A multi-species cell planting system

Abstract

The application discloses a multi-specification cell planting system, which comprises a glue discharging assembly, the glue discharging assembly comprises a glue discharging support, a glue discharging connecting seat is fixedly connected to the glue discharging support, at least two glue discharging clamping modules for clamping a glue discharging module are arranged on the glue discharging connecting seat, a glue discharging moving block capable of moving linearly back and forth is connected to the glue discharging support, a glue discharging supporting seat is fixedly connected to the upper end of the glue discharging moving block, a glue discharging connecting part is arranged on one side of the glue discharging module relative to the glue discharging moving block, a glue discharging connecting module for connecting the glue discharging connecting part is slidably connected to the glue discharging supporting seat; a cell dotting assembly, the cell dotting assembly comprises a glue liquid conveying pipe capable of being adjusted in position, the output end of the glue discharging module is connected to one end of the glue liquid conveying pipe, and the other end of the glue liquid conveying pipe is connected to a cell dotting needle head; the glue discharging module can realize glue discharging actions of different glue discharging modules, so as to adapt to cell culture dishes of different sizes.

Description

Technical Field

[0001] This invention relates to the field of biotechnology, and in particular to a multi-specification cell implantation system. Background Technology

[0002] In the prior art, an invention patent entitled "A Dispensing Device for Cell Factory Processing" with publication number CN113843103 A and publication date of December 28, 2021, is disclosed. It includes a dispensing positioning mechanism and a dispensing fixture for holding cell factory boards. The dispensing positioning mechanism includes a first reciprocating translation mechanism, a second reciprocating translation mechanism, a third reciprocating translation mechanism, a dispensing gun, and a control system. The dispensing fixture is located below one side of the dispensing positioning mechanism and includes a board receiving frame, a support, and a fourth reciprocating translation mechanism. During dispensing, the fourth reciprocating translation mechanism pushes the board receiving frame back below the dispensing gun. When a larger dispensing volume is needed, the dispensing time of the dispensing gun at each position is extended, which cannot guarantee dispensing efficiency. When a smaller dispensing volume is needed, the dispensing time of the dispensing gun at each position is reduced. Increasing or decreasing the dispensing volume requires adjusting the movement of each translation mechanism, making the operation relatively cumbersome. Summary of the Invention

[0003] The purpose of this section is to outline some aspects of embodiments of the present invention and to briefly describe some preferred embodiments. Simplifications or omissions may be made in this section, as well as in the abstract and title of this application, to avoid obscuring the purpose of these documents; however, such simplifications or omissions should not be construed as limiting the scope of the invention.

[0004] In view of the above and / or the dispensing problems in the prior art, the present invention is proposed.

[0005] The technical problem solved by this invention is that it is impossible to adjust the amount of adhesive dispensed without adjusting other mechanisms.

[0006] Therefore, the purpose of this invention is to provide a multi-size cell culture system that allows for easy adjustment of the gel output to accommodate cell culture dishes of different sizes.

[0007] To solve the above-mentioned technical problems, the present invention provides the following technical solution: a multi-specification cell planting system, comprising a dispensing assembly, the dispensing assembly comprising a dispensing bracket, a dispensing connector fixedly connected to the dispensing bracket, at least two dispensing clamping modules for clamping the dispensing module on the dispensing connector, a dispensing moving block capable of reciprocating linear movement connected to the dispensing bracket, a dispensing support fixedly connected to the upper end of the dispensing moving block, a dispensing connection portion provided on the side of the dispensing module opposite to the dispensing moving block, and a dispensing connector module for connecting the dispensing connection portion slidably connected to the dispensing support;

[0008] As a preferred embodiment of the multi-specification dispensing system of the present invention, it further includes a dot cell assembly, wherein the dot cell assembly includes a position-adjustable glue delivery tube, the output end of the dispensing module is connected to one end of the glue delivery tube, and the other end of the glue delivery tube is connected to a dot cell needle.

[0009] As a preferred embodiment of the multi-specification dispensing system of the present invention, it further includes a product connection assembly, wherein the product connection assembly includes a rotatable connection box with a mounting cavity, an angle adjustment shaft is rotatably connected inside the connection box, a product mounting plate is fixedly connected to one end of the angle adjustment shaft extending outside the connection box, a plurality of cell culture dishes are arranged on the product mounting plate, and the cell dispensing needle can extend into the cell culture dish.

[0010] As a preferred embodiment of the multi-specification dispensing system of the present invention, it further includes a cell planting box with a receiving cavity, wherein the dispensing component, the cell dispensing component, and the product connection component are all disposed within the receiving cavity.

[0011] To achieve omnidirectional dispensing, a drive assembly for driving the connecting box to rotate is also included. The drive assembly includes a drive motor disposed outside the receiving cavity and fixed on the cell planting box. A connecting shaft is rotatably connected to the planting box. The upper part of the connecting shaft is connected to the connecting box. The drive motor and the connecting shaft are connected in a transmission connection.

[0012] To further enable the glue dispensing assembly to dispense and dispense liquid, the output end of the glue dispensing module is connected to one end of the first three-way pipe. The other two ends of the first three-way pipe are respectively connected to an inlet check valve and an outlet check valve. The end of the outlet check valve away from the glue dispensing module is connected to the end of the glue delivery pipe away from the cell dotting needle. The glue can be drawn into the glue dispensing module through the inlet check valve, and the glue dispensing module can pump the drawn glue into the glue delivery pipe through the outlet check valve.

