Multi-cavity intravenous injection set

Abstract

A multi-lumen intravenous infusion set comprises: an adapter comprising a main conduit and an auxiliary conduit; a valve housing comprising a housing port and a housing passage; a main lumen in fluid communication with the main conduit and the housing port; an auxiliary lumen in fluid communication with the auxiliary conduit and the housing port; and a valve disposed in the valve housing, the valve comprising a burst pressure, wherein the valve is configured to prevent fluid from flowing from the housing port to the housing passage when pressure on the valve is less than the burst pressure, and wherein the valve is configured to allow fluid to flow from the housing port to the housing passage when pressure on the valve is greater than the burst pressure.

Description

[0001] This application is a divisional application of the invention application with the application date of October 10, 2019, application number 201980081463.6, and name “Dual-chamber syringe with double-lumen intravenous injection set”. Technical Field

[0002] The present invention relates to a medical device, in particular to a multi-cavity intravenous injection set. Background Art

[0003] Delivering medical fluids to fluid-restricted patients typically involves administering the medical fluid intravenously through an intravenous (IV) set at a low flow rate from a fluid source. Traditional approaches often involve disconnecting the line used to deliver the IV push, which can be time-consuming at such low flow rates. Other conventional approaches may involve administering a priming solution to the fluid-restricted patient via a pump before delivering the medical fluid, which can delay the timely administration of the medical fluid to the fluid-restricted patient. Summary of the Invention

[0004] The disclosed subject matter relates to syringes. In certain embodiments, a dual-chamber syringe includes: an end wall; a main plunger including a main stopper, the main stopper and the end wall forming a main chamber; an auxiliary plunger mechanically associated with the main plunger, the auxiliary plunger including an auxiliary stopper, the auxiliary stopper and the main stopper forming an auxiliary chamber; a main nozzle extending from the end wall, the main nozzle in fluid communication with the main chamber; and an auxiliary nozzle extending from the end wall, the auxiliary nozzle in fluid communication with the auxiliary chamber.

[0005] In certain embodiments, a multi-lumen intravenous infusion set includes: an adapter comprising a main conduit and an auxiliary conduit; a valve housing comprising a housing port and a housing passage; a main lumen in fluid communication with the main conduit and the housing port; an auxiliary lumen in fluid communication with the auxiliary conduit and the housing port; and a valve disposed in the valve housing, the valve including a burst pressure, wherein the valve is configured to prevent fluid from flowing from the housing port to the housing passage when a pressure on the valve is less than the burst pressure, and wherein the valve is configured to allow fluid to flow from the housing port to the housing passage when a pressure on the valve is greater than the burst pressure.

[0006] In certain embodiments, a fluid delivery system includes: a dual-chamber syringe including an end wall; a main plunger including a main stopper, the main stopper and the end wall forming a main chamber; an auxiliary plunger in mechanical association with the main plunger, the auxiliary plunger including an auxiliary stopper, the auxiliary stopper and the main stopper forming an auxiliary chamber; a main nozzle extending from the end wall, the main nozzle in fluid communication with the main chamber; an auxiliary nozzle extending from the end wall, the auxiliary nozzle in fluid communication with the auxiliary chamber; and a multi-lumen intravenous set including an adapter including a main port and an auxiliary port, the main port being fluidically coupled to the main nozzle, and the auxiliary port a valve body configured to prevent fluid from flowing from the housing port to the housing passage when pressure across the valve is less than the bursting pressure, and a valve body configured to allow fluid to flow from the housing port to the housing passage when pressure across the valve is greater than the bursting pressure. BRIEF DESCRIPTION OF THE DRAWINGS

[0007] The accompanying drawings, which are included to provide a further understanding of the technology and are incorporated in and constitute a part of this specification, illustrate various aspects of the technology and together with the description serve to explain the principles of the technology.

[0008] Figure 1 A side view of a dual chamber syringe is shown with some portions cut away and broken away to show details, according to aspects of the present disclosure.

[0009] Figure 2 According to some aspects of the present disclosure, Figure 1 A perspective view of a dual chamber syringe is shown.

[0010] Figure 3 According to some aspects of the present disclosure, Figure 1 A cross-sectional perspective view of a dual-chamber syringe taken along line 3-3 shows the end wall of the syringe.

[0011] Figure 4 According to some aspects of the present disclosure, Figure 1 Detailed cross-sectional view of the main plunger of a dual chamber syringe is shown.

[0012] Figure 5 According to some aspects of the present disclosure, Figure 1Detailed cutaway perspective view of a dual chamber syringe with the activation member in an inactivated state.

[0013] Figure 6 According to some aspects of the present disclosure, Figure 5 Detailed plan view of the snap lock of the main plunger shown.

[0014] Figure 7 According to some aspects of the present disclosure, an active Figure 5 A detailed perspective view of the activation member is shown.

[0015] Figure 8 A plan view of a double lumen intravenous (IV) set is shown according to aspects of the present disclosure.

[0016] Figure 9 According to some aspects of the present disclosure, Figure 8 A plan view of a double-lumen intravenous injection set, with some parts cut away and shown in dotted lines to depict the internal details of the double-lumen intravenous injection set.

[0017] Figure 10 According to some aspects of the present disclosure, Figure 9 Detailed perspective view of the double lumen tubing adapter of the double lumen intravenous injection set.

[0018] Figure 11 A perspective view of a dual chamber syringe adapter is shown according to aspects of the present disclosure.

[0019] Figure 12 According to some aspects of the present disclosure, Figure 11 A sectional plan view taken along line 12-12.

[0020] Figure 13 A perspective view of a flush syringe adapter is shown according to aspects of the present disclosure.

[0021] Figure 14 According to some aspects of the present disclosure, Figure 13 A sectional plan view taken along line 14-14.

[0022] Figure 15 A plan view of a dual lumen intravenous injection set for use with a flush syringe in a pre-filled state is shown, with portions cut away and broken away to illustrate internal fluid pathways, according to aspects of the present disclosure.

[0023] Figure 16 According to some aspects of the present disclosure, Figure 15A plan view of a dual lumen intravenous injection set for use with the flush syringe shown, with portions cut away and broken away to illustrate internal fluid pathways.

[0024] Figure 17 According to some aspects of the present disclosure, a device for use with a vial and in a pre-filled state is shown. Figure 1 A plan view of a dual chamber syringe is shown with portions cut away and broken away to illustrate internal fluid pathways.

