A kind of weak piglet nutritional feed additive and its preparation method and application

Abstract

The present invention provides a nutritional feed additive for weak piglets, a preparation method and an application thereof, and belongs to the field of feed additives, and specifically relates to a nutritional feed additive for weak piglets, a preparation method and an application thereof. The nutritional feed additive for weak piglets is made of medium-chain triglycerides, bovine colostrum powder, specific yolk antibodies, lactic acid, citric acid, glutamine, sodium dimethylglycinate, glucose, astragalus polysaccharide, calcium dihydrogen phosphate, complex trace elements, complex vitamins, and whey powder. The nutritional feed additive for weak piglets has the characteristics of rapid energy supply, comprehensive nutritional value, safety and high efficiency, and can effectively treat weak piglets with a birth weight of less than 1 kg.

Description

Technical Field

[0001] The invention belongs to the field of feed additives, and in particular relates to a nutritional feed additive for weak piglets and a preparation method and application thereof. Background Art

[0002] In large-scale pig farms, methods such as increasing the intensity of sow utilization, increasing the number of piglets per litter, and shortening the time from weaning to re-breeding are often used to increase the annual productivity of sows and thus improve the economic benefits of the pig farm. While pursuing the reproductive efficiency of sows, it often brings about the problem of more weak piglets. Weak piglets refer to piglets with a birth weight of less than 1kg, and weak piglets usually account for about 10%-20% of the total number of newborn piglets. The causes of weak piglets can be attributed to the following aspects: First, the sow has too many piglets, the newborn piglets have low weight and weak vitality; second, the sow has a high parity, and some piglets are malnourished during the embryonic period; third, the sow has dystocia, too long labor, etc., resulting in weak physical constitution of piglets after birth; fourth, the sow is infected with diseases during pregnancy. These weak piglets are usually underdeveloped, weak in physique, and eat less colostrum. They often die due to a combination of hunger, cold, squeezing, disease infection, etc. According to statistics, the death of piglets after birth mainly occurs in the first week, accounting for 60% of the total number of deaths. Among them, insufficient energy intake is one of the most important reasons for piglet death. The digestive system of piglets is not fully developed, and the digestion and utilization rate of exogenous fat is low, which cannot meet the energy and fatty acid nutrition needs of piglets in special physiological stages. At present, in actual production, there is no rescue plan for weak newborn piglets, and most of them are eliminated. Moreover, even if weak piglets survive the first week after birth, their growth performance will be poor in the later stage, resulting in a low survival rate.

[0003] The week before piglets are born is a critical period for their survival. Eating colostrum as soon as possible is crucial for their survival. For weak piglets with poor physique, they have poor vitality, insufficient energy supply for movement, and find it difficult to eat colostrum or eat less colostrum, which can easily increase the mortality rate of piglets. In response to the health problems of suckling piglets, some feed companies have developed milk replacers to replace regular milk, but these products are mainly suitable for piglets one week after birth. And these products have some disadvantages, such as the quality of the milk powder used is not up to standard, the quality of the milk protein, immunoglobulin, lactose, milk fat and other ingredients contained are poor, and their efficacy is far from meeting the needs of piglets, and these products cannot achieve the effect of sow colostrum. Summary of the invention

[0004] In order to solve the above technical problems, the purpose of the present invention is to provide a nutritional feed additive for weak piglets. As a nutritional energy supplement outside colostrum, the nutritional feed additive can quickly provide energy to piglets, so that weak piglets can recover and eat colostrum as soon as possible, thereby improving the survival rate and growth rate of weak piglets and improving the uniformity of the whole group of piglets.

[0005] A nutritional feed additive for weak piglets is prepared from medium-chain triglycerides, bovine colostrum powder, specific egg yolk antibodies, lactic acid, citric acid, glutamine, sodium dimethylglycinate, glucose, astragalus polysaccharide, monocalcium phosphate, complex trace elements, complex vitamins and whey powder.

