Sprayer and Cartridge

Abstract

A nebulizer for atomizing a fluid from a cartridge and a cartridge for such a nebulizer are provided. The cartridge includes a container that houses the fluid to be atomized and is fluidly connected to the nebulizer by inserting a connecting element of the nebulizer to deliver the fluid out of the container. The cartridge is preferably adapted to receive the connecting element in a sealed manner and may optionally include a diaphragm or a sealing wall that initially seals the cartridge and is capable of being pierced or broken by the connecting element when the connecting element is inserted. The cartridge may further include at least partially flexible and / or bendable tubing for delivering the fluid out of the container. The tubing is preferably wettable by the fluid and / or includes at least partially hydrophilic and / or polar surfaces. Additionally, the tubing may be at least partially shaped in a helical shape. When the cartridge is connected to the nebulizer, the tubing and the connecting element preferably form a continuous capillary and / or at least substantially constant flow area.

Description

[0001] This application is a divisional application of the patent application with the application number 201780079860.0, the invention title "Sprayer and Cartridge", and the filing date December 21, 2017. This application relates to a sprayer cartridge according to the description and a sprayer according to the description.

[0002] WO 2009 / 047173 A2 discloses a sprayer for atomizing a fluid. The sprayer includes an insertable cartridge for containing the fluid, a housing for containing the cartridge, and a pressure generator with a drive spring for pressurizing a defined dose of the fluid to be atomized. The sprayer further includes a delivery tube that can be inserted into the cartridge and withdraws a defined dose of the fluid from the cartridge when the drive spring is tensioned.

[0003] WO 2009 / 103510 A1 discloses a sprayer that includes a pre-inserted cartridge that contains the fluid to be atomized. The cartridge includes a flexible delivery tube for delivering the fluid out of the cartridge.

[0004] WO 2010 / 094305 A1 discloses a sprayer for dispensing a liquid, wherein the sprayer includes a cartridge that has a storage device for containing the liquid and a pressurized gas that pushes the liquid through a valve out of the storage device to dispense the liquid.

[0005] WO 2012 / 130757 A1 relates to a handheld device, in particular an atomizer, for discharging a liquid pharmaceutical preparation from a container having a container lid. The pharmaceutical preparation can be, for example, alcohol-solvent-based. The atomizer having an insert into the container includes a sealing system that consists of two seals at the connection location between the device and the container, and the sealing system prevents liquid loss, diffusion leakage, and gas exchange with the gas around this location.

[0006] Depending on the spatial orientation of these sprayers / cartridges, the withdrawal of the fluid is affected. Specifically, it may happen that not enough fluid can be withdrawn from the cartridge, and / or gas or air may be sucked in, and / or not the entire volume is exhausted, such that after the last dose delivery, a residual amount of fluid remains in the cartridge.

[0007] WO 98 / 46522A1 discloses a cartridge having a fluid and a storage medium (such as a sponge). The end of a rigid or flexible tube for withdrawing the fluid is located in the storage medium, which can be firmly attached to the cartridge wall or swing freely together with the withdrawal tube. The storage medium always holds a certain amount of fluid, even when the end of the tube is above the liquid level in the cartridge. In this way, the fluid can be withdrawn from the cartridge with substantially no influence from its spatial orientation. However, there will still be a certain residual amount of fluid left in the cartridge or the storage medium that cannot be removed.

[0008] US 5,527,577 A discloses a liquid dispenser having a flexible outlet tube for discharging a liquid product from a container. The tube comprises a combination of a flexible material and a dense filling material to provide a specific gravity greater than that of the liquid product, so that when the container is tilted from a vertical orientation, the inlet orifice of the outlet tube can be kept below the level of the liquid product. In an alternative embodiment, the outlet tube comprises a layer having an absorbent material which can absorb a small portion of the liquid product to reduce or eliminate the surface tension between the outlet tube and the liquid product and reduce the tendency of the outlet tube to float on the liquid.

[0009] DE 103 47 466 A1 and FR 2 700 483 A1 disclose liquid dispensers having a dispensing mechanism which comprises a flexible outlet tube that carries a weight or ballast at its free end. When the liquid dispenser is inverted, the weight or ballast exerts a force on the tube due to gravity, causing the tube to bend so that the free end remains immersed in the liquid.

[0010] In view of the above, an object of the present invention is to provide an improved nebulizer which comprises a cartridge for the nebulizer and / or an improved cartridge, preferably, wherein the extraction / suction of the fluid contained in the cartridge is facilitated and / or can be carried out at least substantially independently of the spatial orientation of the nebulizer / cartridge, and / or wherein the amount of fluid that can be extracted from the cartridge is increased and / or the flow losses are reduced.

[0011] The above object is achieved by the cartridge or nebulizer of the present invention and its preferred embodiments.

[0012] The present invention relates to a nebulizer / dispensing device for atomizing / dispensing a fluid from a preferably replaceable cartridge containing the fluid, preferably a liquid, in particular a liquid pharmaceutical composition / formulation and / or a liquid medicament, and also relates to a cartridge for such a nebulizer / dispensing device.

[0013] The fluid is preferably polar and / or comprises an electric dipole moment.

[0014] Most preferably, the fluid is aqueous and / or contains an aqueous solution and / or water as a solvent.

[0015] Optionally, the fluid comprises an alcohol solution and / or an alcohol, in particular ethanol, as a solvent.

[0016] The cartridge preferably comprises a container and / or a bag which contains the fluid to be atomized / dispensed, in particular a multi-dose fluid.

[0017] Preferably, the cartridge comprises a tube, in particular a suction / delivery tube, more preferably a capillary tube, for delivering / withdrawing fluid from a container, preferably, wherein the tube is at least partially flexible or bendable.

[0018] According to one aspect of the invention, the tube (in particular its inner surface and / or outer surface) can be wetted by the fluid, preferably such that the tube (in particular at least its free end) is automatically wetted by a fluid film and / or automatically sucks in fluid and / or is ballasted by the fluid and / or automatically aligns / bends towards the fluid in the container and / or is at least partially immersed in the fluid once it comes into contact with the fluid.

[0019] Preferably, the tube is wettable and configured as a capillary tube, preferably with an inner diameter less than 1 mm or less than 0.8 mm, in particular less than 0.7 mm or less than 0.5 mm, in particular such that (preferably in the delivery state of the cartridge and / or when the cartridge is opened) the liquid level inside the tube is equal to or higher than the liquid level outside the tube, and / or such that (when the tube comes into contact with the fluid) the outer surface of the tube (in particular at least its free end) is wetted and further such that the tube sucks in / fills with fluid due to capillary action. Thus, in a synergistic manner, the tube is wetted and / or ballasted by the fluid on both its inner and outer surfaces.

[0020] Preferably, the tube (in particular its inner surface and / or outer surface) can be wetted by the fluid such that the contact angle between the fluid droplet and the tube surface is less than 70° or 60°, in particular less than 50° or 30°, most preferably less than 20°.

[0021] Preferably, the surface energy of the tube (in particular the surface energy of its inner surface and / or outer surface) is greater than or equal to the surface tension of the fluid. Most preferably, the surface energy of the tube, in particular the surface energy of its inner surface and / or outer surface, is at least 2 mN / m or 5 mN / m, in particular 8 mN / m or 10 mN / m greater than the surface tension of the fluid. In this way, good wetting of the tube can be achieved.

[0022] According to a preferred embodiment, the tube comprises at least partially a hydrophilic and / or polar surface, wherein the fluid is aqueous and / or comprises an aqueous solution and / or water as a solvent, or wherein the fluid comprises an alcohol solution and / or alcohol (such as ethanol) as a solvent. Thus, when the tube comes into contact with the fluid, the fluid widely wets the tube, in particular its hydrophilic and / or polar surface, with a fluid film.

[0023] Due to its wettability, the tube is ballasted by the fluid and / or automatically aligns / bends towards the fluid in the container once it comes into contact with and is wetted by the fluid, even if the fluid changes its position in the container, for example when the cartridge is in a horizontal position and / or inverted. As described above, this effect can be further enhanced by configuring the tube as a capillary tube, thereby automatically filling the tube with fluid.

[0024] Due to the (good) adhesion of the fluid to the tube surface (i.e., the force that causes the fluid to adhere to the tube surface) and / or due to the cohesion of the fluid molecules (i.e., the force that causes the fluid molecules to adhere to each other), at least the free end of the tube remains in the fluid.

[0025] In particular, the adhesion and cohesion are greater than the restoring force of the tube caused by bending, such that the tube does not return to its rest position but remains immersed in the fluid, even when changing the spatial orientation of the cartridge. In other words, the tube or at least its axial end automatically moves with the fluid within the cartridge and / or always remains in contact with the fluid. This allows the extraction of the fluid to be at least substantially unaffected by the spatial orientation of the cartridge.

[0026] Thus, the present invention allows the extraction of fluid and / or the tensioning and / or actuation of the nebulizer to be at least substantially unaffected by the spatial orientation of the cartridge. Specifically, the patient (i.e., the user of the nebulizer) does not have to ensure that the nebulizer is oriented in a specific spatial orientation, such as being vertically oriented, when tensioning and / or actuating the nebulizer. In this way, improper use or incorrect administration of the nebulizer can be prevented, or at least the risk of such improper use or incorrect administration can be reduced.

[0027] Preferably, for any spatial orientation, the immersion of the tube causes the free end of the tube to (always) be at least substantially located at or adjacent to the lowest point of the fluid in the cartridge.

[0028] Due to wettability and / or capillary action, the volume that can be extracted from the cartridge and / or the usage period of the cartridge can be increased.

[0029] Existing cartridges are typically filled with the fluid to be atomized to ensure a constant volume delivery of the dose, at least for the total planned administration. With the present invention, it is not necessary to significantly overfill the cartridge because almost the entire capacity of a normally filled cartridge can be utilized.

[0030] Wettability is preferably the ability of a material / surface (especially a solid surface) to be wetted and / or to remain in contact with a fluid (especially a liquid). It depends on the type of fluid and the type of material / surface used. In particular, wettability depends on the surface tension of the fluid, the surface energy of the material / surface, and the surface tension (interface energy) between the fluid and the surface. The wettability of a material / surface can be quantified by the contact angle, i.e., the angle formed between a fluid droplet and the (solid) surface / material under discussion.

[0031] The wettability / surface energy of a material / surface is preferably measured in accordance with DIN 55660-2:2011-12.

[0032] Preferably, if the contact angle is less than 90°, especially less than 70°, and / or if the surface energy of the material / surface (especially at least 2 mN / m or 5 mN / m) is greater than or equal to the surface tension of the fluid, the material / surface is considered to be wettable by the fluid.

[0033] The contact angle is preferably the angle formed between a fluid droplet on the material surface (i.e., the tangent at the contact point) and the material surface. The contact angle depends on the surface tension of the fluid, the surface energy of the material / surface, and the surface tension (interface energy) between the fluid and the material / surface. The contact angle is a measure of the wettability of the surface / material. A small contact angle (e.g., less than 70°) corresponds to high wettability, while a large contact angle (e.g., greater than 70° or 90°) corresponds to low wettability or non-wettability / non-wetting, often referred to as the pearl effect or lotus effect.

[0034] The contact angle Θ can be defined as (Young's equation):

[0035] cos(Θ) = [σ S – σ SF / σ F ,

[0036] where σ S is the surface energy of the (solid) material / surface, σ SF is the surface tension (interface energy) between the fluid and the material / surface, and σ F is the surface tension of the fluid measured in [N / m].

[0037] The contact angle is preferably measured according to DIN 55660-2:2011-12 and / or according to ISO 15989:2004-12.

[0038] The surface tension of the fluid is caused by the cohesive forces of the fluid. The surface tension causes the fluid surface to acquire the smallest possible surface area. The surface tension of the fluid is preferably measured according to DIN 55660-3:2011-12.

[0039] The surface tension of a solid material, also known as surface energy, is a measure of the energy required to break the intermolecular bonds of the material. Materials with a high surface energy are more easily wetted than materials with a low surface energy. The surface energy of a solid material is preferably measured according to DIN 55660-2:2011-12.

[0040] In particular, if the surface energy of the surface (preferably at least 2 mN / m or at least 5 mN / m) is higher than the surface tension of the fluid, the surface can be (completely) wetted by the fluid.

[0041] To obtain the desired properties of the tube, namely to increase its surface energy and / or wettability, the tube is preferably subjected to a surface treatment, in particular corona, plasma, flame, wet chemical treatment and / or (film) coating. These surface treatment methods are well known to those skilled in the art.

[0042] Additionally or alternatively, the tube preferably contains at least one additive to increase its surface energy.

[0043] Preferably, the tube is made of rubber, in particular butyl rubber, and / or made of (flexible) plastic, in particular thermoplastic and / or thermoplastic elastomer, such as polyamide, polyethylene, polypropylene, polybutylene terephthalate, polyether block amide, etc. Typically, the surface energy of these (untreated) plastics is between 27 mN / m and 45 mN / m, and / or the contact angle with (distilled) water is between 70° and 120°. Therefore, depending on the fluid, it is necessary to increase the surface energy to obtain the desired wettability, preferably by surface treatment and / or (film) coating.

[0044] Additionally or as an alternative, the fluid contains at least one additive, such as benzalkonium chloride, to reduce its surface energy.

[0045] Optionally, the cartridge can be equipped with a submersion / contact element, such as a weight, an anchor, a sponge, etc., which is attached to the tube (especially the free end of the tube), preferably such that at least the free end of the tube remains in the fluid and / or is pulled downward by gravity. This additionally ensures that the tube (at least its free end or tip) remains in contact with the fluid in the container even when the position of the container changes. However, especially when the nebulizer includes movable parts (such as during the tensioning process and / or the atomization process), the size and / or weight of the submersion / contact element needs to be small / light to prevent the formation of foam in the container. The total weight of the tube should be as light as possible to prevent or reduce the formation of foam.

[0046] Alternatively or additionally, the submersion element can also be arranged such that it is located around a (end) portion of the tube and / or surrounds or covers a (end) portion of the tube.

[0047] Preferably, the density of the submersion element is selected such that the submersion element is submerged in the fluid but does not sink to the bottom of the container. In this way, the submersion element does not stick to the container wall and / or restrict the movement of the tube.

[0048] Due to capillary action inside the tube and / or the construction of the tube as a capillary, the tube is automatically filled with fluid and thus (further) ballasted downward.

[0049] Preferably, as described above, the tube is retained in the fluid not only by gravity but to a significant extent / principally by the wettability of the tube. However, gravity (augmented by capillary action and / or by the fluid in the suction tube and / or by the immersion element) and the adhesion force (augmented by wettability) interact in a synergistic manner and ensure that the tip of the tube remains immersed in the fluid, particularly being at least substantially unaffected by its spatial orientation.

[0050] According to another aspect of the invention, the container (particularly its inner surface) is less readily wetted by the fluid than the tube. Thus, less fluid adheres to the (inner) surface or layer of the container, and the total amount of dose that can be dispensed is increased.

[0051] Preferably, the surface energy of the container (particularly its inner surface) is less than the surface energy of the tube and / or less than or equal to the surface tension of the fluid.

[0052] Preferably, the contact angle between the (inner) surface of the container and the fluid droplet is greater than the contact angle between the tube surface and the fluid droplet. Most preferably, the contact angle between the container surface and the fluid droplet is greater than 70° or 90°.

[0053] When using an aqueous fluid and / or an aqueous solution and / or water as a solvent, the container is preferably at least partially hydrophobic and / or includes at least partially hydrophobic and / or non-polar (inner) surface or layer.

[0054] The container or bag (particularly its (inner) surface or layer) can be coated with a material having a low surface energy and / or made of a material having a low surface energy, such as polytetrafluoroethylene (PTFE). Thus, the wettability of the container is reduced, such that less fluid adheres to the (inner) surface or layer of the container or bag.

[0055] Thus, in a synergistic manner, the tube having a higher surface energy (compared to the surface energy of the container) and the container having a lower surface energy (compared to the surface energy of the tube) contribute to increasing the volume of fluid that can be withdrawn from the cartridge. In addition, since no fluid film is formed between the tube and the container, the tube does not stick to the container.

[0056] According to another aspect of the invention, the tube has a minimum bending radius less than half, a quarter or a fifth of the inner diameter of the container. Preferably, when the tube is bent until the minimum bending radius, the tube is kink-resistant. This ensures that the tube can be bent within the cartridge, preferably by at least 180°, without kinking and thus without affecting the fluid withdrawal. Thus, even when the spatial position of the nebulizer or cartridge is changed, such as when the nebulizer / cartridge is inverted, the fluid can still be withdrawn.

[0057] Optionally, the tube may also include a valve that closes when it cannot be ensured that the free end of the tube and / or the immersion element is immersed in the fluid, for example when the tube is not bent at least 90°, 120°, 150° or more in an inverted position, and / or when the valve or the free end of the tube is directed upwards. In this way, air is prevented from being sucked into the delivery mechanism of the nebulizer.

[0058] Preferably, the cartridge includes a closure, particularly preferably a funnel and / or a conical connection port / connector, for fluidly connecting the container to the nebulizer or its pump / pressure generator.

[0059] The position of the closure on the cartridge preferably defines the top of the cartridge. In the following description, terms related to position and orientation, such as top, bottom, above, below, upright, etc., preferably refer to the position of the closure, even when the cartridge is in a different position / orientation.

[0060] Furthermore, the axial direction should be understood as the direction from the closure or the top of the container to the bottom of the cartridge or the container. The radial direction is the direction perpendicular to the axial direction. In the case of a cartridge that is at least substantially cylindrical, the axial direction is the direction of the longitudinal axis of the cylinder, and the radial direction is the direction of the radius of the cylinder.

[0061] The closure, particularly the connection port, preferably extends into the interior of the container and / or preferably holds or forms the axial end of the tube in the central region of the container, preferably such that the free end of the tube can reach the outermost regions of the container, particularly the axial upper and lower ends of the container, i.e., its top and bottom. Due to this construction, the length of the tube can be shortened, and thus the risk of kinking can be reduced.

[0062] According to another aspect of the invention, at least partially flexible delivery / suction / capillary that can be wetted by the fluid is used to draw / deliver a certain dose of preferably polar fluid from the container of the nebulizer, preferably such that the tube (particularly at least its free end) is automatically wetted by a fluid film and / or automatically sucks in the fluid and / or is ballasted by the fluid and / or automatically aligns / bends towards the fluid in the container once it comes into contact with the fluid. In this way, the advantages discussed above can be achieved.

[0063] According to another aspect of the invention, which can also be implemented independently, the tube has a helical shape. Preferably, the helix is a conical helix, particularly preferably, its maximum diameter is at the free end of the tube, and its minimum diameter is at the fixed end of the tube and / or tapers towards the fixed end.

[0064] Preferably, the helix is compressible and / or stretchable, and / or the axial length of the helix is adjustable, particularly such that the free end of the tube always remains immersed in the fluid. Preferably, the helix is adapted to automatically adjust its length to adapt to the fluid or the filling level. This advantageously prevents the tube from getting stuck on the inner wall of the container or the bag.

[0065] The conical helix is preferably compressible into at least substantially two-dimensional or flat helix. In this way, the possibility of the helix or the tube itself jamming is preferably prevented or reduced. Another advantage is that the operation of the tube is easier, for example during the manufacturing process.

[0066] Preferably, the helix is flipped when inverted. The term "flipped" preferably means that the longitudinal or axial extension direction of the helix is flipped. In the upright position, the helix preferably extends from the fixed end of the container or cartridge towards the bottom or the lower end of the axis. In the inverted position, the extension is preferably flipped such that the helix extends from the fixed end of the container or cartridge towards the top or the upper end of the axis or the closure. In particular, the free end of the helix or the tube at least substantially points towards the closure and / or is at least substantially the point on the helix or the tube closest to the closure.

[0067] The proposed helical shape of the tube preferably ensures that the free end of the tube remains immersed in the fluid even when the cartridge is in the inverted position. In this way, it is preferably ensured that it is always possible to withdraw fluid from the cartridge, especially also in the inverted position. For example, this may be advantageous in cases where the tube cannot be bent 180°, such as in very thin cartridges where the inner diameter of the cartridge is small compared to its internal axial length.

[0068] The proposed sprayer comprises a preferably insertable cartridge having a container for receiving the fluid to be atomized, and also comprises a housing for receiving the cartridge and a delivery mechanism for delivering / pressurizing the fluid.

[0069] According to another aspect of the invention which can also be implemented independently, the sprayer comprises a preferably rigid connecting element (especially configured as a capillary) for fluidly connecting the cartridge to the delivery mechanism and a preferably flexible / bendable tube (especially configured as a capillary) for delivering the fluid out of the container, wherein the connecting element and the tube comprise or form a continuous capillary and / or a constant flow area, i.e., there are no voids, dead volumes, gaps and / or capillary blockages at the transition from the tube to the connecting element.