[0025] Figure 18 According to some aspects of the present disclosure, a post-fill state is shown. Figure 17 A plan view of a dual chamber syringe is shown with the vial and dual chamber syringe adapter removed from the dual chamber syringe with portions cut away and broken away to illustrate internal fluid pathways.

[0026] Figure 19 A plan view of a fluid delivery system in a pre-filled drug state is shown according to some aspects of the present disclosure. Figure 8 Used with the double-lumen intravenous injection set Figure 1 A dual chamber syringe with some portions cut away and broken away to show the internal fluid pathways.

[0027] Figure 20 According to some aspects of the present disclosure, a post-drug infusion state is shown. Figure 19 A plan view of a fluid delivery system showing a double lumen intravenous infusion set infused with medication, with portions cut away and broken away to show internal fluid pathways.

[0028] Figure 21 According to some aspects of the present disclosure, a device in a pre-flush state is shown. Figure 19 A plan view of a fluid delivery system with portions cut away and broken away to illustrate internal fluid pathways.

[0029] Figure 22 According to some aspects of the present disclosure, a post-flush state is shown. Figure 19 A plan view of a fluid delivery system with some portions cut away and broken away to illustrate internal fluid pathways.

[0030] Figure 23-26 Shown from Figure 21 The pre-flush state shown transitions to Figure 22 Detailed view of the dual chamber syringe shown in the post-flush state. DETAILED DESCRIPTION

[0031] In the following detailed description, specific details are set forth to provide an understanding of the present technology. However, it will be apparent to one of ordinary skill in the art that the present technology can be practiced without these specific details. In other cases, well-known structures and techniques have not been shown in detail in order to avoid obscuring the present technology.

[0032] Phrases such as "aspect" do not imply that such aspect is essential to the present technology or that such aspect applies to all configurations of the present technology. Disclosure related to an aspect may apply to all configurations, or to one or more configurations. An aspect may provide one or more examples of the present disclosure. Phrases such as "an aspect" may refer to one or more aspects, and vice versa. Phrases such as "an embodiment" do not imply that such embodiment is essential to the present technology or that such embodiment applies to all configurations of the present technology. Disclosure related to an embodiment may apply to all embodiments, or to one or more embodiments. An embodiment may provide one or more examples of the present disclosure. Phrases such as "an embodiment" may refer to one or more embodiments, and vice versa. Phrases such as "configuration" do not imply that such configuration is essential to the present technology or that such configuration applies to all configurations of the present technology. Disclosure related to a configuration may apply to all configurations, or to one or more configurations. A configuration may provide one or more examples of the present disclosure. Phrases such as "configuration" may refer to one or more configurations, and vice versa.

[0033] Figure 1-25 A fluid delivery system is shown, comprising a dual-chamber syringe compatible with a syringe pump that can be coupled to a dual-lumen intravenous (IV) set. The fluid delivery system is configured to remove a pre-filling solution from the dual-lumen IV set to be stored in the dual-chamber syringe, deliver medication at a predetermined flow rate, and administer any remaining medication remaining in the dual-lumen IV set by refilling the pre-filling solution stored in the dual-chamber syringe into the dual-lumen IV set.

[0034] Figure 1-6 A fluid delivery system 100 (eg, Figure 19 1 and 1 . In some embodiments, the dual chamber syringe 110 includes a cylindrical syringe barrel 112, an end wall 114, and a syringe collar 116. The end wall 114 is disposed at a first end 118 of the syringe barrel 112, and the syringe collar 116 is disposed at a second end 120 of the syringe barrel 112 opposite the first end 118. The syringe collar 116 extends radially outward from the syringe barrel 112 near the second end 120. The syringe barrel 112 includes a cylindrical inner chamber 122 extending between the end wall 114 and the syringe collar 116.

[0035] Special References Figure 3 , grooved channel 124 is recessed in an inner surface 126 of end wall 114. Inner surface 126 faces and is disposed within inner chamber 122. Channel 124 includes a notched end 128, a passageway end 130, and a recess 132 disposed between notched end 128 and passageway end 130. In some aspects, channel 124 includes opposing chamfered walls 134 extending between notched end 128 and recess 132, and between recess 132 and passageway end 130. Notched end 128 is in fluid communication with a recess 136 disposed in syringe barrel 112 at the intersection of syringe barrel 112 and end wall 114, proximate first end 118. Recess 136 extends axially inward from end wall 114 within inner chamber 122. Passageway end 130 is in fluid communication with a passageway 138 disposed through end wall 114. In some aspects, the channel 124 extends along a portion of the diameter of the inner face 126. The recess 136, the channel 124, and the passageway 138 collectively form an irrigation fluid flow path, the features and functions of which will be described in greater detail below.

[0036] The dual chamber syringe 110 also includes an inner tube 140. The inner tube 140 is disposed through the inner face 126 of the end wall 114 and the recess 132 and extends axially inwardly within the inner chamber 122. The inner tube 140 terminates within the inner chamber 122 and is axially offset inwardly relative to the syringe collar 116. In some aspects, the inner tube 140 extends approximately centrally through the inner face 126 of the end wall 114 and the recess 132 and is centrally disposed within the inner chamber 122.

[0037] The dual chamber syringe 110 also includes a primary nozzle 142 and a secondary nozzle 144. Both the primary nozzle 142 and the secondary nozzle 144 extend axially outward from the end wall 114 and are disposed externally relative to the inner chamber 122. In some aspects, the secondary nozzle 144 is centrally disposed on the end wall 114. The secondary nozzle 144 is coaxially aligned with the inner tube 140 and is in fluid communication with the inner tube 140. The primary nozzle 142 is radially offset from the secondary nozzle 144 on the end wall 114. The primary nozzle 142 is in fluid communication with a main chamber 145 of the inner chamber 122 via the passageway 138. A nozzle guide 143 also extends axially outward from the end wall 114 and surrounds the primary nozzle 142 and the secondary nozzle 144 to facilitate connection of the dual chamber syringe 110 to other medical components. In some aspects, the primary nozzle 142 and the secondary nozzle 144 are asymmetrical to prevent reverse or backward coupling of the dual chamber syringe 110 to the dual lumen intravenous injection set (800). In some aspects, the primary nozzle 142 and the secondary nozzle 144 are male Luer connectors. In other aspects, the primary nozzle 142 is a male Luer connector and the secondary nozzle 144 is a needleless connector. In other aspects, the primary nozzle 142 is a needleless connector and the secondary nozzle 144 is a male Luer connector.