[0013] To further facilitate the replacement of different specifications of glue dispensing modules, the glue dispensing connection module includes a sliding connecting block that can slide along the glue dispensing support. The sliding connecting block has two opposing clamping units slidably connected to one side of the clamping module. The two clamping units can move towards or away from each other. The opposing side of the two clamping units has an insertion groove. When the two clamping units move towards each other, they can be inserted into the two ends of the glue dispensing connection part through the insertion groove. When the two clamping units move away from each other, they can move away from the glue dispensing connection part at the same time.

[0014] To further facilitate the connection between the dispensing moving block and the glue-applying connecting part, the sliding connecting block also includes a connecting transmission component. The connecting transmission component includes a slide rod, and a transmission block is fixed to the lower side of the slide rod. Both ends of the transmission block have inclined surfaces. On the side of the sliding connecting block opposite to the clamping unit, from top to bottom, there are an upper slot, a sliding groove, and a lower slot. The upper end of the sliding connecting block at the upper slot is provided with a limiting groove. The slide rod can move up and down along the limiting groove. On the side of the clamping unit opposite to the sliding connecting block, there is a movable connecting part that can slide along the sliding groove. One end of each of the two movable connecting parts is connected to a compression spring. Under the action of the compression spring, one end of each of the two movable connecting parts always abuts against both sides of the transmission block. The end of the compression spring away from the movable connecting part is connected to the sliding connecting block at the outer edge of the sliding groove.

[0015] As a preferred embodiment of the multi-specification dispensing system of the present invention, wherein: the upper end of the transmission block can abut against the limiting step at the upper end of the upper slot, and the bottom of the transmission block can contact the sliding connecting block at the bottom of the lower slot; when the transmission block is pulled up so that its upper end abuts against the lower side of the limiting step, the two clamping units are inserted into the dispensing connection part; when the transmission block is pressed down so that its bottom contacts the sliding connecting block at the bottom of the lower slot, the two clamping units move away from the dispensing connection part.

[0016] As a preferred embodiment of the multi-specification dispensing system of the present invention, the dispensing cell assembly further includes an adhesive delivery connecting bracket that can move in the left-right, front-back, and height directions, and the adhesive delivery pipe is connected to the adhesive delivery connecting bracket.

[0017] Compared with the prior art, this invention achieves the following: by setting up the dispensing component and adjusting the dispensing action of different dispensing modules, the dispensing amount can be adjusted; by setting up the cell dispensing component and the product connection component, the product can be dispensed in all directions, thus improving the cell cultivation effect. Attached Figure Description

[0018] To more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings used in the description of the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort. Wherein:

[0019] Figure 1 The three-dimensional structure of the present invention Figure 1 .

[0020] Figure 2 The three-dimensional structure of the present invention Figure 2 .

[0021] Figure 3This is a three-dimensional structural diagram of the present invention with the connecting box hidden.

[0022] Figure 4 This is a three-dimensional structural diagram of the first workstation in this invention.

[0023] Figure 5 This is the three-dimensional structure of the glue dispensing assembly in this invention. Figure 1 .

[0024] Figure 6 This is a top view of the glue dispensing assembly in this invention.

[0025] Figure 7 for Figure 6 AA view in the middle.

[0026] Figure 8 for Figure 6 BB view in the middle.

[0027] Figure 9 for Figure 8 A magnified view of a section at point C.

[0028] Figure 10 This is the three-dimensional structure of the midpoint cell component in this invention. Figure 1 .

[0029] Figure 11 This is the three-dimensional structure of the midpoint cell component in this invention. Figure 2 .

[0030] Figure 12 for Figure 11 A magnified view of a section at point D.

[0031] Figure 13 for Figure 11 A magnified view of a section at point E in the middle.

[0032] Figure 14 This is a schematic diagram of the connection between the two first tee pipes and the second tee pipe in this invention.

[0033] Figure 15 This is the three-dimensional structure of the glue dispensing assembly in this invention. Figure 2 .

[0034] Figure 16 for Figure 15 A magnified view of a section at point F.

[0035] In the diagram, 100 is the glue dispensing assembly, 101 is the first rotating support, 102 is the fixed plate, 103 is the glue dispensing moving block, 104 is the second rotating support, 105 is the glue dispensing bracket, 106 is the glue dispensing drive motor, 107 is the glue dispensing coupling, 108 is the glue dispensing drive screw, 109 is the glue dispensing support, 110 is the glue dispensing connection module, 110a is the handle, 110b is the sliding connection block, 110b-1 is the limit step, 110b-2 is the slide rail, and 110c is the connection. Transmission components: 110c-1 transmission block, 110c-2 slide rod, 110d clamping unit, 110d-1 first clamping plate, 110d-2 second clamping plate, 110d-3 moving connecting part, 110e sliding connecting part, 110f ball bearing, 110g compression spring, 111 liquid outlet check valve, 112 liquid inlet check valve, 113 first three-way pipe, 114 glue dispensing clamping module, 114a upper clamping seat, 114b lower clamping seat. 115 Glue Dispensing Module, 115a Glue Dispensing Cylinder, 115b Glue Dispensing Connecting Rod, 115c Glue Dispensing Connecting Part, 116 Glue Dispensing Connecting Seat, 117 First Control Valve, 118 Intermediate Pipe, 119 Second Control Valve, 120 Second T-Connector, 200 Cell Assembly, 201 Second Horizontal Transmission Screw, 202 Horizontal Crossbeam, 203 Cell Connection Bracket, 204 Side Transmission Box, 205 Lower Transmission Box, 206 Fixed Housing, 207 Lifting Crossbeam, 208 Cell Needle, 209 Glue Delivery Pipe, 210 Glue Delivery Connecting Bracket, 211 Second Moving Block, 212 Lifting Block, 213 Lifting Transmission Screw, 214 First Moving Block, 215 First Horizontal Transmission Screw, 216 Transmission Wheel, 217 Drive Wheel, 218 First 219 Lifting driven wheel, 220 Lifting transmission motor, 221 Lifting drive wheel, 300 Product connection assembly, 301 Connection box, 302 Angle adjustment motor, 303 Product mounting plate, 304 Angle adjustment shaft, 305 Second angle adjustment rotating wheel, 306 Fourth transmission belt, 307 First angle adjustment rotating wheel, 308 Cell culture dish, 400 Planting box, 500 Drive assembly, 501 Second rotating wheel, 502 Third transmission belt, 503 First rotating wheel, 504 Connection shaft, 505 Drive motor, 600 Flexible support, 700 Glue supply device, 800 Fixed support, a Lower slot, b Sliding groove, c Upper slot, d Connecting hole, f Sliding groove, g Supporting groove, h Upper positioning hole, i Insertion groove. Detailed Implementation

