Biological sensor

Abstract

One aspect of the present invention relates to a biosensor (1) having: a fixing member (20) having an annular frame (21); and a first strain sensor element (31) and a second strain sensor element (32) that are filamentary or strip-shaped and extendable along the length direction, the first strain sensor element (31) and the second strain sensor element (32) being mounted on the frame (21) in an intersecting manner, the frame (21) being configured to deform at least in the length direction of the first strain sensor element (31) and the length direction of the second strain sensor element (32).

Description

Technical Field

[0001] This invention relates to a biosensor. Background Technology

[0002] Various attempts have been made to detect and quantify the movements of subjects such as humans and animals using sensors.

[0003] As a device for detecting the movement of these objects, strain sensor elements that use a strain sensor element whose resistance changes in response to stretching are known (for example, see International Publication No. 2019 / 031381). By using the strain sensor element for movement detection, a non-invasive sensor with excellent wearability can be constructed.

[0004] Patent Document 1: International Publication No. 2019 / 031381 Summary of the Invention

[0005] A strain sensor element is filamentary or strip-shaped and can detect the movement of a measured object by the change in resistance caused by its stretching or contraction along its length. When the strain sensor element is worn on the measured object at its natural length, if the measured object moves in the direction that causes the strain sensor element to stretch (hereinafter referred to as the "stretching direction"), the strain sensor element stretches due to this stretching, causing a change in resistance, thus enabling the detection of the measured object's movement. Conversely, if the measured object moves in the direction that causes the strain sensor element to shorten (hereinafter referred to as the "shortening direction"), since the strain sensor element is worn at its natural length, the strain sensor will only sag and will not shorten. That is, since the strain sensor does not experience a change in resistance, it is impossible to detect the movement of the measured object.

[0006] To enable the detection of the object's movement even when it moves in the shortening direction, conventional strain sensors pre-stress the strain sensor element, that is, they are worn on the object in a stretched state. In this case, even if the object moves in the shortening direction, the strain sensor element shortens back to its natural length, thus generating a change in resistance and enabling the detection of the object's movement.

[0007] If the prestress is insufficient, the strain sensor element will loosen, thus preventing the detection of movement in the shortening direction. On the other hand, if the prestress is excessive, a range-over error may occur on the measurement circuit side when the object being measured moves in the elongation direction, preventing measurement. Therefore, the prestress needs to be applied appropriately, and the installation of the strain sensor element requires considerable effort.

[0008] The present invention was made in view of the above circumstances, and the objective is to provide a non-invasive biosensor that is comfortable to wear, easy to wear, and capable of detecting the shortening direction of the measured object.

[0009] One aspect of the present invention relates to a biosensor comprising: a fixing member having an annular frame; and a first strain sensor element and a second strain sensor element that are telescopic in a filamentary or strip-like manner along their length, the first strain sensor element and the second strain sensor element being mounted on the frame in an intersecting manner, the frame being configured to deform at least in the length direction of the first strain sensor element and the length direction of the second strain sensor element. Attached Figure Description

[0010] Figure 1 This is a schematic perspective view illustrating a biosensor according to one embodiment of the present invention.

[0011] Figure 2 yes Figure 1 A schematic side view of a biosensor.

[0012] Figure 3 It means and Figure 1 A schematic magnified top view of the vicinity of the frame of the biosensor involved in different implementations.

[0013] Figure 4 This indicates that the object being measured is not moving. Figure 1 A schematic magnified top view of the area near the frame of the biosensor.

[0014] Figure 5 This indicates the situation where the object being measured moves in the elongation direction of the first strain sensor element. Figure 1 A schematic magnified top view of the area near the frame of the biosensor.

[0015] Figure 6 This indicates the case where the object being measured moves in the shortening direction of the first strain sensor element. Figure 1 A schematic magnified top view of the area near the frame of the biosensor.

