness or has the same width everywhere. The edges of such a figure are called constant width curves or orbiformes (“circles”).

[0029] The width of a curve is defined as the distance between two parallel straight lines that contact the curve on opposite sides. These straight lines refer to the supporting lines. A constant-width curve is one in which the distance between these lines always yields the same value, regardless of where the lines intersect in the graph.

[0030] The simplest, non-trivial, isothroat shape is a circle. The simplest non-trivial isothroat shape exhibiting the cross-sectional shape according to the invention is the so-called Luró triangle or circular arc triangle r1, such as... Figure 4a As shown in the image. Figure 4a The diagram also shows the equilateral triangle r2 used to construct the Lurlo triangle r1 and the radius R corresponding to the thickness of the isopleth and the side length of the triangle. Figure 4d The image shows a triangle of uniform thickness r5 with rounded corners. Figure 4b and 4c Its construction is shown. The corners are rounded with a radius r4, where the size of the radius |r4| corresponds to the additional application throughout the uniform thickness section, such that the thickness of the resulting uniform thickness can be calculated as R' = R + 2 * |r4|. r3 corresponds to the radius R plus |r4|, i.e., only once |r4|. Here, the size of the radius r3 can be assumed to be any size |r3|, where |r3| > R, and thus |r4| is derived from |r3| - R.

[0031] Between the Roulot triangle and the circle, there exist countless other isthickness shapes, which share with the Roulot triangle the characteristics of having an odd number of angles and convexity between the angles. As another example, the isthickness shape of the pentagon and its construction... Figures 5a to 5d As shown in the figure, 5d represents the completed uniform thickness shape r10. Figure 5a R11 is the pentagon, which serves as the starting point for the isothroat shape that forms the pentagon. R2 here is the radius of the arc r12 and corresponds to the thickness of the isothroat shape r10.

[0032] A shape of uniform thickness does not necessarily have to be equilateral like a Luró triangle. Certain rules must be followed during its construction, such as its...

[0033] https: / / web.archive.org / web / 202002230Q195l / http: / / www.mathematische-basteleien.de / Gleichdick.htm

[0034] Accessible below (archived on February 23, 2020 at archive.org). The protruding curved side is located at the center of the seal in the through section, thereby enabling a more regular pressure distribution within the seal (or surface pressure acting on the piston rod). However, this cross-sectional shape allows for the implementation of a torsional section.

[0035] In one aspect of the invention, the wall region having the through-hole is implemented as a two-component injection-molded part. The load-bearing portion, i.e., the actual wall, is injection-molded from a first material (first component, technically also referred to as a preform), and the sealing portion is injection-molded from at least an elastically deformable second material (second component). On one hand, this process allows the wall region to be created with a suitable seal in a single step. On the other hand, the wall region may also include additional through-holes, which can also be sealed in the same step. Advantageously, this can relate to seals for operating elements (buttons) or seals for electrical leads.

[0036] In one design, the material used for the second component is injection moldable, particularly thermoplastic, polyurethane, or polyamide. Alternatively, generally, it can also be a thermoplastic elastomer. In another alternative, the second component is composed of silicone, such as a two-component silicone, which hardens in an injection molding apparatus.

[0037] In one aspect of the invention, the delivery device is an input pump in the style of the aforementioned Ypsopump. Alternatively, the input pump can be a modular pump, which for example consists of reusable modules and disposable modules having electronics and drivers. Then, for example, a drug reservoir and, advantageously, an energy source can then be arranged in the disposable module. In a further alternative, the input pump can be a so-called plaster or patch pump, which is applied to the user's skin; in particular, it can be a modular patch pump.