[0038] Furthermore, the dual-chamber syringe 110 includes a main plunger 146 and an auxiliary plunger 148. The main plunger 146 and the auxiliary plunger 148 are in mechanical association such that both are received by the inner chamber 122 and are configured to slidably move within the inner chamber 122. The main plunger 146 includes a main stopper 150, a main head 152, and a stem 154 extending between the main stopper 150 and the main head 152. The main stopper 150 is disposed at a first stem end 156 of the stem 154, and the main head 152 is disposed at a second stem end 158 of the stem 154. The main plunger 146 is disposed within the inner chamber 122 such that a main chamber 159 is disposed between the main stopper 150 and the inner surface 126 of the end wall 114. The main plunger 146 includes a main receiving aperture 160 centrally disposed through the main stopper 150. The stem 154 extends from the main stopper 150 and includes a primary internal cavity 162 such that the primary internal cavity 162 is aligned with the primary receiving aperture 160. The primary receiving aperture 160 and the primary internal cavity 162 are configured to slidably receive the inner tube 140 of the dual chamber syringe 110. In some aspects, a first primary O-ring 164 is disposed in the primary receiving aperture 160 such that the inner tube 140 is slidably and sealingly received by the first primary O-ring 164 and is slidably received by the primary internal cavity 162. A chamber passage 166 is disposed through the stem 154 near the intersection of the stem 154 and the main stopper 150. In some aspects, a second primary O-ring 168 is disposed about the main stopper 150 for sealing engagement with the syringe barrel 112.

[0039] The main plunger 146 includes a locking member 170 disposed on the stem 154 between the main inner cavity 162 and the main head 152. Figure 6 , the locking member 170 includes opposing rod flanges 172. Each of the opposing rod flanges 172 includes a tapered tab 174 that projects radially outward and tapers axially toward the main head 152. The opposing rod flanges 172 are depressible radially inward toward each other. The locking member 170 is mechanically associated with components of the auxiliary plunger 148 to releasably lock the main plunger 146, as will be described in more detail below.

[0040] The auxiliary plunger 148 includes an auxiliary plug 176, an auxiliary head 178, and a body 180 extending between the auxiliary plug 176 and the auxiliary head 178. The auxiliary plug 176 is disposed at a first body end 182 of the body 180, and the auxiliary head 178 is disposed at a second body end 184 of the body 180. The body 180 includes a main section 186 and a neck section 188. In some aspects, the main section 186 of the body 180 includes a fin that includes a plus sign (e.g., +) cross-section. The main section 186 transitions to the neck section 188 at a tapered section 190. In some aspects, the neck section 188 includes a neck 192 disposed between the tapered section 190 and the auxiliary head 178. The neck 192 includes, in order from the tapered section 190 to the auxiliary head 178, a first counter-plunger slot 194, a second counter-plunger slot 196, a counter-activator locking slot 198, and a counter-activator resting slot 200. Furthermore, the auxiliary plunger 148 includes an auxiliary receiving aperture 201 centrally disposed through the auxiliary stopper 176 and a head aperture 202 centrally disposed through the auxiliary head 178. The auxiliary plunger 148 includes an auxiliary internal cavity 203 extending from the auxiliary stopper 176 at the auxiliary receiving aperture 201 to the auxiliary head 178 at the head aperture 202. The auxiliary receiving aperture 201 and the auxiliary internal cavity 203 are configured to slidably receive the rod 154 of the main plunger 146. In this configuration within the internal chamber 122, the auxiliary chamber 199 of the internal chamber 122 is disposed between the auxiliary stopper 176 and the main stopper 150. In some aspects, a first auxiliary O-ring 204 is disposed in the auxiliary receiving aperture 201 such that the rod 154 is slidably and sealingly received by the first auxiliary O-ring 204 and is slidably received by the auxiliary inner cavity 203. In some aspects, a second auxiliary O-ring 205 is disposed around the auxiliary stopper 176 for sealing engagement with the syringe barrel 112.

[0041] Opposing locking flanges 206 project outward from neck 192 and extend axially along neck 192. A projection 208 projects radially inward from each of the opposing locking flanges 206. The projections 208 align with the second opposing plunger slots 196. The opposing locking flanges 206 are configured to be pushed radially inward toward each other so that the projections 208 are received by the second opposing plunger slots 196. The opposing locking flanges 206 are deformable and configured to be pushed radially outward away from each other when engaged with the pin 209a. For example, the pin 209a includes a pull tab 209b formed on a clasp 209c, such that the clasp 209c is removably secured around the neck 192 and is disposed between the opposing locking flanges 206 and the neck 192 to urge the opposing locking flanges 206 radially outward. As the opposing locking flanges 206 are urged radially outward away from each other, the tabs 208 are held radially outward away from the second opposing plunger slots 196 .

[0042] The auxiliary plunger 148 includes a seat 210 that is centrally recessed in the auxiliary head 178 and coaxially aligned with the auxiliary inner cavity 203 and the head eyelet 202. The auxiliary plunger 148 also includes an activator 212. The activator 212 includes an activator body 214 and an activator head 216 located on the activator body 214. The activator body 214 is generally cylindrical and includes opposing activator flanges 218 formed in the activator body 214. Each of the opposing activator flanges 218 includes a tapered tab 220 that protrudes radially outward and tapers axially inward. The opposing activator flanges 218 are pressable radially inward toward each other. The activator body 214 is received by the head eyelet 202 such that, in the inactive state of the activator 212, the tapered tabs 220 of the opposing activator flange 218 are received by the opposing activator resting slot 200, and in the activated state of the activator 212, the tapered tabs 220 are received by and seated in the opposing activator locking slot 198 while the activator head 216 is received by the seat 210. Additionally, when the dual chamber syringe 110 is assembled, a resilient member 222 is disposed within the neck 192 between the main head 152 of the main plunger 146 and the activator head 216. The resilient member 222 is in an uncompressed state when the activator 212 is in the inactive state and in a compressed state when the activator 212 is in the activated state.