[0016] Figure 7 It means and Figure 1 and Figure 3 A schematic magnified top view of the vicinity of the frame of the biosensor involved in different implementations. Detailed Implementation

[0017] One aspect of the present invention relates to a biosensor comprising: a fixing member having an annular frame; and a first strain sensor element and a second strain sensor element that are telescopic in a filamentary or strip-like manner along their length, the first strain sensor element and the second strain sensor element being mounted on the frame in an intersecting manner, the frame being configured to deform at least in the length direction of the first strain sensor element and the length direction of the second strain sensor element.

[0018] One aspect of the present invention relates to a biosensor that can be attached to the surface of a measurement object, such as a human body, making it non-invasive and comfortable to wear. Furthermore, when the measurement object moves in the elongation direction of the first strain sensor element, the biosensor can detect the movement of the measurement object via the first strain sensor element. Conversely, when the measurement object moves in the shortening direction of the first strain sensor element, the second strain sensor element, which intersects with the first strain sensor element, extends due to the deformation of the frame, thus enabling the detection of the movement of the measurement object via the second strain sensor element. In other words, this biosensor can detect movement of the measurement object not only in the elongation direction of the first strain sensor element but also in the shortening direction. Moreover, this biosensor does not require pre-stress during wear, making it easy to wear.

[0019] The first strain sensor element and the second strain sensor element can be orthogonal.

[0020] The intersection of the first strain sensor element and the second strain sensor element can be the center position of the frame.

[0021] The frame can be circular or polygonal.

[0022] The fixing component may have a rod-shaped or plate-shaped first reinforcing part and a second reinforcing part extending from the outer edge of the frame in opposite directions along the length direction of the first strain sensor element.

[0023] It may have: a strip-shaped substrate that is flexible for fixing the fixing member; and a rod-shaped or plate-shaped first holding portion and a second holding portion extending along the length direction of the first strain sensor element on the surface of the substrate, the first holding portion and the second holding portion being disposed outside the frame and separated from the frame along the length direction of the first strain sensor element.

[0024] Hereinafter, embodiments of the present invention will be described in detail with appropriate reference to the accompanying drawings.

[0025] Figure 1 and Figure 2 The biosensor 1 includes a substrate 10, a fixing component 20, a first strain sensor element 31 and a second strain sensor element 32, and a holding part 40. These structural elements can all be made relatively thin, therefore the biosensor 1 can also be made relatively thin as a whole.

[0026] The fixing component 20 has an annular frame 21, on which the first strain sensor element 31 and the second strain sensor element 32 are mounted in a cross-shaped manner. Additionally, the substrate 10 fixes the fixing component 20. This biosensor 1 is preferably used as a device for measuring human behavior, such as respiratory measurement.

[0027] <Substrate>

[0028] The substrate 10 is strip-shaped and flexible.

[0029] As the base material 10, it is preferable to have flexibility that does not hinder the stretching and contraction of the fixing component 20, for example, knitted fabric, textiles, non-woven fabric, rubber, leather, etc., among which highly stretchable knitted fabric is particularly preferred.

[0030] In this biosensor 1, such as Figure 2 As shown, a fixing member 20, a holding part 40, and wiring 33 (described later) are fixed to the surface of a substrate 10. Furthermore, in Figure 2 The diagram shows a structure in which a fixing member 20 is fixed to the surface of a substrate 10. However, it is preferable to have a structure in which another substrate 10 is stacked on the surface side of the substrate 10, and the fixing member 20 is fixed by the two substrates 10 sandwiching it. As described above, the wearing comfort can be improved by the fixing member 20 being sandwiched by the two substrates 10.

[0031] The substrate 10 is preferably hollowed out along the frame 21 of the fixing member 20, which will be described later. That is, the substrate 10 preferably has a hole 11 that overlaps with the frame 21 of the fixing member 20 when viewed from above. As described above, by providing the hole 11 in the substrate 10, there are no structures on the inner side of the ring of the fixing member 20 that would hinder the movement of the fixing member 20. Therefore, the movement of the object being measured can be easily concentrated on the first strain sensor element 31 and the second strain sensor element 32, thereby improving the sensitivity of the biosensor 1.