[0038] In one aspect of the invention, the dispensing device is a syringe. The syringe may be, in particular, pin-shaped or pen-shaped. Alternatively, the syringe may be a so-called patch syringe, which can be adhered to the user's skin for a single injection of medication. In another alternative, the syringe may be a pin-shaped autoinjector, such as the one marketed by the applicant as Ypsomate. In yet another alternative, the syringe is an injection pen, by which multiple doses can be automatically dispensed, such as the applicant's known ServoPen. Exemplarily, the syringe may include electronic equipment that must be protected. Attached Figure Description

[0039] Figures 1 to 3 The prior art, as previously known, is illustrated based on the explanation of the background. Figures 4 and 5 show details for different forms of equal thickness. Figures 6 to 10 illustrate embodiments according to the invention. Figure 11 Alternative design options are shown.

[0040] Preferred embodiments of the invention will be described below in conjunction with the other accompanying drawings. This is intended to illustrate the basic feasible solutions of the invention and is in no way intended to be limiting.

[0041] Figure 1 Existing technology is shown: Ypsopump;

[0042] Figure 2 Existing technology is shown: a longitudinal section through a Ypsopump with a seal;

[0043] Figure 3 The prior art is shown: a drive unit with a piston rod and a seal;

[0044] Figure 4a -d indicates the Lurlo triangle and the rounded Lurlo triangle;

[0045] Figure 5a -d indicates the pentagon of equal thickness and its construction;

[0046] Figure 6a A perspective view of the input pump (modular input pump) according to the present invention is shown;

[0047] Figure 6b A pump module for an input pump according to the present invention is shown;

[0048] Figure 6c A storage module of an input pump according to the invention is shown, wherein a plaster or adhesive patch is not shown;

[0049] Figure 7a A pump module of an input pump with a driven piston rod according to the present invention is shown, wherein the cross-section of the piston rod corresponds to a uniform thickness shape with rounded corners;

[0050] Figure 7b The end element of the pump module is shown, along with the outer side of the end element;

[0051] Figure 7c The end element of the pump module is shown, along with the inside of the end element;

[0052] Figure 8a The end element (pull-back position) of the pump module with the inserted piston rod is shown.

[0053] Figure 8b Showing through in Figure 8a The vertical cross-section of the inserted piston rod and end element in the specified state;

[0054] Figure 9a The end element (outgoing position) of a pump module with an inserted piston rod is shown.

[0055] Figure 9b Showing through in Figure 9a The vertical cross-section of the inserted piston rod and end element in the specified state;

[0056] Figure 10a The end element of a pump module with an inserted piston rod is shown: a two-component injection-molded part;

[0057] Figure 10b This shows a two-component injection-molded part consisting only of the hard component (preform).

[0058] Figure 10c This shows the sealing component only in a two-component injection-molded part;

[0059] Figure 10d Shown through the reset button area from Figure 10a The vertical cross-section of the end element;

[0060] Figure 10e Showing the area through which electrical plug-in connections are made. Figure 10a The vertical cross-section of the end element;

[0061] Figure 11 Alternative implementations of the terminal element are shown. Detailed Implementation

[0062] Figure 6a A dispensing device according to the invention, in the form of a plaster pump or patch pump 1, is shown. The patch pump 1 has a very similar construction to that described in European Patent Application EP20181599.0, which is incorporated herein by reference in its entirety. Detailed information regarding the basic technology of the patch pump 1 can be directly and explicitly obtained from application EP20181599.0.

[0063] like Figure 6b and 6c As shown, the patch pump 1 is modularly constructed and includes a pump module 2 and a storage module 3, which are detachably connected to each other via a bayonet joint using a component 10 at the storage module 3 and a component 11 at the pump module. When the storage module 3 and the pump module 2 are connected via the bayonet joint, a locking spring 11a of the pump module 2 engages behind a locking protrusion 10a of the storage module 3, thus preventing the two modules from unintentionally detaching from each other. The pump module 2 is reusable and includes pump electronics (not shown) and a driver (not shown, having a motor, gearbox, and transmission elements), as well as a piston rod 30 movably supported within the pump module 2. The pump module 2 may further include a power source in the form of a rechargeable battery.

