A method and system for preparing a mixed liquid for producing colloidal colloids

Abstract

This invention discloses a method for producing a mixed liquid for making colloidal colloids, comprising: discharging, placing the liquids to be mixed in the same container, and driving a drive rod with a motor to move the liquid into a cavity; circulating, controlling the liquid outflow according to the interaction between the drive rod and a steel ball in the cavity, and returning it to the container; pressurizing, allowing the circulated liquid to flow back into the cavity, and pressurizing the outflowing liquid by changing the cross-sectional area of ​​the outlet pipe with a pressure rod; alternating between circulation and pressurization to form a homogeneous mixed liquid. This invention utilizes the circulation step to achieve homogeneous mixing of the liquid on a large scale; and the pressurization step to achieve homogeneous mixing of the liquid on a small scale. This invention is convenient to operate, provides precise control, and does not damage the cohesive force of the liquid.

Description

Technical Field

[0001] This invention relates to the field of biomedicine. Specifically, it relates to a method and system for preparing a mixed liquid for producing clonidine colloid. Background Technology

[0002] Clonidine has a wide range of applications and is used to treat a variety of diseases, such as severe hypertension, hypertension with glaucoma, migraines, and severe dysmenorrhea. It plays an important role in the medical field, so the preparation of clonidine is of great significance.

[0003] However, the process of synthesizing clonidine is complex, and the environmental requirements for liquid mixing are strict, as are the requirements for the liquid mixing effect. The clonidine obtained by existing preparation methods and equipment has poor performance. Summary of the Invention

[0004] The present invention is proposed based on the above-mentioned needs of the prior art. The technical problem to be solved by the present invention is to improve the liquid mixing effect and improve the performance of the prepared clonidine.

[0005] To solve the above problems, the present invention is implemented using the following technical solution:

[0006] A method for preparing a mixed liquid for producing colloidal colloid, the method comprising:

[0007] The process involves placing the liquids to be mixed into the same container, and then using a motor to drive a drive rod to move the liquid into the cavity.

[0008] The circulation is controlled by the interaction between the drive rod and the steel ball in the cavity, allowing the liquid to flow out and return to the container.

[0009] Pressurization is applied to allow the circulated liquid to flow back into the cavity. The cross-sectional area of ​​the outlet pipe is changed by a pressure rod to pressurize the outflowing liquid.

[0010] The process involves alternating circulation and pressurization to form a homogeneous liquid mixture.

[0011] Optionally, the step of driving a drive rod to move via a motor to allow liquid to flow into the cavity includes:

[0012] The motor drives the drive rod to extend downwards out of the cavity, causing liquid to flow into the cavity according to the pressure difference, and the steel ball moves to the small hole connecting the cavity and the liquid outlet pipe.

[0013] Optionally, controlling the liquid flow out and back into the container based on the cooperation between the drive rod and the steel ball in the cavity includes:

[0014] The drive rod extends upward into the cavity, generating an impact force to move the position of the steel ball, thereby connecting the cavity with the outlet pipe and returning the liquid to the container through the U-shaped return pipe.

[0015] Optionally, the step of pressurizing the outflowing liquid by changing the cross-sectional area of ​​the outlet pipe using a pressure rod includes:

[0016] The pressure rod, which has a trapezoidal or conical top, is moved by a pressure applying mechanism to change the cross-sectional area of ​​the outlet pipe and pressurize the outflowing liquid. The pressure applying mechanism can be one or more of hydraulic, pneumatic, electrical, or mechanical.

[0017] Optionally, the liquid in the cavity may be circulated or pressurized according to the three-way valve.

[0018] Optionally, the cycle and the pressurization operation alternate twice.

[0019] Optionally, the pressure is controlled between 6-8 MPa, the maximum flow rate is 900 m / s, and the prepared clonidine colloid is less than 20000 cp.

[0020] Optionally, the diameter of the cavity is less than twice the diameter of the steel ball;

[0021] The size of the steel ball is such that when the steel ball is at its maximum height in the cavity, it is tangent to the upper edge of the cavity and the edge near the small hole, respectively, thus just blocking the small hole.