[0032] The size of the substrate 10 is appropriately determined based on the size of the fixing component 20, etc. For example, it can be 5cm or more but less than 15cm in length and 2cm or more but less than 5cm in width. The size of the biosensor 1 when viewed from above is determined by the size of the substrate 10, but as mentioned above, it can also be set to be smaller.

[0033] Alternatively, an adhesive layer may be provided on the back side of the substrate 10 (the side without the fixing member 20, etc.). As described above, by providing an adhesive layer on the back side of the substrate 10, it can be easily adhered to or peeled off relative to the object being measured.

[0034] <Fixed components>

[0035] In addition to the frame 21, the fixing component 20 also includes... Figure 1 The image shows two rod-shaped or plate-shaped reinforcing portions 22 (first reinforcing portion 22a and second reinforcing portion 22b) extending in opposite directions from the outer edge of the frame 21 along the length direction of the first strain sensor element 31. The fixing member 20 is fixed to the substrate 10 as described above. The method of fixing the fixing member 20 is not particularly limited; for example, a method of bonding the entire surface of the fixing member 20 in contact with the substrate 10 to the substrate 10 can be cited.

[0036] (frame)

[0037] The frame 21 is configured to deform at least along the length direction of the first strain sensor element 31 and the length direction of the second strain sensor element 32. Figure 1 In the biosensor 1, the frame 21 is annular and can deform in any direction. As described above, by being able to deform in any direction, the movement of the object being measured can be easily captured even if, for example, the movement is not along the length direction of the first strain sensor element 31 or the length direction of the second strain sensor element 32. However, deformation in directions other than the length direction of the first strain sensor element 31 and the length direction of the second strain sensor element 32 is not necessary.

[0038] The material of the frame 21 and the thickness (width, diameter) of its rings are determined to give it elasticity that allows it to deform in response to the movement of the object being measured. For example, polyurethane rubber with a width of 0.5 mm to 1 mm or more, or elastic wire with a diameter of 0.1 mm to 1.0 mm or more, can be used. Examples of such elastic wires include hard steel wire, piano wire, stainless steel wire, and phosphor bronze for springs. Furthermore, it is preferable that the thickness of the rings in the frame 21 is uniform. By making the thickness of the rings in the frame 21 uniform, the first strain sensor element 31 and the second strain sensor element 32 can elongate proportionally to the movement of the object being measured, thus improving measurement accuracy.

[0039] The size of frame 21 (in) Figure 1 In the biosensor 1, the frame 21 is annular, and its outer diameter is appropriately determined accordingly with respect to the sensitivity of the first strain sensor element 31 and the second strain sensor element 32 mounted on the frame 21. For example, it can be more than 1 cm and less than 3 cm.

[0040] (Strengthening Department)

[0041] The reinforcing part 22 is a component used to accurately capture the movement of the measured object in the longitudinal direction of the first strain sensor element 31 and guide the deformation of the frame 21. For example, when the measured object is a human body and its movement is caused by breathing, the movements of the human body surface caused by breathing are not the same. If the movement of the human body surface can be captured at any location where the reinforcing part 22 is located by providing this reinforcing part 22, then the movement can be transmitted to the frame 21.

[0042] Two reinforcing parts 22, namely the first reinforcing part 22a and the second reinforcing part 22b, are symmetrically arranged across the frame 21. By improving the symmetry of the first strain sensor element 31 in the longitudinal direction, uneven deformation of the frame 21 caused by the movement of the object being measured is suppressed, thereby improving measurement accuracy. In addition, from the viewpoint of measurement accuracy, the first reinforcing part 22a and the second reinforcing part 22b can be configured to be aligned with the first strain sensor element 31.