[0043] Reference Figure 8-10The fluid delivery system 100 also includes a dual-lumen intravenous (IV) set 800, which can be coupled to the dual-chamber syringe 110. Although the dual-lumen IV set 800 is shown with a dashed line to indicate a shortened length, it should be understood that the length of the dual-lumen IV set 800 can be any length, including, but not limited to, 1 meter, 2 meters, 3 meters, etc. The dual-lumen IV set 800 includes a connector 810, a valve housing 812, a valve 814, a main lumen 816, an auxiliary lumen 818, and an adapter 820. The connector 810 includes an outlet port 822 and a channel 824 fluidly connected to the outlet port 822. The connector 810 is configured to couple with a medical device, such as, for example, a catheter (shown). Although the fluid delivery system 100 is shown with one dual-lumen IV set 800, it is within the scope of the present application for the fluid delivery system 100 to include multiple dual-lumen IV sets to deliver multiple medications via multiple dual-chamber syringes in one IV set. The passage 824 is also fluidly connected to a housing passage 826 disposed in the valve housing 812. In some aspects, the passage 824 tapers from the housing passage 826 toward the outlet port 822. A housing port 828 is also disposed in the valve housing 812 and is in fluid communication with the housing passage 826. One end of each of the primary lumen 816 and the auxiliary lumen 818 is received by and in fluid communication with the housing port 828. The other end of the primary lumen 816 is in fluid communication with a primary conduit 830 disposed in the adapter 820, while the other end of the auxiliary lumen 818 is in fluid communication with an auxiliary conduit 832 disposed in the adapter 820, offset from the primary conduit 830.

[0044] The valve 814 is disposed in the valve housing 812 and is configured to seal the housing port 828 from the housing passage 826 until a predetermined bursting pressure is achieved from the housing port 828 overcoming the valve 814, at which point fluid is allowed to flow from the housing port 828 through the valve 814 and into the housing passage 826. In some aspects, the valve 814 is a one-way valve, such as, but not limited to, a check valve or an anti-siphon valve. The predetermined bursting pressure can be selected to burst at any predetermined pressure, such as, for example, 1 psi (pounds per square inch) or 0.5 psi.

[0045] The adapter 820 also includes a primary septum 834 and an auxiliary septum 836. The primary septum 834 is disposed in the primary conduit 830. The primary septum 834 is configured to seal a primary port 838 of the adapter 820 (which is disposed at one end of the primary conduit 830) to prevent fluid from flowing from the primary port 838 to the primary conduit 830 when the adapter 820 is disconnected from the medical device. However, when the adapter 820 is coupled to the dual-chamber syringe 110, the primary nozzle 142 engages the primary septum 834, allowing fluid from the primary nozzle 142 to flow through the primary port 838 to the primary lumen 816 via the primary conduit 830. The auxiliary septum 836 is disposed in the auxiliary conduit 832 and is configured to seal an auxiliary port 840 of the adapter 820 (which is disposed at one end of the auxiliary conduit 832) to prevent fluid from flowing from the auxiliary conduit 832 to the auxiliary port 840 when the adapter 820 is disconnected from the medical device. However, when the adapter 820 is coupled to the dual-chamber syringe 110, the auxiliary nozzle 144 engages the auxiliary septum 836, allowing fluid from the auxiliary conduit 832 to flow through the auxiliary port 840 to the auxiliary nozzle 144. Furthermore, an auxiliary valve 842 is disposed in the auxiliary conduit 832 to allow fluid to flow from the auxiliary lumen 818 to the auxiliary nozzle 144 via the auxiliary conduit 832, but to prevent fluid from flowing in the opposite direction from the auxiliary nozzle 144 to the auxiliary lumen 818. In some aspects, the auxiliary valve 842 is a one-way valve, such as, but not limited to, a duckbill valve or a check valve. Because the primary nozzle 142 and the auxiliary nozzle 144 are asymmetrical in some aspects, the primary nozzle 142 is configured to be received only by the primary port 838 and not by the auxiliary port 840, while the auxiliary nozzle 144 is configured to be received only by the auxiliary port 840 and not by the primary port 838, thereby preventing reverse or backward coupling of the dual-chamber syringe 110 to the dual-lumen intravenous set 800.

[0046] The adapter 820 also includes a raised ridge 844 disposed about the exterior and offset axially inward from the primary port 838 and the auxiliary port 840. The raised ridge 844 is configured to removably snap-fit ​​or interlock with a seat 846 disposed on the interior of the nozzle guide 143 when the dual-chamber syringe 110 and the dual-lumen intravenous injection set 800 are coupled together. In some aspects, a first plurality of serrations 848 are disposed on the exterior of the adapter 820 to facilitate gripping when handheld.

[0047] Reference Figure 11-12 The fluid delivery system 100 further includes a dual chamber syringe adapter 1100. The dual chamber syringe adapter 1100 can be coupled to the dual chamber syringe 110 and the vial adapter 1110 (e.g., Figure 17 ), which in turn is coupled to vial 1112 (also Figure 17(shown in FIG). Dual-chamber syringe adapter 1100 is configured to transfer fluid from vial 1112 to dual-chamber syringe 110. Dual-chamber syringe adapter 1100 includes a male connector 1114, a primary nozzle receiver 1116, an auxiliary nozzle receiver 1118, and a conduit 1120. In some aspects, a second plurality of serrations 1121 are provided on the exterior of dual-chamber syringe adapter 1100 to facilitate gripping when handheld. Conduit 1120 is provided through dual-chamber syringe adapter 1100 and fluidically couples male connector 1114 to primary nozzle receiver 1116. Nozzle seat 1122 is provided in auxiliary nozzle receiver 1118 for sealing engagement with auxiliary nozzle 144 and preventing any fluid from flowing through auxiliary nozzle 144. Dual-chamber syringe adapter 1100 also includes a cap 1124 hingedly coupled to male connector 1114 for removably covering or closing male connector 1114. In some aspects, male connector 1114 is a male Luer connector. Male connector 1114 is configured to couple with the female connector of vial adapter 1110. Primary nozzle receiver 1116 is configured to matingly receive primary nozzle 142 of dual chamber syringe 110, and secondary nozzle receiver 1118 is configured to matingly receive secondary nozzle 144 of dual chamber syringe 110, while adapter ridge 1126 provided on the exterior of dual chamber syringe adapter 1100 removably snap-fits or interlocks with seat 846. When dual chamber syringe adapter 1100 is coupled to dual chamber syringe 110, fluid in vial 1112 can be drawn into primary chamber 159 through primary nozzle 142 via vial adapter 1110, male connector 1114, and conduit 1120.