[0006] Furthermore, the weak piglet nutritional feed additive is made of 300-500 parts of medium-chain triglycerides, 150-350 parts of bovine colostrum powder, 3-7 parts of specific yolk antibodies, 1-3 parts of lactic acid, 1-3 parts of citric acid, 10-14 parts of glutamine, 3-7 parts of sodium dimethylglycinate, 80-120 parts of glucose, 3-7 parts of astragalus polysaccharide, 10-14 parts of monocalcium phosphate, 3-7 parts of complex trace elements, 1-3 parts of complex vitamins, and 100-300 parts of whey powder, measured by weight.

[0007] Furthermore, the weak piglet nutritional feed additive is made of 350-450 parts of medium-chain triglycerides, 200-300 parts of bovine colostrum powder, 4-6 parts of specific egg yolk antibodies, 1.5-2.5 parts of lactic acid, 1.5-2.5 parts of citric acid, 11-13 parts of glutamine, 4-6 parts of sodium dimethylglycinate, 90-110 parts of glucose, 4-6 parts of astragalus polysaccharide, 11-13 parts of monocalcium phosphate, 4-6 parts of complex trace elements, 1.5-2.5 parts of complex vitamins, and 150-250 parts of whey powder, measured by weight.

[0008] Furthermore, the weak piglet nutritional feed additive is made of 400 parts of medium-chain triglycerides, 250 parts of bovine colostrum powder, 5 parts of specific yolk antibodies, 2 parts of lactic acid, 2 parts of citric acid, 12 parts of glutamine, 5 parts of sodium dimethylglycinate, 100 parts of glucose, 5 parts of astragalus polysaccharide, 12 parts of monocalcium phosphate, 5 parts of complex trace elements, 2 parts of complex vitamins, and 200 parts of whey powder, measured by weight.

[0009] Among them, the above-mentioned trace elements are made of yeast selenium, porphyrin iron, and zinc glycinate, and the complex vitamins are made of vitamin A, vitamin D3, vitamin E, and vitamin K.

[0010] Furthermore, the composite trace element is prepared by yeast selenium, porphyrin iron, and glycinate zinc in a weight ratio of (2-4):(4-6):(1-3) in parts by weight.

[0011] Furthermore, the composite trace element is prepared by yeast selenium, porphyrin iron, and glycinate zinc in a weight ratio of (2.5-3.5):(4.5-5.5):(1.5-2.5) in parts by weight.

[0012] Preferably, the composite trace element is made of yeast selenium, porphyrin iron and glycinate zinc in a weight ratio of 3:5:2.

[0013] Furthermore, the vitamin complex is made of vitamin A, vitamin D3, vitamin E and vitamin K in a weight ratio of (13-17):(2-6):(65-85):(4-8) in parts by weight.

[0014] Preferably, the vitamin complex is made of vitamin A, vitamin D3, vitamin E and vitamin K in a weight ratio of (14-16):(3-5):(70-80):(5-7) by weight.

[0015] More preferably, the vitamin complex is made of vitamin A, vitamin D3, vitamin E and vitamin K in a weight ratio of 15:4:75:6.

[0016] The present invention also provides a method for preparing the nutritional feed additive for weak piglets, comprising the following steps:

[0017] (1) Weighing yeast selenium, porphyrin iron, and glycinate zinc according to a weight ratio and mixing them evenly to prepare a composite trace element;

[0018] (2) Weighing vitamin A, vitamin D3, vitamin E, and vitamin K according to weight ratio and mixing them evenly to prepare a vitamin complex;

[0019] (3) weighing medium chain triglycerides, bovine colostrum powder, specific egg yolk antibody, lactic acid, citric acid, glutamine, sodium dimethylglycinate, glucose, astragalus polysaccharide, calcium dihydrogen phosphate, and whey powder according to the total weight ratio, and then mixing them with the composite trace elements and the composite vitamins to prepare a premix, thereby obtaining a powder;

[0020] (4) The premix and softened water are mixed uniformly at a mass volume ratio (w / v) of 1:(0.2-2) to obtain a paste.

[0021] The present invention also provides the use of the weak piglet nutritional feed additive in preparing an oral preparation for treating weak piglets.

[0022] Specifically, the weak piglet nutritional feed additive of the present invention is prepared into an oral preparation and applied to weak piglets born 1-3 days old, wherein the weak piglets are piglets with a birth weight of less than 1.0 kg; the feeding method is to administer 2 mL of the weak piglet nutritional feed additive oral preparation each time, once a day, for 3 consecutive days, and the best effect is achieved within 4 hours after the piglet is born.