[0036] To make the above-mentioned objects, features and advantages of the present invention more apparent and understandable, the specific embodiments of the present invention will be described in detail below with reference to the accompanying drawings.

[0037] Many specific details are set forth in the following description in order to provide a full understanding of the invention. However, the invention may also be practiced in other ways different from those described herein, and those skilled in the art can make similar extensions without departing from the spirit of the invention. Therefore, the invention is not limited to the specific embodiments disclosed below.

[0038] Secondly, the term "one embodiment" or "embodiment" as used herein refers to a specific feature, structure, or characteristic that may be included in at least one implementation of the present invention. The phrase "in one embodiment" appearing in different places in this specification does not necessarily refer to the same embodiment, nor is it a single or selective embodiment that is mutually exclusive with other embodiments.

[0039] Example 1

[0040] Reference Figure 1 , Figure 4 and Figure 5 This embodiment provides a multi-size cell planting system that can adjust the amount of adhesive dispensed to accommodate products of different sizes.

[0041] A multi-specification cell planting system includes a gel dispensing component 100, a cell dotting component 200, and a cell planting box 400 with a receiving cavity. Both the gel dispensing component 100 and the cell dotting component 200 are disposed in the receiving cavity. The receiving cavity is also provided with a gel supply device 700 for supplying gel solution to the gel dispensing component 100 (which is prior art and not an improvement of this application, and will not be described in detail here).

[0042] Furthermore, the dispensing assembly 100 includes a dispensing bracket 105, on which a dispensing connector 116 is fixedly connected. The dispensing connector 116 is provided with at least two dispensing clamping modules 114 for clamping the dispensing module 115. A dispensing moving block 103 capable of reciprocating linear movement is connected to the dispensing bracket 105. A dispensing support 109 is fixedly connected to the upper end of the dispensing moving block 103. The dispensing module 115 has a dispensing connection portion 115c on one side opposite the dispensing moving block 103. A sliding connection portion 115c is provided on the dispensing support 109. A glue dispensing connection module 110 is provided for connecting the glue dispensing connection part 115c. The glue dispensing connection module 110 includes two clamping units 110d that can move towards or away from each other. The clamping units 110d have insertion slots i that can be inserted into the glue dispensing connection part 115c. When the two clamping units 110d move towards each other, the two clamping units 110d can be inserted into the two ends of the glue dispensing connection part 115c through the insertion slots i. When the two clamping units 110d move away from each other, the two clamping units 110d can move away from the glue dispensing connection part 115c at the same time.

[0043] The structure that enables the movement of the dispensing moving block 103 is as follows: one end of the dispensing bracket 105 is fixedly connected to a dispensing drive motor 106, and the other end of the dispensing bracket 105 is fixedly connected to a first rotating support seat 101. A dispensing output shaft is connected to the dispensing drive motor 106, and a second rotating support seat 104 is also fixedly connected to the dispensing bracket 105. The dispensing output shaft is connected to a dispensing drive screw 108 via a dispensing coupling 107. The two ends of the dispensing drive screw 108 are rotatably connected to the first rotating support seat 101 and the second rotating support seat 104, respectively. The dispensing moving block 103 is threadedly connected to the dispensing drive screw 108 and slidably connected to the dispensing bracket 105. Several fixing plates 102 are arranged on the lower side of the dispensing bracket 105. A fixing bracket 800 is fixedly connected to the inner wall of the cell planting box 400, and the fixing plates 102 are fixedly connected to the fixing bracket 800.

[0044] Furthermore, the dot cell assembly 200 includes a glue delivery connection bracket 210 that can move in the left-right, front-back and height directions. A glue delivery tube 209 is connected to the glue delivery connection bracket 210. The output end of the glue dispensing module 115 is connected to one end of the glue delivery tube 209, and the other end of the glue delivery tube 209 is connected to the dot cell needle 208.