[0064] The reservoir module 3 includes a reservoir, an energy source (e.g., a battery), and an inlet line that guides the drug to be administered from the reservoir into the tissue. When the reservoir module 3 and pump module 2 are assembled, the battery can be used to charge a rechargeable battery (or a similar energy storage device, such as a capacitor). The reservoir (not shown) typically has a roughly capillary shape, with a movable plunger (not shown) supported within it. The volume in the reservoir can be decreased or increased by moving the plunger. When the pump module 2 and reservoir module 3 are assembled, the plunger in the reservoir can be moved by axially moving a piston rod. In this case, typically the piston rod 30 moves into the reservoir module 3, and subsequently the volume in the reservoir decreases, and finally the drug is infused into the tissue of the user through the inlet line.

[0065] As described, the piston rod 30 is movable, particularly partially movable, out of the pump module 2. The pump module 2 includes a housing 12 and an end element 20. Various components are arranged at the end element 20, for example in... Figure 6b and 7aAs can be seen, these are the bayonet connector 11 (a component of the pump module, arranged around the through-hole 21 in a pipe-like form), the through-hole 21 for the piston rod 30, the plug (or connector, i.e., Stecker) 23 for electrical connection, and the reset button 24—other or additional components are possible. The end components have a front side 20a and a rear side 20b, see [reference needed]. Figure 7b and 7c .

[0066] The piston rod 30 is guided in the through portion 21, see [reference]. Figures 7a to 7c According to the invention, the piston rod 30 has a cross-section corresponding to a triangle with rounded corners and equal thickness. The through-hole 21 has a shape that roughly corresponds to the equal thickness of the female mold, such that the piston rod 30 can be pushed through the through-hole 21 but cannot rotate about the axis of the piston rod 30. The piston rod 30 is thus movable but torsionally fixedly supported in the through-hole 21. The through-hole 21 is reinforced here by ribs 21a, wherein the ribs 21a and their end faces 21b can also guide the piston rod 30 (see in particular). Figures 8a to 9b To protect the interior of the pump module from liquid, a seal 22 is arranged on the front side 20a of the end element 20. The seal 22 replicates the uniform thickness shape of the cross-section of the piston rod 30. In its undeformed state, the opening of the seal 22 is smaller than the cross-section of the piston rod 30. If the piston rod 30 is pushed through the opening of the seal 22, the opening expands. Therefore, the seal is made of a deformable material, particularly an elastomer. The seal thus prevents liquid from penetrating the interface between the piston rod 30 and the seal 22 (and therefore the through-hole 21). The seal 22 can be self-adhesive to the connector 11. However, in this embodiment, the end element 20 is a two-component injection-molded part, which allows the walls of the end element 20 and the seal 22 to be manufactured as a single component with a tight adhesive bond. Figure 10b and 10c As shown, the end element 20 consists of a component 26 called an end element plate 26 and a sealing assembly 25. To better understand the end element 20, the end element 20 is... Figure 10b and 10c The assembly is divided into its components. The sealing assembly is made of a softer material (especially an elastomer) than the end element plate 26, which must guide the piston rod 30. For this purpose, the end element plate 26 must have a certain rigidity and strength. In manufacturing, the end element plate is first injected, and then the sealing assembly 25 is injected, into the same injection mold.

[0067] like Figure 10cAs can be seen, the sealing assembly 25 includes not only the seal 22, but also a seal 24 for the reset button. The actual reset switch is not shown in this figure; it is used to reset the settings in the pump electronics of the pump module 2, delete the corresponding memory, and / or restart the electronics of the pump module 2 (e.g., by a brief electrical disconnect). Figure 10d The image shows a vertical cross-section through the end element 20 in the reset button area, particularly the seal 24. The seal is a structured diaphragm in which the operating element 24a of the seal 24 does not protrude from the surrounding wall of the end element 20 in the direction of the front side 20a, but is flat or recessed to prevent accidental operation of the reset button. To securely retain (or improve attachment) the seal 24 in the end element 20, retaining element 20d (see [reference]) is used. Figure 10b and 10d A chemical bond is advantageously present at the transition between the end element 20 and the seal 24 at the end element. When the seal 24 is cast onto the end element plate 26, an engagement portion is also created between the end element 20 and the seal 24.