[0070] Any void or gap (also called dead volume) at the transition from the tube to the connecting piece results in an enlarged flow area in this region. When delivering fluid from the tube, this dead volume at the transition needs to be first (completely) filled with fluid before the fluid can continue to be delivered further through the connecting element. Therefore, the dead volume causes capillary blockage where the delivery of the fluid slows down. Therefore, it is desirable to prevent such dead volume or at least keep it as small as possible to ensure a constant flow of fluid along the entire length of the capillary.

[0071] Preferably, the (widest / largest) flow area at the transition from the tube to the connecting element is at least substantially equal to and / or not greater than 120% of the (smallest or largest) flow area of the connecting element and / or the tube.

[0072] In particular, at the transition from the tube to the connecting element, the diameter of the (widest / largest) flow area is smaller than the outer diameter of the tube and / or the connecting element.

[0073] In this way, the flow losses at the transition from the tube to the connecting element are reduced. In particular, the formation of air bubbles at the transition from the tube to the connecting element can be reduced, and / or the capillary action can be used continuously in the tube and the connecting element.

[0074] According to another aspect of the invention, which can also be implemented independently, the cartridge comprises a pierceable or breakable diaphragm or sealing wall. The diaphragm or sealing wall is preferably integrated or arranged within a closure, in particular within a connection port. The diaphragm or sealing wall preferably seals the cartridge (in particular the container or the fluid contained therein) from the environment in the delivery state, which is to be understood as the state of the cartridge before it is connected or inserted into the nebulizer.

[0075] When the cartridge is inserted into the nebulizer or connected to the delivery mechanism of the nebulizer, the sealing wall is preferably adapted to be pierced or broken by the connecting element of the nebulizer. This advantageously prevents the leakage of fluid from the cartridge and / or the contamination of the fluid.

[0076] The diaphragm or sealing wall is preferably integrally formed with or formed as a single unit with the closure or the connection port. Particularly preferably, the diaphragm or sealing wall comprises a peripherally reduced thickness portion and a membrane hinge, both of which are integrally formed with the closure or the connection port.

[0077] Preferably, when the connecting element is inserted into the connection port, the diaphragm or sealing wall tears or ruptures along the peripherally reduced thickness portion and tilts or hinges to one side by means of the membrane hinge. In particular, also after rupture, the diaphragm or sealing wall remains connected to the closure or the connection port by means of the membrane hinge. This ensures that the diaphragm or sealing wall opens or ruptures in a defined and reproducible manner without blocking or hindering the tube, the connecting element and / or the delivery mechanism.

[0078] Preferably, the diaphragm or sealing wall further comprises a connection portion with an increased thickness, in particular a connection portion formed by the membrane hinge, which connects the closure or the connection port to the center of the diaphragm or sealing wall.

[0079] Particularly preferably, the closure or the connection port and the diaphragm or sealing wall are integrally formed as a single unit by injection molding. In this case, the connection portion or the membrane hinge preferably forms a bridging piece or an additional connection through which the molding material can enter the center of the sealing wall, thereby forming the sealing wall, in particular without having to cross the thinner peripherally reduced thickness portion. This advantageously enables or simplifies the injection molding process of the closure or the connection port with the integrated diaphragm or sealing wall. This is advantageous for the low-cost manufacture of the cartridge.

[0080] According to another aspect of the invention, which can also be implemented independently, the cartridge is adapted to sealingly connect the elements, particularly radially. The closure, particularly the connection port, is preferably adapted to surround or seal the connecting element in a liquid-tight and / or gas-tight manner. In particular, the closure or connection port may be stretchable or flexible, at least in part. When the preferably rigid connecting element is inserted into the cartridge, the closure or connection port preferably stretches apart and / or forms an interference fit / tight fit connection with the connecting element.

[0081] According to another aspect of the invention, which can also be implemented independently, the cartridge includes a sealing element located between the closure or connection port and the container of the cartridge. The sealing element preferably seals the container axially and / or radially. This sealing is preferably achieved by an interference fit / tight fit of the sealing element between the closure / connection port and the container.

[0082] Preferably, the sealing element extends into the interior of the container and / or is adapted to sealingly receive the connecting element, particularly by an interference fit / tight fit in a manner similar to that described above for the connection port. In particular, the connecting element is sealingly received by the sealing element after passing through the connection port.

[0083] The seal between the connecting element and the sealing element may be alternative or additional to the seal between the connecting element and the connection port. Particularly preferably, the connecting element is simultaneously sealed or sealingly received by the connection port and the sealing element. In this case, preferably, the seal with the connection port is first formed or established, and after the connecting element or its axial end has passed through the connection port, the seal with the sealing element is formed or established.

[0084] The cartridge or closure may optionally include a fitting, particularly for connecting a tube to the closure or connection port. As an alternative or supplement to the seal between the connecting element and the connection port and / or the sealing element, a seal may also be provided between the fitting and the connecting element, particularly preferably by an interference fit / tight fit in the same manner as described above for the connection port. In a particularly preferred embodiment, the sealing element includes, forms or forms part of the fitting, or vice versa.

[0085] The aspects of the invention mentioned above and below can be implemented independently of each other and in any combination.

[0086] Other advantages, features, characteristics and aspects of the invention will become apparent from the description of the preferred embodiments in the specification and the following description with reference to the drawings.

[0087] Figure 1 is a schematic cross-section of a known nebulizer in a non-tensioned state;

[0088] Figure 2is a schematic cross-section of a known atomizer in a tensioned state, rotated 90° compared to Figure 1 ;

[0089] Figure 3 is a schematic cross-section of a cartridge according to a first embodiment of the present invention;

[0090] Figure 4 is a schematic cross-section of a cartridge according to Figure 3 , connected to the partially shown atomizer;

[0091] Figure 5 is a schematic cross-section of a cartridge according to Figure 4 rotated to a horizontal position;

[0092] Figure 6 is a schematic cross-section of a cartridge according to Figure 4 in an inverted position;

[0093] Figure 7 is a magnified view of a tube of a cartridge according to Figure 3 , removed from the connection port connected to the partially shown atomizer;

[0094] Figure 8 is a schematic cross-section of a cartridge according to a second embodiment of the present invention;

[0095] Figure 9 is a schematic detail of a cartridge according to Figure 8 ;

[0096] Figure 10 is a schematic cross-section of a cartridge according to a third embodiment of the present invention connected to the partially shown atomizer;

[0097] Figure 11 is a schematic detail of a cartridge according to Figure 10 ;

[0098] Figure 12 is another schematic detail of a cartridge according to the third embodiment;

[0099] Figure 13 is a schematic view of a cartridge with a helical tube according to a fourth embodiment of the present invention;

[0100] Figure 14 is a schematic view of a cartridge according to Figure 13 with a higher fluid filling level;

[0101] Figure 15 is a schematic view of a cartridge according to Figure 13 with an additional immersion element;

[0102] Figure 16 is according toFigure 13 Schematic diagram of a variant of a cartridge, where the shape of the tube is a double - conical helix;

[0103] Figure 17 is according to Figure 13 Schematic diagram of another variant of a cartridge, where the shape of the tube is a conical helix;

[0104] Figure 18 is according to Figure 17 Schematic diagram of a cartridge that is inverted and connected to a partially - shown nebulizer;

[0105] Figure 19 Schematic diagram of a cartridge according to the fifth embodiment of the present invention;

[0106] Figure 20 Schematic cross - section of a cartridge according to the sixth embodiment of the present invention;

[0107] Figure 21 Schematic cross - section of a cartridge with a closed diaphragm or sealing wall according to the seventh embodiment;

[0108] Figure 22 Schematic cross - section of a cartridge with an open diaphragm or sealing wall according to the seventh embodiment, the cartridge being connected to a partially - shown nebulizer; and

[0109] Figure 23 Perspective detail of a cartridge according to the seventh embodiment.

[0110] In the drawings, the same reference numerals are used for the same or similar components, preferably resulting in corresponding or comparable characteristics and advantages, even without repeating the relevant description.

[0111] Figure 1 and Figure 2 show a known nebulizer / dispensing device 1 for atomizing / spraying / dispensing a fluid 2, particularly a pharmaceutical composition, a medicament, etc., schematically shown in a non - tensioned state ( Figure 1 ) and a tensioned state ( Figure 2 ).

[0112] The fluid 2 is preferably polar and / or includes an electric dipole moment. In particular, the fluid 2 is aqueous or alcoholic, and / or contains an aqueous or alcoholic solution, and / or contains water or alcohol (especially ethanol) as a solvent.

[0113] The nebulizer 1 is preferably adapted to dispense and / or atomize the fluid 2 or its dose.

[0114] Preferably, when the fluid 2 (preferably a liquid, more specifically a pharmaceutical ingredient) is atomized / dispensed, an aerosol A is formed or dispensed (as Figure 1as shown by the dashed line therein, which can be breathed or inhaled by a user (not shown).

[0115] Typically, the inhalation is performed at least once a day, more specifically, several times a day, preferably at set time intervals, depending on the physical discomfort or disease suffered by the patient.

[0116] The nebulizer 1 is in particular configured as a portable inhaler and / or preferably operates only mechanically and / or without a propellant / gas. However, other configurations are also possible.

[0117] The nebulizer 1 is provided with or includes or is adapted to receive an insertable or replaceable cartridge 3 containing the fluid 2. Thus, the cartridge 3 forms a reservoir for the fluid 2 to be atomized / distributed.

[0118] Figure 1 and Figure 2 A known nebulizer 1 is shown, which has a schematically drawn cartridge 3, wherein Figures 3 to 22 a cartridge 3 according to the present invention or parts thereof is shown. Preferably, some of the features, characteristics and aspects described with respect to Figure 1 and Figure 2 can be applied to the cartridge 3 described with respect to Figures 3 to 22 i.e., the cartridge 3 according to Figures 3 to 22 can include some of the features, characteristics and aspects of the cartridge 3 according to Figure 1 and Figure 2 In particular, the cartridge 3 described in conjunction with Figures 3 to 22 can be used in conjunction with the nebulizer 1 described in conjunction with Figure 1 and Figure 2 described.

[0119] Below, a known cartridge 3 according to Figure 1 and Figure 2 is described.

[0120] Preferably, the cartridge 3 contains a multi-dose of the fluid 2, in particular sufficient to provide at least 100 or 150 and / or up to 200 or more dose units or doses, i.e., allowing at least 100 and / or up to 200 sprays or administrations.

[0121] The cartridge 3 preferably accommodates a volume of about 0.5 ml to 30 ml, particularly preferably about 4 ml to 20 ml. In addition, the number of doses accommodated in the cartridge 3 and / or the total volume of the fluid 2 accommodated in the cartridge 3 can vary depending on the fluid 2 or the corresponding medicament and / or depending on the cartridge 3 and / or depending on the necessary medication, etc.

[0122] Preferably, the nebulizer 1 is adapted to atomize / dispense a dose of fluid 2 of from 1 μl to 80 μl, even more preferably from 5 μl to 20 μl, or a dose of more than 20 μl, in particular a dose of about 50 μl, during one actuation / use of the nebulizer 1 and / or during one spraying / aerosol delivery / dispensing.

[0123] Preferably, the cartridge 3 can be replaced or substituted, in particular as disclosed in WO 2012 / 162305 A1. Preferably, the total number of uses of the nebulizer 1 and the number of cartridges 3 that can be used with the same nebulizer 1 are preferably limited, for example, to a total of four, five or six cartridges 3. WO 2012 / 162305 A1 discloses such a limitation on the total number of cartridges 3 that can be used with the same nebulizer 1.

[0124] The cartridge 3, in particular the container 4, is preferably substantially cylindrical or tubular and / or of rigid construction. However, other configurations are possible. In particular, the cartridge 3 or the container 4 can be at least partially spherical.

[0125] Preferably, once the nebulizer 1 is opened, the cartridge 3 can be inserted therein, preferably from below, and can be replaced if necessary.

[0126] Known cartridges 3 in combination with known nebulizers 1 include a preferably rigid container 4 and / or an optional, preferably flexible / collapsible bag 5 for containing the fluid 2, preferably wherein the optional bag 5 is arranged or held within the container 4.

[0127] Optionally, the cartridge 3 can further include a housing 33, which is preferably rigid and / or made of metal (in particular aluminum). According to a seventh embodiment of the invention, the specific embodiments of such a housing are described in further detail Figure 21 and Figure 22 in combination.

[0128] Preferably, the known cartridge 3 is constructed in combination with a known nebulizer 1 as described in WO 96 / 06011A2 and / or WO 00 / 49988A2.

[0129] Optionally, the cartridge 3 (in particular the container 4) includes a venting / breathing feature 6, such as a valve, an opening or a hole, for venting / breathing of the cartridge 3 (in particular the container 4), preferably in order to enable or support the withdrawal of the fluid 2 from the container 4.

[0130] Preferably, the venting feature 6 forms a direct or indirect gas connection between the interior of the container 4 and its surroundings and / or the atmosphere, and / or allows pressure compensation between the interior of the container 4 and its surroundings and / or the atmosphere.

[0131] When the venting feature 6 is open, air or any other gas can flow into the container 4 through the venting feature 6, making it possible or achieving pressure compensation between the interior of the container 4 and its surrounding environment. In particular, when the fluid 2 is withdrawn and / or the optional bag 5 is collapsed, negative air pressure can be avoided or at least compensated for.

[0132] Figure 1 、 Figure 2 and Figure 20 show an indirect gas connection, where Figures 3 to 6 、 Figure 8 、 Figure 10 and Figures 13 to 18 show a direct gas connection.

[0133] The indirect gas connection allows pressure compensation between the interior of the container 4 and its surrounding environment, enabling the bag 5 to collapse. The air flowing into the container 4 through the venting feature 6 does not come into direct contact with the fluid 2 contained in the bag 5.

[0134] In contrast to the indirect gas connection, as Figures 3 to 6 、 Figure 8 、 Figure 10 and Figures 13 to 18 shown, the direct gas connection allows air to flow into the container 4 and come into direct contact with the fluid 2 contained in the container 4.

[0135] At least for the direct gas connection, preferably, the venting feature 6 includes a sterile filter so that the fluid 2 is not contaminated by impurities or foreign substances in the air or any other gas. For the indirect gas connection, since the gas does not come into direct contact with the fluid 2, the sterile filter can be omitted. However, a sterile filter for the indirect gas connection can also be provided for the venting feature 6.

[0136] Preferably, the venting feature 6 opens automatically and / or opens before or during the first use of the nebulizer 1.

[0137] Alternatively, the cartridge 3 (especially the container 4) is pressurized, for example with a propellant / gas, preferably with a pressure greater than 2 MPa or 3 MPa and / or less than 10 MPa or 8 MPa, especially such that the venting / breathing feature can be omitted and / or the pressure in the cartridge 3 or the container 4 decreases with each delivery of a certain dose of the fluid 2.

[0138] The cartridge 3 is preferably closed and / or sealed and / or preferably includes a closure 7, preferably where the closure 7 is adapted to close and / or seal the container 4 and / or the bag 5, especially in an airtight and / or liquid-tight manner.

[0139] Optionally, the venting feature 6 is integrated in the closure 7 and / or opens together with the closure 7, as described in WO2006 / 136426A1, for example on page 9, line 20 to page 14, line 2.

[0140] In such an embodiment, the venting feature 6 (e.g., a thin duct) is preferably opened / generated by opening / piercing the closure 7, in particular, where pressure compensation occurs through the venting feature 6 while no leakage of the fluid 2 occurs through this venting feature.

[0141] Preferably, the cartridge 3 (in particular the closure 7) comprises a preferably pierceable seal 8 and / or a preferably flexible, in particular funnel-shaped and / or conical connection port / connector 9.

[0142] The seal 8 is schematically shown in Figure 3 where the cartridge 3 according to the first embodiment of the invention is in a closed / non-pierced state. According to the seventh embodiment of the invention, the seal 8 is further schematically shown in Figure 21 in its closed / non-pierced state, while in Figure 22 its opened / pierced state is shown. Figure 23 Details of the seal 8 according to the seventh embodiment are shown.

[0143] At least before the cartridge 3 is inserted into the nebulizer 1, the seal 8 preferably covers or seals the container 4 and / or the connection port 9.

[0144] Preferably, the seal 8 can be implemented as a foil 8A and / or a diaphragm or a sealing wall 31, in particular a septum or a spacer, most preferably, where the foil 8A covers the connection port 9, and / or the diaphragm or the sealing wall 31 is integrated in and / or arranged within the connection port 9.

[0145] The preferred configuration of the diaphragm or the sealing wall 31 will be described in further detail later in connection with Figures 21 to 23 further.

[0146] Figure 3 and Figure 21 、 Figure 22 The cartridge 3 shown in and comprises a foil 8A and a diaphragm or a sealing wall 31, preferably, where when the cartridge 3 is inserted and / or connected to the inhaler 1, the connecting element 14 of the inhaler 1 pierces or breaks / open the foil 8A and the diaphragm or the sealing wall 31.

[0147] The cartridge 3 preferably comprises a (further) seal S1 between the container 4 and the closure 7. In Figures 3 to 8 、 Figure 10 and Figure 20 this seal S1 is shown as a sealing element 32, for example in the form of a sealing ring located between the container 4 and the closure 7. In particular, the seal S1 and / or the sealing element 32 axially seals the cartridge 3. However, other solutions are also possible here, particularly preferably as in Figure 21 and Figure 22The seal S1 or the sealing element 32 shown, which will be described in more detail below in connection with the seventh embodiment of the present invention.

[0148] The nebulizer 1 preferably comprises a delivery / pressurizing mechanism 10, preferably a pressure generator or a pump, for sucking, pressurizing, delivering and / or atomizing / distributing a fluid 2, in particular in a preset dose and optionally in an adjustable dose.

[0149] In particular, the delivery mechanism 10 preferably sucks or draws in the fluid 2, i.e. a certain dose of the fluid 2, from the cartridge 3 (in particular from the container 4 and / or the bag 5) when the nebulizer 1 is cocked or tensioned or loaded. Subsequently, the fluid 2 or a certain dose of the fluid 2 drawn in preferably in a second step is distributed, in particular pressurized and / or atomized, in a second step in which the mechanical energy stored during the earlier tensioning is released.

[0150] Specifically, the nebulizer 1 comprises an energy storage means (preferably a drive spring 12) which is loaded (preferably tensioned) during the loading or tensioning process and during which the energy is released for atomizing the fluid 2 or a certain dose of the fluid 2 which has been drawn into the nebulizer 1. Thus, the normal use of the nebulizer 1 comprises a loading process and a distribution process.

[0151] The nebulizer 1 or the delivery mechanism 10 preferably comprises a holder 11 for holding the cartridge 3, a drive spring 12 associated with the holder 11 (partially shown in Figure 1 and Figure 2 ), and / or a blocking element 13, preferably in the form of a button or with a button, for preferably manually actuating or pressing.

[0152] The blocking element 13 can preferably lock and block the holder 11 and / or can be manually operated to release the holder 11, thereby allowing the drive spring 12 to expand.

[0153] The nebulizer 1 or the delivery mechanism 10 preferably comprises a delivery / connection element 14, such as a delivery tube, a check valve 15, a pressure chamber 16, a nozzle 17 for atomizing the fluid 2 and / or a mouthpiece 18.

[0154] The fully inserted cartridge 3 (preferably its closure 7) is fixed or held in the nebulizer 1 by the holder 11, preferably in a form-fitting manner, in particular such that the connection element 14 fluidly connects the container 4 and / or the bag 5 to the nebulizer 1 or the delivery mechanism 10.

[0155] Preferably, when the cartridge 3 is inserted into the nebulizer 1 and / or the cartridge 3 is connected to the delivery mechanism 10, the connecting element 14 at least partially penetrates into the container 4 and / or the bag 5 and / or pierces or ruptures the seal 8, and / or is sealingly received by the connection port 9, in particular in a tight fit manner, and particularly preferably a seal S2 is formed between the connection port 9 and the connecting element 14.

[0156] In particular, the cartridge 3 has or forms an insertion opening for the connecting element 14, preferably formed in or by the closure 7. The opening preferably includes a first part that is preferably funnel-shaped and a second part that is preferably cylindrical. The first part preferably tapers towards the second part. In particular, the second part has at least a substantially constant diameter, which preferably corresponds to the diameter of the connecting element 14. The opening may initially be covered or closed, in particular by the seal 8.

[0157] The first part is preferably configured such that it can align and / or guide the connecting element 14 into the second part.