[0043] The same material as the frame 21 can be used as the material for the reinforcement part 22.

[0044] The width and length of the reinforcing part 22 are appropriately optimized in relation to the object being measured. If the width and length of the reinforcing part 22 are too short, the movement of the object being measured may not be accurately captured. Conversely, if the width and length of the reinforcing part 22 are too long, it will be difficult to cause the reinforcing part 22 to move due to the movement of the object being measured, and the deformation of the frame 21 will decrease, thus potentially reducing the measurement sensitivity.

[0045] Furthermore, from the viewpoint of measuring sensitivity, the reinforcing part 22 is preferably arranged parallel to the longitudinal direction of the first strain sensor element 31, but this does not preclude the possibility of it being arranged at an angle to the longitudinal direction of the first strain sensor element 31. The biosensor 1 can achieve the same effect even when arranged at an angle to the longitudinal direction of the first strain sensor element 31. Moreover, the angle between the reinforcing part 22 and the longitudinal direction of the first strain sensor element 31 is, for example, set to 30 degrees or less, and the smaller the better.

[0046] <Strain Sensor>

[0047] The first strain sensor element 31 and the second strain sensor element 32 (hereinafter collectively referred to as "strain sensor elements") are filamentary or strip-shaped components that stretch along their length. The strain sensor elements can directly detect the movement of the object being measured. For example, in the case of measuring human respiration, changes in the respiratory state can be detected in real time, thus enabling the acquisition of predictive data for certain respiratory diseases, such as respiratory failure, without delay.

[0048] The strain sensor element can be any element that is stretchable and whose electrical characteristics change accordingly with stretching; preferably, a strain resistance element whose resistance changes with stretching is used. Among these, CNT strain sensors using carbon nanotubes (hereinafter also referred to as "CNTs") are particularly preferred as the strain sensor element.

[0049] When the strain sensor element is filamentous, it can be constructed by comprising CNT bundles. These CNT bundles are fiber bundles in which multiple CNTs (monofibers) are oriented approximately along the length of the CNT element and covered with resin. The filamentous strain sensor element, from its radial center outwards, sequentially comprises a conductive portion composed of CNT bundles, a conductive layer obtained by combining CNT fibers and resin, and a resin-based covering film. The strain sensor element can generate a change in resistance by the breakage of the central CNT bundle, with the interval between these breaks varying.

[0050] On the other hand, when the strain sensor element is strip-shaped, it can be made of a resin composition containing a large number of CNT fibers. Specifically, the strip-shaped strain sensor element has a sheet of multiple fiber bundles in which multiple CNTs (monofibers) are oriented approximately along the length of the CNT element, and a resin covering the sheet of these fiber bundles. When an elongation strain is applied to the strain sensor element, the internal CNT fibers are cut and the ends of the CNTs separate, or the elongation strain is relieved and they re-engage, thereby causing a change in resistance.

[0051] As the CNT, either single-walled carbon nanotubes (SWNTs) or multi-walled carbon nanotubes (MWNTs) can be used. Among them, MWNTs are preferred from the viewpoint of electrical conductivity and heat capacity, and MWNTs with a diameter of 1.5 nm or more and 100 nm or less are more preferred.

[0052] The CNTs can be manufactured using known methods, such as CVD, arc flash, laser ablation, DIPS, and CoMoCAT. Among these, CVD using iron as a catalyst and ethylene gas is preferred for efficiently obtaining CNTs (MWNTs) of the desired size. In this case, an iron or nickel thin film serving as a catalyst is formed on a substrate such as a quartz glass substrate or a silicon substrate with an oxide film, and CNTs of the desired length are grown vertically oriented on this film.

[0053] The two ends of the first strain sensor element 31 and the second strain sensor element 32 are connected to a measuring unit (not shown) that measures resistance changes via wiring 33. Furthermore, wiring 33 is connected in a manner that allows independent measurement of the resistance changes of the first strain sensor element 31 and the second strain sensor element 32.