[0068] The sealing assembly 26 also includes a seal 28 for the electrical contacts of the electrical connector 23. In the illustrated embodiment, the seal 28 has a geometrically smaller size compared to the pin-constructed contacts, thus the radial pressure of the seal is generated on the pin. This is intended to prevent liquid from intruding into the interior of the pump module 2 along the electrical contacts. Figure 10e A vertical cross-section of the end element 20 is shown in the region through the plug connector 23, with the front side of the end element 20 on the right in the figure.

[0069] To avoid the need for all described seals to be individually injection molded during the manufacture of the end element, the seals are interconnected via arms 25a, 25b, and 25b. A corresponding channel is provided at the rear side (26) of the end element plate. In this embodiment, all seals are injection molded through orifices 25d. In this way, the end plate 20 with seals can be cleverly manufactured in a single injection molding process.

[0070] Figure 11 An alternative design for end element 20 is shown, namely, end element 20' with a modified seal 22'. In this seal 22', the opening is circular and the uniform thickness shape of the piston rod 30 is not reproduced. However, the sealing function of the seal 22 is feasible because the uniform thickness shape precisely allows for a more uniform stress distribution in the seal, thus avoiding, for example, excessive stress differences in the corner regions relative to the edges, as would occur in the case of, for example, an equilateral triangle as the cross-section of the piston rod. However, as described, the uniform thickness shape allows for reliable torsional resistance.

[0071] List of reference numerals

[0072] Existing technology:

[0073] p1 Ypsopump

[0074] p2 Capel

[0075] p3 diaphragm

[0076] p4 plunger

[0077] p5 casing

[0078] p6 Observation Window

[0079] p7 battery cover

[0080] p9 Capu Earrings

[0081] p10 (Operation) Button

[0082] p20 Touchscreen Display

[0083] p30 Input Adapter

[0084] p30a intubation

[0085] p31 Input Pipe

[0086] p40 motor

[0087] P45 transmission

[0088] p50 drive housing

[0089] p50a Torsion-resistant section

[0090] p51 drive sleeve

[0091] p52 Piston Rod

[0092] p52a guide slot

[0093] p53 Flange

[0094] p54 Seal (O-ring)

[0095] p60 support plate

[0096] p60a seal

[0097] p90 battery

[0098] p91 battery box

[0099] p92 Positive battery contact / connection part

[0100] p92a seal

[0101] p93 Negative battery contact / connection section

[0102] p93a seal

[0103] Equal thickness shape - diagram:

[0104] r1 Lurlo triangle (the simplest nontrivial isothickness shape)

[0105] R thickness

[0106] The r2 equilateral triangle serves as the basis for constructing the Luró triangle.

[0107] r3 is used to construct a widened arc of equal thickness with rounded corners.

[0108] r4 is the angular radius (|r4| corresponds to the size of the radius).

[0109] R' thickness (R'=R+2*|r4|)

[0110] r5 is a uniform thickness shape with rounded corners.

[0111] r10 is a pentagonal, uniformly thick shape.

[0112] r11 Constructing a Pentagon

[0113] r12 A pentagonal arc of equal thickness

[0114] R2 thickness

[0115] Feeding device:

[0116] 1. A feeding device in the form of a modular patch pump

[0117] 2 (Reusable) Pump Modules

[0118] 3 Storage Module

[0119] 10-bayonet connector (part of storage module 3)

[0120] 10a Locking protrusion

[0121] 11. Bayonet connector (part of pump module 2)

[0122] 11a Locking Spring

[0123] 12. Pump module housing

[0124] The end element of pump module 2 is implemented as a two-component injection molded part.