[0023] The advantages and beneficial effects of the nutritional feed additive for treating weak piglets of the present invention are:

[0024] (1) The product of the present invention can provide energy to weak piglets quickly and directly, quickly replenish nutritional energy, and reduce the death of weak piglets caused by insufficient energy and low body temperature.

[0025] (2) The product of the present invention directly targets the problems of poor physique and weak vitality of weak piglets at birth. It has comprehensive nutritional value and can increase the level of growth-promoting hormones and immunoglobulin content in weak piglets, increase their survival rate, improve their growth performance, reduce the diarrhea rate, and restore them to or close to the level of normal healthy piglets. In addition, the proportion of weak piglets that can be cured using this product is over 85%.

[0026] (3) The product of the present invention quickly supplements vitamin A, vitamin D3, vitamin E, vitamin K and trace elements such as iron and selenium, and utilizes them comprehensively and efficiently to meet the needs of growth and development and improve the immunity of weak piglets.

[0027] (4) The product of the present invention has many advantages such as safety, stability, high efficiency, simple preparation process and low production cost. DETAILED DESCRIPTION

[0028] The following examples are used to illustrate the present invention but are not intended to limit the scope of the present invention.

[0029] Example 1

[0030] (1) Weigh 3 parts of yeast selenium, 5 parts of porphyrin iron, and 2 parts of glycinate zinc according to weight ratio to prepare composite trace elements;

[0031] (2) Weigh 15 parts of vitamin A, 34 parts of vitamin D, 75 parts of vitamin E, and 6 parts of vitamin K according to weight ratio to prepare a vitamin complex;

[0032] (3) Weigh 400 parts of medium chain triglycerides, 250 parts of bovine colostrum powder, 5 parts of specific egg yolk antibodies, 2 parts of lactic acid, 2 parts of citric acid, 12 parts of glutamine, 5 parts of sodium dimethylglycinate, 100 parts of glucose, 5 parts of astragalus polysaccharide, 12 parts of monocalcium phosphate, 200 parts of whey powder, 5 parts of the above-mentioned complex trace elements, and 2 parts of the above-mentioned complex vitamins according to the total weight ratio, and mix them evenly to prepare a premix;

[0033] (4) The premix and softened water are mixed thoroughly at a mass volume ratio (w / v) of 1:0.5 to obtain a paste.

[0034] Example 2

[0035] (1) Weighing 2 parts of yeast selenium, 4 parts of porphyrin iron, and 1 part of glycinate zinc according to weight ratio to prepare composite trace elements;

[0036] (2) Weigh 13 parts of vitamin A, 32 parts of vitamin D, 65 parts of vitamin E, and 4 parts of vitamin K according to weight ratio to prepare a vitamin complex;

[0037] (3) Weigh 300 parts of medium chain triglycerides, 350 parts of bovine colostrum powder, 3 parts of specific egg yolk antibodies, 1 part of lactic acid, 3 parts of citric acid, 10 parts of glutamine, 7 parts of sodium dimethylglycinate, 80 parts of glucose, 7 parts of astragalus, 10 parts of calcium dihydrogen phosphate, 200 parts of whey powder, 7 parts of the above-mentioned complex trace elements, and 1 part of the above-mentioned complex vitamins according to the total weight ratio, and mix them evenly to prepare a premix;

[0038] (4) The premix and softened water are mixed thoroughly at a mass volume ratio (w / v) of 1:0.5 to obtain a paste.

[0039] Example 3

[0040] (1) Weigh 4 parts of yeast selenium, 6 parts of porphyrin iron, and 3 parts of glycinate zinc according to weight ratio to prepare composite trace elements;

[0041] (2) Weigh 17 parts of vitamin A, 36 parts of vitamin D, 85 parts of vitamin E, and 8 parts of vitamin K according to weight ratio to prepare a vitamin complex;

[0042] (3) Weigh 500 parts of medium chain triglycerides, 150 parts of bovine colostrum powder, 7 parts of specific egg yolk antibodies, 3 parts of lactic acid, 1 part of citric acid, 14 parts of glutamine, 3 parts of sodium dimethylglycinate, 120 parts of glucose, 3 parts of astragalus polysaccharide, 14 parts of monocalcium phosphate, 200 parts of whey powder, 3 parts of the above-mentioned complex trace elements, and 3 parts of the above-mentioned complex multivitamins according to the total weight ratio, and mix them evenly to prepare a premix;

[0043] (4) The premix and softened water are mixed thoroughly at a mass volume ratio (w / v) of 1:0.5 to obtain a paste.