[0054] Preferably, the first strain sensor element 31 and the second strain sensor element 32 are orthogonal, that is, the length direction of the first strain sensor element 31 and the length direction of the second strain sensor element 32 are orthogonal. Even if the length direction of the first strain sensor element 31 and the length direction of the second strain sensor element 32 are not orthogonal, the biosensor 1 can achieve the same effect, but by making them orthogonal, the sensitivity of measuring the shortening direction of the first strain sensor element 31 is particularly improved.

[0055] On the other hand, the length direction of the first strain sensor element 31 and the length direction of the second strain sensor element 32 do not necessarily have to intersect. Figure 3 The biosensor 2 shown illustrates a structure where the longitudinal directions of the first strain sensor element 31 and the second strain sensor element 32 do not intersect. In this case, the extended lines of the longitudinal directions of the first strain sensor element 31 and the second strain sensor element 32 are configured to intersect. Furthermore, Figure 3 The biosensor 2 has two sets of first strain sensor elements 31 and second strain sensor elements 32. As described above, the biosensor 2 may also be configured to have multiple sets of first strain sensor elements 31 and second strain sensor elements 32.

[0056] The intersection of the first strain sensor element 31 and the second strain sensor element 32 can be any position within the frame 21, but is preferably at the center of the frame 21. That is, in the case of a circular frame 21, it is preferable to set the intersection of the first strain sensor element 31 and the second strain sensor element 32 at the center of the circle. As described above, setting the intersection at the center of the frame 21 improves the measurement sensitivity. Furthermore, the first strain sensor element 31 and the second strain sensor element 32 are not connected at this intersection. That is, the first strain sensor element 31 and the second strain sensor element 32 are configured to operate independently.

[0057] <Maintenance Section>

[0058] The holding portion 40 is composed of two parts: a first holding portion 40a and a second holding portion 40b. The two holding portions 40 (the first holding portion 40a and the second holding portion 40b) are rod-shaped or plate-shaped and extend along the length of the first strain sensor element 31 on the surface of the substrate 10. These two holding portions 40 are arranged outside the frame 21, facing each other along the length of the second strain sensor element 32, separated by the frame 21.

[0059] The retaining part 40 suppresses the situation where the substrate 10 moves along the length direction of the first strain sensor element 31 when the measuring object moves, for example, by bending, and the movement of the measuring object is not sufficiently transmitted to the frame 21.

[0060] The same material as the frame 21 can be used for the retaining part 40. In addition, the width, length and distance of the retaining part 40 from the frame 21 are appropriately determined in a way that the motion of the measuring object is effectively transmitted to the frame 21.

[0061] <Principles of Movement>

[0062] This biosensor 1 can detect the elongation and shortening directions of the object being measured relative to the first strain sensor element 31 without applying prestress to the first strain sensor element 31 and the second strain sensor element 32. Hereinafter, using... Figures 4 to 6 The working principle of its operation is explained.

[0063] Figure 4 This is a diagram showing the area around the frame 21 of the biosensor 1 when the object being measured is not moving. When the object being measured is not moving, the frame 21 is an annular shape used to maintain its original shape.

[0064] Figure 5The diagram illustrates the case where the object being measured moves along the elongation direction of the first strain sensor element 31. If the object moves along the elongation direction of the first strain sensor element 31, the frame 21 deforms into an elliptical ring with the length direction of the first strain sensor element 31 as its major axis. In this case, the first strain sensor element 31 is elongated, thus generating a change in resistance. On the other hand, the second strain sensor element 32 is not subjected to prestress, and therefore relaxes due to the change in the frame 21, without generating a change in resistance. Based on the above, when the object being measured moves in the elongation direction of the first strain sensor element 31, this movement can be detected based on the change in resistance of the first strain sensor element 31.