[0045] The glue dispensing module 115 includes a glue dispensing cylinder 115a. A piston capable of reciprocating linearly along the inner wall of the glue dispensing cylinder 115a is connected inside the glue dispensing cylinder 115a. The space between the piston and the inner wall of the glue dispensing cylinder 115a is a closed cavity. A glue dispensing connecting rod 115b is provided on the side of the piston opposite to the glue dispensing connecting seat 116. A glue dispensing connecting part 115c is fixed to the end of the glue dispensing connecting rod 115b that extends out of the glue dispensing cylinder 115a. The end of the glue dispensing cylinder 115a away from the glue dispensing connecting seat is connected to the glue delivery pipe 209. The output end of the glue supply device 700 is connected to the output end of the glue dispensing cylinder 115a via a pipe (which is prior art and not shown). Select a suitable dispensing module 115 according to the specifications of the product to be dispensed, ensuring it meets the dispensing time requirements. Initially, the gap between the two clamping units 110d is greater than the maximum distance of the outer edge contour of the dispensing connection part 115c, meaning the two clamping units 110d are facing outwards from both ends of the dispensing connection part 115c, while simultaneously moving axially away from the dispensing module 115. The specific replacement process involves connecting the corresponding dispensing cylinder 115a to the adhesive delivery pipe 209, allowing the dispensing connection module 110 to slide horizontally along the dispensing support base 109. When the dispensing connection module 110 faces the corresponding dispensing connection part 115c, stop sliding the dispensing connection module 110, activate the dispensing drive motor 106, and rotate the dispensing output shaft. The dispensing output shaft drives the dispensing drive screw 108 to rotate via the dispensing coupling 107. The dispensing drive screw 108 drives the dispensing connection module 110 to move via the dispensing support seat 109, controlling the direction of the dispensing drive motor 106. This causes the dispensing connection module 110 to move towards the dispensing module 115. When the insertion slot i aligns with the dispensing connection part 115c, the dispensing drive motor 106 stops, and the two clamping units 110d move towards each other. When the two clamping units 110d are inserted into the dispensing connection part 115c via their corresponding insertion slot i, the two clamping units 110d stop moving, thus connecting the dispensing moving block 103 and the dispensing connection part 115c. During the dispensing operation, the dispensing drive motor 106 operates. The dispensing drive screw 108 rotates, driving the dispensing moving block 103 to slide along the length of the dispensing bracket 105. The dispensing moving block 103 drives the piston to move sequentially through the dispensing support 109, the dispensing connection module 110, and the dispensing connection part 115c. When drawing liquid, the direction of action of the dispensing drive motor 106 is controlled, causing the dispensing connection module 110 to move in the direction of the second rotating support 104. When dispensing glue, the dispensing drive motor 106 is reversed, causing the dispensing connection module 110 to move in the direction of the first rotating support 101, thereby realizing the extraction and dispensing of glue.

[0046] Before dispensing, adjust the position of the cell dispensing needle 208, controlling its upward movement to a suitable position above the top of the product. Adjust the left-right position of the cell dispensing needle 208 so that it moves towards the product mounting plate 303. When the cell dispensing needle 208 is aligned with the product, stop moving it and lower it to a suitable dispensing position. During dispensing, the glue dispensed from the glue dispensing cartridge 115a is discharged from the cell dispensing needle 208 through the glue delivery tube 209. The cell dispensing needle 208 is then aimed at the product. Adjust the front-back position of the cell dispensing needle 208 so that it dispenses along the product's axial direction. After the first dispensing operation is completed, adjust the position of the cell dispensing needle 208 so that it leaves the cell culture dish 308, preparing for the next dispensing operation.

[0047] Furthermore, the glue dispensing clamping module 114 includes a lower clamping seat 114b, with an upper clamping seat 114a detachably connected to the upper clamping seat 114b at its upward-facing end. The upper clamping seat 114a and the lower clamping seat 114b are respectively provided with a plurality of upper fastening holes and lower fastening holes. The upper clamping seat 114b is provided with an upper clamping groove on its upward-facing side, and the upper clamping seat 114a is provided with a lower clamping groove on its downward-facing side. When installing the glue dispensing module 115, the glue dispensing cylinder 115a is placed in the lower clamping groove, the upper clamping seat 114a is closed, and a plurality of clamping bolts are screwed into the upper fastening holes and the lower fastening holes in sequence, so that the glue dispensing cylinder 115a is clamped between the upper clamping seat 114a and the lower clamping seat 114b, thereby fixing the glue dispensing cylinder 115a.

[0048] To further enable the glue dispensing assembly 100 to dispense and dispense liquid, the output end of the glue dispensing module 115 is connected to one end of the first three-way pipe 113. The other two ends of the first three-way pipe 113 are respectively connected to the inlet one-way valve 112 and the outlet one-way valve 111. The end of the outlet one-way valve 111 away from the glue dispensing module 115 is connected to the end of the glue delivery pipe 209 away from the cell needle 208. The glue can be drawn into the glue dispensing module 115 through the inlet one-way valve 112, and the glue dispensing module 115 can pump the drawn glue into the glue delivery pipe 209 through the outlet one-way valve 111.

[0049] In this embodiment, before applying the adhesive, the corresponding first three-way pipe 113 and adhesive delivery pipe 209 are connected. When extracting the adhesive, the adhesive in the adhesive supply device 700 enters the closed cavity formed between the piston and the inner wall of the adhesive application cylinder 115a through the pipe and the inlet one-way valve 112. When applying the adhesive, the adhesive in the closed cavity is pumped into the adhesive delivery pipe 209 through the outlet one-way valve 111. By setting the adhesive application component 100, the adhesive application action of different adhesive application modules 115 can be realized. Different specifications of adhesive application modules 115 have different adhesive application amounts when the moving block 103 moves at the same speed. According to the size of the cell culture dish 308, the moving block 103 and the adhesive application connection part 115c of the appropriate adhesive application module 115 are connected. Cell planting of cell culture dishes 308 of different sizes can be realized without replacing the entire equipment, reducing costs.

[0050] Example 2

[0051] Reference Figure 2 and Figure 3 This embodiment provides a multi-size cell planting system, which is based on the previous embodiment and can further achieve omnidirectional dispensing.