[0044] Example 4

[0045] (1) Weighing 2.5 parts of yeast selenium, 5.5 parts of porphyrin iron, and 1.5 parts of glycinate zinc according to weight ratio to prepare a composite trace element;

[0046] (2) Weigh 14 parts of vitamin A, 35 parts of vitamin D, 70 parts of vitamin E, and 5 parts of vitamin K according to weight ratio to prepare a vitamin complex;

[0047] (3) Weigh 500 parts of medium chain triglycerides, 200 parts of bovine colostrum powder, 5 parts of specific egg yolk antibodies, 3 parts of lactic acid, 1 part of citric acid, 14 parts of glutamine, 3 parts of sodium dimethylglycinate, 120 parts of glucose, 3 parts of astragalus polysaccharide, 14 parts of calcium dihydrogen phosphate, 200 parts of whey powder, 3 parts of the above-mentioned complex trace elements, and 3 parts of the above-mentioned complex vitamins according to the total weight ratio, and mix them evenly to prepare a premix;

[0048] (4) The premix and softened water are mixed thoroughly at a mass volume ratio (w / v) of 1:0.2 to obtain a paste.

[0049] Example 5

[0050] (1) Weighing 3.5 parts of yeast selenium, 4.5 parts of porphyrin iron, and 1.5 parts of glycinate zinc according to a weight ratio to prepare a composite trace element;

[0051] (2) Weigh 16 parts of vitamin A, 33 parts of vitamin D, 80 parts of vitamin E, and 5 parts of vitamin K according to weight ratio to prepare a vitamin complex;

[0052] (3) Weigh 350 parts of medium chain triglycerides, 200 parts of bovine colostrum powder, 4 parts of specific egg yolk antibodies, 1.5 parts of lactic acid, 1.5 parts of citric acid, 11 parts of glutamine, 4 parts of sodium dimethylglycinate, 90 parts of glucose, 4 parts of astragalus polysaccharide, 11 parts of monocalcium phosphate, 250 parts of whey powder, 4 parts of the above-mentioned complex trace elements, and 1.5 parts of the above-mentioned complex vitamins according to the total weight ratio, and mix them evenly to prepare a premix;

[0053] (4) The premix and softened water are mixed thoroughly at a mass volume ratio (w / v) of 1:1 to obtain a paste.

[0054] Example 6

[0055] (1) Weigh 3 parts of yeast selenium, 5 parts of porphyrin iron, and 2 parts of glycinate zinc according to weight ratio to prepare composite trace elements;

[0056] (2) Weighing 15 parts of vitamin A, 33 parts of vitamin D, 75 parts of vitamin E, and 5 parts of vitamin K according to weight ratio to prepare a vitamin complex;

[0057] (3) Weigh 450 parts of medium chain triglycerides, 300 parts of bovine colostrum powder, 6 parts of specific egg yolk antibodies, 2.5 parts of lactic acid, 2.5 parts of citric acid, 13 parts of glutamine, 6 parts of sodium dimethylglycinate, 110 parts of glucose, 6 parts of astragalus polysaccharide, 13 parts of monocalcium phosphate, 150 parts of whey powder, 6 parts of the above-mentioned complex trace elements, and 2.5 parts of the above-mentioned complex vitamins according to the total weight ratio, and mix them evenly to prepare a premix;

[0058] (4) The premix and softened water are mixed thoroughly at a mass volume ratio (w / v) of 1:0.4 to obtain a paste.

[0059] Comparative Example 1

[0060] Compared with Example 1, medium chain triglyceride is not contained and replaced by coconut oil. Other operations are the same as those in Example 1.