[0065] In contrast, Figure 6 The diagram illustrates the case where the object being measured moves in the shortening direction of the first strain sensor element 31. If the object moves in this direction, the frame 21 deforms into an elliptical ring with the length direction of the second strain sensor element 32 as its major axis. In this case, the first strain sensor element 31 is not subjected to prestress, and therefore relaxes due to the change in the frame 21, resulting in no change in resistance. Conversely, the second strain sensor element 32 is stretched, thereby generating a change in resistance. Based on the above, when the object being measured moves in the shortening direction of the first strain sensor element 31, this movement can be detected based on the change in resistance of the second strain sensor element 32.

[0066] As described above, in this biosensor 1, even if the object being measured moves in any direction, either the elongation direction or the shortening direction, the movement can be detected by the resistance change of the first strain sensor element 31 or the resistance change of the second strain sensor element 32.

[0067] Furthermore, the above description only addressed the case where no prestress was applied to the first strain sensor element 31 and the second strain sensor element 32; however, they function equally well even when prestress is applied. Therefore, the case where prestress is applied to the first strain sensor element 31 and the second strain sensor element 32 is not explicitly described. However, it is preferable not to apply prestress that would cause deformation of the frame 21.

[0068] <Advantages>

[0069] This biosensor 1 can be attached to the surface of a measurement object, such as a human body, making it non-invasive and comfortable to wear. Furthermore, when the measurement object moves in the elongation direction of the first strain sensor element 31, the biosensor 1 can detect the movement of the measurement object via the first strain sensor element 31. Conversely, when the measurement object moves in the shortening direction of the first strain sensor element 31, the second strain sensor element 32, which intersects with the first strain sensor element 31, extends due to the deformation of the frame 21, thus allowing the movement of the measurement object to be detected via the second strain sensor element 32. In other words, this biosensor 1 can detect not only the movement of the measurement object in the elongation direction of the first strain sensor element 31 but also its movement in the shortening direction. Moreover, this biosensor 1 does not require pre-stress during wear, making it easy to wear.

[0070] [Other Implementation Methods]

[0071] The embodiments described do not limit the structure of the present invention. Therefore, the structural elements of each part of the embodiments can be omitted, replaced, or added based on the description in this specification and common technical knowledge, and should be interpreted as all of them falling within the scope of the present invention.

[0072] In the described embodiment, the case where the fixing component has two reinforcing parts was explained; however, there may be one or more reinforcing parts. These reinforcing parts are not essential structural elements. When the movement of the object being measured is captured solely by the frame, the reinforcing parts may be omitted.

[0073] In the described embodiment, the biosensor has two holding portions; however, it may also have one or more holding portions. Furthermore, the holding portion is not a necessary structural element and may be omitted. In a biosensor without a holding portion, the substrate may also be omitted. The biosensor of the present invention can achieve the same effect even without a holding portion or substrate.

[0074] In the described embodiment, the case where the frame is annular was explained. Other shapes can be used as long as the structure is capable of deformation at least in the length directions of the first strain sensor element and the second strain sensor element. A polygonal annular shape is an example of such a frame shape. Figure 7 In the biosensor 3 shown, the frame 23 is a rhomboid ring, one of the polygonal ring shapes.

[0075] In the case of such a polygonal ring-shaped frame 23, it is preferable that the length directions of the first strain sensor element 31 and the second strain sensor element 32 are part of the diagonals of the frame 23. In the case of a rhomboid frame 23, the length directions of the first strain sensor element 31 and the second strain sensor element 32 form the two diagonals of the rhombus. If configured as described above, deformation will also occur in the length direction of the second strain sensor element 32 due to the expansion and contraction of the first strain sensor element 31.

[0076] Furthermore, the frame 23 is rhomboid, so that the first strain sensor element 31 and the second strain sensor element 32 are orthogonal, and their intersection point is the center of the frame 23. By adopting such a structure, the measurement accuracy and sensitivity of the biosensor 3 can be improved.