[0048] Reference Figure 13 and 14 , the fluid delivery system 100 also includes a flushing syringe adapter 1300. The flushing syringe adapter 1300 can be connected to a flushing syringe 1310 (e.g., Figure 1513) and the adapter 820 of the dual lumen IV set 800. The flush syringe adapter 1300 is configured to transfer fluid from the flush syringe 1310 to prime the dual lumen IV set 800 with saline. The flush syringe adapter 1300 includes a primary adapter nozzle 1312, an auxiliary adapter nozzle 1314, a syringe guide 1316, a female connector 1318, a primary passageway 1320, and an auxiliary passageway 1322. In some aspects, a third plurality of serrations 1324 is provided on the exterior of the flush syringe adapter 1300 to facilitate hand-held gripping. The syringe guide 1316 surrounds the primary adapter nozzle 1312 and the auxiliary adapter nozzle 1314 to facilitate coupling the flush syringe adapter 1300 to the dual lumen IV set 800 such that the primary adapter nozzle 1312 is received by the primary port 838 of the adapter 820, while the auxiliary adapter nozzle 1314 is received by the auxiliary port 840. In some aspects, primary adapter nozzle 1312 and auxiliary adapter nozzle 1314 are asymmetrical, such that primary adapter nozzle 1312 is configured to be received only by primary port 838 and not by auxiliary port 840, while auxiliary adapter nozzle 1314 is configured to be received only by auxiliary port 840 and not by primary port 838, to prevent reverse or backward coupling of flush syringe adapter 1300 to dual lumen intravenous set 800. In some aspects, primary adapter nozzle 1312 and auxiliary adapter nozzle 1314 are male Luer connectors. In other aspects, primary adapter nozzle 1312 is a male Luer connector and auxiliary adapter nozzle 1314 is a needleless connector. In still other aspects, primary adapter nozzle 1312 is a needleless connector and auxiliary adapter nozzle 1314 is a male Luer connector.

[0049] Primary passageway 1320 is disposed between primary adapter nozzle 1312 and adapter port 1328 disposed at female connector 1318, fluidically coupling them. In some aspects, female connector 1318 is a female Luer connector. Female connector 1318 is configured to couple with the male connector of flush syringe 1310. In some aspects, the male connector of flush syringe 1310 is a male Luer connector. Auxiliary passageway 1322 is disposed between auxiliary adapter nozzle 1314 and vent 1330, fluidically coupling them. A hydrophobic element 1332 is disposed in auxiliary passageway 1322 and is configured to allow air to escape from auxiliary adapter nozzle 1314 through vent 1330, but when hydrophobic element 1332 contacts liquid fluid (e.g., saline from flush syringe 1310), it prevents the liquid fluid from exiting vent 1330.

[0050] Figure 15 The dual lumen IV set 800 is shown for use with a flush syringe 1310 in a pre-filled state, and Figure 16The dual-lumen IV set 800 is shown in use with a flush syringe 1310 in a post-prime state. To prime the dual-lumen IV set 800 (which can be performed at the patient's bedside), the flush syringe adapter 1300 is coupled to the dual-lumen IV set 800 such that the primary adapter nozzle 1312 and the auxiliary adapter nozzle 1314 are received by the primary port 838 and the auxiliary port 840, respectively, and the adapter seat 1326 removably snap-fits with the ridge 844 of the adapter 820. With the flush syringe adapter 1300 coupled to the dual-lumen IV set 800, the dual-chamber syringe adapter 1100, pre-filled with saline, is coupled to the flush syringe adapter 1300 via the female connector 1318. The flush syringe 1310 delivers saline through the adapter port 1328 and the primary passage 1320 into the primary port 838 and the primary conduit 830. Saline flows from the main conduit 830 through the main lumen 816 until it reaches the housing port 828 and valve 814. The pressure on valve 814 is less than the predetermined burst pressure, so the saline travels through the auxiliary lumen 818 and auxiliary valve 842. During this flow process, air in the dual lumen IV set 800 has been forced through the hydrophobic element 1332 and out of the vent 1330, but once the saline contacts the hydrophobic element 1332, it prevents further saline flow. Because the saline is prevented from flowing through the hydrophobic element 1332, the remainder of the dual lumen IV set 800 is primed with saline. After the dual lumen IV set 800 is fully primed, it can then be connected to a medical device, such as a catheter. With the dual lumen intravenous injection set 800 coupled to the catheter, because the hydrophobic element 1332 prevents saline from flowing, the remaining saline in the flush syringe 1310 is flushed by generating pressure on the valve 814 that is higher than the predetermined burst pressure, causing the valve 814 to allow saline to flow through the housing passage 826 and out of the outlet port 822 to the catheter. The flush syringe adapter 1300, along with the flush syringe 1310, is then separated from the dual lumen intravenous injection set 800.

[0051] Figure 17 The dual chamber syringe 110 is shown in a pre-filled state and in use with the vial 12, and Figure 18The dual chamber syringe 110 is shown in a post-filled state, with the vial 1112 and the dual chamber syringe adapter 1100 separated from the dual chamber syringe 110. The pin 209a is inserted around the neck 192, pushing the opposing locking flange 206 radially outward, so that the tab 208 is held radially outward away from the second opposing plunger slot 196. With the tab 208 configured in this manner, the tapered tab 174 of the locking member 170 is removably received in the second opposing plunger slot 196, thereby locking the main plunger 146 to the auxiliary plunger 148. When the activator 212 is in the inactive state, the tapered tab 220 of the opposing activator flange 218 is received and seated in the opposing activator resting slot 200, so that the resilient member 222 is in its uncompressed state between the main head 152 of the main plunger 146 and the activator head 216. This configuration locks the main plunger 146 to the auxiliary plunger 148 so that the main stopper 150 is offset from the auxiliary stopper 176 by a predetermined distance, which can be preselected based on the specific desired prefill volume of the auxiliary chamber 199. The dual chamber syringe 110 is prefilled with saline in the auxiliary chamber 199, as shown in FIG. Figure 17 shown.