[0052] Specifically, it also includes a product connection assembly 300, which includes a rotatable connection box 301 with a mounting cavity. An angle adjustment shaft 304 is rotatably connected inside the connection box 301. One end of the angle adjustment shaft 304 extending out of the connection box 301 is fixedly connected to a product mounting plate 303. Several cell culture dishes 308 are arranged on the product mounting plate 303, and cell dispensing needles 208 can extend into the cell culture dishes 308.

[0053] To achieve omnidirectional dispensing, a drive assembly 500 for driving the connecting box 301 to rotate is also included. The drive assembly 500 includes a drive motor 505 disposed outside the receiving cavity and fixed on the cell planting box 400. A connecting shaft 504 is rotatably connected to the planting box 400. The upper part of the connecting shaft 504 is connected to the connecting box 301. The drive motor 505 and the connecting shaft 504 are connected in a transmission connection. Specifically, the end of the connecting shaft 504 extending outside the receiving cavity is connected to a first rotating wheel 503, and a second rotating wheel 503 is connected to the drive motor 505. 01. The first rotating wheel 503 is connected to the second rotating wheel 501 via the third transmission belt 502; an angle adjusting motor 302 is fixedly connected inside the connecting box 301. The angle adjusting motor 302 and the angle adjusting shaft 304 are connected by a transmission. Specifically, the angle adjusting motor 302 is connected to the first angle adjusting rotating wheel 307, and one end of the angle adjusting shaft 304 inside the connecting box 301 is connected to the second angle adjusting rotating wheel 305. The first angle adjusting rotating wheel 307 is connected to the second angle adjusting rotating wheel 305 via the fourth transmission belt 306.

[0054] In the initial stage, the connection box 301 is located behind the product mounting plate 303, and the cell culture dish 308 is positioned relative to the cell assembly 200, as shown below. Figure 4 As shown, the product mounting plate 303 is in a vertical position. Taking cell seeding on a cylindrical flexible scaffold 600 as an example, the flexible scaffold 600 is installed in a cell culture dish 308. The position of the cell dispensing needle 208 is adjusted so that it is aligned with the top of the flexible scaffold 600. At this position, the dispensing is completed, and the cell dispensing needle 208 moves away from the cell culture dish 308. The connecting box 301 rotates to the front, and the product mounting plate 303 rotates to the rear. At this time, the cell culture dish 308 is facing away from the cell dispensing component 200. The product mounting plate 303 is rotated 180° so that the cell culture dish 308 is facing the cell dispensing component 200. At the same time, the original bottom end of the flexible scaffold 600 is flipped upwards, becoming the top end of the flexible scaffold 600. The position of the cell dispensing needle 208 is adjusted so that it is aligned with the top end of the flexible scaffold 600, thereby achieving omnidirectional dispensing of the flexible scaffold 600.

[0055] When the angle of the connecting box 301 needs to be adjusted, the drive motor 505 is activated, the second rotating wheel 501 rotates, the second rotating wheel 501 drives the first rotating wheel 503 to rotate via the third transmission belt 502, and the first rotating wheel 503 drives the connecting box 301 to rotate via the connecting shaft 504. When the connecting box 301 rotates to the appropriate angle, the drive motor 505 stops. When the angle of the product mounting plate 303 needs to be adjusted, the angle adjustment motor 302 is activated, the first angle adjustment rotating wheel 307 rotates, the first angle adjustment rotating wheel 307 drives the second angle adjustment rotating wheel 305 to rotate via the fourth transmission belt 306, and the second angle adjustment rotating wheel 305 drives the product mounting plate 303 to rotate via the angle adjustment shaft 304. When the cell culture dish 308 rotates to the appropriate angle, the angle adjustment motor 302 stops.

[0056] Example 3

[0057] Reference Figures 6-9 , Figure 15 and Figure 16 This embodiment provides a multi-specification cell planting system. Based on the previous two embodiments, this embodiment can further realize the replacement of different specifications of glue dispensing modules 115.

[0058] Specifically, the dispensing connection module 110 includes a connecting transmission component 110c and a sliding connecting block 110b that can slide along the dispensing support base 109. The sliding connecting block 110b has a screw hole and a sliding support hole offset from the screw hole. The axes of the sliding support hole and the screw hole are perpendicular to each other. The sliding connecting block 110b is threadedly connected to a sliding connecting component 110e via the sliding support hole. A ball bearing 110f is movably connected inside the sliding connecting rod. A support groove g is provided on the upward-facing side of the dispensing support base 109. The inner edges of both sides of the dispensing support base 109 can slide along the front and rear sides of the upper end of the dispensing support base 109. The ball bearing 110f can roll along the support groove g. Several connecting holes d are arranged on the dispensing support base 109. The screw hole can be coaxial with any of the connecting holes d. Two clamping units 110d are slidably connected to the side of the sliding connecting block 110b opposite to the clamping module. The connecting transmission component 110c includes a sliding rod. 110c-2, a transmission block 110c-1 is fixed to the lower side of the slide rod 110c-2. Both ends of the transmission block 110c-1 have inclined surfaces. The sliding connecting block 110b has an upper slot c, a sliding groove b, and a lower slot a sequentially formed from top to bottom on the side opposite to the clamping unit 110d. The upper end of the upper slot c has a limiting groove on the sliding connecting block 110b. The slide rod 110c-2 can move up and down along the limiting groove. The clamping unit 110d moves relative to the sliding... One side of the connecting block 110b is fixed with a movable connecting part 110d-3 that can slide along the sliding groove b. One end of each movable connecting part 110d-3 is connected to a compression spring 110g. Under the action of the compression spring 110g, one end of each movable connecting part 110d-3 is always in contact with both sides of the transmission block 110c-1. The end of the compression spring 110g away from the movable connecting part 110d-3 is connected to the sliding connecting block 110b at the outer edge of the sliding groove b.