[0061] The specific preparation method is as follows:

[0062] (1) Weigh 3 parts of yeast selenium, 5 parts of porphyrin iron, and 2 parts of glycinate zinc according to weight ratio to prepare composite trace elements;

[0063] (2) Weigh 15 parts of vitamin A, 34 parts of vitamin D, 75 parts of vitamin E, and 6 parts of vitamin K according to weight ratio to prepare a vitamin complex;

[0064] (3) Weigh 400 parts of coconut oil, 250 parts of bovine colostrum powder, 5 parts of specific egg yolk antibody, 2 parts of lactic acid, 2 parts of citric acid, 12 parts of glutamine, 5 parts of sodium dimethylglycinate, 100 parts of glucose, 5 parts of astragalus polysaccharide, 12 parts of monocalcium phosphate, 200 parts of whey powder, 5 parts of the above-mentioned complex trace elements, and 2 parts of the above-mentioned complex vitamins according to the total weight ratio, and mix them evenly to prepare a premix;

[0065] (4) The premix and softened water are mixed thoroughly at a mass volume ratio (w / v) of 1:0.5 to obtain a paste.

[0066] Comparative Example 2

[0067] Compared with Example 1, the colostrum powder is not contained and is replaced by whole milk powder. Other operations are the same as those in Example 1.

[0068] The specific preparation method is as follows:

[0069] (1) Weigh 3 parts of yeast selenium, 5 parts of porphyrin iron, and 2 parts of glycinate zinc according to weight ratio to prepare composite trace elements;

[0070] (2) Weigh 15 parts of vitamin A, 34 parts of vitamin D, 75 parts of vitamin E, and 6 parts of vitamin K according to weight ratio to prepare a vitamin complex;

[0071] (3) Weigh 400 parts of medium chain triglycerides, 250 parts of whole milk powder, 5 parts of specific egg yolk antibodies, 2 parts of lactic acid, 2 parts of citric acid, 12 parts of glutamine, 5 parts of sodium dimethylglycinate, 100 parts of glucose, 5 parts of astragalus polysaccharide, 12 parts of calcium dihydrogen phosphate, 200 parts of whey powder, 5 parts of the above-mentioned complex trace elements, and 2 parts of the above-mentioned complex vitamins according to the total weight ratio, and mix them evenly to prepare a premix;

[0072] (4) The premix and softened water are mixed thoroughly at a mass volume ratio (w / v) of 1:0.5 to obtain a paste.

[0073] Comparative Example 3

[0074] Compared with Example 1, the specific egg yolk antibody is not contained and is replaced by egg yolk powder. Other operations are the same as those in Example 1.

[0075] The specific preparation method is as follows:

[0076] (1) Weigh 3 parts of yeast selenium, 5 parts of porphyrin iron, and 2 parts of glycinate zinc according to weight ratio to prepare composite trace elements;

[0077] (2) Weigh 15 parts of vitamin A, 34 parts of vitamin D, 75 parts of vitamin E, and 6 parts of vitamin K according to weight ratio to prepare a vitamin complex;

[0078] (3) Weigh 400 parts of medium chain triglycerides, 250 parts of bovine colostrum powder, 5 parts of egg yolk powder, 2 parts of lactic acid, 2 parts of citric acid, 12 parts of glutamine, 5 parts of sodium dimethylglycinate, 100 parts of glucose, 5 parts of astragalus polysaccharide, 12 parts of monocalcium phosphate, 200 parts of whey powder, 5 parts of the above-mentioned complex trace elements, and 2 parts of the above-mentioned complex vitamins according to the total weight ratio, and mix them evenly to prepare a premix;

[0079] (4) The premix and softened water are mixed thoroughly at a mass volume ratio (w / v) of 1:0.5 to obtain a paste.

[0080] Comparative Example 4

[0081] Compared with Example 1, sodium dimethylglycinate is not contained, and other operations are the same as those of Example 1.