[0158] The second part preferably has a diameter that is (slightly) smaller than the outer diameter of the connecting element 14. In particular, when receiving the connecting element 14, the second part flexibly deforms / stretches to surround the connecting element 14.

[0159] In this way, the seal S2 is formed by a press fit / tight fit between the connecting element 14 and the second part, in particular at least substantially over the entire length of the second part. In addition, the cartridge 3 or the closure 7 is preferably adapted to compensate for the radial length tolerances of the connecting element 14.

[0160] Preferably, the connecting element 14 is configured as an elongated hollow cylinder, in particular a needle, and / or includes a tapered / sharp end.

[0161] Preferably, the connecting element 14 is rigid, in particular made of metal, most preferably made of stainless steel, and / or is adapted to pierce or rupture the seal 8, in particular the foil 8A and / or the diaphragm or the sealing wall 31.

[0162] Most preferably, the connecting element 14 is configured as a capillary, in particular with an inner diameter less than 1 mm or 0.8 mm, most preferably less than 0.7 mm or 0.5 mm, and / or greater than 0.1 mm or 0.2 mm. However, the inner diameter should not be too small, as this would reduce the flow rate that can be achieved within the connecting element 14.

[0163] The nebulizer 1 (in particular the holder 11) is preferably configured such that the cartridge 3 can be released or replaced.

[0164] When the drive spring 12 is axially tensioned during the tensioning process or during the cocking process, the holder 11, the cartridge 3 and the connecting element 14 move downward and / or towards the base of the cartridge 3.

[0165] By the movement of the connecting element 14 downward and / or towards the base of the cartridge 3, the volume of the pressure chamber 16 increases and / or the pressure in the pressure chamber 16 decreases, such that in particular the fluid 2 is withdrawn or sucked out of the container 4 and / or the bag 5 via the connecting element 14 and into the delivery mechanism 10, in particular through the check valve 15 into the pressure chamber 16. In this state, the holder 11 is blocked by the blocking element 13 such that the drive spring 12 remains compressed. Subsequently, the nebulizer 1 is in the cocked or tensioned state.

[0166] During the subsequent relaxation during the dispensing / atomization process, i.e. after actuating or pressing the blocking element 13, the connecting element 14 and its now closed check valve 15 move back upward into the pressure chamber 16 (in Figure 1 and Figure 2 ), thereby reducing the volume of the pressure chamber 16. Due to the now closed check valve 15, the fluid 2 or a dose thereof in the pressure chamber 16 is pressurized. Thus, in this state, the check valve 15 acts as a squeezing ram or piston.

[0167] The pressure generated in this way forces the fluid 2 or its dose through the nozzle 17, and the fluid is thus atomized into an aerosol A, as shown by the dashed line in Figure 1 ).

[0168] Generally, the nebulizer 1 operates with a spring pressure on the fluid 2 of 5 MPa to 300 MPa, preferably 10 MPa to 250 MPa, and / or with a volume of the fluid 2 delivered per stroke of 10 μl to 50 μl, preferably 10 μl to 20 μl, in particular about 15 μl. Alternatively, the nebulizer 1 operates with a volume of the fluid 2 delivered per stroke greater than 20 μl, in particular about 40 or 50 μl.

[0169] The fluid 2 is converted into or atomized into an aerosol A, the droplets of which have an aerodynamic diameter of at most 20 μm (preferably 3 μm to 10 μm).

[0170] Preferably, the resulting spray jet is conical and / or has an opening angle of 20° to 160° (preferably 80° to 100°).

[0171] The user or patient (not shown) can inhale the aerosol generated in this way, and preferably, air can be inhaled through the mouthpiece 18 through at least one optional air supply opening 19 at the same time.

[0172] The nebulizer 1 preferably comprises a housing 20 having an upper housing part 21, a lower housing part 22 and / or an inner housing part 23.

[0173] The inner housing part 23 and / or the lower housing part 22 are preferably rotatable relative to the upper housing part 21. In particular, the lower housing part 22 is manually operable and / or releasably fixable, in particular fitted or held on the inner housing part 23, preferably by means of a retaining element.

[0174] For inserting and / or replacing the cartridge 3 , preferably the housing 20 can be opened and / or the lower housing part 22 can be removed from the nebulizer 1 , in particular from the inner housing part 23 .

[0175] Preferably, the cartridge 3 can be inserted before the housing 20 is closed and / or before the lower housing part 22 is connected to the inner housing part 23 or the upper housing part 21. Alternatively, the cartridge 3 can be automatically or simultaneously inserted, opened and / or fluidically connected to the delivery mechanism 10 when the lower housing part 22 is (completely) connected to the upper housing part 21 and / or the inner housing part 23 and / or when the housing 20 or the nebulizer 1 is (completely) closed.

[0176] The lower housing part 22 is preferably formed as a cap-shaped lower housing part and / or surrounds or fits over the lower free end of the cartridge 3 .

[0177] Preferably, the nebulizer 1 or the drive spring 12 can be actuated or tensioned or charged manually, in particular by actuation or rotation of a drive member, here preferably by rotation of the lower housing part 22 or any other component.

[0178] The actuation member, preferably the lower housing part 22 , can be actuated, here rotated relative to the upper housing part 21 , bringing with it or driving the inner housing part 23 .

[0179] The inner housing part 23 acts on a gear or transmission to convert the rotation into an axial movement of the holder 11 and the cartridge 3. As a result, the drive spring 12 is tensioned axially by a gear or transmission (not shown) formed between the inner housing part 23 and the holder 11.

[0180] During the tensioning process, the cartridge 3 and the holder 11 are moved axially downwards until the cartridge 3 occupies or reaches an end position, such as Figure 2 In this activated or tensioned state, the drive spring 12 is in a tensioned state and can be caught or held by the blocking element 13 .

[0181] During the atomization process, the cartridge 3 is moved back to its initial position ( Figure 1 The cartridge 3 thus performs a lifting or stroke movement during the tensioning process and the atomization process.

[0182] As the drive spring 12 is tensioned, the end of the cartridge 3 moves into or towards the end face of the lower housing part 22.

[0183] The venting means (such as the piercing element 24 provided in the lower housing part 22) preferably opens or pierces the cartridge 3, preferably the container 4, in particular the breathable feature 6, upon first contact with the cartridge 3. Thereby, air can flow into the cartridge 3 (in particular the container 4), and pressure compensation can occur when the fluid 2 is withdrawn from the cartridge 3 during tensioning of the nebulizer 1. As described above, other configurations are also possible, in particular when the optional bag 5 is omitted. Such an embodiment will be described below with reference to Figures 3 to 19 description of such an embodiment.

[0184] According to Figures 3 to 23 the various embodiments shown, in particular according to Figures 3 to 7 the first embodiment shown, the cartridge 3 preferably comprises a tube 25, in particular a capillary / suction / delivery tube, particularly preferably for sucking and / or delivering the fluid 2 out of and / or into the container 4 and / or to the delivery mechanism 10 or the connecting element 14.

[0185] The tube 25 is preferably configured as an elongated hollow cylinder or capillary.

[0186] Preferably, the tube 25 comprises a first axial end or fixed end 25A and a second axial end or free end 25B, preferably, wherein the first axial end or fixed end 25A is fixed / attached to or formed by the closure 7 or the connection port 9, and / or the second axial end or free end 25B is movable freely within the container 4, which will be described in more detail below.

[0187] In particular, the tube 25 or the fixed end 25A is directly or indirectly connected to the closure 7 or the connection port 9.

[0188] Preferably, Figures 3 to 19 the embodiments shown do not include a flexible / collapsible bag 5, in particular because the bag 5 would interfere with the tube 25 and / or limit its ability to move freely within the container 4. However, Figures 3 to 19 the embodiments shown may also incorporate the bag 5 with reference to Figure 1 , Figure 2 and Figure 20 described bag 5.

[0189] The tube 25 is preferably arranged entirely within the container 4 and / or preferably extends entirely within the container 4.

[0190] Preferably, the tube 25 (in particular its fixed end 25A) is mechanically and / or fluidly connected (preferably in a form-fitting and / or press-fitting manner and / or by adhesion) to the closure 7 or the connection port 9, preferably via an optional joint 26.

[0191] Preferably, the adapter 26 preferably connects the tube 25 (i.e., its fixed end 25A) to the connection port 9 of the closure 7 in a form-fitting and / or press-fitting manner and / or by adhesion.

[0192] In particular, the closure 7 may include the adapter 26.

[0193] In Figures 3 to 7 the illustrated embodiment, the adapter 26 and the tube 25 are preferably formed as one piece. Most preferably, the tube 25 (especially its fixed end 25A) widens towards the closure 7 and / or (thereby) forms the adapter 26. However, other solutions are possible, especially where the adapter 26 is formed as a separate part, as will be described in connection with Figure 8 and Figure 9 the second embodiment shown in Figures 21 to 23 and the seventh embodiment shown in

[0194] Preferably, the adapter 26 is funnel-shaped and / or conical and / or attached to the connection port 9. In particular, the adapter 26 is flexible and / or adapted to sealingly receive the connection port 9 and / or the connecting element 14, especially its axial end, most preferably in a press-fit / tight-fit manner. Particularly preferably, seals S3 and S4 are respectively formed between the adapter 26 and the connecting element 14 or the connection port 9.

[0195] Preferably, the adapter 26 forms a seal between the tube 25 and the connection port 9 and / or between the tube 25 and the connecting element 14, especially its axial end and / or its outer edge. In particular, the adapter 26 is adapted to connect the tube 25 to the connection port 9 and / or the connecting element 14 in a liquid-tight and / or gas-tight manner.

[0196] Preferably, the connection port 9 and / or the adapter 26 are adapted to compensate for the length tolerance of the connecting element 14, and / or include a compensation area for sealingly receiving connecting elements 14 of different lengths, which will be described in more detail below with reference to Figures 4 to 7 as well as Figure 21 and Figure 22 further described.

[0197] Alternatively, the tube 25 is formed by the connection port 9 and / or molded onto the connection port 9. In such an embodiment, the connection port 9 and the tube 25 are preferably formed as one piece, especially where the connection port 9 tapers (especially continuously) into the tube 25.

[0198] Preferably, the tube 25 (at least its fixed end 25A) is (firmly) held or fixed in the central region of the container 4. In particular, the closure 7 or the connection port 9 holds or merges / tapers into the tube 25, especially the fixed end 25A, preferably in the central region of the container 4.

[0199] Preferably, the closure 7 or the connection port 9 extends into the container 4 such that the tube 25 is held in the central region of the container 4, and / or the connection port 9 merges / tapers into the tube 25 in the central region of the container 4.

[0200] Preferably, the tube 25 is shorter than the container 4, i.e., its length is shorter than the height of the container 4, in particular such that the entire / extended tube 25 can be arranged within the container 4.

[0201] In particular, the tube 25 is positioned and / or held within the container 4 in such a way that the tube 25 (i.e., its free end 25B) does not touch and / or does not come into contact with or hardly touches the wall or bottom of the container 4 in the extended state. This reduces the risk of interference between the tube 25 and the container 4 and thus reduces the restriction on its movement.

[0202] Preferably, the length of the tube 25 is shorter than the height of the container 4 but longer than half the height of the container 4.

[0203] Preferably, the length of the tube 25 is less than 100 mm or 80 mm, in particular less than 70 mm or 60 mm, and / or greater than 5 mm or 10 mm, in particular greater than 15 mm or 20 mm.

[0204] The length of the tube 25 is preferably defined as the distance from the fixed end 25A to the free end 25B of the tube 25 and / or the length of the portion of the tube 25 having a constant inner diameter and / or outer diameter and / or constant wall thickness.

[0205] As previously described, the tube 25 is preferably configured as a capillary tube, in particular such that (due to capillary action) the fluid 2 is automatically drawn into the tube 25, preferably such that the tube 25 is ballasted by the fluid 2 due to capillary action. Most preferably, the configuration of the capillary tube and the wettability of the tube 25 result in the tube 25 being immersed in the fluid 2, preferably independent of the spatial orientation of the cartridge 3, which will be described further below.

[0206] Capillary action is the ability of a fluid (i.e., a liquid) to flow in a narrow space (i.e., a capillary tube), even against the direction of gravity, due to the wettability of the capillary surface and / or the adhesion of the fluid to the capillary surface.

[0207] The gravitational force F generated by the liquid column in a vertically placed capillary tube G can be described as:

[0208] F G = m x g = πr 2 hρg,

[0209] where m is the mass of the liquid column, r is the (inner) radius of the capillary tube, h is the height / level of the liquid column above the fluid surface / level outside the capillary tube, ρ is the density of the liquid, and g is the acceleration due to gravity.

[0210] The force F caused by the surface tension σ of the capillary surface S and the surface tension σ between the capillary surface and the liquid SF can be described by Young's equation, as mentioned above, where the surface tension of the liquid is σ F , and the contact angle between the liquid and the capillary surface is Θ, then:

[0211] F = [σ S - σ SF x 2πr = cos(Θ)σ F x 2πr

[0212] In the static state, the force F G is equal to the force F. Therefore, the height h of the liquid column can be described by the following equation (also known as Jurin's law):

[0213] h = 2[σ S - σ SF / [rρg] = 2cos(Θ)σ F / [rρg]

[0214] It is applicable to increasing the height h of the fluid / liquid column in the capillary by increasing the surface tension σ of the capillary surface S , i.e., the term |σ S – σ SF | or cos(Θ)σ F , and / or by reducing the radius r of the capillary.

[0215] Preferably, the flow area (especially the inner diameter) of the tube 25 corresponds to and / or matches the flow area and / or inner diameter of the connecting element 14.

[0216] Preferably, the inner diameter of the tube 25 is less than or particularly preferably equal to the inner diameter of the connecting element 14. In particular, capillary blockage at the transition from the tube 25 to the connecting element 14 is thus minimized or prevented.

[0217] Preferably, the (minimum) inner diameter of the tube 25 is less than 1 mm or less than 0.8 mm, especially less than 0.7 mm or less than 0.5 mm, and / or greater than 0.1 mm or greater than 0.2 mm. However, the inner diameter of the tube 25 should not be too small, as this would reduce the flow rate within the tube 25.

[0218] Preferably, the ratio of the length of the tube 25 to the inner diameter is greater than 10 or 20 and / or less than 100 or 80.

[0219] Preferably, the height of the fluid / liquid column in the tube 25 caused by capillary action is at least 20% or 40% of the length of the tube 25, especially 50% or 80%.

[0220] Due to capillary action, the energy required to withdraw a certain dose of fluid 2 from the cartridge 3 is reduced. In addition, the tube 25 is ballasted downward by the weight of the fluid 2 drawn into the tube 25.

[0221] Preferably, the wall thickness of the tube 25 is less than 1 mm or 0.8 mm, in particular less than 0.7 mm or 0.6 mm, particularly preferably less than 0.4 mm or 0.3 mm, and / or greater than 0.05 mm or 0.1 mm, in particular greater than 0.12 mm or 0.14 mm.

[0222] The tube 25 is at least partially flexible and / or bendable and / or kink-resistant, in particular such that the tube 25 can be bent within the container 4 or the bag 5 without kinking, at least when bent to a radius greater than its minimum bending radius.

[0223] Preferably, the cartridge 3 includes an anti-kinking device 26A, as Figure 6 shown, which protects the tube 25 from excessive bending and / or prevents kinking of the tube 25. The anti-kinking device 26A is preferably connected to the closure 7, the connection port 9 and / or the adapter 26 or is formed by the closure 7, the connection port 9 and / or the adapter 26. In particular, the anti-kinking device surrounds or forms a sleeve of a portion of the tube 25 near or adjacent to the fixed end 25A.

[0224] Optionally, the anti-kinking device 26A is formed by the tube 25, preferably by a thickened tube wall near the fixed end 25A.

[0225] The anti-kinking device 26A preferably has a cylindrical or particularly preferably conical or funnel-shaped form, in particular tapering towards the fixed end 25A. The anti-kinking device 26A can be rigid or can be made of a soft material, in particular partially flexible, to support bending of the tube 25 up to a certain bending radius.

[0226] The anti-kinking device 26A preferably defines or delimits the bending radius of the tube 25.

[0227] Most preferably, the tube 25 has a minimum bending radius less than half, preferably a quarter, in particular a fifth of the inner diameter of the container 4. Preferably, the inner diameter of the (cylindrical or spherical) container 4 corresponds to the smallest diameter of the cross-sectional area of the container 4. In this way, the tube 25 can be bent sufficiently within the container 4, thereby allowing the fluid 2 to be discharged in other spatial orientations besides the vertical placement, for example in the horizontal position.

[0228] Preferably, the bending radius of the tube 25 is less than 15 mm or 10 mm, preferably less than 8 mm or 6 mm, in particular less than 5 mm or 3 mm, and / or greater than 1 mm or 2 mm.

[0229] Preferably, when the tube 25 is bent to its minimum bending radius, the inner diameter of the tube 25 is reduced by at most 10%. In particular, the minimum bending radius is the radius at which the tube 25 can be bent to this radius without kinking and / or without reducing the inner diameter of the tube 25 by more than 10% of its initial inner diameter (i.e., the inner diameter of the tube 25 in the deployed / unbent state). This ensures that even when the tube 25 is bent to its minimum bending radius, the fluid 2 can be withdrawn from the container 4 or the bag 5.

[0230] Preferably, the tube 25 is flexible or bendable and / or of suitable length such that its free end 25B can reach the outermost regions of the container 4 or the bag 5, i.e., the upper axial end or the top of the container 4 and / or the lower axial end or the bottom of the container 4, which will be described further below.

[0231] The tube 25, the closure 7, the connection port 9, and / or the fitting 26 are preferably made of rubber, particularly butyl rubber, and / or made of (flexible) plastic, particularly thermoplastic and / or thermoplastic elastomer, such as polyamide, polyethylene, polypropylene, polybutylene terephthalate, or polyether block amide, etc. Other suitable materials can also be used.

[0232] Preferably, the material of the tube 25 and / or the fitting 26 is selected according to the nature of the fluid 2, particularly such that the tube 25 and / or the fitting 26 can be wetted by the fluid 2, i.e., the surface energy of the tube 25 is greater than or equal to the surface tension of the fluid 2 and / or the contact angle between the droplet of the fluid 2 and the surface of the tube 25 is less than 70° or 60°, preferably less than 50° or 30°, and most preferably less than 20°.

[0233] For example, when the fluid 2 is aqueous and / or contains an aqueous solution and / or water as a solvent and / or has a surface tension greater than 65 mN / m and / or less than 75 mN / m, the material of the tube 25 should have a surface energy greater than 75 mN / m or 80 mN / m. When the fluid 2 is ethanol and / or contains an ethanol solution and / or ethanol as a solvent and / or has a surface tension greater than 15 mN / m and / or less than 30 mN / m, the material of the tube 25 should have a surface energy greater than 30 mN / m or 35 mN / m.

[0234] The surface energy of untreated polyethylene is generally between 27 mN / m and 36 mN / m. The surface energy of untreated polypropylene is generally between 28 mN / m and 34 mN / m. Therefore, when used with a fluid 2 having a higher surface tension (such as an aqueous solution), it is necessary to adjust the properties of these materials to improve wettability.

[0235] To obtain the desired properties of the tube 25, i.e., to increase its surface energy and / or wettability, the tube 25 is preferably surface-treated, particularly by corona, plasma, flame, wet chemical treatment, and / or (film) coating.

[0236] In particular, such surface treatment can also increase the polarity of the surface of the tube 25, which increases its wettability with respect to the aqueous or polar fluid 2 (such as water or ethanol).

[0237] In addition or alternatively, the tube preferably comprises at least one additive, in particular at least one primer, to increase its surface energy and / or wettability and / or polarity.

[0238] For example, the surface energy of polyethylene and polypropylene can be increased to more than 40 mN / m by plasma surface treatment.

[0239] Additionally or as an alternative, the fluid 2 can be modified with at least one additive (such as benzalkonium chloride) to reduce its surface tension.

[0240] Preferably, the material of the tube 25 or its free end 25B is chosen such that the density of the tube 25 or its free end 25B is greater than the density of the fluid 2, in particular 10%, 25% or 50% greater than the density of the fluid 2, to assist the immersion of the free end 25B in the fluid 2.

[0241] For example, in the case where the fluid 2 is aqueous and / or contains an aqueous solution and / or water as a solvent and / or has a density greater than 1 g / cm 3 and / or less than 1.2 g / cm 3 the material of the tube 25 or its free end 25B should have a density greater than 1.2 g / cm 3 or 1.3 g / cm 3 In the case where the fluid 2 is ethanol and / or contains an ethanol solution and / or ethanol as a solvent and / or has a density greater than 0.8 g / cm 3 and / or less than 1 g / cm 3 the material of the tube 25 or its free end 25B should have a density greater than 1 g / cm 3 or 1.1 g / cm 3

[0242] Figure 4 Fig. shows a schematic cross-section of the cartridge 3 attached to the holder 11 of the nebulizer 1. In this state, the connecting element 14 has pierced the seal 8 and extends into the cartridge 3, in particular into the container 4.