[0125] 20' Alternative End Components

[0126] 20a Front side of terminal element 20

[0127] 20b terminal element 20 rear side

[0128] 20c end face

[0129] 20d holding element

[0130] 21 Pass-through part

[0131] 21a Rib

[0132] 21b end face

[0133] 22. Piston rod seal

[0134] 22' Alternative piston rod seal

[0135] 22a Sealing surface

[0136] 23 Electrically pluggable connecting elements having electrical contacts

[0137] 24. Reset button seal (actual reset button not shown)

[0138] 24a Operating element

[0139] 25 Sealing assembly (sealing component of end element 20)

[0140] 25a Sealing connection for seal 28 used in electrical contacts

[0141] 25b Sealing connection for seal 22 used for piston rod 30

[0142] 25c Sealing connection for seal 24 used for reset button

[0143] 25d eyelet

[0144] 26-terminal component board (carrier component of terminal component 20)

[0145] 28 Seals for electrical contact portion 23

[0146] 30. A piston rod with a cross-sectional shape of uniform thickness.

Claims

1. A delivery device for administering a fluid drug, comprising at least: a. shell, b. A reservoir with variable internal volume for storing a fluid drug, wherein the reservoir is at least partially arranged within a housing. c. A drive mechanism, wherein the drive mechanism is at least partially disposed within the housing and comprises at least […]. i. Driver ii. A piston rod movably supported in the housing, which can be moved by the actuator, and wherein the variable internal volume can be changed by the movement. in, The piston rod can be guided through the through-hole to pass through the inner wall of the housing and / or the outer wall of the housing module. The piston rod is movably but non-rotatably supported in the through portion. The support portion between the piston rod and the through-hole includes an elastically deformable seal that prevents liquid from passing through the through-hole but allows movement of the piston rod. Its features The periphery of the piston rod cross-section exhibits an approximately nontrivial isothickness shape.

2. The feeding device according to claim 1, wherein, The housing is modularly constructed, and the modules of the housing can be detachably connected to each other.

3. The feeding device according to claim 1, wherein, The storage unit is at least partially arranged in the storage module of the housing.

4. The feeding device according to claim 1, wherein, The drive unit is at least partially arranged in the drive module of the housing.

5. The feeding device according to claim 1, wherein, The actuator is a motor or a spring.

6. The feeding device according to any one of claims 1 to 5, wherein, The equal thickness shape is an equal thickness shape with three or more corners.

7. The feeding device according to claim 6, wherein, The equal thickness shape is a shape with 5 or 7 corners.

8. The feeding device according to any one of claims 1 to 5, wherein, The equal thickness shape is an equal thickness shape with rounded corners.

9. The feeding device according to any one of claims 1 to 5, wherein, The housing is modular and consists of a storage module housing and a drive module housing, which can be detachably connected to each other. The drive module housing is made of plastic and has a wall region with through-holes that is a two-component injection molded part, wherein the material of the first component is used for the wall and the material of the second component is used for the seal.

10. The feeding device according to claim 9, wherein, The material of the second component is thermoplastic elastomer (TPE).

11. The feeding device according to claim 10, wherein, The material of the second component is thermoplastic polyurethane or thermoplastic polyamide.

12. The feeding device according to claim 9, wherein, The material of the second component is silicone.

13. The feeding device of claim 9, wherein the region of the wall having the through portion has at least one additional through portion, the through portion including at least one additional seal, wherein the at least one additional seal is also part of the two-component injection molded component.

14. The feeding device according to claim 12, wherein, The at least one additional through-hole is a through-hole for operating elements and / or one or more electrical contacts.

15. The feeding device according to any one of claims 1 to 5, characterized in that, The feeding device is an input pump.

16. The feeding device according to claim 15, characterized in that, The input pump is a plaster pump or patch pump.

17. The feeding device according to any one of claims 1 to 5, characterized in that, The delivery device is a syringe.

18. The feeding device according to claim 17, characterized in that, The delivery device is a pin-shaped injection device.

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