[0082] The specific preparation method is as follows:

[0083] (1) Weigh 3 parts of yeast selenium, 5 parts of porphyrin iron, and 2 parts of glycinate zinc according to weight ratio to prepare composite trace elements;

[0084] (2) Weigh 15 parts of vitamin A, 34 parts of vitamin D, 75 parts of vitamin E, and 6 parts of vitamin K according to weight ratio to prepare a vitamin complex;

[0085] (3) Weigh 400 parts of medium chain triglycerides, 250 parts of bovine colostrum powder, 5 parts of specific egg yolk antibodies, 2 parts of lactic acid, 2 parts of citric acid, 12 parts of glutamine, 100 parts of glucose, 5 parts of astragalus polysaccharide, 12 parts of calcium dihydrogen phosphate, 200 parts of whey powder, 5 parts of the above-mentioned complex trace elements, and 2 parts of the above-mentioned complex vitamins according to the total weight ratio, and mix them evenly to prepare a premix;

[0086] (4) The premix and softened water are mixed thoroughly at a mass volume ratio (w / v) of 1:0.5 to obtain a paste.

[0087] Comparative Example 5

[0088] Compared with Example 1, medium-chain triglycerides, bovine colostrum powder and specific egg yolk antibodies are not contained and are replaced by coconut oil, whole milk powder and egg yolk powder respectively. Other operations are the same as those in Example 1.

[0089] The specific preparation method is as follows:

[0090] (1) Weigh 3 parts of yeast selenium, 5 parts of porphyrin iron, and 2 parts of glycinate zinc according to weight ratio to prepare composite trace elements;

[0091] (2) Weigh 15 parts of vitamin A, 34 parts of vitamin D, 75 parts of vitamin E, and 6 parts of vitamin K according to weight ratio to prepare a vitamin complex;

[0092] (3) Weigh 400 parts of coconut oil, 250 parts of whole milk powder, 5 parts of egg yolk powder, 2 parts of lactic acid, 2 parts of citric acid, 12 parts of glutamine, 5 parts of sodium dimethylglycinate, 100 parts of glucose, 12 parts of monocalcium phosphate, 200 parts of whey powder, 5 parts of the above-mentioned complex trace elements, and 2 parts of the above-mentioned complex vitamins according to the total weight ratio, and mix them evenly to prepare a premix;

[0093] (4) The premix and softened water are mixed thoroughly at a mass volume ratio (w / v) of 1:0.5 to obtain a paste.

[0094] Test Example 1

[0095] 1.1 Test materials

[0096] Nutrient feed additives and glucose for weak piglets prepared in Examples 1 to 6.

[0097] 1.2 Experimental animals and groups

[0098] A total of 210 weak piglets of Durbin × Chang × Da from sows with similar parity and birth weight less than 1 kg were randomly divided into 7 groups, 30 in each group, which were weak piglet control group and experimental group. In addition, 30 piglets with normal birth weight (about 1.3 kg) were selected as normal piglet control group.

[0099] The experimental group was gavaged with 2 mL of the weak piglet nutritional feed additive prepared by Examples 1 to 6 within 4 hours after the piglets were born, and then gavaged once a day, 2 mL each time, for 3 consecutive days.

[0100] The weak piglet control group and the normal piglet control group were gavaged with 2 mL of glucose within 4 hours after birth, and then gavaged once a day, 2 mL each time, for 3 consecutive days.

[0101] All piglets were supplemented with colostrum for the first 3 days, and fed with special milk powder for piglets from the 4th to the 21st day. They were weaned on the 21st day, and the number of surviving piglets weaned on the 21st day, weaning weight, and diarrhea incidence were recorded.

[0102] 1.3 Feeding and management

[0103] The feeding experiment was conducted at a Da Bei Nong experimental pig farm in Hebei Province. The pigs were equipped with mesh floor, infrared heat lamp, free sucking, automatic drinking fountain, and the environmental conditions of each pen were the same. Routine immunization and feeding management were followed.

[0104] 1.4 Test preparation and methods

[0105] Piglet growth performance indicators: average birth weight of piglets, average weight of weaned piglets, average daily weight gain, weaning survival rate, diarrhea rate, serum hormone levels and immunoglobulin content of 7-day-old piglets.