[0243] Preferably, the cartridge 3 (in particular the connection port 9 and / or the optional adapter 26) is adapted to receive the connecting element 14 (preferably its axial end and / or outer edge) in a sealed manner, in particular in a press-fit / tight-fit manner and / or such that a fluid and / or tight connection can be established between the cartridge 3 and the delivery mechanism 10 (as Figures 4 to 6 shown).

[0244] ​Preferably, the connection port 9 and / or the adapter 26 are flexible and / or stretchable.

[0245] In particular, the connection element 14 is connected to the connection port 9 in a press-fit manner (once inserted).

[0246] Most preferably, the connection element 14 expands the (flexible) connection port 9 (laterally), in particular such that a liquid-tight and / or gas-tight connection or seal S2 is formed between the connection port 9 and the connection element 14.

[0247] Alternatively or in addition, the connection element 14 is connected to the adapter 26 in a sealed and / or press-fit manner (once inserted). In particular, the connection element 14 (preferably its axial end and / or its outer edge) expands the (flexible) adapter 26, in particular such that a liquid-tight and / or gas-tight connection or seal S3 is formed between the connection element 14 (preferably its axial end and / or its outer edge) and the adapter 26.

[0248] Here, both the connection port 9 and the adapter 26 are connected to the connection element 14 in a sealed and / or press-fit manner. In other words, two sealing positions or seals S2, S3 are established with the connection element 14: the first between the side or shell surface of the connection element 14 and the connection port 9, and the second between the axial end of the connection element 14 and the adapter 26.

[0249] Preferably, even when using connection elements 14 of different lengths and / or when axially moving the connection element 14, a sealed connection or seal S2 between the connection element 14 and the connection port 9 and / or a seal S3 between the connection element 14 and the adapter 26 can be established, since the connection element 14 is received and / or connected to the connection port 9 and / or the adapter 26 in a laterally / radially sealed manner. In this way, the length tolerances of the connection element 14 can be compensated for.

[0250] In the state of the cartridge 3 as Figure 4 shown, the container 4 is almost empty, i.e., the volume of the fluid 2 has been reduced to such an extent that only a small amount of the fluid 2 remains.

[0251] Preferably, the cartridge 3 is adapted to be completely emptied and / or 90% or more (in particular 95% or more) of its initial volume of the fluid 2 can be withdrawn through the nebulizer 1 or the delivery mechanism 10 (in particular through the tube 25).

[0252] Furthermore, the cartridge 3 is preferably adapted such that the fluid 2 can be withdrawn from the container 4 with at least substantially no influence from its spatial orientation, as Figures 4 to 6 shown by comparison with each other.

[0253] Figure 5 Shows according to Figure 4The cartridge 3 connected to the delivery mechanism 10, but is rotated or held in a horizontal position, i.e., such that the remaining fluid 2 no longer accumulates at the bottom or axial lower end of the container 4, but due to gravity G accumulates on its longitudinal side.

[0254] Figure 6 Shows a cartridge 3 according to Figure 4 connected to the delivery mechanism 10, but inverted, i.e., in a state where the cartridge 3 is placed above the delivery mechanism 10 and / or such that the remaining fluid 2 no longer accumulates at the bottom or axial lower end of the container 4, but due to gravity G accumulates at its top or axial upper end, i.e., at the closure 7.

[0255] Preferably, the tube 25 is flexible or bendable such that its free end 25B bends (preferably automatically) towards the (remaining) fluid 2 or bends according to gravity G, and / or its free end 25B remains in the (remaining) fluid 2, in particular such that the fluid 2 can be withdrawn from the container 4 with at least substantially no influence from the spatial orientation of the cartridge 3 and / or from any region of the container 4, preferably even from the outermost region of the container 4, i.e., at the lower end or bottom of the container 4, on the longitudinal side of the container 4 and at the upper end or closure 7 of the container 4.

[0256] In particular, the fluid 2 accumulates at the lowest point within the container 4 due to gravity G. Preferably, for any spatial orientation, especially when inverted, the free end 25B of the tube 25 is at least substantially automatically located at or adjacent to the lowest point within the fluid 2 in the cartridge 3 or container 4.

[0257] Preferably, the bending of the tube 25 is automatically achieved, especially due to the weight / gravity of the tube 25 itself and / or its wettability.

[0258] Preferably, the tube 25 is configured such that when the cartridge 3 or the nebulizer 1 is rotated to a horizontal position, as Figure 5 shown, its bending (preferably due to its own weight and / or its wettability) is greater than 10°, 20° or 30°, especially at least substantially 45°, and / or its free end 25B touches the longitudinal side.

[0259] In particular, the tube 25 is configured such that when the cartridge 3 or the nebulizer 1 is inverted, as Figure 6 shown, its bending (preferably due to its own weight and / or its wettability) is greater than 90°, 120° or 150°, especially at least substantially 180°, and / or its free end 25B touches the upper end or closure 7 of the container 4.

[0260] Optionally, the cartridge 3 includes a submersion / contact element 27, such as a weight, sponge, anchor, etc., preferably, where the submersion element 27 is attached to the tube 25 (especially its free end 25B) or formed by it.

[0261] Preferably, the tube 25 and the immersion element 27 are separate parts. However, the tube 25 and the immersion element 27 can be formed as a single unit. For example, the wall thickness of the free end 25B of the tube 25 can be increased compared to the adjacent wall thickness. In this way, the free end 25B of the tube 25 can form the immersion element 27.

[0262] In an alternative embodiment (not shown), the immersion / contact element 27 is formed by expansion of the material of the tube 25 and / or integrally with the tube 25.

[0263] The immersion element 27 preferably has a weight greater than 1 mg or 3 mg, particularly greater than 5 mg or 10 mg, and / or less than 500 mg or 400 mg, particularly less than 300 mg or 200 mg.

[0264] The immersion element 27 preferably includes a volume greater than 1 mm 3 or 2 mm 3 and / or less than 1000 mm 3 or 125 mm 3 of volume.

[0265] Preferably, the immersion element 27 is adapted to increase the gravitational force acting on the tube 25 (particularly its free end 25B), thereby causing the tube 25 to bend according to the gravitational force G and / or the spatial orientation of the sprayer 1 or the cartridge 3.

[0266] Preferably, the tube 25 and / or the immersion element 27 includes an optional lateral inlet 28, such as a notch, a recess or a channel, preferably extending laterally / radially with respect to the longitudinal extension or the axial channel / inlet of the tube 25 and / or through the wall of the tube 25 or the immersion element 27.

[0267] Preferably, the fluid 2 can be laterally / radially drawn in through the lateral inlet 28 and / or through two different inlets (such as the axial channel / inlet of the tube 25 and an additional lateral inlet 28). This prevents the tube 25 from adhering to the wall of the container 4 when drawing in the fluid 2 and / or prevents the wall of the container 4 from (completely) closing the tube 25.

[0268] In particular, the immersion element 27 can be adapted such that at least one inlet is at a certain distance from the wall of the container 4, regardless of the orientation or position of the tube 25 or the immersion element 27. This further prevents blockage of the free end 25B.

[0269] The immersion element 27 preferably has a greater density than the fluid 2, particularly 10%, 25% or 50% greater than the fluid, in order to facilitate immersion in the fluid 2.

[0270] For example, when the fluid 2 is aqueous and / or contains an aqueous solution and / or water as a solvent and / or has a density greater than 1 g / cm 3and / or less than 1.2 g / cm 3 In the case of, the material of the immersion element 27 should have a density greater than 1.2 g / cm 3 or 1.3 g / cm 3 In the case of, the fluid 2 is ethanol and / or contains an ethanol solution and / or ethanol as a solvent and / or has a density greater than 0.8 g / cm 3 and / or less than 1 g / cm 3 In the case of, the immersion element 27 should have a density greater than 1 g / cm 3 or 1.1 g / cm 3 of density.

[0271] In particular, when providing an immersion element 27 with a density greater than that of the fluid 2, the tube 25 can be made of a material with a density similar to or even less than that of the fluid 2.

[0272] The tube 25, the connector 26 and / or the immersion element 27 are wettable and / or include / preferably include at least partially wettable surfaces, in particular hydrophilic and / or polar surfaces. In particular, at least the free end 25B of the tube 25 includes a partially wettable surface, in particular a hydrophilic and / or polar surface. However, preferably, the entire surface of the tube 25 is wettable, in particular hydrophilic and / or polar.

[0273] Preferably, the outer / sheath and / or inner surface of the tube 25, the connector 26 and / or the immersion element 27 is at least partially surface-treated, in particular by corona, plasma or flame treatment, preferably in order to increase its polarity and / or wettability.

[0274] Due to the hydrophilic and / or polar surfaces and / or polarity / wettability of the tube 25, the connector 26 and / or the immersion element 27, the tube 25, the connector 26 and / or the immersion element 27 (in particular their / its surfaces) are easily wetted by the fluid 2, and / or once wetted and / or immersed in the fluid 2, the tube 25 (at least its free end 25B) is held / pulled in the fluid 2, in particular due to the adhesive force and / or cohesive force of the fluid 2.

[0275] The wettability (in particular the hydrophilic and / or polar characteristics) of the tube 25 and / or the immersion element 27 helps to bend the tube 25 according to the spatial orientation of the cartridge 3 or the gravity G, so that the tube 25 (in particular its tip or free end 25B) remains within the fluid 2, and / or so that the fluid connection from the fluid 2 in the cartridge 3 to the delivery mechanism 10 is maintained, preferably without being affected by any movement or change in the spatial orientation of the cartridge 3 or the nebulizer 1. Thus, even when the patient of the nebulizer 1 moves the nebulizer 1 during use, for example by rotating it to a horizontal position or even inverting it, the fluid 2 can be withdrawn from the cartridge 3.

[0276] In particular, due to the (attached) immersion element 27, the (outer and / or inner) surface area of the tube 25 and the contact surface between the tube 25 and the fluid 2 preferably increase at its free end 25B, in particular such that the adhesion effect is further enhanced.

[0277] In a most preferred embodiment (not shown), the free end 25B of the immersion / contact element 27 or the tube 25 can be funnel-shaped or conical. In particular, the inner diameter and / or outer diameter of the tube 25 can increase towards the free end 25B, preferably such that the tube 25 includes an increased contact surface at its tip.

[0278] Furthermore, the wettability (in particular hydrophilic and / or polar properties) of the optional connector 26 helps to avoid the formation of air bubbles on its inner surface. In particular, the inner surface of the connector 26 is easily wetted by the fluid 2, such that no air bubble accumulation occurs in the transition region between the connector 26 and the connection port 9.

[0279] The fluid 2 is preferably a polar fluid and / or includes a polar solvent, such as water. In particular, the fluid 2 or its components include polar molecules and / or a dipole moment. As described above, this supports the wettability of the tube 25 with the fluid 2, thus supporting the interaction between the surface of the tube 25 and the fluid 2. However, a non-polar fluid 2 can also be used.

[0280] Preferably, the contact angle between the droplets of the fluid 2 and the surface of the tube 25 and / or the immersion element 27 is less than 90° or 70°, in particular less than 50° or 30°, and particularly preferably less than 20° or 5°. According to a particularly preferred embodiment, the contact angle between the droplets of the fluid 2 and the surface of the tube 25 and / or the immersion element 27 is between 0° and 2°.

[0281] Optionally, the container 4 is less wettable than the tube 25 and / or includes at least a partially hydrophobic and / or non-polar (inner) surface or layer. According to such an embodiment, the container 4, in particular its (inner) surface or layer, can be coated with a hydrophobic and / or non-polar material and / or made of a hydrophobic and / or non-polar material. In this way, the wettability of the container 4 is reduced, such that less fluid 2 adheres to the (inner) surface or layer of the container 4. Thus, in a synergistic manner, the hydrophilic and / or polar tube 25 and the hydrophobic and / or non-polar container 4 contribute to increasing the volume of the fluid 2 that can be withdrawn from the cartridge 3.

[0282] For example, the container 4 can be made of polytetrafluoroethylene, wax (such as paraffin wax), etc. or coated with polytetrafluoroethylene, wax (such as paraffin wax), etc.

[0283] Preferably, the contact angle between the droplets of the fluid 2 and the surface of the container 4 is greater than 70° or 90°, in particular greater than 100° or 110°, and particularly preferably greater than 130° or 140°.

[0284] Figure 7 Shown is a tube 25 having a funnel-shaped and / or conical joint 26 remote from the connection port 9, and shown is the assembled state of the cartridge 3 before the tube 25 is press-fitted onto the connection port 9 to establish a liquid-tight and / or gas-tight connection or seal S4 between the two components, as previously described. The funnel and / or cone of the tube 25 / joint 26 allows the tube 25 to be sealingly connected to the connection port 9 and the connecting element 14.

[0285] In the following, other embodiments of the present invention will be described, where only the relevant differences or additional aspects will be emphasized. The previous explanations preferably additionally or in a similar manner apply and will result in similar features and advantages even if not repeated.

[0286] Figure 8 Shown is a cartridge 3 according to a second embodiment of the present invention. Figure 9 Shown is a schematic detail of the cartridge 3 in the region of the fixed end 25A of the tube 25.

[0287] As previously described, the cartridge 3, in particular the connection port 9 and / or the joint 26, is adapted to compensate for the length tolerances of the connecting element 14 and / or to sealingly receive connecting elements 14 of different lengths.

[0288] According to the second embodiment, the cartridge 3 preferably includes an intermediate member 29 to fluidly connect the tube 25 to the connecting element 14 (not shown in Figure 8 and Figure 9 ), preferably where the length tolerances of the connecting element 14 can be compensated for by the intermediate member 29, in particular by axially moving the intermediate member 29, which will be described below.

[0289] The intermediate member 29 is preferably arranged at the fixed end 25A of the tube 25 and / or within the joint 26.

[0290] In Figure 8 and Figure 9 the shown embodiment, the joint 26 and the tube 25 are two separate parts. However, the joint 26 and the tube 25 can also be formed as a single unit, as described in connection with Figures 3 to 7 the first embodiment shown.

[0291] Preferably, the intermediate member 29 is formed and / or configured to provide a transition / connection from the tube 25 to the connecting element 14. In particular, the intermediate member 29 is adapted to reduce the flow losses at the transition from the tube 25 to the connecting element 14.

[0292] Most preferably, the intermediate member 29 forms a (capillary) transition from the tube 25 to the connecting element 14, in particular in such a way that a continuous capillary is formed by the connecting element 14, the tube 25 and the intermediate member 29, i.e., without any capillary blockage and / or an enlarged flow area that causes an interruption of the capillary action. In this way, the fluid 2 can be drawn into the connecting element 14 by capillary action and / or without any capillary blockage.

[0293] The flow area (in particular the (minimum) inner diameter) of the intermediate member 29 is equal to and / or at least substantially matches the flow area (in particular the (minimum) inner diameter) of the tube 25 and the connecting element 14, in particular in order to form a continuous transition from the tube 25 to the connecting element 14 and / or to prevent the formation of air bubbles at the transition.

[0294] Preferably, the intermediate member 29 is adapted to reduce / minimize the enlargement of the flow area and / or to avoid any dead volume at the transition from the tube 25 to the connecting element 14.

[0295] Preferably, the (widest / largest) flow area at the transition from the tube 25 to the connecting element 14 (in particular at the transition from the tube 25 to the intermediate member 29 and / or from the intermediate member 29 to the connecting element 14) is at least substantially equal to and / or not greater than 120% of the (minimum or maximum) flow area of the connecting element 14, the tube 25 and / or the intermediate member 29.

[0296] Preferably, the (widest / largest) flow area at the transition from the tube 25 to the connecting element 14 (in particular at the transition from the tube 25 to the intermediate member 29 and / or from the intermediate member 29 to the connecting element 14) is less than 1 mm 2 or 0.30 mm 2 .

[0297] Most preferably, the intermediate member 29 and the tube 25 and / or the intermediate member 29 and the connecting element 14 can be (sealingly) inserted into each other. In Figure 8 and Figure 9 the embodiment shown, the intermediate member 29 is preferably insertable into the tube 25. However, the tube 25 can also be inserted into the intermediate member 29.

[0298] Preferably, the intermediate member 29 is configured as a piston or a plunger and / or includes or forms a stop 29A, preferably, wherein the intermediate member 29 is insertable into the tube 25 until the stop 29A hits the axial end (in particular the front surface) of the tube 25.

[0299] Preferably, at least one of the tube 25 and the intermediate member 29 is flexible / deformable / stretchable, in particular such that when the tube 25 is connected to the intermediate member 29, a transition with at least substantially a constant flow area is formed, as Figure 9 most clearly shown in

[0300] Preferably, the middleware 29 is rigid and the tube 25 is flexible, in particular stretchable, such that when the middleware 29 is inserted into the tube 25, the tube 25 expands.

[0301] Preferably, the middleware 29 includes a (flat) contact surface 29B for connecting the element 14, in particular where the contact surface 29B is arranged on a side remote from the tube 25.

[0302] Preferably, when the connecting element 14 is inserted into the connection port 9, the connecting element 14 axially impacts the middleware 29 (in particular its contact surface 29B), preferably such that the connecting element 14 (in particular its axial end) is flush with the middleware 29 (in particular its contact surface 29B) and / or forms a sealed connection. However, other solutions are also possible. In particular, the middleware 29 and the connecting element 14 can be (sealedly) inserted into each other as described previously in connection with the tube 25.

[0303] The middleware 29 is preferably adapted to compensate for the length tolerance of the connecting element 14. In particular, the middleware 29 can move axially relative to the tube 25 to compensate for the length tolerance of the connecting element 14.

[0304] In the delivery state, as Figure 8 and Figure 9 shown, the middleware 29 is preferably only partially inserted into the tube 25, in particular such that the middleware 29 can be further pushed into or onto the tube 25.

[0305] The delivery state should be understood as the state before the cartridge 3 is inserted into the sprayer 1.

[0306] Preferably, when the connecting element 14 is inserted into the connection port 9, the connecting element 14 impacts the middleware 29 (in particular its contact surface 29B), and / or the middleware 29 is (further) pushed into or moved into the tube 25 according to the axial length of the connecting element 14. In this way, the length deviation of the connecting element 14 can be compensated and / or a sealed connection can be provided between the connecting element 14 and the tube 25 without being affected by the length deviation of the connecting element 14.

[0307] The present invention allows, supports or ensures that the connecting element 14 is sealedly connected to the tube 25 at its axial end, in particular through the middleware 29 and / or is not affected by the possible length deviations of different connecting elements 14.

[0308] Furthermore, the connecting element 14 and the tube 25 form or include a continuous capillary and / or include at least a substantially constant flow area, in particular through the middleware 29. The possible entrapment of air bubbles and / or voids, gaps and / or (sharp) expansions of the flow area at the transition from the tube 25 to the connecting element 14 that may cause capillary blockage are minimized or prevented, in particular such that a continuous capillary transition is formed.

[0309] Figure 10 A cartridge 3 according to a third embodiment of the invention is shown. Figure 11 Shown according to Figure 10 Schematic detail of the cartridge 3 in the region of the free end 25B of the tube 25 . Figure 12 Shows something like Figure 11 Schematic detail of , but the cartridge 3 and / or the tube 25 and / or the free end 25B are in a different spatial orientation.

[0310] In the third embodiment, the immersion element 27 is preferably arranged around the tube 25 and / or surrounds or covers the tube 25 .

[0311] Preferably, the immersion element 27 does not surround or cover the entire length of the tube 25. In particular, the tube 25 comprises a portion 25C which is not surrounded or covered by the immersion element 27 or does not include the immersion element 27 and another portion 25D which is surrounded or covered by the immersion element 27 or includes the immersion element 27.

[0312] The portion 25D preferably comprises the free end 25B or is adjacent to the free end 25B of the tube 25. The portion 25C preferably comprises the fixed end 25A or is adjacent to the fixed end 25A. However, other solutions are also possible, such as the immersion element 27 being located in the middle of the tube 25. Solutions in which a plurality of immersion elements 27 are distributed along the entire length of the tube 25 or a portion thereof are also possible.

[0313] exist Figure 10 In the embodiment of the present invention, the immersion element 27 preferably has a conical shape and / or tapers towards the free end 25B of the tube 25. However, other shapes are also possible, such as an at least substantially cylindrical shape or the like.