[0059] When the position of the sliding connecting block 110b is adjusted, the screw is screwed into the screw hole and the connecting hole d to fix the sliding connecting block 110b to the glue dispensing support 109, thereby fixing the sliding connecting block 110b; in order to facilitate the screwing in, a handle 110a is fixedly connected to the outer end of the screw.

[0060] Furthermore, the upper end of the transmission block 110c-1 can abut against the limiting step 110b-1 at the upper end of the upper slot c, and the bottom of the transmission block 110c-1 can contact the sliding connecting block 110b at the bottom of the lower slot a; when the transmission block 110c-1 is pulled up so that its upper end abuts against the lower side of the limiting step 110b-1, the two clamping units 110d are inserted into the glue-applying connecting part 115c; when the transmission block 110c-1 is pressed down so that its bottom contacts the sliding connecting block 110b at the bottom of the lower slot a, the two clamping units 110d move away from the glue-applying connecting part 115c.

[0061] Furthermore, the clamping unit 110d includes a first clamping plate 110d-1 slidably connected to it, a second clamping plate 110d-2 connected to the side of the first clamping plate 110d-1 away from the sliding connecting block 110b, a movable connecting part 110d-3 fixed to the end of the first clamping plate 110d-1 away from the second clamping plate 110d-2, and an insertion groove i is opened on the side of the first clamping plate 110d-1 and the second clamping plate 110d-2 that are opposite to each other.

[0062] Preferably, the upper and lower ends of the movable connecting part 110d-3 are respectively provided with sliding grooves f, and the sliding connecting blocks 110b on both sides of the sliding grooves f are provided with slide rails 110b-2. The movable connecting part 110d-3 is slidably connected to the slide rails 110b-2 through the sliding grooves f. Under the action of the sliding grooves f and the slide rails 110b-2, the movable connecting part 110d-3 cannot move up and down or back and forth, and can only move left and right.

[0063] In actual implementation, limiting holes can be opened at the upper and lower parts of the sliding connecting block 110b, and upper positioning holes h can be opened on the slide rod 110c-2 (e.g., Figure 16 As shown), a lower positioning hole is provided on the transmission block 110c-1, so that when the upper end of the transmission block 110c-1 abuts against the limiting step 110b-1, the upper positioning hole h and the upper limiting hole are coaxial; when the bottom of the transmission block 110c-1 contacts the sliding connecting block 110b at the bottom of the lower slot a, the lower limiting hole and the lower positioning hole are coaxial; the inner edge of the movable connecting part 110d-3 is preferably set as semi-circular. In the initial state, the inner edges of the two oppositely arranged movable connecting parts 110d-3 abut against the inclined surfaces on both sides of the transmission block 110c-1 under the action of the compression spring 110g, and the sliding connecting block 110b at the bottom of the lower slot a of the transmission block 110c-1 contacts. A positioning pin is used to pass through the lower limiting hole and the lower positioning hole, so that... The position of the connecting transmission component 110c in the height direction is fixed. When the sliding rod 110c-2 is pulled up, the transmission block 110c-1 moves upward, and the moving connecting part 110d-3 moves in the direction of the inclined surface under the elastic force of the compression spring 110g. The moving connecting part 110d-3 can always abut against the transmission block 110c-1. The moving connecting part 110d-3 drives the first clamping plate 110d-1 to slide in the direction of the center of the connecting transmission component 110c in the left and right directions. When the clamping unit 110d clamps the glue dispensing connecting part and the upper end of the transmission block 110c-1 contacts the lower side of the limiting step 110b-1, the positioning pin passes through the upper limiting hole and the upper positioning hole h to fix the position of the connecting transmission component 110c in the height direction.

[0064] The configuration of each hole is based on existing technology. Limiting holes, lower positioning holes, etc., are not shown in this application, but they do not affect the understanding of the connection structure by those skilled in the art.

[0065] This embodiment facilitates the connection between the dispensing moving block 103 and the dispensing connecting part, and makes it more convenient to replace the dispensing module 115 of different specifications.

[0066] Example 4

[0067] Reference Figures 10-13 This embodiment provides a multi-specification cell planting system. Based on the above three embodiments, this embodiment can further realize the position adjustment of the gel delivery connection bracket.