[0106] 1.5 Results and Analysis

[0107] Table 1 Effects of each group on piglet production performance

[0108]

[0109] The test results are shown in Table 1 and Table 2. As shown in Table 1, Example 1 to 6 groups can improve the weaning survival rate and average daily weight gain, and reduce the diarrhea rate of piglets. Although the average weight, weaning survival rate and diarrhea rate of the piglets in the Example 1-6 groups of the present invention at the end of the test are slightly lower than those of the normal piglet control group, their average daily weight gain is improved. Overall, the average rescue rate of weak piglets in the Example group can reach 87.78%, among which Example 1 has the best effect, which can reach 93.33%.

[0110] Table 2 Effects of each group on serum hormone levels and immunoglobulins in 7-day-old piglets

[0111]

[0112] As shown in Table 2, Example 1-6 groups were able to increase the levels of serum hormone insulin-like growth factor 1 (IGF-1) and growth hormone (GH) in 7-day-old piglets, and also significantly increased the contents of immunoglobulin G and immunoglobulin M.

[0113] Test Example 2

[0114] 2.1 Test materials

[0115] Nutritional feed additives for weak piglets prepared in Example 1 and Comparative Examples 1 to 5, and glucose.

[0116] 2.2 Experimental animals and groups

[0117] A total of 280 weak piglets of Durbin×Chang×Large were selected from sows with similar parity and birth weight less than 1kg. They were randomly divided into 7 groups, 40 in each group, which were control group and experimental group.

[0118] The experimental group was gavaged with 2 mL of the weak piglet nutritional feed additive prepared by Example 1 and Comparative Examples 1 to 5 within 4 hours after the piglets were born, and then gavaged once a day, 2 mL each time, for 3 consecutive days.

[0119] The control group was gavaged with 2 mL of glucose within 4 hours of piglet birth, and then once a day, 2 mL each time, for 3 consecutive days.

[0120] All piglets were supplemented with colostrum for the first 3 days, and fed with special milk powder for piglets from the 4th to the 21st day. They were weaned on the 21st day, and the number of surviving piglets weaned on the 21st day, weaning weight, and diarrhea incidence were recorded.

[0121] 2.3 Feeding and management

[0122] The feeding experiment was conducted in a pig farm in Shandong Province. The pigs were equipped with mesh floor, infrared heat lamp, free sucking, automatic drinking fountain, and the environmental conditions of each pen were the same. Routine immunization and feeding management were followed.

[0123] 2.4 Test preparation and methods

[0124] Piglet growth performance indicators: average birth weight of piglets, daily weight gain at 7 days of age, average weight of weaned piglets, average daily weight gain, survival rate at 7 days of age, weaning survival rate, diarrhea rate, serum hormone levels and immunoglobulin content of piglets at 7 days of age.

[0125] 2.5 Results and Analysis

[0126] Table 3 Effect of the present invention on piglet production performance

[0127]

[0128]

[0129] Table 4 Effect of the present invention on serum hormone levels and immunoglobulins in 7-day-old piglets

[0130]

[0131] From the results in Table 3, it can be seen that compared with the control group, the Example 1 group can significantly improve the survival rate of weak piglets in the first 7 days, the weaning survival rate and the average daily weight gain, reduce the diarrhea rate of piglets, and the treatment effect is also significantly higher than that of the comparative test group.

[0132] As can be seen from Table 4, compared with the control group and the comparative example group, the functional feed additive product for treating weak piglets obtained in Example 1 of the present invention can improve the levels of serum hormones insulin-like growth factor 1 and growth hormone in 7-day-old piglets after being applied to weak piglets, and also significantly increase the content of immunoglobulin G and immunoglobulin M. These results show that the product of the present invention can improve the level of growth-promoting hormones and immunoglobulin content in weak piglets, improve the immune ability of piglets, and play a role in treating weak piglets.

[0133] Compared with Example 1, Comparative Example 1 does not contain medium-chain triglycerides, Comparative Example 2 does not contain colostrum powder, Comparative Example 3 does not contain specific yolk antibodies, Comparative Example 4 does not contain sodium dimethylglycinate, and Comparative Example 5 does not contain medium-chain triglycerides, colostrum powder, and specific yolk antibodies. Under these conditions, the obtained nutritional feed additives are reduced in terms of the survival rate in the first 7 days, weaning survival rate, average daily weight gain, diarrhea rate, growth hormone level, and immunoglobulin level compared to Example 1 of the present invention. Therefore, the nutritional feed additives of the present invention achieve the purpose of effectively treating weak newborn piglets by selecting and proportioning the raw materials in the formula, so that the ingredients work synergistically.