[0314] Figure 10 Shown in Figure 5 The cartridge 3, which is similarly positioned to be connected to the delivery mechanism 10, is in a rotated or horizontal position, i.e., such that the remaining fluid 2 no longer accumulates at the bottom or axially lower end of the container 4, but rather accumulates at the longitudinal sides of the container 4 due to gravity G. However, the preferred normal operating position of the cartridge 3 and / or the nebulizer 1 according to the third embodiment is a position in which the remaining fluid 2 accumulates at the bottom or axially lower end (not shown) of the container 4, as in the previous embodiments.

[0315] In the normal operating position, the tube 25 is at least substantially straight and / or has no (high) bends, with the free end 25B being close to the bottom of the container 4 so as to be immersed in the fluid 2 even if the container 4 is almost empty.

[0316] When tipping, the tube 25 preferably bends so that the free end 25B remains immersed in the fluid 2 .

[0317] In particular, only the portion 25C of the tube 25 that is not surrounded by the immersion element 27 and / or adjacent to the fixed end 25A is bendable and / or flexible. The portion 25D of the tube 25 surrounded by the immersion element 27 is preferably not bendable and / or is rigid or inflexible and / or is prevented from bending by the immersion element 27. This is shown in Figure 10 as Figure 10 shows the cartridge 3 in a horizontal position, where the surrounded portion 25D is not bent and the other portion 25C is bent due to the gravity G and / or the wettability of the tube 25 and / or the immersion element 27.

[0318] Preferably, the immersion element 27 of the third embodiment has similar characteristics to the immersion element 27 described in connection with the first embodiment, in particular being wettable by the fluid 2 and / or having a higher surface tension than the fluid 2, and / or having a greater density than the fluid 2, such that the free end 25B remains immersed in the fluid 2.

[0319] Preferably, the surface of the immersion element 27 is hydrophilic and / or polar and / or has a higher surface tension than the fluid 2. Together with the preferably hydrophobic and / or non-polar inner surface of the container 4 and / or the bag 5, this ensures that the immersion element 27 and the inner surface do not come into direct contact with each other and / or stick together.

[0320] In particular, the immersion element 27 can be surface-treated, for example, to achieve hydrophilic characteristics as described in connection with the first embodiment.

[0321] Preferably, the immersion element 27 is made of plastic, in particular a plastic material with a density higher than that of water, such as polytetrafluoroethylene, polysiloxane, etc. However, the immersion element 27 can also be made of other materials, such as metal, ceramic, etc.

[0322] The length of the immersion element 27 and / or the portion 25D surrounded by the immersion element 27 is preferably greater than the length of the portion 25C not surrounded by the immersion element 27, in particular greater than 2 times and / or less than 10 times. The immersion element 27 preferably covers or surrounds more than 60% and / or less than 90% of the tube 25.

[0323] Preferably, the length of the immersion element 27 exceeds the diameter of the cartridge 3.

[0324] The wall thickness of the tube 25 or the bendable portion 25C is preferably selected to be thin enough to allow the bendable portion 25C to bend sufficiently. Preferably, the wall thickness is less than 0.2 mm, in particular less than 0.15 mm, and particularly preferably less than 0.12 mm and / or greater than 0.05 mm, in particular greater than 0.08 mm.

[0325] The weight of the immersion element 27 according to the third embodiment preferably enables the desired bending characteristics of the tube 25 to be achieved. In particular, the weight of the immersion element 27 is determined by the length of the immersion element 27 or the corresponding tube sections 25C, 25D and / or the wall thickness of the tube 25.

[0326] In particular, the thicker the wall of the tube 25 and / or the shorter the bendable tube section 25C, the greater the weight of the immersion element 27 needs to be to achieve the same bending characteristics.

[0327] The preferred weight of the immersion element 27 according to the third embodiment is greater than 0.5 g, in particular greater than 0.8 g and / or less than 1.5 g, in particular less than 1.2 g, and particularly preferably at least substantially 1 g, in particular allowing the tube 25 with the aforementioned preferred wall thickness and / or tube section 25C length to bend sufficiently.

[0328] The immersion element 27 and the tube 25 are preferably connected in a tight-fitting manner, in particular such that no air or fluid 2 can be trapped between the tube 25 and the immersion element 27.

[0329] The tube 25 and the immersion element 27 are preferably formed as separate parts, in particular made of different materials, but can also be integrally formed or formed as a single unit.

[0330] The tube 25 or the immersion element 27 preferably includes a valve 30 that opens or closes according to the spatial orientation or position of the valve 30 and / or the tube 25. In Figures 10 to 12 the example shown, the valve 30 is located at or near the free end 25B of the tube 25. However, the valve 30 can also be located at the fixed end 25A or somewhere between the two ends.

[0331] The valve 30 is preferably configured such that it opens during normal operation or in the upright position of the cartridge 3 and / or the valve 30 and / or when the tube 25 is in at least a substantially unbent position. Preferably, the valve 30 remains open when the cartridge 3 and / or the valve 30 is tilted or rotated to a horizontal position or any position between the upright position and the horizontal position.

[0332] The valve 30 is preferably configured to close when the cartridge 3 and / or the valve 30 is in an inverted position or an inclined position between the horizontal position and the inverted position and / or when it cannot be ensured that the free end 25B of the tube 25 is immersed in the fluid 2.

[0333] For example, if the tube 25 and / or the immersion element 27 are adapted such that the rigid and / or not (sufficiently) bendable tube section 25D exceeds the inner diameter of the container 4, it is not possible for the tube 25 or its bendable part 25C to be bent by 90°, 120°, 150° or more, because the container wall restricts such movement. This also applies to very thin containers 4 whose diameter is small compared to their longitudinal extension length. In this case, the length of the tube 25 is much larger than the diameter of the container 4, such that the tube 25 may get stuck on the container wall in an inverted position. Similarly, when using the flexible tube 25 with the collapsible bag 5, the tube 25 may get stuck or squeezed at the fold of the bag 5.

[0334] In cases where it is not possible to bend the tube 25 due to the construction of the cartridge 3 such that its free end 25B is always immersed in the fluid 2, the valve 30 can be located at any position of the tube 25 (in particular its free end 25B or fixed end 25A), or it can also be located within the connector 26, the connection port 9 or the closure 7. An example is the case where the rigid tube section 25D exceeds the inner diameter of the container 4.

[0335] However, if the cartridge 3 is constructed such that the tube 25 can in principle reach any point within the container 4, the valve 30 is preferably arranged at or near the free end 25B. In this way, it is ensured that the opening and closing of the valve 30 do not depend on the orientation of the cartridge 3, but only on the orientation of the free end 25B. For example, in Figures 4 to 6 the cartridge 3 is shown in different spatial orientations, however, the free end 25B of the tube 25 always points in the direction of the gravity G, i.e., in the same spatial orientation in all three cases. In this orientation, the valve 30 is preferably open. However, if the free end 25B points in a direction at least substantially opposite to the gravity G, as Figure 12 exemplarily shown, the valve 30 is preferably closed. This preferably ensures that the valve 30 opens only when the free end 25B is immersed in the fluid 2.

[0336] In the following, the preferred construction of the valve 30 will be described in more detail. However, other structural solutions are also possible.

[0337] The valve 30 preferably includes a valve ball 30A that can move freely within the valve chamber 30B.

[0338] The valve ball 30A is preferably made of a material with a density greater than that of the fluid 2, in particular a plastic material, such that the valve wall 30A will sink into the fluid 2 due to the gravity G.

[0339] The diameter of the valve ball 30A is preferably larger than the inner diameter of the free end 25B and / or the tube 25, and the valve ball 30A is in particular adapted to close the free end 25B in at least a substantially inverted orientation of the valve 30 and / or the free end 25B.

[0340] The wall of the valve chamber 30B is preferably formed by the immersion element 27.

[0341] Preferably, the tube 25 or its free end 25B is fluidly connected to the valve chamber 30B.

[0342] The wall of the valve chamber 30B preferably includes an opening or an inlet, particularly an inlet at its axial end and a lateral inlet 28 in the side wall. The diameter of the inlet is preferably smaller than the diameter of the valve ball 30A such that the valve ball 30A cannot leave the valve chamber 30B.

[0343] Preferably, the opening of the chamber 30B is arranged such that not all of the inlets can be simultaneously closed by the valve ball 30A. This preferably ensures that at least one inlet remains open regardless of the spatial orientation of the valve 30.

[0344] Optionally, the valve chamber 30B can be at least substantially cage-shaped, particularly the wall of the valve chamber 30B (preferably on all sides) is grid-shaped and the valve ball 30A is confined within the cage-shaped valve chamber 30B. This preferably ensures that the valve chamber 30B is filled with the fluid 2 when submerged.

[0345] Figure 12 The valve 30 is shown in an inverted position, i.e., the free end 25B of the tube 25 points in the direction of gravity G and / or is not necessarily submerged in the fluid 2. In this case, the valve ball 30A preferably rests on the free end 25B, thereby closing the free end 25B, i.e., the inlet of the tube 25. In particular, the valve ball 30A located on the free end 25B prevents air from entering the tube 25.

[0346] Figures 13 to 18 The cartridge 3 according to the fourth embodiment of the present invention is shown. The drawing shows the cartridge 3 schematically, with one side of the container 4 removed such that the interior of the container 4 is visible.

[0347] In the fourth embodiment of the present invention, the tube 25 is preferably at least substantially or partially shaped as a helix, particularly a cylindrical helix as shown in Figures 13 to 15 or a conical helix according to Figure 17 and Figure 18 . However, other helical shapes of the tube 25 are also possible, for example, a double-conical shape that is X-shaped in a cross-sectional view, where the diameter of the helix first decreases and then increases again, as shown in Figure 16 .

[0348] Preferably, the tube 25 has the same or similar characteristics as the tube 25 described in connection with the foregoing embodiments, particularly the tube 25 is at least substantially flexible and / or wettable and / or has a constant inner diameter. The tube 25 may also include a submersion element 27.

[0349] The helix and / or the tube 25 are preferably adapted such that the free end 25B is always submerged in the fluid 2, particularly such that the free end 25B is located in a position close to the liquid surface.

[0350] In particular, the helix is compressible and / or stretchable, and / or the height of one complete turn of the helix measured parallel to the helix axis (also known as the helix pitch) can be changed. Thus, the axial length of the helix is adaptable, in particular the helix can be stretched and / or compressed by changing the pitch.

[0351] Preferably, the helical portion immersed in the fluid 2 is compressed at least substantially as much as possible, and / or the pitch of the immersed helical portion is at least substantially zero, and / or the helical portion immersed in the fluid 2 is at least substantially planar, especially if the immersion element 27 is not provided.

[0352] The compression of the immersed helical portion is preferably achieved by the buoyancy force exerted by the fluid 2 on the portion of the helix or tube 25 immersed in the fluid 2 (thus pushing the portion upwards). However, the helix or tube 25 is adapted not to float on the fluid 2, but to be (slightly) immersed such that the free end 25B of the tube 25 is below the liquid level, but preferably close to the liquid level.

[0353] Preferably, the pitch of the helix is at least substantially constant over the length of the helical portion not immersed in the fluid 2. The helical portion immersed in the fluid 2 preferably also has a constant pitch, which can, however, be different from (in particular smaller than) the pitch of the helical portion not immersed in the fluid 2. Thus, preferably, the pitch changes at the liquid level. However, other solutions are possible where the pitch is constant over the entire length of the helix or where the pitch varies over the entire length of the helix (e.g., the pitch increases or decreases from the fixed end 25A to the free end 25B).

[0354] Particularly preferably, the axial length of the helix depends on or is adjusted to the liquid level of the fluid 2 and / or the height of the filling level in the container 4. Figure 14 An example is shown of a higher liquid level and / or more fluid 2 being accommodated in the container 4. In this case, as Figure 13 shown, the helix (in particular the helical portion not immersed in the fluid 2) is compressed more and / or has a smaller pitch than when the liquid level in the container 4 is lower and / or there is less fluid 2.

[0355] When the immersion element 27 is provided, especially at or near the free end 25B, the helix, tube 25 and / or free end 25B are preferably immersed deeper in the upright position than when there is no immersion element 27 and / or are not close to the liquid level and / or are closer to the bottom of the container 4. This is shown in Figure 15 this.

[0356] The deeper immersion of the helix, tube 25 and / or free end 25B is preferably due to the additional weight of the immersion element 27 counteracting the buoyancy force of the fluid 2.

[0357] Particularly preferably, the geometry and / or weight of the immersion element 27 is adapted such that the desired immersion depth of the helix, tube 25 and / or free end 25B is obtained. In particular, the greater the weight and / or the smaller the volume of the immersion element 27, the greater the immersion depth.

[0358] Particularly preferably, the tube 25 has the shape of a conical helix, i.e. a helix shape in which the helix diameter measured perpendicular to the helix axis continuously decreases or increases along said axis. In particular, the interior of the helix is conical and / or the tube 25 has a shape like being wound around a cone. This preferred conical shape of the helix is as Figure 17 and Figure 18 shown.

[0359] Preferably, the conical helix has fewer windings or turns than a cylindrical helix, particularly preferably about half the number of windings or turns.

[0360] Preferably, the helix has a minimum diameter at the fixed end 25A, a maximum diameter at the free end 25B and / or tapers from the free end 25B towards the fixed end 25A. However, the helix can also taper towards the free end 25B and / or have a minimum diameter at the free end 25B and a maximum diameter at the fixed end 25A.

[0361] In addition, other solutions with non-constant diameters are also possible here, where the maximum and / or minimum diameter is neither at the free end 25B nor at the fixed end 25A, for example Figure 16 shown double conical shape, the minimum diameter of which is at least substantially at half the length of the helix or tube 25.

[0362] The diameter of the helix at its widest point is preferably at least 5% or 10% smaller than the diameter of the container 4.

[0363] The helix or tube 25 is preferably compressible into at least substantially two-dimensional or flat helix. This is achieved in particular by the preferred conical shape, which allows the helix or tube 25 to become at least substantially two-dimensional or flat helix when maximally compressed. In contrast, when a cylindrical helix is maximally compressed, the tube walls collide with each other, so that the shape remains cylindrical and thus three-dimensional or non-flat.

[0364] Preferably, the helix and / or tube 25 is adapted such that the free end 25B is always immersed in the fluid 2, even when the cartridge 3 is not in an upright position.

[0365] In particular, the helix or tube 25 is bendable and / or can be bent towards the fluid 2, for example in the horizontal position of the cartridge 3 or container 4, as explained in the previous embodiments.

[0366] In addition, the compressibility of the helix or tube 25 allows the helix or tube 25 to adjust its length such that the free end 25B remains immersed in the fluid 2. This preferably prevents the helix or tube 25 from getting stuck on the wall of the container 4 or the bag 5, and / or helps to keep the free end 25B immersed in the fluid 2 in the tilted position of the cartridge 3 or the container 4.

[0367] The helix or tube 25 is preferably adapted such that when the cartridge 3 or the container 4 is in a tilted position and / or when the helix or tube 25 is bent, its windings do not get stuck to each other. In particular, for a helical shape having a maximum diameter at or near the free end 25B, such as the preferred conical shape, the free end 25B can more easily adapt to the position or level of the fluid 2. This is preferably due to the fact that the free end 25B is at a certain distance from the other parts of the tube 25, thus preventing it from getting stuck, for example, in the next winding of the helix.

[0368] Particularly preferably, when the cartridge 3 is in at least a substantially inverted position, due to the gravity G and / or the wettability of the tube 25, the helix is compressible and / or invertible. For the preferred conical shape, this is shown in Figure 18 FIG.

[0369] For a non-conical shape, when inverted, the helix or tube 25 becomes or is maximally compressed, and / or the pitch of the helix is as small as possible, in particular at least substantially zero (not shown).

[0370] For the preferred conical shape, as Figure 18 shown, when inverted, the helix or tube 25 flips or is flipped, and / or the tube 25 has a helical shape but in the opposite direction, coiling or extending from the fixed end 25A towards the closure 7 or the top of the cartridge 3 or the container 4. In this case, the pitch of the helix can be different from the pitch in the upright position, but it can also be the same.

[0371] Preferably, in the inverted position, the helix and / or the tube 25 spiral around the connection port 9 and / or the connector 26.

[0372] In the inverted position, the free end 25B is preferably located near the top or the axial upper end of the cartridge 3 or the closure 7. Thus, it is ensured that the free end 25B always remains immersed in the fluid 2.

[0373] Preferably, the helix or tube 25 flips or is flipped at least partially at the position of the cartridge 3 between the horizontal position and the inverted position. This ensures that the free end 25B also remains immersed in the fluid 2 at these positions.

[0374] Generally, the free end 25B of the tube 25 can always at least substantially form the lowest point of the tube 25, regardless of the orientation of the cartridge 3.

[0375] Figure 19Shows a cartridge 3 according to a fifth embodiment of the present invention.

[0376] According to the fifth embodiment, the cartridge 3 preferably includes a movable element or piston 35. Specifically, the piston 35 is axially movable and / or movable within the container 4.

[0377] According to the fifth embodiment, the container 4 preferably has an opening at its bottom or axial lower end, which is closed by the piston 35.

[0378] In particular, in the delivery state and / or before any fluid 2 is withdrawn from the cartridge 3 or the container 4, the piston 35 is in an initial (lower) position. Preferably, in the initial position, the piston 35 is located near the base of the container 4 or the axial end opposite the closure 7. The volume defined by the container 4, the closure 7, and the piston 35 in the initial position is preferably or defines the maximum filling volume of the container 4.

[0379] Preferably, the container 4 or the piston 35 is provided with a piston seal 36, which acts between the piston 35 and the inner wall of the container 4, in particular to seal the piston 35 inside the container 4 in a liquid-tight and / or gas-tight manner. The piston seal 36 can be formed as a ring or lip and / or held by the piston 35. However, other construction solutions are also possible.

[0380] When withdrawing the fluid 2, the piston 35 preferably moves axially towards the closure 7, as Figure 19 shown moving upwards. Specifically, Figure 19 shows the cartridge 3 in a state where a portion of the fluid 2 has been withdrawn from the cartridge 3 and / or the piston 35 has moved upwards.

[0381] Preferably, the cartridge 3 according to the fifth embodiment does not include or does not require a ventilation / breathing feature 6. In this case, withdrawing the fluid 2 from the cartridge 3 creates a low pressure inside the container 4, thereby creating a pressure difference between the inside and outside of the container 4. This pressure difference preferably causes the piston 35 to move, in particular such that the volume defined by the closure 7, the container 4, and the piston 35 decreases. Therefore, the piston 35 preferably moves towards the closure 7 until pressure compensation between the inside and outside of the container 4 is achieved.

[0382] Specifically, the piston 35 occupies a new axial position within the container 4 and remains in this new axial position until the fluid 2 is withdrawn again.

[0383] Preferably, the connection port 9 and / or the connector 26 do not extend deep into the interior of the container 4, such that the piston 35 can move at least substantially all the way to the closure 7 and / or at least substantially over the entire length of the container 4. In particular, the volume defined by the closure 7, the container 4, and the piston 35 can be reduced to at least substantially zero, such that almost all of the fluid 2 can be withdrawn from the cartridge 3.

[0384] Particularly preferably, the cartridge 3 according to the fifth embodiment further includes a tube 25. In particular, the fixed end 25A of the tube 25 is close to the top or the axial upper end of the container 4, so that the connection port 9 and / or the adapter 26 do not extend deep into the interior of the container 4.

[0385] The free end 25B of the tube 25 is preferably fixed or attached to the piston 35. Specifically, the tube 25 is fastened to the piston 35 at or near the free end 25B by a fastener 37, such as a bracket or a clamp. However, other solutions are also possible, such as integrating the tube 25 into the piston 35.

[0386] Preferably, the tube 25 is funnel-shaped or conical at or near its free end 25B. In particular, the outer diameter of the tube 25 can increase towards the free end 25B.

[0387] The fastener 37 is preferably located at a part of the tube 25 having a constant outer diameter. In this way, the free end 25B having a larger outer diameter cannot break away from the fastener 37, so that the tube 25 is attached to the piston 35 in a form-fitting manner by the fastener 37.

[0388] Preferably, the tube 25 is attached to the piston 35 such that the free end 25B is at least substantially parallel and / or close to the surface of the piston 35 facing the closure 7.

[0389] In particular, the free end 25B is always located and / or the fluid 2 is always withdrawn from the bottom or the axial lower end of the volume containing the fluid 2. This is particularly advantageous when withdrawing the fluid 2 from the cartridge 3 in an upright position.

[0390] Particularly preferably, the tube 25 has a spiral shape as described in connection with the fourth embodiment, and particularly preferably a conical spiral shape.

[0391] As already explained in connection with the fourth embodiment, the spiral is preferably compressible, and when maximally compressed, the conical spiral can particularly preferably become or form at least substantially flat or two-dimensional spiral.