[0022] Optionally, the diameter of the communication hole between the cavity and the liquid inlet pipe is smaller than the diameter of the steel ball;

[0023] The size of the steel ball is such that when the steel ball is at its minimum height in the cavity, it is tangent to the left and right sides of the cavity, respectively, and just blocks the connection hole between the cavity and the liquid inlet pipe.

[0024] A mixed liquid system for producing colloidal colloids, comprising:

[0025] The feeding module is used to place the liquids to be mixed in the same container, and the motor drives the drive rod to move so that the liquid flows into the cavity;

[0026] The circulation module is used to control the liquid flow out and return it to the container based on the cooperation between the drive rod and the steel ball in the cavity;

[0027] The pressurization module is used to recirculate the liquid into the cavity and pressurize the outflowing liquid by changing the cross-sectional area of ​​the outlet pipe through the pressure rod.

[0028] A mixing module is used to alternately execute the circulation module and the pressurization module to form a uniformly mixed liquid.

[0029] Compared with existing technologies, this invention utilizes a cyclic step to achieve uniform mixing of liquids on a large scale; and a pressurization step to achieve uniform mixing of liquids on a small scale. This invention is easy to operate, has precise control, and does not damage the cohesion of the liquid. Attached Figure Description

[0030] To more clearly illustrate the technical solutions in the embodiments of this specification or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments recorded in the embodiments of this specification. For those skilled in the art, other drawings can be obtained based on these drawings.

[0031] Figure 1 This is a flowchart of a mixed liquid method for preparing colloidal colloid provided by a specific embodiment of the present invention;

[0032] Figure 2 This is a schematic diagram of the structure of the mixing liquid device provided in a specific embodiment of the present invention. Detailed Implementation

[0033] To make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, the technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0034] To facilitate understanding of the embodiments of the present invention, further explanations and descriptions will be provided below with reference to the accompanying drawings and specific embodiments. These embodiments do not constitute a limitation on the scope of protection of the present invention.

[0035] Example 1

[0036] The synthesis of clonidine is complex, requiring strict environmental conditions and high precision in liquid mixing. To meet these mixing requirements and maximize clonidine's performance, this embodiment provides a method for preparing a clonidine colloid using a mixed liquid, the process of which is as follows: Figure 1 As shown, it includes:

[0037] S1: Discharge: Place the liquids to be mixed into the same container, and drive the drive rod through the motor to make the liquid flow into the cavity;

[0038] S2: Circulation, the liquid is controlled to flow out and return to the container according to the cooperation between the drive rod and the steel ball in the cavity;

[0039] S3: Pressurize, and let the circulated liquid flow back into the cavity. Change the cross-sectional area of ​​the outlet pipe by the pressure rod to pressurize the outflowing liquid;

[0040] S4: Alternately cycle and pressurize to form a homogeneous liquid mixture.

[0041] In this embodiment of the invention, it can be achieved by... Figure 2 The device shown is implemented.

[0042] After placing the liquids to be mixed in the same container, you can simply stir them before letting them flow into the cavity to improve the degree of mixing.

[0043] The method utilizes a cyclic step to achieve uniform mixing of liquids on a large scale; and a pressurization step to achieve uniform mixing of liquids on a small scale. The method provided in this embodiment of the invention is easy to operate, has precise control, and does not damage the cohesive force of the liquid.

[0044] Preferably, the step of driving the drive rod to move via a motor to allow liquid to flow into the cavity includes:

[0045] The motor drives the drive rod to extend downwards out of the cavity, causing liquid to flow into the cavity according to the pressure difference, and the steel ball moves to the small hole connecting the cavity and the liquid outlet pipe.

[0046] With this configuration, the liquid supply can be controlled to fill the cavity to a constant flow rate, based on the interaction between the drive rod and the steel ball inside the cavity.

[0047] Preferably, the step of controlling the liquid flow out and returning it to the container based on the cooperation between the drive rod and the steel ball in the cavity includes:

[0048] The drive rod extends upward into the cavity, generating an impact force to move the position of the steel ball, thereby connecting the cavity with the outlet pipe and returning the liquid to the container through the U-shaped return pipe.