[0077] Industrial applicability

[0078] As described above, the biosensor of the present invention is non-invasive and has excellent wearability, making it easy to wear and capable of detecting the shortening movement of the measured object.

[0079] Explanation of the label

[0080] 1, 2, 3 Biosensors

[0081] 10 Substrate

[0082] 11 holes

[0083] 20 Fixed components

[0084] Frames 21 and 23

[0085] 22 Strengthening Department

[0086] 22a First Reinforcement Section

[0087] 22b Second Reinforcement Section

[0088] 31 First strain sensor element

[0089] 32. Second strain sensor element

[0090] 33 Wiring

[0091] 40. Holding section

[0092] 40a First Holding Section

[0093] 40b Second Retention Section

Claims

1. A biosensor, comprising: A fixing component having a ring-shaped frame; and The first and second strain sensor elements are filamentous or strip-shaped and extendable along their length. The first strain sensor element and the second strain sensor element are mounted on the frame in a cross-shaped manner. The frame is configured to deform at least in the longitudinal direction of the first strain sensor element and the longitudinal direction of the second strain sensor element. The first strain sensor element and the second strain sensor element are not connected at their intersection, and the first strain sensor element and the second strain sensor element operate independently.

2. The biosensor according to claim 1, wherein, The first strain sensor element and the second strain sensor element are orthogonal.

3. The biosensor according to claim 1 or 2, wherein, The intersection of the first strain sensor element and the second strain sensor element is the center position of the frame.

4. The biosensor according to claim 1 or 2, wherein, The frame is circular or polygonal.

5. The biosensor according to claim 1 or 2, wherein, The fixing component has a rod-shaped or plate-shaped first reinforcing part and a second reinforcing part that extend along the length direction of the first strain sensor element from the outer edge of the frame in opposite directions.

6. The biosensor according to claim 1 or 2, wherein, The sensor has the following characteristics: A strip-shaped substrate, which is flexible, is used to fix the fixing component; and A rod-shaped or plate-shaped first and second retaining portions extending along the length direction of the first strain sensor element on the surface of the substrate. The first and second retaining portions are arranged along the length of the first strain sensor element, on the outside of the frame, separated by the frame.

7. The biosensor according to claim 1, wherein, The biosensor also has: The first flexible substrate is configured to be able to be adhered to or peeled off relative to the test object. The first reinforcing part is disposed on the first flexible substrate, connected to the frame, and extends from the frame along a first direction. The second reinforcing part is disposed on the first flexible substrate, connected to the frame, and extends from the frame in a second direction opposite to the first direction. The first reinforcing part and the second reinforcing part are configured to be in a straight line with the first strain sensor element.

8. The biosensor according to claim 1, wherein, If the object being measured moves along the third direction, the first strain sensor element extends along its length. The movement of the object along the third direction can be detected based on the change in resistance of the first strain sensor element caused by its extension along its length. The third direction is the direction along the length of the first strain sensor element. On the other hand, if the object being measured moves along a fourth direction different from the third direction, the second strain sensor element extends along its length. The movement of the object being measured along the fourth direction can be detected based on the change in resistance of the second strain sensor element caused by its extension along its length. The fourth direction is the direction along the length of the second strain sensor element.

9. A biosensor, comprising: A fixing component having a ring-shaped frame; The substrate, on which the fixing component is fixed, has a hole that overlaps with the frame of the fixing component when viewed from above; as well as The first and second strain sensor elements are filamentous or strip-shaped and extendable along their length. The first strain sensor element and the second strain sensor element are mounted on the frame in a cross-shaped manner. The first strain sensor element and the second strain sensor element are not connected at their intersection point, and each of the first strain sensor element and the second strain sensor element operates independently. The frame is configured to deform at least in the length direction of the first strain sensor element and the length direction of the second strain sensor element.

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