[0392] The compressibility of the spiral or the tube 25 is particularly advantageous for the movable piston 35. When the piston 35 moves towards the closure 7, the spiral or the tube 25 is preferably compressed to an increasing extent. Therefore, the axial length of the spiral or the tube 25 is adjustable, or particularly automatically adjusted to the distance between the closure 7 and the piston 35 and / or the axial length of the volume containing the fluid 2. This ensures that the piston 35 can move within the container 4 without being blocked or hindered by the tube 25 before reaching the end position.

[0393] The piston 35 is preferably in its end position when the helix or tube 25 is maximally compressed. Further movement of the piston 35 is then blocked by the helix or tube 25, and / or no further fluid 2 can be withdrawn from the container 4. In this regard, a conical helix is particularly advantageous because when maximally compressed, it becomes at least substantially flat, thus occupying a minimum axial space within the container 4. Thus, in a cartridge 3 with a conical helix, the piston 35 can move at least substantially along the entire axial length of the container 4, and / or at least substantially all of the fluid 2 can be withdrawn from the cartridge 3.

[0394] Figure 20 Figure 3 shows a cartridge 3 according to a sixth embodiment of the present invention.

[0395] According to the sixth embodiment, the cartridge 3 includes a preferably flexible / collapsible bag 5 for containing the fluid 2, preferably where the bag 5 is arranged or held within the container 4, as described in connection with Figure 1 and Figure 2 and further includes a flexible / bendable tube 25.

[0396] Preferably, the venting / breathing feature 6 is arranged at the bottom or lower axial end of the container 4. In this way, it is preferably ensured that the collapsible bag 5 separates from the container 4 starting from the lower axial end and / or collapses starting from the lower axial end. In particular, in this case, the venting / breathing feature 6 is an indirect gas connection. Thus, a sterile filter is not required, but such a filter can be provided additionally.

[0397] The tube 25, particularly its free end 25B, preferably does not include an immersion element 27. This preferably increases the mobility of the tube 25 and / or prevents or reduces jamming or pinching of the tube 25, particularly at the fold of the bag 5. However, an immersion element 27 can also be provided for the tube 25, particularly preferably an enclosing immersion element 27 as described in connection with Figure 10 described.

[0398] Preferably, the bag 5 is less wettable than the tube 25 and / or includes at least a partially hydrophobic and / or non-polar (inner) surface. In this case, the bag 5 (particularly its (inner) surface) can be coated with a hydrophobic and / or non-polar material and / or made of a hydrophobic and / or non-polar material. In this way, the wettability of the bag 5 is reduced, such that optionally less fluid 2 may adhere to the (inner) surface of the bag 5. Thus, in a synergistic manner, the hydrophilic and / or polar tube 25 and the hydrophobic and / or non-polar bag 5 contribute to increasing the volume of fluid 2 that can be withdrawn from the cartridge 3.

[0399] For example, the bag 5 can be made of or coated with polytetrafluoroethylene, wax (such as paraffin wax), etc.

[0400] Preferably, the contact angle between the droplets of the fluid 2 and the surface of the bag 5 is greater than 70° or 90°, in particular greater than 100° or 110°, and particularly preferably greater than 130° or 140°.

[0401] Figures 21 to 23 The cartridge 3 according to the seventh embodiment of the invention is shown. Figure 21 The cartridge 3 is shown before being connected to the delivery mechanism 10 and / or having a closed or intact seal 8, foil 8A and / or diaphragm or sealing wall 31. Figure 22 The cartridge 3 is shown when connected to the delivery mechanism 10 and / or having an opened or punctured seal 8, foil 8A and / or diaphragm or sealing wall 31. Figure 23 It is a schematic detail of the diaphragm or sealing wall 31 in a closed or intact state.

[0402] Features not directly related to the tube 25 described in connection with the seventh embodiment, such as features of the diaphragm or sealing wall 31, radial sealing of the connecting element 14, etc., can also preferably be implemented independently of the tube 25. In this case, as Figure 1 and Figure 2 shown, the connecting element 14 is immersed in the fluid 2 when connected to the cartridge 3.

[0403] Regarding the features of the tube 25, particularly its connection to the connecting element 14, the seventh embodiment is similar to Figure 8 and Figure 9 shown in the second embodiment. Therefore, only the relevant differences or additional aspects will be emphasized. The previous explanations, particularly those related to the second embodiment, are preferably additionally or similarly applied, and will result in similar features and advantages even without repetition. However, other explanations, features and advantages of other embodiments can also be achieved, such as the wettability of the tube 25, its shape, etc.

[0404] According to the seventh embodiment of the invention, the intermediate member 29 is preferably integrally formed with the tube 25. In particular, the fixed end 25A includes or forms the intermediate member 29.

[0405] The fixed end 25A or the intermediate member 29 preferably includes a contact surface 29B for the connecting element 14, which is arranged on the side facing away from the tube 25 and / or towards the top of the cartridge 3.

[0406] Preferably, the intermediate member 29 or the fixed end 25A can move axially relative to the closure 7, the connection port 9 and / or the joint 26 and / or within the closure 7, the connection port 9 and / or the joint 26. At least initially or in the delivery state, the fixed end 25A is preferably only fixed against radial movement. The delivery state should be understood as the state before the cartridge 3 is connected or inserted into the sprayer 1.

[0407] After the cartridge 3 has been connected to the delivery mechanism 10 of the nebulizer 1, the fixed end 25A is preferably also fixed against axial movement.

[0408] In particular, according to the seventh embodiment, the adapter 26 and the tube 25 are preferably formed as two separate parts such that the entire tube 25 together with the intermediate piece 29 integrally formed therewith is preferably axially movable relative to the closure 7, the connection port 9 and / or the adapter 26.

[0409] The intermediate piece 29, the fixed end 25A and / or the tube 25 are preferably adapted to compensate for the length tolerances of the connecting element 14.

[0410] In the delivered state or before the cartridge 3 is connected to the delivery mechanism 10 of the nebulizer 1, the intermediate piece 29, the fixed end 25A and / or the tube 25 are preferably arranged in an initial position in the adapter 26 or the connection port 9 that allows the intermediate piece 29, the fixed end 25A and / or the tube 25 to be further pushed downwards in the axial direction.

[0411] Preferably, the intermediate piece 29, the fixed end 25A and / or the tube 25 are held in the initial position by a (radial) press fit.

[0412] Preferably, the intermediate piece 29 or the fixed end 25A includes a stop 29A, especially on the side facing the tube 25 and / or away from the top of the cartridge 3. The connection port 9 or the adapter 26 preferably has a corresponding support surface 26B that limits the axial movement when the stop 29A hits the support surface 26B.

[0413] When the connecting element 14 is inserted and / or when the cartridge 3 is connected to the delivery mechanism 10 of the nebulizer 1, the connecting element 14 preferably hits the intermediate piece 29 or the fixed end 25A, especially its contact surface 29B, and / or pushes or moves the intermediate piece 29, the fixed end 25A and / or the tube 25 further downwards (i.e., towards the inside of the cartridge 3) in the axial direction depending on the axial length of the connecting element 14.

[0414] In this way, the length deviation of the connecting element 14 can preferably be compensated for.

[0415] Figure 22 The situation is shown where the tube 25 has been pushed or moved to the maximum extent and / or the stop 29A has hit the support surface 26B. However, it is also possible that the tube 25 is only partially or not at all pushed / moved downwards, especially as in Figure 22 the example shown when the connecting element 14 is shorter.

[0416] Regarding the compensation of the length tolerance of the connecting element 14, the main difference between the second and seventh embodiments is that in the second embodiment, the intermediate member 29 is formed as an independent part that can be inserted into the tube 25 or the like, while in the seventh embodiment, the intermediate member 29 is integrally formed with the tube 25 (especially its fixed end 25A). Therefore, in the seventh embodiment, the intermediate member 29 is preferably not pushed / moved relative to the tube 25, but the entire tube 25 together with the intermediate member 29 is pushed / moved relative to the connection port 9 or the fitting 26.

[0417] In other respects, the features and advantages described in connection with the second embodiment equally apply to the seventh embodiment. Particularly preferably, the features regarding the connecting element 14 and the tube 25 that form or include a continuous capillary and / or at least a substantially constant flow area described in connection with the second embodiment also apply to the cartridge 3 according to the seventh embodiment. In particular, the void or gap at the transition from the connecting element 14 to the tube 25 or the intermediate member 29 is minimized to prevent capillary blockage.

[0418] The following explanations, features, and advantages can also preferably be implemented independently of the tube 25, that is, they also apply to the cartridge 3 that does not have the tube 25, where the connecting element 14 is immersed in the fluid 2, as Figure 1 and Figure 2 shown. Therefore, the length of the connecting element 14 is preferably greater than the case where the tube 25 is additionally provided.

[0419] Preferably, the cartridge 3 includes a seal S1 between the closure 7 and the container 4 and / or the bag 5. In Figures 1 to 10 it, this seal S1 is shown as a sealing element 32 in the form of a sealing ring or the like, which particularly seals the cartridge 3 axially.

[0420] According to the seventh embodiment of the present invention, as Figure 21 and Figure 22 shown, preferably, such a sealing element 32 is arranged between the closure 7 and the container 4 and / or the bag 5 that axially extends into the container 4, and optionally can also radially project onto the opening edge of the container 4. In particular, the sealing element 32 is held or fixed between the closure 7 (especially the connection port 9) and the container 4 by a radial and / or axial press fit / tight fit. Particularly preferably, an airtight and / or liquidtight connection or seal S5 is formed between the sealing element 32 and the container 4, especially radially and / or axially.

[0421] Preferably, the sealing element 32 is funnel-shaped and / or conical and / or attached to the connection port 9. In particular, the sealing element 32 is flexible and / or adapted to sealingly receive the connection port 9 and / or the connecting element 14, especially its axial end, most preferably in a press fit / tight fit manner. Particularly preferably, a seal S4 is formed between the connection port 9 and the sealing element 32.

[0422] Preferably, the closure 7 includes a sealing element 32.

[0423] The sealing element 32 is preferably made of rubber, in particular nitrile rubber, butadiene rubber, styrene-butadiene rubber, isoprene rubber, styrene-isoprene rubber, butyl rubber, ethylene-propylene-diene monomer rubber, etc., and / or made of (flexible) plastic, in particular thermoplastic and / or thermoplastic elastomer, such as polyamide, polyethylene, polypropylene, polyurethane, polybutylene terephthalate or polyether block amide, etc. Other suitable materials can also be used.

[0424] Preferably, the cartridge 3 (in particular the connection port 9 and / or the sealing element 32) is adapted to receive the connection element 14 in a sealed manner (preferably its axial end and / or outer edge), in particular in a press fit / tight fit manner and / or such that a fluid and / or tight connection can be established between the cartridge 3 and the delivery mechanism 10.

[0425] In particular, the cartridge 3 has or forms a preferably cylindrical insertion opening for the connection element 14, the insertion opening having at least a substantially constant diameter, which diameter preferably corresponds to the diameter of the connection element 14. Preferably, the opening is formed by the closure 7, the connection port 9 and / or the sealing element 32. The opening can initially be covered or closed, in particular by one or more seals 8 (such as the foil 8A and / or the diaphragm or the sealing wall 31), which one or more seals 8 are adapted to be broken or pierced by the connection element 14 during insertion.

[0426] Preferably, the connection port 9 and / or the sealing element 32 are flexible and / or stretchable.

[0427] In particular, the connection element 14 is connected to the connection port 9 in a press fit manner (once inserted).

[0428] Most preferably, the connection element 14 expands the (flexible) connection port 9 (laterally), in particular such that a liquid-tight and / or airtight connection or seal S2 is formed between the connection port 9 and the connection element 14.

[0429] Additionally or alternatively, the connection element 14 (once inserted) is connected to the sealing element 32 in a sealed manner and / or in a press fit manner. In particular, the connection element 14 (preferably its axial end and / or its outer edge) expands the (flexible) sealing element 32, in particular such that a liquid-tight and / or airtight connection or seal S3 is formed between the connection element 14 (preferably its axial end and / or its outer edge) and the sealing element 32.

[0430] Preferably, before the connecting element 14 or its axial end is hermetically received by the sealing element 32 and / or forms the seal S3, it must pass through the connecting port 9, and in particular, it must also break or pierce the diaphragm or the sealing wall 31 (if provided).

[0431] Here, both the connecting port 9 and the sealing element 32 are connected to the connecting element 14 in a sealed and / or press-fitting manner. In other words, two sealing positions or seals S2, S3 are established with the connecting element 14: the first is between the side or the housing surface of the connecting element 14 and the connecting port 9, and the second is between the axial end of the connecting element 14 and the sealing element 32.

[0432] Preferably, in this case, when being inserted or received, the connecting element 14 first forms or establishes the seal S2 with the connecting port 9, and forms or establishes the seal S3 with the sealing element 32 after passing through the connecting port 9.

[0433] Particularly preferably, the connecting element 14 is radially sealed or sealingly connected by the sealing element 32 and / or the connecting port 9. Figure 22 Such (radial) seals S2, S3 between the connecting element 14 and the connecting port 9 or the sealing element 32 are shown. In particular, the seal S2 and / or S3 is achieved or formed by a press fit / tight fit of the connecting element 14 with the connecting port 9 and / or the sealing element 32.

[0434] In particular, the connecting port 9 and / or the sealing element 32 is at least partially flexible, deformable and / or stretchable, and has one or more portions with a diameter smaller than the outer diameter of the connecting element 14. When the connecting element 14 is inserted, the said portions can be bent / deformed / stretched such that the seals S2 and / or S3 are respectively formed between the connecting element 14 and the connecting port 9 and / or the sealing element 32 at the said one or more portions. Alternatively or additionally, the connecting element 14 can be (radially) flexible or deformable.

[0435] Particularly preferably, when inserted, the connecting element 14 stretches / deforms the connecting port 9 and / or the sealing element 32 such that the force applied to the sealing element 32 and / or the press fit / tight fit of the connecting port 9, the sealing element 32 and / or the container 4 is further increased.

[0436] Preferably, even when the connecting element 14 is axially moved, a seal S2 between the connecting element 14 and the connection port 9 and / or a seal S3 between the connecting element 14 and the sealing element 32 can be established, because the connecting element 14 is received and / or connected laterally / radially sealedly by the connection port 9 and / or the sealing element 32. In this way, during the insertion of the connecting element 14 and / or when connecting the cartridge 3 to the delivery mechanism 10 of the nebulizer 1, the S3 and S2 seals are also provided, in particular such that the fluid 2 can only flow out of the cartridge 3 through the connecting element 9.

[0437] The seal S2 is preferably formed or established at least substantially at the level of the diaphragm or the sealing wall 31 in the delivery state or in the connection port 9. In other words, when the connecting element 14 is inserted into the connection port 9, the seal formed by the diaphragm or the sealing wall 31 is preferably replaced by the seal S2.

[0438] Figure 22 Another seal S6 is shown, which is preferably formed or established after the cartridge 3 is inserted into the nebulizer 1. In particular, the seal S6 is located above the seal S2 (if provided) and / or near the top of the closure 7. The seal S6 can be formed between the closure 7 / connection port 9 and the connecting element 14, or as Figure 22 shown, formed between the closure 7 / connection port 9 and a part of the holder 11 of the nebulizer 1.

[0439] In the case where the cartridge 3 includes the tube 25, the sealing element 32 preferably forms or includes the joint 26. In particular, if the tube 25 is provided, the explanations, features and advantages described in connection with the joint 26 and the sealing element 32 in various embodiments are mutually applicable.

[0440] Preferably, the connecting element 14 is (further) sealedly connected to the tube 25, in particular to the fixed end 25A or the axial end of the intermediate piece 29, as described in connection with the second embodiment. However, if the S2 and / or S3 seals are provided, such a seal can also be omitted.

[0441] Preferably, the connection port 9 and the joint 26 / sealing element 32 are connected to each other by a press fit / tight fit, in particular forming a seal S4 therebetween. However, other solutions can also be provided here, for example, the connection port 9 and the joint 26 / sealing element 32 are integrally formed or formed as a whole. Optionally, the joint 26 / sealing element 32 can be connected to or held by the container 4, and the connection port 9 is located above or within the joint 26 / sealing element 32.

[0442] Particularly preferably, the connection port 9 and the joint 26 / sealing element 32 are connected or assembled, in particular by a press fit / tight fit, before being mounted on the container 4.

[0443] When installed on the container 4, the tube 25 can be integrated with and / or form a unit with the connection port 9 or the adapter 26 / sealing element 32. Alternatively, the connection port 9 and / or the adapter 26 / sealing element 32 are first installed on the container 4, and then the tube 25 is inserted into the container 4, particularly from the top.

[0444] Below, the diaphragm or sealing wall 31 preferably included in the cartridge 3 will be discussed in further detail.

[0445] The diaphragm or sealing wall 31 is preferably embodied as a diaphragm or septum. Preferably, the diaphragm or sealing wall 31 is integrated and / or arranged within the closure 7 or the connection port 9, particularly preferably at the end face of the closure 7 or the connection port 9 facing the adapter 26 / sealing element 32 or the tube 25 and / or facing away from the top of the cartridge 3.

[0446] Optionally, the diaphragm or sealing wall 31 can also be integrated, arranged within the adapter 26 / sealing element 32 and / or connected to the adapter 26 / sealing element 32. More than one diaphragm sealing wall 31 can also be provided, for example one arranged in the connection port 9 and one arranged in the adapter 26 / sealing element 32.

[0447] In the following description, it is assumed that the diaphragm or sealing wall 31 is arranged in the connection port 9. However, it will be apparent to those skilled in the art that the described features can be similarly implemented when the diaphragm or sealing wall 31 is arranged in the adapter 26 / sealing element 32.

[0448] The diaphragm or sealing wall 31 preferably forms a seal 8, particularly sealing the closure 7 or the connection port 9 relative to the fluid 2 accommodated in the container 4.

[0449] The shape of the diaphragm or sealing wall 31 preferably corresponds to the connecting element 14, particularly the diaphragm or sealing wall 31 is at least substantially circular or disc-shaped and / or has at least substantially a diameter equal to the outer diameter of the connecting element 14.

[0450] In the delivered state, the diaphragm or sealing wall 31 is preferably integrally formed with the closure 7 or the connection port 9 or formed as a single piece. Particularly preferably, the closure 7 or the connection port 9 and the diaphragm or sealing wall 31 are injection-molded as a single unit.

[0451] Preferably, the diaphragm or sealing wall 31 includes a center or raised portion 31A, an outer peripheral portion 31B, a connecting portion 31C and / or a diaphragm hinge 31D. The diaphragm or sealing wall 31 and / or the different portions 31A to 31D of the diaphragm or sealing wall 31 are preferably formed as a single piece, particularly by injection molding.

[0452] The central or raised portion 31A is preferably arranged at the center of the diaphragm or sealing wall 31 and / or embodied as a thickened portion of the diaphragm or sealing wall 31. The raised portion 31A is preferably formed as a dome or spherical portion. In particular, the central or raised portion 31A is arranged on the side of the diaphragm or sealing wall 31 facing the tube 25 and / or facing away from the top of the cartridge 3.

[0453] Particularly preferably, the diaphragm or sealing wall 31 is at least substantially flat on the side facing the top of the cartridge 3 and / or is curved or convex on the opposite side, in particular due to the provision of the raised portion 31A on said side.

[0454] In the delivery state, the outer peripheral portion 31B preferably connects the diaphragm or sealing wall 31 to the connection port 9. In particular, in the delivery state, the outer peripheral portion 31B forms a ring or part of a ring that integrally connects the diaphragm or sealing wall 31 to the connection port 9.

[0455] The outer peripheral portion 31B is preferably arranged at least partially along the outer periphery of the diaphragm or sealing wall 31. In particular, only the outer peripheral section of the diaphragm or sealing wall 31 including the connecting portion 31C and / or the membrane hinge 31D does not include the outer peripheral portion 31B.

[0456] The outer peripheral portion 31B is preferably implemented to be very thin and / or forms a predetermined break point of the diaphragm or sealing wall 31.

[0457] Preferably, the thickness of the outer peripheral portion 31B is less than 0.1 mm or 0.05 mm.

[0458] The connecting portion 31C is preferably formed as a web-like shape or formed as a ridge or reinforcing rib. In particular, the connecting portion 31C extends from the center of the diaphragm or sealing wall 31 and / or the raised portion 31A to the connection port 9. Particularly preferably, the connecting portion 31C forms a bridging member or additional connection from the connection port 9 to the center of the diaphragm or sealing wall 31 or the raised portion 31A.