[0068] Furthermore, the dot cell assembly 200 also includes a lower transmission box 205 fixed inside the cell planting box 400. A lifting transmission motor 220 is fixedly connected to the upper side of the lower transmission box 205. A lifting drive wheel 221 is rotatably connected inside the lower transmission box 205. The lifting transmission motor 220 and the lifting drive wheel 221 are connected. A fixed housing 206 is fixedly connected to the upper side of the lower transmission box 205. A lifting transmission screw 213 is rotatably connected inside the fixed housing 206. The lifting transmission screw 213 extends into... One end of the lower transmission box 205 is connected to a lifting driven wheel 219, and the lifting driving wheel 221 is connected to the lifting driven wheel 219 via a first transmission belt; a lifting block 212 on a slidingly connected fixed housing 206 is threaded onto the lifting transmission screw 213, and a lifting beam 207 is fixedly connected to one end of the lifting block 212 extending out of the fixed housing 206; a side transmission box 204 is fixedly connected to the end of the lifting beam 207, and a drive wheel 217 and a transmission wheel 21 are rotatably connected inside the side transmission box 204. 6. A first moving motor 218 is fixedly connected to the outside of the side transmission box 204. The first moving motor 218 is connected to the drive wheel 217. The drive wheel 217 is connected to the transmission wheel 216 via a second transmission belt. A first horizontal transmission screw 215 is rotatably connected to the lifting beam 207. A first moving block 214 is threadedly connected to the first horizontal transmission screw 215 and slidably connected to the lifting beam 207. One end of the first moving block 214 extending out of the lifting beam 207 is fixedly connected to a point cell connection bracket 203. A horizontal beam 202 is fixedly connected to the point cell connection bracket 203. The length direction of the horizontal beam 202 is perpendicular to the length direction of the lifting beam 207. A second moving motor is fixedly connected to one end of the horizontal beam 202 near the fixed housing 206. A second horizontal transmission screw 201 is connected to the second moving motor. A second moving block 211 is threadedly connected to the second horizontal transmission screw 201 and slidably connected to the horizontal beam 202. A glue dispensing conveyor bracket is fixedly connected to the second moving block 211.

[0069] When the position of the dispensing conveyor bracket in the height direction needs to be adjusted, the lifting drive motor 220 is activated, and the lifting drive wheel 221 rotates. The lifting drive wheel 221 drives the lifting driven wheel 219 to rotate via the first transmission belt. The lifting driven wheel 219 drives the lifting drive screw 213 to rotate. The lifting drive screw 213 drives the cell delivery bracket to move via the lifting block 212, the lifting beam 207, and the cell-point connection bracket 203 in sequence. When the cell-point needle 208 is raised or lowered to the required position, the lifting drive motor 220 stops. When the position of the cell-point needle 208 in the left or right direction needs to be adjusted, the first moving motor 218 is activated, and the drive wheel 217 rotates. The drive wheel 217 drives the transmission wheel 216 to rotate via the second transmission belt. The transmission wheel 216 drives the first horizontal transmission... When the lead screw 215 rotates, the first horizontal transmission lead screw 215 drives the first moving block 214 to move. The first moving block 214 drives the cell delivery support to move along the length of the lifting beam 207. When the cell delivery support moves to the appropriate position, the first moving motor 218 stops. When it is necessary to adjust the position of the cell delivery needle 208 in the front-back direction, the second moving motor operates, the second horizontal transmission lead screw 201 rotates, and the second horizontal transmission lead screw 201 drives the second moving block 211 to move along the length of the horizontal beam 202. When the second moving block 211 drives the dispensing delivery support to move back and forth to the required position, the second moving motor stops. By adjusting the position of the cell delivery needle 208, dispensing of products such as the flexible scaffold 600 is achieved.

[0070] Example 5

[0071] Reference Figure 14 This embodiment provides a multi-specification cell implantation system. Based on the above four embodiments, this embodiment can achieve the connection of different first three-way tubes 113 and glue delivery tubes 209.

[0072] In this embodiment, there are two glue dispensing clamping modules 114. The end of the glue delivery tube 209 away from the cell dot needle 208 is connected to one end of the second three-way tube 120. The output ends of the two liquid dispensing one-way valves 111 are respectively connected to intermediate tubes 118. The ends of the two intermediate tubes 118 away from the corresponding liquid dispensing one-way valves 111 are respectively connected to the first control valve 117 and the second control valve 119. The ends of the first control valve 117 and the second control valve 119 away from the corresponding intermediate tubes 118 are respectively connected to the other two ends of the second three-way tube 120.

[0073] In the initial state, both the first control valve 117 and the second control valve 119 are de-energized and closed. When it is necessary to connect one of the first three-way pipes 113 (which is connected to the first control valve 117 via the corresponding liquid outlet check valve 111 and the intermediate pipe 118) and the adhesive delivery pipe 209, the first control valve 117 is energized and opened. The adhesive from the corresponding glue dispensing cartridge 115a is dispensed from the first three-way pipe 113, passes through the first control valve 117 and the second three-way pipe 120, and then enters the adhesive delivery pipe 209 to achieve dispensing under this specification.

[0074] In the above embodiments, neither the first transmission belt nor the second transmission belt is shown, as they are existing technologies and do not affect the understanding of their connection method by those skilled in the art.

[0075] It should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and are not intended to limit it. Although the present invention has been described in detail with reference to preferred embodiments, those skilled in the art should understand that modifications or equivalent substitutions can be made to the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention, and all such modifications or substitutions should be covered within the scope of the claims of the present invention.