[0052] In use, such as in a pharmacy environment, the activator 212 of the dual chamber syringe 110 is actuated by axially inwardly compressing the activator head 216, causing the tapered tabs 220 of the opposing activator flanges 218 to be pressed radially toward each other, moved away from the opposing activator resting slots 200, and received in a locking manner by the opposing activator locking slots 198, while the activator head 216 is received by the seat 210. In this configuration, the resilient member 222 is in its compressed state between the main head 152 of the main plunger 146 and the activator head 216 positioned at the seat 210. Allowing the resilient member 222 to be in an uncompressed state prior to use can extend the shelf life of the dual chamber syringe 110. After activation of the activator 212, the dual chamber syringe 110 is coupled to the dual chamber syringe adapter 1100 such that the nozzle guide 143 facilitates mating insertion of the primary nozzle 142 into the primary nozzle receiver 1116 and the secondary nozzle 144 into the secondary nozzle receiver 1118, with the adapter ridge 1126 removably snap-fitting or interlocking with the seat 846. Because the secondary nozzle 144 is received by the secondary nozzle receiver 1118 and seats against the nozzle seat 1122, saline is prevented from accidentally flowing out of the secondary chamber 199 during transfer of fluid from the vial 1112 to the dual chamber syringe 110.

[0053] With the dual chamber syringe adapter 1100 coupled to the dual chamber syringe 110, the male connector 1114 is coupled to the vial adapter 1110, which is coupled to the vial 1112. When the primary plunger 146 is locked to the secondary plunger 148, pulling the secondary head 178 axially away from the syringe collar 116 draws the fluid (e.g., medication) from the vial 1112 through the dual chamber syringe adapter 1100 and primary nozzle 142 and into the primary chamber 159 via the passageway 138 without disturbing the saline in the secondary chamber 199, the internal tubing 140, and the primary inner lumen 162. Once the desired amount of medication has been drawn into the primary chamber 159, the dual chamber syringe adapter 1100 can be detached from the dual chamber syringe 110, as shown. Figure 18 shown.

[0054] Figure 19 The dual chamber syringe 110 of the fluid delivery system 100 is shown in a pre-filled state and in use with a dual lumen IV set 800. The dual lumen IV set 800 is filled with saline and fluidically coupled to a catheter 1910. The dual lumen IV set 800 is also fluidically coupled to the dual chamber syringe 110, which is mechanically engaged with a syringe pump 1920. While the syringe pump 1920 securely supports the syringe barrel 112, the syringe pump 1920 also mechanically engages the auxiliary head 178 to selectively control the axial movement of the auxiliary plunger 148.

[0055] The dual chamber syringe 110 and the dual lumen intravenous injection set 800 transition from the pre-infusion state to the post-infusion state. Figure 20114 . This transition involves removing the pin 209a from the neck 192, causing the opposing locking flanges 206 to be radially urged toward each other and the tabs 208 to engage the tapered tabs 174 of the locking member 170, releasing the tapered tabs 174 from the second opposing plunger slots 196. With the auxiliary head 178 held in place by the syringe pump 1920, the release or unseating of the tapered tabs 174 from the second opposing plunger slots 196 allows the resilient member 222 to press against the main head 152 in a compressed state, which in turn pushes the main plunger 146 axially toward the end wall 114. As the main plunger 146 is urged axially toward the end wall 114, the medicament in the main chamber 159 is forced through the passageway 138 and out of the primary nozzle 142 into the main conduit 830 to the main lumen 816. At the same time, and because the pressure on the valve 814 is less than the predetermined burst pressure, the medication displaces the saline in the dual lumen IV set 800, traveling out of the auxiliary port 840 and through the auxiliary nozzle 144 to fill the auxiliary chamber 199 via the inner tube 140, the main inner lumen 162, and the chamber passage 166. The main plunger 146 continues to fill the dual lumen IV set 800 with medication until the tapered tab 174 is received by and seats against the first opposing plunger slot 194, which prevents the resilient member 222 from further pushing the main plunger 146.

[0056] The dual-chamber syringe 110 and the dual-lumen intravenous injection set 800 transition from the post-infusion drug state to the pre-flushing state, such as Figure 21 As shown in FIG. 1 , the transition involves the syringe pump 1920 axially moving the auxiliary head 178 of the auxiliary plunger 148 toward the end wall 114 to deliver the remaining medication in the primary chamber 159 to the primary conduit 830 and the primary lumen 816 via the passageway 138 and the primary nozzle 142. Because the auxiliary valve 842 prevents saline from flowing from the auxiliary chamber 199 to the auxiliary lumen 818, as the auxiliary plunger 148 moves axially, pressure builds on the valve 814 and exceeds a predetermined burst pressure, causing the axial movement of the auxiliary plunger 148 to force the medication past the valve 814 and into the housing passageway 826, through the channel 824 and the outlet port 822, to the conduit 1910. As the auxiliary plunger 148 moves axially toward the end wall 114, the tapered tab 174 unseats from the first opposing plunger slot 194 and moves toward the second opposing plunger slot 196.

[0057] Once the main stopper 150 abuts the inner surface 126 of the end wall 114, the dual chamber syringe 110 and the dual lumen intravenous injection set 800 transition from the pre-flush state to the post-flush state. Figure 22 This transition is shown in Figure 23-26 Shown in. Figure 23The pre-flush state is shown, wherein the primary stopper 150 abuts the inner face 126 of the end wall 114, and medication remains in the passage 124 and the recess 136. The second primary O-ring 168 seals the recess 136 and prevents the medication from flowing into the auxiliary chamber 199. During this transition, as the auxiliary plunger 148 continues to move axially toward the end wall 114, the pressure on the second primary O-ring 168 increases, forcing saline in the auxiliary chamber 199 past the second primary O-ring 168 and through the recess 136 into the passage 124, forcing the medication through the passage 138 to the primary nozzle 142. The syringe pump 1920 continues to move the auxiliary plunger 148 axially, forcing saline from the auxiliary chamber 199 to flush the medication from the passage 124. In this manner, the saline forces the medication through the primary lumen 816, allowing all of the medication to be delivered to the patient and the dual lumen IV set 800 to be primed with saline.