[0049] The steel ball inside the cavity acts as a valve, controlling whether the cavity can connect to the outlet pipe. When the liquid level in the cavity rises to the connection point, the steel ball is confined at that point, preventing further movement of the ball and thus preventing the cavity from connecting to the outlet pipe. When an air difference is created between the cavity and the outside, the liquid level drops to the connection point, and the steel ball, ready to move, descends with the liquid level, connecting the cavity to the outlet pipe. This design is simple and eliminates the need for the user to constantly monitor the liquid level.

[0050] The return tube can also be spiral, straight, or other shapes. In this embodiment of the invention, the use of a U-shaped tube can prevent air from entering and disrupting the vacuum environment, and also allows for large-scale mixing of the liquid as it passes through the narrow tube, resulting in better mixing compared to other shapes. Preferably, the U-shaped tube is vertically inverted and communicates with the cavity.

[0051] Preferably, the step of pressurizing the outflowing liquid by changing the cross-sectional area of ​​the outlet pipe using a pressure rod includes:

[0052] The pressure rod, which has a trapezoidal or conical top, is moved by a pressure applying mechanism to change the cross-sectional area of ​​the outlet pipe and pressurize the outflowing liquid. The pressure applying mechanism can be one or more of hydraulic, pneumatic, electrical, or mechanical.

[0053] In this embodiment of the invention, the top of the pressure rod is set to be trapezoidal or conical. Compared with the conventional cylindrical or rectangular shape, it can change the cross-sectional area more quickly when the same pressure is applied; or when moving the same distance, the cross-sectional area of ​​a certain section of the liquid outlet changes more, and the liquid flow rate is faster at this point, so as to achieve uniform mixing of liquid in a small-scale area.

[0054] Preferably, the liquid in the cavity is controlled by the three-way valve to either circulate or pressurize.

[0055] In a three-way valve, the pipes are connected to the cavity, the return pipe, and the outlet pipe respectively. The valve core controls the opening and closing of the pipes to achieve control, execution of cyclic or pressurization operations.

[0056] Preferably, the cycle and the pressurization operation alternate twice.

[0057] Performing the circulation and pressurization operations twice each is sufficient to meet the mixing requirements for preparing clonidine. If a better mixing effect is desired, the operations can be performed alternately multiple times, but this would waste manpower and resources, and the mixing uniformity would not be significantly improved. Therefore, in this embodiment of the invention, the number of alternations is set to two.

[0058] Preferably, the pressure is controlled between 6-8 MPa, the maximum flow rate is 900 m / s, and the prepared clonidine colloid is less than 20000 cp.

[0059] This design does not damage the molecular structure and results in better mixing.

[0060] Preferably, the diameter of the cavity is less than twice the diameter of the steel ball;

[0061] The size of the steel ball is such that when the steel ball is at its maximum height in the cavity, it is tangent to the upper edge of the cavity and the edge near the small hole, respectively, thus just blocking the small hole.

[0062] Preferably, the diameter of the communication hole between the cavity and the liquid inlet pipe is smaller than the diameter of the steel ball;

[0063] The size of the steel ball is such that when the steel ball is at its minimum height in the cavity, it is tangent to the left and right sides of the cavity, respectively, and just blocks the connection hole between the cavity and the liquid inlet pipe.

[0064] Example 2

[0065] This invention provides a mixed liquid system for producing colloidal colloids, comprising:

[0066] The feeding module is used to place the liquids to be mixed in the same container, and the motor drives the drive rod to move so that the liquid flows into the cavity;

[0067] The circulation module is used to control the liquid flow out and return it to the container based on the cooperation between the drive rod and the steel ball in the cavity;

[0068] The pressurization module is used to recirculate the liquid into the cavity and pressurize the outflowing liquid by changing the cross-sectional area of ​​the outlet pipe through the pressure rod.

[0069] A mixing module is used to alternately execute the circulation module and the pressurization module to form a uniformly mixed liquid.