[0459] In particular, preferably, in addition to being (integrally) connected by the outer peripheral portion 31B, the diaphragm or sealing wall 31 is also (integrally) connected to the connection port 9 by the connecting portion 31C.

[0460] The connecting portion 31C is preferably integrally formed with the raised portion 31A, the diaphragm or sealing wall 31, and / or the connection port 9.

[0461] Particularly preferably, the connecting portion 31C and / or the raised portion 31A is ten or twenty times thicker than the outer peripheral portion 31B.

[0462] When manufacturing the connection port 9 and / or the diaphragm or the sealing wall 31, in particular by injection molding, the connecting portion 31C preferably forms a bridge or an additional connection from the connection port 9 towards the center of the diaphragm or the sealing wall 31. The connecting portion 31C preferably bridges the outer peripheral portion 31B, in particular such that the molding material (in particular molded plastic) can be injected or flow via the connecting portion 31C into the center of the diaphragm or the sealing wall 31, thereby forming the central or raised portion 31A. In particular, the material can cross the outer peripheral portion 31B through the connecting portion 31C. This ensures that the outer peripheral portion 31B can be formed as thin as desired, since it is not necessary for the material to be injected or flow through the outer peripheral portion 31B during the injection molding process.

[0463] The diaphragm or the sealing wall 31 or the connecting portion 31C preferably forms or includes a membrane hinge 31D. In particular, the diaphragm or the sealing wall 31 can swing or articulate deviatingly by means of the membrane hinge 31D.

[0464] When the cartridge 3 is connected to the delivery mechanism 10 of the nebulizer 1, the connecting element 14 is preferably inserted into the connection port 9, in particular from the top of the cartridge 3.

[0465] The connecting element 14 is preferably adapted to penetrate or pierce the diaphragm or the sealing wall 31.

[0466] Preferably, the closure 7 or the connection port 9 includes an opening for inserting the connecting element 14. The opening preferably has a funnel-shaped or conical portion which aligns or guides the connecting element 14 to the diaphragm or the sealing wall 31. Specifically, the connecting element 14 is positioned and / or configured such that it can pierce or break the diaphragm or the sealing wall 31 in a defined or precise manner.

[0467] When the connecting element 14 is pushed onto the diaphragm or the sealing wall 31 and / or inserted into the connection port 9, the diaphragm or the sealing wall 31 preferably breaks or tears along the outer peripheral portion 31B or adapts thereto.

[0468] The central / raised portion 31A, the connecting portion 31C and / or the membrane hinge 31D preferably remain intact and / or do not tear or rupture when the connecting element 14 presses against the diaphragm or the sealing wall 31 or when the connecting element is inserted into the connection port 9. In particular, during and after the insertion of the connecting element 14 into the connection port 9, the diaphragm or the sealing wall 31 remains connected to the connection port 9 by the membrane hinge 31D.

[0469] When the connecting element 14 is pushed against the diaphragm or the sealing wall 31, or during the connection of the cartridge 3 to the delivery mechanism 10 or its adaptation thereto, the diaphragm or the sealing wall 31 preferably swings, articulates or tilts to one side.

[0470] Particularly preferably, the diaphragm or the sealing wall 31 is swung, tilted or hinged into the recess 9A formed by the connection port 9 or the adapter 26 / sealing element 32. Preferably, after the cartridge 3 is connected to the delivery mechanism 10 or in the operating state of the nebulizer 1, the diaphragm or the sealing wall 31 remains tilted to one side and / or within the recess 9A, as Figure 22 shown.

[0471] Particularly preferably, the diaphragm or the sealing wall 31 is arranged in the connection port 9 and / or the adapter 26 / sealing element 32 so as to be inclined with respect to the longitudinal axis of the connection port 9, the adapter 26 / sealing element 32 or the connection element 14. Specifically, the longitudinal axis is non-perpendicular or non-orthogonal to the main extension plane of the diaphragm or the sealing wall 31. In particular, in the upright position of the cartridge 3, the main extension plane of the diaphragm or the sealing wall 31 is not horizontal.

[0472] Preferably, the diaphragm or the sealing wall 31 is inclined such that the membrane hinge 31D is at least substantially at the lowest point of the diaphragm or the sealing wall 31 in the upright position of the cartridge 3. In particular, the membrane hinge 31D is the point on the diaphragm or the sealing wall 31 closest to the tube 25 and / or the point furthest from the top or the closure 7 of the cartridge 3.

[0473] When the connection element 14 is inserted into the cartridge 3, the connection element 14 preferably first contacts or pushes the point on the diaphragm or the sealing wall 31 that is at least substantially opposite to the membrane hinge 31D. This is especially due to the inclined arrangement of the diaphragm or the sealing wall 31, and the said point opposite to the membrane hinge 31D is the highest point of the diaphragm or the sealing wall 31 and / or the point closest to the top or the closure 7 of the cartridge 3.

[0474] Preferably, the diaphragm or the sealing wall 31 or the outer peripheral portion 31B starts to tear or rupture at the highest point or the point opposite to the membrane hinge 31D. In particular, the outer peripheral portion 31B at or near the said point can be formed as the thinnest part of the diaphragm or the sealing wall 31.

[0475] When the connection element 14 is further pushed downwards, the diaphragm or the sealing wall 31 preferably tears further along the entire outer peripheral portion 31B and hinges open, preferably while still being connected to the connection port 9 via the membrane hinge 31D.

[0476] The diaphragm or the sealing wall 31 preferably tears along the outer peripheral portion 31B and tilts to one side in a defined manner and / or tilts to one side or adapts thereto in a reproducible manner for similarly manufactured cartridges 3. In particular, for similarly manufactured cartridges 3, the force required to break the diaphragm or the sealing wall 31 is at least substantially the same.

[0477] This preferably ensures that when the cartridge 3 is connected to the delivery mechanism 10, the diaphragm or sealing wall 31 does not obstruct or affect the connecting element 14, the fixed end 25A of the tube 25, and / or the delivery mechanism 10. In particular, the diaphragm or sealing wall does not tear completely and / or remains connected to the connection port 9 and / or remains in the recess 9A via the membrane hinge 31D.

[0478] The connection port 9 (in particular its end face) may further include a step or notch 9B located near the membrane hinge 31D, particularly as Figure 23 shown. The notch 9B may form the recess 9A or a part thereof. In particular, the notch 9B enables the diaphragm or sealing wall 31 to be or more easily tilted or hinged to one side.

[0479] The cartridge 3 according to the seventh embodiment of the present invention preferably further includes a housing 33. The housing 33 preferably covers the container 4 and / or the closure 7. Specifically, the container 4 and / or the closure 7 are arranged within the housing 33.

[0480] Preferably, the housing 33 has an opening at the top, particularly for inserting the connecting element 14 into the cartridge 3. In the delivery state, the opening is preferably covered by a seal 8 (particularly a foil 8A).

[0481] The housing 33 preferably includes a ventilation / breathing feature 6 (not shown), such as a valve, an opening, or a hole, preferably at the bottom of the cartridge 3.

[0482] Preferably, the housing 33 is rigid and / or made of metal, particularly aluminum. However, other solutions are also possible here, such as a plastic housing 33.

[0483] The housing 33 preferably has an (outer peripheral) notch or groove 33A, particularly which extends or protrudes into the recess formed between the container 4 and the closure 7. The groove 33A preferably forms the neck of the cartridge 3.

[0484] The holder 11 of the atomizer 1 preferably includes an engagement portion 11A corresponding to the groove 33A. The engagement portion 11A is preferably flexible and / or formed as a flexible arm. In particular, when the cartridge 3 is connected to the holder 11 of the atomizer 1 or the delivery mechanism 10, the engagement portion 11A can engage with the groove 33A. The cartridge 3 is preferably held or fixed in the atomizer 1 in a press-fit and / or form-fit manner by the engagement portion 11A engaging with the groove 33A.

[0485] Preferably, the cartridge 3, the container 4, and / or the bag 5 are sealed by the closure 7, particularly by the sealing elements 32 and / or the seals S1, S4, and S5 between the closure 7, the connection port 9, the adapter 26, the sealing element 32, and / or the container 4.

[0486] In the delivered state, the cartridge 3, the container 4 and / or the bag 5 are preferably further sealed by one or more seals 8 (in particular the foil 8A and / or the diaphragm or the sealing wall 31).

[0487] When the cartridge 3 is connected to the delivery mechanism 10, the connecting element 14 preferably breaks or pierces the one or more seals 8, and a (new) seal S2 and / or S3 is established between the connecting element 14 and the closure 7, the connection port 9, the joint 26 and / or the sealing element 32. Thus, when the cartridge 3 has been connected to the delivery mechanism 10 or in the operating state of the nebulizer 1, the cartridge 3, the container 4 and / or the bag 5 are preferably sealed by the seals S1 to S5.

[0488] Preferably, the cartridge 3 includes another seal S7 between the closure 7 and the housing 33. In particular, an airtight and / or liquidtight connection is formed between the closure 7 and the housing 33.

[0489] Particularly preferably, the seal S7 between the closure 7 and the housing 33 is formed by or includes a sealing member 34.

[0490] The seal S7 or the seal 34 preferably seals the cartridge 3 radially.

[0491] The seal 34 is preferably in the form of a ring, a gasket or a molded seal. The seal 34 is preferably located in a peripheral recess or groove of the closure 7. The closure 7 and the sealing member 34 may also be integrally formed, particularly preferably by two-component injection molding.

[0492] The housing 33 may have a protrusion or notch 33B that projects towards, abuts against and / or presses against the closure 7 and / or the sealing member 34, in particular to provide or increase the press fit / tight fit between the housing 33 and the closure 7 and / or the sealing member 34, particularly preferably thereby forming the seal S7.

[0493] The seal S7 or the seal 34 preferably seals the cartridge 3 from the environment. Thus, even if the fluid 2 has leaked from the container 4, it is possible to prevent the fluid 2 from leaking from the cartridge 3, in particular through the connection between the container 4 and the closure 7 and / or through the ventilation / breathing feature 6.

[0494] Particularly preferably, leakage of the fluid 2 from the container 4 has been prevented, in particular by providing a seal or a sealing between the container 4 and the closure 7 as described above. However, the sealing element 34 or the seal S7 is preferably additionally provided, and / or as a fail-safe device, such that even if the fluid 2 has leaked from the container 4, it cannot leak from the cartridge 3 or the housing 33.

[0495] Preferably, at least the container 4 and the adapter 26 / sealing element 32 are at least substantially resistant to evaporation or diffusion. In particular, the seal formed by the sealing element 32 not only prevents leakage of the fluid 2 but also prevents (long-term) evaporation or diffusion of the fluid 2. Thus, the cartridge 3 is preferably storage-stable and / or can be stored for a longer time without significant loss of the fluid 2.

[0496] Particularly preferably, the other parts of the cartridge 3, in particular the closure 7, the connection port 9, the housing 33 and / or the sealing member 34, are at least substantially resistant to evaporation or diffusion. However, in particular, the parts that are not in direct contact with the fluid 2 can be made of materials that are less resistant to evaporation / diffusion.

[0497] The present invention allows, supports or ensures that the fluid 2 can be withdrawn from the cartridge 3 at any spatial position in the cartridge 3, and / or even the fluid 2 with a low remaining volume can be withdrawn from the cartridge 3, such as less than 0.1 ml, 0.05 ml or 0.01 ml. Thus, due to the present invention, the total amount of the dose that can be dispensed is increased and / or improper use or incorrect administration of the nebulizer 1 can be prevented, or at least the risk of such improper use or incorrect administration can be reduced.

[0498] The individual features, aspects and / or principles of the different embodiments described can be implemented independently of each other and can also be combined with each other in any combination as needed, and can be particularly used in the nebulizer 1 shown, but can also be used in similar or different nebulizers / dispensing devices.

[0499] Different from a stand-alone device etc., the proposed nebulizer 1 is preferably designed to be portable and in particular a mobile manually-operated device.

[0500] However, the proposed solution can be used not only for the nebulizer 1 specifically described here but also for other nebulizers or inhalers or other devices for delivering liquid formulations.

[0501] Preferably, the fluid 2 is a liquid, as described above, in particular an aqueous pharmaceutical formulation or an ethanol pharmaceutical formulation, in particular having polar characteristics. However, the fluid 2 can also contain other pharmaceutical formulations, suspensions, etc., preferably water-based.

[0502] The preferred components and / or formulations of the preferred pharmaceutical fluid 2 are particularly listed in WO 2009 / 115200 A1, preferably on pages 25 to 40, or in paragraphs 0040 to 0087 of EP 2 614 848 A1, which are incorporated herein by reference. In particular, these can be aqueous solutions or non-aqueous solutions, mixtures, formulations containing ethanol or without any solvent, etc.

[0503] Different embodiments and their features and aspects can be combined as needed, but can also be implemented independently of each other.

[0504] In summary, the present invention includes but is not limited to the following technical items:

[0505] 1. A cartridge (3) for a nebulizer (1) for atomizing a fluid (2),

[0506] wherein the fluid (2) is a pharmaceutical composition / formulation and / or a liquid medicament,

[0507] The cartridge (3) comprises:

[0508] a container (4) for containing the fluid (2) to be atomized,

[0509] a tube (25) for delivering the fluid (2) out of the container (4), the tube (25) being at least partially flexible and / or bendable, and

[0510] a closure (7) having a connection port (9) for fluidly and / or sealingly connecting the container (4) to the nebulizer (1) or its delivery mechanism (10),

[0511] In particular, the tube (25) is mechanically and / or fluidly connected - preferably directly or indirectly - to the closure (7) or the connection port (9),

[0512] Characterized in that,

[0513] the tube (25) is at least partially capable of being wetted by the fluid (2) such that the tube (25) is at least partially immersed in the fluid (2), and / or

[0514] the tube (25) is at least partially helically shaped, and / or

[0515] the cartridge (3) comprises an adapter (26) connecting the tube (25) to the connection port (9), wherein the adapter (26) is adapted to sealingly receive the connection port (9) and / or the connection element (14) of the nebulizer (1), and / or form a sealing element (32) between the closure (7) or the connection port (9) and the container (4).

[0516] 2. The cartridge according to item 1, characterized in that the closure (7), in particular the connection port (9), holds and / or forms the axial / fixed end (25A) of the tube (25) in the central region of the container (4), and / or is fluidly and / or sealingly connected to the tube (25).

[0517] 3. The cartridge according to any one of the preceding items, characterized in that the tube (25) is configured as a capillary and / or has an inner diameter of less than 1 mm or 0.8 mm, in particular less than 0.7 mm or 0.5 mm, and / or greater than 0.1 mm or 0.2 mm.

[0518] 4. The cartridge according to item 3, characterized in that the tube (25) is configured such that in the delivery state of the cartridge (3) and / or when the cartridge (3) is opened, the tube (25) is at least partially immersed in the fluid (2) and / or the liquid level inside the tube (25) is equal to or higher than the liquid level outside the tube (25).

[0519] 5. The cartridge according to any one of the preceding items, characterized in that the tube (25) is shorter than the height of the container (4) and / or is in particular completely arranged inside the container (4), preferably such that its free end (25B) can reach the outermost regions of the container (4), in particular the axially upper end and the axially lower end of the container (4).

[0520] 6. The cartridge according to any one of the preceding items, characterized in that the tube (25) is made of plastic, preferably a thermoplastic and / or a thermoplastic elastomer, in particular polyamide, polyethylene, polypropylene, polybutylene terephthalate or polyether block amide.

[0521] 7. The cartridge according to any one of the preceding items, characterized in that the tube (25) is surface-treated, in particular by corona, plasma or flame treatment and / or coated to increase its surface energy.

[0522] 8. The cartridge according to any one of the preceding items, characterized in that the tube (25) contains at least one additive to increase its surface energy.

[0523] 9. The cartridge according to any one of the preceding items, characterized in that the surface energy of the tube (25) is greater than or equal to the surface tension of the fluid (2).

[0524] 10. The cartridge according to any one of the preceding items, characterized in that the tube (25) can be wetted by the fluid (2) such that the contact angle between the droplets of the fluid (2) and the surface of the tube (25) is less than 70° or 60°, in particular less than 50° or 30°, and most preferably less than 20°.

[0525] 11. The cartridge according to any one of the preceding items, characterized in that the cartridge (3) includes a submersion element (27) attached to or formed by the tube (25).

[0526] 12. The cartridge according to item 11, characterized in that the submersion element (27) is attached to or formed by the free end (25B) of the tube (25).

[0527] 13. The cartridge according to item 11, characterized in that the immersion element (27) has a tubular or conical shape and at least partially surrounds the tube (25).

[0528] 14. The cartridge according to any one of items 11 to 13, characterized in that the immersion element (27) is adapted such that at least the free end (25B) of the tube (25) is held in the fluid (2).

[0529] 15. The cartridge according to any one of items 11 to 14, characterized in that the surface energy of the immersion element (27) is greater than or equal to the surface tension of the fluid (2).

[0530] 16. The cartridge according to any one of the foregoing items, characterized in that the container (4), in particular its inner surface, is not wettable by the fluid (2) and / or is less wettable by the fluid (2) than the tube (25).

[0531] 17. The cartridge according to any one of the foregoing items, characterized in that the surface energy of the container (4), in particular its inner surface, is less than the surface energy of the tube (25) and / or less than the surface tension of the fluid (2).

[0532] 18. The cartridge according to any one of the foregoing items, characterized in that the contact angle between the surface of the container (4) and a droplet of the fluid (2) is greater than 70° or 90°, preferably greater than 100° or 110°, in particular greater than 130° or 140°, and / or greater than the contact angle between the surface of the tube (25) and a droplet of the fluid (2).

[0533] 19. The cartridge according to any one of the foregoing items, characterized in that the tube (25) or its immersion element (27) comprises at least a partially hydrophilic and / or polar surface, preferably where the fluid (2) is aqueous and / or comprises an aqueous solution and / or water as a solvent.

[0534] 20. The cartridge according to any one of the foregoing items, characterized in that the container (4) comprises at least a partially hydrophobic and / or non-polar inner surface or layer, preferably where the fluid (2) is aqueous and / or comprises an aqueous solution and / or water as a solvent.

[0535] 21. The cartridge according to any one of the foregoing items, characterized in that the fluid (2) contains at least one additive, in particular benzalkonium chloride, to reduce its surface tension.

[0536] 22. The cartridge according to any one of the foregoing items, characterized in that the helix is a conical helix and / or tapering, preferably towards its fixed end (25A).

[0537] 23. The cartridge according to any one of the preceding items, characterized in that the maximum diameter of the helix, in particular the diameter of its free end (25B), is at least 5% or 10% smaller than the inner diameter of the container (4).

[0538] 24. The cartridge according to any one of the preceding items, characterized in that the helix is compressible and / or the axial length of the helix can be adapted according to the level of the fluid (2), and / or the cartridge (3) comprises a piston (35) capable of moving within the container (4), preferably, the free end (25B) of the helix or tube (25) is attached or fastened to the piston (35).

[0539] 25. The cartridge according to any one of the preceding items, characterized in that for any spatial orientation of the cartridge (3), in particular even when inverted, the free end (25B) of the helix or tube (25) is at least substantially located at or adjacent to the lowest point of the fluid (2) within the container (4), and / or the helix or tube (25) is invertible, in particular such that the free end (25B) of the helix or tube (25) is at least substantially the lowest point of the helix or tube (25) when inverted.

[0540] 26. The cartridge according to any one of the preceding items, characterized in that the density of the tube (25) and / or its immersion element (27) is greater than the density of the fluid (2), in particular by 10%, 25% or 50%.

[0541] 27. The cartridge according to any one of the preceding items, characterized in that the axial / fixed end (25A) and / or the free end (25B) of the tube (25) comprises a valve (30), which is designed to open or close automatically according to the spatial orientation of the valve (30) and / or the free end (25B).

[0542] 28. The cartridge according to item 27, characterized in that the valve (30) closes when the free end (25B) is not immersed in the fluid (2) and / or at least substantially points in a direction opposite to the direction of gravity (G), and otherwise opens.

[0543] 29. The cartridge according to any one of the preceding items, characterized in that the fluid (2) has polar characteristics and / or is an aqueous pharmaceutical formulation or an alcohol-containing pharmaceutical formulation, in particular an ethanol pharmaceutical formulation.