[0058] In some aspects, the dual-chamber syringe is preloaded with saline in the auxiliary chamber 199. In some aspects, the auxiliary chamber 199 is configured to receive the perfusion solution from the dual-lumen IV set 800, but is not used for a reserve flush. In some aspects, the auxiliary chamber 199 is configured to deactivate the auxiliary plunger 148 upon receiving the perfusion solution from the dual-lumen IV set 800, and is configured to indicate that the dual-chamber syringe 110 is ready for medication infusion. In some aspects, the fluid delivery system 100 includes a valve lock to prevent fluid from being delivered to the patient during perfusion. In some aspects, the perfusion volume can be selected in 0.1 mL increments. In some aspects, the auxiliary plunger 148 includes a plunger handle base that rotates to allow the plunger rod to rotate and disengage while maintaining friction with the syringe pump paddle. In some aspects, the auxiliary plunger 148 is automatically released at a certain plunger depth, rather than being released by the pin 209a, so that the infusion is not interrupted and manual intervention is not required. In some aspects, the fluid delivery system 100 includes a vent to vent trapped air bubbles via an air permeable filter. In some aspects, the fluid delivery system 100 is configured to pre-set and limit the priming volume via a pin that limits the plunger's travel.

[0059] Description of the terms of this technology

[0060] For convenience, various examples of some aspects of the present disclosure are described as numbered clauses (1, 2, 3, etc.). They are provided as examples and do not limit the present technology. The reference numerals and the identification of the figures are provided below only as examples and for illustrative purposes, and the clauses are not limited by those identifications.

[0061] Item 1. A dual-chamber syringe comprising: an end wall; a main plunger comprising a main stopper, the main stopper forming a main chamber with the end wall; an auxiliary plunger mechanically associated with the main plunger, the auxiliary plunger comprising an auxiliary stopper, the auxiliary stopper forming an auxiliary chamber with the main stopper; a main nozzle extending from the end wall, the main nozzle being in fluid communication with the main chamber; and an auxiliary nozzle extending from the end wall, the auxiliary nozzle being in fluid communication with the auxiliary chamber.

[0062] Clause 2. The dual chamber syringe of clause 1, wherein the secondary nozzle extends centrally from the end wall.

[0063] Clause 3. The dual chamber syringe of clause 2, wherein the primary nozzle is radially offset from the secondary nozzle.

[0064] Clause 4. A dual chamber syringe according to any preceding clause, wherein the primary nozzle and the secondary nozzle are asymmetric.

[0065] Clause 5. The dual chamber syringe of any preceding clause, further comprising: a nozzle guide extending from the end wall and surrounding the primary nozzle and the secondary nozzle.

[0066] Clause 6. A dual chamber syringe according to any preceding clause, wherein the primary plunger is lockable to the secondary plunger.

[0067] Clause 7. A dual chamber syringe according to any preceding clause, wherein the end wall comprises a channel.

[0068] Clause 8. The dual chamber syringe of clause 7, wherein the auxiliary chamber is in fluid communication with the primary nozzle via the passage when the dual chamber syringe transitions from a pre-flush state to a post-flush state.

[0069] Clause 9. A dual chamber syringe according to any preceding clause, wherein the auxiliary nozzle is in fluid communication with the auxiliary chamber via an internal tube extending from the end wall.

[0070] Clause 10. The dual chamber syringe of clause 9, wherein the inner tube is received by the main inner cavity of the main plunger.

[0071] Item 11. A multi-lumen intravenous injection set comprising: an adapter comprising a main conduit and an auxiliary conduit; a valve housing comprising a housing port and a housing passage; a main lumen in fluid communication with the main conduit and the housing port; an auxiliary lumen in fluid communication with the auxiliary conduit and the housing port; and a valve disposed in the valve housing, the valve comprising a burst pressure, wherein the valve is configured to prevent fluid from flowing from the housing port to the housing passage when a pressure on the valve is less than the burst pressure, and wherein the valve is configured to allow fluid to flow from the housing port to the housing passage when a pressure on the valve is greater than the burst pressure.

[0072] Clause 12. The multi-lumen intravenous infusion set according to clause 11, wherein the main lumen is in fluid communication with the auxiliary lumen when the pressure on the valve is less than the burst pressure.

[0073] Item 13. The multi-lumen intravenous injection set according to Item 11 or 12, further comprising: a main diaphragm disposed in the main conduit and an auxiliary diaphragm disposed in the auxiliary conduit.

[0074] Item 14. A multi-lumen intravenous injection set according to Item 13, wherein the main diaphragm is configured to seal a main port provided at the main conduit to prevent fluid from flowing from the main port to the main conduit when separated from the medical device, and is configured to allow fluid to flow from the main port to the main conduit when engaged with the medical device, and wherein the auxiliary diaphragm is configured to seal an auxiliary port provided at the auxiliary conduit to prevent fluid from flowing from the auxiliary port to the auxiliary conduit when separated from the medical device, and is configured to allow fluid to flow from the auxiliary port to the auxiliary conduit when engaged with the medical device.

[0075] Item 15. The multi-lumen intravenous injection set according to Item 14 further includes: an auxiliary valve arranged in the auxiliary pipeline, the auxiliary valve being configured to allow fluid to flow from the auxiliary lumen to the auxiliary port and to prevent fluid from flowing from the auxiliary port to the auxiliary lumen.

[0076] Clause 16. The multi-lumen intravenous infusion set according to clause 15, wherein the auxiliary valve is a check valve.

[0077] Clause 17. The multi-lumen intravenous infusion set according to clauses 14-16, wherein the primary port and the auxiliary port are asymmetric.

[0078] Item 18. A fluid delivery system comprising: a dual chamber syringe comprising an end wall; a main plunger comprising a main stopper, the main stopper forming a main chamber with the end wall; an auxiliary plunger mechanically associated with the main plunger, the auxiliary plunger comprising an auxiliary stopper, the auxiliary stopper forming an auxiliary chamber with the main stopper; a main nozzle extending from the end wall, the main nozzle being in fluid communication with the main chamber; an auxiliary nozzle extending from the end wall, the auxiliary nozzle being in fluid communication with the auxiliary chamber; and a multi-lumen intravenous injection set comprising an adapter comprising a main port and an auxiliary port, the main port being fluidically coupled to the main nozzle, and the auxiliary port being fluidically coupled to the auxiliary chamber. a valve body configured to prevent fluid from flowing from the housing port to the housing passage when a pressure across the valve is less than the bursting pressure, and wherein the valve body is configured to allow fluid to flow from the housing port to the housing passage when a pressure across the valve is greater than the bursting pressure.

[0079] Clause 19. The fluid delivery system of clause 18, wherein the main plunger includes a locking member configured to removably lock the main plunger to the auxiliary plunger.