[0134] Test Example 3

[0135] Due to the excessive gestational age of multiparous sows in a pig farm in Shandong, some or all of the newborn piglets are weak in vitality, do not eat milk or are unable to push milk, cannot stand or stand still, whine, shiver, have diarrhea on the day of birth, etc., and most of them die 1-3 days after birth. It is recommended to use the product prepared in Example 1 of the present invention. For piglets with a birth weight of less than 1kg, 2mL of the present invention is orally taken within 4 hours after birth, once a day, for 3 consecutive days. As a result, it is found that the survival rate of weak piglets within one week is significantly increased, and the weight of piglets after weaning is significantly higher than that of weak piglets that do not use the product of the present invention, and is close to the weight level of normal piglets.

[0136] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the technical principles of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A nutritional feed additive for weak piglets, characterized in that: The weak piglet nutritional feed additive is prepared by weight from 300-500 parts of medium chain triglycerides, 150-350 parts of bovine colostrum powder, 3-7 parts of specific egg yolk antibodies, 1-3 parts of lactic acid, 1-3 parts of citric acid, 10-14 parts of glutamine, 3-7 parts of sodium dimethylglycinate, 80-120 parts of glucose, 3-7 parts of astragalus polysaccharide, 10-14 parts of monocalcium phosphate, 3-7 parts of complex trace elements, 1-3 parts of complex vitamins, and 100-300 parts of whey powder; The composite trace element is prepared from yeast selenium, porphyrin iron, and glycinate zinc in a weight ratio of (2-4): (4-6): (1-3); The vitamin complex is prepared from vitamin A, vitamin D3, vitamin E and vitamin K in a weight ratio of (13-17): (2-6): (65-85): (4-8).

2. The nutritional feed additive for weak piglets according to claim 1, characterized in that: The weak piglet nutritional feed additive is prepared by weight from 350-450 parts of medium-chain triglycerides, 200-300 parts of bovine colostrum powder, 4-6 parts of specific egg yolk antibodies, 1.5-2.5 parts of lactic acid, 1.5-2.5 parts of citric acid, 11-13 parts of glutamine, 4-6 parts of sodium dimethylglycinate, 90-110 parts of glucose, 4-6 parts of astragalus polysaccharide, 11-13 parts of calcium dihydrogen phosphate, 4-6 parts of complex trace elements, 1.5-2.5 parts of complex vitamins, and 150-250 parts of whey powder.

3. The nutritional feed additive for weak piglets according to claim 2, characterized in that: The weak piglet nutritional feed additive is prepared by weight from 400 parts of medium-chain triglycerides, 250 parts of bovine colostrum powder, 5 parts of specific egg yolk antibodies, 2 parts of lactic acid, 2 parts of citric acid, 12 parts of glutamine, 5 parts of sodium dimethylglycinate, 100 parts of glucose, 5 parts of astragalus polysaccharide, 12 parts of monocalcium phosphate, 5 parts of complex trace elements, 2 parts of complex vitamins, and 200 parts of whey powder.

4. The method for preparing the nutritional feed additive for weak piglets according to any one of claims 1 to 3, characterized in that: Medium chain triglycerides, bovine colostrum powder, specific egg yolk antibodies, lactic acid, citric acid, glutamine, sodium dimethylglycinate, glucose, astragalus polysaccharide, calcium dihydrogen phosphate, whey powder, complex trace elements and complex vitamins are weighed according to the total weight ratio and mixed evenly to prepare a premix to obtain a powder.

5. The method for preparing the nutritional feed additive for weak piglets according to claim 4, characterized in that: The premix and softened water are uniformly mixed at a mass volume ratio (w / v) of 1:(0.2-2) to obtain a paste.

6. Use of the nutritional feed additive for weak piglets according to any one of claims 1 to 3 in the preparation of a weak piglet oral dosage form.

7. The use according to claim 6, characterized in that: The weak piglets are piglets with a birth weight of less than 1.0 kg.

Images