[0544] 30. The cartridge (3) of the atomizer (1), preferably according to any one of the preceding items, comprising:

[0545] a container (4) for containing the fluid (2) to be atomized,

[0546] a closure (7) having a connection port (9) for fluidly and / or sealingly connecting the container (4) to the atomizer (1) or its delivery mechanism (10),

[0547] Characterized in that,

[0548] The closure (7) or connection port (9) includes a diaphragm or sealing wall (31), which has a membrane hinge (31D) and a peripherally reduced thickness portion (31B), such that when the connecting element (14) of the nebulizer (1) is inserted, the diaphragm or sealing wall (31) tears along the peripherally reduced thickness portion (31B) and tilts to one side, and / or

[0549] The cartridge (3) includes a sealing element (32) located between the closure (7) and the container (4) for forming a seal (S1) therebetween, wherein the sealing element (32) is adapted to sealingly receive the connecting element (14) after passing through the connection port (9), and / or

[0550] The cartridge (3) includes a tube (25) for delivering the fluid (2) out of the container (4) and a connector (26) connecting the tube (25) to the closure (7) or connection port (9).

[0551] 31. The cartridge according to item 30, characterized in that the diaphragm or sealing wall (31) and the closure (7)

[0552] or the connection port (9) are integrally formed.

[0553] 32. The cartridge according to item 30 or 31, characterized in that the closure (7), connection port (9), connector (26) and / or sealing element (32) includes or forms a recess (9A) for receiving the diaphragm or sealing wall (31) when it tilts to one side.

[0554] 33. The cartridge according to any one of items 30 to 32, characterized in that the diaphragm or sealing wall (31) includes a preferably ribbed connecting portion (31C) with an increased thickness, which connects the center of the diaphragm or sealing wall (31) to the closure (7) or connection port (9).

[0555] 34. The cartridge according to any one of items 30 to 33, characterized in that the main extension plane of the diaphragm or sealing wall (31) is inclined relative to the longitudinal axis of the closure (7), connection port (9) and / or connecting element (14) in the closed or unbroken state.

[0556] 35. The cartridge according to item 34, characterized in that the diaphragm or sealing wall (31) is inclined such that the membrane hinge (31D) is located at or forms the point farthest from the opening of the cartridge (3), closure (7) and / or connection port (9), which opening is preferably for inserting the connecting element (14).

[0557] 36. The cartridge according to item 36, characterized in that the diaphragm or the sealing wall (31) is located between the seal (S2) formed between the connection port (9) and the connection element (14) and the seal (S3) formed between the sealing element (32) and the connection element (14).

[0558] 37. The cartridge according to any one of items 30 to 36, characterized in that the connector (26) forms or comprises the sealing element (32), or vice versa.

[0559] 38. The cartridge according to any one of the preceding items, characterized in that the closure (7), in particular the connection port (9), extends into the interior of the container (4) and / or is made of rubber, in particular butyl rubber, and / or (flexible) plastic.

[0560] 39. The cartridge according to any one of the preceding items, characterized in that the closure (7) is sterile.

[0561] 40. The cartridge according to any one of the preceding items, characterized in that the cartridge (3) or its container (4)

[0562] comprises a venting / breathing feature (6), in particular a valve, an opening or a hole, and / or a sterile filter.

[0563] 41. The cartridge according to any one of the preceding items, characterized in that the cartridge (3) comprises a preferably flexible / collapsible bag (5) which houses the fluid (2), wherein the bag (5) is arranged or held within the container (4).

[0564] 42. The cartridge according to any one of the preceding items, characterized in that the connector (26) and / or the sealing element (32) is adapted to receive the connection port (9) and / or the connection element (14) in a sealed manner, in particular its axial end, preferably in a press / tight fit manner, in an axially movable manner and / or in a manner of forming a continuous capillary and / or capillary transition from the tube (25) to the connection element (14).

[0565] 43. The cartridge according to any one of the preceding items, characterized in that the connector (26) and / or the sealing element (32) is adapted to compensate for the length tolerance of the connection element (14) and / or to establish or form a seal (S3) with the connection element (14), in particular its axial end, regardless of

[0566] the length deviation of the connection element (14).

[0567] 44. The cartridge according to any one of the preceding items, characterized in that the connector (26) and / or the sealing element (32) is formed by the tube (25), in particular its fixed end (25A).

[0568] 53. The cartridge according to any one of the preceding items, characterized in that the adapter (26) and / or the sealing element (32) is / are adapted to receive the tube (25) in a sealed manner, and / or the axial / fixed end (25A) of the tube (25) is / are adapted to be connected to the adapter (26) and / or the sealing element (32) in a sealed manner.

[0569] 54. The cartridge according to any one of the preceding items, characterized in that the cartridge (3) comprises an intermediate member (29), in particular a rigid one, for fluidly connecting the tube (25) to the connecting element (14).

[0570] 55. The cartridge according to item 54, characterized in that the intermediate member (29) is adapted to form a capillary transition from the tube (25) to the connecting element (14), and / or the flow area, in particular the inner diameter, of the intermediate member (29) at least substantially matches the flow area, in particular the inner diameter, of the tube (25), preferably so as to form a continuous capillary and / or capillary transition from the tube (25) to the connecting element (14).

[0571] 56. The cartridge according to item 54 or 55, characterized in that the intermediate member (29) and the tube (25) are in particular capable of being inserted into each other in a sealed manner.

[0572] 57. The cartridge according to item 54 or 55, characterized in that the intermediate member (29) is integrally formed with the tube (25).

[0573] 58. The cartridge according to any one of items 54 to 57, characterized in that the intermediate member (29) is adapted to compensate for the length tolerance of the connecting element (14), and / or the intermediate member (29) can be axially moved, in particular axially pushed, by the connecting element (14) into, onto or with the tube (25), preferably so as to compensate for the length tolerance of the connecting element (14).

[0574] 59. The cartridge according to any one of the preceding items, characterized in that the tube (25) is at least partially flexible and / or bendable and / or made of rubber, in particular butyl rubber, and / or plastic, preferably a thermoplastic and / or a thermoplastic elastomer, in particular polyamide, polyethylene, polypropylene, polybutylene terephthalate or polyether block amide.

[0575] 60. The cartridge according to any one of the preceding items, characterized in that the tube (25) is longer than the container (4).

[0576] 61. The cartridge according to any one of the preceding items, characterized in that the tube (25) is longer than the container (4).

[0577] is short in height and / or is arranged entirely within the container (4), in particular, such that its free end (25B) can reach the outermost regions of the container (4), in particular the axially upper and axially lower ends of the container (4).

[0578] 53. The cartridge according to any one of the preceding items, characterized in that the closure (7), in particular the connection port (9), extends into the interior of the container (4) and / or holds and / or forms the axial / fixed end (25A) of the tube (25) in the central region of the container (4).

[0579] 54. An atomizer (1) for a fluid (2), comprising:

[0580] a preferably insertable cartridge (3) having a container (4) for receiving the fluid (2),

[0581] a housing (20) for receiving the cartridge (3),

[0582] a delivery mechanism (10) for pressurizing the fluid (2), and

[0583] a connection element (14) for fluidly connecting the cartridge (3) to the delivery mechanism (10),

[0584] wherein the cartridge (3) includes a tube (25) for delivering the fluid (2) out of the container (4),

[0585] characterized in that

[0586] the connection element (14) and the tube (25) form or include at least a substantially constant flow area, in particular at or including the transition from the tube (25) to the connection element (14), and / or

[0587] the connection element (14) is sealingly connected to the tube (25) at its axial end or axially abuts the tube (25), and / or

[0588] the cartridge (3) is constructed according to any one of the preceding items.

[0589] 55. The atomizer according to item 54, characterized in that the cartridge (3) includes a closure (7) having a seal (8), in particular a foil (8A) and / or a diaphragm or a sealing wall (31), and / or a preferably funnel-shaped and / or conical connection port (9), preferably, wherein the foil (8A) covers the connection port (9) leading to the outside, and / or the diaphragm or the sealing wall (31) is arranged within the connection port (9).

[0590] 56. The atomizer according to item 55, characterized in that the connecting element (14) is rigid and / or configured as a piercing element and / or adapted to pierce and / or open the cartridge (3), in particular the seal (8), the foil (8A) and / or the diaphragm or the sealing wall (31).

[0591] 57. The atomizer according to item 55 or 56, characterized in that the closure (7) and / or the connection port (9)

[0592] is adapted to form a seal (S2) with the connecting element (14).

[0593] 58. The atomizer according to any one of items 54 to 57, characterized in that the cartridge (3) comprises a preferably funnel-shaped and / or conical adapter (26) for fluidly connecting the tube (25) to the connecting element (14) and / or the connection port (9).

[0594] 59. The atomizer according to item 58, characterized in that the adapter (26) is adapted to sealingly receive the connection port (9) and / or the connecting element (14), in particular its axial end, preferably in a press / fit manner, in an axially movable manner and / or in a manner of forming a continuous capillary and / or capillary transition from the tube (25) to the connecting element (14).

[0595] 60. The atomizer according to item 58 or 59, characterized in that the adapter (26) is adapted to compensate for the length tolerance of the connecting element (14) and / or establish or form a sealed connection or a seal (S3) with the connecting element (14), in particular its axial end, regardless of the length deviation of the connecting element (14).

[0596] 61. The atomizer according to any one of items 58 to 60, characterized in that the adapter (26) is formed by the tube (25)

[0597] in particular its fixed end (25A).

[0598] 62. The atomizer according to any one of items 58 to 60, characterized in that the adapter (26) is adapted to sealingly receive the tube (25), and / or the axial / fixed end (25A) of the tube (25) is adapted to be connected to the adapter (26) in a sealed manner.

[0599] 63. The atomizer according to any one of items 54 to 62, characterized in that the cartridge (3) comprises in particular a rigid intermediate member (29) for fluidly connecting the tube (25) to the connecting element (14).

[0600] 64. The atomizer according to item 63, characterized in that the intermediate piece (29) forms a capillary transition from the tube (25) to the connecting element (14), and / or the flow area of the intermediate piece (29), in particular the inner diameter, at least substantially matches the flow area, in particular the inner diameter, of the tube (25) and the connecting element (14), preferably so as to form a continuous capillary and / or capillary transition from the tube (25) to the connecting element (14).

[0601] 65. The atomizer according to item 63 or 64, characterized in that the intermediate piece (29) and the tube (25) and / or the intermediate piece (29) and the connecting element (14) can in particular be inserted into each other in a sealed manner.

[0602] 66. The atomizer according to item 63 or 64, characterized in that the intermediate piece (29) is integrally formed with the tube (25).

[0603] 67. The atomizer according to any one of items 63 to 66, characterized in that the intermediate piece (29) is adapted to compensate for the length tolerance of the connecting element (14), and / or the intermediate piece (29) can be axially moved, in particular axially pushed, by the connecting element (14) into or onto the tube (25) or move together with the tube (25), preferably so as to compensate for the length tolerance of the connecting element (14).

[0604] 68. The atomizer according to any one of items 54 to 67, characterized in that the tube (25) is at least partially flexible and / or bendable and / or made of rubber, in particular butyl rubber, and / or plastic, preferably thermoplastic and / or thermoplastic elastomer, in particular polyamide, polyethylene, polypropylene, polybutylene terephthalate or polyether block amide.

[0605] 69. The atomizer according to any one of items 54 to 68, characterized in that the tube (25) is shorter than the height of the container (4) and / or is in particular completely arranged within the container (4), preferably such that its free end (25B) can reach the outermost regions of the container (4), in particular the axially upper end and the axially lower end of the container (4).

[0606] The atomizer according to any one of items 54 to 69, characterized in that the closure (7), in particular the connection port (9), extends into the interior of the container (4) and / or holds and / or forms the axial / fixed end (25A) of the tube (25) in the central region of the container (4).

[0607] List of reference signs:

[0608] 1 Atomizer 29 Intermediate piece

[0609] 2 Fluid 29A Stop

[0610] 3 Cartridge 29B Contact Surface

[0611] 4 Container 30 (Tube) Valve

[0612] 5 Bag 30A Valve Ball

[0613] 6 Venting / Permeability Feature 30B Valve Chamber

[0614] 7 Closure 31 Diaphragm / Sealing Wall

[0615] 8 (Pierceable) Seal 31A Projection

[0616] 8A Foil 31B Outer Periphery

[0617] 9 Connection Port 31C Connection Portion

[0618] 9A Recess 31D Membrane Hinge

[0619] 9B Notch 32 Sealing Element

[0620] 10 Delivery Mechanism 33 Housing

[0621] 11 Holder 33A Notch

[0622] 11A Engagement Portion 33B Recess

[0623] 12 Drive Spring 34 Sealing Member

[0624] 13 Blocking Element 35 Piston

[0625] 14 Connecting Element 36 Piston Seal

[0626] 15 Check Valve 37 Fastener

[0627] 16 Pressure Chamber

[0628] 17 Nozzle

[0629] 18 Mouthpiece A Aerosol

[0630] 19 Supply Opening G Gravity 20 Housing S1 Seal (Container - Closure) 21 Upper Housing Portion S2 Seal (Connection Port – 22 Lower Housing Portion Connection Element)

[0631] 23 Inner Housing Portion S3 Seal (Connecting Element - 24 Piercing Element Joint / Sealing Element)

[0632] 25-tube S4 seal (connection port – 25A fixed-end joint / sealing element)

[0633]

Claims

1. Cartridge (3) of a nebulizer (1), said nebulizer (1) comprising a delivery mechanism (10) and a connecting element (14) for fluidly connecting the cartridge (3) to said delivery mechanism (10), said cartridge (3) comprising: a container (4) for containing the fluid (2) to be atomized, a closure (7) having a connection port (9) for fluidly and / or sealingly connecting the container (4) to the nebulizer (1) or its delivery mechanism (10), a frangible diaphragm or sealing wall (31) arranged within the closure (7), characterized in that the cartridge (3) comprises a sealing element (32) located between the closure (7) and the container (4) for forming a seal (S1) therebetween, wherein the sealing element (32) is adapted to sealingly receive the connecting element (14) after it has passed through the connection port (9).

2. The cartridge according to claim 1, characterized in that, The diaphragm or sealing wall (31) is pierceable and is integrated within the closure (7).

3. The cartridge according to claim 1, characterized in that, The diaphragm or sealing wall (31) has a membrane hinge (31D) and a peripherally reduced thickness portion (31B) such that when the connecting element (14) of the nebulizer (1) is inserted, the diaphragm or sealing wall (31) tears along the peripherally reduced thickness portion (31B) and tilts to one side.

4. The cartridge according to claim 1, characterized in that, The sealing element (32) is fixed between the closure (7) and the container (4) by a radial and / or axial press fit.

5. The cartridge according to claim 1 or 4, characterized in that, The sealing element (32) projects radially onto the opening edge of the container (4).

6. The cartridge according to claim 1 or 4, characterized in that, The sealing element (32) is made of rubber and / or thermoplastic and / or thermoplastic elastomer.

7. The cartridge according to claim 1 or 4, characterized in that, The sealing element (32) is made of nitrile rubber, butadiene rubber, styrene-butadiene rubber, isoprene rubber, styrene-isoprene rubber, butyl rubber, ethylene-propylene-diene monomer rubber, polyamide, polyethylene, polypropylene, polyurethane, polybutylene terephthalate or polyether block amide.

8. The cartridge according to claim 1, characterized in that, The diaphragm or sealing wall (31) is formed integrally with the closure (7) or the connection port (9).

9. The cartridge according to claim 1 or 3, characterized in that, The closure (7), connection port (9) and / or sealing element (32) comprise a recess (9A) for receiving the diaphragm or sealing wall (31) when it tilts to one side.

10. The cartridge according to claim 1 or 3, characterized in that, The closure (7), connection port (9) and / or sealing element (32) form a recess (9A) for receiving the diaphragm or sealing wall (31) when it tilts to one side.

11. The cartridge according to claim 1 or 8, characterized in that, The diaphragm or sealing wall (31) comprises a centrally thickened ridge connection portion (31C) connecting the center of the diaphragm or sealing wall (31) to the closure (7) or the connection port (9).

12. The cartridge according to claim 1 or 8, characterized in that, The main extension plane of the diaphragm or sealing wall (31) is inclined relative to the longitudinal axis of the closure (7), connection port (9) and / or connecting element (14) in the closed or unbroken state.

13. The cartridge according to claim 12, characterized in that, The diaphragm or sealing wall (31) is inclined and has a membrane hinge (31D) such that the membrane hinge (31D) is located at or forms the point furthest from the opening of the closure (7) and / or connection port (9) for inserting the connecting element (14).

14. The cartridge according to claim 13, characterized in that, The diaphragm or sealing wall (31) is located between a seal (S2) formed between the connection port (9) and the connection element (14) and a seal (S3) formed between the sealing element (32) and the connection element (14).

15. The cartridge according to claim 1, characterized in that, The cartridge (3) includes a tube (25) for delivering the fluid (2) out of the container (4) and a fitting (26) connecting the tube (25) to the closure (7) or the connection port (9).

16. The cartridge according to claim 15, characterized in that, The sealing element (32) includes the fitting (26).

17. The cartridge according to claim 15, characterized in that, The sealing element (32) forms the fitting (26).

18. The cartridge according to claim 1, characterized in that, The connection port (9) extends into the interior of the container (4) and / or is made of rubber or flexible plastic.

19. The cartridge according to claim 1, characterized in that, The closure (7) is sterile.

20. The cartridge according to claim 1, characterized in that, The cartridge (3) or its container (4) includes a breathable feature and / or a sterile filter.

21. The cartridge according to claim 1, characterized in that, The cartridge (3) or its container (4) includes a venting feature, and the venting feature is an opening.

22. The cartridge according to claim 1, characterized in that, The cartridge (3) or its container (4) includes a venting feature, and the venting feature is a hole.

23. The cartridge according to claim 1, characterized in that, The cartridge (3) includes a flexible bag (5) that houses the fluid (2), and the bag (5) is arranged within the container (4).

24. The cartridge according to claim 1, characterized in that, The cartridge (3) includes a collapsible bag (5) that houses the fluid (2), and the bag (5) is held within the container (4).

25. The cartridge according to claim 15, characterized in that, The fitting (26) and / or the sealing element (32) is adapted to sealingly receive the connection port (9) and / or the connection element (14) in a press-fit manner.

26. The cartridge according to claim 15, characterized in that, The fitting (26) is adapted to sealingly receive the axial end of the connection element (14) to form a continuous capillary and / or capillary transition from the tube (25) to the connection element (14).

27. The cartridge according to claim 15, characterized in that, The fitting (26) and / or the sealing element (32) is formed by the tube (25).

28. The cartridge according to claim 15, characterized in that, The fitting (26) and / or the sealing element (32) is adapted to sealingly receive the tube (25), and / or the axial fixed end (25A) of the tube (25) is adapted to be connected to the fitting (26) and / or the sealing element (32) in a sealed manner.

29. The cartridge according to claim 15, characterized in that, The tube (25) is at least partially flexible and / or is made of rubber or thermoplastic or thermoplastic elastomer.

30. The cartridge according to claim 15, characterized in that, The tube (25) is made of butyl rubber, polyamide, polyethylene, polypropylene, polybutylene terephthalate, or polyether block amide.

31. The cartridge according to claim 15, characterized in that, The tube (25) is entirely arranged within the container (4) such that its free end (25B) can reach the outermost region of the container (4).

32. The cartridge according to claim 15, characterized in that The connection port (9) extends into the interior of the container (4) and / or holds and / or forms the axial fixed end (25A) of the tube (25) in the central region of the container (4).

33. An atomizer (1) for a fluid (2), comprising: a cartridge (3) having a container (4) that houses the fluid (2), a housing (20) for receiving the cartridge (3), a delivery mechanism (10) for pressurizing the fluid (2), and a connection element (14) for fluidly connecting the cartridge (3) to the delivery mechanism (10), characterized in that the cartridge (3) is constructed according to claim 1.

34. The atomizer according to claim 33, characterized in that, The cartridge (3) is insertable into the atomizer (1).

35. The sprayer according to claim 33, characterized in that, The connection port (9) is funnel-shaped and / or conical, and / or the diaphragm or sealing wall (31) is arranged within the connection port (9).

36. The atomizer according to claim 33 or 35, characterized in that, The cartridge (3) includes a closure (7) having a foil (8A), where the foil (8A) covers the connection port (9) leading to the outside.

37. The atomizer according to claim 36, characterized in that, The connection element (14) is rigid.

38. The atomizer according to claim 36, characterized in that, The connection element (14) is configured as a piercing element.

39. The atomizer according to claim 36, characterized in that, The connection element (14) is adapted to open the foil (8A) and / or the diaphragm or sealing wall (31).

40. The atomizer according to claim 33, characterized in that, The connection element (14) is rigid.

41. The atomizer according to claim 33, characterized in that, The connection element (14) is configured as a piercing element.

42. The sprayer according to claim 33, characterized in that, The connection element (14) is adapted to open the cartridge (3) and / or the diaphragm or sealing wall (31).

43. The atomizer according to any one of claims 40 - 42, characterized in that, The closure (7) and / or the connection port (9) is adapted to form a seal (S2) with the connection element (14).

Images