[0080] Clause 20. The fluid delivery system according to clause 18 or 19, further comprising an auxiliary valve disposed in the auxiliary conduit, the auxiliary valve being configured to allow fluid to flow from the auxiliary lumen to the auxiliary port and to prevent fluid from flowing from the auxiliary port to the auxiliary lumen.

[0081] The foregoing description is provided to enable those skilled in the art to implement the various configurations described herein. Although the present technology has been described in detail with reference to various drawings and configurations, it should be understood that these are only for illustrative purposes and should not be understood as limiting the scope of the present technology.

[0082] Many other methods may exist to implement the present technology. The various functions and elements described herein may be divided into functions and elements different from those shown without departing from the scope of the present technology. Various modifications to these structures will be apparent to those skilled in the art, and the general principles defined herein may be applied to other structures. Therefore, those of ordinary skill in the art may make many changes and modifications to the present technology without departing from the scope of the present technology.

[0083] As used herein, the phrase "at least one of" following a list of items (with the terms "and" or "or" separating any of the items) modifies the list as a whole, rather than each member (i.e., each item) of the list. The phrase "at least one of" does not require selection of at least one of each item listed; rather, the phrase allows for a meaning that includes at least one of any of the items, and / or at least one of any combination of the items, and / or at least one of each of the items. For example, the phrase "at least one of A, B, and C" or "at least one of A, B, or C" each refer to: only A, only B, or only C; any combination of A, B, C; and / or at least one of A, B, and C.

[0084] Furthermore, to the extent that the terms "including," "having," or similar terms are used in the specification or claims, such terms are intended to be inclusive, in a manner similar to the term "comprising," as interpreted when "comprising" is employed as a transitional term in a claim. The word "exemplary" is used herein to mean "serving as an example, instance, or illustration." Any embodiment described herein as "exemplary" is not necessarily to be construed as preferred or advantageous over other embodiments.

[0085] Reference to an element in the singular is not intended to mean "one and only one" unless specifically stated otherwise, but rather "one or more." The term "some" refers to one or more. All structural and functional equivalents of the various elements of the configurations described throughout this disclosure that are known or later become known to those of ordinary skill in the art are expressly incorporated herein by reference and are intended to be encompassed by the present technology. In addition, nothing disclosed herein is intended to be dedicated to the public, regardless of whether such disclosure is explicitly stated in the above description.

[0086] Although certain aspects and embodiments of the present technology have been described, they are given by way of example only and are not intended to limit the scope of the present technology. In fact, the novel methods and systems described herein may be embodied in a variety of other forms without departing from the spirit thereof. The accompanying claims and their equivalents are intended to cover any form or modification that falls within the scope and spirit of the present technology.

Claims

1. A multi-cavity intravenous injection set, comprising: an adapter comprising a primary conduit and an auxiliary conduit; a valve housing including a housing port and a housing passage; a main lumen in fluid communication with the main conduit and the housing port; an auxiliary lumen in fluid communication with the auxiliary conduit and the housing port; and A valve is disposed in the valve housing, the valve including a burst pressure, wherein the valve is configured to prevent fluid from flowing from the housing port to the housing passage when pressure across the valve is less than the burst pressure, and wherein the valve is configured to allow fluid to flow from the housing port to the housing passage when pressure across the valve is greater than the burst pressure.

2. The multi-cavity intravenous injection set according to claim 1, wherein: When the pressure on the valve is less than the burst pressure, the primary lumen is in fluid communication with the secondary lumen.

3. The multi-lumen intravenous injection set according to claim 1, further comprising: A main diaphragm is provided in the main pipe and an auxiliary diaphragm is provided in the auxiliary pipe.

4. The multi-cavity venous injection set according to claim 3, wherein: The main diaphragm is configured to seal a main port provided at the main conduit to prevent fluid from flowing from the main port to the main conduit when separated from the medical device, and is configured to allow fluid to flow from the main port to the main conduit when engaged with the medical device, and wherein the auxiliary diaphragm is configured to seal an auxiliary port provided at the auxiliary conduit to prevent fluid from flowing from the auxiliary port to the auxiliary conduit when separated from the medical device, and is configured to allow fluid to flow from the auxiliary port to the auxiliary conduit when engaged with the medical device.

5. The multi-lumen intravenous injection set according to claim 4, further comprising: An auxiliary valve is disposed in the auxiliary conduit, the auxiliary valve being configured to allow fluid to flow from the auxiliary lumen to the auxiliary port and to prevent fluid from flowing from the auxiliary port to the auxiliary lumen.

6. The multi-cavity intravenous injection set according to claim 5, wherein: The auxiliary valve is a check valve.

7. The multi-lumen venous injection set according to claim 4, wherein: The primary port and the secondary port are asymmetric.

8. A fluid delivery system comprising: A dual-chamber syringe comprising end wall; a main plunger comprising a main stopper, said main stopper forming a main chamber with said end wall; an auxiliary plunger in mechanical association with the main plunger, the auxiliary plunger comprising an auxiliary plug, the auxiliary plug forming an auxiliary chamber with the main plug; a primary nozzle extending from the end wall, the primary nozzle being in fluid communication with the primary chamber; an auxiliary nozzle extending from the end wall, the auxiliary nozzle being in fluid communication with the auxiliary chamber; and Multi-cavity intravenous injection set, which includes an adapter comprising a primary port and an auxiliary port, the primary port fluidly coupled to the primary nozzle and the auxiliary port fluidly coupled to the auxiliary nozzle; a valve housing including a housing port and a housing passage; a main lumen in fluid communication with a main conduit disposed in the adapter and in fluid communication with the housing port; an auxiliary lumen in fluid communication with auxiliary tubing disposed in the adapter and in fluid communication with the housing port; and A valve is disposed in the valve housing, the valve including a burst pressure, wherein the valve is configured to prevent fluid from flowing from the housing port to the housing passage when pressure across the valve is less than the burst pressure, and wherein the valve is configured to allow fluid to flow from the housing port to the housing passage when pressure across the valve is greater than the burst pressure.

9. The fluid delivery system according to claim 8, wherein: The main plunger includes a locking member configured to removably lock the main plunger to the auxiliary plunger.

10. The fluid delivery system of claim 8, further comprising an auxiliary valve disposed in the auxiliary conduit, the auxiliary valve configured to allow fluid to flow from the auxiliary lumen to the auxiliary port and to prevent fluid from flowing from the auxiliary port to the auxiliary lumen.

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