Claims

1. A multi-specification cell implantation system, characterized in that: It includes; A glue dispensing assembly (100) includes a glue dispensing bracket (105), a glue dispensing connector (116) is fixedly connected to the glue dispensing bracket (105), and at least two glue dispensing clamping modules (114) for clamping the glue dispensing module (115) are provided on the glue dispensing connector (116). A glue dispensing moving block (103) capable of reciprocating linear movement is connected to the glue dispensing bracket (105). A glue dispensing support base (109) is fixedly connected to the upper end of the glue dispensing moving block (103). A glue dispensing connecting part (115c) is provided on one side of the glue dispensing module (115) opposite to the glue dispensing moving block (103). A glue dispensing connecting module (110) for connecting the glue dispensing connecting part (115c) is slidably connected to the glue dispensing support base (109). Dot cell assembly (200), the dot cell assembly (200) includes a position-adjustable glue delivery tube (209), the output end of the glue dispensing module (115) is connected to one end of the glue delivery tube (209), and the other end of the glue delivery tube (209) is connected to a dot cell needle (208); Product connection assembly (300), the product connection assembly (300) includes a rotatable connection box (301) with a mounting cavity, an angle adjustment shaft (304) is rotatably connected inside the connection box (301), a product mounting plate (303) is fixedly connected to one end of the angle adjustment shaft (304) extending out of the connection box (301), a plurality of cell culture dishes (308) are arranged on the product mounting plate (303), and the cell spotting needle (208) can extend into the cell culture dish (308); In the initial stage, the connecting box (301) is behind the product mounting plate (303), the cell culture dish (308) is positioned relative to the cell dispensing assembly (200), the product mounting plate (303) is in a vertical position, and the flexible support (600) is installed inside the cell culture dish (308). The position of the cell dispensing needle (208) is adjusted so that it is aligned with the top of the flexible support (600). At this stage, dispensing is complete, the cell dispensing needle (208) is moved away from the cell culture dish (308), the connecting box (301) rotates to the front, and the product dispensing... The mounting plate (303) is rotated to the rear. At this time, the cell culture dish (308) is facing away from the dot cell assembly (200). The product mounting plate (303) is rotated 180° and the cell culture dish (308) is facing the dot cell assembly (200). At the same time, the original bottom end of the flexible scaffold (600) is flipped upwards, becoming the top end of the flexible scaffold (600). The position of the dot cell needle (208) is adjusted so that the dot cell needle (208) is aligned with the top end of the flexible scaffold (600), thereby realizing the all-round dot cell dispensing of the flexible scaffold (600).

2. The multi-size cell implantation system as described in claim 1, characterized in that: It also includes a cell planting box (400) with a receiving cavity, wherein the gel dispensing assembly (100), the dot cell assembly (200) and the product connection assembly (300) are all disposed within the receiving cavity.

3. The multi-size cell implantation system as described in claim 2, characterized in that: It also includes a drive assembly (500) for driving the connecting box (301) to rotate. The drive assembly (500) includes a drive motor (505) disposed outside the receiving cavity and fixed on the cell planting box (400). A connecting shaft (504) is rotatably connected to the planting box (400). The upper part of the connecting shaft (504) is connected to the connecting box (301). The drive motor (505) and the connecting shaft (504) are connected in a transmission connection.

4. The multi-specification cell implantation system as described in any one of claims 1 to 3, characterized in that: The output end of the glue dispensing module (115) is connected to one end of the first three-way pipe (113). The other two ends of the first three-way pipe (113) are respectively connected to an inlet check valve (112) and an outlet check valve (111). The end of the outlet check valve (111) away from the glue dispensing module (115) is connected to the end of the glue delivery pipe (209) away from the cell dotting needle (208). The glue can be drawn into the glue dispensing module (115) through the inlet check valve (112), and the glue dispensing module (115) can pump the drawn glue into the glue delivery pipe (209) through the outlet check valve (111).

5. The multi-specification cell implantation system as described in any one of claims 1 to 3, characterized in that: The dispensing connection module (110) includes a sliding connection block (110b) that can slide along the dispensing support (109). The sliding connection block (110b) has two opposing clamping units (110d) slidably connected to one side of the dispensing clamping module (114). The two clamping units (110d) can move towards or away from each other. The opposing side of the two clamping units (110d) has an insertion groove (i). When the two clamping units (110d) move towards each other, they can be inserted into both ends of the dispensing connection part (115c) through the insertion groove (i). When the two clamping units (110d) move away from each other, they can move away from the dispensing connection part (115c) at the same time.

6. The multi-size cell implantation system as described in claim 5, characterized in that: The sliding connecting block (110b) further includes a connecting transmission component (110c), which includes a slide rod (110c-2). A transmission block (110c-1) is fixed to the lower side of the slide rod (110c-2). Both ends of the transmission block (110c-1) have inclined surfaces. On the side of the sliding connecting block (110b) opposite to the clamping unit (110d), an upper slot (c), a sliding groove (b), and a lower slot (a) are sequentially formed from top to bottom. A limiting groove is provided on the sliding connecting block (110b) at the upper end of the upper slot (c). The slide rod (110c-2) can just fit... Moving up and down along the limiting slide groove, the clamping unit (110d) has a movable connecting part (110d-3) fixed on one side of the sliding connecting block (110b) that can slide along the sliding groove (b). One end of each movable connecting part (110d-3) is connected to a compression spring (110g). Under the action of the compression spring (110g), one end of each movable connecting part (110d-3) is always in contact with both sides of the transmission block (110c-1). The end of the compression spring (110g) away from the movable connecting part (110d-3) is connected to the sliding connecting block (110b) at the outer edge of the sliding groove (b).

7. The multi-size cell implantation system as described in claim 6, characterized in that: The upper end of the transmission block (110c-1) can abut against the limiting step (110b-1) at the upper end of the upper slot (c), and the bottom of the transmission block (110c-1) can contact the sliding connecting block (110b) at the bottom of the lower slot (a). When the transmission block (110c-1) is pulled up so that its upper end abuts against the lower side of the limiting step (110b-1), the two clamping units (110d) are inserted into the glue-applying connecting part (115c). When the transmission block (110c-1) is pressed down so that its bottom contacts the sliding connecting block (110b) at the bottom of the lower slot (a), the two clamping units (110d) move away from the glue-applying connecting part (115c).

8. The multi-specification cell implantation system as described in any one of claims 1 to 3, characterized in that: The dot cell assembly (200) also includes an adhesive delivery connection bracket (210) movable in the left-right, front-back and height directions, and the adhesive delivery pipe (209) is connected to the adhesive delivery connection bracket (210).

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