[0070] Preferably, the discharge module is used to drive the drive rod downward to extend out of the cavity via the motor, so that liquid flows into the cavity according to the pressure difference, and the steel ball moves to the small hole connecting the cavity and the liquid outlet pipe.

[0071] Preferably, the circulation module is used to extend upward into the cavity via the drive rod, generate an impact force to move the position of the steel ball, so that the cavity is connected to the outlet pipe, and the liquid returns to the container through the U-shaped return pipe.

[0072] Preferably, the pressurization module is used to pressurize the outflowing liquid by moving a pressure rod with a trapezoidal or conical top using a pressurizing mechanism to change the cross-sectional area of ​​the outlet pipe, wherein the pressurizing mechanism is one or more of hydraulic, pneumatic, electrical or mechanical.

[0073] Preferably, the mixing module controls the liquid in the cavity to either operate as a circulation module or a pressurization module according to the three-way valve.

[0074] The specific embodiments described above further illustrate the purpose, technical solution, and beneficial effects of the present invention. It should be understood that the above description is only a specific embodiment of the present invention and is not intended to limit the scope of protection of the present invention. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the scope of protection of the present invention.

Claims

1. A method for making a cocktail of colloclonidine, characterized in that, The method comprises: putting the liquid to be mixed into the same container, driving the driving rod to move by the motor to make the liquid flow into the cavity; circulating, controlling the liquid to flow out and return to the container according to the cooperation between the driving rod and the steel ball in the cavity; pressurizing, making the liquid flow into the cavity again after circulation, changing the cross-sectional area of the liquid outlet pipe by the pressure rod to pressurize the liquid flowing out, wherein the pressure value is controlled between 6-8MPa, the maximum flow rate is 900m / s, and the prepared colloid of clonidine is less than 20000cp; and alternately performing the circulation and the pressurizing to form a uniformly mixed liquid.

2. The method for preparing a mixed liquid for producing colloidal colloid according to claim 1, characterized in that, The method comprises: extending the driving rod out of the cavity downward by the motor, making the liquid flow into the cavity according to the pressure difference, and moving the steel ball to the small hole where the cavity and the liquid outlet pipe are connected.

3. The method for preparing a mixed liquid for producing colloidal colloid according to claim 1, characterized in that, The method comprises: extending the driving rod into the cavity upward, generating an impact force to move the position of the steel ball, making the cavity and the liquid outlet pipe connected, and returning to the container through the U-shaped return pipe.

4. The method for preparing a mixed liquid for producing colloidal colloid according to claim 1, characterized in that, The method comprises: moving the pressure rod with a top trapezoidal or conical shape by the pressure applying mechanism to change the cross-sectional area of the liquid outlet pipe and pressurize the liquid flowing out, wherein the pressure applying mechanism is one or more of hydraulic, pneumatic, electrical or mechanical.

5. The method of claim 1, wherein the mixture of liquids is prepared by mixing a solution of a salt of a weak acid and a salt of a weak base. 5 controlling the liquid in the cavity to perform one of the circulation or the pressurizing according to the three-way valve.

6. The method of claim 1, wherein the mixture of liquids is prepared by mixing a solution of a salt of a polymeric anion and a solution of a salt of a polymeric cation. The circulation and the pressurizing operation appear alternately twice.

7. The method of claim 2, wherein the mixture of liquids is prepared by mixing a solution of a salt of clonidine with a solution of a polymer. The diameter of the cavity is less than twice the diameter of the steel ball. The size of the steel ball is that when the steel ball is at the maximum height in the cavity, the steel ball is tangent to the upper edge of the cavity and the edge close to the small hole, and the small hole is just blocked.

8. The method of claim 2, wherein the mixture of liquids is prepared by mixing a solution of a salt of clonidine with a solution of a polymer. The diameter of the communication hole between the cavity and the liquid inlet pipe is less than the diameter of the steel ball. The size of the steel ball is that when the steel ball is at the minimum height in the cavity, the steel ball is tangent to the left edge and the right edge of the cavity, and the communication hole between the cavity and the liquid inlet pipe is just blocked.

Images